Professor Michael John Rogers
Conjoint Professor

Professor Michael John Rogers

1994:     PhD in bone research. Dept of Molecular Biology & Biotechnology, Dept of Human Metabolism & Clinical Biochemistry, and Dept of Chemistry, University of Sheffield, UK.

1989:     BSc (1st Class Hons) in Biochemistry. Dept of Molecular Biology & Biotechnology, University of Sheffield, UK.

medicine-health
St Vincent's Clinical School

Mike graduated from the University of Sheffield, UK, in 1989 with a first class honours in Biochemistry and in 1994 with a PhD in bone pharmacology. After postdoctoral studies in Sheffield he moved to the University of Aberdeen, Scotland. In 1997 he was appointed Professor of Musculoskeletal Pharmacology and from 2005-2010 he led the Musculoskeletal Research Programme, recognised as a Centre of Excellence by the European League Against Rheumatism. Mike relocated to the Garvan Institute in Sydney 2012 to establish and lead the Bone Therapeutics Group within the Healthy Ageing Theme.

Mike's ground-breaking research elucidated the mechanisms of action of bisphosphonates, a blockbuster class of anti-resorptive drug used worldwide and the gold standard treatment for osteoporosis, bone metastases, childhood bone disorders and other skeletal diseases. His work identified two classes of bisphosphonate drug with distinct mechanisms of action and transformed understanding of bisphosphonate pharmacology. These findings provided an explanation for the adverse effects of bisphosphonates and offer new insights into the possible mechanisms underlying pleiotropic effects of bisphosphonates on tumour growth and mortality. His research continues to focus on the anti-cancer and immune-modulatory actions of bisphosphonates, as well as autoinflammatory disorders that have mechanistic similarities to the actions of bisphosphonate drugs. He has strong links with the pharmaceutical industry, served on various Editorial Boards including Bone and Journal of Endocrinology, numerous grant and fellowship committees, the Board of Directors of the International Bone & Mineral Society and the committee of the UK Bone Research Society. He has published more than 90 papers and 38 reviews and book chapters, with >15,000 citations.

