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Professor Nieng Yan
Visiting Professorial Fellow

Professor Nieng Yan

Science
School of Biotech & Biomolecular Science

Biography

Dr Nieng Yan received her B.S. degree from the Department of Biological Sciences & Biotechnology, Tsinghua University, Beijing, China, in 2000. She then pursued her PhD in the Department of Molecular Biology at Princeton University under the supervision of Prof. Yigong Shi between 2000 and 2004. She was the regional winner of the Young Scientist Award (North America) co-sponsored by Science/AAAS and GE Healthcare in 2005 for her thesis on the structural and mechanistic study of programmed cell death.

Dr Yan continued her postdoctoral training at Princeton University, focusing on the structural characterization of intramembrane proteases. In 2007, she joined the faculty of School of Medicine, Tsinghua University. Her lab has been mainly focusing on the structural and functional study of membrane transport proteins exemplified by the glucose transporters and Nav/Cavchannels. In 2012 and 2013, she was promoted to tenured professor and Bayer Endowed Chair Professor, respectively.

Dr Yan returned to Princeton University as the founding Shirley M. Tilghman Professor of Molecular Biology in 2017. Dr. Yan was an HHMI international early career scientist in 2012-2017, the recipient of the 2015 Protein Society Young Investigator Award, the 2015 Beverley & Raymond Sackler International Prize in Biophysics, the Alexander M. Cruickshank Award at the GRC on membrane transport proteins in 2016, the 2018 FAOBMB Award for Research Excellence, and the 2019 Weizmann Women & Science Award. She was elected as a Foreign Associate of the US National Academy of Sciences in 2019.

Professor Yan joined the School for Biotechnology and Biomolecular Sciences in the Faculty of Science as a Visiting Professorship under the UNSW SHARP Program in 2019.
  • Journal articles | 2022
    Jiang X; Yan N; Deng D; Yan C, 2022, 'Structural aspects of the glucose and monocarboxylate transporters involved in the Warburg effect', IUBMB Life, 74, pp. 1180 - 1199, http://dx.doi.org/10.1002/iub.2668
    Journal articles | 2022
    Wang N; Zhang S; Yuan Y; Xu H; Defossa E; Matter H; Besenius M; Derdau V; Dreyer M; Halland N; He KH; Petry S; Podeschwa M; Tennagels N; Jiang X; Yan N, 2022, 'Molecular basis for inhibiting human glucose transporters by exofacial inhibitors', Nature Communications, 13, http://dx.doi.org/10.1038/s41467-022-30326-3
    Journal articles | 2021
    Gao S; Yan N, 2021, 'Structural Basis of the Modulation of the Voltage-Gated Calcium Ion Channel Cav1.1 by Dihydropyridine Compounds**', Angewandte Chemie - International Edition, 60, pp. 3131 - 3137, http://dx.doi.org/10.1002/anie.202011793
    Journal articles | 2021
    Gong D; Yan N; Ledford HA, 2021, 'Structural Basis for the Modulation of Ryanodine Receptors', Trends in Biochemical Sciences, 46, pp. 489 - 501, http://dx.doi.org/10.1016/j.tibs.2020.11.009
    Journal articles | 2021
    Huang J; Yuan Y; Zhao N; Pu D; Tang Q; Zhang S; Luo S; Yang X; Wang N; Xiao Y; Zhang T; Liu Z; Sakata-Kato T; Jiang X; Kato N; Yan N; Yin H, 2021, 'Orthosteric–allosteric dual inhibitors of PfHT1 as selective antimalarial agents', Proceedings of the National Academy of Sciences of the United States of America, 118, http://dx.doi.org/10.1073/pnas.2017749118
    Journal articles | 2021
    Li Z; Jin X; Wu T; Huang G; Wu K; Lei J; Pan X; Yan N, 2021, 'Structural Basis for Pore Blockade of the Human Cardiac Sodium Channel Nav1.5 by the Antiarrhythmic Drug Quinidine**', Angewandte Chemie - International Edition, 60, pp. 11474 - 11480, http://dx.doi.org/10.1002/anie.202102196
    Journal articles | 2021
    Li Z; Jin X; Wu T; Zhao X; Wang W; Lei J; Pan X; Yan N, 2021, 'Structure of human Nav1.5 reveals the fast inactivation-related segments as a mutational hotspot for the long QT syndrome', Proceedings of the National Academy of Sciences of the United States of America, 118, http://dx.doi.org/10.1073/PNAS.2100069118
    Journal articles | 2021
    Pan X; Li Z; Jin X; Zhao Y; Huang G; Huang X; Shen Z; Cao Y; Dong M; Lei J; Yan N, 2021, 'Comparative structural analysis of human Nav1.1 and Nav1.5 reveals mutational hotspots for sodium channelopathies', Proceedings of the National Academy of Sciences of the United States of America, 118, http://dx.doi.org/10.1073/PNAS.2100066118
    Journal articles | 2021
    Yan R; Cao P; Song W; Qian H; Du X; Coates HW; Zhao X; Li Y; Gao S; Gong X; Liu X; Sui J; Lei J; Yang H; Brown AJ; Zhou Q; Yan C; Yan N, 2021, 'A structure of human scap bound to insig-2 suggests how their interaction is regulated by sterols', Science, 371, http://dx.doi.org/10.1126/science.abb2224
    Journal articles | 2020
    Gao S; Valinsky WC; On NC; Houlihan PR; Qu Q; Liu L; Pan X; Clapham DE; Yan N, 2020, 'Employing NaChBac for cryo-EM analysis of toxin action on voltage-gated Na+ channels in nanodisc', Proc. Natl. Acad. Sci. U.S.A.
