Dr Michael Lovelace

Dr Michael Lovelace

Conjoint Senior Lecturer

B. Sc (Hons). Deakin University 1999, PhD 2006

Medicine & Health
School of Clinical Medicine

Dr. Lovelace has over 15 years’ experience working in the interrelated fields of neuroscience, immunology and developmental neurobiology/stem cell biology, and currently works as a Senior Postdoctoral Research Scientist in the laboratory of clinical neurologist Prof. Bruce Brew (August 2015-present). He is also the manager of the St. Vincent's Centre for Applied Medical Research (AMR) Live Imaging Facility (LIF), a flow cytometry and microscope core facility. His previous positions have included working with esteemed neuroscientist Prof. Max Bennett OA, at Brain and Mind Research Institute, University of Sydney, and Opthalmologist and Developmental Neurobiologist Prof. Tailoi Chan-Ling in 2009-11 (an ongoing collaboration). He has 29 total published articles, preprints and conference abstracts (8 of those first author), which in total to date have garnered 899 citations (688 last 5 years); h-index = 14. An additional 15 publications are in revision or preparation for submission.

Positions - 2015 Aug – present: St. Vincent’s Centre for Applied Medical Research. 2015: Haematology Laboratory, Nepean Clinical School, USYD (2 x 3 month 0.5 FTE positions). 2012-2014: Research Officer, Vascular Lab, Centenary Institute, Sydney. 2009-October 2011: Postdoctoral Fellow, Retinal and Developmental Neurobiology Laboratory, Department of Anatomy and Histology, USYD, including previous Charles D. Kelman M.D. Postdoctoral Scholar (International Retinal Research Foundation, United States).

