Conjoint Associate Lecturer

Mr Neil Portman

Medicine & Health
School of Clinical Medicine
  • Journal articles | 2022
    Brown LJ; Achinger-Kawecka J; Portman N; Clark S; Stirzaker C; Lim E, 2022, 'Epigenetic Therapies and Biomarkers in Breast Cancer', Cancers, vol. 14, pp. 474 - 474, http://dx.doi.org/10.3390/cancers14030474
    Journal articles | 2022
    Portman N; Lim E, 2022, 'A new sophistication for breast cancer PDXs', Nature Cancer, vol. 3, pp. 138 - 140, http://dx.doi.org/10.1038/s43018-021-00328-z
    Journal articles | 2021
    Alves CL; Ehmsen S; Terp MG; Portman N; Tuttolomondo M; Gammelgaard OL; Hundebøl MF; Kaminska K; Johansen LE; Bak M; Honeth G; Bosch A; Lim E; Ditzel HJ, 2021, 'Co-targeting CDK4/6 and AKT with endocrine therapy prevents progression in CDK4/6 inhibitor and endocrine therapy-resistant breast cancer', Nature Communications, vol. 12, http://dx.doi.org/10.1038/s41467-021-25422-9
    Journal articles | 2021
    Alves CL; Ehmsen S; Terp MG; Portman N; Tuttolomondo M; Gammelgaard OL; Hundebøl MF; Kaminska K; Johansen LE; Bak M; Honeth G; Bosch A; Lim E; Ditzel HJ, 2021, 'Publisher Correction: Co-targeting CDK4/6 and AKT with endocrine therapy prevents progression in CDK4/6 inhibitor and endocrine therapy-resistant breast cancer (Nature Communications, (2021), 12, 1, (5112), 10.1038/s41467-021-25422-9)', Nature Communications, vol. 12, pp. 5588, http://dx.doi.org/10.1038/s41467-021-25901-z
    Journal articles | 2021
    Aziz D; Portman N; Fernandez KJ; Lee C; Alexandrou S; Llop-Guevara A; Phan Z; Yong A; Wilkinson A; Sergio CM; Ferraro D; Etemadmoghadam D; Bowtell DD; Serra V; Waring P; Lim E; Caldon CE, 2021, 'Synergistic targeting of BRCA1 mutated breast cancers with PARP and CDK2 inhibition', npj Breast Cancer, vol. 7, http://dx.doi.org/10.1038/s41523-021-00312-x
    Journal articles | 2021
    Du Q; Smith GC; Luu PL; Ferguson JM; Armstrong NJ; Caldon CE; Campbell EM; Nair SS; Zotenko E; Gould CM; Buckley M; Chia KM; Portman N; Lim E; Kaczorowski D; Chan CL; Barton K; Deveson IW; Smith MA; Powell JE; Skvortsova K; Stirzaker C; Achinger-Kawecka J; Clark SJ, 2021, 'DNA methylation is required to maintain both DNA replication timing precision and 3D genome organization integrity', Cell Reports, vol. 36, http://dx.doi.org/10.1016/j.celrep.2021.109722
    Journal articles | 2021
    Freelander A; Brown LJ; Parker A; Segara D; Portman N; Lau B; Lim E, 2021, 'Molecular biomarkers for contemporary therapies in hormone receptor‐positive breast cancer', Genes, vol. 12, pp. 1 - 24, http://dx.doi.org/10.3390/genes12020285
    Journal articles | 2021
    Portman N; Chen J; Lim E, 2021, 'MDM2 as a Rational Target for Intervention in CDK4/6 Inhibitor Resistant, Hormone Receptor Positive Breast Cancer', Frontiers in Oncology, vol. 11, http://dx.doi.org/10.3389/fonc.2021.777867
    Journal articles | 2020
    Chia KM; Freelander A; Kumar S; Parker A; Segara D; Portman N; Lim E, 2020, 'Estrogen receptor positive breast cancer patient–derived xenograft models in translational research', Current Opinion in Endocrine and Metabolic Research, vol. 15, pp. 31 - 36, http://dx.doi.org/10.1016/j.coemr.2020.10.004
