Conjoint Senior Lecturer

Dr Michelle Henderson

PhD

medicine-health
Sch Women's&Children's Health

Research Interests:
The major focus is on research projects directed at understanding the aggressive nature of childhood cancers such as neuroblastoma and leukaemia. These involve cellular and molecular biological experiments aimed at investigating the role of members of the multidrug transporter gene family in determining clinical outcome of the childhood cancer neuroblastoma and other malignancies. Other aspects include studies into the mechanism of relapse in acute lymphoblastic leukaemia and identification of novel therapeutics for infant leukaemia.

Phone
51570

Publications

  • Book Chapters | 2012
    Dr Michelle Henderson
    Fletcher JI; Haber M; Henderson M; Norris MD, 2012, 'Targeting Multidrug Resistance in Neuroblastoma', in Hayat MA (ed.), Pediatric Cancer Volume 1 Diagnosis, Therapy and Prognosis: Neuroblastoma, edn. Pediatric Cancer-Diagnosis Therapy and Prognosis, Springer, New York, USA, pp. 115 - 123, http://dx.doi.org/10.1007/978-94-007-2418-1_11
  • Journal articles | 2021
    Dr Michelle Henderson
    Xiao L; Somers K; Murray J; Pandher R; Karsa M; Ronca E; Bongers A; Terry R; Ehteda A; Gamble LD; Issaeva N; Leonova KI; O'Connor A; Mayoh C; Venkat P; Quek H; Brand J; Kusuma FK; Pettitt JA; Mosmann E; Kearns A; Eden G; Alfred S; Allan S; Zhai L; Kamili A; Gifford AJ; Carter DR; Henderson MJ; Fletcher JI; Marshall G; Johnstone RW; Cesare AJ; Ziegler DS; Gudkov AV; Gurova KV; Norris MD; Haber M, 2021, 'Dual Targeting of Chromatin Stability By The Curaxin CBL0137 and Histone Deacetylase Inhibitor Panobinostat Shows Significant Preclinical Efficacy in Neuroblastoma.', Clin Cancer Res, vol. 27, pp. 4338 - 4352, http://dx.doi.org/10.1158/1078-0432.CCR-20-2357
    Journal articles | 2021
    Dr Michelle Henderson
    Sutton R; Pozza LD; Khaw SL; Fraser C; Revesz T; Chamberlain J; Mitchell R; Trahair TN; Bateman CM; Venn NC; Law T; Ong E; Heatley SL; McClure BJ; Meyer C; Marschalek R; Henderson MJ; Cross S; White DL; Kotecha RS, 2021, 'Outcomes for Australian children with relapsed/refractory acute lymphoblastic leukaemia treated with blinatumomab', Pediatric Blood and Cancer, vol. 68, pp. e28922, http://dx.doi.org/10.1002/pbc.28922
    Journal articles | 2021
    Dr Michelle Henderson
    Karsa M; Kosciolek A; Bongers A; Mariana A; Failes T; Gifford AJ; Kees UR; Cheung LC; Kotecha RS; Arndt GM; Haber M; Norris MD; Sutton R; Lock RB; Henderson MJ; Somers K, 2021, 'Exploiting the reactive oxygen species imbalance in high-risk paediatric acute lymphoblastic leukaemia through auranofin', British Journal of Cancer, vol. 125, pp. 55 - 64, http://dx.doi.org/10.1038/s41416-021-01332-x
    Journal articles | 2021
    Dr Michelle Henderson
    Putra V; Hulme AJ; Tee AE; Sun JQJ; Atmadibrata B; Ho N; Chen J; Gao J; Norris MD; Haber M; Kavallaris M; Henderson MJ; McCarroll J; Trahair T; Liu T; Liu PY, 2021, 'The RNA-helicase DDX21 upregulates CEP55 expression and promotes neuroblastoma', Molecular Oncology, vol. 15, pp. 1162 - 1179, http://dx.doi.org/10.1002/1878-0261.12906
    Journal articles | 2021
    Dr Michelle Henderson
    Jessop S; Ruhayel S; Sutton R; Youlden DR; Pearson G; Lu C; Milne S; Henderson MJ; Aitken JF; Kotecha RS; Revesz T, 2021, 'Are outcomes for childhood leukaemia in Australia influenced by geographical remoteness and Indigenous race?', Pediatric Blood and Cancer, vol. 68, http://dx.doi.org/10.1002/pbc.28945
    Journal articles | 2021
    Dr Michelle Henderson
    Gamble LD; Purgato S; Henderson MJ; Di Giacomo S; Russell AJ; Pigini P; Murray J; Valli E; Milazzo G; Giorgi FM; Cowley M; Ashton LJ; Bhalshankar J; Schleiermacher G; Rihani A; Van Maerken T; Vandesompele J; Speleman F; Versteeg R; Koster J; Eggert A; Noguera R; Stallings RL; Tonini GP; Fong K; Vaksman Z; Diskin SJ; Maris JM; London WB; Marshall GM; Ziegler DS; Hogarty MD; Perini G; Norris MD; Haber M, 2021, 'A g316a polymorphism in the ornithine decarboxylase gene promoter modulates mycn‐driven childhood neuroblastoma', Cancers, vol. 13, http://dx.doi.org/10.3390/cancers13081807
    Journal articles | 2020
    Dr Michelle Henderson