    Journal articles | 2020
    Jiang X; Yuan Y; Huang J; Zhang S; Luo S; Wang N; Pu D; Zhao N; Tang Q; Hirata K; Yang X; Jiao Y; Sakata-Kato T; Wu JW; Yan C; Kato N; Yin H; Yan N, 2020, 'Structural Basis for Blocking Sugar Uptake into the Malaria Parasite Plasmodium falciparum', Cell, 183, pp. 258 - 268.e12, http://dx.doi.org/10.1016/j.cell.2020.08.015
    Journal articles | 2020
    Pan Y; Ren Z; Gao S; Shen J; Wang L; Xu Z; Yu Y; Bachina P; Zhang H; Fan X; Laganowsky A; Yan N; Zhou M, 2020, 'Structural basis of ion transport and inhibition in ferroportin', Nature Communications, 11, http://dx.doi.org/10.1038/s41467-020-19458-6
    Journal articles | 2020
    Qian H; Wu X; Du X; Yao X; Zhao X; Lee J; Yang H; Yan N, 2020, 'Structural Basis of Low-pH-Dependent Lysosomal Cholesterol Egress by NPC1 and NPC2', Cell
    Journal articles | 2020
    Qian H; Zhao X; Yan R; Yao X; Gao S; Sun X; Du X; Yang H; Wong CCL; Yan N, 2020, 'Structural basis for catalysis and substrate specificity of human ACAT1', Nature, 581, pp. 333 - 338, http://dx.doi.org/10.1038/s41586-020-2290-0
    Journal articles | 2020
    Thomas C; Aller SG; Beis K; Carpenter EP; Chang G; Chen L; Dassa E; Dean M; Duong Van Hoa F; Ekiert D; Ford R; Gaudet R; Gong X; Holland IB; Huang Y; Kahne DK; Kato H; Koronakis V; Koth CM; Lee Y; Lewinson O; Lill R; Martinoia E; Murakami S; Pinkett HW; Poolman B; Rosenbaum D; Sarkadi B; Schmitt L; Schneider E; Shi Y; Shyng SL; Slotboom DJ; Tajkhorshid E; Tieleman DP; Ueda K; Váradi A; Wen PC; Yan N; Zhang P; Zheng H; Zimmer J; Tampé R, 2020, 'Structural and functional diversity calls for a new classification of ABC transporters', FEBS Letters, 594, pp. 3767 - 3775, http://dx.doi.org/10.1002/1873-3468.13935
    Journal articles | 2020
    Wang L; Qian H; Nian Y; Han Y; Ren Z; Zhang H; Hu L; Prasad BVV; Laganowsky A; Yan N; Zhou M, 2020, 'Structure and mechanism of human diacylglycerol O-acyltransferase 1', Nature, 581, pp. 329 - 332
    Journal articles | 2020
    Yao X; Fan X; Yan N, 2020, 'Cryo-EM analysis of a membrane protein embedded in the liposome', Proceedings of the National Academy of Sciences of the United States of America, 117, pp. 18497 - 18503, http://dx.doi.org/10.1073/pnas.2009385117
    Journal articles | 2019
    Brown AJ; Chua NK; Yan N, 2019, 'The shape of human squalene epoxidase expands the arsenal against cancer', Nat Commun, 10, pp. 888 - 888, http://dx.doi.org/10.1038/s41467-019-08866-y
    Journal articles | 2019
    Jiang X; Wu J; Ke M; Zhang S; Yuan Y; Lin JY; Yan N, 2019, 'Engineered XylE as a tool for mechanistic investigation and ligand discovery of the glucose transporters GLUTs', Cell Discov, 5, pp. 14 - 14, http://dx.doi.org/10.1038/s41421-019-0082-1
    Journal articles | 2019
    Shen H; Liu D; Wu K; Lei J; Yan N, 2019, 'Structures of human Nav1.7 channel in complex with auxiliary subunits and animal toxins', Science, 363, pp. 1303 - 1308
    Journal articles | 2018
    Deng D; Yan N, 2018, 'Crystallization and Structural Determination of the Human Glucose Transporters GLUT1 and GLUT3', Methods Mol. Biol., 1713, pp. 15 - 29
    Journal articles | 2018
