Professor Peter Ian Croucher
Conjoint Professor

Professor Peter Ian Croucher

medicine-health
St Vincent's Clinical School

I am a bone biologist and cancer researcher, with a longstanding fascination for disorders of the skeleton, particularly osteoporosis and cancer-associated bone disease. I have a particular interest in the molecular mechanisms of bone disease, in how cancers spread to bone, and what controls dormancy (sleeping) and reactivation of cancer cells within bone. I am motivated by the clinical impacts that my research has already had, and by the potential for widespread future impacts on bone disease, cancer relapse and metastasis.

I head Garvan’s Bone Biology research lab. I also lead and co-lead a number of international research consortia, including ProMis (PROstate Cancer MetastasIS; co-funded by Movember and the Prostate Cancer Foundation) and the Wellcome Trust-funded Origins of Bone & Cartilage Disease program.

My postdoctoral training was at the University of Cambridge and the University of Sheffield. I relocated to the University of Oxford’s Institute of Musculoskeletal Sciences as a Senior Research Fellow in 2001, returning to the School of Medicine and Biomedical Sciences at the University of Sheffield in 2003 as Professor of Bone Biology. In 2009 I formed and led the new Department of Human Metabolism, and became the inaugural co-Director of the Mellanby Centre for Bone Research.

In 2011, I moved to Garvan, in Sydney, to lead its Division of Bone Biology and to take up the inaugural Mrs Janice Gibson & the Ernest Heine Family Foundation Chair in Osteoporosis. As of 2018, I lead Garvan’s Healthy Ageing research theme, which brings together a multidisciplinary group of over 150 researchers and clinician-scientists who study osteoporosis, cancer in bone, type 2 diabetes and disorders of metabolism, neurodegenerative diseases, other neurological conditions and hearing. I am also Deputy Director of Garvan, with responsibilities for whole-of-institute scientific affairs.

Phone
9295 8100
Location
Garvan Institute of Medical Research, Victoria Street Darlinghurst NSW 2010

Publications

  • Book Chapters | 2010
    Professor Peter Ian Croucher
    Croucher PI; Vanderkerken K; Epstein J; Oyajobi B, 2010, 'Murine Models of Myeloma Bone Disease: The Importance of Choice', in Myeloma Bone Disease, Humana Press, pp. 151 - 168, http://dx.doi.org/10.1007/978-1-60761-554-5_8
    Book Chapters | 2006
    Professor Peter Ian Croucher
    Coleman RE; Croucher PI, 2006, 'Osteoblastic Metastases', in Textbook of Bone Metastases, pp. 41 - 50, http://dx.doi.org/10.1002/0470011610.ch3
    Book Chapters | 2006
    Professor Peter Ian Croucher
    Hulley P; Russell G; Croucher P, 2006, 'Chapter 6 Growth Factors', in Dynamics of Bone and Cartilage Metabolism, pp. 99 - 113, http://dx.doi.org/10.1016/b978-012088562-6/50007-8
    Book Chapters | 2006
    Professor Peter Ian Croucher
    Hulley P; Russell G; Croucher P, 2006, 'Growth Factors', in Dynamics of Bone and Cartilage Metabolism, pp. 99 - 113, http://dx.doi.org/10.1016/B978-012088562-6/50007-8
    Book Chapters | 2000
    Professor Peter Ian Croucher
    Croucher PI; Holen I; Hargreaves PG, 2000, 'Inhibiting cytokine-processing enzymes', in Novel Cytokine Inhibitors, Birkhäuser Basel, pp. 103 - 122, http://dx.doi.org/10.1007/978-3-0348-8450-1_5
    Book Chapters | 1990
    Professor Peter Ian Croucher
    Wright CDP; Crawley EO; Evans WD; Garrahan NJ; Mellish RWE; Croucher PI; Compston JE, 1990, 'The Relationship Between Spinal Trabecular Bone Mineral Content and Iliac Crest Trabecular Bone Volume', in In Vivo Body Composition Studies, pp. 79 - 82, http://dx.doi.org/10.1007/978-1-4613-1473-8_11
  • Journal articles | 2021
    Professor Peter Ian Croucher
    McDonald MM; Khoo WH; Ng PY; Xiao Y; Zamerli J; Thatcher P; Kyaw W; Pathmanandavel K; Grootveld AK; Moran I; Butt D; Nguyen A; Warren S; Biro M; Butterfield NC; Guilfoyle SE; Komla-Ebri D; Dack MRG; Dewhurst HF; Logan JG; Li Y; Mohanty ST; Byrne N; Terry RL; Simic MK; Chai R; Quinn JMW; Youlten SE; Pettitt JA; Abi-Hanna D; Jain R; Weninger W; Lundberg M; Sun S; Ebetino FH; Timpson P; Lee WM; Baldock PA; Rogers MJ; Brink R; Williams GR; Bassett JHD; Kemp JP; Pavlos NJ; Croucher PI; Phan TG, 2021, 'Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption', Cell, vol. 184, pp. 1330 - 1347.e13, http://dx.doi.org/10.1016/j.cell.2021.02.002
    Journal articles | 2021
    Professor Peter Ian Croucher
    Youlten SE; Kemp JP; Logan JG; Ghirardello EJ; Sergio CM; Dack MRG; Guilfoyle SE; Leitch VD; Butterfield NC; Komla-Ebri D; Chai RC; Corr AP; Smith JT; Mohanty ST; Morris JA; McDonald MM; Quinn JMW; McGlade AR; Bartonicek N; Jansson M; Hatzikotoulas K; Irving MD; Beleza-Meireles A; Rivadeneira F; Duncan E; Richards JB; Adams DJ; Lelliott CJ; Brink R; Phan TG; Eisman JA; Evans DM; Zeggini E; Baldock PA; Bassett JHD; Williams GR; Croucher PI, 2021, 'Osteocyte transcriptome mapping identifies a molecular landscape controlling skeletal homeostasis and susceptibility to skeletal disease', Nature Communications, vol. 12, pp. 2444, http://dx.doi.org/10.1038/s41467-021-22517-1
    Journal articles | 2021
    Professor Peter Ian Croucher
    Butterfield NC; Curry KF; Steinberg J; Dewhurst H; Komla-Ebri D; Mannan NS; Adoum AT; Leitch VD; Logan JG; Waung JA; Ghirardello E; Southam L; Youlten SE; Wilkinson JM; McAninch EA; Vancollie VE; Kussy F; White JK; Lelliott CJ; Adams DJ; Jacques R; Bianco AC; Boyde A; Zeggini E; Croucher PI; Williams GR; Bassett JHD, 2021, 'Accelerating functional gene discovery in osteoarthritis', Nature Communications, vol. 12, http://dx.doi.org/10.1038/s41467-020-20761-5
    Journal articles | 2021
    Professor Peter Ian Croucher
    Brown JE; Wood SL; Confavreux C; Abe M; Weilbaecher K; Hadji P; Johnson RW; Rhoades JA; Edwards CM; Croucher PI; Juarez P; El Badri S; Ariaspinilla G; D'Oronzo S; Guise TA; Van Poznak C, 2021, 'Management of bone metastasis and cancer treatment-induced bone loss during the COVID-19 pandemic: An international perspective and recommendations', Journal of Bone Oncology, vol. 29, pp. 100375, http://dx.doi.org/10.1016/j.jbo.2021.100375
    Journal articles | 2021
    Professor Peter Ian Croucher
    McDonald MM; Khoo WH; Ng PY; Xiao Y; Zamerli J; Thatcher P; Kyaw W; Pathmanandavel K; Grootveld AK; Moran I; Butt D; Nguyen A; Corr A; Warren S; Biro M; Butterfield NC; Guilfoyle SE; Komla-Ebri D; Dack MRG; Dewhurst HF; Logan JG; Li Y; Mohanty ST; Byrne N; Terry RL; Simic MK; Chai R; Quinn JMW; Youlten SE; Pettitt JA; Abi-Hanna D; Jain R; Weninger W; Lundberg M; Sun S; Ebetino FH; Timpson P; Lee WM; Baldock PA; Rogers MJ; Brink R; Williams GR; Bassett JHD; Kemp JP; Pavlos NJ; Croucher PI; Phan TG, 2021, 'Erratum: Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption (Cell (2021) 184(5) (1330–1347.e13), (S0092867421001525), (10.1016/j.cell.2021.02.002))', Cell, vol. 184, pp. 1940, http://dx.doi.org/10.1016/j.cell.2021.03.010
    Journal articles | 2021
    Professor Peter Ian Croucher
    Butterfield NC; Curry KF; Steinberg J; Dewhurst H; Komla-Ebri D; Mannan NS; Adoum AT; Leitch VD; Logan JG; Waung JA; Ghirardello E; Southam L; Youlten SE; Wilkinson JM; McAninch EA; Vancollie VE; Kussy F; White JK; Lelliott CJ; Adams DJ; Jacques R; Bianco AC; Boyde A; Zeggini E; Croucher PI; Williams GR; Bassett JHD, 2021, 'Publisher Correction: Accelerating functional gene discovery in osteoarthritis (Nature Communications, (2021), 12, 1, (467), 10.1038/s41467-020-20761-5)', Nature Communications, vol. 12, http://dx.doi.org/10.1038/s41467-021-23768-8
    Journal articles | 2021
    Professor Peter Ian Croucher
    Terpos E; Raje N; Croucher P; Garcia-Sanz R; Leleu X; Pasteiner W; Wang Y; Glennane A; Canon J; Pawlyn C, 2021, 'Denosumab compared with zoledronic acid on PFS in multiple myeloma: Exploratory results of an international phase 3 study', Blood Advances, vol. 5, pp. 725 - 736, http://dx.doi.org/10.1182/bloodadvances.2020002378
    Journal articles | 2020
    Professor Peter Ian Croucher