    Korotchkina L; Kazyulkin D; Komarov PG; Polinsky A; Andrianova EL; Joshi S; Gupta M; Vujcic S; Kononov E; Toshkov I; Tian Y; Krasnov P; Chernov MV; Veith J; Antoch MP; Middlemiss S; Somers K; Lock RB; Norris MD; Henderson MJ; Haber M; Chernova OB; Gudkov AV, 2020, 'OT-82, a novel anticancer drug candidate that targets the strong dependence of hematological malignancies on NAD biosynthesis', Leukemia, vol. 34, pp. 1828 - 1839, http://dx.doi.org/10.1038/s41375-019-0692-5
    Journal articles | 2020
    Dr Michelle Henderson
    Somers K; Evans K; Cheung L; Karsa M; Pritchard T; Kosciolek A; Bongers A; El-Ayoubi A; Forgham H; Middlemiss S; Mayoh C; Jones L; Gupta M; Kees UR; Chernova O; Korotchkina L; Gudkov AV; Erickson SW; Teicher B; Smith MA; Norris MD; Haber M; Lock RB; Henderson MJ, 2020, 'Effective targeting of NAMPT in patient-derived xenograft models of high-risk pediatric acute lymphoblastic leukemia', Leukemia, vol. 34, pp. 1524 - 1539, http://dx.doi.org/10.1038/s41375-019-0683-6
    Journal articles | 2020
    Dr Michelle Henderson
    Huynh T; Murray J; Flemming CL; Kamili A; Hofmann U; Cheung L; Roundhill EA; Yu DMT; Webber HT; Schwab M; Henderson MJ; Haber M; Norris MD; Fletcher JI, 2020, 'CCI52 sensitizes tumors to 6-mercaptopurine and inhibits MYCN-amplified tumor growth', Biochemical Pharmacology, vol. 172, http://dx.doi.org/10.1016/j.bcp.2019.113770
    Journal articles | 2020
    Dr Michelle Henderson
    Millstein J; Budden T; Goode EL; Anglesio MS; Talhouk A; Intermaggio MP; Leong HS; Chen S; Elatre W; Gilks B; Nazeran T; Volchek M; Bentley RC; Wang C; Chiu DS; Kommoss S; Leung SCY; Senz J; Lum A; Chow V; Sudderuddin H; Mackenzie R; George J; Bowtell D; Chenevix-Trench G; Green A; Webb P; deFazio A; Gertig D; Traficante N; Fereday S; Moore S; Hung J; Harrap K; Sadkowsky T; Pandeya N; Malt M; Mellon A; Robertson R; Vanden Bergh T; Jones M; Mackenzie P; Maidens J; Nattress K; Chiew YE; Stenlake A; Sullivan H; Alexander B; Ashover P; Brown S; Corrish T; Green L; Jackman L; Ferguson K; Martin K; Martyn A; Ranieri B; White J; Jayde V; Mamers P; Bowes L; Galletta L; Giles D; Hendley J; Alsop K; Schmidt T; Shirley H; Ball C; Young C; Viduka S; Tran H; Bilic S; Glavinas L; Brooks J; Stuart-Harris R; Kirsten F; Rutovitz J; Clingan P; Glasgow A; Proietto A; Braye S; Otton G; Shannon J; Bonaventura T; Stewart J; Begbie S; Friedlander M; Bell D; Baron-Hay S; Ferrier,a A; Gard G; Nevell D; Pavlakis N; Valmadre S; Young B; Camaris C; Crouch R; Edwards L; Hacker N; Marsden D, 2020, 'Prognostic gene expression signature for high-grade serous ovarian cancer', Annals of Oncology, vol. 31, pp. 1240 - 1250, http://dx.doi.org/10.1016/j.annonc.2020.05.019
    Journal articles | 2020
    Dr Michelle Henderson
    Jung M; Gao J; Cheung L; Bongers A; Somers K; Clifton M; Ramsay EE; Russell AJ; Valli E; Gifford AJ; George J; Kennedy CJ; Wakefield MJ; Topp M; Ho GY; Scott CL; Bowtell DD; deFazio A; Norris MD; Haber M; Henderson MJ, 2020, 'ABCC4/MRP4 contributes to the aggressiveness of Myc-associated epithelial ovarian cancer', International Journal of Cancer, vol. 147, pp. 2225 - 2238, http://dx.doi.org/10.1002/ijc.33005
    Journal articles | 2020
    Dr Michelle Henderson
    Gao J; Jung MS; Mayoh C; Venkat P; Hannan KM; Fletcher JI; Kamili A; Gifford AJ; Kusnadi EP; Pearson RB; Hannan RD; Haber M; Norris MD; Somers K; Henderson MJ, 2020, 'Suppression of ABCE1-mediated mRNA translation limits N-MYC-driven cancer progression', Cancer Research, vol. 80, pp. 3706 - 3718, http://dx.doi.org/10.1158/0008-5472.CAN-19-3914
    Journal articles | 2020
    Dr Michelle Henderson
    Talhouk A; George J; Wang C; Budden T; Tan TZ; Chiu DS; Kommoss S; Leong HS; Chen S; Intermaggio MP; Gilks B; Nazeran TM; Volchek M; Elatre W; Bentley RC; Senz J; Lum A; Chow V; Sudderuddin H; Mackenzie R; Leong SCY; Liu G; Johnson D; Chen B; Alsop J; Banerjee SN; Behrens S; Bodelon C; Brand AH; Brinton L; Carney ME; Chiew YE; Cushing-Haugen KL; Cybulski C; Ennis D; Fereday S; Fortner RT; García-Donas J; Gentry-Maharaj A; Glasspool R; Goranova T; Greene CS; Haluska P; Harris HR; Hendley J; Hernandez BY; Herpel E; Jimenez-Linan M; Karpinskyj C; Kaufmann SH; Keeney GL; Kennedy CJ; Kobel M; Koziak JM; Larson MC; Lester J; Lewsley LA; Lissowska J; Lubiński J; Luk H; Macintyre G; Mahner S; McNeish IA; Menkiszak J; Nevins N; Osorio A; Oszurek O; Palacios J; Hinsley S; Pearce CL; Pike MC; Piskorz AM; Ray-Coquard I; Rhenius V; Rodriguez-Antona C; Sharma R; Sherman ME; de Silva D; Singh N; Sinn P; Slamon D; Song H; Steed H; Stronach EA; Thompson PJ; Tołoczko A; Trabert B; Traficante N; Tseng CC; Widschwendter M; Wilkens LR; Winham SJ; Winterhoff B; Beeghly-Fadiel A; Benitez J; Berchuck A; Brenton JD; Brown R; Chang-Claude J; Chenevix-Trench G, 2020, 'Development and validation of the gene expression predictor of high-grade serous ovarian carcinoma molecular SubTYPE (PrOTYPE)', Clinical Cancer Research, vol. 26, pp. 5411 - 5423, http://dx.doi.org/10.1158/1078-0432.CCR-20-0103