    Shen H; Li Z; Jiang Y; Pan X; Wu J; Cristofori-Armstrong B; Smith JJ; Chin YKY; Lei J; Zhou Q; King GF; Yan N, 2018, 'Structural basis for the modulation of voltage-gated sodium channels by animal toxins', Science, 362, http://dx.doi.org/10.1126/science.aau2596
    Journal articles | 2018
    Yan R; Qian H; Lukmantara I; Gao M; Du X; Yan N; Yang H, 2018, 'Human SEIPIN Binds Anionic Phospholipids', Dev. Cell, 47, pp. 248 - 256, http://dx.doi.org/10.1016/j.devcel.2018.09.010
    Journal articles | 2017
    Ke M; Yuan Y; Jiang X; Yan N; Gong H, 2017, 'Molecular determinants for the thermodynamic and functional divergence of uniporter GLUT1 and proton symporter XylE', PLoS Comput. Biol., 13, pp. e1005603 - e1005603, http://dx.doi.org/10.1371/journal.pcbi.1005603
    Journal articles | 2017
    Qian H; Zhao X; Cao P; Lei J; Yan N; Gong X, 2017, 'Structure of the Human Lipid Exporter ABCA1', Cell, 169, pp. 1228 - 1239
    Journal articles | 2017
    Wu J; Yan N; Yan Z, 2017, 'Structure-Function Relationship of the Voltage-Gated Calcium Channel Cav1.1 Complex', Adv. Exp. Med. Biol., 981, pp. 23 - 39
    Journal articles | 2017
    Yan Z; Zhou Q; Wang L; Wu J; Zhao Y; Huang G; Peng W; Shen H; Lei J; Yan N, 2017, 'Structure of the Nav1.4-β1 Complex from Electric Eel', Cell, 170, pp. 470 - 482
    Journal articles | 2017
    Yu X; Yang G; Yan C; Baylon JL; Jiang J; Fan H; Lu G; Hasegawa K; Okumura H; Wang T; Tajkhorshid E; Li S; Yan N, 2017, 'Dimeric structure of the uracil:proton symporter UraA provides mechanistic insights into the SLC4/23/26 transporters', Cell Res., 27, pp. 1020 - 1033
    Journal articles | 2016
    Deng D; Yan N, 2016, 'GLUT, SGLT, and SWEET: Structural and mechanistic investigations of the glucose transporters', Protein Sci., 25, pp. 546 - 558
    Journal articles | 2016
    Gong X; Qian H; Shao W; Li J; Wu J; Liu JJ; Li W; Wang HW; Espenshade P; Yan N, 2016, 'Complex structure of the fission yeast SREBP-SCAP binding domains reveals an oligomeric organization', Cell Res., 26, pp. 1197 - 1211
    Journal articles | 2016
    Gong X; Qian H; Zhou X; Wu J; Wan T; Cao P; Huang W; Zhao X; Wang X; Wang P; Shi Y; Gao GF; Zhou Q; Yan N, 2016, 'Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection', Cell, 165, pp. 1467 - 1478
    Journal articles | 2016
    Jiang X; Smirnova I; Kasho V; Wu J; Hirata K; Ke M; Pardon E; Steyaert J; Yan N; Kaback HR, 2016, 'Crystal structure of a LacY-nanobody complex in a periplasmic-open conformation', Proc. Natl. Acad. Sci. U.S.A., 113, pp. 12420 - 12425, http://dx.doi.org/10.1073/pnas.1615414113
    Journal articles | 2015
    Deng D; Sun P; Yan C; Ke M; Jiang X; Xiong L; Ren W; Hirata K; Yamamoto M; Fan S; Yan N, 2015, 'Molecular basis of ligand recognition and transport by glucose transporters', Nature, 526, pp. 391 - 396, http://dx.doi.org/10.1038/nature14655
    Journal articles | 2015
    Fern N-C; Yan N; Dionne J; Bassett D; Sebastian S; Hendon C; Schlichting H; Baker M, 2015, 'Hopes for the year ahead', Nature, 517, pp. 111 - 113
    Journal articles | 2015
    Gong X; Li J; Shao W; Wu J; Qian H; Ren R; Espenshade P; Yan N, 2015, 'Structure of the WD40 domain of SCAP from fission yeast reveals the molecular basis for SREBP recognition', Cell Res., 25, pp. 401 - 411