    Phan TG; Croucher PI, 2020, 'The dormant cancer cell life cycle', Nature Reviews Cancer, vol. 20, pp. 398 - 411, http://dx.doi.org/10.1038/s41568-020-0263-0
    Journal articles | 2020
    Professor Peter Ian Croucher
    Gregson CL; Bergen DJM; Leo P; Sessions RB; Wheeler L; Hartley A; Youlten S; Croucher PI; McInerney-Leo AM; Fraser W; Tang JCY; Anderson L; Marshall M; Sergot L; Paternoster L; Davey Smith G; Brown MA; Hammond C; Kemp JP; Tobias JH; Duncan EL, 2020, 'A Rare Mutation in SMAD9 Associated With High Bone Mass Identifies the SMAD-Dependent BMP Signaling Pathway as a Potential Anabolic Target for Osteoporosis', Journal of Bone and Mineral Research, vol. 35, pp. 92 - 105, http://dx.doi.org/10.1002/jbmr.3875
    Journal articles | 2020
    Professor Peter Ian Croucher
    Coleman RE; Croucher PI; Padhani AR; Clézardin P; Chow E; Fallon M; Guise T; Colangeli S; Capanna R; Costa L, 2020, 'Bone metastases', Nature Reviews Disease Primers, vol. 6, http://dx.doi.org/10.1038/s41572-020-00216-3
    Journal articles | 2020
    Professor Peter Ian Croucher
    Zeissig MN; Hewett DR; Panagopoulos V; Mrozik KM; To LB; Croucher PI; Zannettino ACW; Vandyke K, 2020, 'Expression of the chemokine receptor CCR1 promotes the dissemination of multiple myeloma plasma cells <em>in vivo</em>', Haematologica, vol. Online ahead of print, http://dx.doi.org/10.3324/haematol.2020.253526
    Journal articles | 2020
    Professor Peter Ian Croucher
    Owen KL; Gearing LJ; Zanker DJ; Brockwell NK; Khoo WH; Roden DL; Cmero M; Mangiola S; Hong MK; Spurling AJ; McDonald M; Chan CL; Pasam A; Lyons RJ; Duivenvoorden HM; Ryan A; Butler LM; Mariadason JM; Giang Phan T; Hayes VM; Sandhu S; Swarbrick A; Corcoran NM; Hertzog PJ; Croucher PI; Hovens C; Parker BS, 2020, 'Prostate cancer cell-intrinsic interferon signaling regulates dormancy and metastatic outgrowth in bone', EMBO Reports, vol. 21, http://dx.doi.org/10.15252/embr.202050162
    Journal articles | 2020
    Professor Peter Ian Croucher
    Summers MA; McDonald MM; Croucher PI, 2020, 'Cancer cell dormancy in metastasis', Cold Spring Harbor Perspectives in Medicine, vol. 10, pp. 1 - 9, http://dx.doi.org/10.1101/cshperspect.a037556
    Journal articles | 2020
    Professor Peter Ian Croucher
    Swan AL; Schütt C; Rozman J; del Mar Muñiz Moreno M; Brandmaier S; Simon M; Leuchtenberger S; Griffiths M; Brommage R; Keskivali-Bond P; Grallert H; Werner T; Teperino R; Becker L; Miller G; Moshiri A; Seavitt JR; Cissell DD; Meehan TF; Acar EF; Lelliott CJ; Flenniken AM; Champy MF; Sorg T; Ayadi A; Braun RE; Cater H; Dickinson ME; Flicek P; Gallegos J; Ghirardello EJ; Heaney JD; Jacquot S; Lally C; Logan JG; Teboul L; Mason J; Spielmann N; McKerlie C; Murray SA; Nutter LMJ; Odfalk KF; Parkinson H; Prochazka J; Reynolds CL; Selloum M; Spoutil F; Svenson KL; Vales TS; Wells SE; White JK; Sedlacek R; Wurst W; Lloyd KKC; Croucher PI; Fuchs H; Williams GR; Bassett D; Gailus-Durner V; Herault Y; Mallon AM; Brown SDM; Mayer-Kuckuk P; de Angelis MH; Ackert-Bicknell C; Adams DJ; Adams D; Adoum AT; Aguilar-Pimentel JA; Ali-Hadji D; Amarie OV; André P; Aurelie ; Auburtin ; Bam’Hamed C; Beckers J; Beig J; Berberovic Z; Bezginov A; Birling MC; Boroviak K; Bottomley J; Bower L; Bubshait M; Bürger A; Busch DH; Butterfield NC; Cabezas J; Cacheiro P; Calzada-Wack J; Cambridge EL; Camilleri S; Carroll T; Charles P; Chesler EJ; Cho YL; Cipriani V; Clark G; Clarke S; Clary D, 2020, 'Mouse mutant phenotyping at scale reveals novel genes controlling bone mineral density', PLoS Genetics, vol. 16, http://dx.doi.org/10.1371/journal.pgen.1009190
    Journal articles | 2020
    Professor Peter Ian Croucher
    Pereira M; Ko JH; Logan J; Protheroe H; Kim KB; Tan ALM; Croucher PI; Park KS; Rotival M; Petretto E; Bassett JD; Williams GR; Behmoaras J, 2020, 'A trans-eqtl network regulates osteoclast multinucleation and bone mass', eLife, vol. 9, pp. 1 - 21, http://dx.doi.org/10.7554/eLife.55549
    Journal articles | 2020
    Professor Peter Ian Croucher
    Crumbaker M; Chan EKF; Gong T; Corcoran N; Jaratlerdsiri W; Lyons RJ; Haynes AM; Kulidjian AA; Kalsbeek AMF; Petersen DC; Stricker PD; Jamieson CAM; Croucher PI; Hovens CM; Joshua AM; Hayes VM, 2020, 'The impact of whole genome data on therapeutic decision‐making in metastatic prostate cancer: A retrospective analysis', Cancers, vol. 12, http://dx.doi.org/10.3390/cancers12051178
    Journal articles | 2019
    Professor Peter Ian Croucher
    Khoo WH; Ledergor G; Weiner A; Roden DL; Terry RL; McDonald MM; Chai RC; De Veirman K; Owen KL; Opperman KS; Vandyke K; Clark JR; Seckinger A; Kovacic N; Nguyen A; Mohanty ST; Pettitt JA; Xiao Y; Corr AP; Seeliger C; Novotny M; Lasken RS; Nguyen TV; Oyajobi BO; Aftab D; Swarbrick A; Parker B; Hewett DR; Hose D; Vanderkerken K; Zannettino ACW; Amit I; Phan TG; Croucher PI, 2019, 'A niche-dependent myeloid transcriptome signature defines dormant myeloma cells', Blood, vol. 134, pp. 30 - 43, http://dx.doi.org/10.1182/blood.2018880930
    Journal articles | 2019
    Professor Peter Ian Croucher
    Leitch VD; Brassill MJ; Rahman S; Butterfield NC; Ma P; Logan JG; Boyde A; Evans H; Croucher PI; Batterham RL; Williams GR; Bassett JHD, 2019, 'PYY is a negative regulator of bone mass and strength', Bone, vol. 127, pp. 427 - 435, http://dx.doi.org/10.1016/j.bone.2019.07.011
    Journal articles | 2019
    Professor Peter Ian Croucher
    Horas K; Zheng Y; Fong-Yee C; Macfarlane E; Manibo J; Chen Y; Qiao J; Gao M; Haydar N; McDonald MM; Croucher PI; Zhou H; Seibel MJ, 2019, 'Loss of the Vitamin D Receptor in Human Breast Cancer Cells Promotes Epithelial to Mesenchymal Cell Transition and Skeletal Colonization', Journal of Bone and Mineral Research, vol. 34, pp. 1721 - 1732, http://dx.doi.org/10.1002/jbmr.3744
    Journal articles | 2019
    Professor Peter Ian Croucher
    Opperman KS; Vandyke K; Clark KC; Coulter EA; Hewett DR; Mrozik KM; Schwarz N; Evdokiou A; Croucher PI; Psaltis PJ; Noll JE; Zannettino AC, 2019, 'Clodronate-Liposome Mediated Macrophage Depletion Abrogates Multiple Myeloma Tumor Establishment In Vivo', Neoplasia (United States), vol. 21, pp. 777 - 787, http://dx.doi.org/10.1016/j.neo.2019.05.006
    Journal articles | 2019
    Professor Peter Ian Croucher
    Faraahi Z; Baud'huin M; Croucher PI; Eaton C; Lawson MA, 2019, 'Sostdc1: A soluble BMP and Wnt antagonist that is induced by the interaction between myeloma cells and osteoblast lineage cells', Bone, vol. 122, pp. 82 - 92, http://dx.doi.org/10.1016/j.bone.2019.02.012
    Journal articles | 2019
    Professor Peter Ian Croucher
    Morris JA; Kemp JP; Youlten SE; Laurent L; Logan JG; Chai RC; Vulpescu NA; Forgetta V; Kleinman A; Mohanty ST; Sergio CM; Quinn J; Nguyen-Yamamoto L; Luco AL; Vijay J; Simon MM; Pramatarova A; Medina-Gomez C; Trajanoska K; Ghirardello EJ; Butterfield NC; Curry KF; Leitch VD; Sparkes PC; Adoum AT; Mannan NS; Komla-Ebri DSK; Pollard AS; Dewhurst HF; Hassall TAD; Beltejar MJG; Agee M; Alipanahi B; Auton A; Bell RK; Bryc K; Elson SL; Fontanillas P; Furlotte NA; McCreight JC; Huber KE; Litterman NK; McIntyre MH; Mountain JL; Noblin ES; Northover CAM; Pitts SJ; Sathirapongsasuti JF; Sazonova OV; Shelton JF; Shringarpure S; Tian C; Tung JY; Vacic V; Wilson CH; Adams DJ; Vaillancourt SM; Kaptoge S; Baldock P; Cooper C; Reeve J; Ntzani EE; Evangelou E; Ohlsson C; Karasik D; Rivadeneira F; Kiel DP; Tobias JH; Gregson CL; Harvey NC; Grundberg E; Goltzman D; Adams DJ; Lelliott CJ; Hinds DA; Ackert-Bicknell CL; Hsu YH; Maurano MT; Croucher PI; Williams GR; Bassett JHD; Evans DM; Richards JB, 2019, 'An atlas of genetic influences on osteoporosis in humans and mice', Nature Genetics, vol. 51, pp. 258 - 266, http://dx.doi.org/10.1038/s41588-018-0302-x
    Journal articles | 2019
    Professor Peter Ian Croucher
