Karimi L; Alves CL; Terp MG; Tuttolomondo M; Portman N; Ehmsen S; Johansen LE; Bak M; Lim E; Ditzel HJ, 2023, 'Triple combination targeting PI3K, ER, and CDK4/6 inhibits growth of ER-positive breast cancer resistant to fulvestrant and CDK4/6 or PI3K inhibitor', Cancer Communications, 43, pp. 720 - 725, http://dx.doi.org/10.1002/cac2.12425
Journal articles | 2022
Brown LJ; Achinger-Kawecka J; Portman N; Clark S; Stirzaker C; Lim E, 2022, 'Epigenetic Therapies and Biomarkers in Breast Cancer', Cancers, 14, pp. 474 - 474, http://dx.doi.org/10.3390/cancers14030474
Achinger-Kawecka J; Stirzaker C; Portman N; Campbell E; Chia K-M; Du Q; Laven-Law G; Nair S; Yong A; Wilkinson A; Clifton S; Milioli H; Alexandrou S; Caldon E; Song J; Khoury A; Meyer B; Gee JMW; Schmitt A; Wong E; Hickey T; Lim E; Clark S, 2021, 'Epigenetic therapy targets the 3D epigenome in endocrine-resistant breast cancer', , http://dx.doi.org/10.1101/2021.06.21.449340
Journal articles | 2021
Alves CL; Ehmsen S; Terp MG; Portman N; Tuttolomondo M; Gammelgaard OL; Hundebøl MF; Kaminska K; Johansen LE; Bak M; Honeth G; Bosch A; Lim E; Ditzel HJ, 2021, 'Co-targeting CDK4/6 and AKT with endocrine therapy prevents progression in CDK4/6 inhibitor and endocrine therapy-resistant breast cancer', Nature Communications, 12, http://dx.doi.org/10.1038/s41467-021-25422-9
Journal articles | 2021
Alves CL; Ehmsen S; Terp MG; Portman N; Tuttolomondo M; Gammelgaard OL; Hundebøl MF; Kaminska K; Johansen LE; Bak M; Honeth G; Bosch A; Lim E; Ditzel HJ, 2021, 'Publisher Correction: Co-targeting CDK4/6 and AKT with endocrine therapy prevents progression in CDK4/6 inhibitor and endocrine therapy-resistant breast cancer (Nature Communications, (2021), 12, 1, (5112), 10.1038/s41467-021-25422-9)', Nature Communications, 12, pp. 5588, http://dx.doi.org/10.1038/s41467-021-25901-z
Journal articles | 2021
Aziz D; Portman N; Fernandez KJ; Lee C; Alexandrou S; Llop-Guevara A; Phan Z; Yong A; Wilkinson A; Sergio CM; Ferraro D; Etemadmoghadam D; Bowtell DD; Serra V; Waring P; Lim E; Caldon CE, 2021, 'Synergistic targeting of BRCA1 mutated breast cancers with PARP and CDK2 inhibition', npj Breast Cancer, 7, http://dx.doi.org/10.1038/s41523-021-00312-x
Journal articles | 2021
Du Q; Smith GC; Luu PL; Ferguson JM; Armstrong NJ; Caldon CE; Campbell EM; Nair SS; Zotenko E; Gould CM; Buckley M; Chia KM; Portman N; Lim E; Kaczorowski D; Chan CL; Barton K; Deveson IW; Smith MA; Powell JE; Skvortsova K; Stirzaker C; Achinger-Kawecka J; Clark SJ, 2021, 'DNA methylation is required to maintain both DNA replication timing precision and 3D genome organization integrity', Cell Reports, 36, http://dx.doi.org/10.1016/j.celrep.2021.109722
Journal articles | 2021
Freelander A; Brown LJ; Parker A; Segara D; Portman N; Lau B; Lim E, 2021, 'Molecular biomarkers for contemporary therapies in hormone receptor‐positive breast cancer', Genes, 12, pp. 1 - 24, http://dx.doi.org/10.3390/genes12020285
Journal articles | 2021
Portman N; Chen J; Lim E, 2021, 'MDM2 as a Rational Target for Intervention in CDK4/6 Inhibitor Resistant, Hormone Receptor Positive Breast Cancer', Frontiers in Oncology, 11, http://dx.doi.org/10.3389/fonc.2021.777867
Journal articles | 2020
Chia KM; Freelander A; Kumar S; Parker A; Segara D; Portman N; Lim E, 2020, 'Estrogen receptor positive breast cancer patient–derived xenograft models in translational research', Current Opinion in Endocrine and Metabolic Research, 15, pp. 31 - 36, http://dx.doi.org/10.1016/j.coemr.2020.10.004
Journal articles | 2020