    Journal articles | 2015
    Ren R; Zhou X; He Y; Ke M; Wu J; Liu X; Yan C; Wu Y; Gong X; Lei X; Yan SF; Radhakrishnan A; Yan N, 2015, 'Crystal structure of a mycobacterial Insig homolog provides insight into how these sensors monitor sterol levels', Science, 349, pp. 187 - 191, http://dx.doi.org/10.1126/science.aab1091
    Journal articles | 2015
    Ren R; Zhou X; He Y; Ke M; Wu J; Liu X; Yan C; Wu Y; Gong X; Lei X; Yan SF; Radhakrishnan A; Yan N, 2015, 'PROTEIN STRUCTURE. Crystal structure of a mycobacterial Insig homolog provides insight into how these sensors monitor sterol levels', Science, 349, pp. 187 - 191
    Journal articles | 2015
    Shen C; Wang X; Liu Y; Li Q; Yang Z; Yan N; Zou T; Yin P, 2015, 'Specific RNA recognition by designer pentatricopeptide repeat protein', Mol Plant, 8, pp. 667 - 670
    Journal articles | 2015
    Wu J; Yan Z; Li Z; Yan C; Lu S; Dong M; Yan N, 2015, 'Structure of the voltage-gated calcium channel Cav1.1 complex', Science, 350, pp. aad2395 - aad2395
    Journal articles | 2015
    Yan N, 2015, 'Structural Biology of the Major Facilitator Superfamily Transporters', Annu Rev Biophys, 44, pp. 257 - 283
    Journal articles | 2015
    Yan Z; Bai X; Yan C; Wu J; Li Z; Xie T; Peng W; Yin C; Li X; Scheres SHW; Shi Y; Yan N, 2015, 'Structure of the rabbit ryanodine receptor RyR1 at near-atomic resolution', Nature, 517, pp. 50 - 55
    Journal articles | 2014
    Deng D; Xu C; Sun P; Wu J; Yan C; Hu M; Yan N, 2014, 'Crystal structure of the human glucose transporter GLUT1', Nature, 510, pp. 121 - 125
    Journal articles | 2014
    Deng D; Yan C; Wu J; Pan X; Yan N, 2014, 'Revisiting the TALE repeat', Protein Cell, 5, pp. 297 - 306
    Journal articles | 2014
    He Y; Hao Q; Li W; Yan C; Yan N; Yin P, 2014, 'Identification and characterization of ABA receptors in Oryza sativa', PLoS ONE, 9, pp. e95246 - e95246
    Journal articles | 2014
    He Y; Wang K; Yan N, 2014, 'The recombinant expression systems for structure determination of eukaryotic membrane proteins', Protein Cell, 5, pp. 658 - 672
    Journal articles | 2014
    Li Q; Yan C; Xu H; Wang Z; Long J; Li W; Wu J; Yin P; Yan N, 2014, 'Examination of the dimerization states of the single-stranded RNA recognition protein pentatricopeptide repeat 10 (PPR10)', J. Biol. Chem., 289, pp. 31503 - 31512
    Journal articles | 2014
    Madej MG; Sun L; Yan N; Kaback HR, 2014, 'Functional architecture of MFS D-glucose transporters', Proc. Natl. Acad. Sci. U.S.A., 111, pp. E719 - 727
    Journal articles | 2014
    Wang J; Yan C; Li Y; Hirata K; Yamamoto M; Yan N; Hu Q, 2014, 'Crystal structure of a bacterial homologue of SWEET transporters', Cell Res., 24, pp. 1486 - 1489
    Journal articles | 2013
    Li W; Wang L; Sheng X; Yan C; Zhou R; Hang J; Yin P; Yan N, 2013, 'Molecular basis for the selective and ABA-independent inhibition of PP2CA by PYL13', Cell Res., 23, pp. 1369 - 1379
    Journal articles | 2013
    Madej MG; Dang S; Yan N; Kaback HR, 2013, 'Evolutionary mix-and-match with MFS transporters', Proc. Natl. Acad. Sci. U.S.A., 110, pp. 5870 - 5874