    Morris JA; Kemp JP; Youlten SE; Laurent L; Logan JG; Chai RC; Vulpescu NA; Forgetta V; Kleinman A; Mohanty ST; Sergio CM; Quinn J; Nguyen-Yamamoto L; Luco AL; Vijay J; Simon MM; Pramatarova A; Medina-Gomez C; Trajanoska K; Ghirardello EJ; Butterfield NC; Curry KF; Leitch VD; Sparkes PC; Adoum AT; Mannan NS; Komla-Ebri DSK; Pollard AS; Dewhurst HF; Hassall TAD; Beltejar MJG; Agee M; Alipanahi B; Auton A; Bell RK; Bryc K; Elson SL; Fontanillas P; Furlotte NA; McCreight JC; Huber KE; Litterman NK; McIntyre MH; Mountain JL; Noblin ES; Northover CAM; Pitts SJ; Sathirapongsasuti JF; Sazonova OV; Shelton JF; Shringarpure S; Tian C; Tung JY; Vacic V; Wilson CH; Adams DJ; Vaillancourt SM; Kaptoge S; Baldock P; Cooper C; Reeve J; Ntzani EE; Evangelou E; Ohlsson C; Karasik D; Rivadeneira F; Kiel DP; Tobias JH; Gregson CL; Harvey NC; Grundberg E; Goltzman D; Adams DJ; Lelliott CJ; Hinds DA; Ackert-Bicknell CL; Hsu YH; Maurano MT; Croucher PI; Williams GR; Bassett JHD; Evans DM; Richards JB, 2019, 'Author Correction: An atlas of genetic influences on osteoporosis in humans and mice (Nature Genetics, (2019), 51, 2, (258-266), 10.1038/s41588-018-0302-x)', Nature Genetics, vol. 51, pp. 920, http://dx.doi.org/10.1038/s41588-019-0415-x
    Journal articles | 2019
    Professor Peter Ian Croucher
    Faraahi Z; Baud'huin M; Croucher PI; Eaton C; Lawson MA, 2019, 'Corrigendum to “Sostdc1: A soluble BMP and Wnt antagonist that is induced by the interaction between myeloma cells and osteoblast lineage cells” (Bone (2019) 122 (82–92), (S8756328219300523), (10.1016/j.bone.2019.02.012))', Bone, vol. 124, pp. 166, http://dx.doi.org/10.1016/j.bone.2019.04.020
    Journal articles | 2018
    Professor Peter Ian Croucher
    Fairfield H; Falank C; Harris E; Demambro V; McDonald M; Pettitt JA; Mohanty ST; Croucher P; Kramer I; Kneissel M; Rosen CJ; Reagan MR, 2018, 'The skeletal cell-derived molecule sclerostin drives bone marrow adipogenesis', Journal of Cellular Physiology, vol. 233, pp. 1156 - 1167, http://dx.doi.org/10.1002/jcp.25976
    Journal articles | 2018
    Professor Peter Ian Croucher
    Gregson CL; Newell F; Leo PJ; Clark GR; Paternoster L; Marshall M; Forgetta V; Morris JA; Ge B; Bao X; Duncan Bassett JH; Williams GR; Youlten SE; Croucher PI; Davey Smith G; Evans DM; Kemp JP; Brown MA; Tobias JH; Duncan EL, 2018, 'Genome-wide association study of extreme high bone mass: Contribution of common genetic variation to extreme BMD phenotypes and potential novel BMD-associated genes', Bone, vol. 114, pp. 62 - 71, http://dx.doi.org/10.1016/j.bone.2018.06.001
    Journal articles | 2018
    Professor Peter Ian Croucher
    Esapa CT; Piret SE; Nesbit MA; Thomas GP; Coulton LA; Gallagher OM; Simon MM; Kumar S; Mallon AM; Bellantuono I; Brown MA; Croucher PI; Potter PK; Brown SDM; Cox RD; Thakker RV, 2018, 'An N-Ethyl-N-Nitrosourea (ENU) Mutagenized Mouse Model for Autosomal Dominant Nonsyndromic Kyphoscoliosis Due to Vertebral Fusion', JBMR Plus, vol. 2, pp. 154 - 163, http://dx.doi.org/10.1002/jbm4.10033
    Journal articles | 2018
    Professor Peter Ian Croucher
    Medina-Gomez C; Kemp JP; Trajanoska K; Luan J; Chesi A; Ahluwalia TS; Mook-Kanamori DO; Ham A; Hartwig FP; Evans DS; Joro R; Nedeljkovic I; Zheng HF; Zhu K; Atalay M; Liu CT; Nethander M; Broer L; Porleifsson G; Mullin BH; Handelman SK; Nalls MA; Jessen LE; Heppe DHM; Richards JB; Wang C; Chawes B; Schraut KE; Amin N; Wareham N; Karasik D; Van der Velde N; Ikram MA; Zemel BS; Zhou Y; Carlsson CJ; Liu Y; McGuigan FE; Boer CG; Bønnelykke K; Ralston SH; Robbins JA; Walsh JP; Zillikens MC; Langenberg C; Li-Gao R; Williams FMK; Harris TB; Akesson K; Jackson RD; Sigurdsson G; den Heijer M; van der Eerden BCJ; van de Peppel J; Spector TD; Pennell C; Horta BL; Felix JF; Zhao JH; Wilson SG; de Mutsert R; Bisgaard H; Styrkársdóttir U; Jaddoe VW; Orwoll E; Lakka TA; Scott R; Grant SFA; Lorentzon M; van Duijn CM; Wilson JF; Stefansson K; Psaty BM; Kiel DP; Ohlsson C; Ntzani E; van Wijnen AJ; Forgetta V; Ghanbari M; Logan JG; Williams GR; Bassett JHD; Croucher PI; Evangelou E; Uitterlinden AG; Ackert-Bicknell CL; Tobias JH; Evans DM; Rivadeneira F, 2018, 'Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects', American Journal of Human Genetics, vol. 102, pp. 88 - 102, http://dx.doi.org/10.1016/j.ajhg.2017.12.005
    Journal articles | 2018
    Professor Peter Ian Croucher
    Brown HK; Allocca G; Ottewell PD; Wang N; Brown NJ; Croucher PI; Eaton CL; Holen I, 2018, 'Parathyroid hormone (PTH) increases skeletal tumour growth and alters tumour distribution in an in vivo model of breast cancer', International Journal of Molecular Sciences, vol. 19, http://dx.doi.org/10.3390/ijms19102920
    Journal articles | 2018
    Professor Peter Ian Croucher
    Nguyen A; Khoo WH; Moran I; Croucher PI; Phan TG, 2018, 'Single cell RNA sequencing of rare immune cell populations', Frontiers in Immunology, vol. 9, http://dx.doi.org/10.3389/fimmu.2018.01553
    Journal articles | 2018
    Professor Peter Ian Croucher
    2018, 'Bone Research Society Abstracts', JBMR Plus, vol. 2, pp. S1 - S50, http://dx.doi.org/10.1002/jbm4.10073
    Journal articles | 2018
    Professor Peter Ian Croucher
    McDonald MM; Morse A; Schindeler A; Mikulec K; Peacock L; Cheng T; Bobyn J; Lee L; Baldock PA; Croucher PI; Tam PPL; Little DG, 2018, 'Homozygous Dkk1 Knockout Mice Exhibit High Bone Mass Phenotype Due to Increased Bone Formation', Calcified Tissue International, vol. 102, pp. 105 - 116, http://dx.doi.org/10.1007/s00223-017-0338-4
    Journal articles | 2018
    Professor Peter Ian Croucher
    Moran I; Nguyen A; Khoo WH; Butt D; Bourne K; Young C; Hermes JR; Biro M; Gracie G; Ma CS; Munier CML; Luciani F; Zaunders J; Parker A; Kelleher AD; Tangye SG; Croucher PI; Brink R; Read MN; Phan TG, 2018, 'Memory B cells are reactivated in subcapsular proliferative foci of lymph nodes', Nature Communications, vol. 9, http://dx.doi.org/10.1038/s41467-018-05772-7
    Journal articles | 2017
    Professor Peter Ian Croucher
    McDonald MM; Reagan MR; Youlten SE; Mohanty ST; Seckinger A; Terry RL; Pettitt JA; Simic MK; Cheng TL; Morse A; Le LMT; Abi-Hanna D; Kramer I; Falank C; Fairfield H; Ghobrial IM; Baldock PA; Little DG; Kneissel M; Vanderkerken K; Bassett JHD; Williams GR; Oyajobi BO; Hose D; Phan TG; Croucher PI, 2017, 'Inhibiting the osteocyte-specific protein sclerostin increases bone mass and fracture resistance in multiple myeloma', Blood, vol. 129, pp. 3452 - 3464, http://dx.doi.org/10.1182/blood-2017-03-773341
    Journal articles | 2017
    Professor Peter Ian Croucher
    Jaratlerdsiri W; Chan EKF; Petersen DC; Yang C; Croucher PI; Bornman MSR; Sheth P; Hayes VM, 2017, 'Next generation mapping reveals novel large genomic rearrangements in prostate cancer', Oncotarget, vol. 8, pp. 23588 - 23602, http://dx.doi.org/10.18632/oncotarget.15802
    Journal articles | 2017
    Professor Peter Ian Croucher
    Vandyke K; Zeissig MN; Hewett DR; Martin SK; Mrozik KM; Cheong CM; Diamond P; To LB; Gronthos S; Peet DJ; Croucher PI; Zannettino ACW, 2017, 'HIF-2α promotes dissemination of plasma cells in multiple myeloma by regulating CXCL12/CXCR4 and CCR1', Cancer Research, vol. 77, pp. 5452 - 5463, http://dx.doi.org/10.1158/0008-5472.CAN-17-0115
    Journal articles | 2017
    Professor Peter Ian Croucher
    Kemp JP; Morris JA; Medina-Gomez C; Forgetta V; Warrington NM; Youlten SE; Zheng J; Gregson CL; Grundberg E; Trajanoska K; Logan JG; Pollard AS; Sparkes PC; Ghirardello EJ; Allen R; Leitch VD; Butterfield NC; Komla-Ebri D; Adoum AT; Curry KF; White JK; Kussy F; Greenlaw KM; Xu C; Harvey NC; Cooper C; Adams DJ; Greenwood CMT; Maurano MT; Kaptoge S; Rivadeneira F; Tobias JH; Croucher PI; Ackert-Bicknell CL; Bassett JHD; Williams GR; Richards JB; Evans DM, 2017, 'Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis', Nature Genetics, vol. 49, pp. 1468 - 1475, http://dx.doi.org/10.1038/ng.3949
    Journal articles | 2017
    Professor Peter Ian Croucher
    Chai RC; McDonald MM; Terry RL; Kovacic N; Down JM; Pettitt JA; Mohanty ST; Shah S; Haffari G; Xu J; Gillespie MT; Rogers MJ; Price JT; Croucher PI; Quinn JMW, 2017, 'Melphalan modifies the bone microenvironment by enhancing osteoclast formation', ONCOTARGET, vol. 8, pp. 68047 - 68058, http://dx.doi.org/10.18632/oncotarget.19152
    Journal articles | 2017
