Completed my PhD in the roles of epigenetic regulation in human cancer, with particular focus on ncRNAs. My current research area involves understanding the epigenetic regulation of the X chromosome in the Waters lab. Dosage compensation and sex determination are both areas of particular interest.
Lister NC; Johnsson P; Waters PD; Morris KV, 2021, 'Pseudogenes: A Novel Source of Trans-Acting Antisense RNAs', in Pseudogenes: Functions and Protocols, pp. 219 - 236, http://dx.doi.org/10.1007/978-1-0716-1503-4_14
Journal articles | 2025
Patel HR; Alreja K; Reis ALM; Chang JK; Chew ZA; Jung H; Hammond JM; Deveson IW; Ruiz-Herrera A; Marin-Gual L; Holleley CE; Zhang X; Lister NC; Whiteley S; Xiong L; Dissanayake DSB; Waters PD; Georges A, 2025, 'A near telomere-to-telomere phased genome assembly and annotation for the Australian central bearded dragon Pogona vitticeps', Gigascience, 14, http://dx.doi.org/10.1093/gigascience/giaf085
Journal articles | 2024
Lister NC; Milton AM; Patel HR; Waters SA; Hanrahan BJ; McIntyre KL; Livernois AM; Horspool WB; Wee LK; Ringel AR; Mundlos S; Robson MI; Shearwin-Whyatt L; Grützner F; Marshall Graves JA; Ruiz-Herrera A; Waters PD, 2024, 'Incomplete transcriptional dosage compensation of chicken and platypus sex chromosomes is balanced by post-transcriptional compensation', Proceedings of the National Academy of Sciences of the United States of America, 121, http://dx.doi.org/10.1073/pnas.2322360121
Journal articles | 2024
Milton AM; Marín-Gual L; Lister NC; McIntyre KL; Grady PGS; Laird MK; Bond DM; Hore TA; O’Neill RJ; Pask AJ; Renfree MB; Ruiz-Herrera A; Waters PD, 2024, 'Imprinted X chromosome inactivation in marsupials: The paternal X arrives at the egg with a silent DNA methylation profile', Proceedings of the National Academy of Sciences of the United States of America, 121, http://dx.doi.org/10.1073/pnas.2412185121
Journal articles | 2023
Bond DM; Ortega-Recalde O; Laird MK; Hayakawa T; Richardson KS; Reese FCB; Kyle B; McIsaac-Williams BE; Robertson BC; van Heezik Y; Adams AL; Chang WS; Haase B; Mountcastle J; Driller M; Collins J; Howe K; Go Y; Thibaud-Nissen F; Lister NC; Waters PD; Fedrigo O; Jarvis ED; Gemmell NJ; Alexander A; Hore TA, 2023, 'The admixed brushtail possum genome reveals invasion history in New Zealand and novel imprinted genes', Nature Communications, 14, http://dx.doi.org/10.1038/s41467-023-41784-8
Journal articles | 2022
Álvarez-González L; Arias-Sardá C; Montes-Espuña L; Marín-Gual L; Vara C; Lister NC; Cuartero Y; Garcia F; Deakin J; Renfree MB; Robinson TJ; Martí-Renom MA; Waters PD; Farré M; Ruiz-Herrera A, 2022, 'Principles of 3D chromosome folding and evolutionary genome reshuffling in mammals', Cell Reports, 41, http://dx.doi.org/10.1016/j.celrep.2022.111839
Journal articles | 2021
Lister NC; Milton AM; Hanrahan BJ; Waters PD, 2021, 'Between the devil and the deep blue sea: Non-coding rnas associated with transmissible cancers in tasmanian devil, domestic dog and bivalves', Non Coding RNA, 7, http://dx.doi.org/10.3390/ncrna7040072
Journal articles | 2021
Waters P; Patel H; Ruiz-Herrera A; Álvarez-González L; Lister N; Simakov O; Ezaz T; Kaur P; Frere C; Grützner F; Georges A; Graves JM, 2021, 'Microchromosomes are building blocks of bird, reptile and mammal chromosomes', , http://dx.doi.org/10.1101/2021.07.06.451394
Journal articles | 2021