    Journal articles | 2019
    Dr Michelle Henderson
    Liu PY; Tee AE; Milazzo G; Hannan KM; Maag J; Mondal S; Atmadibrata B; Bartonicek N; Peng H; Ho N; Mayoh C; Ciaccio R; Sun Y; Henderson MJ; Gao J; Everaert C; Hulme AJ; Wong M; Lan Q; Cheung BB; Shi L; Wang JY; Simon T; Fischer M; Zhang XD; Marshall GM; Norris MD; Haber M; Vandesompele J; Li J; Mestdagh P; Hannan RD; Dinger ME; Perini G; Liu T, 2019, 'The long noncoding RNA lncNB1 promotes tumorigenesis by interacting with ribosomal protein RPL35', Nature Communications, vol. 10, pp. 5026, http://dx.doi.org/10.1038/s41467-019-12971-3
    Journal articles | 2019
    Dr Michelle Henderson
    Somers K; Kosciolek A; Bongers A; El-Ayoubi A; Karsa M; Mayoh C; Wadham C; Middlemiss S; Neznanov N; Kees UR; Lock RB; Gudkov A; Sutton R; Gurova K; Haber M; Norris MD; Henderson MJ, 2019, 'Potent antileukemic activity of curaxin CBL0137 against MLL-rearranged leukemia', International Journal of Cancer, http://dx.doi.org/10.1002/ijc.32582
    Journal articles | 2019
    Dr Michelle Henderson
    Somers K; Wen VW; Middlemiss SMC; Osborne B; Forgham H; Jung MS; Karsa M; Clifton M; Bongers A; Gao J; Mayoh C; Raoufi-Rad N; Kusnadi EP; Hannan KM; Scott DA; Kwek A; Liu B; Flemming C; Chudakova DA; Pandher R; Failes TW; Lim J; Angeli A; Osterman AL; Imamura T; Kees UR; Supuran CT; Pearson RB; Hannan RD; Davis TP; McCarroll J; Kavallaris M; Turner N; Gudkov AV; Haber M; Norris MD; Henderson MJ, 2019, 'A novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction', Oncogene, vol. 38, pp. 3824 - 3842, http://dx.doi.org/10.1038/s41388-018-0666-5
    Journal articles | 2018
    Dr Michelle Henderson
    Jung M; Russell A; Kennedy C; Gifford A, 2018, 'Clinical Importance of Myc Family Oncogene Aberrations in Epithelial Ovarian Cancer', JNCI: Cancer Spectrum, vol. 2, http://dx.doi.org/10.1093/jncics/pky047
    Journal articles | 2018
    Dr Michelle Henderson
    Somers K; Evans K; Cheung L; Korotchkina L; Chernova O; Gudkov A; Norris M; Haber M; Lock R; Henderson M, 2018, 'PO-028 Effective targeting of NAD+biosynthesis in patient-derived xenograft models of high-risk paediatric acute lymphoblastic leukaemia', ESMO Open, vol. 3, pp. A238 - A238, http://dx.doi.org/10.1136/esmoopen-2018-eacr25.563
    Journal articles | 2017
    Dr Michelle Henderson
    Jung MS; Russell AJ; Liu B; George J; Liu PY; Liu T; DeFazio A; Bowtell DDL; Oberthuer A; London WB; Fletcher JI; Haber M; Norris MD; Henderson MJ, 2017, 'A Myc activity signature predicts poor clinical outcomes in Myc-associated cancers', Cancer Research, vol. 77, pp. 971 - 981, http://dx.doi.org/10.1158/0008-5472.CAN-15-2906
    Journal articles | 2017
    Dr Michelle Henderson
    Murray J; Valli E; Yu DMT; Truong AM; Gifford AJ; Eden GL; Gamble LD; Hanssen KM; Flemming CL; Tan A; Tivnan A; Allan S; Saletta F; Cheung L; Ruhle M; Schuetz JD; Henderson MJ; Byrne JA; Norris MD; Haber M; Fletcher JI, 2017, 'Suppression of the ATP-binding cassette transporter ABCC4 impairs neuroblastoma tumour growth and sensitises to irinotecan in vivo', European Journal of Cancer, vol. 83, pp. 132 - 141, http://dx.doi.org/10.1016/j.ejca.2017.06.024
    Journal articles | 2016
    Dr Michelle Henderson
    Pasalic L; Williams R; Siupa A; Campbell H; Henderson MJ; Chen VMY, 2016, 'Enumeration of extracellular vesicles by a new improved flow cytometric method is comparable to fluorescence mode nanoparticle tracking analysis', Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 12, pp. 977 - 986, http://dx.doi.org/10.1016/j.nano.2015.12.370
    Journal articles | 2016
    Dr Michelle Henderson
    Fletcher JI; Williams RT; Henderson MJ; Norris MD; Haber M, 2016, 'ABC transporters as mediators of drug resistance and contributors to cancer cell biology', Drug Resistance Updates, vol. 26, pp. 1 - 9, http://dx.doi.org/10.1016/j.drup.2016.03.001