    Professor Peter Ian Croucher
    Leitch VD; Di Cosmo C; Liao XH; O'Boy S; Galliford TM; Evans H; Croucher PI; Boyde A; Dumitrescu A; Weiss RE; Refetoff S; Williams GR; Bassett JHD, 2017, 'An essential physiological role for MCT8 in bone in male mice', Endocrinology, vol. 158, pp. 3055 - 3066, http://dx.doi.org/10.1210/en.2017-00399
    Journal articles | 2017
    Professor Peter Ian Croucher
    Hewett DR; Vandyke K; Lawrence DM; Friend N; Noll JE; Geoghegan JM; Croucher PI; Zannettino ACW, 2017, 'DNA Barcoding Reveals Habitual Clonal Dominance of Myeloma Plasma Cells in the Bone Marrow Microenvironment', Neoplasia (United States), vol. 19, pp. 972 - 981, http://dx.doi.org/10.1016/j.neo.2017.09.004
    Journal articles | 2017
    Professor Peter Ian Croucher
    Nobis M; Herrmann D; Warren SC; Kadir S; Leung W; Killen M; Magenau A; Stevenson D; Lucas MC; Reischmann N; Vennin C; Conway JRW; Boulghourjian A; Zaratzian A; Law AM; Gallego-Ortega D; Ormandy CJ; Walters SN; Grey ST; Bailey J; Chtanova T; Quinn JMW; Baldock PA; Croucher PI; Schwarz JP; Mrowinska A; Zhang L; Herzog H; Masedunskas A; Hardeman EC; Gunning PW; del Monte-Nieto G; Harvey RP; Samuel MS; Pajic M; McGhee EJ; Johnsson AKE; Sansom OJ; Welch HCE; Morton JP; Strathdee D; Anderson KI; Timpson P, 2017, 'A RhoA-FRET Biosensor Mouse for Intravital Imaging in Normal Tissue Homeostasis and Disease Contexts', Cell Reports, vol. 21, pp. 274 - 288, http://dx.doi.org/10.1016/j.celrep.2017.09.022
    Journal articles | 2017
    Professor Peter Ian Croucher
    Leitch VD; Di CC; Liao X-H; O'Boy S; Galliford TM; Evans H; Croucher PI; Boyde A; Dumitrescu A; Weiss RE; Refetoff S; Williams GR; Duncan BJH, 2017, 'An essential physiological role for MCT8 in bone', Endocrine Abstracts, http://dx.doi.org/10.1530/endoabs.50.oc1.5
    Journal articles | 2016
    Professor Peter Ian Croucher
    Kassen D; Lath D; Lach A; Evans H; Chantry A; Rabin N; Croucher P; Yong KL, 2016, 'Myeloma impairs mature osteoblast function but causes early expansion of osteo-progenitors: Temporal changes in bone physiology and gene expression in the KMS12BM model', British Journal of Haematology, vol. 172, pp. 64 - 79, http://dx.doi.org/10.1111/bjh.13790
    Journal articles | 2016
    Professor Peter Ian Croucher
    Freudenthal B; Logan J; Sanger Institute Mouse Pipelines ; Croucher PI; Williams GR; Duncan Bassett JH, 2016, 'Rapid phenotyping of knockout mice to identify genetic determinants of bone strength', Journal of Endocrinology, vol. 231, pp. 1 - 16, http://dx.doi.org/10.1530/JOE-16-0258
    Journal articles | 2016
    Professor Peter Ian Croucher
    Khor EC; Fanshawe B; Qi Y; Zolotukhin S; Kulkarni RN; Enriquez RF; Purtell L; Lee NJ; Wee NK; Croucher PI; Campbell L; Herzog H; Baldock PA, 2016, 'Prader-willi critical region, a non-translated, imprinted central regulator of bone mass: Possible role in skeletal abnormalities in Prader-Willi Syndrome', PLoS ONE, vol. 11, http://dx.doi.org/10.1371/journal.pone.0148155
    Journal articles | 2016
    Professor Peter Ian Croucher
    Croucher PI; McDonald MM; Martin TJ, 2016, 'Bone metastasis: The importance of the neighbourhood', Nature Reviews Cancer, vol. 16, pp. 373 - 386, http://dx.doi.org/10.1038/nrc.2016.44
    Journal articles | 2016
    Professor Peter Ian Croucher
    Esapa CT; Piret SE; Nesbit MA; Loh NY; Thomas G; Croucher PI; Brown MA; Brown SDM; Cox RD; Thakker RV, 2016, 'Mice with an N-Ethyl-N-Nitrosourea (ENU) induced Tyr209Asn mutation in natriuretic peptide receptor 3 (NPR3) provide a model for kyphosis associated with activation of the MAPK signaling pathway', PLoS ONE, vol. 11, http://dx.doi.org/10.1371/journal.pone.0167916
    Journal articles | 2016
    Professor Peter Ian Croucher
    McDonald M; Reagan M; Terry R; Pettitt J; Le L; Mohanty S; Kramer I; Kneissel M; Brooks D; Cheng T; Little D; Bouxsein M; Rosen C; Ghobrial I; Croucher P, 2016, 'Anti-sclerostin treatment prevents multiple myeloma bone disease and reduces tumour burden', Bone Abstracts, http://dx.doi.org/10.1530/boneabs.5.cabs.oc3.4
    Journal articles | 2016
    Professor Peter Ian Croucher
    Kulkarni R; Schindeler A; Croucher P; Little D; Baldock P, 2016, 'Is circulating sclerostin an endocrine modulator of bone mass?', Bone Abstracts, http://dx.doi.org/10.1530/boneabs.5.oc2.5
    Journal articles | 2015
    Professor Peter Ian Croucher
    Junankar S; Shay G; Jurczyluk J; Ali N; Down J; Pocock N; Parker A; Nguyen A; Sun S; Kashemirov B; McKenna CE; Croucher PI; Swarbrick A; Weilbaecher K; Phan TG; Rogers MJ, 2015, 'Real-Time Intravital Imaging Establishes Tumor-Associated Macrophages as the Extraskeletal Target of Bisphosphonate Action in Cancer', Cancer Discovery, vol. 5, pp. 35 - 42, http://dx.doi.org/10.1158/2159-8290.CD-14-0621
    Journal articles | 2015
    Professor Peter Ian Croucher
    Gascoyne DM; Spearman H; Lyne L; Puliyadi R; Perez-Alcantara M; Coulton L; Fisher SE; Croucher PI; Banham AH, 2015, 'The forkhead transcription factor FOXP2 is required for regulation of p21waf1/cip1 in 143B osteosarcoma cell growth arrest', PLoS ONE, vol. 10, http://dx.doi.org/10.1371/journal.pone.0128513
    Journal articles | 2015
    Professor Peter Ian Croucher
    Esapa CT; Hannan FM; Babinsky VN; Potter P; Thomas GP; Croucher PI; Brown MA; Brown SDM; Cox RD; Thakker RV, 2015, 'N-ethyl-N-nitrosourea (ENU) induced mutations within the Klotho gene lead to ectopic calcification and reduced lifespan in mouse models', PLoS ONE, vol. 10, http://dx.doi.org/10.1371/journal.pone.0122650
    Journal articles | 2015
    Professor Peter Ian Croucher
    Lawson MA; McDonald MM; Kovacic N; Khoo WH; Terry RL; Down J; Kaplan W; Paton-Hough J; Fellows C; Pettitt JA; Dear TN; Van Valckenborgh E; Baldock PA; Rogers MJ; Eaton CL; Vanderkerken K; Pettit AR; Quinn JMW; Zannettino ACW; Phan TG; Croucher PI, 2015, 'Osteoclasts control reactivation of dormant myeloma cells by remodelling the endosteal niche', Nature Communications, vol. 6, http://dx.doi.org/10.1038/ncomms9983
    Journal articles | 2015
    Professor Peter Ian Croucher
    Wang N; Reeves KJ; Brown HK; Fowles ACM; Docherty FE; Ottewell PD; Croucher PI; Holen I; Eaton CL, 2015, 'The frequency of osteolytic bone metastasis is determined by conditions of the soil, not the number of seeds; evidence from in vivo models of breast and prostate cancer', Journal of Experimental and Clinical Cancer Research, vol. 34, http://dx.doi.org/10.1186/s13046-015-0240-8
    Journal articles | 2015
    Professor Peter Ian Croucher
    Wang N; Docherty F; Brown HK; Reeves K; Fowles A; Lawson M; Ottewell PD; Holen I; Croucher PI; Eaton CL, 2015, 'Mitotic quiescence, but not unique "stemness," marks the phenotype of bone metastasis-initiating cells in prostate cancer', FASEB Journal, vol. 29, pp. 3141 - 3150, http://dx.doi.org/10.1096/fj.14-266379
    Journal articles | 2015
    Professor Peter Ian Croucher
    Croucher PI; Parker BS; Corcoran N; Rogers MJ, 2015, 'Bone turnover markers and prostate cancer: Not just a measure of bone disease?', European Urology, vol. 68, pp. 51 - 52, http://dx.doi.org/10.1016/j.eururo.2014.10.041
    Journal articles | 2015
    Professor Peter Ian Croucher
    Ottewell PD; Wang N; Brown HK; Fowles CA; Croucher PI; Eaton CL; Holen I, 2015, 'OPG-Fc inhibits ovariectomy-induced growth of disseminated breast cancer cells in bone', International Journal of Cancer, vol. 137, pp. 968 - 977, http://dx.doi.org/10.1002/ijc.29439
    Journal articles | 2015
    Professor Peter Ian Croucher
    Bassett JHD; Van Der Spek A; Logan JG; Gogakos A; Bagchi-Chakraborty J; Murphy E; Van Zeijl C; Down J; Croucher PI; Boyde A; Boelen A; Williams GR, 2015, 'Thyrostimulin regulates osteoblastic bone formation during early skeletal development', Endocrinology, vol. 156, pp. 3098 - 3113, http://dx.doi.org/10.1210/en.2014-1943
    Journal articles | 2014
    Professor Peter Ian Croucher
    Ottewell PD; Wang N; Brown HK; Reeves KJ; Fowles CA; Croucher PI; Eaton CL; Holen I, 2014, 'Zoledronic acid has differential antitumor activity in the pre- and postmenopausal bone microenvironment in vivo', Clinical Cancer Research, vol. 20, pp. 2922 - 2932, http://dx.doi.org/10.1158/1078-0432.CCR-13-1246
