Professor Paul De Souza

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Research Interests:
As a translational cancer researcher I am interested in applying sound biological and pharmacological principles to overcome the 'Valley of Death' in Drug Development. I focus on translating preclinical data into early Phase clinical trials of novel treatments, and discovering novel biomarkers (especially through liquid biopsy) that may help predict response or resistance to treatment: bench to bedside, and back to bench research. Individual cancers of interest include genitourinary, especially prostate, and brain tumours.

Broad Research Areas:
Cancer, Clinical Research, Cell Biology and Gene Regulation, Lipids, Pharmacology

Qualifications:
BScMed MB BS MPH Syd, PhD UNSW, FRACP

Society Memberships & Professional Activities:
ASCO, AACR, MOG, COSA

Specific Research Keywords:
Prostate Cancer, Brain Cancer, Cancer Drug Development and Pharmacology, Renal Cancer, Bladder Cancer

Phone

+61-2-85569300

Book Chapters | 2021

Po JW; Ma Y; Balakrishnar B; Brungs D; Azimi F; Cooper A; Saricilar E; Murthy V; de Souza P; Becker TM, 2021, 'PD-L1 Detection on Circulating Melanoma Cells', in Melanoma: Methods and Protocols, United States, pp. 223 - 233, http://dx.doi.org/10.1007/978-1-0716-1205-7_17

Book Chapters | 2021

Po JW; Ma Y; Luk AWS; Lynch D; Balakrishnar B; Brungs D; Azimi F; Cooper A; Saricilar E; Murthy V; de Souza P; Becker TM, 2021, 'Single-Cell Analysis of BRAF^V600E and NRAS^Q61R Mutation Status in Melanoma Cell Lines as Method Generation for Circulating Melanoma Cells', in Melanoma: Methods and Protocols, United States, pp. 277 - 286, http://dx.doi.org/10.1007/978-1-0716-1205-7_21
Journal articles | 2023

Gao B; Voskoboynik M; Cooper A; Wilkinson K; Hoon S; Hsieh CY; Cai S; Tian YE; Bao J; Ma N; Wang C; Zhang M; Li B; Guo M; Zhou R; Wang X; Xu C; de Souza P, 2023, 'A phase 1 dose-escalation study of the poly(ADP-ribose) polymerase inhibitor senaparib in Australian patients with advanced solid tumors', Cancer, http://dx.doi.org/10.1002/cncr.34662

Journal articles | 2022

Hnit SST; Yao M; Xie C; Bi L; Wong M; Liu T; De Souza P; Li Z; Dong Q, 2022, 'Apigenin impedes cell cycle progression at G2 phase in prostate cancer cells', Discover Oncology, vol. 13, http://dx.doi.org/10.1007/s12672-022-00505-1

Journal articles | 2022

Khan T; Becker TM; Scott KF; Descallar J; de Souza P; Chua W; Ma Y, 2022, 'Prognostic and Predictive Value of Liquid Biopsy-Derived Androgen Receptor Variant 7 (AR-V7) in Prostate Cancer: A Systematic Review and Meta-Analysis', Frontiers in Oncology, vol. 12, pp. 868031, http://dx.doi.org/10.3389/fonc.2022.868031

Journal articles | 2022

Khan T; Lock JG; Ma Y; Harman DG; de Souza P; Chua W; Balakrishnar B; Scott KF; Becker TM, 2022, 'Choice of antibody is critical for specific and sensitive detection of androgen receptor splice variant-7 in circulating tumor cells', Scientific Reports, vol. 12, pp. 16159, http://dx.doi.org/10.1038/s41598-022-20079-w

Journal articles | 2022

Lai HC; Ho UY; James A; De Souza P; Roberts TL, 2022, 'RNA metabolism and links to inflammatory regulation and disease', Cellular and Molecular Life Sciences, vol. 79, http://dx.doi.org/10.1007/s00018-021-04073-5

Journal articles | 2022

Rottey S; Clarke J; Aung K; Machiels JP; Markman B; Heinhuis KM; Millward M; Lolkema M; Patel SP; De Souza P; Duca M; Curigliano G; Santoro A; Koyama T; Brown M; Vezina H; He C; Siu-Chung Chu Q, 2022, 'Phase I/IIa Trial of BMS-986148, an Anti-mesothelin Antibody-drug Conjugate, Alone or in Combination with Nivolumab in Patients with Advanced Solid Tumors', Clinical Cancer Research, vol. 28, pp. 95 - 105, http://dx.doi.org/10.1158/1078-0432.CCR-21-1181

Journal articles | 2022

Sareen H; Ma Y; Becker TM; Roberts TL; de Souza P; Powter B, 2022, 'Molecular Biomarkers in Glioblastoma: A Systematic Review and Meta-Analysis', International journal of molecular sciences, vol. 23, http://dx.doi.org/10.3390/ijms23168835

Journal articles | 2021

Ardern-Holmes S; White C; Bahure S; So S; McCowage G; Hovey E; Troon S; De Souza P; Simes J; Slancar M; Dexter M; Wong M, 2021, 'The Effect of Bevacizumab on Vestibular Schwannoma Related to Neurofibromatosis Type 2', Australasian Journal of Neuroscience, vol. 31, pp. 5 - 14, http://dx.doi.org/10.21307/ajon-2021-002

Journal articles | 2021

Ding PN; Roberts TL; Chua W; Becker TM; Caixeiro N; de Souza P; Gao B; Lee CK; Itchins M; Westman H; Clarke S; Blinman P; Kao S; John T; Leal JL; Bray VJ, 2021, 'Plasma pre-treatment T790M relative allelic frequency in patients with advanced EGFR-mutated non-small cell lung cancer predicts treatment response to subsequent-line osimertinib', Translational Lung Cancer Research, vol. 10, pp. 1623 - 1634, http://dx.doi.org/10.21037/tlcr-20-1125

Journal articles | 2021

Garrett C; Becker TM; Lynch D; Po J; Xuan W; Scott KF; De Souza P, 2021, 'Comparison of neutrophil to lymphocyte ratio and prognostic nutritional index with other clinical and molecular biomarkers for prediction of glioblastoma multiforme outcome', PLoS ONE, vol. 16, http://dx.doi.org/10.1371/journal.pone.0252614

Journal articles | 2021

Lai HC; James A; Luff J; De Souza P; Quek H; Ho U; Lavin MF; Roberts TL, 2021, 'Regulation of RNA degradation pathways during the lipopolysaccharide response in Macrophages', Journal of Leukocyte Biology, vol. 109, pp. 593 - 603, http://dx.doi.org/10.1002/JLB.2AB0420-151RR