    Journal articles | 2016
    Dr Michelle Henderson
    French JD; Johnatty SE; Lu Y; Beesley J; Gao B; Kalimutho M; Henderson MJ; Russell AJ; Kar S; Chen X; Hillman KM; Kaufmann S; Sivakumaran H; O'Reilly M; Wang C; Korbie DJ; Lambrechts D; Despierre E; Van Nieuwenhuysen E; Lambrechts S; Vergote I; Karlan B; Lester J; Orsulic S; Walsh C; Fasching PA; Beckmann MW; Ekici AB; Hein A; Matsuo K; Hosono S; Pisterer J; Hillemanns P; Nakanishi T; Yatabe Y; Goodman MT; Lurie G; Matsuno RK; Thompson PJ; Pejovic T; Bean Y; Heitz F; Harter P; Du Bois A; Schwaab I; Hogdall E; Kjaer SK; Jensen A; Hogdall C; Lundvall L; Engelholm SA; Brown B; Flanagan JM; Metcalf MD; Siddiqui N; Sellers T; Fridley B; Cunningham J; Schildkraut JM; Iversen E; Weber RP; Brennan D; Berchuck A; Pharoah P; Harnett P; Norris MD; Haber M; Goode EL; Lee JS; Khanna KK; Meyer KB; Chenevix-Trench G; DeFazio A; Edwards SL; MacGregor S, 2016, 'Germline polymorphisms in an enhancer of PSIP1 are associated with progression-free survival in epithelial ovarian cancer', Oncotarget, vol. 7, pp. 6353 - 6368, http://dx.doi.org/10.18632/oncotarget.7047
    Journal articles | 2016
    Dr Michelle Henderson
    Somers K; Chudakova DA; Middlemiss SMC; Wen VW; Clifton M; Kwek A; Liu B; Mayoh C; Bongers A; Karsa M; Pan S; Cruikshank S; Scandlyn M; Hoang W; Imamura T; Kees UR; Gudkov AV; Chernova OB; Haber M; Norris MD; Henderson MJ, 2016, 'CCI-007, a novel small molecule with cytotoxic activity against infant leukemia with MLL rearrangements', Oncotarget, vol. 7, pp. 46067 - 46087, http://dx.doi.org/10.18632/oncotarget.10022
    Journal articles | 2015
    Dr Michelle Henderson
    Richmond J; Carol H; Evans K; High L; Mendomo A; Robbins A; Meyer C; Venn NC; Marschalek R; Henderson M; Sutton R; Kurmasheva RT; Kees UR; Houghton PJ; Smith MA; Lock RB, 2015, 'Effective targeting of the P53-MDM2 axis in preclinical models of infant MLL-rearranged acute lymphoblastic leukemia', Clinical Cancer Research, vol. 21, pp. 1395 - 1405, http://dx.doi.org/10.1158/1078-0432.CCR-14-2300
    Journal articles | 2014
    Dr Michelle Henderson
    Hedditch EL; Gao B; Russell AJ; Lu Y; Emmanuel C; Beesley J; Johnatty SE; Chen X; Harnett P; George J; Williams RT; Flemming C; Lambrechts D; Despierre E; Lambrechts S; Vergote I; Karlan B; Lester J; Orsulic S; Walsh C; Fasching P; Beckmann MW; Ekici AB; Hein A; Matsuo K; Hosono S; Nakanishi T; Yatabe Y; Pejovic T; Bean Y; Heitz F; Harter P; Du Bois A; Schwaab I; Hogdall E; Kjaer SK; Jensen A; Hogdall C; Lundvall L; Engelholm SA; Brown B; Flanagan J; Metcalf MD; Siddiqui N; Sellers T; Fridley B; Cunningham J; Schildkraut J; Iversen E; Weber RP; Berchuck A; Goode E; Bowtell DD; Chenevix-Trench G; Defazio A; Norris MD; Macgregor S; Haber M; Henderson MJ, 2014, 'ABCA transporter gene expression and poor outcome in epithelial ovarian cancer', Journal of the National Cancer Institute, vol. 106, http://dx.doi.org/10.1093/jnci/dju149
    Journal articles | 2014
    Dr Michelle Henderson
    Gao B; Russell A; Beesley J; Chen XQ; Healey S; Henderson M; Wong M; Emmanuel C; Galletta L; Johnatty SE; Bowtell D; Haber M; Norris M; Harnett P; Chenevix-Trench G; Balleine RL; Defazio A; Gertig D; Green A; Webb P; Hung J; Moore S; Traficante N; Fereday S; Harrap K; Sadkowsky T; Pandeya N; Stuart-Harris R; Kirsten F; Rutovitz J; Clingan P; Glasgow A; Proietto A; Braye S; Otton G; Shannon J; Bonaventura T; Stewart J; Begbie S; Friedlander M; Bell D; Baron-Hay S; Ferrier A; Gard G; Nevell D; Pavlakis N; Valmadre S; Young B; Camaris C; Crouch R; Edwards L; Hacker N; Marsden D; Robertson G; Beale P; Beith J; Carter J; Dalrymple C; Hamilton A; Houghton R; Russell P; Links M; Grygiel J; Hill J; Brand A; Byth K; Jaworski R; Sharma R; Achen A; Wain G; Ward B; Papadimos D; Crandon A; Cummings M; Horwood K; Obermair A; Perrin L; Wyld D; Nicklin J; Davy M; Oehler MK; Hall C; Dodd T; Healy T; Pittman K; Henderson D; Miller J; Pierdes J; Blomfield P; Challis D; McIntosh R; Parker A; Brown B; Rome R; Allen D; Grant P; Hyde S; Laurie R; Robbie M; Healy D, 2014, 'Paclitaxel sensitivity in relation to ABCB1 expression, efflux and single nucleotide polymorphisms in ovarian cancer', Scientific Reports, vol. 4, http://dx.doi.org/10.1038/srep04669