    Journal articles | 2013
    Xia M; Liu H; Li Y; Yan N; Gong H, 2013, 'The mechanism of Na⁺/K⁺ selectivity in mammalian voltage-gated sodium channels based on molecular dynamics simulation', Biophys. J., 104, pp. 2401 - 2409
    Journal articles | 2013
    Yan N, 2013, 'Structural advances for the major facilitator superfamily (MFS) transporters', Trends Biochem. Sci., 38, pp. 151 - 159
    Journal articles | 2013
    Yan N, 2013, 'Structural investigation of the proton-coupled secondary transporters', Curr. Opin. Struct. Biol., 23, pp. 483 - 491
    Journal articles | 2013
    Yin P; Li Q; Yan C; Liu Y; Liu J; Yu F; Wang Z; Long J; He J; Wang HW; Wang J; Zhu JK; Shi Y; Yan N, 2013, 'Structural basis for the modular recognition of single-stranded RNA by PPR proteins', Nature, 504, pp. 168 - 171
    Journal articles | 2013
    Zhang X; Xia M; Li Y; Liu H; Jiang X; Ren W; Wu J; DeCaen P; Yu F; Huang S; He J; Clapham DE; Yan N; Gong H, 2013, 'Analysis of the selectivity filter of the voltage-gated sodium channel Na(v)Rh', Cell Res., 23, pp. 409 - 422, http://dx.doi.org/10.1038/cr.2012.173
    Journal articles | 2013
    Zhang X; Yan N, 2013, 'The conformational shifts of the voltage sensing domains between Na(v)Rh and Na(v)Ab', Cell Res., 23, pp. 444 - 447
    Journal articles | 2012
    Deng D; Yan C; Pan X; Mahfouz M; Wang J; Zhu JK; Shi Y; Yan N, 2012, 'Structural basis for sequence-specific recognition of DNA by TAL effectors', Science, 335, pp. 720 - 723
    Journal articles | 2012
    Deng D; Yin P; Yan C; Pan X; Gong X; Qi S; Xie T; Mahfouz M; Zhu JK; Yan N; Shi Y, 2012, 'Recognition of methylated DNA by TAL effectors', Cell Res., 22, pp. 1502 - 1504
    Journal articles | 2012
    Sugihara J; Sun L; Yan N; Kaback HR, 2012, 'Dynamics of the L-fucose/H+ symporter revealed by fluorescence spectroscopy', Proc. Natl. Acad. Sci. U.S.A., 109, pp. 14847 - 14851
    Journal articles | 2012
    Sun L; Zeng X; Yan C; Sun X; Gong X; Rao Y; Yan N, 2012, 'Crystal structure of a bacterial homologue of glucose transporters GLUT1-4', Nature, 490, pp. 361 - 366
    Journal articles | 2012
    Xie T; Ren R; Zhang YY; Pang Y; Yan C; Gong X; He Y; Li W; Miao D; Hao Q; Deng H; Wang Z; Wu JW; Yan N, 2012, 'Molecular mechanism for inhibition of a critical component in the Arabidopsis thaliana abscisic acid signal transduction pathways, SnRK2.6, by protein phosphatase ABI1', J. Biol. Chem., 287, pp. 794 - 802
    Journal articles | 2012
    Yin P; Deng D; Yan C; Pan X; Xi JJ; Yan N; Shi Y, 2012, 'Specific DNA-RNA hybrid recognition by TAL effectors', Cell Rep, 2, pp. 707 - 713
    Journal articles | 2012
    Zhang X; Ren W; DeCaen P; Yan C; Tao X; Tang L; Wang J; Hasegawa K; Kumasaka T; He J; Wang J; Clapham DE; Yan N, 2012, 'Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel', Nature, 486, pp. 130 - 134
    Journal articles | 2011
    Hao Q; Yin P; Li W; Wang L; Yan C; Lin Z; Wu JZ; Wang J; Yan SF; Yan N, 2011, 'The molecular basis of ABA-independent inhibition of PP2Cs by a subclass of PYL proteins', Mol. Cell, 42, pp. 662 - 672
    Journal articles | 2011