Waters PD; Patel HR; Ruiz-Herrera A; Alvarez-Gonzalez L; Lister NC; Simakov O; Ezaz T; Kaur P; Frere C; Grutzner F; Georges A; Marshall Graves JA, 2021, 'Microchromosomes are building blocks of bird, reptile, and mammal chromosomes', Proceedings of the National Academy of Sciences of the United States of America, 118, http://dx.doi.org/10.1073/pnas.2112494118
Journal articles | 2017
Johnsson P; Lister N; Shevchenko G; Walshe J; Ataide SF; Morris KV, 2017, 'Reply to Liu et al.: Yin and yang of PTEN regulation', Proceedings of the National Academy of Sciences of the United States of America, 114, pp. E10512 - E10513, http://dx.doi.org/10.1073/pnas.1718258114
Journal articles | 2017
Lister N; Shevchenko G; Walshe JL; Groen J; Johnsson P; Vidarsdóttir L; Grander D; Ataide SF; Morris KV, 2017, 'The molecular dynamics of long noncoding RNA control of transcription in PTEN and its pseudogene', Proceedings of the National Academy of Sciences of the United States of America, 114, pp. 9942 - 9947, http://dx.doi.org/10.1073/pnas.1621490114
Journal articles | 2015
Lister NC; Clemson M; Morris KV, 2015, 'RNA-directed epigenetic silencing of Periostin inhibits cell motility', Royal Society Open Science, 2, http://dx.doi.org/10.1098/rsos.140545
Preprints | 2025
Patel H; Alreja K; Reis ALM; Chang K; Chew Z; Jung H; Hammond J; Deveson I; Ruiz-Herrera A; Marin-Gual L; Holleley C; Zhang X; Lister N; Whiteley S; Xiong L; Dissanayake DSB; Waters P; Georges A, 2025, A telomere to telomere phased genome assembly and annotation for the Australian central bearded dragon Pogona vitticeps, http://dx.doi.org/10.1101/2025.05.01.651798
Preprints | 2023
Hanrahan B; Chang K; Milton A; Lister N; Dissanayake DSB; Hammond J; Reis ALM; Deveson I; Ruiz-Herrera A; Patel H; Graves JM; Georges A; Waters P, 2023, Sex chromosome dosage compensation in a sex reversing skink is not influenced by sexual phenotype, http://dx.doi.org/10.1101/2023.08.24.554710
Preprints | 2023
Lister N; Milton A; Patel H; Waters S; Hanrahan B; McIntyre K; Livernois A; Wee LK; Ringel A; Mundlos S; Robson M; Shearwin-Whyatt L; Grützner F; Marshall Graves J; Ruiz-Herrera A; Waters P, 2023, Incomplete transcriptional dosage compensation of vertebrate sex chromosomes is balanced by post-transcriptional compensation, http://dx.doi.org/10.1101/2023.02.23.529605
Preprints | 2021
Waters P; Patel H; Ruiz-Herrera A; Álvarez-González L; Lister N; Simakov O; Ezaz T; Kaur P; Frere C; Grützner F; Georges A; Graves JM, 2021, Microchromosomes are building blocks of bird, reptile and mammal chromosomes, http://dx.doi.org/10.1101/2021.07.06.451394
The Waters lab focuses on better understanding the epigenetic regulation of transcription in diverse vertebrate representatives, specifically focussing on sex chromosomes. The ultimate goal is to understand how complex epigenetic silencing mechanisms evolved. We use eutherian, marsupial, monotreme and bird/reptile models. Representatives from these groups each have different (sometimes weird and wonderful) sex determining mechanisms and sex chromosome systems.
We examine X chromosome inactivation in wallabies and Tasmanian devils. We have particular interest in dosage compensation of the strange sex chromosomes of platypus, which have 5 X chromosomes and 5 Y chromosomes! We also study the Australian central bearded dragon, which are unusual in that they have both genetic and environmental sex determination.