Phone
02 9295 8273

Publications

  • Book Chapters | 2020
    Professor Michael John Rogers
    Munoz MA; Rogers MJ, 2020, 'Bisphosphonates and Bone Cells—Molecular Mechanisms', in Encyclopedia of Bone Biology, Elsevier, pp. 565 - 578, http://dx.doi.org/10.1016/b978-0-12-801238-3.11261-9
    Book Chapters | 2020
    Professor Michael John Rogers
    Cremers S; Drake MT; Ebetino FH; Rogers MJ; Bilezikian JP; Russell RGG, 2020, 'Chapter 72 Clinical and translational pharmacology of bisphosphonates', in Principles of Bone Biology, pp. 1671 - 1687, http://dx.doi.org/10.1016/b978-0-12-814841-9.00072-5
    Book Chapters | 2019
    Professor Michael John Rogers
    Cremers S; Drake MT; Ebetino FH; Rogers MJ; Bilezikian JP; Russell RG, 2019, 'Clinical and translational pharmacology of bisphosphonates', in Principles of Bone Biology, pp. 1671 - 1687, http://dx.doi.org/10.1016/B978-0-12-814841-9.00072-5
    Book Chapters | 2015
    Professor Michael John Rogers
    Junankar S; Rogers MJ, 2015, 'Chapter 51 Cellular and molecular actions of bisphosphonates', in Bone Cancer, pp. 615 - 627, http://dx.doi.org/10.1016/b978-0-12-416721-6.00051-0
    Book Chapters | 2014
    Professor Michael John Rogers
    Junankar S; Rogers MJ, 2014, 'Cellular and molecular actions of bisphosphonates', in Bone Cancer: Primary Bone Cancers and Bone Metastases: Second Edition, Elsevier/Academic Press, San Diego, California, pp. 615 - 627, http://dx.doi.org/10.1016/B978-0-12-416721-6.00051-0
    Book Chapters | 2008
    Professor Michael John Rogers
    Roelofs AJ; Ebetino FH; Reszka AA; Russell RGG; Rogers MJ, 2008, 'Chapter 81 Bisphosphonates Mechanisms of Action', in Principles of Bone Biology, pp. 1737 - 1767, http://dx.doi.org/10.1016/b978-0-12-373884-4.00095-1
    Book Chapters | 2008
    Professor Michael John Rogers
    Roelofs AJ; Ebetino FH; Reszka AA; Russell RGG; Rogers MJ, 2008, 'Bisphosphonates: Mechanisms of Action', in Principles of Bone Biology, Two-Volume Set, pp. 1737 - 1767, http://dx.doi.org/10.1016/B978-0-12-373884-4.00095-1
    Book Chapters | 2006
    Professor Michael John Rogers
    Coleman RE; Rogers MJ, 2006, 'Mechanisms of Action of Bisphosphonates', in Textbook of Bone Metastases, pp. 323 - 343, http://dx.doi.org/10.1002/0470011610.ch25
    Book Chapters | 2005
    Professor Michael John Rogers
    McGowan NWA; Harmey D; Coxon FP; Stenbeck G; Rogers MJ; Grigoriadis AE, 2005, 'Bacterial toxins and bone remodelling', in Bacterial Protein Toxins, Cambridge University Press, pp. 147 - 168, http://dx.doi.org/10.1017/cbo9780511546280.008
    Book Chapters | 2003
    Professor Michael John Rogers
    Coxon FP; Frith JC; Benford HL; Rogers MJ, 2003, 'Isolation and Purification of Rabbit Osteoclasts', in Bone Research Protocols, pp. 89 - 99, http://dx.doi.org/10.1385/1-59259-366-6:89
    Book Chapters | 2002
    Professor Michael John Rogers
    Fleisch H; Reszka A; Rodan G; Rogers M, 2002, 'Bisphosphonates', in Principles of Bone Biology, Elsevier, pp. 1361 - XLIII, http://dx.doi.org/10.1016/b978-012098652-1.50180-3
    Book Chapters | 1996
    Professor Michael John Rogers
    Rogers MJ; Russell RGG, 1996, 'Mechanisms of Action of Bisphosphonates as Inhibitors of Bone Resorption', in Medical Intelligence Unit, Springer Berlin Heidelberg, pp. 147 - 177, http://dx.doi.org/10.1007/978-3-662-22505-9_7
  • Journal articles | 2021
    Professor Michael John Rogers
    McDonald MM; Khoo WH; Ng PY; Xiao Y; Zamerli J; Thatcher P; Kyaw W; Pathmanandavel K; Grootveld AK; Moran I; Butt D; Nguyen A; Warren S; Biro M; Butterfield NC; Guilfoyle SE; Komla-Ebri D; Dack MRG; Dewhurst HF; Logan JG; Li Y; Mohanty ST; Byrne N; Terry RL; Simic MK; Chai R; Quinn JMW; Youlten SE; Pettitt JA; Abi-Hanna D; Jain R; Weninger W; Lundberg M; Sun S; Ebetino FH; Timpson P; Lee WM; Baldock PA; Rogers MJ; Brink R; Williams GR; Bassett JHD; Kemp JP; Pavlos NJ; Croucher PI; Phan TG, 2021, 'Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption', Cell, vol. 184, pp. 1330 - 1347.e13, http://dx.doi.org/10.1016/j.cell.2021.02.002
    Journal articles | 2021
    Professor Michael John Rogers
    McDonald MM; Khoo WH; Ng PY; Xiao Y; Zamerli J; Thatcher P; Kyaw W; Pathmanandavel K; Grootveld AK; Moran I; Butt D; Nguyen A; Corr A; Warren S; Biro M; Butterfield NC; Guilfoyle SE; Komla-Ebri D; Dack MRG; Dewhurst HF; Logan JG; Li Y; Mohanty ST; Byrne N; Terry RL; Simic MK; Chai R; Quinn JMW; Youlten SE; Pettitt JA; Abi-Hanna D; Jain R; Weninger W; Lundberg M; Sun S; Ebetino FH; Timpson P; Lee WM; Baldock PA; Rogers MJ; Brink R; Williams GR; Bassett JHD; Kemp JP; Pavlos NJ; Croucher PI; Phan TG, 2021, 'Erratum: Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption (Cell (2021) 184(5) (1330–1347.e13), (S0092867421001525), (10.1016/j.cell.2021.02.002))', Cell, vol. 184, pp. 1940, http://dx.doi.org/10.1016/j.cell.2021.03.010
    Journal articles | 2021
    Professor Michael John Rogers
    Kamble S; Valtchev P; Dao A; Pelras T; Rogers MJ; Savage PB; Dehghani F; Schindeler A, 2021, 'Synthesis and characterization of bone binding antibiotic-1 (Bba-1), a novel antimicrobial for orthopedic applications', Molecules, vol. 26, http://dx.doi.org/10.3390/molecules26061541
    Journal articles | 2020
    Professor Michael John Rogers
    Brown AJ; Sharpe LJ; Rogers MJ, 2020, 'Oxysterols: From physiological tuners to pharmacological opportunities', British Journal of Pharmacology, http://dx.doi.org/10.1111/bph.15073
    Journal articles | 2020
    Professor Michael John Rogers
    Rogers MJ; Mönkkönen J; Munoz MA, 2020, 'Molecular mechanisms of action of bisphosphonates and new insights into their effects outside the skeleton', Bone, vol. 139, pp. 115493, http://dx.doi.org/10.1016/j.bone.2020.115493
    Journal articles | 2019
    Professor Michael John Rogers
    Skinner OP; Jurczyluk J; Baker PJ; Masters SL; Rios Wilks AG; Clearwater MS; Robertson AAB; Schroder K; Mehr S; Munoz MA; Rogers MJ, 2019, 'Lack of protein prenylation promotes NLRP3 inflammasome assembly in human monocytes', Journal of Allergy and Clinical Immunology, vol. 143, pp. 2315 - 2317.e3, http://dx.doi.org/10.1016/j.jaci.2019.02.013
    Journal articles | 2019
    Professor Michael John Rogers
    Munoz MA; Jurczyluk J; Simon A; Hissaria P; Arts RJW; Coman D; Boros C; Mehr S; Rogers MJ, 2019, 'Defective protein prenylation in a spectrum of patients with mevalonate kinase deficiency', Frontiers in Immunology, vol. 10, http://dx.doi.org/10.3389/fimmu.2019.01900
    Journal articles | 2019
    Professor Michael John Rogers
    Lee NJ; Ali N; Zhang L; Qi Y; Clarke I; Enriquez RF; Brzozowska M; Lee IC; Rogers MJ; Laybutt DR; Center JR; Baldock PA; Herzog H, 2019, 'Osteoglycin, a novel coordinator of bone and glucose homeostasis', Obesity Research & Clinical Practice, vol. 13, pp. 256 - 256, http://dx.doi.org/10.1016/j.orcp.2018.11.063
    Journal articles | 2018
    Professor Michael John Rogers
    Rogers MJ; Munoz MA, 2018, 'From vesicle to cytosol', eLife, vol. 7, http://dx.doi.org/10.7554/eLife.38847
    Journal articles | 2018
    Professor Michael John Rogers
    Lee NJ; Ali N; Qi J; Clarke RF; Enriquez RF; Brzozowska M; Lee IC; Rogers MJ; Laybutt DR; Center JR; Baldock PA; Herzog H, 2018, 'Osteoglycin, an Osteoblast-derived Regulator of Bone Mass and Glucose Homeostasis', Molecular Metabolism, vol. 13, pp. 30 - 44, http://dx.doi.org/10.1016/j.molmet.2018.05.004
    Journal articles | 2017
    Professor Michael John Rogers
    Chai RC; McDonald MM; Terry RL; Kovacic N; Down JM; Pettitt JA; Mohanty ST; Shah S; Haffari G; Xu J; Gillespie MT; Rogers MJ; Price JT; Croucher PI; Quinn JMW, 2017, 'Melphalan modifies the bone microenvironment by enhancing osteoclast formation', ONCOTARGET, vol. 8, pp. 68047 - 68058, http://dx.doi.org/10.18632/oncotarget.19152
    Journal articles | 2017
    Professor Michael John Rogers
    Munoz MA; Jurczyluk J; Mehr S; Chai RC; Arts RJW; Sheu A; McMahon C; Center JR; Singh-Grewal D; Chaitow J; Campbell DE; Quinn JMW; Alexandrov K; Tnimov Z; Tangye SG; Simon A; Phan TG; Rogers MJ, 2017, 'Defective protein prenylation is a diagnostic biomarker of mevalonate kinase deficiency', Journal of Allergy and Clinical Immunology, vol. 140, pp. 873 - 875.e6, http://dx.doi.org/10.1016/j.jaci.2017.02.033
    Journal articles | 2016
    Professor Michael John Rogers
    Jurczyluk J; Munoz MA; Skinner OP; Chai RC; Ali N; Palendira U; Quinn JMW; Preston A; Tangye SG; Brown AJ; Argent E; Ziegler JB; Mehr S; Rogers MJ, 2016, 'Mevalonate kinase deficiency leads to decreased prenylation of Rab GTPases', Immunology and Cell Biology, vol. 94, pp. 994 - 999, http://dx.doi.org/10.1038/icb.2016.58
    Journal articles | 2016
    Professor Michael John Rogers
    Jurczyluk J; Munoz MA; Skinner OP; Chai RC; Ali N; Palendira U; Quinn JMW; Preston A; Tangye SG; Brown AJ; Argent E; Ziegler JB; Mehr S; Rogers MJ, 2016, 'Mevalonate kinase deficiency leads to decreased prenylation of Rab GTPases', IMMUNOLOGY AND CELL BIOLOGY, vol. 94, pp. 994 - 999, http://dx.doi.org/10.1038/icb.2016.58
    Journal articles | 2015
    Professor Michael John Rogers
    Ali N; Jurczyluk J; Shay G; Tnimov Z; Alexandrov K; Munoz MA; Skinner OP; Pavlos NJ; Rogers MJ, 2015, 'A highly sensitive prenylation assay reveals in vivo effects of bisphosphonate drug on the Rab prenylome of macrophages outside the skeleton', Small GTPases, vol. 6, pp. 202 - 211, http://dx.doi.org/10.1080/21541248.2015.1085485
    Journal articles | 2015
    Professor Michael John Rogers
    Junankar S; Shay G; Jurczyluk J; Ali N; Down J; Pocock N; Parker A; Nguyen A; Sun S; Kashemirov B; McKenna CE; Croucher PI; Swarbrick A; Weilbaecher K; Phan TG; Rogers MJ, 2015, 'Real-Time Intravital Imaging Establishes Tumor-Associated Macrophages as the Extraskeletal Target of Bisphosphonate Action in Cancer', Cancer Discovery, vol. 5, pp. 35 - 42, http://dx.doi.org/10.1158/2159-8290.CD-14-0621
    Journal articles | 2015
    Professor Michael John Rogers
    Lawson MA; McDonald MM; Kovacic N; Khoo WH; Terry RL; Down J; Kaplan W; Paton-Hough J; Fellows C; Pettitt JA; Dear TN; Van Valckenborgh E; Baldock PA; Rogers MJ; Eaton CL; Vanderkerken K; Pettit AR; Quinn JMW; Zannettino ACW; Phan TG; Croucher PI, 2015, 'Osteoclasts control reactivation of dormant myeloma cells by remodelling the endosteal niche', Nature Communications, vol. 6, http://dx.doi.org/10.1038/ncomms9983
    Journal articles | 2015
    Professor Michael John Rogers
    Croucher PI; Parker BS; Corcoran N; Rogers MJ, 2015, 'Bone turnover markers and prostate cancer: Not just a measure of bone disease?', European Urology, vol. 68, pp. 51 - 52, http://dx.doi.org/10.1016/j.eururo.2014.10.041
    Journal articles | 2014
    Professor Michael John Rogers
    Das S; Edwards PA; Crockett JC; Rogers MJ, 2014, 'Upregulation of endogenous farnesyl diphosphate synthase overcomes the inhibitory effect of bisphosphonate on protein prenylation in Hela cells', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, vol. 1841, pp. 569 - 573, http://dx.doi.org/10.1016/j.bbalip.2013.12.010
    Journal articles | 2013
    Professor Michael John Rogers
    Rumpler M; Würger T; Roschger P; Zwettler E; Sturmlechner I; Altmann P; Fratzl P; Rogers MJ; Klaushofer K, 2013, 'Osteoclasts on bone and dentin in vitro: Mechanism of trail formation and comparison of resorption behavior', Calcified Tissue International, vol. 93, pp. 526 - 539, http://dx.doi.org/10.1007/s00223-013-9786-7
    Journal articles | 2012
    Professor Michael John Rogers
    Coxon FP; Rogers MJ; Crockett JC, 2012, 'Isolation and purification of rabbit osteoclasts', Methods in Molecular Biology, vol. 816, pp. 145 - 158, http://dx.doi.org/10.1007/978-1-61779-415-5_10
    Journal articles | 2012
    Professor Michael John Rogers
    Roelofs AJ; Stewart CA; Sun S; Błazewska KM; Kashemirov BA; McKenna CE; Russell RGG; Rogers MJ; Lundy MW; Ebetino FH; Coxon FP, 2012, 'Influence of bone affinity on the skeletal distribution of fluorescently labeled bisphosphonates in vivo', Journal of Bone and Mineral Research, vol. 27, pp. 835 - 847, http://dx.doi.org/10.1002/jbmr.1543
    Journal articles | 2012
    Professor Michael John Rogers
    Whyte LS; Ford L; Ridge SA; Cameron GA; Rogers MJ; Ross RA, 2012, 'Cannabinoids and bone: Endocannabinoids modulate human osteoclast function in vitro', British Journal of Pharmacology, vol. 165, pp. 2584 - 2597, http://dx.doi.org/10.1111/j.1476-5381.2011.01519.x