Phone
02 8382 4931
Location
St. Vincent's Centre for Applied Medical Research
  • Journal articles | 2024
    Malepathirana T; Senanayake D; Gautam V; Engel M; Balez R; Lovelace MD; Sundaram G; Heng B; Chow S; Marquis C; Guillemin GJ; Brew B; Jagadish C; Ooi L; Halgamuge S, 2024, 'Visualization of incrementally learned projection trajectories for longitudinal data', Scientific Reports, 14, http://dx.doi.org/10.1038/s41598-024-63511-z
    Journal articles | 2024
    Summers BS; Thomas Broome S; Pang TWR; Mundell HD; Koh Belic N; Tom NC; Ng ML; Yap M; Sen MK; Sedaghat S; Weible MW; Castorina A; Lim CK; Lovelace MD; Brew BJ, 2024, 'A Review of the Evidence for Tryptophan and the Kynurenine Pathway as a Regulator of Stem Cell Niches in Health and Disease', International Journal of Tryptophan Research, 17, http://dx.doi.org/10.1177/11786469241248287
    Journal articles | 2024
    Weible MW; Lovelace MD; Mundell HD; Pang TWR; Chan-Ling T, 2024, 'BMPRII+neural precursor cells isolated and characterized from organotypic neurospheres: an in vitro model of human fetal spinal cord development', Neural Regeneration Research, 19, pp. 447 - 457, http://dx.doi.org/10.4103/1673-5374.373669
    Journal articles | 2021
    Qin J; Lovelace MD; Mitchell AJ; de Koning-Ward T; Grau GER; Pai S, 2021, 'Perivascular macrophages create an intravascular niche for CD8+ T cell localisation prior to the onset of fatal experimental cerebral malaria', Clinical and Translational Immunology, 10, pp. e1273, http://dx.doi.org/10.1002/cti2.1273
    Journal articles | 2020
    Skarratt KK; Gu BJ; Lovelace MD; Milligan CJ; Stokes L; Glover R; Petrou S; Wiley JS; Fuller SJ, 2020, 'A P2RX7 single nucleotide polymorphism haplotype promotes exon 7 and 8 skipping and disrupts receptor function', FASEB Journal, 34, pp. 3884 - 3901, http://dx.doi.org/10.1096/fj.201901198RR
    Journal articles | 2019
    Cysique LA; Jugé L; Lennon MJ; Gates TM; Jones SP; Lovelace MD; Rae CD; Johnson TP; Nath A; Brew BJ, 2019, 'HIV brain latency as measured by CSF BcL11b relates to disrupted brain cellular energy in virally suppressed HIV infection', AIDS, 33, pp. 433 - 441, http://dx.doi.org/10.1097/QAD.0000000000002076
    Journal articles | 2019
    Leeson H; Chan-Ling T; Lovelace M; Brownlie J; Gu B; Weible M, 2019, 'P2X7 receptor signaling during adult hippocampal neurogenesis', Neural Regeneration Research, 14, pp. 1684 - 1694, http://dx.doi.org/10.4103/1673-5374.257510
    Journal articles | 2019
    Leeson HC; Chan-Ling T; Lovelace MD; Brownlie JD; Weible II MW; Gu BJ, 2019, 'Real-time Live-cell Flow Cytometry to Investigate Calcium Influx, Pore Formation, and Phagocytosis by P2X7 Receptors in Adult Neural Progenitor Cells', Journal of Visualized Experiments, http://dx.doi.org/10.3791/59313-v
    Journal articles | 2019
    Leeson HC; Chan-Ling T; Lovelace MD; Brownlie JD; Weible MW; Gu BJ, 2019, 'Real-time live-cell flow cytometry to investigate calcium influx, pore formation, and phagocytosis by P2X7 receptors in adult neural progenitor cells', Journal of Visualized Experiments, 2019, http://dx.doi.org/10.3791/59313
    Journal articles | 2018
    Leeson HC; Kasherman MA; Chan-Ling T; Lovelace MD; Brownlie JC; Toppinen KM; Gu BJ; Weible MW, 2018, 'P2X7 Receptors Regulate Phagocytosis and Proliferation in Adult Hippocampal and SVZ Neural Progenitor Cells: Implications for Inflammation in Neurogenesis', Stem Cells, 36, pp. 1764 - 1777, http://dx.doi.org/10.1002/stem.2894
    Journal articles | 2017
    Lennon MJ; Jones SP; Lovelace MD; Guillemin GJ; Brew BJ, 2017, 'Bcl11b-A critical neurodevelopmental transcription factor-roles in health and disease', Frontiers in Cellular Neuroscience, 11, pp. 89, http://dx.doi.org/10.3389/fncel.2017.00089
    Journal articles | 2017
    Lovelace MD; Powter EE; Coleman PR; Zhao Y; Parker A; Chang GH; Lay AJ; Hunter J; McGrath AP; Jormakka M; Bertolino P; McCaughan G; Kavallaris M; Vadas MA; Gamble JR, 2017, 'The RhoGAP protein ARHGAP18/SENEX localizes to microtubules and regulates their stability in endothelial cells', Molecular Biology of the Cell, 28, pp. 1066 - 1078, http://dx.doi.org/10.1091/mbc.E16-05-0285
    Journal articles | 2017