    He W; Brumos J; Li H; Ji Y; Ke M; Gong X; Zeng Q; Li W; Zhang X; An F; Wen X; Li P; Chu J; Sun X; Yan C; Yan N; Xie DY; Raikhel N; Yang Z; Stepanova AN; Alonso JM; Guo H, 2011, 'A small-molecule screen identifies L-kynurenine as a competitive inhibitor of TAA1/TAR activity in ethylene-directed auxin biosynthesis and root growth in Arabidopsis', Plant Cell, 23, pp. 3944 - 3960
    Journal articles | 2011
    Lu F; Li S; Jiang Y; Jiang J; Fan H; Lu G; Deng D; Dang S; Zhang X; Wang J; Yan N, 2011, 'Structure and mechanism of the uracil transporter UraA', Nature, 472, pp. 243 - 246
    Journal articles | 2010
    Dang S; Sun L; Huang Y; Lu F; Liu Y; Gong H; Wang J; Yan N, 2010, 'Structure of a fucose transporter in an outward-open conformation', Nature, 467, pp. 734 - 738
    Journal articles | 2010
    Hao Q; Yin P; Yan C; Yuan X; Li W; Zhang Z; Liu L; Wang J; Yan N, 2010, 'Functional mechanism of the abscisic acid agonist pyrabactin', J. Biol. Chem., 285, pp. 28946 - 28952
    Journal articles | 2010
    Qi S; Pang Y; Hu Q; Liu Q; Li H; Zhou Y; He T; Liang Q; Liu Y; Yuan X; Luo G; Li H; Wang J; Yan N; Shi Y, 2010, 'Crystal structure of the Caenorhabditis elegans apoptosome reveals an octameric assembly of CED-4', Cell, 141, pp. 446 - 457
    Journal articles | 2010
    Yuan X; Yin P; Hao Q; Yan C; Wang J; Yan N, 2010, 'Single amino acid alteration between valine and isoleucine determines the distinct pyrabactin selectivity by PYL1 and PYL2', J. Biol. Chem., 285, pp. 28953 - 28958
    Journal articles | 2009
    Geng X; Zhou QH; Kage-Nakadai E; Shi Y; Yan N; Mitani S; Xue D, 2009, 'Caenorhabditis elegans caspase homolog CSP-2 inhibits CED-3 autoactivation and apoptosis in germ cells', Cell Death and Differentiation, 16, pp. 1385 - 1394, http://dx.doi.org/10.1038/cdd.2009.88
    Journal articles | 2009
    Wang Y; Huang Y; Wang J; Cheng C; Huang W; Lu P; Xu YN; Wang P; Yan N; Shi Y, 2009, 'Structure of the formate transporter FocA reveals a pentameric aquaporin-like channel', Nature, 462, pp. 467 - 472
    Journal articles | 2009
    Yin P; Fan H; Hao Q; Yuan X; Wu D; Pang Y; Yan C; Li W; Wang J; Yan N, 2009, 'Structural insights into the mechanism of abscisic acid signaling by PYL proteins', Nat. Struct. Mol. Biol., 16, pp. 1230 - 1236
    Journal articles | 2007
    Feng L; Yan H; Wu Z; Yan N; Wang Z; Jeffrey PD; Shi Y, 2007, 'Structure of a site-2 protease family intramembrane metalloprotease', Science, 318, pp. 1608 - 1612
    Journal articles | 2007
    Yan N; Shi Y, 2007, 'Allosteric activation of a bacterial stress sensor', Cell, 131, pp. 441 - 443
    Journal articles | 2006
    Wu Z; Yan N; Feng L; Oberstein A; Yan H; Baker RP; Gu L; Jeffrey PD; Urban S; Shi Y, 2006, 'Structural analysis of a rhomboid family intramembrane protease reveals a gating mechanism for substrate entry', Nat. Struct. Mol. Biol., 13, pp. 1084 - 1091
    Journal articles | 2006
    Yan N; Huh JR; Schirf V; Demeler B; Hay BA; Shi Y, 2006, 'Structure and activation mechanism of the Drosophila initiator caspase Dronc', J. Biol. Chem., 281, pp. 8667 - 8674
    Journal articles | 2006