    Journal articles | 2014
    Professor Peter Ian Croucher
    Kassen D; Moore S; Percy L; Herledan G; Bounds D; Rodriguez-Justo M; Croucher P; Yong KL, 2014, 'The bone marrow stromal compartment in multiple myeloma patients retains capability for osteogenic differentiation in vitro: Defining the stromal defect in myeloma', British Journal of Haematology, vol. 167, pp. 194 - 206, http://dx.doi.org/10.1111/bjh.13020
    Journal articles | 2014
    Professor Peter Ian Croucher
    Duncan Bassett JH; Boyde A; Zikmund T; Evans H; Croucher PI; Zhu X; Park JW; Cheng SY; Williams GR, 2014, 'Thyroid hormone receptor α mutation causes a severe and thyroxine-resistant skeletal dysplasia in female mice', Endocrinology, vol. 155, pp. 3699 - 3712, http://dx.doi.org/10.1210/en.2013-2156
    Journal articles | 2014
    Professor Peter Ian Croucher
    Kovacic N; Croucher PI; McDonald MM, 2014, 'Signaling Between Tumor Cells and the Host Bone Marrow Microenvironment', Calcified Tissue International, vol. 94, pp. 125 - 139, http://dx.doi.org/10.1007/s00223-013-9794-7
    Journal articles | 2014
    Professor Peter Ian Croucher
    Wang N; Docherty FE; Brown HK; Reeves KJ; Fowles ACM; Ottewell PD; Dear TN; Holen I; Croucher PI; Eaton CL, 2014, 'Prostate cancer cells preferentially home to osteoblast-rich areas in the early stages of bone metastasis: Evidence from in vivo models', Journal of Bone and Mineral Research, vol. 29, pp. 2688 - 2696, http://dx.doi.org/10.1002/jbmr.2300
    Journal articles | 2014
    Professor Peter Ian Croucher
    Ottewell PD; Wang N; Meek J; Fowles CA; Croucher PI; Eaton CL; Holen I, 2014, 'Castration-induced bone loss triggers growth of disseminated prostate cancer cells in bone', Endocrine-Related Cancer, vol. 21, pp. 769 - 781, http://dx.doi.org/10.1530/ERC-14-0199
    Journal articles | 2014
    Professor Peter Ian Croucher
    Bentley L; Esapa CT; Nesbit MA; Head RA; Evans H; Lath D; Scudamore CL; Hough TA; Podrini C; Hannan FM; Fraser WD; Croucher PI; Brown MA; Brown SDM; Cox RD; Thakker RV, 2014, 'An N-ethyl-n-nitrosourea induced corticotropin-releasing hormone promoter mutation provides a mouse model for endogenous glucocorticoid excess', Endocrinology, vol. 155, pp. 908 - 922, http://dx.doi.org/10.1210/en.2013-1247
    Journal articles | 2014
    Professor Peter Ian Croucher
    Bassett JHD; Boyde A; Zikmund T; Evans H; Croucher PI; Zhu X; Park JW; Cheng S-Y; Williams GR, 2014, 'TR[alpha] mutation causes a severe and thyroxine-resistant skeletal dysplasia', Endocrine Abstracts, http://dx.doi.org/10.1530/endoabs.34.oc4.3
    Journal articles | 2013
    Professor Peter Ian Croucher
    Xu S; De Veirman K; Evans H; Santini GC; Vande Broek I; Leleu X; De Becker A; Van Camp B; Croucher P; Vanderkerken K; Van Riet I, 2013, 'Effect of the HDAC inhibitor vorinostat on the osteogenic differentiation of mesenchymal stem cells in vitro and bone formation in vivo', Acta Pharmacologica Sinica, vol. 34, pp. 699 - 709, http://dx.doi.org/10.1038/aps.2012.182
    Journal articles | 2013
    Professor Peter Ian Croucher
    Buckle C; Faraahi Z; Lawson M; Eaton C; Vanderkerken K; Croucher P, 2013, 'A novel antagonist of the canonical Wnt-signalling pathway, Sostdc1, is expressed in experimental models of myeloma and suppresses bone formation', Bone Abstracts, http://dx.doi.org/10.1530/boneabs.1.pp159
    Journal articles | 2013
    Professor Peter Ian Croucher
    Bentley L; Esapa CT; Nesbit MA; Head RA; Evans H; Lath D; Hough TA; Podrini C; Fraser WD; Croucher PI; Brown MA; Brown SDM; Cox RD; Thakker RV, 2013, 'An N-ethyl-N-nitrosourea induced Corticotrophin releasing hormone promoter mutation provides a mouse model of Cushing's syndrome', Endocrine Abstracts, pp. 1 - 1, http://dx.doi.org/10.1530/endoabs.31.oc2.6
    Journal articles | 2012
    Professor Peter Ian Croucher
    Xu S; Evans H; Buckle C; De Veirman K; Hu J; Xu D; Menu E; De Becker A; Vande Broek I; Leleu X; Camp BV; Croucher P; Vanderkerken K; Van Riet I, 2012, 'Impaired osteogenic differentiation of mesenchymal stem cells derived from multiple myeloma patients is associated with a blockade in the deactivation of the Notch signaling pathway', Leukemia, vol. 26, pp. 2546 - 2549, http://dx.doi.org/10.1038/leu.2012.126
    Journal articles | 2012
    Professor Peter Ian Croucher
    Esapa CT; Bassett JHD; Evans H; Croucher PI; Williams GR; Thakker RV, 2012, 'Bone Mineral Content and Density.', Curr Protoc Mouse Biol, vol. 2, pp. 365 - 400, http://dx.doi.org/10.1002/9780470942390.mo120124
    Journal articles | 2012
    Professor Peter Ian Croucher
    Karunaratne A; Esapa CR; Hiller J; Boyde A; Head R; Bassett JHD; Terrill NJ; Williams GR; Brown MA; Croucher PI; Brown SDM; Cox RD; Barber AH; Thakker RV; Gupta HS, 2012, 'Significant deterioration in nanomechanical quality occurs through incomplete extrafibrillar mineralization in rachitic bone: Evidence from in-situ synchrotron X-ray scattering and backscattered electron imaging', Journal of Bone and Mineral Research, vol. 27, pp. 876 - 890, http://dx.doi.org/10.1002/jbmr.1495
    Journal articles | 2012
    Professor Peter Ian Croucher
    Esapa CT; Hough TA; Testori S; Head RA; Crane EA; Chan CPS; Evans H; Bassett JHD; Tylzanowski P; McNally EG; Carr AJ; Boyde A; Howell PGT; Clark A; Williams GR; Brown MA; Croucher PI; Nesbit MA; Brown SDM; Cox RD; Cheeseman MT; Thakker RV, 2012, 'A mouse model for spondyloepiphyseal dysplasia congenita with secondary osteoarthritis due to a Col2a1 mutation', Journal of Bone and Mineral Research, vol. 27, pp. 413 - 428, http://dx.doi.org/10.1002/jbmr.547
    Journal articles | 2012
    Professor Peter Ian Croucher
    Vitovski S; Chantry AD; Lawson MA; Croucher PI, 2012, 'Targeting tumour-initiating cells with TRAIL based combination therapy ensures complete and lasting eradication of multiple myeloma tumours in vivo', PLoS One, vol. 7, pp. e35830, http://dx.doi.org/10.1371/journal.pone.0035830
    Journal articles | 2012
    Professor Peter Ian Croucher
    Bassett JHD; Gogakos A; White J; Evans HR; Jacques RM; Spek PVD; Ramirez-solis R; Ryder EJ; Sunter D; Boyde A; Campbell MJ; Croucher PI; Williams GR, 2012, 'Rapid-throughput skeletal phenotyping of 100 knockout mice identifies 9 new genes that determine bone strength', PLoS Genetics, vol. 8, pp. e1002858, http://dx.doi.org/10.1371/journal.pgen.1002858
    Journal articles | 2012
    Professor Peter Ian Croucher
    Baud''huin M; Solban N; Cornwall-Brady M; Sako D; Kawamoto Y; Liharska K; Lath D; Bouxsein ML; Underwood KW; Ucran JA; Kumar RSP; Pobre EG; Grinberg AV; Seehra JS; Canalis EM; Pearsall RS; Croucher PI, 2012, 'A soluble bone morphogenetic protein type IA receptor increases bone mass and bone strength', Proceedings of the National Academy of Sciences of the United States of America, vol. 109, pp. 12207 - 12212, http://dx.doi.org/10.1073/pnas.1204929109
    Journal articles | 2012
    Professor Peter Ian Croucher
    Buckle CH; De Leenheer E; Lawson MA; Yong K; Rabin N; Perry M; Vanderkerken K; Croucher PI, 2012, 'Soluble rank ligand produced by myeloma cells causes generalised bone loss in multiple myeloma', PLoS One, vol. 7, pp. e41127, http://dx.doi.org/10.1371/journal.pone.0041127
    Journal articles | 2012
    Professor Peter Ian Croucher
    Bassett JHD; Logan JG; Boyde A; Cheung MS; Evans HR; Croucher P; Sun XY; Xu S; Murata Y; Williams GR, 2012, 'Mice lacking the calcineurin inhibitor Rcan2 have an isolated defect of osteoblast function', Endocrinology, vol. 153, pp. 3537 - 3548, http://dx.doi.org/10.1210/en.2011-1814
    Journal articles | 2012
    Professor Peter Ian Croucher
    Piret SE; Esapa C; Gorvin CM; Head R; Loh NY; Devuyst O; Thomas GP; Brown S; Brown M; Croucher PI; Cox R; Thakker RV, 2012, 'A mouse model of early-onset renal failure due to a xanthine dehydrogenase nonsense mutation', PLoS One, vol. 7, pp. e45217, http://dx.doi.org/10.1371/journal.pone.0045217
