Dr Nona Farbehi

Dr Nona Farbehi

Jul 2020 – Sep 2022                      Post-doctoral Fellow

                                                       Prof. Powell's lab, GWCCG, Garvan Institute, Sydney, Australia

Mar 2014 – Jul 2018                      Doctor of Philosophy (Biomedical Engineering)

                                                       Graduate School of Biomedical Engineering (GSBME), UNSW and VCCRI, Sydney, Australia                              

Feb 2009 – May 2011                    Master of Science in Biomedical Engineering 

                                                       Amir Kabir University of Technology, Tehran, Iran                                                          

Sep 2004 – Feb 2009                    Bachelor of Science in Biomedical Engineering (First Class Honours)

                                                       Research and science branch of Islamic Azad University, Tehran, Iran        

Grad Sch: Biomedical Eng

Dr Nona Farbehi is a lecturer at the Graduate School of Biomedical Engineering and an honorary visiting scientist at the Garvan Institute. She completed her doctoral degree in Prof Richard Harvey’s lab at the Victor Chang Cardiac Research Institute and Prof Robert Nordon’s lab at UNSW, supported by IPRS Scholarship and Stem Cells Australia (SCA). After finishing her PhD, she was involved in establishing a state-of-the-art single-cell genomic centre, the so-called Garvan Weisman Centre for Cellular Genomic (GWCCG), to provide single-cell multi-omic platforms to all scientists nationally and internationally. She started her post-doc career in Prof Joseph Powell’s group in 2020, focusing on population-scale stem cell technology to understand how common DNA variation shapes cellular phenotypes before joining UNSW in 2022. Her interdisciplinary field of research involved using large-scale single-cell transcriptomic analysis of various cell types in health and disease and applying different technologies and bioinformatics tools, and designing and fabricating novel biomaterials and microfluidics systems.