Journal articles | 2021

Piha-Paul SA; Thein KZ; De Souza P; Kefford R; Gangadhar T; Smith C; Schuster S; Zamboni WC; Dees CE; Markman B, 2021, 'First‐in‐human, phase I/IIa study of CRLX301, a nanoparticle drug conjugate containing docetaxel, in patients with advanced or metastatic solid malignancies', Investigational New Drugs, vol. 39, pp. 1047 - 1056, http://dx.doi.org/10.1007/s10637-021-01081-x

Journal articles | 2021

Powter B; Jeffreys SA; Sareen H; Cooper A; Brungs D; Po J; Roberts T; Koh ES; Scott KF; Sajinovic M; Vessey JY; de Souza P; Becker TM, 2021, 'Human TERT promoter mutations as a prognostic biomarker in glioma', Journal of Cancer Research and Clinical Oncology, vol. 147, pp. 1007 - 1017, http://dx.doi.org/10.1007/s00432-021-03536-3

Journal articles | 2021

Scott KF; Mann TJ; Fatima S; Sajinovic M; Razdan A; Kim RR; Cooper A; Roohullah A; Bryant KJ; Gamage KK; Harman DG; Vafaee F; Graham GG; Church WB; Russell PJ; Dong Q; de Souza P, 2021, 'Human group iia phospholipase A2 —three decades on from its discovery', Molecules, vol. 26, pp. 7267 - 7267, http://dx.doi.org/10.3390/molecules26237267

Journal articles | 2020

Ackland SP; Michael M; de Souza P; Martin JH; Clarke SJ; Francis K; Karapetis CS; Gurney H, 2020, 'Science and art of anticancer drug dosing: nine steps to personalised therapy', Internal Medicine Journal, vol. 50, pp. 992 - 996, http://dx.doi.org/10.1111/imj.14948

Journal articles | 2020

Aghajani MJ; Yang T; Schmitz U; James A; McCafferty CE; de Souza P; Niles N; Roberts TL, 2020, 'Epithelial-to-mesenchymal transition and its association with PD-L1 and CD8 in thyroid cancer', Endocrine Connections, vol. 9, pp. 1028 - 1041, http://dx.doi.org/10.1530/EC-20-0268

Journal articles | 2020

Bi L; Xie C; Jiao L; Jin S; Hnit SST; Mu Y; Wang Y; Wang Q; Ge G; Wang Y; Zhao X; Shi X; Kang Y; De Souza P; Liu T; Zhou J; Xu L; Dong Q, 2020, 'CPF impedes cell cycle re-entry of quiescent lung cancer cells through transcriptional suppression of FACT and c-MYC', Journal of Cellular and Molecular Medicine, vol. 24, pp. 2229 - 2239, http://dx.doi.org/10.1111/jcmm.14897

Journal articles | 2020

Broom A; Parker R; Raymond S; Kirby E; Lewis S; Kokanović R; Adams J; de Souza P; Woodland L; Wyld D; Lwin Z; Koh ES, 2020, 'The (Co)Production of Difference in the Care of Patients With Cancer From Migrant Backgrounds', Qualitative Health Research, vol. 30, pp. 1619 - 1631, http://dx.doi.org/10.1177/1049732320930699

Journal articles | 2020

Hnit SST; Yao M; Xie C; Ge G; Bi L; Jin S; Jiao L; Xu L; Long L; Nie H; Jin Y; Rogers L; Suchowerska N; Wong M; Liu T; De Souza P; Li Z; Dong Q, 2020, 'Transcriptional regulation of G2/M regulatory proteins and perturbation of G2/M Cell cycle transition by a traditional Chinese medicine recipe', Journal of Ethnopharmacology, vol. 251, http://dx.doi.org/10.1016/j.jep.2019.112526

Journal articles | 2020

Jeffreys SA; Powter B; Balakrishnar B; Mok K; Soon P; Franken A; Neubauer H; de Souza P; Becker TM, 2020, 'Endocrine Resistance in Breast Cancer: The Role of Estrogen Receptor Stability', Cells, vol. 9, http://dx.doi.org/10.3390/cells9092077

Journal articles | 2020

Kato H; de Souza P; Kim SW; Lickliter JD; Naito Y; Park K; Kumar S; Mugundu GM; Bang YJ, 2020, 'Safety, Pharmacokinetics, and Clinical Activity of Adavosertib in Combination with Chemotherapy in Asian Patients with Advanced Solid Tumors: Phase Ib Study', Targeted Oncology, vol. 15, pp. 75 - 84, http://dx.doi.org/10.1007/s11523-020-00701-5

Journal articles | 2020

Khan T; Scott KF; Becker TM; Lock J; Nimir M; Ma Y; De Souza P, 2020, 'The Prospect of Identifying Resistance Mechanisms for Castrate-Resistant Prostate Cancer Using Circulating Tumor Cells: Is Epithelial-to-Mesenchymal Transition a Key Player?', Prostate Cancer, vol. 2020, pp. 7938280, http://dx.doi.org/10.1155/2020/7938280

Journal articles | 2020

Lynch D; Powter B; Po JW; Cooper A; Garrett C; Koh ES; Sheridan M; van Gelder J; Darwish B; Mckechnie S; Bazina R; Jaeger M; Roberts TL; de Souza P; Becker TM, 2020, 'Isolation of circulating tumor cells from glioblastoma patients by direct immunomagnetic targeting', Applied Sciences (Switzerland), vol. 10, pp. 3338 - 3338, http://dx.doi.org/10.3390/app10093338

Journal articles | 2020

Reardon DA; Brandes AA; Omuro A; Mulholland P; Lim M; Wick A; Baehring J; Ahluwalia MS; Roth P; Bähr O; Phuphanich S; Sepulveda JM; De Souza P; Sahebjam S; Carleton M; Tatsuoka K; Taitt C; Zwirtes R; Sampson J; Weller M, 2020, 'Effect of Nivolumab vs Bevacizumab in Patients with Recurrent Glioblastoma: The CheckMate 143 Phase 3 Randomized Clinical Trial', JAMA Oncology, vol. 6, pp. 1003 - 1010, http://dx.doi.org/10.1001/jamaoncol.2020.1024