Portman N; Milioli HH; Alexandrou S; Coulson R; Yong A; Fernandez KJ; Chia KM; Halilovic E; Segara D; Parker A; Haupt S; Haupt Y; Tilley WD; Swarbrick A; Caldon CE; Lim E, 2020, 'MDM2 inhibition in combination with endocrine therapy and CDK4/6 inhibition for the treatment of ER-positive breast cancer', Breast Cancer Research, 22, pp. 87, http://dx.doi.org/10.1186/s13058-020-01318-2
Journal articles | 2020
Portman N; Milioli HH; Alexandrou S; Coulson R; Yong A; Fernandez KJ; Chia KM; Segara D; Parker A; Haupt S; Haupt Y; Tilley WD; Swarbrick A; Caldon CE; Lim E, 2020, 'MDM2 Inhibition in Combination with Endocrine Therapy and CDK4/6 Inhibition for the Treatment of ER-Positive Breast Cancer', , http://dx.doi.org/10.1101/2020.06.09.140921
Journal articles | 2020
Tadesse S; Anshabo AT; Portman N; Lim E; Tilley W; Caldon CE; Wang S, 2020, 'Targeting CDK2 in cancer: challenges and opportunities for therapy', Drug Discovery Today, 25, pp. 406 - 413, http://dx.doi.org/10.1016/j.drudis.2019.12.001
Journal articles | 2019
Chia KM; Milioli H; Portman N; Laven-Law G; Coulson R; Yong A; Segara D; Parker A; Caldon CE; Deng N; Swarbrick A; Tilley WD; Hickey TE; Lim E, 2019, 'Non-canonical AR activity facilitates endocrine resistance in breast cancer', Endocrine-Related Cancer, 26, pp. 251 - 264, http://dx.doi.org/10.1530/ERC-18-0333
Journal articles | 2019
Kennedy SP; Han JZR; Portman N; Nobis M; Hastings JF; Murphy KJ; Latham SL; Cadell AL; Miladinovic D; Marriott GR; O'Donnell YEI; Shearer RF; Williams JT; Munoz AG; Cox TR; Watkins DN; Saunders DN; Timpson P; Lim E; Kolch W; Croucher DR, 2019, 'Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer', Breast Cancer Research, 21, pp. 43, http://dx.doi.org/10.1186/s13058-019-1127-y
Journal articles | 2019
MacEr-Wright JL; Stanley NR; Portman N; Tan JT; Bursill C; Rayner BS; Hawkins CL, 2019, 'A Role for Chlorinated Nucleosides in the Perturbation of Macrophage Function and Promotion of Inflammation', Chemical Research in Toxicology, 32, pp. 1223 - 1234, http://dx.doi.org/10.1021/acs.chemrestox.9b00044
Journal articles | 2019
Portman N; Alexandrou S; Carson E; Wang S; Lim E; Caldon CE, 2019, 'Overcoming CDK4/6 inhibitor resistance in ER-positive breast cancer', Endocrine-Related Cancer, 26, pp. R15 - R30, http://dx.doi.org/10.1530/ERC-18-0317
Journal articles | 2017
Varga V; Moreira-Leite F; Portman N; Gull K, 2017, 'Protein diversity in discrete structures at the distal tip of the trypanosome flagellum', PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 114, pp. E6546 - E6555, http://dx.doi.org/10.1073/pnas.1703553114
Journal articles | 2016
Lim E; Tarulli G; Portman N; Hickey TE; Tilley WD; Palmieri C, 2016, 'Pushing estrogen receptor around in breast cancer', Endocrine-Related Cancer, 23, pp. T227 - T241, http://dx.doi.org/10.1530/ERC-16-0427
Journal articles | 2014
Foster C; Portman N; Chen M; Šlapeta J, 2014, 'Increased growth and pigment content of Chromera velia in mixotrophic culture', FEMS Microbiology Ecology, 88, pp. 121 - 128, http://dx.doi.org/10.1111/1574-6941.12275
Journal articles | 2014
Portman N; Foster C; Walker G; Slapeta J, 2014, 'Evidence of Intraflagellar Transport and Apical Complex Formation in a Free-Living Relative of the Apicomplexa', EUKARYOTIC CELL, 13, pp. 10 - 20, http://dx.doi.org/10.1128/EC.00155-13
Journal articles | 2014
Portman N; Gull K, 2014, 'Identification of Paralogous Life-Cycle Stage Specific Cytoskeletal Proteins in the Parasite Trypanosoma brucei', PLOS ONE, 9, http://dx.doi.org/10.1371/journal.pone.0106777
Journal articles | 2014