    Journal articles | 2012
    Professor Peter Ian Croucher
    Esapa C; Head R; Jeyabalan J; Evans HR; Hough TA; Cheeseman M; Mcnally EG; Carr A; Thomas GP; Brown M; Croucher PI; Brown S; Cox R, 2012, 'A mouse with an N-Ethyl-N-Nitrosourea (ENU) induced Trp589Arg Galnt3 mutation represents a model for hyperphosphataemic familial tumoural calcinosis', PLoS One, vol. 7, pp. e43205, http://dx.doi.org/10.1371/journal.pone.0043205
    Journal articles | 2012
    Professor Peter Ian Croucher
    Chantry AD; Heath D; Mulivor AW; Pearsall S; Baud'Huin M; Coulton L; Evans H; Abdul N; Werner ED; Bouxsein ML; Key ML; Seehra J; Arnett TR; Vanderkerken K; Croucher P, 2012, 'Erratum: Inhibiting activin-A signaling stimulates bone formation and prevents cancer-induced bone destruction in vivo (Journal of Bone and Mineral Research (2010) 25:12 (2633-2646) DOI:10.1002/jbmr.142)', Journal of Bone and Mineral Research, vol. 27, pp. 2036 - 2037, http://dx.doi.org/10.1002/jbmr.1705
    Journal articles | 2012
    Professor Peter Ian Croucher
    Chantry AD; Heath D; Mulivor AW; Pearsall S; Baud'huin M; Coulton L; Evans H; Abdul N; Werner ED; Bouxsein ML; Key ML; Seehra J; Arnett TR; Vanderkerken K; Croucher P, 2012, 'Erratum: Inhibiting activin-A signaling stimulates bone formation and prevents cancer-induced bone destruction in vivo', Journal of Bone and Mineral Research, vol. 27, pp. 2038 - 2038, http://dx.doi.org/10.1002/jbmr.1704
    Journal articles | 2011
    Professor Peter Ian Croucher
    Fowler JA; Edwards CM; Croucher PI, 2011, 'Tumor-host cell interactions in the bone disease of myeloma', Bone, vol. 48, pp. 121 - 128, http://dx.doi.org/10.1016/j.bone.2010.06.029
    Journal articles | 2011
    Professor Peter Ian Croucher
    Felber K; Croucher P; Roehl HH, 2011, 'Hedgehog signalling is required for perichondral osteoblast differentiation in zebrafish', Mechanisms of Development, vol. 128, pp. 141 - 152, http://dx.doi.org/10.1016/j.mod.2010.11.006
    Journal articles | 2011
    Professor Peter Ian Croucher
    Clézardin P; Benzaïd I; Croucher PI, 2011, 'Bisphosphonates in preclinical bone oncology', Bone, vol. 49, pp. 66 - 70, http://dx.doi.org/10.1016/j.bone.2010.11.017
    Journal articles | 2011
    Professor Peter Ian Croucher
    Gambardella A; Nagaraju CK; O'Shea PJ; Mohanty ST; Kottam L; Pilling J; Sullivan M; Djerbi M; Koopmann W; Croucher PI; Bellantuono I, 2011, 'Glycogen synthase kinase-3α/β inhibition promotes in vivo amplification of endogenous mesenchymal progenitors with osteogenic and adipogenic potential and their differentiation to the osteogenic lineage', Journal of Bone and Mineral Research, vol. 26, pp. 811 - 821, http://dx.doi.org/10.1002/jbmr.266
    Journal articles | 2011
    Professor Peter Ian Croucher
    Williams* AJ; Lawson MA; Alamer O; Hough J; Bos T; Vanderkerken K; Croucher PI, 2011, 'Multiphoton imaging of individual myeloma cells in calvariae: Association of myeloma development with sites of bone turnover', Bone, vol. 48, pp. S14 - S14, http://dx.doi.org/10.1016/j.bone.2010.10.037
    Journal articles | 2011
    Professor Peter Ian Croucher
    Kassen D; Rabin N; Lath D; Croucher P; Yong K, 2011, 'Deregulation of the bone marrow stromal compartment occurs early in multiple myeloma and precedes osteolytic bone disease', Bone, vol. 48, pp. S253 - S254, http://dx.doi.org/10.1016/j.bone.2011.03.619
    Journal articles | 2011
    Professor Peter Ian Croucher
    Vitovski* S; Chantry AD; Lawson MA; Croucher PI, 2011, 'Targeting tumour-initiating cells with trail based combination therapy ensures complete and lasting eradication of multiple myeloma tumours in vivo', Bone, vol. 48, pp. S15 - S15, http://dx.doi.org/10.1016/j.bone.2010.10.040
    Journal articles | 2011
    Professor Peter Ian Croucher
    Kassen* D; Rabin N; Lath D; Croucher PI; Yong K, 2011, 'Mechanisms of osteoblast supression in multiple myeolma', Bone, vol. 48, pp. S37 - S37, http://dx.doi.org/10.1016/j.bone.2010.10.103
    Journal articles | 2011
    Professor Peter Ian Croucher
    Buckle* C; Andersen T; Delaisse J-M; Vanderkerken K; Croucher PI, 2011, 'Laser-capture micro-dissection and gene array analysis to identify new molecules implicated in the development of myeloma bone disease', Bone, vol. 48, pp. S19 - S19, http://dx.doi.org/10.1016/j.bone.2010.10.049
    Journal articles | 2010
    Professor Peter Ian Croucher
    Kovacic N; Grcevic D; Katavic V; Lukic IK; Grubisic V; Mihovilovic K; Cvija H; Croucher PI; Marusic A, 2010, 'Fas receptor is required for estrogen deficiency-induced bone loss in mice', Laboratory Investigation, vol. 90, pp. 402 - 413, http://dx.doi.org/10.1038/labinvest.2009.144
    Journal articles | 2010
    Professor Peter Ian Croucher
    Li N; Kelsh RN; Croucher P; Roehl HH, 2010, 'Regulation of neural crest cell fate by the retinoic acid and Pparg signalling pathways', Development, vol. 137, pp. 389 - 394, http://dx.doi.org/10.1242/dev.044164
    Journal articles | 2010
    Professor Peter Ian Croucher
    Mohanty ST; Kottam L; Gambardella A; Nicklin MJ; Coulton L; Hughes D; Wilson AG; Croucher PI; Bellantuono I, 2010, 'Alterations in the self-renewal and differentiation ability of bone marrow mesenchymal stem cells in a mouse model of rheumatoid arthritis', Arthritis Research and Therapy, vol. 12, http://dx.doi.org/10.1186/ar3098
    Journal articles | 2010
    Professor Peter Ian Croucher
    Chantry AD; Heath D; Mulivor AW; Pearsall S; Baud'Huin M; Coulton L; Evans H; Abdul N; Werner ED; Bouxsein ML; Key ML; Seehra J; Arnett TR; Vanderkerken K; Croucher P, 2010, 'Inhibiting activin-A signaling stimulates bone formation and prevents cancer-induced bone destruction in vivo', Journal of Bone and Mineral Research, vol. 25, pp. 2633 - 2646, http://dx.doi.org/10.1002/jbmr.142
    Journal articles | 2010
    Professor Peter Ian Croucher
    Grčević D; Kušec R; Kovačić N; Lukić A; Lukić IK; Ivčević S; Nemet D; Seiwerth RS; Ostojić SK; Croucher PI; Marušić A, 2010, 'Bone morphogenetic proteins and receptors are over-expressed in bone-marrow cells of multiple myeloma patients and support myeloma cells by inducing ID genes', Leukemia Research, vol. 34, pp. 742 - 751, http://dx.doi.org/10.1016/j.leukres.2009.10.016
    Journal articles | 2010
    Professor Peter Ian Croucher
    Bassett JHD; Boyde A; Howell PGT; Bassett RH; Galliford TM; Archanco M; Evans H; Lawson MA; Croucher P; St. Germain DL; Galton VA; Williams GR, 2010, 'Optimal bone strength and mineralization requires the type 2 iodothyronine deiodinase in osteoblasts', Proceedings of the National Academy of Sciences of the United States of America, vol. 107, pp. 7604 - 7609, http://dx.doi.org/10.1073/pnas.0911346107
    Journal articles | 2010
    Professor Peter Ian Croucher
    Coleman RE; Lipton A; Roodman GD; Guise TA; Boyce BF; Brufsky AM; Clézardin P; Croucher PI; Gralow JR; Hadji P; Holen I; Mundy GR; Smith MR; Suva LJ, 2010, 'Metastasis and bone loss: Advancing treatment and prevention', Cancer Treatment Reviews, vol. 36, pp. 615 - 620, http://dx.doi.org/10.1016/j.ctrv.2010.04.003
    Journal articles | 2010
    Professor Peter Ian Croucher
    Lawson MA; Ashcroft J; Croucher PI, 2010, 'Bisphosphonate therapy in the treatment of multiple myeloma', Current Pharmaceutical Design, vol. 16, pp. 3028 - 3036, http://dx.doi.org/10.2174/138161210793563608
    Journal articles | 2010
    Professor Peter Ian Croucher
    Buckle CH; Neville-Webbe HL; Croucher PI; Lawson MA, 2010, 'Targeting RANK/RANKL in the treatment of solid tumours and myeloma', Current Pharmaceutical Design, vol. 16, pp. 1272 - 1283, http://dx.doi.org/10.2174/138161210791034021
    Journal articles | 2010
    Professor Peter Ian Croucher
    Kassen D; Rabin N; Lath D; Croucher P; Yong K, 2010, 'The Effect of Myeloma Cells on Bone Homeostasis Is Heterogenous and Correlates with Underlying Genetic Lesions and Bone Disease In Vivo', Blood, vol. 116, pp. 4052 - 4052, http://dx.doi.org/10.1182/blood.v116.21.4052.4052
    Journal articles | 2009
    Professor Peter Ian Croucher