    Lovelace MD; Varney B; Sundaram G; Lennon MJ; Lim CK; Jacobs K; Guillemin GJ; Brew BJ, 2017, 'Recent evidence for an expanded role of the kynurenine pathway of tryptophan metabolism in neurological diseases', Neuropharmacology, 112, pp. 373 - 388, http://dx.doi.org/10.1016/j.neuropharm.2016.03.024
    Journal articles | 2016
    Lennon MJ; Jones SP; Lovelace MD; Guillemin GJ; Brew BJ, 2016, 'Bcl11b: A New Piece to the Complex Puzzle of Amyotrophic Lateral Sclerosis Neuropathogenesis?', Neurotoxicity Research, 29, pp. 201 - 207, http://dx.doi.org/10.1007/s12640-015-9573-5
    Journal articles | 2016
    Lovelace MD; Varney B; Sundaram G; Franco NF; Ng ML; Pai S; Lim CK; Guillemin GJ; Brew BJ, 2016, 'Current evidence for a role of the kynurenine pathway of tryptophan metabolism in multiple sclerosis', Frontiers in Immunology, 7, pp. 246, http://dx.doi.org/10.3389/fimmu.2016.00246
    Journal articles | 2015
    , 2015, 'P2X7 IS AN ARCHAIC SCAVENGER RECEPTOR RECOGNIZING APOPTOTIC NEUROBLASTS IN EARLY HUMAN NEUROGENESIS', Receptors & Clinical Investigation, http://dx.doi.org/10.14800/rci.699
    Journal articles | 2015
    Lovelace MD; Gu BJ; Eamegdool SS; Weible MW; Wiley JS; Allen DG; Chan-Ling T, 2015, 'P2X7 receptors mediate innate phagocytosis by human neural precursor cells and neuroblasts', Stem Cells, 33, pp. 526 - 541, http://dx.doi.org/10.1002/stem.1864
    Journal articles | 2013
    Lovelace MD; Yap ML; Yip J; Muller W; Wijburg O; Jackson DE, 2013, 'Absence of platelet endothelial cell adhesion molecule 1, PECAM-1/ CD31, in vivo increases resistance to salmonella enterica serovar typhimurium in mice', Infection and Immunity, 81, pp. 1952 - 1963, http://dx.doi.org/10.1128/IAI.01295-12
    Journal articles | 2012
    Werry EL; Liu GJ; Lovelace MD; Nagarajah R; Bennett MR, 2012, 'Glutamate potentiates lipopolysaccharide-stimulated interleukin-10 release from neonatal rat spinal cord astrocytes', Neuroscience, 207, pp. 12 - 24, http://dx.doi.org/10.1016/j.neuroscience.2012.01.039
    Journal articles | 2012
    Werry EL; Liu GJ; Lovelace MD; Nagarajah R; Hickie IB; Bennett MR, 2012, 'Corrigendum to "lipopolysaccharide-stimulated interleukin-10 release from neonatal spinal cord microglia is potentiated by glutamate". [Neuroscience 175 (2011) 93-103]', Neuroscience, 200, pp. 261, http://dx.doi.org/10.1016/j.neuroscience.2011.11.012
    Journal articles | 2011
    Werry EL; Liu GJ; Lovelace MD; Nagarajah R; Hickie IB; Bennett MR, 2011, 'Lipopolysaccharide-stimulated interleukin-10 release from neonatal spinal cord microglia is potentiated by glutamate', Neuroscience, 175, pp. 93 - 103, http://dx.doi.org/10.1016/j.neuroscience.2010.10.080
    Journal articles | 2007
    Lovelace MD; Cahill DM, 2007, 'A rapid cell counting method utilising acridine orange as a novel discriminating marker for both cultured astrocytes and microglia', Journal of Neuroscience Methods, 165, pp. 223 - 229, http://dx.doi.org/10.1016/j.jneumeth.2007.06.009
    Journal articles | 2003
    Lovelace M; Watson TG; Stephenson GL, 2003, 'Steroid 21-hydroxylase expression in cultured rat astrocytes', Brain Research Bulletin, 61, pp. 609 - 615, http://dx.doi.org/10.1016/j.brainresbull.2003.07.003
  • Conference Papers | 2022
    Lovelace MD; Sardesai V; Lim CK; Guillemin GJ; Brew BJ, 2022, 'Laquinimod as a novel regulator of Kynurenine Pathway in Neural Stem Cells and Monocytes', in MULTIPLE SCLEROSIS JOURNAL, SAGE PUBLICATIONS LTD, pp. 39 - 40, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000939493200088&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2022
    Lovelace MD; Sardesai V; Lim CK; Guillemin GJ; Brew BJ, 2022, 'Laquinimod as a novel regulator of Kynurenine Pathway in Neural Stem Cells and Monocytes', in MULTIPLE SCLEROSIS JOURNAL, SAGE PUBLICATIONS LTD, AUSTRALIA, Hobart, pp. 39 - 40, presented at MS Australia Progress in MS Research Scientific Conference, AUSTRALIA, Hobart, 04 April 2022 - 05 April 2022, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000899138300087&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Preprints | 2022
    Malepathirana T; Senanayake D; Gautam V; Engel M; Balez R; Lovelace MD; Sundaram G; Heng B; Chow S; Marquis C; Guillemin G; Brew B; Jagadish C; Ooi L; Halgamuge S, 2022, Visualization of Incrementally Learned Projection Trajectories for Longitudinal Data, http://dx.doi.org/10.1101/2022.11.25.515889