Journal articles | 2020

Sareen H; Garrett C; Lynch D; Powter B; Brungs D; Cooper A; Po J; Koh ES; Vessey JY; McKechnie S; Bazina R; Sheridan M; van Gelder J; Darwish B; Jaeger M; Roberts TL; De Souza P; Becker TM, 2020, 'The role of liquid biopsies in detecting molecular tumor biomarkers in brain cancer patients', Cancers, vol. 12, pp. 1 - 16, http://dx.doi.org/10.3390/cancers12071831

Journal articles | 2020

Tjokrowidjaja A; Goldstein D; Hudson HM; Lord SJ; Gebski V; Clarke S; de Souza P; Motzer RJ; Lee CK, 2020, 'The impact of neutrophil-lymphocyte ratio on risk reclassification of patients with advanced renal cell cancer to guide risk-directed therapy', Acta Oncologica, vol. 59, pp. 20 - 27, http://dx.doi.org/10.1080/0284186X.2019.1656342

Journal articles | 2020

Toh JWT; Lim SH; MacKenzie S; de Souza P; Bokey L; Chapuis P; Spring KJ, 2020, 'Association Between Microsatellite Instability Status and Peri-Operative Release of Circulating Tumour Cells in Colorectal Cancer', Cells, vol. 9, http://dx.doi.org/10.3390/cells9020425

Journal articles | 2020

Wimmer M; Zauner R; Ablinger M; Pinõ´ n-Hofbauer J; Guttmann-Gruber C; Reisenberger M; Lettner T; Niklas N; Proell J; Sajinovic M; De Souza P; Hainzl S; Kocher T; Murauer EM; Bauer JW; Strunk D; Reichelt J; Mellick AS; Wally V, 2020, 'A cancer stem cell-like phenotype is associated with miR-10b expression in aggressive squamous cell carcinomas', Cell Communication and Signaling, vol. 18, pp. 61, http://dx.doi.org/10.1186/s12964-020-00550-9

Journal articles | 2019

Aghajani MJ; Cooper A; McGuire H; Jeffries T; Saab J; Ismail K; de Souza P; Bray V; Fazekas de St Groth B; Niles N; Roberts TL, 2019, 'Pembrolizumab for anaplastic thyroid cancer: a case study', Cancer Immunology, Immunotherapy, vol. 68, pp. 1921 - 1934, http://dx.doi.org/10.1007/s00262-019-02416-7

Journal articles | 2019

Basch EM; Scholz M; de Bono JS; Vogelzang N; de Souza P; Marx G; Vaishampayan U; George S; Schwarz JK; Antonarakis ES; O'Sullivan JM; Kalebasty AR; Chi KN; Dreicer R; Hutson TE; Dueck AC; Bennett AV; Dayan E; Mangeshkar M; Holland J; Weitzman AL; Scher HI, 2019, 'Cabozantinib Versus Mitoxantrone-prednisone in Symptomatic Metastatic Castration-resistant Prostate Cancer: A Randomized Phase 3 Trial with a Primary Pain Endpoint', European Urology, vol. 75, pp. 929 - 937, http://dx.doi.org/10.1016/j.eururo.2018.11.033

Journal articles | 2019

Broom A; Kirby E; Kokonavic R; Woodland L; Wyld D; de Souza P; Koh S; Lwin Z, 2019, 'Individualising difference, negotiating culture: Intersections of biography and cancer care', Health, pp. 1363459319829192, http://dx.doi.org/10.1177/1363459319829192

Journal articles | 2019

Clingan PR; Ackland SP; Brungs D; de Souza P; Aghmesheh M; Garg MB; Ranson RD; Parker S; Jokela R; Ranson M, 2019, 'First-in-human phase I study of infusional and bolus schedules of Deflexifol, a novel 5-fluorouracil and leucovorin formulation, after failure of standard treatment', Asia-Pacific Journal of Clinical Oncology, vol. 15, pp. 151 - 157, http://dx.doi.org/10.1111/ajco.13144

Journal articles | 2019

Ding PN; Becker T; Bray V; Chua W; Ma Y; Xu B; Lynch D; de Souza P; Roberts T, 2019, 'Plasma next generation sequencing and droplet digital PCR-based detection of epidermal growth factor receptor (EGFR) mutations in patients with advanced lung cancer treated with subsequent-line osimertinib', Thoracic Cancer, vol. 10, pp. 1879 - 1884, http://dx.doi.org/10.1111/1759-7714.13154

Journal articles | 2019

Ding PN; Becker TM; Bray VJ; Chua W; Ma YF; Lynch D; Po J; Luk AWS; Caixeiro N; de Souza P; Roberts TL, 2019, 'The predictive and prognostic significance of liquid biopsy in advanced epidermal growth factor receptor-mutated non-small cell lung cancer: A prospective study', Lung Cancer, vol. 134, pp. 187 - 193, http://dx.doi.org/10.1016/j.lungcan.2019.06.021

Journal articles | 2019

Nimir M; Ma Y; Jeffreys SA; Opperman T; Young F; Khan T; Ding P; Chua W; Balakrishnar B; Cooper A; Souza PD; Becker TM, 2019, 'Detection of AR-v7 in liquid biopsies of castrate resistant prostate cancer patients: A comparison of AR-v7 analysis in circulating tumor cells, circulating tumor RNA and exosomes', Cells, vol. 8, http://dx.doi.org/10.3390/cells8070688

Journal articles | 2019

Panizza BJ; de Souza P; Cooper A; Roohullah A; Karapetis CS; Lickliter JD, 2019, 'Phase I dose-escalation study to determine the safety, tolerability, preliminary efficacy and pharmacokinetics of an intratumoral injection of tigilanol tiglate (EBC-46)', EBioMedicine, vol. 50, pp. 433 - 441, http://dx.doi.org/10.1016/j.ebiom.2019.11.037

Journal articles | 2019

Po JW; Ma Y; Balakrishna B; Brungs D; Azimi F; De Souza P; Becker TM, 2019, 'Immunomagnetic isolation of circulating melanoma cells and detection of PD-L1 status', PLoS ONE, vol. 14, pp. e0211866, http://dx.doi.org/10.1371/journal.pone.0211866

Journal articles | 2019

Powderly J; Spira A; Gutierrez R; DiRenzo D; Udyavar A; Karakunnel JJ; Rieger A; Colabella J; Lai DW; de Souza P, 2019, 'Phase I evaluation of AB928, a novel dual adenosine receptor antagonist, combined with chemotherapy or AB122 (anti-PD-1) in patients (pts) with advanced malignancies', Annals of Oncology, vol. 30, pp. v493 - v493, http://dx.doi.org/10.1093/annonc/mdz253.032