BABS, E26 Level 1 UNSW Sydney NSW 2052 AUSTRALIA
  • Journal articles | 2022
    2022, 'Hif-1a suppresses ROS-induced proliferation of cardiac fibroblasts following myocardial infarction', Cell Stem Cell, 29, pp. 281 - 297.e12, http://dx.doi.org/10.1016/j.stem.2021.10.009
    Journal articles | 2022
    2022, 'Mimicry of embryonic circulation enhances the hoxa hemogenic niche and human blood development', Cell Reports, 40, pp. 111339, http://dx.doi.org/10.1016/j.celrep.2022.111339
    Journal articles | 2022
    2022, 'Retinal ganglion cell-specific genetic regulation in primary open-angle glaucoma', Cell Genomics, 2, pp. 100142 - 100142, http://dx.doi.org/10.1016/j.xgen.2022.100142
    Journal articles | 2022
    2022, 'Transcriptomic and proteomic retinal pigment epithelium signatures of age-related macular degeneration', Nature Communications, 13, http://dx.doi.org/10.1038/s41467-022-31707-4
    Journal articles | 2021
    Farbehi N; Janbandhu V; Nordon RE; Harvey RP, 2021, 'Facs enrichment of total interstitial cells and fibroblasts from adult mouse ventricles', Bio-protocol, 11, http://dx.doi.org/10.21769/BioProtoc.4028
    Journal articles | 2021
    Kalra K; Eberhard J; Farbehi N; Chong JJ; Xaymardan M, 2021, 'Role of PDGF-A/B Ligands in Cardiac Repair After Myocardial Infarction', Frontiers in Cell and Developmental Biology, 9, pp. 669188, http://dx.doi.org/10.3389/fcell.2021.669188
    Journal articles | 2021
    Valdés-Mora F; Salomon R; Gloss BS; Law AMK; Venhuizen J; Castillo L; Murphy KJ; Magenau A; Papanicolaou M; Rodriguez de la Fuente L; Roden DL; Colino-Sanguino Y; Kikhtyak Z; Farbehi N; Conway JRW; Sikta N; Oakes SR; Cox TR; O'Donoghue SI; Timpson P; Ormandy CJ; Gallego-Ortega D, 2021, 'Single-cell transcriptomics reveals involution mimicry during the specification of the basal breast cancer subtype', Cell Reports, 35, http://dx.doi.org/10.1016/j.celrep.2021.108945
    Journal articles | 2019
    Valdes-Mora F; Salomon R; Gloss B; Law AMK; Castillo L; Murphy K; Venhuizen J; Magenau A; Papanicolau M; de la Fuente LR; Roden D; Colino-Sanguino Y; Kikhtyak Z; Farbehi N; Conway JRW; Oakes S; Sikta N; O’Donoghue S; Cox T; Timpson P; Ormandy C; Gallego-Ortega D, 2019, 'Single cell transcriptomics reveals involution mimicry during the specification of the basal breast cancer subtype', , http://dx.doi.org/10.1101/624890
    Journal articles | 2019
    2019, 'Characterisation of developmental pathways that drive metastatic progression of breast cancer at single cell resolution', Oncology Abstracts, http://dx.doi.org/10.1530/oncolabs.1.p022
    Journal articles | 2019
    2019, 'Droplet-based single cell RNAseq tools: A practical guide', Lab on a Chip, 19, pp. 1706 - 1727, http://dx.doi.org/10.1039/c8lc01239c
    Journal articles | 2019
    2019, 'Single-cell expression profiling reveals dynamic flux of cardiac stromal, vascular and immune cells in health and injury', eLife, 8, http://dx.doi.org/10.7554/eLife.43882
    Journal articles | 2018
    2018, 'Large-scale, single cell RNA sequencing defines novel cellular subsets required for cardiac repair', Cytotherapy, 20, pp. S14 - S14, http://dx.doi.org/10.1016/j.jcyt.2018.02.024
    Journal articles | 2017
    2017, 'PDGFRα signaling in cardiac fibroblasts modulates quiescence, metabolism and self-renewal, and promotes anatomical and functional repair', , http://dx.doi.org/10.1101/225979
    Journal articles | 2016
    Hassanzadeh-Barforoushi A; Shemesh J; Farbehi N; Asadnia M; Yeoh GH; Harvey RP; Nordon RE; Warkiani ME, 2016, 'A rapid co-culture stamping device for studying intercellular communication', Scientific Reports, 6, http://dx.doi.org/10.1038/srep35618
  • Preprints | 2021
    2021, Retinal ganglion cell-specific genetic regulation in primary open angle glaucoma, , http://dx.doi.org/10.1101/2021.07.14.452417
    Preprints | 2021
    2021, Transcriptomic and proteomic retinal pigment epithelium signatures of age-related macular degeneration, , http://dx.doi.org/10.1101/2021.08.19.457044
    Conference Abstracts | 2018
    Farbehi N; Patrick R; Xaymardan M; Harvey R; Nordon R, 2018, 'LARGE-SCALE, SINGLE CELL RNA SEQUENCING DEFINES NOVEL CELLULAR SUBSETS REQUIRED FOR CARDIAC REPAIR', in CYTOTHERAPY, ELSEVIER SCI LTD, Vol. 20, pp. S14 - S14, http://dx.doi.org/10.1016/j.jcyt.2018.02.024
    Conference Abstracts | 2017
    Farbehi N; Patrick R; Xaymardan M; Harvey RP; Nordon R, 2017, 'HIGH THROUGHPUT SINGLE-CELL MRNA SEQUENCING REVEALS CELLULAR HETEROGENEITY IN CARDIAC MSCS AFTER MYOCARDIAL INFARCTION (MI)', in JOURNAL OF GENE MEDICINE, WILEY, AUSTRALIA, Univ Technol Sydney, Sydney, Vol. 20, presented at Joint 10th Annual Scientific Meeting of the Australian-Gene-and-Cell-Therapy-Society (AGCTS) and Australasian-Society-for-Stem-Cell-Research (ASSCR), AUSTRALIA, Univ Technol Sydney, Sydney, 24 May 2017 - 26 May 2017, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000426528300056&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2016
    2016, 'A RAPID MICROFLUIDIC STAMPING DEVICE FOR STUDYING CARDIAC STEM CELLS AND ENDOTHELIAL CELLS CO-CULTURE', in Proceedings MicroTAS 2016, Dublin, Republic of Ireland, pp. 1069 - 1070, presented at The 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016), Dublin, Republic of Ireland, 09 October 2016 - 13 October 2016
    Preprints |
    Single Cell Transcriptomics Reveals Involution Mimicry During the Specification of the Basal Breast Cancer Subtype, , http://dx.doi.org/10.2139/ssrn.3634808

Associate investigator in NHMRC ID2000615, ‘Crossing a frontier in cardiac fibrosis: a single-cell multiomics approach to understanding fibroblast agency in models of heart’, 2020

  • University of New South Wales International Postgraduate Research Scholarship, Sydney, Australia, 2014-2017.
  • ASSCR & NSCFA travel award, Lorne, Australia, 2014
  • ASSCR & NSCFA travel award, Hunter Valley, Australia, 2015
  • UNSW Student Travel Scholarship, Keystone Conference, Snowbird, USA, 2016
  • The 17th Victor Chang International Symposium, best PhD poster award-Third place, Sydney, Australia, 2016
  • ASSCR meeting, student travel award, Pert, Australia, 2016
  • Stem Cells Australia (SCA) Retreat, best poster prize and free registration of ASSCR 2018, Gold Coast, Australia, 2017.
  • 25th St Vincent’s Research Symposium, The runner-up poster prize, Sydney, Australia, 2017
  • ASSCR/AGCTS annual meeting, student travel award, Sydney, Australia, 2017
  • Sydney Cardiovascular Symposium, best poster prize (& flash talk), Sydney, Australia, 2017
  • ASSCR & NSCFA, travel award, Melbourne, Australia, 2018.
  • Nominated for Malcolm Chaikin Prize as the best PhD thesis in Biomedical engineering graduate research school at UNSW, 2018.
  • ASSCR/AGCTS annual meeting, travel award, Melbourne, Australia, 2022

  • Biomedical Engineering

  • Regenerative Medicine (Stem Cells and Tissue Engineering)

  • Microfluidic Devices

  • Cardiac disease

  • Single cell genomics

  • CRISPR interference and Perturb-seq

  • Biomaterials