    Yan N; Xu Y; Shi Y, 2006, '2:1 Stoichiometry of the CED-4-CED-9 complex and the tetrameric CED-4: insights into the regulation of CED-3 activation', Cell Cycle, 5, pp. 31 - 34
    Journal articles | 2006
    Yang C; Yan N; Parish J; Wang X; Shi Y; Xue D, 2006, 'RNA aptamers targeting the cell death inhibitor CED-9 induce cell killing in Caenorhabditis elegans', J. Biol. Chem., 281, pp. 9137 - 9144
    Journal articles | 2005
    Yan N; Chai J; Lee ES; Gu L; Liu Q; He J; Wu JW; Kokel D; Li H; Hao Q; Xue D; Shi Y, 2005, 'Structure of the CED-4-CED-9 complex provides insights into programmed cell death in Caenorhabditis elegans', Nature, 437, pp. 831 - 837
    Journal articles | 2005
    Yan N; Shi Y, 2005, 'Mechanisms of apoptosis through structural biology', Annu. Rev. Cell Dev. Biol., 21, pp. 35 - 56
    Journal articles | 2004
    Feng L; Gell DA; Zhou S; Gu L; Kong Y; Li J; Hu M; Yan N; Lee C; Rich AM; Armstrong RS; Lay PA; Gow AJ; Weiss MJ; Mackay JP; Shi Y, 2004, 'Molecular mechanism of AHSP-mediated stabilization of alpha-hemoglobin', Cell, 119, pp. 629 - 640, http://dx.doi.org/10.1016/j.cell.2004.11.025
    Journal articles | 2004
    Huh JR; Vernooy SY; Yu H; Yan N; Shi Y; Guo M; Hay BA, 2004, 'Multiple apoptotic caspase cascades are required in nonapoptotic roles for Drosophila spermatid individualization', PLoS Biol., 2, pp. E15 - E15
    Journal articles | 2004
    La P; Silva AC; Hou Z; Wang H; Schnepp RW; Yan N; Shi Y; Hua X, 2004, 'Direct binding of DNA by tumor suppressor menin', J. Biol. Chem., 279, pp. 49045 - 49054
    Journal articles | 2004
    Shiozaki EN; Gu L; Yan N; Shi Y, 2004, 'Structure of the BRCT repeats of BRCA1 bound to a BACH1 phosphopeptide: implications for signaling', Mol. Cell, 14, pp. 405 - 412
    Journal articles | 2004
    Yan N; Gu L; Kokel D; Chai J; Li W; Han A; Chen L; Xue D; Shi Y, 2004, 'Structural, biochemical, and functional analyses of CED-9 recognition by the proapoptotic proteins EGL-1 and CED-4', Mol. Cell, 15, pp. 999 - 1006
    Journal articles | 2004
    Yan N; Wu JW; Chai J; Li W; Shi Y, 2004, 'Molecular mechanisms of DrICE inhibition by DIAP1 and removal of inhibition by Reaper, Hid and Grim', Nat. Struct. Mol. Biol., 11, pp. 420 - 428
    Journal articles | 2003
    Chai J; Wu JW; Yan N; Massagu? J; Pavletich NP; Shi Y, 2003, 'Features of a Smad3 MH1-DNA complex. Roles of water and zinc in DNA binding', J. Biol. Chem., 278, pp. 20327 - 20331
    Journal articles | 2003
    Chai J; Yan N; Huh JR; Wu JW; Li W; Hay BA; Shi Y, 2003, 'Molecular mechanism of Reaper-Grim-Hid-mediated suppression of DIAP1-dependent Dronc ubiquitination', Nat. Struct. Biol., 10, pp. 892 - 898
    Journal articles | 2003
    Yan N; Shi Y, 2003, 'Histone H1.2 as a trigger for apoptosis', Nat. Struct. Biol., 10, pp. 983 - 985
    Journal articles |
    Bai XC; Yan Z; Wu J; Li Z; Yan N, 'The Central domain of RyR1 is the transducer for long-range allosteric gating of channel opening', Cell Res., 26, pp. 995 - 1006
    Journal articles |
    Chi X; Gong D; Ren K; Zhou G; Huang G; Lei J; Zhou Q; Yan N, 'Molecular basis for allosteric regulation of the type 2 ryanodine receptor channel gating by key modulators', Proc. Natl. Acad. Sci. U.S.A., 116, pp. 25575 - 25582