Journal articles | 2018

Bi L; Xie C; Yao M; Thae Hnit SS; Vignarajan S; Wang Y; Wang Q; Xi Z; Xu H; Li Z; de Souza P; Tee A; Wong M; Liu T; Zhao X; Zhou J; Xu L; Dong Q, 2018, 'The histone chaperone complex FACT promotes proliferative switch of G0 cancer cells', International Journal of Cancer, vol. 145, pp. 164 - 178, http://dx.doi.org/10.1002/ijc.32065

Journal articles | 2018

Ding PN; Ma YF; Roberts TJ; Chua W; Bray VJ; Lynch D; Burke D; Souza PD; Becker TM, 2018, 'Droplet Digital PCR Based Detection of EGFR Mutations in Advanced Lung Cancer Patient Liquid Biopsies: A Comparison of Circulating Tumour DNA Extraction Kits', Journal of Molecular Biomarkers & Diagnosis, vol. 09, http://dx.doi.org/10.4172/2155-9929.1000397

Journal articles | 2018

Harris BHL; Walsh JL; Neciunaite R; Manders P; Cooper A; De Souza P, 2018, 'Ring a ring o'roses, a patient with Kaposi's? Pazopanib, pazopanib, it might go away. Mediterranean (classic) Kaposi sarcoma responds to the tyrosine kinase inhibitor pazopanib after multiple lines of standard therapy', Clinical and Experimental Dermatology, vol. 43, pp. 234 - 236, http://dx.doi.org/10.1111/ced.13302

Journal articles | 2018

Po JW; Roohullah A; Lynch D; DeFazio A; Harrison M; Harnett PR; Kennedy C; de Souza P; Becker TM, 2018, 'Improved ovarian cancer EMT-CTC isolation by immunomagnetic targeting of epithelial EpCAM and mesenchymal N-cadherin', Journal of Circulating Biomarkers, vol. 7, http://dx.doi.org/10.1177/1849454418782617

Journal articles | 2018

Roohullah A; Cooper A; Lomax AJ; Aung J; Barge A; Chow L; McHale M; Desai J; Whittle JR; Tran B; de Souza P; Horvath LG, 2018, 'A phase I trial to determine safety and pharmacokinetics of ASLAN002, an oral MET superfamily kinase inhibitor, in patients with advanced or metastatic solid cancers', Investigational New Drugs, vol. 36, pp. 886 - 894, http://dx.doi.org/10.1007/s10637-018-0588-7

Journal articles | 2017

Callari M; De Souza PL; Rawal A; Stenzel MH, 2017, 'The Effect of Drug Loading on Micelle Properties: Solid-State NMR as a Tool to Gain Structural Insight', Angewandte Chemie - International Edition, vol. 56, pp. 8441 - 8445, http://dx.doi.org/10.1002/anie.201701471

Journal articles | 2017

Callari M; De Souza PL; Rawal A; Stenzel MH, 2017, 'The Effect of Drug Loading on Micelle Properties: Solid‐State NMR as a Tool to Gain Structural Insight', Angewandte Chemie, vol. 129, pp. 8561 - 8565, http://dx.doi.org/10.1002/ange.201701471

Journal articles | 2017

Callari M; Wong S; Lu H; Aldrich-Wright J; De Souza P; Stenzel MH, 2017, 'Drug induced self-assembly of triblock copolymers into polymersomes for the synergistic dual-drug delivery of platinum drugs and paclitaxel', Polymer Chemistry, vol. 8, pp. 6289 - 6299, http://dx.doi.org/10.1039/c7py01162h

Journal articles | 2017

Luk AWS; Ma Y; Ding PN; Young FP; Chua W; Balakrishnar B; Dransfield DT; De Souza P; Becker TM, 2017, 'CTC-mRNA (AR-V7) analysis from blood samples—impact of blood collection tube and storage time', International Journal of Molecular Sciences, vol. 18, http://dx.doi.org/10.3390/ijms18051047

Journal articles | 2016

Ho V; Chung L; Revoltar M; Lim SH; Tut TG; Abubakar A; Henderson CJ; Chua W; Ng W; Lee M; De Souza P; Morgan M; Lee CS; Shin JS, 2016, 'MRE11 and ATM expression levels predict rectal cancer survival and their association with radiotherapy response', PLoS ONE, vol. 11, http://dx.doi.org/10.1371/journal.pone.0167675

Journal articles | 2016

Toh JWT; de Souza P; Lim SH; Singh P; Chua W; Ng W; Spring KJ, 2016, 'The Potential Value of Immunotherapy in Colorectal Cancers: Review of the Evidence for Programmed Death-1 Inhibitor Therapy', Clinical Colorectal Cancer, vol. 15, pp. 285 - 291, http://dx.doi.org/10.1016/j.clcc.2016.07.007

Journal articles | 2015

Hnit SST; Xie C; Yao M; Holst J; Bensoussan A; De Souza P; Li Z; Dong Q, 2015, 'P27^Kip1 signaling: Transcriptional and post-translational regulation', International Journal of Biochemistry and Cell Biology, vol. 68, pp. 9 - 14, http://dx.doi.org/10.1016/j.biocel.2015.08.005

Journal articles | 2015

Lim SH; Chua W; Henderson C; Ng W; Shin JS; Chantrill L; Asghari R; Lee CS; Spring KJ; de Souza P, 2015, 'Predictive and prognostic biomarkers for neoadjuvant chemoradiotherapy in locally advanced rectal cancer', Critical Reviews in Oncology/Hematology, vol. 96, pp. 67 - 80, http://dx.doi.org/10.1016/j.critrevonc.2015.05.003

Journal articles | 2015

Lim SH; Spring KJ; De Souza P; Mackenzie S; Bokey L, 2015, 'Circulating tumour cells and circulating nucleic acids as a measure of tumour dissemination in non-metastatic colorectal cancer surgery', European Journal of Surgical Oncology, vol. 41, pp. 309 - 314, http://dx.doi.org/10.1016/j.ejso.2014.12.005

Journal articles | 2015

Ryan CJ; Smith MR; Fizazi K; Saad F; Mulders PFA; Sternberg CN; Miller K; Logothetis CJ; Shore ND; Small EJ; Carles J; Flaig TW; Taplin ME; Higano CS; de Souza P; de Bono JS; Griffin TW; De Porre P; Yu MK; Park YC; Li J; Kheoh T; Naini V; Molina A; Rathkopf DE, 2015, 'Abiraterone acetate plus prednisone versus placebo plus prednisone in chemotherapy-naive men with metastatic castration-resistant prostate cancer (COU-AA-302): Final overall survival analysis of a randomised, double-blind, placebo-controlled phase 3 study', The Lancet Oncology, vol. 16, pp. 152 - 160, http://dx.doi.org/10.1016/S1470-2045(14)71205-7