    Journal articles | 2012
    Professor Michael John Rogers
    Hughes A; Kleine-Albers J; Helfrich MH; Ralston SH; Rogers MJ, 2012, 'A Class III semaphorin (Sema3e) inhibits mouse osteoblast migration and decreases osteoclast formation in vitro', Calcified Tissue International, vol. 90, pp. 151 - 162, http://dx.doi.org/10.1007/s00223-011-9560-7
    Journal articles | 2012
    Professor Michael John Rogers
    Naylor AJ; Azzam E; Smith S; Croft A; Poyser C; Duffield JS; Huso DL; Gay S; Ospelt C; Cooper MS; Isacke C; Goodyear SR; Rogers MJ; Buckley CD, 2012, 'The mesenchymal stem cell marker CD248 (Endosialin) is a negative regulator of bone formation in mice', Arthritis and Rheumatism, vol. 64, pp. 3334 - 3343, http://dx.doi.org/10.1002/art.34556
    Journal articles | 2012
    Professor Michael John Rogers
    Su X; Floyd DH; Hughes A; Xiang J; Schneider JG; Uluckan O; Heller E; Deng H; Zou W; Craft CS; Wu K; Hirbe AC; Grabowska D; Eagleton MC; Townsley S; Collins L; Piwnica-Worms D; Steinberg TH; Novack DV; Conley PB; Hurchla MA; Rogers M; Weilbaecher KN, 2012, 'The ADP receptor P2RY12 regulates osteoclast function and pathologic bone remodeling', Journal of Clinical Investigation, vol. 122, pp. 3579 - 3592, http://dx.doi.org/10.1172/JCI38576
    Journal articles | 2012
    Professor Michael John Rogers
    Moriceau G; Roelofs AJ; Brion R; Redini F; Ebetion FH; Rogers MJ; Heymann D, 2012, 'Synergistic inhibitory effect of apomine and lovastatin on osteosarcoma cell growth', Cancer, vol. 118, pp. 750 - 760, http://dx.doi.org/10.1002/cncr.26336
    Journal articles | 2011
    Professor Michael John Rogers
    Itzstein C; Coxon FP; Rogers MJ, 2011, 'The regulation of osteoclast function and bone resorption by small GTPases', Small GTPases, vol. 2, pp. 117 - 130, http://dx.doi.org/10.4161/sgtp.2.3.16453
    Journal articles | 2011
    Professor Michael John Rogers
    Thompson K; Keech F; McLernon DJ; Vinod K; May RJ; Simpson WG; Rogers MJ; Reid DM, 2011, 'Fluvastatin does not prevent the acute-phase response to intravenous zoledronic acid in post-menopausal women', Bone, vol. 49, pp. 140 - 145, http://dx.doi.org/10.1016/j.bone.2010.10.177
    Journal articles | 2011
    Professor Michael John Rogers
    Błaewska KM; Ni F; Haiges R; Kashemirov BA; Coxon FP; Stewart CA; Baron R; Rogers MJ; Seabra MC; Ebetino FH; McKenna CE, 2011, 'Synthesis, stereochemistry and SAR of a series of minodronate analogues as RGGT inhibitors', European Journal of Medicinal Chemistry, vol. 46, pp. 4820 - 4826, http://dx.doi.org/10.1016/j.ejmech.2011.04.063
    Journal articles | 2011
    Professor Michael John Rogers
    Rogers MJ; Crockett JC; Coxon FP; Mönkkönen J, 2011, 'Biochemical and molecular mechanisms of action of bisphosphonates', Bone, vol. 49, pp. 34 - 41, http://dx.doi.org/10.1016/j.bone.2010.11.008
    Journal articles | 2011
    Professor Michael John Rogers
    Taylor A; Mules EH; Seabra MC; Helfrich MH; Rogers MJ; Coxon FP, 2011, 'Impaired prenylation of Rab GTPases in the gunmetal mouse causes defects in bone cell function', Small GTPases, vol. 2, pp. 131 - 142, http://dx.doi.org/10.4161/sgtp.2.3.16488
    Journal articles | 2011
    Professor Michael John Rogers
    Crockett JC; Mellis DJ; Shennan KIJ; Duthie A; Greenhorn J; Wilkinson DI; Ralston SH; Helfrich MH; Rogers MJ, 2011, 'Signal peptide mutations in RANK prevent downstream activation of NF-κB', Journal of Bone and Mineral Research, vol. 26, pp. 1926 - 1938, http://dx.doi.org/10.1002/jbmr.399
    Journal articles | 2011
    Professor Michael John Rogers
    Crockett JC; Rogers MJ; Coxon FP; Hocking LJ; Helfrich MH, 2011, 'Bone remodelling at a glance', Journal of Cell Science, vol. 124, pp. 991 - 998, http://dx.doi.org/10.1242/jcs.063032
    Journal articles | 2011
    Professor Michael John Rogers
    Coxon FP; Taylor A; Stewart CA; Baron R; Seabra MC; Ebetino FH; Rogers MJ, 2011, 'The gunmetal mouse reveals Rab geranylgeranyl transferase to be the major molecular target of phosphonocarboxylate analogues of bisphosphonates', Bone, vol. 49, pp. 111 - 121, http://dx.doi.org/10.1016/j.bone.2011.03.686
    Journal articles | 2011
    Professor Michael John Rogers
    Das⁎ S; Crockett JC; Rogers MJ, 2011, 'Upregulation of endogenous FPP synthase in cultured cells causes resistance to bisphosphonate', Bone, vol. 48, pp. S231 - S231, http://dx.doi.org/10.1016/j.bone.2011.03.549
    Journal articles | 2011
    Professor Michael John Rogers
    Mellis⁎ DJG; Duthie A; Rogers MJ; Helfrich MH; Crockett JC, 2011, 'Assessment of signalling downstream of the mutant rank protein that causes familial expansile osteolysis', Bone, vol. 48, pp. S128 - S128, http://dx.doi.org/10.1016/j.bone.2011.03.251
    Journal articles | 2010
    Professor Michael John Rogers
    Roelofs AJ; Thompson K; Ebetino FH; Rogers MJ; Coxon FP, 2010, 'Bisphosphonates: Molecular mechanisms of action and effects on bone cells, monocytes and macrophages', Current Pharmaceutical Design, vol. 16, pp. 2950 - 2960, http://dx.doi.org/10.2174/138161210793563635
    Journal articles | 2010
    Professor Michael John Rogers
    McKenna CE; Kashemirov BA; Błazewska KM; Mallard-Favier I; Stewart CA; Rojas J; Lundy MW; Ebetino FH; Baron RA; Dunford JE; Kirsten ML; Seabra MC; Bala JL; Marma MS; Rogers MJ; Coxon FP, 2010, 'Synthesis, chiral high performance liquid chromatographic resolution and enantiospecific activity of a potent new geranylgeranyl transferase inhibitor, 2-hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosphonopropionic Acid', Journal of Medicinal Chemistry, vol. 53, pp. 3454 - 3464, http://dx.doi.org/10.1021/jm900232u
    Journal articles | 2010
    Professor Michael John Rogers
    Guenther A; Gordon S; Tiemann M; Burger R; Bakker F; Green JR; Baum W; Roelofs AJ; Rogers MJ; Gramatzki M, 2010, 'The bisphosphonate zoledronic acid has antimyeloma activity in vivo by inhibition of protein prenylation', International Journal of Cancer, vol. 126, pp. 239 - 246, http://dx.doi.org/10.1002/ijc.24758
    Journal articles | 2010
    Professor Michael John Rogers
    Roelofs AJ; Coxon FP; Ebetino FH; Lundy MW; Henneman ZJ; Nancollas GH; Sun S; Blazewska KM; Bala JLF; Kashemirov BA; Khalid AB; McKenna CE; Rogers MJ, 2010, 'Fluorescent risedronate analogues reveal bisphosphonate uptake by bone marrow monocytes and localization around osteocytes in vivo', Journal of Bone and Mineral Research, vol. 25, pp. 606 - 616, http://dx.doi.org/10.1359/jbmr.091009
    Journal articles | 2010
    Professor Michael John Rogers
    Ford LA; Roelofs AJ; Anavi-Goffer S; Mowat L; Simpson DG; Irving AJ; Rogers MJ; Rajnicek AM; Ross RA, 2010, 'A role for L-α-lysophosphatidylinositol and GPR55 in the modulation of migration, orientation and polarization of human breast cancer cells', British Journal of Pharmacology, vol. 160, pp. 762 - 771, http://dx.doi.org/10.1111/j.1476-5381.2010.00743.x
    Journal articles | 2010
    Professor Michael John Rogers
    Hocking LJ; Mellis DJ; McCabe PS; Helfrich MH; Rogers MJ, 2010, 'Functional interaction between Sequestosome-1/p62 and Autophagy-Linked FYVE-containing protein WDFY3 in human osteoclasts', Biochemical and Biophysical Research Communications, vol. 402, pp. 543 - 548, http://dx.doi.org/10.1016/j.bbrc.2010.10.076
    Journal articles | 2010
    Professor Michael John Rogers
    Mellis DJ; Das S; Helfrich M; Rogers MJ; Crockett JC, 2010, 'A mutation that prevents rank trimer formation does not prevent signalling downstream of rank', Bone, vol. 47, pp. S137 - S138, http://dx.doi.org/10.1016/j.bone.2010.04.310
    Journal articles | 2010
    Professor Michael John Rogers
    Itzstein⁎ C; Taylor A; Coxon FP; Rogers MJ, 2010, 'The small GTPase Rab14 is required for osteoclast polarisation and bone resorption', Bone, vol. 47, pp. S67 - S67, http://dx.doi.org/10.1016/j.bone.2010.04.129
    Journal articles | 2010
    Professor Michael John Rogers
    Coxon F; Roelofs A; Boyde A; Lundy M; McKenna C; Blazewska K; Sun S; Kashemirov B; Duan X; Russell G; Khalid A; Rogers M; Ebetino F, 2010, 'The Ability of Bisphosphonates and Their Analogues to Penetrate the Osteocyte Network is Dependent on Affinity for Bone', Bone, vol. 46, pp. S22 - S22, http://dx.doi.org/10.1016/j.bone.2010.01.041
    Journal articles | 2010
    Professor Michael John Rogers
    Hughes A; Crombie P; Tosh D; Coxon F; Aspden RM; Helfrich M; Rogers MJ, 2010, 'Expression, activation and regulation of the small GTPase Rap1 in bone cells', Bone, vol. 47, pp. S139 - S140, http://dx.doi.org/10.1016/j.bone.2010.04.315
    Journal articles | 2010
    Professor Michael John Rogers
    Khalid A; Goodyear S; Rogers M; Ross R; Aspden R, 2010, 'Loss of the cannabinoid receptor CB2 alters the mechanical but not the material properties of bone', Bone, vol. 47, pp. S85 - S86, http://dx.doi.org/10.1016/j.bone.2010.04.172
    Journal articles | 2009
    Professor Michael John Rogers
    Räikkönen J; Crockett JC; Rogers MJ; Mönkkönen H; Auriola S; Mönkkönen J, 2009, 'Zoledronic acid induces formation of a pro-apoptotic ATP analogue and isopentenyl pyrophosphate in osteoclasts in vivo and in MCF-7 cells in vitro', British Journal of Pharmacology, vol. 157, pp. 427 - 435, http://dx.doi.org/10.1111/j.1476-5381.2009.00160.x
    Journal articles | 2009
    Professor Michael John Rogers
    Baron RA; Tavaré R; Figueiredo AC; Błazewska KM; Kashemirov BA; McKenna CE; Ebetino FH; Taylor A; Rogers MJ; Coxon FP; Seabra MC, 2009, 'Phosphonocarboxylates inhibit the second geranylgeranyl addition by Rab geranylgeranyl transferase', Journal of Biological Chemistry, vol. 284, pp. 6861 - 6868, http://dx.doi.org/10.1074/jbc.M806952200
    Journal articles | 2009
    Professor Michael John Rogers
    Sutherland KA; Rogers HL; Tosh D; Rogers MJ, 2009, 'RANKL increases the level of Mcl-1 in osteoclasts and reduces bisphosphonate-induced osteoclast apoptosis in vitro', Arthritis Research and Therapy, vol. 11, http://dx.doi.org/10.1186/ar2681
    Journal articles | 2009
    Professor Michael John Rogers
    Roelofs AJ; Jauhiainen M; Mönkkönen H; Rogers MJ; Mönkkönen J; Thompson K, 2009, 'Peripheral blood monocytes are responsible for γδ T cell activation induced by zoledronic acid through accumulation of IPP/DMAPP', British Journal of Haematology, vol. 144, pp. 245 - 250, http://dx.doi.org/10.1111/j.1365-2141.2008.07435.x
    Journal articles | 2009
    Professor Michael John Rogers
    Whyte LS; Ryberg E; Sims NA; Ridge SA; Mackie K; Greasley PJ; Ross RA; Rogers MJ, 2009, 'The putative cannabinoid receptor GPR55 affects osteoclast function in vitro and bone mass in vivo', Proceedings of the National Academy of Sciences of the United States of America, vol. 106, pp. 16511 - 16516, http://dx.doi.org/10.1073/pnas.0902743106
    Journal articles | 2009
    Professor Michael John Rogers
    Hirbe AC; Roelofs AJ; Floyd DH; Deng H; Becker SN; Lanigan LG; Apicelli AJ; Xu Z; Prior JL; Eagleton MC; Piwnica-Worms D; Rogers MJ; Weilbaecher K, 2009, 'The bisphosphonate zoledronic acid decreases tumor growth in bone in mice with defective osteoclasts', Bone, vol. 44, pp. 908 - 916, http://dx.doi.org/10.1016/j.bone.2009.01.010
    Journal articles | 2009
    Professor Michael John Rogers
    Whyte L; Ryberg E; Sims NA; Ridge S; Mackie K; Greasley P; Ross RA; Rogers MJ, 2009, 'GPR55: A novel cannabinoid receptor involved in the regulation of osteoclast function and bone mass', Bone, vol. 44, pp. S138 - S138, http://dx.doi.org/10.1016/j.bone.2009.01.305
    Journal articles | 2009
    Professor Michael John Rogers
    Roelofs AJ; Boyde A; Lundy MW; McKenna CE; Blazewska K; Sun ST; Kashemirov BA; Russell RGG; Ebetino FH; Rogers MJ; Coxon FP, 2009, 'Bone mineral affinity influences the distribution of a bisphosphonate and a lower affinity analogue in vivo', Bone, vol. 44, pp. S430 - S431, http://dx.doi.org/10.1016/j.bone.2009.03.377
    Journal articles | 2009
    Professor Michael John Rogers
    Boyde A; Lundy MW; Coxon FP; McKenna CE; Roelofs A; Bala J; Rogers MJ; Blazewska K; Russell RGG; Ebetino FH, 2009, 'The differential distribution in vivo of fluorescently-labeled bisphosphonate analogues with different mineral affinity to bone surfaces', Bone, vol. 44, pp. S57 - S57, http://dx.doi.org/10.1016/j.bone.2009.01.016
    Journal articles | 2009
    Professor Michael John Rogers