    Journal articles |
    Gong D; Chi X; Ren K; Huang G; Zhou G; Yan N; Lei J; Zhou Q, 'Structure of the human plasma membrane Ca2+-ATPase 1 in complex with its obligatory subunit neuroplastin', Nat Commun, 9, pp. 3623 - 3623
    Journal articles |
    Gong D; Chi X; Wei J; Zhou G; Huang G; Zhang L; Wang R; Lei J; Chen SRW; Yan N, 'Modulation of cardiac ryanodine receptor 2 by calmodulin', Nature, 572, pp. 347 - 351
    Journal articles |
    Gong X; Qian H; Cao P; Zhao X; Zhou Q; Lei J; Yan N, 'Structural basis for the recognition of Sonic Hedgehog by human Patched1', Science, 361
    Journal articles |
    Han Y; Fan X; Wang H; Zhao F; Tully CG; Kong J; Yao N; Yan N, 'High-yield monolayer graphene grids for near-atomic resolution cryoelectron microscopy', Proc. Natl. Acad. Sci. U.S.A., 117, pp. 1009 - 1014
    Journal articles |
    Huang W; Liu M; Yan SF; Yan N, 'Structure-based assessment of disease-related mutations in human voltage-gated sodium channels', Protein Cell, 8, pp. 401 - 438
    Journal articles |
    Liu Y; Hu H; Wang J; Zhou Q; Wu P; Yan N; Wang HW; Wu JW; Sun L, 'Cryo-EM structure of L-fucokinase/GDP-fucose pyrophosphorylase (FKP) in Bacteroides fragilis', Protein Cell, 10, pp. 365 - 369
    Journal articles |
    Pan X; Li Z; Huang X; Huang G; Gao S; Shen H; Liu L; Lei J; Yan N, 'Molecular basis for pore blockade of human Na+ channel Nav1.2 by the μ-conotoxin KIIIA', Science, 363, pp. 1309 - 1313
    Journal articles |
    Pan X; Li Z; Zhou Q; Shen H; Wu K; Huang X; Chen J; Zhang J; Zhu X; Lei J; Xiong W; Gong H; Xiao B; Yan N, 'Structure of the human voltage-gated sodium channel Nav1.4 in complex with β1', Science, 362
    Journal articles |
    Peng W; Shen H; Wu J; Guo W; Pan X; Wang R; Chen SR; Yan N, 'Structural basis for the gating mechanism of the type 2 ryanodine receptor RyR2', Science, 354
    Journal articles |
    Qian H; Cao P; Hu M; Gao S; Yan N; Gong X, 'Inhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm', Nat Commun, 10, pp. 2320 - 2320
    Journal articles |
    Shen H; Zhou Q; Pan X; Li Z; Wu J; Yan N, 'Structure of a eukaryotic voltage-gated sodium channel at near-atomic resolution', Science, 355
    Journal articles |
    Wu J; Yan Z; Li Z; Qian X; Lu S; Dong M; Zhou Q; Yan N, 'Structure of the voltage-gated calcium channel Ca(v)1.1 at 3.6 Ã… resolution', Nature, 537, pp. 191 - 196
    Journal articles |
    Yan N, 'A Glimpse of Membrane Transport through Structures-Advances in the Structural Biology of the GLUT Glucose Transporters', J. Mol. Biol., 429, pp. 2710 - 2725
    Journal articles |
    Zhang J; Mao W; Ren Y; Sun RN; Yan N; Gong H, 'Simulating the ion permeation and ion selection for a eukaryotic voltage-gated sodium channel NaVPaS', Protein Cell, 9, pp. 580 - 585
    Journal articles |
    Zhao Y; Huang G; Wu J; Wu Q; Gao S; Yan Z; Lei J; Yan N, 'Molecular Basis for Ligand Modulation of a Mammalian Voltage-Gated Ca2+ Channel', Cell, 177, pp. 1495 - 1506
    Journal articles |
    Zhao Y; Huang G; Wu Q; Wu K; Li R; Lei J; Pan X; Yan N, 'Cryo-EM structures of apo and antagonist-bound human Cav3.1', Nature, 576, pp. 492 - 497