Journal articles | 2015

Scarano W; De Souza P; Stenzel MH, 2015, 'Dual-drug delivery of curcumin and platinum drugs in polymeric micelles enhances the synergistic effects: A double act for the treatment of multidrug-resistant cancer', Biomaterials Science, vol. 3, pp. 163 - 174, http://dx.doi.org/10.1039/c4bm00272e

Journal articles | 2015

Tognela A; Spring KJ; Becker T; Caixeiro NJ; Bray VJ; Yip PY; Chua W; Lim SH; de Souza P, 2015, 'Predictive and prognostic value of circulating tumor cell detection in lung cancer: A clinician's perspective', Critical Reviews in Oncology/Hematology, vol. 93, pp. 90 - 102, http://dx.doi.org/10.1016/j.critrevonc.2014.10.001

Journal articles | 2015

Tut TG; Lim SHS; Dissanayake IU; Descallar J; Chua W; Ng W; De Souza P; Shin JS; Lee CS, 2015, 'Upregulated polo-like kinase 1 expression correlates with inferior survival outcomes in rectal cancer', PLoS ONE, vol. 10, http://dx.doi.org/10.1371/journal.pone.0129313

Journal articles | 2014

Becker TM; Caixeiro NJ; Lim SH; Tognela A; Kienzle N; Scott KF; Spring KJ; De Souza P, 2014, 'New frontiers in circulating tumor cell analysis: A reference guide for biomolecular profiling toward translational clinical use', International Journal of Cancer, vol. 134, pp. 2523 - 2533, http://dx.doi.org/10.1002/ijc.28516

Journal articles | 2014

Caixeiro NJ; Kienzle N; Lim SH; Spring KJ; Tognela A; Scott KF; De Souza P; Becker TM, 2014, 'Circulating tumour cells - A bona fide cause of metastatic cancer', Cancer and Metastasis Reviews, vol. 33, pp. 747 - 756, http://dx.doi.org/10.1007/s10555-014-9502-8

Journal articles | 2014

Caixeiro NJ; Kienzle N; Lim SH; Spring KJ; Tognela A; Scott KF; de Souza P; Becker TM, 2014, 'Circulating tumour cells-a bona fide cause of metastatic cancer', Cancer and Metastasis Reviews, http://dx.doi.org/10.1007/s10555-014-9502-8

Journal articles | 2014

Callari M; Aldrich-Wright JR; De Souza PL; Stenzel MH, 2014, 'Polymers with platinum drugs and other macromolecular metal complexes for cancer treatment', Progress in Polymer Science, vol. 39, pp. 1614 - 1643, http://dx.doi.org/10.1016/j.progpolymsci.2014.05.002

Journal articles | 2014

Lim SH; Becker TM; Chua W; Caixeiro NJ; Ng WL; Kienzle N; Tognela A; Lumba S; Rasko JEJ; De Souza P; Spring KJ, 2014, 'Circulating tumour cells and circulating free nucleic acid as prognostic and predictive biomarkers in colorectal cancer', Cancer Letters, vol. 346, pp. 24 - 33, http://dx.doi.org/10.1016/j.canlet.2013.12.019

Journal articles | 2014

Lim SHS; Ardern-Holmes S; McCowage G; De Souza P, 2014, 'Systemic therapy in neurofibromatosis type 2', Cancer Treatment Reviews, vol. 40, pp. 857 - 861, http://dx.doi.org/10.1016/j.ctrv.2014.05.004

Journal articles | 2014

Lim SHS; Becker TM; Chua W; Ng WL; De Souza P; Spring KJ, 2014, 'Circulating tumour cells and the epithelial mesenchymal transition in colorectal cancer', Journal of Clinical Pathology, vol. 67, pp. 848 - 853, http://dx.doi.org/10.1136/jclinpath-2014-202499

Journal articles | 2014

Lim SHS; Chua W; Cheng C; Descallar J; Ng W; Solomon M; Bokey L; Wong K; Lee MT; De Souza P; Shin JS; Lee CS, 2014, 'Effect of neoadjuvant chemoradiation on tumor-infiltrating/associated lymphocytes in locally advanced rectal cancers', Anticancer Research, vol. 34, pp. 6505 - 6513

Journal articles | 2014

Mak G; Chin M; Nahar N; De Souza P, 2014, 'Cutaneous metastasis of prostate carcinoma treated with radiotherapy: A case presentation', BMC Research Notes, vol. 7, http://dx.doi.org/10.1186/1756-0500-7-505

Journal articles | 2014

Rathkopf DE; Smith MR; De Bono JS; Logothetis CJ; Shore ND; De Souza P; Fizazi K; Mulders PFA; Mainwaring P; Hainsworth JD; Beer TM; North S; Fradet Y; Van Poppel H; Carles J; Flaig TW; Efstathiou E; Yu EY; Higano CS; Taplin ME; Griffin TW; Todd MB; Yu MK; Park YC; Kheoh T; Small EJ; Scher HI; Molina A; Ryan CJ; Saad F, 2014, 'Updated interim efficacy analysis and long-term safety of abiraterone acetate in metastatic castration-resistant prostate cancer patients without prior chemotherapy (COU-AA-302)', European Urology, vol. 66, pp. 815 - 825, http://dx.doi.org/10.1016/j.eururo.2014.02.056

Journal articles | 2014

Tse BWC; Jovanovic L; Nelson CC; De Souza P; Power CA; Russell PJ, 2014, 'From Bench to Bedside: Immunotherapy for Prostate Cancer', BioMed Research International, vol. 2014, http://dx.doi.org/10.1155/2014/981434

Journal articles | 2013

Fox P; Hudson M; Brown C; Lord S; Gebski V; De Souza P; Lee CK, 2013, 'Markers of systemic inflammation predict survival in patients with advanced renal cell cancer', British Journal of Cancer, vol. 109, pp. 147 - 153, http://dx.doi.org/10.1038/bjc.2013.300

Journal articles | 2013

Motzer RJ; Hutson TE; Cella D; Reeves J; Hawkins R; Guo J; Nathan P; Staehler M; Souza P; Merchan JR; Boleti E; Fife K; Jin J; Jones R; Uemura H; De Giorgi U; Harmenberg U; Wang J; Sternberg CN; Deen K; McCann L; Hackshaw MD; Crescenzo R; Pandite LN; Choueiri TK, 2013, 'Pazopanib versus sunitinib in metastatic renal-cell carcinoma', New England Journal of Medicine, vol. 369, pp. 722 - 731, http://dx.doi.org/10.1056/NEJMoa1303989