    Thompson K; Keech F; McLernon D; Vinod K; Tosh D; Simpson WG; Rogers MJ; Reid DM, 2009, 'Fluvastatin does not prevent the acute-phase response to intravenous zoledronic acid in post-menopausal women', Bone, vol. 44, pp. S236 - S237, http://dx.doi.org/10.1016/j.bone.2009.03.093
    Journal articles | 2009
    Professor Michael John Rogers
    Moriceau G; Roelofs AJ; Brion R; Ebetino HF; Rogers M; Heymann D, 2009, 'Synergistic effect of apomine and lovastatin on osteosarcoma cell growth', Bone, vol. 44, pp. S273 - S273, http://dx.doi.org/10.1016/j.bone.2009.03.479
    Journal articles | 2009
    Professor Michael John Rogers
    Mellis DJ; Guerrini MM; Greenhorn J; Vezzoni P; Villa A; Rogers MJ; Helfrich MH; Crockett JC, 2009, 'Functional analysis of mutations in rank that result in diseases with opposite phenotypes', Bone, vol. 44, pp. S325 - S325, http://dx.doi.org/10.1016/j.bone.2009.03.617
    Journal articles | 2008
    Professor Michael John Rogers
    Kashemirov BA; Bala JLF; Chen X; Ebetino FH; Xia Z; Russell RGG; Coxon FP; Roelofs AJ; Rogers MJ; McKenna CE, 2008, 'Fluorescently labeled risedronate and related analogues: "Magic linker" synthesis', Bioconjugate Chemistry, vol. 19, pp. 2308 - 2310, http://dx.doi.org/10.1021/bc800369c
    Journal articles | 2008
    Professor Michael John Rogers
    Dunford JE; Kwaasi AA; Rogers MJ; Barnett BL; Ebetino FH; Russell RGG; Oppermann U; Kavanagh KL, 2008, 'Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: Time-dependent inhibition of human farnesyl pyrophosphate synthase', Journal of Medicinal Chemistry, vol. 51, pp. 2187 - 2195, http://dx.doi.org/10.1021/jm7015733
    Journal articles | 2008
    Professor Michael John Rogers
    Coxon FP; Thompson K; Roelofs AJ; Ebetino FH; Rogers MJ, 2008, 'Visualizing mineral binding and uptake of bisphosphonate by osteoclasts and non-resorbing cells', Bone, vol. 42, pp. 848 - 860, http://dx.doi.org/10.1016/j.bone.2007.12.225
    Journal articles | 2008
    Professor Michael John Rogers
    Fournier PGJ; Daubiné F; Lundy MW; Rogers MJ; Ebetino FH; Clézardin P, 2008, 'Lowering bone mineral affinity of bisphosphonates as a therapeutic strategy to optimize skeletal tumor growth inhibition in vivo', Cancer Research, vol. 68, pp. 8945 - 8953, http://dx.doi.org/10.1158/0008-5472.CAN-08-2195
    Journal articles | 2008
    Professor Michael John Rogers
    Guerrini MM; Sobacchi C; Cassani B; Abinun M; Kilic SS; Pangrazio A; Moratto D; Mazzolari E; Clayton-Smith J; Orchard P; Coxon FP; Helfrich MH; Crockett JC; Mellis D; Vellodi A; Tezcan I; Notarangelo LD; Rogers MJ; Vezzoni P; Villa A; Frattini A, 2008, 'Human Osteoclast-Poor Osteopetrosis with Hypogammaglobulinemia due to TNFRSF11A (RANK) Mutations', American Journal of Human Genetics, vol. 83, pp. 64 - 76, http://dx.doi.org/10.1016/j.ajhg.2008.06.015
    Journal articles | 2008
    Professor Michael John Rogers
    Russell RGG; Watts NB; Ebetino FH; Rogers MJ, 2008, 'Mechanisms of action of bisphosphonates: Similarities and differences and their potential influence on clinical efficacy', Osteoporosis International, vol. 19, pp. 733 - 759, http://dx.doi.org/10.1007/s00198-007-0540-8
    Journal articles | 2008
    Professor Michael John Rogers
    Ory B; Moriceau G; Trichet V; Blanchard F; Berreur M; Rédini F; Rogers M; Heymann D, 2008, 'Farnesyl diphosphate synthase is involved in the resistance to zoledronic acid of osteosarcoma cells', Journal of Cellular and Molecular Medicine, vol. 12, pp. 928 - 941, http://dx.doi.org/10.1111/j.1582-4934.2008.00141.x
    Journal articles | 2008
    Professor Michael John Rogers
    Holmes S; Smith S; Borthwick L; Dunford J; Rogers M; Bishop N; Grabowski PS, 2008, 'CMT3 alters mitochondrial function in murine osteoclast lineage cells', Biochemical and Biophysical Research Communications, vol. 365, pp. 840 - 845, http://dx.doi.org/10.1016/j.bbrc.2007.11.054
    Journal articles | 2008
    Professor Michael John Rogers
    Ory B; Moriceau G; Trichet V; Blanchard F; Berreur M; Redini F; Rogers M; Heymann D, 2008, 'Farnesyl diphosphate synthase is involved in the resistance to zoledronic acid of osteosarcoma cells', JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, vol. 12, pp. 928 - 941, http://dx.doi.org/10.1111/j.1582-4934.2008.00141.x
    Journal articles | 2008
    Professor Michael John Rogers
    Guerrini MM; Sobacchi C; Cassani B; Abinun M; Kilic SS; Pangrazio A; Moratto D; Mazzolari E; Clayton-Smith J; Orchard P; Coxon FP; Helfrich MH; Crockett JC; Mellis D; Vellodi A; Tezcan I; Notarangelo LD; Rogers MJ; Vezzoni P; Villa A; Frattini A, 2008, 'Human osteoclast-poor osteopetrosis with hypogammaglobulinemia due to TNFRSF11A (RANK) mutations', AMERICAN JOURNAL OF HUMAN GENETICS, vol. 83, pp. 64 - 76, http://dx.doi.org/10.1016/j.ajhg.2008.06.015
    Journal articles | 2008
    Professor Michael John Rogers
    A. Stewart C; Baron R; Blazewska KM; Kashemirov BA; Ebetino FH; Navea JR; Rogers MJ; McKenna CE; Coxon FP, 2008, 'Differential inhibition of rab geranylgeranyl transferase by stereoisomers of phosphonocarboxylates', Bone, vol. 42, pp. S87 - S87, http://dx.doi.org/10.1016/j.bone.2007.12.164
    Journal articles | 2008
    Professor Michael John Rogers
    Kuokkanen J; Crockett JC; Rogers MJ; Mönkkönen H; Auriola S; Mönkkönen J, 2008, 'Zoledronic Acid-Induced IPP/ApppI Formation In Vivo and In Vitro', Bone, vol. 42, pp. S38 - S39, http://dx.doi.org/10.1016/j.bone.2007.12.060
    Journal articles | 2008
    Professor Michael John Rogers
    Roelofs AJ; Jauhiainen M; Monkkonen H; Rogers MJ; Monkkonen J; Thompson K, 2008, 'Nitrogen-containing bisphosphonates induce IPP/DMAPP accumulation selectively in peripheral blood monocytes due to efficient drug uptake', Bone, vol. 42, pp. S84 - S85, http://dx.doi.org/10.1016/j.bone.2007.12.159
    Journal articles | 2008
    Professor Michael John Rogers
    Coxon FP; Bala JL; Kashemirov BA; Lundy MW; Chen X; Xia Z; Dunford JE; Russell GG; Roelofs AJ; Rogers MJ; McKenna CE; Ebetino FH, 2008, 'Fluorescently labeled risedronate and related analogs: Design and evaluation as imaging probes', Bone, vol. 42, pp. S36 - S36, http://dx.doi.org/10.1016/j.bone.2007.12.054
    Journal articles | 2008
    Professor Michael John Rogers
    Tavare R; Baron R; Taylor A; Seabra MC; Blazewska KM; McKenna CE; Kashemirov BA; Ebetino FH; Rogers MJ; Coxon FP, 2008, 'Characterisation of the inhibition of rab prenylation by phosphonocarboxylates', Bone, vol. 42, pp. S88 - S89, http://dx.doi.org/10.1016/j.bone.2007.12.167
    Journal articles | 2008
    Professor Michael John Rogers
    Stewart CA; Baron R; Marma MS; Blazewska KM; Kashemirov BA; Ebetino FH; McKenna CE; Rogers MJ; Coxon FP, 2008, 'Structure activity relationships of phosphonocarboxylate inhibitors of rab geranylgeranyl transferase', Bone, vol. 42, pp. S86 - S87, http://dx.doi.org/10.1016/j.bone.2007.12.163
    Journal articles | 2008
    Professor Michael John Rogers
    Roelofs AJ; Coxon FP; Ebetino FH; Bala JF; Kashemirov BA; McKenna CE; Rogers MJ, 2008, 'Use of a fluorescent analogue of risedronate to study localisation and cellular uptake of bisphosphonates in vivo', Bone, vol. 42, pp. S85 - S85, http://dx.doi.org/10.1016/j.bone.2007.12.160
    Journal articles | 2008
    Professor Michael John Rogers
    Dunford JE; Kwaasi AA; Kavanagh KL; Rogers MJ; Oppermann U; Barnett BB; Ebetino FH; Graham R; Russell G, 2008, 'Structure activity relationships of nitrogen containing bisphosphonates which induce conformational changes in farnesyl pyrophosphate synthase', Bone, vol. 42, pp. S71 - S71, http://dx.doi.org/10.1016/j.bone.2007.12.129
    Journal articles | 2007
    Professor Michael John Rogers
    Taylor A; Rogers MJ; Tosh D; Coxon FP, 2007, 'A novel method for efficient generation of transfected human osteoclasts', Calcified Tissue International, vol. 80, pp. 132 - 136, http://dx.doi.org/10.1007/s00223-006-0245-6
    Journal articles | 2007
    Professor Michael John Rogers
    Roelofs AJ; Edwards CM; Russell RGG; Ebetino FH; Rogers MJ; Hulley PA, 2007, 'Apomine enhances the antitumor effects of lovastatin on myeloma cells by down-regulating 3-hydroxy-3-methylglutaryl-coenzyme A reductase', Journal of Pharmacology and Experimental Therapeutics, vol. 322, pp. 228 - 235, http://dx.doi.org/10.1124/jpet.106.116467
    Journal articles | 2007
    Professor Michael John Rogers
    Hughes A; Rogers MJ; Idris AI; Crockett JC, 2007, 'A comparison between the effects of hydrophobic and hydrophilic statins on osteoclast function in vitro and ovariectomy-induced bone loss in vivo', Calcified Tissue International, vol. 81, pp. 403 - 413, http://dx.doi.org/10.1007/s00223-007-9078-1
    Journal articles | 2007
    Professor Michael John Rogers
    Van Wesenbeeck L; Odgren PR; Coxon FP; Frattini A; Moens P; Perdu B; MacKay CA; Van Hul E; Timmermans JP; Vanhoenacker F; Jacobs R; Peruzzi B; Teti A; Helfrich MH; Rogers MJ; Villa A; Van Hul W, 2007, 'Involvement of PLEKHM1 in osteoclastic vesicular transport and osteopetrosis in incisors absent rats and humans', Journal of Clinical Investigation, vol. 117, pp. 919 - 930, http://dx.doi.org/10.1172/JCI30328
    Journal articles | 2007
    Professor Michael John Rogers
    Samanna V; Ma T; Mak TW; Rogers M; Chellaiah MA, 2007, 'Actin polymerization modulates CD44 surface expression, MMP-9 activation, and osteoclast function', Journal of Cellular Physiology, vol. 213, pp. 710 - 720, http://dx.doi.org/10.1002/jcp.21137
    Journal articles | 2007
    Professor Michael John Rogers
    Sobacchi C; Frattini A; Guerrini MM; Abinun M; Pangrazio A; Susani L; Bredius R; Mancini G; Cant A; Bishop N; Grabowski P; Del Fattore A; Messina C; Errigo G; Coxon FP; Scott DI; Teti A; Rogers MJ; Vezzoni P; Villa A; Helfrich MH, 2007, 'Osteoclast-poor human osteopetrosis due to mutations in the gene encoding RANKL', Nature Genetics, vol. 39, pp. 960 - 962, http://dx.doi.org/10.1038/ng2076
    Journal articles | 2007
    Professor Michael John Rogers
    Desai B; Rogers MJ; Chellaiah MA, 2007, 'Mechanisms of osteopontin and CD44 as metastatic principles in prostate cancer cells', Molecular Cancer, vol. 6, http://dx.doi.org/10.1186/1476-4598-6-18
    Journal articles | 2007
    Professor Michael John Rogers
    Crockett JC; Schütze N; Tosh D; Jatzke S; Duthie A; Jakob F; Rogers MJ, 2007, 'The matricellular protein CYR61 inhibits osteoclastogenesis by a mechanism independent of αvβ3 and α vβ5', Endocrinology, vol. 148, pp. 5761 - 5768, http://dx.doi.org/10.1210/en.2007-0473
    Journal articles | 2007
    Professor Michael John Rogers
    Thompson K; Rogers MJ, 2007, 'The molecular mechanisms of action of bisphosphonates', Clinical Reviews in Bone and Mineral Metabolism, vol. 5, pp. 130 - 144, http://dx.doi.org/10.1007/s12018-007-9004-0
    Journal articles | 2006
    Professor Michael John Rogers
    Coxon FP; Thompson K; Rogers MJ, 2006, 'Recent advances in understanding the mechanism of action of bisphosphonates', Current Opinion in Pharmacology, vol. 6, pp. 307 - 312, http://dx.doi.org/10.1016/j.coph.2006.03.005
    Journal articles | 2006
    Professor Michael John Rogers
    Dunford JE; Rogers MJ; Ebetino FH; Phipps RJ; Coxon FP, 2006, 'Inhibition of protein prenylation by bisphosphonates causes sustained activation of Rac, Cdc42, and Rho GTPases', Journal of Bone and Mineral Research, vol. 21, pp. 684 - 694, http://dx.doi.org/10.1359/jbmr.060118
    Journal articles | 2006
    Professor Michael John Rogers
    Kavanagh KL; Guo K; Dunford JE; Wu X; Knapp S; Ebetino FH; Rogers MJ; Russell RGG; Oppermann U, 2006, 'The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs', Proceedings of the National Academy of Sciences of the United States of America, vol. 103, pp. 7829 - 7834, http://dx.doi.org/10.1073/pnas.0601643103
    Journal articles | 2006
    Professor Michael John Rogers
    Thompson K; Rojas-Navea J; Rogers MJ, 2006, 'Alkylamines cause Vγ9Vδ2 T-cell activation and proliferation by inhibiting the mevalonate pathway', Blood, vol. 107, pp. 651 - 654, http://dx.doi.org/10.1182/blood-2005-03-1025
    Journal articles | 2006
    Professor Michael John Rogers
    Thompson K; Rogers MJ; Coxon FP; Crockett JC, 2006, 'Cytosolic entry of bisphosphonate drugs requires acidification of vesicles after fluid-phase endocytosis', Molecular Pharmacology, vol. 69, pp. 1624 - 1632, http://dx.doi.org/10.1124/mol.105.020776
    Journal articles | 2006