    Terpos E; Sezer O; Croucher PI; García-Sanz R; Boccadoro M; San Miguel J; Ashcroft J; Bladé J; Cavo M; Delforge M; Dimopoulos MA; Facon T; Macro M; Waage A; Sonneveld P, 2009, 'The use of bisphosphonates in multiple myeloma: Recommendations of an expert panel on behalf of the European Myeloma Network', Annals of Oncology, vol. 20, pp. 1303 - 1317, http://dx.doi.org/10.1093/annonc/mdn796
    Journal articles | 2009
    Professor Peter Ian Croucher
    Deleu S; Lemaire M; Arts J; Menu E; Van Valckenborgh E; Broek IV; De Raeve H; Coulton L; Van Camp B; Croucher P; Vanderkerken K, 2009, 'Bortezomib alone or in combination with the histone deacetylase inhibitor JNJ-26481585: Effect on myeloma bone disease in the 5T2MM murine model of myeloma', Cancer Research, vol. 69, pp. 5307 - 5311, http://dx.doi.org/10.1158/0008-5472.CAN-08-4472
    Journal articles | 2009
    Professor Peter Ian Croucher
    Deleu S; Lemaire M; Arts J; Menu E; Van Valckenborgh E; King P; Vande Broek I; De Raeve H; Van Camp B; Croucher P; Vanderkerken K, 2009, 'The effects of JNJ-26481585, a novel hydroxamate-based histone deacetylase inhibitor, on the development of multiple myeloma in the 5T2MM and 5T33MM murine models', Leukemia, vol. 23, pp. 1894 - 1903, http://dx.doi.org/10.1038/leu.2009.121
    Journal articles | 2009
    Professor Peter Ian Croucher
    Li N; Felber K; Elks P; Croucher P; Roehl HH, 2009, 'Tracking gene expression during zebrafish osteoblast differentiation', Developmental Dynamics, vol. 238, pp. 459 - 466, http://dx.doi.org/10.1002/dvdy.21838
    Journal articles | 2009
    Professor Peter Ian Croucher
    Heath DJ; Chantry AD; Buckle CH; Coulton L; Shaughnessy JD; Evans HR; Snowden JA; Stover DR; Vanderkerken K; Croucher PI, 2009, 'Inhibiting dickkopf-1 (Dkkl) removes suppression of bone formation and prevents the development of osteolytic bone disease in multiple myeloma', Journal of Bone and Mineral Research, vol. 24, pp. 425 - 436, http://dx.doi.org/10.1359/jbmr.081104
    Journal articles | 2009
    Professor Peter Ian Croucher
    Li N; Felber K; Elks P; Croucher P; Roehl HH, 2009, 'Tracking gene expression during zebrafish osteoblast differentiation', Developmental Dynamics, vol. 238, pp. spcone - spcone, http://dx.doi.org/10.1002/dvdy.21904
    Journal articles | 2009
    Professor Peter Ian Croucher
    Hald A; Hansen RR; Thomsen MW; Ding M; Croucher PI; Gallagher O; Ebetino FH; Kassem M; Heegaard AM, 2009, 'Cancer-induced bone loss and associated pain-related behavior is reduced by risedronate but not its phosphonocarboxylate analog NE-10790', International Journal of Cancer, vol. 125, pp. 1177 - 1185, http://dx.doi.org/10.1002/ijc.24436
    Journal articles | 2009
    Professor Peter Ian Croucher
    Brown SDM; Esapa CT; Barbaric I; Hough T; Brown M; Croucher P; Head R; Chan C; Crane E; Cox R; Cheeseman M; Thakker RV, 2009, 'Genetic models of bone disease using ENU mutagenesis', Bone, vol. 44, pp. S19 - S19, http://dx.doi.org/10.1016/j.bone.2009.01.041
    Journal articles | 2009
    Professor Peter Ian Croucher
    Buckle CH; De Leenheer E; Lawson MA; Hough JM; Yong KL; Rabin N; Vanderkerken K; Croucher PI, 2009, 'Soluble RANK ligand produced by myeloma cells contributes to generalised bone loss in multiple myeloma', Bone, vol. 44, pp. S162 - S162, http://dx.doi.org/10.1016/j.bone.2009.01.458
    Journal articles | 2009
    Professor Peter Ian Croucher
    Deleu SI; Arts J; Lemaire M; Menu E; Van Valckenborgh E; De Raeve H; Croucher P; Van Camp B; Vanderkerken K, 2009, 'B144 The Effect of JNJ-26481585 in Murine Myeloma Models', Clinical Lymphoma and Myeloma, vol. 9, pp. S104 - S104, http://dx.doi.org/10.1016/s1557-9190(11)70664-3
    Journal articles | 2009
    Professor Peter Ian Croucher
    Chantry A; Coulton L; Gallagher O; Evans H; Seehra J; Pearsall S; De Raeve H; Vanderkerken K; Croucher P, 2009, 'Blockade of the ALK1 receptor reduces tumour microvessel density and prevents the formation of osteolytic bone disease in the 5T2MM murine model of myeloma', Bone, vol. 44, pp. S55 - S55, http://dx.doi.org/10.1016/j.bone.2009.01.465
    Journal articles | 2009
    Professor Peter Ian Croucher
    Abdul N; Stoop W; Koopman W; Djerbi M; Chantry AD; Evans H; Vanderkerken K; Croucher PI, 2009, 'Inhibiting glycogen synthase kinase-3 (GSK-3) prevents the development of myeloma bone disease', Bone, vol. 44, pp. S53 - S54, http://dx.doi.org/10.1016/j.bone.2009.01.462
    Journal articles | 2009
    Professor Peter Ian Croucher
    Felber K; Elks P; Croucher P; Roehl H, 2009, '13-P049 FGF signalling is regulating bone development in zebrafish', Mechanisms of Development, vol. 126, pp. S209 - S209, http://dx.doi.org/10.1016/j.mod.2009.06.522
    Journal articles | 2009
    Professor Peter Ian Croucher
    Lawson MA; Williams AJ; Bos T; Vanderkerken K; Croucher PI, 2009, 'Localising individual myeloma cells to the myeloma ‘niche’ in bone using multiphoton microscopy', Bone, vol. 44, pp. S164 - S164, http://dx.doi.org/10.1016/j.bone.2009.01.384
    Journal articles | 2009
    Professor Peter Ian Croucher
    Feng R; Huang X; Coulton L; Raeve HD; DiLiberto M; Ely S; Xiao G; Luo M; Menu E; Croucher P; Roodman GD; Vanderkerken K; Chen-Kiang S; Lentzsch S, 2009, 'Targeting CDK4/CDK6 Impairs Osteoclast Progenitor Pool Expansion and Blocks Osteolytic Lesion Development in Multiple Myeloma.', Blood, vol. 114, pp. 298 - 298, http://dx.doi.org/10.1182/blood.v114.22.298.298
    Journal articles | 2008
    Professor Peter Ian Croucher
    Lawson MA; Coulton L; Ebetino FH; Vanderkerken K; Croucher PI, 2008, 'Geranylgeranyl transferase type II inhibition prevents myeloma bone disease', Biochemical and Biophysical Research Communications, vol. 377, pp. 453 - 457, http://dx.doi.org/10.1016/j.bbrc.2008.09.157
    Journal articles | 2008
    Professor Peter Ian Croucher
    Terpos E; Kastritis E; Roussou M; Heath D; Christoulas D; Anagnostopoulos N; Eleftherakis-Papaiakovou E; Tsionos K; Croucher P; Dimopoulos MA, 2008, 'The combination of bortezomib, melphalan, dexamethasone and intermittent thalidomide is an effective regimen for relapsed/refractory myeloma and is associated with improvement of abnormal bone metabolism and angiogenesis', Leukemia, vol. 22, pp. 2247 - 2256, http://dx.doi.org/10.1038/leu.2008.235
    Journal articles | 2008
    Professor Peter Ian Croucher
    Lawrie A; Waterman E; Southwood M; Evans D; Suntharalingam J; Francis S; Crossman D; Croucher P; Morrell N; Newman C, 2008, 'Evidence of a role for osteoprotegerin in the pathogenesis of pulmonary arterial hypertension', American Journal of Pathology, vol. 172, pp. 256 - 264, http://dx.doi.org/10.2353/ajpath.2008.070395
    Journal articles | 2008
    Professor Peter Ian Croucher
    Heath D; Chantry A; Buckle C; Coulton L; Shaughnessy J; Evans H; Stover D; Vanderkerken K; Croucher P, 2008, 'OC7. Inhibiting dickkopf-1 (Dkk-1) prevents the development of osteolytic bone disease in multiple myeloma', Cancer Treatment Reviews, vol. 34, pp. 52 - 52, http://dx.doi.org/10.1016/j.ctrv.2008.03.033
    Journal articles | 2008
    Professor Peter Ian Croucher
    Ottewell P; Croucher P; Holen I, 2008, 'P1. Breast cancer cells cause a reduction in osteoblast number – An early event in the development of osteolytic bone lesions', Cancer Treatment Reviews, vol. 34, pp. 12 - 12, http://dx.doi.org/10.1016/j.ctrv.2008.03.042
    Journal articles | 2008
    Professor Peter Ian Croucher
    Chantry A; Heath D; Coulton L; Evans H; Abdul N; Seehra J; Vanderkerken K; Croucher P, 2008, 'P3. A soluble activin type II receptor prevents the development of myeloma bone disease', Cancer Treatment Reviews, vol. 34, pp. 13 - 14, http://dx.doi.org/10.1016/j.ctrv.2008.03.044
    Journal articles | 2008
    Professor Peter Ian Croucher
    Terpos E; Kastritis E; Roussou M; Heath D; Christoulas D; Anagnostopoulos N; Eleftherakis-Papaiakovou E; Tsionos K; Croucher P; Dimopoulos MA, 2008, 'Erratum: The combination of bortezomib, melphalan, dexamethasone and intermittent thalidomide is an effective regimen for relapsed/refractory myeloma and is associated with improvement of abnormal bone metabolism and angiogenesis (Leukemia (2008) vol. 22 (2247-2256) 10.1038/ leu.2008.2256)', Leukemia, vol. 22, pp. 2292, http://dx.doi.org/10.1038/leu.2008.288