Journal articles | 2013

Paz-Ares L; Bálint B; De Boer RH; Van Meerbeeck JP; Wierzbicki R; De Souza P; Galimi F; Haddad V; Sabin T; Hei YJ; Pan Y; Cottrell S; Hsu CP; Ramlau R, 2013, 'A randomized phase 2 study of paclitaxel and carboplatin with or without conatumumab for first-line treatment of advanced non-small-cell lung cancer', Journal of Thoracic Oncology, vol. 8, pp. 329 - 337, http://dx.doi.org/10.1097/JTO.0b013e31827ce554

Journal articles | 2013

Ryan C; Smith M; de Bono J; Molina A; Logothetis D; De Souza P; et A, 2013, 'Abiraterone in metastatic prostate cancer without previous chemotherapy', New England Journal of Medicine, vol. 368, pp. 138 - 148, http://dx.doi.org/10.1056/NEJMoa1209096

Journal articles | 2013

Scarano W; Duong HTT; Lu HX; De Souza PL; Stenzel MH, 2013, 'Folate Conjugation to Polymeric Micelles via Boronic Acid Ester to Deliver Platinum Drugs to Ovarian Cancer Cell Lines', Biomacromolecules, vol. 14, pp. 962 - 975, http://dx.doi.org/10.1021/bm400121q

Journal articles | 2013

Weber MF; Smith DP; O'Connell DL; Patel MI; de Souza PL; Sitas F; Banks E, 2013, 'Risk factors for erectile dysfunction in a cohort of 108 477. Australian men', Medical Journal of Australia, vol. 199, pp. 107 - 111, http://dx.doi.org/10.5694/mja12.11548

Journal articles | 2013

Won ACM; Gurney H; Marx G; De Souza P; Patel MI, 2013, 'Primary treatment of the prostate improves local palliation in men who ultimately develop castrate-resistant prostate cancer', BJU International, vol. 112, http://dx.doi.org/10.1111/bju.12169

Journal articles | 2012

Boyer M; Horwood K; Pavlakis N; De Souza P; Millward MJ; Stein B; Johnston M; Abell F; Rischin D, 2012, 'Efficacy of erlotinib in patients with advanced Non-small-cell Lung Cancer (NSCLC): Analysis of the Australian subpopulation of the TRUST study.', Asia-Pacific Journal of Clinical Oncology, vol. 8, pp. 248 - 254, http://dx.doi.org/10.1111/j.1743-7563.2012.01540.x

Journal articles | 2012

Goldstein D; Bennett BK; Webber K; Boyle F; De Souza P; Wilcken NRC; Scott E; Toppler R; Murie P; O''Malley L; Mccourt J; Friedlander M; Hickie IB; Lloyd AR, 2012, 'Cancer-related fatigue in women with breast cancer: outcomes of a 5 year prospective cohort study.', Journal of Clinical Oncology, vol. 30, pp. 1805 - 1812, http://dx.doi.org/10.1200/JCO.2011.34.6148

Journal articles | 2012

Huynh VT; Binauld SDM; De souza P; Stenzel MH, 2012, 'Acid Degradable Cross-Linked Micelles for the Delivery of Cisplatin: A Comparison with Nondegradable Cross-Linker', Chemistry of materials, vol. 24, pp. 3197 - 3211, http://dx.doi.org/10.1021/cm301556b

Journal articles | 2012

Huynh VT; Quek JY; De Souza P; Stenzel MH, 2012, 'Block copolymer micelles with pendant bifunctional chelator for platinum drugs: Effect of spacer length on the viability of tumor cells', Biomacromolecules, vol. 13, pp. 1010 - 1023, http://dx.doi.org/10.1021/bm2017299

Journal articles | 2012

Lee CK; Marschner IC; Simes RJ; Voysey M; Egleston B; Hudes G; De Souza P, 2012, 'Increase in cholesterol predicts survival advantage in renal cell carcinoma patients treated with temsirolimus', Clinical Cancer Research, vol. 18, pp. 3188 - 3196, http://dx.doi.org/10.1158/1078-0432.CCR-11-3137

Journal articles | 2012

Xu C; Xue Z; Bing NX; King K; De Souza P; et A, 2012, 'Concomitant use of pazopanib and simvastatin increases the risk of transaminase elevations in patients with cancer', Annals of Oncology, vol. 23 Sep 2012, pp. 2470 - 2471, http://dx.doi.org/10.1093/annonc/mds249

Journal articles | 2011

Gu W; Gaborieau M; Huynh VT; De Souza PL; Stenzel MH, 2011, 'Functionalization of microspheres with malonates using Michael Addition as a pathway to create a drug delivery system for platinum drugs for the treatment of liver cancer', Polymer, vol. 52, pp. 5993 - 6002, http://dx.doi.org/10.1016/j.polymer.2011.10.054

Journal articles | 2011

Huynh VT; De Souza PL; Stenzel MH, 2011, 'Polymeric micelles with pendant dicarboxylato chelating ligands prepared via a michael addition for cis -platinum drug delivery', Macromolecules, vol. 44, pp. 7888 - 7900, http://dx.doi.org/10.1021/ma2016503

Journal articles | 2011

Li S; de Souza P, 2011, 'Ras isoprenylation and pAkt inhibition by zoledronic acid and fluvastatin enhances paclitaxel activity in T24 bladder cancer cells', Cancers, vol. 3, pp. 662 - 674, http://dx.doi.org/10.3390/cancers3010662

Journal articles | 2011

Manners S; Galettis P; De Souza PL, 2011, 'Conditions causing gemcitabine crystallization', Journal of Oncology Pharmacy Practice, vol. 17, pp. 395 - 399, http://dx.doi.org/10.1177/1078155210385033

Journal articles | 2011

Xu C; Bing NX; Ball HA; Rajagopalan D; Sternberg CN; Hutson T; De Souza PL; Xue ZG; McCann L; King KS; Ragone LJ; Whittaker JC; Spraggs C; Cardon LR; Mooser VE; Pandite LN, 2011, 'Pazopanib efficacy in renal cell carcinoma: evidence for predictive genetic markers in angiogenesis-related and exposure-related genes', Journal of Clinical Oncology, vol. 29, pp. 2557 - 2564, http://dx.doi.org/10.1200/JCO.2010.32.9110

