My research program is primarily directed at exploring and understanding the cell biology of human eye diseases in the context of normal human development and ageing. The challenge is to provide innovative approaches for human-tissue based ocular cell biology and the research program has evolved with changes in our understanding of disease pathogenesis, remaining uniquely human-tissue based.
Three main areas currently define my research program:
1. Understanding the microenvironment of primary ocular tumours, especially melanoma, and developing novel approaches for eye melanoma therapy. This includes studying normal human melanocytes (see image) (current PhD project).
2. Studying the normal ageing human retina and choroid, and age-related macular degeneration (AMD), the most common cause of blindness in those aged over 50 yrs.
3. Investigating the underlying pathogenesis of keratoconus (KC), a human corneal degeneration that is the major cause for corneal grafts.
We am currently funded for these research areas with grants from NH&MRC, Sydney Foundation for Medical Research (re-named National Foundation for Medical Research and Innovation in 2014) and the Ophthalmic Research Institute of Australia (ORIA), with well-established national and international collaborations in these areas.
2014 NH&MRC “The role of redox-related post - translational changes of complement factor H (CFH) in age-related macular degeneration” S Krilis, B Giannakopoulos, MC Madigan
2013 NH&MRC “Role of complement in retinal degeneration” K Volter, JM Provis, P Gatenby, MC Madigan
* involved in undergraduate courses VISN2111 Ocular Anatomy & Physiology (convenor), OPTM3231 Ocular Diseases and OPTM5251 Ocular Therapeutics and OPTM4291 Optometry, Medicine & Patient Management
* supervise students involved in MOptometry Coursework Research projects (OPTM7108 and 7308)
Clinical Associate Professor (Honorary), Discipline of Ophthalmology, Save Sight Institute, Sydney Medical School, University of Sydney
Visiting Fellow, John Curtin School of Medical Research, Australian National University
2013 Faculty of Science University of NSW Staff Excellence Award (Best Lecturer as voted by Students)