    Professor Michael John Rogers
    Roelofs AJ; Thompson K; Gordon S; Rogers MJ; Boyce ; Roodman ; Suva ; Coleman ; Weilbaecher ; Bruland ; Vessella ; Lipton , 2006, 'Molecular mechanisms of action of bisphosphonates: Current status', Clinical Cancer Research, vol. 12, http://dx.doi.org/10.1158/1078-0432.CCR-06-0843
    Journal articles | 2006
    Professor Michael John Rogers
    Kavanagh KL; Guo K; Wu X; Knapp S; Ebetino FH; Dunford JE; Rogers MJ; Russell RGG; Oppermann U, 2006, 'Crystal structures and molecular interactions of risedronate and zoledronate with human farnesyl diphosphate synthase', Bone, vol. 38, pp. 53 - 53, http://dx.doi.org/10.1016/j.bone.2005.12.050
    Journal articles | 2006
    Professor Michael John Rogers
    Coxon FP; Dunford JE; Rogers MJ, 2006, 'Inhibition of post-translational prenylation causes sustained activation of RAC, Cdc42 and Rho GTPases', Bone, vol. 38, pp. 45 - 45, http://dx.doi.org/10.1016/j.bone.2005.12.031
    Journal articles | 2006
    Professor Michael John Rogers
    Dunford JE; Kavanagh K; Oppermann U; Ebetino FH; Russell RGG; Rogers MJ, 2006, 'Investigations into the kinetic mechanism of inhibition of farnesyl diphosphate synthase by nitrogen containing bisphosphonates', Bone, vol. 38, pp. 47 - 48, http://dx.doi.org/10.1016/j.bone.2005.12.037
    Journal articles | 2006
    Professor Michael John Rogers
    Ebetino FH; Kashemirov B; McKenna CE; Evdokimov A; Pokross M; Barnett BL; Dunford J; Kavanagh K; Rogers MJ; Lundy MW; Oppermann U; Russell RGG, 2006, 'Molecular modeling comparison of nitrogen-containing bisphosphonates of varying potency co-crystalized in farnesyl diphosphate synthase', Bone, vol. 38, pp. 49 - 50, http://dx.doi.org/10.1016/j.bone.2005.12.042
    Journal articles | 2006
    Professor Michael John Rogers
    Coxon FP; Navea JR; Stewart CA; Thompson K; Roelofs A; Ebetino FH; McKenna CE; Kashemirov BA; Bala J; Rogers MJ, 2006, 'Target enzyme specificity, potency and potential lack of side-effects of novel phosphonocarboxylate analogues of bisphosphonates', Bone, vol. 38, pp. 46 - 47, http://dx.doi.org/10.1016/j.bone.2005.12.034
    Journal articles | 2006
    Professor Michael John Rogers
    Thompson K; Rogers MJ; Coxon FP; Crockett JC, 2006, 'Cytosolic entry of Bisphosphonates into macrophages and osteoclasts requires fluid-phase endocytosis and endosomal acidification', Bone, vol. 38, pp. 47 - 47, http://dx.doi.org/10.1016/j.bone.2005.12.035
    Journal articles | 2006
    Professor Michael John Rogers
    Coxon FP; Navea JR; Stewart CA; Al Jaber J; Ebetino FH; McKenna CE; Kashemirov BA; Mallard I; Rogers MJ, 2006, 'Structure-activity relationships of bisphosphonate analogues', Bone, vol. 38, pp. 46 - 46, http://dx.doi.org/10.1016/j.bone.2005.12.033
    Journal articles | 2006
    Professor Michael John Rogers
    Garrioch S; Roelofs AJ; Ebetino FH; Rogers MJ, 2006, 'Prevention of breast cancer cell adhesion to bone in vitro by bisphosphonates is mediated by their inhibitory effect on protein prenylation', Bone, vol. 38, pp. 59 - 60, http://dx.doi.org/10.1016/j.bone.2005.12.066
    Journal articles | 2006
    Professor Michael John Rogers
    Coxon FP; Thompson K; Ebetino FH; Rogers MJ, 2006, 'Resorbing osteoclasts increase the availability of mineral-bound bisphosphonates to non-resorbing cells', Bone, vol. 38, pp. 45 - 46, http://dx.doi.org/10.1016/j.bone.2005.12.032
    Journal articles | 2006
    Professor Michael John Rogers
    Thompson K; Kikuvi TM; Rogers MJ, 2006, 'Alkylamines prevent osteoclast formation and activity by inhibiting the mevalonate pathway', Bone, vol. 38, pp. 31 - 31, http://dx.doi.org/10.1016/j.bone.2006.01.124
    Journal articles | 2005
    Professor Michael John Rogers
    Coxon FP; Ebetino FH; Mules EH; Seabra MC; McKenna CE; Rogers MJ, 2005, 'Phosphonocarboxylate inhibitors of Rab geranylgeranyl transferase disrupt the prenylation and membrane localization of Rab proteins in osteoclasts in vitro and in vivo', Bone, vol. 37, pp. 349 - 358, http://dx.doi.org/10.1016/j.bone.2005.04.021
    Journal articles | 2005
    Professor Michael John Rogers
    Luckman SP; Hughes DE; Coxon FP; Russell GG; Rogers MJ, 2005, 'JBMR anniversary classic. Nitrogen-containing biophosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras. Originally published in Volume 7, number 4, pp 581-9 (1998).', Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, vol. 20, pp. 1265 - 1274, http://dx.doi.org/10.1359/jbmr.2005.20.7.1265
    Journal articles | 2005
    Professor Michael John Rogers
    Guenther A; Gordon S; Bakker F; Burger R; Tiemann M; Green JR; Rogers M; Gramatzki M, 2005, 'Zoledronate Exerts Direct Antiproliferative and Apoptotic Effects on Human Myeloma Cells In Vitro and In Vivo.', Blood, vol. 106, pp. 3387 - 3387, http://dx.doi.org/10.1182/blood.v106.11.3387.3387
    Journal articles | 2004
    Professor Michael John Rogers
    Thompson K; Rogers MJ, 2004, 'Statins Prevent Bisphosphonate-Induced γ,δ-T-Cell Proliferation and Activation in Vitro', Journal of Bone and Mineral Research, vol. 19, pp. 278 - 288, http://dx.doi.org/10.1359/JBMR.0301230
    Journal articles | 2004
    Professor Michael John Rogers
    Rogers MJ, 2004, 'From molds and macrophages to mevalonate: A decade of progress in understanding the molecular mode of action of bisphosphonates', Calcified Tissue International, vol. 75, pp. 451 - 461, http://dx.doi.org/10.1007/s00223-004-0024-1
    Journal articles | 2004
    Professor Michael John Rogers
    Guenther A; Gordon S; Bakker F; Burger R; Green JR; Rogers M; Gramatzki M, 2004, 'Zoledronic Acid Inhibits Protein Prenylation in Plasmacytoma Tumors In Vivo and Enhances Survival in the INA-6 SCID Mouse Model.', Blood, vol. 104, pp. 3360 - 3360, http://dx.doi.org/10.1182/blood.v104.11.3360.3360
    Journal articles | 2003
    Professor Michael John Rogers
    Mburu P; Mustapha M; Varela A; Weil D; El-Amraoui A; Holme RH; Rump A; Hardisty RE; Blanchard S; Coimbra RS; Perfettini I; Parkinson N; Mallon AM; Glenister P; Rogers MJ; Paige AJ; Moir L; Clay J; Rosenthal A; Liu XZ; Blanco G; Steel KP; Petit C; Brown SDM, 2003, 'Defects in whirlin, a PDZ domain molecule involved in stereocilia elongation, cause deafness in the whirler mouse and families with DFNB31', Nature Genetics, vol. 34, pp. 421 - 428, http://dx.doi.org/10.1038/ng1208
    Journal articles | 2003
    Professor Michael John Rogers
    Rogers MJ, 2003, 'New insights into the molecular mechanisms of action of bisphosphonates', Current Pharmaceutical Design, vol. 9, pp. 2643 - 2658, http://dx.doi.org/10.2174/1381612033453640
    Journal articles | 2003
    Professor Michael John Rogers
    Frith JC; Rogers MJ, 2003, 'Antagonistic effects of different classes of bisphosphonates in osteoclasts and macrophages in vitro', Journal of Bone and Mineral Research, vol. 18, pp. 204 - 212, http://dx.doi.org/10.1359/jbmr.2003.18.2.204
    Journal articles | 2003
    Professor Michael John Rogers
    Staal A; Frith JC; French MH; Swartz J; Güngör T; Harrity TW; Tamasi J; Rogers MJ; Feyen JHM, 2003, 'The ability of statins to inhibit bone resorption is directly related to their inhibitory effect on HMG-CoA reductase activity', Journal of Bone and Mineral Research, vol. 18, pp. 88 - 96, http://dx.doi.org/10.1359/jbmr.2003.18.1.88
    Journal articles | 2003
    Professor Michael John Rogers
    Coxon FP; Rogers MJ, 2003, 'The role of prenylated small GTP-binding proteins in the regulation of osteoclast function', Calcified Tissue International, vol. 72, pp. 80 - 84, http://dx.doi.org/10.1007/s00223-002-2017-2
    Journal articles | 2003
    Professor Michael John Rogers
    Coxon FP; Frith JC; Benford HL; Rogers MJ, 2003, 'Isolation and purification of rabbit osteoclasts.', Methods in molecular medicine, vol. 80, pp. 89 - 99, http://dx.doi.org/10.1385/1-59259-366-6:89
    Journal articles | 2002
    Professor Michael John Rogers
    Green JR; Rogers MJ, 2002, 'Pharmacologic profile of zoledronic acid: A highly potent inhibitor of bone resorption', Drug Development Research, vol. 55, pp. 210 - 224, http://dx.doi.org/10.1002/ddr.10071
    Journal articles | 2002
    Professor Michael John Rogers
    Thompson K; Dunford JE; Rogers MJ; Ebetino FH, 2002, 'Identification of a bisphosphonate that inhibits isopentenyl diphosphate isomerase and farnesyl diphosphate synthase', Biochemical and Biophysical Research Communications, vol. 290, pp. 869 - 873, http://dx.doi.org/10.1006/bbrc.2001.6289
    Journal articles | 2002
    Professor Michael John Rogers
    Gordon S; Helfrich MH; Sati HIA; Greaves M; Ralston SH; Culligan DJ; Soutar RL; Rogers MJ, 2002, 'Pamidronate causes apoptosis of plasma cells in vivo in patients with multiple myeloma', British Journal of Haematology, vol. 119, pp. 475 - 483, http://dx.doi.org/10.1046/j.1365-2141.2002.03824.x
    Journal articles | 2002
    Professor Michael John Rogers
    Lehenkari PP; Kellinsalmi M; Näpänkangas JP; Ylitalo KV; Mönkkönen J; Rogers MJ; Azhayev A; Kalervo Väänänen H; Hassinen IE, 2002, 'Further insight into mechanism of action of clodronate: Inhibition of mitochondrial ADP/ATP translocase by a nonhydrolyzable, adenine-containing metabolite', Molecular Pharmacology, vol. 61, pp. 1255 - 1262, http://dx.doi.org/10.1124/mol.61.5.1255
    Journal articles | 2002
    Professor Michael John Rogers
    Rogers MJ; Russell RG; Watts NB, 2002, 'Meeting report from what is new in bisphosphonates: Sixth workshop on bisphosphonates', BoneKEy-Osteovision, http://dx.doi.org/10.1138/2002041
    Journal articles | 2001
    Professor Michael John Rogers
    Benford HL; McGowan NWA; Helfrich MH; Nuttall ME; Rogers MJ, 2001, 'Visualization of bisphosphonate-induced caspase-3 activity in apoptotic osteoclasts in vitro', Bone, vol. 28, pp. 465 - 473, http://dx.doi.org/10.1016/S8756-3282(01)00412-4
    Journal articles | 2001
    Professor Michael John Rogers
    Suri S; Mönkkönen J; Taskinen M; Pesonen J; Blank MA; Phipps RJ; Rogers MJ, 2001, 'Nitrogen-containing bisphosphonates induce apoptosis of Caco-2 cells in vitro by inhibiting the mevalonate pathway: A model of bisphosphonate-induced gastrointestinal toxicity', Bone, vol. 29, pp. 336 - 343, http://dx.doi.org/10.1016/S8756-3282(01)00589-0
    Journal articles | 2001
    Professor Michael John Rogers
    Mönkkönen H; Rogers MJ; Makkonen N; Niva S; Auriola S; Mönkkönen J, 2001, 'The cellular uptake and metabolism of clodronate in RAW 264 macrophages', Pharmaceutical Research, vol. 18, pp. 1550 - 1555, http://dx.doi.org/10.1023/A:1013026313647
    Journal articles | 2001
    Professor Michael John Rogers
    Frith JC; Mönkkönen J; Auriola S; Mönkkönen H; Rogers MJ, 2001, 'The Molecular Mechanism of Action of the Antiresorptive and Antiinflammatory Drug Clodronate: Evidence for the Formation in Vivo of a Metabolite That Inhibits Bone Resorption and Causes Osteoclast and Macrophage Apoptosis', Arthritis and Rheumatism, vol. 44, pp. 2201 - 2210, http://dx.doi.org/10.1002/1529-0131(200109)44:9<2201::AID-ART374>3.0.CO;2-E
    Journal articles | 2001
    Professor Michael John Rogers
    Coxon FP; Helfrich MH; Larijani B; Muzylak M; Dunford JE; Marshall D; McKinnon AD; Nesbitt SA; Horton MA; Seabra MC; Ebetino FH; Rogers MJ, 2001, 'Identification of a Novel Phosphonocarboxylate Inhibitor of Rab Geranylgeranyl Transferase That Specifically Prevents Rab Prenylation in Osteoclasts and Macrophages', Journal of Biological Chemistry, vol. 276, pp. 48213 - 48222, http://dx.doi.org/10.1074/jbc.M106473200
    Journal articles | 2001
    Professor Michael John Rogers
    Dunford JE; Thompson K; Coxon FP; Luckman SP; Hahn FM; Poulter CD; Ebetino FH; Rogers MJ, 2001, 'Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates', Journal of Pharmacology and Experimental Therapeutics, vol. 296, pp. 235 - 242
    Journal articles | 2000
    Professor Michael John Rogers
    Coxon FP; Helfrich MH; Van't Hof R; Sebti S; Ralston SH; Hamilton A; Rogers MJ, 2000, 'Protein geranylgeranylation is required for osteoclast formation, function, and survival: Inhibition by bisphosphonates and GGTI-298', Journal of Bone and Mineral Research, vol. 15, pp. 1467 - 1476, http://dx.doi.org/10.1359/jbmr.2000.15.8.1467
    Journal articles | 2000
    Professor Michael John Rogers