    Journal articles | 2014
    Dr Michelle Henderson
    Cheung L; Flemming CL; Watt F; Masada N; Yu DMT; Huynh T; Conseil G; Tivnan A; Polinsky A; Gudkov AV; Munoz MA; Vishvanath A; Cooper DMF; Henderson MJ; Cole SPC; Fletcher JI; Haber M; Norris MD, 2014, 'High-throughput screening identifies Ceefourin 1 and Ceefourin 2 as highly selective inhibitors of multidrug resistance protein 4 (MRP4)', Biochemical Pharmacology, vol. 91, pp. 97 - 108, http://dx.doi.org/10.1016/j.bcp.2014.05.023
    Journal articles | 2013
    Dr Michelle Henderson
    Johnatty SE; Beesley J; Gao B; Chen X; Lu Y; Law MH; Henderson MJ; Russell AJ; Hedditch EL; Emmanuel C; Fereday S; Webb PM; Goode EL; Vierkant RA; Fridley BL; Cunningham JM; Fasching PA; Beckmann MW; Ekici AB; Hogdall E; Kjaer SK; Jensen A; Hogdall C; Brown R; Paul J; Lambrechts S; Despierre E; Vergote I; Lester J; Karlan BY; Heitz F; Du Bois A; Harter P; Schwaab I; Bean Y; Pejovic T; Levine DA; Goodman MT; Camey ME; Thompson PJ; Lurie G; Shildkraut J; Berchuck A; Terry KL; Cramer DW; Norris MD; Haber M; MacGregor S; DeFazio A; Chenevix-Trench G, 2013, 'ABCB1 (MDR1) polymorphisms and ovarian cancer progression and survival: A comprehensive analysis from the Ovarian Cancer Association Consortium and the Cancer Genome Atlas', Gynecologic Oncology, vol. 131, pp. 8 - 14, http://dx.doi.org/10.1016/j.ygyno.2013.07.107
    Journal articles | 2012
    Dr Michelle Henderson
    Huynh T; Norris MD; Haber M; Henderson MJ, 2012, 'ABCC4/MRP4: a MYCN-regulated transporter and potential therapeutic target in neuroblastoma', FRONTIERS IN ONCOLOGY, vol. 2, http://dx.doi.org/10.3389/fonc.2012.00178
    Journal articles | 2012
    Dr Michelle Henderson
    Chenevix-Trench G; Lu Y; Johnatty S; Gamazon E; Beesley J; Chen X; Gao B; Harnett P; Stephanie Huang R; Despierre E; Heitz F; Hogdall E; Hogdall C; Brown R; Moyisch K; Fasching P; Goode E; Russell A; Henderson M; Haber M; Dolan E; Macgregor S; deFazio A, 2012, 'Identification of a genetic variant associated with treatment outcome in ovarian cancer: the potential role of cholesterol metabolism as a determinant of response to chemotherapy', Hereditary Cancer in Clinical Practice, vol. 10, pp. A36 - A36, http://dx.doi.org/10.1186/1897-4287-10-s2-a36
    Journal articles | 2010
    Dr Michelle Henderson
    Fletcher JI; Haber M; Henderson M; Norris MD, 2010, 'ABC transporters in cancer: more than just drug efflux pumps', Nature Reviews Cancer, vol. 10, pp. 147 - 156, http://dx.doi.org/10.1038/nrc2789
    Journal articles | 2010
    Dr Michelle Henderson
    Porro A; Haber M; Diolaiti D; Iraci N; Henderson M; Gherardi S; Valli E; Munoz M; Xue C; Flemming C; Schwab M; Wong JH; Marshall GM; Della valle G; Norris MD; Perini G, 2010, 'Direct and Coordinate Regulation of ATP-binding Cassette Transporter Genes by Myc Factors Generates Specific Transcription Signatures That Significantly Affect the Chemoresistance Phenotype of Cancer Cells', The Journal of Biological Chemistry, vol. 285, pp. 19532 - 19543, http://dx.doi.org/10.1074/jbc.M109.078584
    Journal articles | 2010
    Dr Michelle Henderson
    McDonald WJ; Sangster SM; Moffat LD; Henderson M; Too CKL, 2010, 'alpha 4 Phosphoprotein Interacts With EDD E3 Ubiquitin Ligase and Poly(A)-Binding Protein', Journal of Cellular Biochemistry, vol. 110, pp. 1123 - 1129, http://dx.doi.org/10.1002/jcb.22624
    Journal articles | 2010
    Dr Michelle Henderson
    Hu G; Wang XL; Saunders D; Henderson M; Russell AJ; Herring BP; Zhou J, 2010, 'Modulation of myocardin function by the ubiquitin E3 ligase UBR5', The Journal of Biological Chemistry, vol. 285, pp. 11800 - 11809, http://dx.doi.org/10.1074/jbc.M109.079384
    Journal articles | 2008
    Dr Michelle Henderson
    O Brien P; Davies M; Scurry JP; Smith A; Barton CA; Henderson M; Saunders DN; Gloss B; Patterson K; Clancy JL; Heinzelmann-Schwarz V; Scolyer R; Zeng Y; Williams E; Scurr LL; Defazio A; Quinn DI; Watts CK; Hacker NF; Henshall SM; Sutherland RL, 2008, 'The E3 ubiquitin ligase EDD is an adverse prognostic factor for serous epithelial ovarian cancer and modulates cisplatin resistance in vitro', British Journal of Cancer, vol. 98, pp. 1085 - 1093, http://dx.doi.org/10.1038/sj.bjc.6604281
    Journal articles | 2008
    Dr Michelle Henderson