Journal articles | 2010

De Souza PL; Russell PJ; Kearsley J; Howes LG, 2010, 'Clinical pharmacology of isoflavones and its relevance for potential prevention of prostate cancer.', Nutrition Reviews, vol. 68, pp. 542 - 555, http://dx.doi.org/10.1111/j.1753-4887.2010.00314.x

Journal articles | 2010

Duong HTT; Huynh TV; De Souza PL; Stenzel M, 2010, 'Core-Crosslinked Micelles synthesized by Clicking Bifunctional Pt(IV) Anticancer Drugs to Isocyanates', Biomacromolecules, vol. 11, pp. 2290 - 2299, http://dx.doi.org/10.1021/bm100396s

Journal articles | 2010

Hutson TE; Davis ID; Machiels JPH; De Souza PL; Rottey S; Hong BF; Epstein RJ; Baker KL; McCann L; Crofts T; Pandite L; Figlin RA, 2010, 'Efficacy and safety of pazopanib in patients with metastatic renal cell carcinoma', Journal of Clinical Oncology, vol. 28, pp. 475 - 480, http://dx.doi.org/10.1200/JCO.2008.21.6994

Journal articles | 2010

Khasraw M; Pavlakis N; Mccowatt S; Underhill C; Begbie S; De Souza PL; Boyce A; Parnis F; Lim V; Harvie R; Marx G, 2010, 'Multicentre phase I/II study of PI-88, a heparanase inhibitor in combination with docetaxel in patients with metastatic castrate-resistant prostate cancer', Annals of Oncology, vol. 21, pp. 1302 - 1307, http://dx.doi.org/10.1093/annonc/mdp524

Journal articles | 2010

Scott KF; Sajinovic M; Hein J; Nixdorf S; Galettis P; Liauw WS; De Souza PL; Dong Q; Graham GG; Russell PJ, 2010, 'Emerging roles for phospholipase A2 enzymes in cancer', Biochimie, vol. 92, pp. 601 - 610, http://dx.doi.org/10.1016/j.biochi.2010.03.019

Journal articles | 2010

Yang S; De Souza PL; Alemao E; Purvis J, 2010, 'Quality of life in patients with advanced renal cell carcinoma treated with temsirolimus or interferon-alpha', British Journal of Cancer, vol. 102, pp. 1456 - 1460, http://dx.doi.org/10.1038/sj.bjc.6605647

Journal articles | 2009

Figlin R; De Souza PL; McDermott D; Dutcher J; Berkenblit A; Thiele A; Krygowski M; Strahs A; Feingold J; Boni J; Hudes G, 2009, 'Analysis of PTEN and HIF-1 alpha and Correlation With Efficacy in Patients With Advanced Renal Cell Carcinoma Treated With Temsirolimus Versus Interferon-alpha', Cancer, vol. 115, pp. 3651 - 3660, http://dx.doi.org/10.1002/cncr.24438

Journal articles | 2009

McPherson RAC; Galettis PT; De Souza PL, 2009, 'Enhancement of the activity of phenoxodiol by cisplatin in prostate cancer cells', British Journal of Cancer, vol. 100, pp. 649 - 655, http://dx.doi.org/10.1038/sj.bjc.6604920

Journal articles | 2009

Simonetti AC; Humberto de Lima Melo J; Eleutério de Souza PR; Bruneska D; Luiz de Lima Filho J, 2009, 'Immunological's host profile for HPV and Chlamydia trachomatis, a cervical cancer cofactor', Microbes and Infection, vol. 11, pp. 435 - 442, http://dx.doi.org/10.1016/j.micinf.2009.01.004

Journal articles | 2008

Amaral MB; Buchholz I; Freire-Maia B; Reher P; De Souza PEA; De Marigo HA; Martins CR; Horta MCR, 2008, 'Advanced osteosarcoma of the maxilla: A case report', Medicina Oral, Patologia Oral y Cirugia Bucal, vol. 13

Journal articles | 2006

De Souza PL; Liauw WS; Links MJ; Pirabhahar S; Kelly G; Lowes LG, 2006, 'Phase I and pharmacokinetic study of weekly NV06 (Phenoxodioltrade mark), a novel isoflav-3-ene, in patients with advanced cancer', Cancer Chemotherapy and Pharmacology, vol. 58, pp. 427 - 433, http://dx.doi.org/10.1007/s00280-006-0189-6

Journal articles | 2004

Rosen L; Gordon D; Tchekmedyian N; Yanagihara R; Hirsh V; Krzakowski M; Pawlicki M; De Souza PL; Zheng M; Urbanowitz G; Reitsma D; Seaman J, 2004, 'Long-term efficacy and safety of zoledronic acid in the treatment ofskeletal metastases in patients with nonsmall cell lung carcinoma andother solid tumors - A randomized, phase III, double-blind,placebo-controlled trial', Cancer, vol. 100, pp. 2613 - 2621, http://dx.doi.org/10.1002/cncr.20308

Journal articles | 2003

Rosen LS; Gordon D; Tchekmedyian S; Yanagihara R; Hirsh V; Krzakowski M; Pawlicki M; de Souza P; Zheng M; Urbanowitz G; Reitsma D; Seaman JJ, 2003, 'Zoledronic acid versus placebo in the treatment of skeletal metastases in patients with lung cancer and other solid tumors: A phase III, double-blind, randomized trial - The zoledronic acid lung cancer and other solid tumors study group', Journal of Clinical Oncology, vol. 21, pp. 3150 - 3157, http://dx.doi.org/10.1200/JCO.2003.04.105

Journal articles | 1997

De Souza PL; Castillo M; Myers CE, 1997, 'Enhancement of paclitaxel activity against hormone-refractory prostate cancer cells in vitro and in vivo by quinacrine', British Journal of Cancer, vol. 75, pp. 1593 - 1600, http://dx.doi.org/10.1038/bjc.1997.272

Journal articles | 1996

Stea S; Bachelor T; Cooper M; De Souza P; Koenig K; Bolton WK, 1996, 'Disposition and bioavailability of ceftazidime after intraperitoneal administration in patients receiving continuous ambulatory peritoneal dialysis', Journal of the American Society of Nephrology, vol. 7, pp. 2399 - 2402
Preprints | 2020