Portman N; Slapeta J, 2014, 'The flagellar contribution to the apical complex: a new tool for the eukaryotic Swiss Army knife?', TRENDS IN PARASITOLOGY, 30, pp. 58 - 64, http://dx.doi.org/10.1016/j.pt.2013.12.006
Journal articles | 2012
Portman N; Gull K, 2012, 'Proteomics and the Trypanosoma brucei cytoskeleton: advances and opportunities', PARASITOLOGY, 139, pp. 1168 - 1177, http://dx.doi.org/10.1017/S0031182012000443
Journal articles | 2010
Portman N; Gull K, 2010, 'The paraflagellar rod of kinetoplastid parasites: From structure to components and function', INTERNATIONAL JOURNAL FOR PARASITOLOGY, 40, pp. 135 - 148, http://dx.doi.org/10.1016/j.ijpara.2009.10.005
Journal articles | 2009
Hart SR; Lau KW; Hao Z; Broadhead R; Portman N; Huehmer A; Gull K; McKean PG; Hubbard SJ; Gaskell SJ, 2009, 'Analysis of the Trypanosome Flagellar Proteome Using a Combined Electron Transfer/Collisionally Activated Dissociation Strategy', JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 20, pp. 167 - 175, http://dx.doi.org/10.1016/j.jasms.2008.08.014
Portman N; Lacomble S; Thomas B; McKean PG; Gull K, 2009, 'Combining RNA Interference Mutants and Comparative Proteomics to Identify Protein Components and Dependences in a Eukaryotic Flagellum', JOURNAL OF BIOLOGICAL CHEMISTRY, 284, pp. 5610 - 5619, http://dx.doi.org/10.1074/jbc.M808859200
Journal articles | 2009
Smith TK; Vasileva N; Gluenz E; Terry S; Portman N; Kramer S; Carrington M; Michaeli S; Gull K; Rudenko G, 2009, 'Blocking Variant Surface Glycoprotein Synthesis in Trypanosoma brucei Triggers a General Arrest in Translation Initiation', PLOS ONE, 4, http://dx.doi.org/10.1371/journal.pone.0007532
Journal articles | 2008
Ginger ML; Portman N; McKean PG, 2008, 'Swimming with protists: perception, motility and flagellum assembly', NATURE REVIEWS MICROBIOLOGY, 6, pp. 838 - 850, http://dx.doi.org/10.1038/nrmicro2009
Journal articles | 2007
Griffiths S; Portman N; Taylor PR; Gordon S; Ginger ML; Gull K, 2007, 'RNA interference mutant induction in vivo demonstrates the essential nature of trypanosome flagellar function during mammalian infection', EUKARYOTIC CELL, 6, pp. 1248 - 1250, http://dx.doi.org/10.1128/EC.00110-07
Journal articles | 2006
Broadhead R; Dawe HR; Farr H; Griffiths S; Hart SR; Portman N; Shaw MK; Ginger ML; Gaskell SJ; McKean PG; Gull K, 2006, 'Flagellar motility is required for the viability of the bloodstream trypanosome', NATURE, 440, pp. 224 - 227, http://dx.doi.org/10.1038/nature04541
Journal articles | 2005
Dawe HR; Farr H; Portman N; Shaw MK; Gull K, 2005, 'The Parkin co-regulated gene product, PACRG, is an evolutionarily conserved axonemal protein that functions in outer-doublet microtubule morphogenesis', JOURNAL OF CELL SCIENCE, 118, pp. 5421 - 5430, http://dx.doi.org/10.1242/jcs.02659
Journal articles | 2001
Drewett V; Devitt A; Saxton J; Portman N; Greaney P; Cheong N; Alnemri TF; Alnemri E; Shaw PE, 2001, 'Serum response factor cleavage by caspases 3 and 7 linked to apoptosis in human BJAB cells', JOURNAL OF BIOLOGICAL CHEMISTRY, 276, pp. 33444 - 33451, http://dx.doi.org/10.1074/jbc.M103877200
Preprints | 2022
Wahlroos S; Portman N; Bonder C; Hjorth M; Wilkinson A; Hastings J; Croucher D; Febbraio M; Gallego-Ortega D; Lim E, 2022, Exercise-induced modulation of the immune microenvironment in pre-clinical breast cancer models., , http://dx.doi.org/10.21203/rs.3.rs-1789675/v1
Conference Papers | 2021