    Henderson M; Choi S; Beesley A; Sutton R; Venn NC; Marshall GM; Kees UR; Haber M; Norris MD, 2008, 'Mechanism of relapse in pediatric acute lymphoblastic leukemia', Cell Cycle, vol. 7, pp. 1315 - 1320, http://dx.doi.org/10.4161/cc.7.10.5885
    Journal articles | 2008
    Dr Michelle Henderson
    Henderson M; Choi S; Beesley A; Baker DL; Wright DC; Papa R; Murch A; Campbell L; Lock RB; Norris MD; Haber M; Kees UR, 2008, 'A xenograft model of infant leukaemia reveals a complex MLL translocation', British Journal of Haematology, vol. 140, pp. 716 - 719, http://dx.doi.org/10.1111/j.1365-2141.2007.06966.x
    Journal articles | 2007
    Dr Michelle Henderson
    Munoz MA; Saunders DA; Henderson M; Clancy JL; Russell AJ; Lehrbach GM; Musgrove EA; Watts CK; Sutherland RL, 2007, 'The E3 Ubiquitin Ligase EDD Regulates S-Phase and G(2)/M DNA Damage Checkpoints', Cell Cycle, vol. 6 (24), pp. 3070 - 3077, http://dx.doi.org/10.4161/cc.6.24.5021
    Journal articles | 2007
    Dr Michelle Henderson
    Munoz MA; Henderson M; Haber M; Norris MD, 2007, 'Role of the MRP1/ABCC1 multidrug transporter protein in cancer', IUBMB Life, vol. 59, pp. 752 - 757, http://dx.doi.org/10.1080/15216540701736285
    Journal articles | 2007
    Dr Michelle Henderson
    Choi S; Henderson M; Kwan EN; Sutton R; Giles J; Venn NC; Marshall GM; Haber M; Norris MD; Giles J, 2007, 'Relapse in children with acute lymphoblastic leukaemia involving selection of a pre-existing drug resistant subclone', Blood, vol. 110, pp. 632 - 639, http://dx.doi.org/10.1182/blood-2007-01-067785
    Journal articles | 2007
    Dr Michelle Henderson
    Ohshima R; Ohta T; Wu W; Koike A; Iwatani T; Henderson M; Watts CK; Otsubo T, 2007, 'Putative tumor suppressor EDD interacts with and up-regulates APC', Genes To Cells, vol. 12, pp. 1339 - 1345, http://dx.doi.org/10.1111/j.1365-2443.2007.01138.x
    Journal articles | 2006
    Dr Michelle Henderson
    Henderson M; Munoz MA; Saunders DN; Clancy JL; Russell AJ; Williams B; Pappin D; Khanna KK; Jackson SP; Sutherland RL; Watts CK, 2006, 'EDD mediates DNA damage-induced activation of CHK2', The Journal of Biological Chemistry, vol. 281, pp. 39990 - 40000, http://dx.doi.org/10.1074/jbc.M602818200
    Journal articles | 2004
    Dr Michelle Henderson
    Saunders DN; Hird S; Withington SL; Dunwoodie SL; Henderson M; Biben C; Sutherland RL; Ormandy CJ; Watts CK, 2004, 'Edd, the murine hyperplastic disc gene, is essential for yolk sac vascularization and chorioallantoic fusion', Molecular and Cellular Biology, vol. 24, pp. 7225 - 7234, http://dx.doi.org/10.1128/MCB.24.16.7225-7234.2004
    Journal articles | 2003
    Dr Michelle Henderson
    Eblen ST; Kumar N; Shah K; Henderson M; Watts CK; Shokat KM; Weber MF, 2003, 'Identification of novel ERK2 substrates through use of an engineered kinase and ATP analogs', The Journal of Biological Chemistry, vol. 278, pp. 14926 - 14935, http://dx.doi.org/10.1074/jbc.M300485200
    Journal articles | 2003
    Dr Michelle Henderson
    Clancy JL; Henderson M; Russell AJ; Anderson D; Bova RJ; Campbell IG; Choong DH; Macdonald GAM; Mann GJ; Nolan T; Brady G; Olopade OI; Woollatt E; Davies MJ; Segara D; Hacker NF; Henshall SM; Sutherland RL; Watts CK, 2003, 'Edd, the human orthologue of the hyperplastic discs tumour supressor gene, is amplified and overexpressed in cancer', Oncogene, vol. 22, pp. 5070 - 5081, http://dx.doi.org/10.1038/sj.onc.1206775
    Journal articles | 2002
    Dr Michelle Henderson
    Beh KJ; Hulme DJ; Callaghan MJ; Leish Z; Lenane I; Windon RG; Maddox JF, 2002, 'A genome scan for quantitative trait loci affecting resistance to Trichostrongylus colubriformis in sheep', Animal Genetics, vol. 33, pp. 97 - 106, http://dx.doi.org/10.1046/j.1365-2052.2002.00829.x
    Journal articles | 2002
    Dr Michelle Henderson
    Henderson MJ; Russell AJ; Hird S; Muñoz M; Clancy JL; Lehrbach GM; Calanni ST; Jans DA; Sutherland RL; Watts CKW, 2002, 'EDD, the human hyperplastic discs protein, has a role in progesterone receptor coactivation and potential involvement in DNA damage response', Journal of Biological Chemistry, vol. 277, pp. 26468 - 26478, http://dx.doi.org/10.1074/jbc.M203527200
    Journal articles | 2001
    Dr Michelle Henderson
    Beh KJ; Callaghan MJ; Leish Z; Hulme DJ; Lenane I; Maddox JF, 2001, 'A genome scan for QTL affecting fleece and wool traits in Merino sheep', Wool Technology and Sheep Breeding, vol. 49, pp. 88 - 97