    Shipman CM; Vanderkerken K; Rogers MJ; Lippitt JM; Asosingh K; Hughes DE; Van Camp B; Russell RGG; Croucher PI, 2000, 'The potent bisphosphonate ibandronate does not induce myeloma cell apoptosis in a murine model of established multiple myeloma', British Journal of Haematology, vol. 111, pp. 283 - 286, http://dx.doi.org/10.1046/j.1365-2141.2000.02310.x
    Journal articles | 2000
    Professor Michael John Rogers
    Mönkkönen H; Moilanen P; Mönkkönen J; Frith JC; Rogers MJ; Auriola S, 2000, 'Analysis of an adenine nucleotide-containing metabolite of clodronate using ion pair high-performance liquid chromatography-electrospray ionisation mass spectrometry', Journal of Chromatography B: Biomedical Sciences and Applications, vol. 738, pp. 395 - 403, http://dx.doi.org/10.1016/S0378-4347(99)00559-9
    Journal articles | 2000
    Professor Michael John Rogers
    Paige AJW; Kiernan BW; Varela A; Rogers MJC; Hughes D; Steel KP; Brown SDM, 2000, 'A deletion on chromosome 4 cosegregates with the whirler deafness mutation: Exclusion of Orm1 as a candidate', Mammalian Genome, vol. 11, pp. 51 - 57, http://dx.doi.org/10.1007/s003350010010
    Journal articles | 2000
    Professor Michael John Rogers
    Rogers MJ, 2000, 'Statins: Lower lipids and better bones?', Nature Medicine, vol. 6, pp. 21 - 23, http://dx.doi.org/10.1038/71484
    Journal articles | 1999
    Professor Michael John Rogers
    Fisher JE; Rogers MJ; Halasy JM; Luckman SP; Hughes DE; Masarachia PJ; Wesolowski G; Russell RGG; Rodan GA; Reszka AA, 1999, 'Alendronate mechanism of action: Geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro', Proceedings of the National Academy of Sciences of the United States of America, vol. 96, pp. 133 - 138, http://dx.doi.org/10.1073/pnas.96.1.133
    Journal articles | 1999
    Professor Michael John Rogers
    Rogers MJC; Fleming J; Kiernan BW; Mburu P; Varela A; Brown SDM; Steel KP, 1999, 'Genetic mapping of the whirler mutation', Mammalian Genome, vol. 10, pp. 513 - 519, http://dx.doi.org/10.1007/s003359901032
    Journal articles | 1999
    Professor Michael John Rogers
    Benford HL; Frith JC; Auriola S; Mönkkönen J; Rogers MJ, 1999, 'Farnesol and geranylgeraniol prevent activation of caspases by aminobisphosphonates: Biochemical evidence for two distinct pharmacological classes of bisphosphonate drugs', Molecular Pharmacology, vol. 56, pp. 131 - 140, http://dx.doi.org/10.1124/mol.56.1.131
    Journal articles | 1999
    Professor Michael John Rogers
    Rogers MJ; Frith JC; Luckman SP; Coxon FP; Benford HL; M̈onkk̈onen J; Auriola S; Chilton KM; Russell RGG, 1999, 'Molecular mechanisms of action of bisphosphonates', Bone, vol. 24, pp. 73S - 79S, http://dx.doi.org/10.1016/S8756-3282(99)00070-8
    Journal articles | 1999
    Professor Michael John Rogers
    Russell RGG; Rogers MJ, 1999, 'Bisphosphonates: From the laboratory to the clinic and back again', Bone, vol. 25, pp. 97 - 106, http://dx.doi.org/10.1016/S8756-3282(99)00116-7
    Journal articles | 1999
    Professor Michael John Rogers
    Makkonen N; Salminen A; Rogers MJ; Frith JC; Urtti A; Azhayeva E; Mönkkönen J, 1999, 'Contrasting effects of alendronate and clodronate on RAW 264 macrophages: The role of a bisphosphonate metabolite', European Journal of Pharmaceutical Sciences, vol. 8, pp. 109 - 118, http://dx.doi.org/10.1016/S0928-0987(98)00065-7
    Journal articles | 1999
    Professor Michael John Rogers
    Mönkkönen J; Makronen N; Rogers MJ; Frith JC; Auriola S, 1999, 'Effects of bisphosphonates on the inflammatory processes of activated macrophages', Phosphorus, Sulfur and Silicon and Related Elements, vol. 144-146, pp. 321 - 324, http://dx.doi.org/10.1080/10426509908546246
    Journal articles | 1998
    Professor Michael John Rogers
    Luckman SP; Hughes DE; Coxon FP; Russell RGG; Rogers MJ, 1998, 'Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras', Journal of Bone and Mineral Research, vol. 13, pp. 581 - 589, http://dx.doi.org/10.1359/jbmr.1998.13.4.581
    Journal articles | 1998
    Professor Michael John Rogers
    Luckman SP; Coxon FP; Ebetino FH; Russell RGG; Rogers MJ, 1998, 'Heterocycle-containing bisphosphonates cause apoptosis and inhibit bone resorption by preventing protein prenylation: Evidence from structure- activity relationships in J774 macrophages', Journal of Bone and Mineral Research, vol. 13, pp. 1668 - 1678, http://dx.doi.org/10.1359/jbmr.1998.13.11.1668
    Journal articles | 1998
    Professor Michael John Rogers
    Shipman CM; Croucher PI; Russell RGG; Helfrich MH; Rogers MJ, 1998, 'The bisphosphonate incadronate (YM175) causes apoptosis of human myeloma cells in vitro by inhibiting the mevalonate pathway', Cancer Research, vol. 58, pp. 5294 - 5297
    Journal articles | 1998
    Professor Michael John Rogers
    Mönkkönen J; Similä J; Rogers MJ, 1998, 'Effects of tiludronate and ibandronate on the secretion of proinflammatory cytokines and nitric oxide from macrophages in vitro', Life Sciences, vol. 62, http://dx.doi.org/10.1016/S0024-3205(97)01178-8
    Journal articles | 1998
    Professor Michael John Rogers
    Shipman CM; Rogers MJ; Apperley JF; Russell RGG; Croucher PI, 1998, 'Anti-tumour activity of bisphosphonates in human myeloma cells', Leukemia and Lymphoma, vol. 32, pp. 129 - 138, http://dx.doi.org/10.3109/10428199809059253
    Journal articles | 1998
    Professor Michael John Rogers
    Coxon FP; Benford HL; Russell RGG; Rogers MJ, 1998, 'Protein synthesis is required for caspase activation and induction of apoptosis by bisphosphonate drugs', Molecular Pharmacology, vol. 54, pp. 631 - 638
    Journal articles | 1998
    Professor Michael John Rogers
    Ebetino FH; Francis MD; Rogers MJ; Russell RGG, 1998, 'Mechanisms of action of etidronate and other bisphosphonates', Reviews in Contemporary Pharmacotherapy, vol. 9, pp. 233 - 243
    Journal articles | 1997
    Professor Michael John Rogers
    Rogers MJ; Xiong X; Ji X; Mönkkönen J; Russell RGG; Williamson MP; Ebetino FH; Watts DJ, 1997, 'Inhibition of growth of Dictyostelium discoideum amoebae by bisphosphonate drugs is dependent on cellular uptake', Pharmaceutical Research, vol. 14, pp. 625 - 630, http://dx.doi.org/10.1023/A:1012157212793
    Journal articles | 1997
    Professor Michael John Rogers
    Frith JC; Mönkkönen J; Blackburn GM; Russell RGG; Rogers MJ, 1997, 'Clodronate and liposome-encapsulated clodronate are metabolized to a toxic ATP analog, adenosine 5'-(β,γ-dichloromethylene) triphosphate, by mammalian cells in vitro', Journal of Bone and Mineral Research, vol. 12, pp. 1358 - 1367, http://dx.doi.org/10.1359/jbmr.1997.12.9.1358
    Journal articles | 1997
    Professor Michael John Rogers
    Auriola S; Frith J; Rogers MJ; Koivuniemi A; Mönkkönen J, 1997, 'Identification of adenine nucleotide-containing metabolites of bisphosphonate drugs using ion-pair liquid chromatography-electrospray mass spectrometry', Journal of Chromatography B: Biomedical Applications, vol. 704, pp. 187 - 195, http://dx.doi.org/10.1016/S0378-4347(97)00490-8
    Journal articles | 1997
    Professor Michael John Rogers
    Shipman CM; Rogers MJ; Apperley JF; Russell RGG; Croucher PI, 1997, 'Bisphosphonates induce apoptosis in human myeloma cell lines: A novel anti-tumour activity', British Journal of Haematology, vol. 98, pp. 665 - 672, http://dx.doi.org/10.1046/j.1365-2141.1997.2713086.x
    Journal articles | 1997
    Professor Michael John Rogers
    Russell RGG; Rogers MJ, 1997, 'Introduction to bisphosphonates and the clinical pharmacology of alendronate', British Journal of Rheumatology, vol. 36, pp. 10 - 14
    Journal articles | 1996
    Professor Michael John Rogers
    Rogers MJ; Brown RJ; Hodkin V; Blackburn GM; Russell RGG; Watts DJ, 1996, 'Bisphosphonates are incorporated into adenine nucleotides by human aminoacyl-tRNA synthetase enzymes', Biochemical and Biophysical Research Communications, vol. 224, pp. 863 - 869, http://dx.doi.org/10.1006/bbrc.1996.1113
    Journal articles | 1996
    Professor Michael John Rogers
    Rogers MJ; Chilton KM; Coxon FP; Lawry J; Smith MO; Suri S; Russell RGG, 1996, 'Bisphosphonates induce apoptosis in mouse macrophage-like cells in vitro by a nitric oxide-independent mechanism', Journal of Bone and Mineral Research, vol. 11, pp. 1482 - 1491, http://dx.doi.org/10.1002/jbmr.5650111015
    Journal articles | 1996
    Professor Michael John Rogers
    Frith JC; Graham R; Russell G; Michael Blackburn G; Watts DJ; Rogers MJ, 1996, 'The anti-resorptive drug clodronate is metabolised to a non-hydrolysable ATP analogue by mammalian cells in vitro', Biochemical Society Transactions, vol. 24, http://dx.doi.org/10.1042/bst024562s
    Journal articles | 1996
    Professor Michael John Rogers
    Rogers MJ; Chilton KM; Luckman SP; Russell RGG; Coxon FP, 1996, 'MOLECULAR STUDIES OF APOPTOSIS INDUCED BY ANTI-RESORPTIVE BISPHOSPHONATE DRUGS', Biochemical Society Transactions, vol. 24, pp. 568S - 568S, http://dx.doi.org/10.1042/bst024568sc
    Journal articles | 1995
    Professor Michael John Rogers
    Rogers MJ; Xiong X; Brown RJ; Watts DJ; Russell RGG; Bayless AV; Ebetino FH, 1995, 'Structure-activity relationships of new heterocycle-containing bisphosphonates as inhibitors of bone resorption and as inhibitors of growth of Dictyostelium discoideum amoebae', Molecular Pharmacology, vol. 47, pp. 398 - 402
    Journal articles | 1995
    Professor Michael John Rogers
    Rogers MJ; Chilton KM; Suri S; Russell RGG, 1995, 'Bisphosphonates induce apoptosis in mouse macrophage-like cells by a mechanism that does not involve changes in the level of nitric oxide or p53', Bone, vol. 17, pp. 605 - 605, http://dx.doi.org/10.1016/8756-3282(96)87972-5
    Journal articles | 1994
    Professor Michael John Rogers
    Fleming J; Rogers MJC; Brown SDM; Steel KP, 1994, 'Linkage analysis of the whirler deafness gene on mouse chromosome 4', Genomics, vol. 21, pp. 42 - 48, http://dx.doi.org/10.1006/geno.1994.1222
    Journal articles | 1994
    Professor Michael John Rogers
    Rogers MJ; Watts DJ; Russell RGG; Ji X; Xiong X; Blackburn GM; Bayless AV; Ebetino FH, 1994, 'Inhibitory effects of bisphosphonates on growth of amoebae of the cellular slime mold dictyostelium discoideum', Journal of Bone and Mineral Research, vol. 9, pp. 1029 - 1039, http://dx.doi.org/10.1002/jbmr.5650090710
    Journal articles | 1994
    Professor Michael John Rogers
    Rogers MJ; Ji X; Russell GG; Blackburn GM; Williamson MP; Bayless AV; Ebetinos FH; Watts DJ, 1994, 'Incorporation of bisphosphonates into adenine nucleotides by amoebae of the cellular slime mould Dictyostelium discoideum', Biochemical Journal, vol. 303, pp. 303 - 311, http://dx.doi.org/10.1042/bj3030303
    Journal articles | 1994
    Professor Michael John Rogers
    Rogers MJ; Xiong X; Brown RJ; Watts DJ; Russell RGG; Ebetino FH, 1994, 'P71. The effects of bisphosphonates and their phosphinic acid analogues on bone resorption and on growth of Dictyostelium amoebae', Bone, vol. 15, pp. 247 - 247, http://dx.doi.org/10.1016/8756-3282(94)90804-4
    Journal articles | 1994
    Professor Michael John Rogers
    Brown RJ; Rogers MJ; Watts DJ; Russell RGG; Ebetino FH, 1994, 'P70. Inhibition by bisphosphonates of mammalian aminoacyl-tRNA synthetase enzymes', Bone, vol. 15, pp. 246 - 246, http://dx.doi.org/10.1016/8756-3282(94)90803-6
    Journal articles | 1994
    Professor Michael John Rogers
    Xiong X; Russell RGG; Rogers MJ; Ji X; Ebetino FH; Watts DJ, 1994, 'P69. Inhibition of growth of Dictyostelium discoideum by bisphosphonates is dependent on the bisphosphonates being taken up by pinocytosis', Bone, vol. 15, pp. 246 - 246, http://dx.doi.org/10.1016/8756-3282(94)90802-8
    Journal articles | 1992
    Professor Michael John Rogers
    Rogers M; Watts DJ; Ji X; Russell RGG; Xiong X; Blackburn GM; Ebetino FH, 1992, 'Inhibition by bisphosphonates of growth of a wild type and resistant strain of the slime mould dictyostelium discoideum', Bone and Mineral, vol. 17, pp. S16 - S16, http://dx.doi.org/10.1016/0169-6009(92)92277-w
    Journal articles | 1992
    Professor Michael John Rogers
    Rogers M; Watts DJ; Ji X; Russell RGG; Blackburn GM; Williamson MP; Ebetino FH, 1992, 'Metabolism of bisphosphonates by the slime mould dictyostelium discoideum', Bone and Mineral, vol. 17, pp. 187 - 187, http://dx.doi.org/10.1016/0169-6009(92)92084-4
    Journal articles | 1992
    Professor Michael John Rogers