    Journal articles | 2020
    Portman N; Milioli HH; Alexandrou S; Coulson R; Yong A; Fernandez KJ; Chia KM; Halilovic E; Segara D; Parker A; Haupt S; Haupt Y; Tilley WD; Swarbrick A; Caldon CE; Lim E, 2020, 'MDM2 inhibition in combination with endocrine therapy and CDK4/6 inhibition for the treatment of ER-positive breast cancer', Breast Cancer Research, vol. 22, pp. 87, http://dx.doi.org/10.1186/s13058-020-01318-2
    Journal articles | 2020
    Tadesse S; Anshabo AT; Portman N; Lim E; Tilley W; Caldon CE; Wang S, 2020, 'Targeting CDK2 in cancer: challenges and opportunities for therapy', Drug Discovery Today, vol. 25, pp. 406 - 413, http://dx.doi.org/10.1016/j.drudis.2019.12.001
    Journal articles | 2019
    Chia KM; Milioli H; Portman N; Laven-Law G; Coulson R; Yong A; Segara D; Parker A; Caldon CE; Deng N; Swarbrick A; Tilley WD; Hickey TE; Lim E, 2019, 'Non-canonical AR activity facilitates endocrine resistance in breast cancer', Endocrine-Related Cancer, vol. 26, pp. 251 - 264, http://dx.doi.org/10.1530/ERC-18-0333
    Journal articles | 2019
    Kennedy SP; Han JZR; Portman N; Nobis M; Hastings JF; Murphy KJ; Latham SL; Cadell AL; Miladinovic D; Marriott GR; O'Donnell YEI; Shearer RF; Williams JT; Munoz AG; Cox TR; Watkins DN; Saunders DN; Timpson P; Lim E; Kolch W; Croucher DR, 2019, 'Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer', Breast Cancer Research, vol. 21, pp. 43, http://dx.doi.org/10.1186/s13058-019-1127-y
    Journal articles | 2019
    MacEr-Wright JL; Stanley NR; Portman N; Tan JT; Bursill C; Rayner BS; Hawkins CL, 2019, 'A Role for Chlorinated Nucleosides in the Perturbation of Macrophage Function and Promotion of Inflammation', Chemical Research in Toxicology, vol. 32, pp. 1223 - 1234, http://dx.doi.org/10.1021/acs.chemrestox.9b00044
    Journal articles | 2019
    Portman N; Alexandrou S; Carson E; Wang S; Lim E; Caldon CE, 2019, 'Overcoming CDK4/6 inhibitor resistance in ER-positive breast cancer', Endocrine-Related Cancer, vol. 26, pp. R15 - R30, http://dx.doi.org/10.1530/ERC-18-0317
    Journal articles | 2017
    Varga V; Moreira-Leite F; Portman N; Gull K, 2017, 'Protein diversity in discrete structures at the distal tip of the trypanosome flagellum', PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 114, pp. E6546 - E6555, http://dx.doi.org/10.1073/pnas.1703553114
    Journal articles | 2016
    Lim E; Tarulli G; Portman N; Hickey TE; Tilley WD; Palmieri C, 2016, 'Pushing estrogen receptor around in breast cancer', Endocrine-Related Cancer, vol. 23, pp. T227 - T241, http://dx.doi.org/10.1530/ERC-16-0427
    Journal articles | 2014
    Foster C; Portman N; Chen M; Šlapeta J, 2014, 'Increased growth and pigment content of Chromera velia in mixotrophic culture', FEMS Microbiology Ecology, vol. 88, pp. 121 - 128, http://dx.doi.org/10.1111/1574-6941.12275
    Journal articles | 2014
    Portman N; Foster C; Walker G; Slapeta J, 2014, 'Evidence of Intraflagellar Transport and Apical Complex Formation in a Free-Living Relative of the Apicomplexa', EUKARYOTIC CELL, vol. 13, pp. 10 - 20, http://dx.doi.org/10.1128/EC.00155-13