Dr. Lovelace has attracted a total of $1,229,808 in competitive grant funding -

  • $144,000 in grants for salary and research support (including 1 x $75,000 Perpetual IMPACT Grant);
  • $150,000 for Investigator Initiated Trial (IIT) completion;
  • $926,808 from 28 equipment grants in a variety of schemes (2 x NHMRC equipment grants, 3 x Rebecca Cooper Medical Research Foundation grants, multiple Bosch Institute small equipment grants, 7 x St. Vincent's AMR Equipment Grants, 2 x Ian Potter Foundation grants (2018 and 2020, $100,000 each) and one 2019 Perpetual IMPACT grant ($50,000, funded by Baxter Charitable Foundation);
  • $9,000 in travel grants for conference or collaborator short-stays.

 

 

Prizes and Awards

2019 Winner of Association for Research in Vision and Opthalmology (ARVO) Scientific Image Contest.

2017 Awarded 5th Prize, Bosch Institute Annual Scientific Meeting poster prize.

2016 – Top 20 Finalist, Bosch Institute Advanced Microscopy Facility Micrograph of the Year competition.

2016 Awarded 2nd prize in the Light Microscopy Australia (LMA) Micrograph Competition.

2015 – Shortlisted finalist for Stem Cells (Peer-Reviewed Scientific Journal) Young Investigator Award.

2014Winner of Rebecca L. Cooper Medal and Prize for best postdoctoral publication in a Bosch Institute Laboratory, University of Sydney.

2013 – Finalist in the Australasian Society for Stem Cell Research “Small Objects, Big Impact Image Competition. Image selected for exhibition at Questacon, and toured around Australia.

2013 Winner of the National Health & Medical Research Council (NHMRC) Science to Art Prize.

2013 – Awarded Joint 3rd Prize, Centenary Institute Scientific Image Award.

2013 – Top 10 Finalist and highly commended award, Australia Museum New Scientist Eureka Prize for Science Photography.

2012 – Top 20 Finalist (2 images) and 9th prize winner, Bosch Institute Advanced Microscopy Facility Micrograph of the Year competition.

2012 – Top 5 Finalist, Centenary Institute Scientific Image Award.

2011 – Highly commended award in the Bosch Institute Advanced Microscopy Facility Molecular Probes Image Prize.

2011 – Highly commended award in the National Health and Medical Research Council (NHMRC) Science to Art Prize.

2010 Awarded 2nd prize in the Bosch Institute Advanced Microscopy Facility Micrograph of the Year competition.

2010 Awarded 2nd prize in the Mater Medical Research Institute Stem Cell Symposium poster competition.

2010 Awarded the Charles D Kelman Postdoctoral Scholar Award (International Retinal Research Foundation, USA).

2009 Awarded the Dintenfass Memorial Plaque for the most interesting or innovative Rebecca Cooper Medical Research Foundation research grant proposal

Dr. Lovelace has current interests in understanding the impact of a dysregulated Kynurenine pathway and production of neurotoxic metabolites on regeneration and repair in Multiple Sclerosis, using mouse cell culture and disease models, and human iPS-derived cells.

My Research Supervision

Recently completed - one UNSW Med Honours student in 2022, one in 2023. One received a High Distinction, the other a Distinction (very close to HD cutoff).

Two students are awaiting approval to conduct projects in the Brew lab in 2025.