    Rogers M; Watts DJ; Ji X; Russell RGG; Xiong X; Blackburn GM; Ebetino FH, 1992, 'Inhibition by bisphosphonates of growth of a wild type and resistant strain of the slime mould dictyostelium discoideum', Bone and Mineral, vol. 17, pp. 187 - 187, http://dx.doi.org/10.1016/0169-6009(92)92086-6
    Journal articles | 1992
    Professor Michael John Rogers
    Rogers M; Watts D; Ji X; Russell RGG; Blackburn GM; Ebetino FH, 1992, 'P2. Growth inhibitory effects of bisphosphonates on the slime mould dictyostelinm discoideum', Bone, vol. 13, pp. 275 - 276, http://dx.doi.org/10.1016/8756-3282(92)90221-h
    Journal articles | 1992
    Professor Michael John Rogers
    Rogers M; Watts DJ; Ji X; Russell RGG; Blackburn GM; Williamson MP; Ebetino FH, 1992, 'Metabolism of bisphosphonates by the slime mould dictyostelium discoideum', Bone and Mineral, vol. 17, pp. S16 - S16, http://dx.doi.org/10.1016/0169-6009(92)92275-u
    Journal articles | 1992
    Professor Michael John Rogers
    Rogers MJ; Russell RGG; Blackburn GM; Williamson MP; Watts DJ, 1992, 'Metabolism of halogenated bisphosphonates by the cellular slime mould dictyostelium discoideum', Biochemical and Biophysical Research Communications, vol. 189, pp. 414 - 423, http://dx.doi.org/10.1016/0006-291X(92)91574-A
    Journal articles | 1991
    Professor Michael John Rogers
    Blackburn GM; Ashton PR; Guo M; Rogers M; Taylor G; Guranowski A; Watts D, 1991, 'Application of phosphonate and thiophosphate analogues of nucleotides to studies of some enzyme reactions', Heteroatom Chemistry, vol. 2, pp. 163 - 170, http://dx.doi.org/10.1002/hc.520020118
    Journal articles | 1990
    Professor Michael John Rogers
    Rogers MJ; Donovan DT; Rogers MH, 1990, 'A deductive enquiry system for a palaeontological database of museum material', Palaeontology, vol. 33, pp. 613 - 622
    Journal articles | 1985
    Professor Michael John Rogers
    Rogers MJ, 1985, 'Non-marine pelecypods from the Riversdale Group (Upper Carboniferous), Nova Scotia.', 9e congres international de stratigraphie et de geologie du Carbonifere, Washington et Champaign-Urbana, 1979. Compte rendu. Vol. 5, pp. 261 - 270
  • Conference Papers | 2019
    Professor Michael John Rogers
    McDonald M; Khoo WH; Mohanty S; Terry R; Chai R; Quinn J; Pettitt J; Xiao Y; Baldock P; Rogers M; Croucher P; Phan T; Ng PY; Pavlos N; Biro M, 2019, 'Intravital imaging of osteoclasts in vivo reveals novel osteoclast fate which may underlie the therapeutic response to Denosumab withdrawal', in JOURNAL OF BONE AND MINERAL RESEARCH, WILEY, Orlando, FL, pp. 44 - 45, presented at Annual Meeting of the American-Society-for-Bone-and Mineral Research, Orlando, FL, 20 September 2019 - 23 September 2019, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000508356600130&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2019
    Professor Michael John Rogers
    McDonald M; Khoo WH; Mohanty S; Terry R; Chai R; Quinn J; Pettitt J; Xiao Y; Baldock P; Rogers M; Croucher P; Tri P; Ng PY; Pavlos N; Biro M, 2019, 'Intravital imaging of osteoclasts in vivo reveals novel osteoclast fate which may underlie the therapeutic response to Denosumab withdrawal', in JOURNAL OF BONE AND MINERAL RESEARCH, WILEY, Orlando, FL, Vol. 34, pp. 44 - 45, presented at Annual Meeting of the American-Society-for-Bone-and Mineral Research, Orlando, FL, 20 September 2019 - 23 September 2019, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000508614700130&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2017
    Professor Michael John Rogers
    McDonald M; Ng PY; Butt D; Pathmanandavel K; Biro M; Terry R; Khoo WH; Mohanty S; Simic M; Chai R; Quinn J; Pettitt J; Abi-Hanna D; Jain R; Weninger W; Baldock P; Rogers M; Brink R; Pavlos N; Croucher P; Phan T, 2017, 'Intravital imaging of osteoclasts in vivo reveals cellular recycling as a novel cell fate mechanism.', in JOURNAL OF BONE AND MINERAL RESEARCH, WILEY, Denver, CO, Vol. 32, pp. S37 - S37, presented at Annual Meeting of the American-Society-for-Bone-and-Mineral-Research (ASBMR), Denver, CO, 08 September 2017 - 11 September 2017, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000418869200110&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2016
    Professor Michael John Rogers
    McDonald M; Butt D; Terry R; Quinn J; Rogers M; Brink R; Croucher P; Phan T, 2016, 'Real-time intravital longitudinal imaging of osteoclast formation, function and fate during bone remodeling', in EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY-BLACKWELL, Melbourne, AUSTRALIA, Vol. 46, pp. 270 - 270, presented at International Congress of Immunology (ICI), Melbourne, AUSTRALIA, 21 August 2016 - 26 August 2016, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000383610400545&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2016
    Professor Michael John Rogers
    Byrne NM; Khoo WH; Mourad N; Quinn JAPJ; Shah S; Mcdonald MM; Cazet A; Swarbrick A; Phan TG; Rogers MJ; Croucher PI, 2016, 'Identification of dormant prostate cancer cells in the skeleton in vivo and ex vivo', in BJU INTERNATIONAL, WILEY-BLACKWELL, Melbourne, AUSTRALIA, Vol. 118, pp. 35 - 36, presented at 17th Asia-Pacific Prostate Cancer Conference, Melbourne, AUSTRALIA, 31 August 2016 - 03 September 2016, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000381708200082&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2016
    Professor Michael John Rogers
    Munoz MA; Junankar S; Jurczyluk J; Preston A; Zlatev H; Auriola S; Rogers M, 2016, 'Understanding the anti-tumour potential of bisphosphonate drugs: inhibitory effects on macrophage populations outside the skeleton', in EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY-BLACKWELL, Melbourne, AUSTRALIA, Vol. 46, pp. 836 - 836, presented at International Congress of Immunology (ICI), Melbourne, AUSTRALIA, 21 August 2016 - 26 August 2016, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000383610402071&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2015
    Professor Michael John Rogers
    Rogers M, 2015, 'Bisphosphonates and cancer: seeing old drugs in a new light', in CLINICAL ENDOCRINOLOGY, WILEY, Adelaide, AUSTRALIA, Vol. 84, pp. 3 - 3, presented at Annual Scientific Meeting of the Endocrine-Society-of-Australia, Adelaide, AUSTRALIA, 23 August 2015 - 26 August 2015, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000372310400008&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2014
    Professor Michael John Rogers
    Rogers MJ; Junankar S; McKenna CE; Sun S; Tri GP, 2014, 'Intravital 2-photon imaging reveals tumour-associated macrophages as the cellular targets underlying the anti-tumour activity of bisphosphonates in vivo.', in JOURNAL OF BONE AND MINERAL RESEARCH, WILEY-BLACKWELL, Houston, TX, pp. S14 - S14, presented at Annual Meeting of the American-Society-for-Bone-and-Mineral-Research, Houston, TX, 12 September 2014 - 15 September 2014, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000356598700039&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2012
    Professor Michael John Rogers
    Wuerger T; Roschger P; Zwettler E; Fratzl P; Rogers MJ; Klaushofer K; Rumpler M, 2012, 'Osteoclasts on bone and dentin in vitro: Mechanism of degradation and comparison of resorption behaviour', in BONE, ELSEVIER SCIENCE INC, Vienna, AUSTRIA, pp. S9 - S9, presented at International Conference on Progress in Bone and Mineral Research / Annual Autumn Conference of the Austrian-Society-for-Bone-and-Mineral-Research including a Symposium on Calcium Sensing Receptor, Vienna, AUSTRIA, 29 November 2012 - 01 December 2012, http://dx.doi.org/10.1016/j.bone.2012.08.023
    Conference Papers | 2011
    Professor Michael John Rogers
    Sun S; Blazewska KM; Kashemirov BA; Roelofs AJ; Coxon FP; Rogers MJ; Ebetino FH; Mckenna MJ; Mckenna CE, 2011, 'Synthesis and characterization of novel fluorescent nitrogen-containing bisphosphonate imaging probes for bone active drugs', in Phosphorus, Sulfur and Silicon and the Related Elements, pp. 970 - 971, http://dx.doi.org/10.1080/10426507.2010.526674
    Conference Papers | 2011
    Professor Michael John Rogers
    Shay G; Hornick M; Heys S; Weilbaecher K; Rogers M, 2011, 'Abstract LB-159: Bisphosphonates are internalised by myeloid derived suppressor cells (MDSCs) in vivo in a mouse model of breast cancer', in Immunology, American Association for Cancer Research, presented at Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL, http://dx.doi.org/10.1158/1538-7445.am2011-lb-159
    Conference Papers | 2010
    Professor Michael John Rogers
    Thompson K; Roelofs AJ; Jauhiainen M; Mönkkönen H; Mönkkönen J; Rogers MJ, 2010, 'Activation of γΔ T cells by bisphosphonates', in Advances in Experimental Medicine and Biology, pp. 11 - 20, http://dx.doi.org/10.1007/978-1-4419-1050-9_2
    Conference Papers | 2007
    Professor Michael John Rogers
    Russell RGG; Xia Z; Dunford JE; Oppermann U; Kwaasi A; Hulley PA; Kavanagh KL; Triffitt JT; Lundy MW; Phipps RJ; Barnett BL; Coxon FP; Rogers MJ; Watts NB; Ebetino FH, 2007, 'Bisphosphonates: An update on mechanisms of action and how these relate to clinical efficacy', in Annals of the New York Academy of Sciences, pp. 209 - 257, http://dx.doi.org/10.1196/annals.1402.089
    Conference Papers | 2006
    Professor Michael John Rogers
    Lipton A; Berenson JR; Body JJ; Boyce BF; Bruland OS; Carducci MA; Cleeland CS; Clohisy DR; Coleman RE; Cook RJ; Guise TA; Pearse RN; Powles TJ; Rogers MJ; Roodman GD; Smith MR; Suva LJ; Vessella RL; Weilbaecher KN; King L, 2006, 'Advances in treating metastatic bone cancer: Summary statement for the First Cambridge Conference', in Clinical Cancer Research, http://dx.doi.org/10.1158/1078-0432.CCR-06-1213
    Conference Papers | 2006
    Professor Michael John Rogers
    Thompson K; Rogers MJ, 2006, 'Alkylamines and bisphosphonates: A common mechanism for activation of γδ T-cells', in Haematologica Reports, pp. 1 - 3
    Conference Papers | 2006
    Professor Michael John Rogers
    Rogers MJ, 2006, 'New insights into the molecular actions of nitrogen-containing bisphosphonates', in Haematologica Reports, pp. 24 - 25
    Conference Papers | 2005
    Professor Michael John Rogers
    Ebetino FH; Rozé CN; McKenna CE; Barnett BL; Dunford JE; Russell RGG; Mieling GE; Rogers MJ, 2005, 'Molecular interactions of nitrogen-containing bisphosphonates within farnesyl diphosphate synthase', in Journal of Organometallic Chemistry, pp. 2679 - 2687, http://dx.doi.org/10.1016/j.jorganchem.2005.03.005
    Conference Papers | 2000
    Professor Michael John Rogers
    Rogers MJ; Gordon S; Benford HL; Coxon FP; Luckman SP; Monkkonen J; Frith JC, 2000, 'Cellular and molecular mechanisms of action of bisphosphonates', in Cancer, pp. 2961 - 2978, http://dx.doi.org/10.1002/1097-0142(20000615)88:12+<2961::aid-cncr12>3.0.co;2-l
    Conference Papers | 2000
    Professor Michael John Rogers
    Shipman CM; Rogers MJ; Vanderkerken K; Van Camp B; Russell RGG; Croucher PI, 2000, 'Bisphosphonates: Mechanisms of action in multiple myeloma', in Acta Oncologica, pp. 829 - 835, http://dx.doi.org/10.1080/028418600750063587
    Conference Papers | 1999
    Professor Michael John Rogers
    Russell RGG; Rogers MJ; Frith JC; Luckman SP; Coxon FP; Benford HL; Croucher PI; Shipman C; Fleisch HA, 1999, 'The pharmacology of bisphosphonates and new insights into their mechanisms of action', in Journal of Bone and Mineral Research, pp. 53 - 65, http://dx.doi.org/10.1002/jbmr.5650140212
    Conference Papers | 1999
    Professor Michael John Rogers
    Russell RGG; Croucher PI; Rogers MJ, 1999, 'Bisphosphonates: Pharmacology, mechanisms of action and clinical uses', in Osteoporosis International, http://dx.doi.org/10.1007/PL00004164
    Conference Papers | 1997
    Professor Michael John Rogers
    Kiernan BW; Fleming J; Rogers MJC; Self TJ; Varela A; Paige AJW; Brown SDM; Steel KP, 1997, 'Analysis of the deaf mouse mutant, whirler', in British Journal of Audiology, pp. 84 - 85
    Conference Papers | 1997
    Professor Michael John Rogers
    Rogers MJ; Watts DJ; Russell RGG, 1997, 'Overview of bisphosphonates', in Cancer, pp. 1652 - 1660, http://dx.doi.org/10.1002/(sici)1097-0142(19971015)80:8+<1652::aid-cncr15>3.0.co;2-z
    Conference Papers | 1996
    Professor Michael John Rogers
    Fleming J; Rogers MJC; Paige A; Varela A; Hughes DC; Ward M; Brown SDM; Steel KP, 1996, 'Progress in the identification of the whirler mutation', in British Journal of Audiology, pp. 139