    Journal articles | 2014
    Portman N; Gull K, 2014, 'Identification of Paralogous Life-Cycle Stage Specific Cytoskeletal Proteins in the Parasite Trypanosoma brucei', PLOS ONE, vol. 9, http://dx.doi.org/10.1371/journal.pone.0106777
    Journal articles | 2014
    Portman N; Slapeta J, 2014, 'The flagellar contribution to the apical complex: a new tool for the eukaryotic Swiss Army knife?', TRENDS IN PARASITOLOGY, vol. 30, pp. 58 - 64, http://dx.doi.org/10.1016/j.pt.2013.12.006
    Journal articles | 2012
    Portman N; Gull K, 2012, 'Proteomics and the Trypanosoma brucei cytoskeleton: advances and opportunities', PARASITOLOGY, vol. 139, pp. 1168 - 1177, http://dx.doi.org/10.1017/S0031182012000443
    Journal articles | 2010
    Portman N; Gull K, 2010, 'The paraflagellar rod of kinetoplastid parasites: From structure to components and function', INTERNATIONAL JOURNAL FOR PARASITOLOGY, vol. 40, pp. 135 - 148, http://dx.doi.org/10.1016/j.ijpara.2009.10.005
    Journal articles | 2009
    Hart SR; Lau KW; Hao Z; Broadhead R; Portman N; Huehmer A; Gull K; McKean PG; Hubbard SJ; Gaskell SJ, 2009, 'Analysis of the Trypanosome Flagellar Proteome Using a Combined Electron Transfer/Collisionally Activated Dissociation Strategy', JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, vol. 20, pp. 167 - 175, http://dx.doi.org/10.1016/j.jasms.2008.08.014
    Journal articles | 2009
    Lacomble S; Portman N; Gull K, 2009, 'A Protein-Protein Interaction Map of the Trypanosoma brucei Paraflagellar Rod', PLOS ONE, vol. 4, http://dx.doi.org/10.1371/journal.pone.0007685
    Journal articles | 2009
    Portman N; Lacomble S; Thomas B; McKean PG; Gull K, 2009, 'Combining RNA Interference Mutants and Comparative Proteomics to Identify Protein Components and Dependences in a Eukaryotic Flagellum', JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 284, pp. 5610 - 5619, http://dx.doi.org/10.1074/jbc.M808859200
    Journal articles | 2009
    Smith TK; Vasileva N; Gluenz E; Terry S; Portman N; Kramer S; Carrington M; Michaeli S; Gull K; Rudenko G, 2009, 'Blocking Variant Surface Glycoprotein Synthesis in Trypanosoma brucei Triggers a General Arrest in Translation Initiation', PLOS ONE, vol. 4, http://dx.doi.org/10.1371/journal.pone.0007532
    Journal articles | 2008
    Ginger ML; Portman N; McKean PG, 2008, 'Swimming with protists: perception, motility and flagellum assembly', NATURE REVIEWS MICROBIOLOGY, vol. 6, pp. 838 - 850, http://dx.doi.org/10.1038/nrmicro2009
    Journal articles | 2007
    Griffiths S; Portman N; Taylor PR; Gordon S; Ginger ML; Gull K, 2007, 'RNA interference mutant induction in vivo demonstrates the essential nature of trypanosome flagellar function during mammalian infection', EUKARYOTIC CELL, vol. 6, pp. 1248 - 1250, http://dx.doi.org/10.1128/EC.00110-07
    Journal articles | 2006
    Broadhead R; Dawe HR; Farr H; Griffiths S; Hart SR; Portman N; Shaw MK; Ginger ML; Gaskell SJ; McKean PG; Gull K, 2006, 'Flagellar motility is required for the viability of the bloodstream trypanosome', NATURE, vol. 440, pp. 224 - 227, http://dx.doi.org/10.1038/nature04541