Wimmer M; Zauner R; Ablinger M; Piñón-Hofbauer J; Guttmann-Gruber C; Reisenberger M; Lettner T; Niklas N; Proell J; Sajinovic M; De Souza P; Hainzl S; Kocher T; Murauer EM; Bauer JW; Strunk D; Reichelt J; Mellick AS; Wally V, 2020, MiRNA-10b marks aggressive squamous cell carcinomas, and confers a cancer stem cell-like phenotype, http://dx.doi.org/10.1101/2020.02.05.934109

Conference Abstracts | 2019

Powderly JD; de Souza PL; Gutierrez R; Horvath L; Seitz L; Ashok D; Park A; Walters MJ; Karakunnel JJ; Berry W; Rieger A; Garofalo A; Lai DW; Chaudhry A, 2019, 'AB928, a novel dual adenosine receptor antagonist, combined with chemotherapy or AB122 (anti-PD-1) in patients (pts) with advanced tumors: Preliminary results from ongoing phase I studies.', in JOURNAL OF CLINICAL ONCOLOGY, AMER SOC CLINICAL ONCOLOGY, IL, Chicago, Vol. 37, presented at Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), IL, Chicago, 31 May 2019 - 04 June 2019, http://dx.doi.org/10.1200/JCO.2019.37.15_suppl.2604

Conference Abstracts | 2017

Carson E; Cooper A; De Souza P; Chua W, 2017, 'Retrospective Analysis of Clinical Characteristics and Outcomes for Patients Enrolled on Oncology Phase I Clinical Trials at Liverpool Hospital Cancer Therapy Centre', in ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, WILEY, Vol. 13, pp. 117 - 117, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000413954500150&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts | 2015

Basch EM; Sholz MC; De Bono JS; Vogelzang NJ; De Souza PL; Marx GM; Vaishampayan UN; George S; Schwarz JK; Antonarakis ES; O'Sullivan JM; Kelabasty AR; Chi KN; Dreicer R; Hutson TE; Mangeshkar M; Holland JS; Weitzman A; Scher HI, 2015, 'Final analysis COMET-2: Cabozantinib (Cabo) versus mitoxantrone/prednisone (MP) in metastatic castration-resistant prostate cancer (mCRPC) patients (pts) with moderate to severe pain who were previously treated with docetaxel(D) and abiraterone (A) and/or enzalutamide (E)', in JOURNAL OF CLINICAL ONCOLOGY, AMER SOC CLINICAL ONCOLOGY, FL, Orlando, Vol. 33, presented at Genitourinary Cancers Symposium, FL, Orlando, 26 February 2015 - 28 February 2015, http://dx.doi.org/10.1200/jco.2015.33.7_suppl.141

Conference Papers | 2014

Yu EY; Saad F; Londhe A; Shore ND; Van Poppel H; Rathkopf DE; Smith MR; Logothetis C; De Souza PL; Fizazi K; Mulders PFA; Mainwaring PN; Hainsworth JD; Beer TM; North SA; Small EJ; Scher HI; Griffin TW; Yu MK; Ryan CJ, 2014, 'Association of alkaline phosphatase (ALP) with clinical outcomes in chemotherapy-naive patients (pts) with metastatic castration-resistant prostate cancer (mCRPC): Results from COU-AA-302', in JOURNAL OF CLINICAL ONCOLOGY, AMER SOC CLINICAL ONCOLOGY, CA, San Francisco, presented at Genitourinary Cancers Symposium, CA, San Francisco, 30 January 2014 - 01 February 2014, http://dx.doi.org/10.1200/jco.2014.32.4_suppl.27

Conference Papers | 2012

Hovey EJ; De Souza P; Marx G; Parente P; Rapke T; et A, 2012, 'Phase III, randomised, double-blind, placebo-controlled study of Modafinil for fatigue in patients treated with Docetaxel-based chemotherapy', in Asia-Pacific Journal of Clinical Oncology, Blackwell Publishing Asia Pty Ltd, Australia, pp. 26 - 26, presented at ANZUP Annual Scientific Meeting, State of the art Multi-Disciplinary Care in Urological Cancers, Sydney Darling Harbour, 15 July 2012 - 17 July 2012, http://dx.doi.org/10.1111/j.1743-7563.2012.01574_3.x

Conference Papers | 2012

Lemech C; Fontela A; Arkenau H; Chin M; Li S; Liauw WS; Thomas D; De Souza P, 2012, 'Phase I study of everolimus in combination with fluvastatin and zoledronic acid in patients with solid tumours', in Journal of clinical oncology - official journal of the American Society of Clinical Oncology, American Society of Clinical Oncology, New York, pp. e13585 - e13585, presented at ASCO Annual Meeting, Chicago, USA, 01 June 2012 - 05 June 2012, http://meeting.ascopubs.org/gca?gca=ascomtg%3B30%2F15_suppl%2Fe13585&allch=&submit=Go#abstr-1

Conference Papers | 2012

Lim S; Descallar J; Sayaloune P; Papadatos G; De Souza P; Delaney GP, 2012, 'Outcomes of ethnic minority groups with node-positive, non-metastatic breast cancer in a tertiary referral centre in Sydney', in Annals of Oncology, Oxford Univ Press, Oxford, England, pp. 23 100-100; 9 SEP 2012, presented at ESMO Congress Vienna, http://dx.doi.org/10.1371/journal.pone.0095852

Conference Papers | 2012

Ryan CJ; Smith MR; De Bono JS; Molina A; Logothetis C; De Souza PL; Fizazi K; Mainwaring PN; Piulats Rodriguez JM; Ng S; Carles J; Mulders P; San Kheoh T; Griffin TW; Small EJ; Scher HI; Rathkopf DE, 2012, 'Interim analysis (IA) results of COU-AA-302, a randomized, phase III study of abiraterone acetate in chemotherapy-naive patients (pts) with metastatic castration-resistant prostate cancer (mCRPC).', in JOURNAL OF CLINICAL ONCOLOGY, AMER SOC CLINICAL ONCOLOGY, IL, Chicago, presented at 48th Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), IL, Chicago, 01 June 2012 - 06 June 2012, http://dx.doi.org/10.1200/jco.2012.30.18_suppl.lba4518

Conference Papers | 2009

Dutcher J; De Souza PL; McDermott D; Figlin R; Berkenblit A; Thiele A; Krygowski M; Strahs A; Feingold J; Hudes G, 2009, 'Effect of temsirolimus versus interferon-alpha on outcome of patients with advanced renal cell carcinoma of different tumor histologies', in Medical Oncology, Humana Press Inc, Totowa, NJ, USA, pp. 202 - 209, presented at Medical Oncology, http://dx.doi.org/10.1007/s12032-009-9177-0

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Professor Paul De Souza