Awards

Mike was first recipient of two prestigious international awards - the Iain T. Boyle Award (2003) from the European Calcified Tissue Society and the Herbert A. Fleisch Award (2009) from the International Bone & Mineral Society.

Grants

Current and recent grants:

St Vincent’s Clinic Foundation: $50,000. New approaches to understand and treat bowel inflammation in childhood autoinflammatory disease (Kavan Research Grant 2020) (CIA).

NHMRC: $715,755. 3 year project grant, 2018-2020. Protein prenylation and inflammation: new insights into the pathophysiology and treatment of mevalonate kinase deficiency (CIA).

NHMRC: $595,000. 3 year project grant, 2015-2018. How do bone-active drugs  increase patient survival? (CIA).

AIFA: $30,000. 1 year project grant, 2018. Restoring protein prenylation in a mouse model of mevalonate kinase deficiency (coapplicant with MA Munoz).

ARC: $395,000. 3 year project grant, 2017-2019. Navigating flux control through a fundamental, branched metabolic pathway (coapplicant with AJ Brown, UNSW).         

Marian & EH Flack Trust: $75,000. Curing a childhood inflammatory disease. 1-year pilot funding, 2017 (MJ Rogers, MA Munoz).

Ian Potter Foundation: $2,000. conference grant to support a 1-day symposium, Autoinflammatory Diseases: a workshop for researchers, clinicians and patients (June 2017).

Cancer Council NSW: $360,000. New uses for old drugs: anti-tumour actions of bisphosphonates. 3 year project grant, 2014-2016 (CIA).

PCFA/Movember: $5,000,000. 5-year Program Grant and Revolutionary Team Award, 2014-2017. Prostate Cancer Bone Metastasis (ProMis): New Opportunities for Therapeutic Development (coapplicant).

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