    Journal articles | 1998
    Dr Michelle Henderson
    Callaghan M; Russel AJ; Woollatt E; Sutherland GR; Sutherland RL; Watts CK, 1998, 'Identification of a human HECT family protein with homology to the Drosophila tumor suppressor gene hyperplastic discs', Oncogene, vol. 17, pp. 3479 - 3491, http://dx.doi.org/10.1038/sj.onc.1202249
    Journal articles | 1997
    Dr Michelle Henderson
    Hamilton JA; Callaghan M; Sutherland RL; Watts CG, 1997, 'Identification of PRG1, a novel progestin-responsive gene with sequence homology to 6-phosphofructo-2-kinase/fuctose-2, 6-Bisphosphatase', Molecular Endocrinology, vol. 11, pp. 490 - 502, http://dx.doi.org/10.1210/mend.11.4.9909
    Journal articles | 1996
    Dr Michelle Henderson
    Callaghan MJ; Beh KJ, 1996, 'A tandemly repetitive DNA sequence is present at diverse locations in the genome of Ostertagia circumcincta', Gene, vol. 174, pp. 273 - 279, http://dx.doi.org/10.1016/0378-1119(96)00093-5
    Journal articles | 1994
    Dr Michelle Henderson
    Callaghan MJ; Beh KJ, 1994, 'A Middle-Repetitive DNA Sequence Element in the Sheep Parasitic Nematode, Trichostrongylus Colubriformis', Parasitology, vol. 109, pp. 345 - 350, http://dx.doi.org/10.1017/S0031182000078379
    Journal articles | 1994
    Dr Michelle Henderson
    Callaghan MJ; Beh KJ, 1994, 'Characterization of a tandemly repetitive DNA sequence from Haemonchus contortus', International Journal for Parasitology, vol. 24, pp. 137 - 141, http://dx.doi.org/10.1016/0020-7519(94)90068-X
    Journal articles | 1991
    Dr Michelle Henderson
    Champion A; Gooley AA; Callaghan M; Carrin MI; Bernstein RL; Smith Williams EKL, 1991, 'Immunodominant carbohydrate determinants in the multicellular stages of Dictyostelium discoideum', Journal of General Microbiology, vol. 137, pp. 2431 - 2438, http://dx.doi.org/10.1099/00221287-137-10-2431
    Journal articles | 1991
    Dr Michelle Henderson
    Sleasman JW; Henderson M; Barrett DJ, 1991, 'Con A-induced suppressor cell function depends on the activation of the CD4+CD45RA inducer T cell subpopulation', Cellular Immunology, vol. 133, pp. 367 - 378, http://dx.doi.org/10.1016/0008-8749(91)90111-N
  • Conference Abstracts | 2019
    Dr Michelle Henderson
    Haber M; Gamble L; Xiao L; Pandher R; Somers K; Murray J; Khan A; Yu D; Franshaw L; Burns MR; Tsoli M; Ehteda A; Cesare A; O'Connor A; Mussai F; de Santo C; Cheng P; Korotchkina L; Gurova K; Tyrrell V; Mould E; Lau L; Dong AKQ; Mayoh C; Arndt G; Barahona P; Failes T; Fletcher J; Fuentes-Bolanos N; Gauthier M-E; Gifford A; Grebert-Wade D; Kamili A; Kumar A; Nagabushan S; O'Brien T; Strong P; Sherstyuk A; Thomas D; Trahair T; Tucker K; Warby M; Wong M; Xie J; Evans K; Lock R; Chernova OB; Henderson M; Gudkov AV; Ekert P; Cowley MJ; Marshall GM; Ziegler DS; Norris MD, 2019, 'Molecular targeted therapies and precision medicine for children with neuroblastoma and other refractory malignancies', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, Montreal, CANADA, Vol. 80, pp. 23 - 24, presented at AACR Special Conference on the Advances in Pediatric Cancer Research, Montreal, CANADA, 17 September 2019 - 20 September 2019, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000551367400013&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2018
    Dr Michelle Henderson
    Millstein J; Budden T; Anglesio M; Talhouk A; Beeghly-Fadiel A; Berchuck A; Chenevix-Trench G; deFazio A; Fasching PA; Gayther S; Garcia M; Goode EL; Henderson M; Konecny GE; Orsulic S; Huntsman D; Bowtell D; Doherty J; Pharoah P; Ramus SJ, 2018, 'A gene expression prognostic signature for overall survival in patients with high-grade serous ovarian cancer.', in JOURNAL OF CLINICAL ONCOLOGY, AMER SOC CLINICAL ONCOLOGY, Vol. 36, http://dx.doi.org/10.1200/JCO.2018.36.15_suppl.5583
    Conference Posters | 2018
    Dr Michelle Henderson
    Karsa M; Failes T; Arndt GM; Kees UR; Haber M; Norris MD; Sutton R; Lock RB; Somers K; Henderson MJ, 2018, 'PO-405 Repositioning existing drugs as novel therapeutics for high-risk paediatric leukaemia', Vol. 3, pp. A181 - A181, http://dx.doi.org/10.1136/esmoopen-2018-eacr25.431
    Conference Papers | 2017
    Dr Michelle Henderson