    Journal articles | 2005
    Dawe HR; Farr H; Portman N; Shaw MK; Gull K, 2005, 'The Parkin co-regulated gene product, PACRG, is an evolutionarily conserved axonemal protein that functions in outer-doublet microtubule morphogenesis', JOURNAL OF CELL SCIENCE, vol. 118, pp. 5421 - 5430, http://dx.doi.org/10.1242/jcs.02659
    Journal articles | 2001
    Drewett V; Devitt A; Saxton J; Portman N; Greaney P; Cheong N; Alnemri TF; Alnemri E; Shaw PE, 2001, 'Serum response factor cleavage by caspases 3 and 7 linked to apoptosis in human BJAB cells', JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 276, pp. 33444 - 33451, http://dx.doi.org/10.1074/jbc.M103877200
    Journal articles |
    Achinger-Kawecka J; Stirzaker C; Chia K-M; Portman N; Campbell E; Du Q; Laven-Law G; Nair SS; Yong A; Wilkinson A; Clifton S; Milioli HH; Schmitt A; Wong ES; Hickey TE; Lim E; Clark SJ, 'Epigenetic therapy suppresses endocrine-resistant breast tumour growth by re-wiring ER-mediated 3D chromatin interactions', , http://dx.doi.org/10.1101/2021.06.21.449340
    Journal articles |
    Portman N; Milioli HH; Alexandrou S; Coulson R; Yong A; Fernandez KJ; Chia KM; Segara D; Parker A; Haupt S; Haupt Y; Tilley WD; Swarbrick A; Caldon CE; Lim E, 'MDM2 Inhibition in Combination with Endocrine Therapy and CDK4/6 Inhibition for the Treatment of ER-Positive Breast Cancer', , http://dx.doi.org/10.1101/2020.06.09.140921
  • Conference Papers | 2021
    Portman N; Milioli H; Alexandrou S; Coulson R; Yong A; Fernandez K; Chia K; Halilovic E; Segara D; Parker A; Haupt S; Haupt Y; Tilley W; Swarbrick A; Caldon L; Lim E, 2021, 'Abstract PS18-17: Mdm2 inhibition synergises with endocrine therapy or cdk4/6 inhibition for the treatment of estrogen receptor-positive breast cancer', in Poster Session Abstracts, American Association for Cancer Research, presented at Abstracts: 2020 San Antonio Breast Cancer Virtual Symposium; December 8-11, 2020; San Antonio, Texas, http://dx.doi.org/10.1158/1538-7445.sabcs20-ps18-17
    Conference Abstracts | 2019
    Alexandrou S; Milioli HH; Portman N; Lee C; Fernandez K; Blake D; Lim E; Caldon L, 2019, 'S phase dysregulation occurs following resistance to CDK4/6 inhibition ER+ breast cancer', in Oncolabs, presented at 7th PacRim Breast & Prostate Cancer Meeting, http://dx.doi.org/10.1530/oncolabs.1.P001
    Conference Abstracts | 2019
    Chia KM; Milioli HH; Portman N; Laven-Law G; Coulson R; Young A; Segara D; Parker A; Caldon L; Deng N; Swarbrick A; Tilley W; Hickey T; Lim E, 2019, 'Targeting AR in endocrine-resistant breast cancer', in Oncolabs, presented at 7th PacRim Breast & Prostate Cancer Meeting, http://dx.doi.org/10.1530/oncolabs.1.P012
    Conference Abstracts | 2019
    Milioli HH; Chia KM; Portman N; Young A; Laven-Law G; Selth L; Tilley WD; Hickey T; Lim E, 2019, 'Androgen receptor activation in Endocrine-Resistant ER-positive breast cancer', in Oncolabs, presented at 7th PacRim Breast & Prostate Cancer Meeting, http://dx.doi.org/10.1530/oncolabs.1.P034
    Conference Presentations | 2019