Portman N; Milioli H; Alexandrou S; Coulson R; Yong A; Fernandez K; Chia K; Halilovic E; Segara D; Parker A; Haupt S; Haupt Y; Tilley W; Swarbrick A; Caldon L; Lim E, 2021, 'Abstract PS18-17: Mdm2 inhibition synergises with endocrine therapy or cdk4/6 inhibition for the treatment of estrogen receptor-positive breast cancer', in Cancer Research, American Association for Cancer Research (AACR), presented at Abstracts: 2020 San Antonio Breast Cancer Virtual Symposium; December 8-11, 2020; San Antonio, Texas, http://dx.doi.org/10.1158/1538-7445.sabcs20-ps18-17
Alexandrou S; Milioli HH; Portman N; Lee C; Fernandez K; Blake D; Lim E; Caldon L, 2019, 'S phase dysregulation occurs following resistance to CDK4/6 inhibition ER+ breast cancer', in Oncolabs, presented at 7th PacRim Breast & Prostate Cancer Meeting, http://dx.doi.org/10.1530/oncolabs.1.P001
Conference Abstracts | 2019
Chia KM; Milioli HH; Portman N; Laven-Law G; Coulson R; Young A; Segara D; Parker A; Caldon L; Deng N; Swarbrick A; Tilley W; Hickey T; Lim E, 2019, 'Targeting AR in endocrine-resistant breast cancer', in Oncolabs, presented at 7th PacRim Breast & Prostate Cancer Meeting, http://dx.doi.org/10.1530/oncolabs.1.P012
Conference Abstracts | 2019
Milioli HH; Chia KM; Portman N; Young A; Laven-Law G; Selth L; Tilley WD; Hickey T; Lim E, 2019, 'Androgen receptor activation in Endocrine-Resistant ER-positive breast cancer', in Oncolabs, presented at 7th PacRim Breast & Prostate Cancer Meeting, http://dx.doi.org/10.1530/oncolabs.1.P034
Conference Presentations | 2019
Portman N; Milioli HH; Alexandrou S; Coulson R; Young A; Chia KM; Haup S; Haup Y; Caldon L; Lim E, 2019, 'The MDM2 inhibitor NVP-CGM097 synergises with fulvestrant and inhibits Estrogen Receptor positive breast cancer', presented at Hormone-Dependent Cancers (GRS), Newry, USA
Conference Abstracts | 2019
Portman N; Milioli HH; Young A; Coulson R; Alexandrou S; Lam N; Haup S; Haup Y; Caldon L; Deng N; Lim E, 2019, 'Activation of p53 in combination with endocrine and CDK targeted therapies in ER+ breast cancer', in Oncolabs, presented at 7th PacRim Breast & Prostate Cancer Meeting, http://dx.doi.org/10.1530/oncolabs.1.P043
Conference Abstracts | 2019
Stirzaker C; Chia KM; Portman N; Milioli HH; Clifton S; Achinger-Kawecka J; Nair S; Lim E; Clark S, 2019, 'DNA demethylation agents as a therapeutic approach in endocrine-resistant breast cancer', in Oncolabs, presented at 7th PacRim Breast & Prostate Cancer Meeting, http://dx.doi.org/10.1530/oncolabs.1.P049
Conference Abstracts | 2019
Wahlroos S; Wilkinson A; Milioli H; Portman N; Gallego-Ortega D; Lim E, 2019, 'Concurrent exercise and chemotherapy in preclinical breast cancer models', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, TX, San Antonio, Vol. 80, presented at 42nd Annual San Antonio Breast Cancer Symposium, TX, San Antonio, 09 December 2019 - 14 December 2019, http://dx.doi.org/10.1158/1538-7445.SABCS19-P4-14-13
Conference Abstracts | 2018
Chia KM; Milioli H; Portman N; Laven-Law G; Yong A; Swarbrick A; Caldon L; Tilley W; Hickey T; Lim E, 2018, 'Activation of AR inhibits growth of endocrine-resistant breast cancer', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, TX, San Antonio, Vol. 79, presented at San Antonio Breast Cancer Symposium, TX, San Antonio, 04 December 2018 - 08 December 2018, http://dx.doi.org/10.1158/1538-7445.SABCS18-P6-20-04
Conference Papers | 2018
Lim E; Portman N; Alexandrou S; Haupt S; Haupt Y; Caldon E, 2018, 'Abstract P4-04-12: Therapeutic targeting of CDK4/6 inhibitor resistant breast cancer', in Cancer Research, American Association for Cancer Research (AACR), presented at Abstracts: 2017 San Antonio Breast Cancer Symposium; December 5-9, 2017; San Antonio, Texas, http://dx.doi.org/10.1158/1538-7445.sabcs17-p4-04-12