    Evans K; Pritchard T; Henderson MJ; Somers K; Karsa M; Cheung L; Yung R; Erickson SW; Korotchkina L; Chernova O; Gudkov A; Smith MA; Lock RB, 2017, 'Abstract 1942: The nicotinamide phosphoribosyltransferase (NAMPT) inhibitor, OT-82, exhibitsin vitroandin vivoefficacy against patient-derived xenograft models of high-risk acute lymphoblastic leukemia', in Tumor Biology, American Association for Cancer Research, presented at Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC, http://dx.doi.org/10.1158/1538-7445.am2017-1942
    Conference Papers | 2017
    Dr Michelle Henderson
    Gao J; Somers K; Hannan KM; Fletcher JI; Liu B; Hannan RD; Pearson RB; Haber M; Norris MD; Henderson MJ, 2017, 'Abstract 1956: ABCE1 regulates the translational profile of neuroblastoma to drive tumor progression', in Tumor Biology, American Association for Cancer Research, presented at Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC, http://dx.doi.org/10.1158/1538-7445.am2017-1956
    Conference Papers | 2017
    Dr Michelle Henderson
    Somers K; Middlemiss S; Biktasova A; Karsa M; Cheung L; Kosciolek A; Evans K; Mayoh C; Kees UR; Korotchkina L; Chernova OB; Lock RB; Gudkov AV; Haber M; Norris MD; Henderson MJ, 2017, 'Inhibition of NAMPT as a novel therapeutic strategy for infant leukemia', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, Washington, DC, presented at Annual Meeting of the American-Association-for-Cancer-Research (AACR), Washington, DC, 01 April 2017 - 05 April 2017, http://dx.doi.org/10.1158/1538-7445.AM2017-1175
    Conference Papers | 2015
    Dr Michelle Henderson
    Williams R; Russell A; Bongers A; Sagnella S; Fife C; Jessup W; DeFazio A; Chenevix-Trench G; Haber M; Norris M; Henderson M, 2015, 'Abstract 313: Examining the role of ABCA1 cholesterol transporter in ovarian cancer spheroids', in Tumor Biology, American Association for Cancer Research, presented at Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA, http://dx.doi.org/10.1158/1538-7445.am2015-313
    Conference Abstracts | 2015
    Dr Michelle Henderson
    Haber M; Murray J; Gamble L; Carnegie-Clark A; Webber H; Ruhle M; Henderson MJ; Middlemass S; Carter D; Tsoli M; Ehteda A; Simon S; Oberthuer A; Fischer M; Gurova K; Burkhart C; Purmal A; Lock RB; Ziegler D; Marshall GM; Gudkov AV; Norris MD, 2015, 'The FACT histone chaperone complex is highly expressed in aggressive drug refractory childhood cancers and the anti-FACT compound CBL0137 represents a highly promising therapeutic approach in this setting', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, Philadelphia, PA, Vol. 75, presented at 106th Annual Meeting of the American-Association-for-Cancer-Research (AACR), Philadelphia, PA, 18 April 2015 - 22 April 2015, http://dx.doi.org/10.1158/1538-7445.AM2015-1611
    Conference Papers | 2012
    Dr Michelle Henderson
    Huynh T; Tivnan A; Munoz M; Cheung L; Vishvanath A; Flemming C; Watt F; Burkhart C; Gudkov A; Fletcher J; Henderson M; Norris M; Haber M, 2012, 'Abstract 1834: Targeting ABC transporters in cancer through small molecule inhibitors', in Experimental and Molecular Therapeutics, American Association for Cancer Research, presented at Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL, http://dx.doi.org/10.1158/1538-7445.am2012-1834
    Conference Papers | 2011
    Dr Michelle Henderson
    Norris MD; Henderson MJ; Porro A; Munoz M; Iraci N; Xue C; Murray J; Flemming C; Fletcher J; Gherardi S; Kwek A; Russell A; London WB; Buxton AB; Ashton L; Sartorelli AC; Cohn SL; Schwab M; Marshall GM; Perini G; Haber M, 2011, 'ABCC/MRP multidrug transporters contribute to neuroblastoma biology, pathogenesis and clinical outcome, independently of any role in cytotoxic drug efflux', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, http://dx.doi.org/10.1158/1538-7445.AM2011-954
    Conference Papers | 2011
    Dr Michelle Henderson
    Henderson MJ; Hedditch EL; Russell AJ; deFazio A; Emmanuel C; George J; Chenevix-Trench G; Bowtell D; Norris MD; Haber M, 2011, 'Abstract 1660: Cholesterol efflux transporter gene expression predicts clinical outcome in serous ovarian cancer', in Experimental and Molecular Therapeutics, American Association for Cancer Research, presented at Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL, http://dx.doi.org/10.1158/1538-7445.am2011-1660

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