    Portman N; Milioli HH; Alexandrou S; Coulson R; Young A; Chia KM; Haup S; Haup Y; Caldon L; Lim E, 2019, 'The MDM2 inhibitor NVP-CGM097 synergises with fulvestrant and inhibits Estrogen Receptor positive breast cancer', presented at Hormone-Dependent Cancers (GRS), Newry, USA
    Conference Abstracts | 2019
    Portman N; Milioli HH; Young A; Coulson R; Alexandrou S; Lam N; Haup S; Haup Y; Caldon L; Deng N; Lim E, 2019, 'Activation of p53 in combination with endocrine and CDK targeted therapies in ER+ breast cancer', in Oncolabs, presented at 7th PacRim Breast & Prostate Cancer Meeting, http://dx.doi.org/10.1530/oncolabs.1.P043
    Conference Abstracts | 2019
    Stirzaker C; Chia KM; Portman N; Milioli HH; Clifton S; Achinger-Kawecka J; Nair S; Lim E; Clark S, 2019, 'DNA demethylation agents as a therapeutic approach in endocrine-resistant breast cancer', in Oncolabs, presented at 7th PacRim Breast & Prostate Cancer Meeting, http://dx.doi.org/10.1530/oncolabs.1.P049
    Conference Abstracts | 2019
    Wahlroos S; Wilkinson A; Milioli H; Portman N; Gallego-Ortega D; Lim E, 2019, 'Concurrent exercise and chemotherapy in preclinical breast cancer models', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, San Antonio, TX, Vol. 80, presented at 42nd Annual San Antonio Breast Cancer Symposium, San Antonio, TX, 09 December 2019 - 14 December 2019, http://dx.doi.org/10.1158/1538-7445.SABCS19-P4-14-13
    Conference Abstracts | 2018
    Chia KM; Milioli H; Portman N; Laven-Law G; Yong A; Swarbrick A; Caldon L; Tilley W; Hickey T; Lim E, 2018, 'Activation of AR inhibits growth of endocrine-resistant breast cancer', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, San Antonio, TX, Vol. 79, presented at San Antonio Breast Cancer Symposium, San Antonio, TX, 04 December 2018 - 08 December 2018, http://dx.doi.org/10.1158/1538-7445.SABCS18-P6-20-04
    Conference Papers | 2018
    Lim E; Portman N; Alexandrou S; Haupt S; Haupt Y; Caldon E, 2018, 'Abstract P4-04-12: Therapeutic targeting of CDK4/6 inhibitor resistant breast cancer', in Poster Session Abstracts, American Association for Cancer Research, presented at Abstracts: 2017 San Antonio Breast Cancer Symposium; December 5-9, 2017; San Antonio, Texas, http://dx.doi.org/10.1158/1538-7445.sabcs17-p4-04-12
    Conference Abstracts | 2017
    Lim E; Portman N; Alexandrou S; Haupt S; Haupt Y; Caldon E, 2017, 'Therapeutic targeting of CDK4/6 inhibitor resistant breast cancer', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, San Antonio, TX, Vol. 78, presented at San Antonio Breast Cancer Symposium, San Antonio, TX, 05 December 2017 - 09 December 2017, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000425489401175&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Preprints |
    Aziz D; Portman N; Fernandez KJ; Lee C; Alexandrou S; Llop-Guevara A; Yong A; Wilkinson A; Sergio CM; Ferraro D; Etemadmoghadam D; Bowtell D; Investigators K; Serra V; Waring P; Lim E; Caldon CE, Cyclin E1 protein is stabilized in BRCA1 mutated breast cancers leading to synergy between CDK2 and PARP inhibitors, http://dx.doi.org/10.1101/2020.01.29.911883