    Journal articles | 2007
    Professor Peter Ian Croucher
    Heath DJ; Vanderkerken K; Cheng X; Gallagher O; Prideaux M; Murali R; Croucher PI, 2007, 'An osteoprotegerin-like peptidomimetic inhibits osteoclastic bone resorption and osteolytic bone disease in myeloma', Cancer Research, vol. 67, pp. 202 - 208, http://dx.doi.org/10.1158/0008-5472.CAN-06-1287
    Journal articles | 2007
    Professor Peter Ian Croucher
    Terpos E; Sezer O; Croucher P; Dimopoulos MA, 2007, 'Myeloma bone disease and proteasome inhibition therapies', Blood, vol. 110, pp. 1098 - 1104, http://dx.doi.org/10.1182/blood-2007-03-067710
    Journal articles | 2007
    Professor Peter Ian Croucher
    Vitovski S; Phillips JS; Sayers J; Croucher PI, 2007, 'Investigating the interaction between osteoprotegerin and receptor activator of NF-κB or tumor necrosis factor-related apoptosis-inducing ligand: Evidence for a pivotal role for osteoprotegerin in regulating two distinct pathways', Journal of Biological Chemistry, vol. 282, pp. 31601 - 31609, http://dx.doi.org/10.1074/jbc.M706078200
    Journal articles | 2007
    Professor Peter Ian Croucher
    Vanderkerken K; Medicherla S; Coulton L; De Raeve H; Willems A; Lawson M; Van Camp B; Protter AA; Higgins LS; Menu E; Croucher PI, 2007, 'Inhibition of p38α mitogen-activated protein kinase prevents the development of osteolytic bone disease, reduces tumor burden, and increases survival in murine models of multiple myeloma', Cancer Research, vol. 67, pp. 4572 - 4577, http://dx.doi.org/10.1158/0008-5472.CAN-06-4361
    Journal articles | 2007
    Professor Peter Ian Croucher
    Kovačić N; Lukić IK; Grčević D; Katavić V; Croucher P; Marušić A, 2007, 'The Fas/Fas ligand system inhibits differentiation of murine osteoblasts but has a limited role in osteoblast and osteoclast apoptosis', Journal of Immunology, vol. 178, pp. 3379 - 3389, http://dx.doi.org/10.4049/jimmunol.178.6.3379
    Journal articles | 2007
    Professor Peter Ian Croucher
    Rabin N; Kyriakou C; Coulton L; Gallagher OM; Buckle C; Benjamin R; Singh N; Glassford J; Otsuki T; Nathwani AC; Croucher PI; Yong KL, 2007, 'A new xenograft model of myeloma bone disease demonstrating the efficacy of human mesenchymal stem cells expressing osteoprotegerin by lentiviral gene transfer', Leukemia, vol. 21, pp. 2181 - 2191, http://dx.doi.org/10.1038/sj.leu.2404814
    Journal articles | 2007
    Professor Peter Ian Croucher
    Menu E; Jernberg-Wiklund H; De Raeve H; De Leenheer E; Coulton L; Gallagher O; Van Valckenborgh E; Larsson O; Axelson M; Nilsson K; Van Camp B; Croucher P; Vanderkerken K, 2007, 'Targeting the IGF-1R using picropodophyllin in the therapeutical 5T2MM mouse model of multiple myeloma: Beneficial effects on tumor growth, angiogenesis, bone disease and survival', International Journal of Cancer, vol. 121, pp. 1857 - 1861, http://dx.doi.org/10.1002/ijc.22845
    Journal articles | 2007
    Professor Peter Ian Croucher
    Locklin RM; Croucher PI; Russell RGG; Edwards CM, 2007, 'Agonists of TRAIL death receptors induce myeloma cell apoptosis that is not prevented by cells of the bone marrow microenvironment', Leukemia, vol. 21, pp. 805 - 812, http://dx.doi.org/10.1038/sj.leu.2404518
    Journal articles | 2007
    Professor Peter Ian Croucher
    Edwards CM; Mueller G; Roelofs AJ; Chantry A; Perry M; Russell RGG; Van Camp B; Guyon-Gellin Y; Niesor EJ; Bentzen CL; Vanderkerken K; Croucher PI, 2007, 'Apomine™, an inhibitor of HMG-CoA-reductase, promotes apoptosis of myeloma cells in vitro and is associated with a modulation of myeloma in vivo', International Journal of Cancer, vol. 120, pp. 1657 - 1663, http://dx.doi.org/10.1002/ijc.22478
    Journal articles | 2007
    Professor Peter Ian Croucher
    Xu J; Leenheer ED; Piasecki J; De Vries A-RV; Vanderkerken K; Croucher P, 2007, 'In Vivo Evaluation of a BAFF Inhibitor AMG 523 Suggests Lack of Efficacy in Multiple Myeloma Tumor Models.', Blood, vol. 110, pp. 1518 - 1518, http://dx.doi.org/10.1182/blood.v110.11.1518.1518
    Journal articles | 2006
    Professor Peter Ian Croucher
    Terpos E; Heath DJ; Rahemtulla A; Zervas K; Chantry A; Anagnostopoulos A; Pouli A; Katodritou E; Verrou E; Vervessou EC; Dimopoulos MA; Croucher PI, 2006, 'Bortezomib reduces serum dickkopf-1 and receptor activator of nuclear factor-κB ligand concentrations and normalises indices of bone remodelling in patients with relapsed multiple myeloma', British Journal of Haematology, vol. 135, pp. 688 - 692, http://dx.doi.org/10.1111/j.1365-2141.2006.06356.x
    Journal articles | 2006
    Professor Peter Ian Croucher
    Karadag A; Zhou M; Croucher PI, 2006, 'ADAM-9 (MDC-9/meltrin-γ), a member of the a disintegrin and metalloproteinase family, regulates myeloma-cell-induced interleukin-6 production in osteoblasts by direct interaction with the α vβ5 integrin', Blood, vol. 107, pp. 3271 - 3278, http://dx.doi.org/10.1182/blood-2005-09-3830
    Journal articles | 2006
    Professor Peter Ian Croucher
    Menu E; De Leenheer E; De Raeve H; Coulton L; Imanishi T; Miyashita K; Van Valckenborgh E; Van Riet I; Van Camp B; Horuk R; Croucher P; Vanderkerken K, 2006, 'Role of CCR1 and CCR5 in homing and growth of multiple myeloma and in the development of osteolytic lesions: A study in the 5TMM model', Clinical and Experimental Metastasis, vol. 23, pp. 291 - 300, http://dx.doi.org/10.1007/s10585-006-9038-6
    Journal articles | 2006
    Professor Peter Ian Croucher
    Politou MC; Heath DJ; Rahemtulla A; Szydlo R; Anagnostopoulos A; Dimopoulos MA; Croucher PI; Terpos E, 2006, 'Serum concentrations of Dickkopf-1 protein are increased in patients with multiple myeloma and reduced after autologous stem cell transplantation', International Journal of Cancer, vol. 119, pp. 1728 - 1731, http://dx.doi.org/10.1002/ijc.22033
    Journal articles | 2006
    Professor Peter Ian Croucher
    Vanderkerken K; Medicherla S; Coulton L; Van Camp B; Protter A; Higgins L; Menu E; Croucher P, 2006, 'Inhibition of p38α MAPK Reduces Tumor Burden, Prevents the Development of Myeloma Bone Disease, and Increases Survival in the 5T2 and 5T33 Murine Models of Myeloma.', Blood, vol. 108, pp. 3436 - 3436, http://dx.doi.org/10.1182/blood.v108.11.3436.3436
    Journal articles | 2006
    Professor Peter Ian Croucher
    Terpos E; Anagnostopoulos A; Heath D; Kastritis E; Christoulas D; Anagnostopoulos N; Roussou M; Tsionos K; Croucher P; Dimopoulos MA, 2006, 'The Combination of Bortezomib, Melphalan, Dexamethasone and Intermittent Thalidomide (VMDT) Is an Effective Regimen for Relapsed/Refractory Myeloma and Reduces Serum Levels of Dickkopf-1, RANKL, MIP-1α and Angiogenic Cytokines.', Blood, vol. 108, pp. 3541 - 3541, http://dx.doi.org/10.1182/blood.v108.11.3541.3541
    Journal articles | 2006
    Professor Peter Ian Croucher
    Terpos E; Heath D; Rahemtulla A; Zervas K; Chantry A; Anagnostopoulos A; Pouli A; Katodritou E; Verrou E; Vervessou EC; Dimopoulos MA; Croucher P, 2006, 'Bortezomib Reduces Serum Dickkopf-1 and RANKL Concentrations and Normalizes Indices of Bone Remodeling in Patients with Relapsed Multiple Myeloma.', Blood, vol. 108, pp. 506 - 506, http://dx.doi.org/10.1182/blood.v108.11.506.506
    Journal articles | 2006
    Professor Peter Ian Croucher
    Rabin N; Kyriakou C; Pizzey A; Buckle C; Prideaux M; Croucher P; Nathwani A; Yong K, 2006, '663. Gene Modified Human Mesenchymal Stem Cells Expressing Osteoprotegerin Reverse Osteoclast Activation in a Xenogeneic Murine Model of Multiple Myeloma', Molecular Therapy, vol. 13, pp. S256 - S256, http://dx.doi.org/10.1016/j.ymthe.2006.08.740
    Journal articles | 2006
    Professor Peter Ian Croucher
    Rabin N; Kyriakou C; Benjamin R; Pizzey A; Gallagher O; Singh N; Buckle C; Croucher P; Nathwani A; Yong K, 2006, 'Gene Modified Human Mesenchymal Stem Cells Expressing Osteoprotegerin Inhibit Osteoclast Activation and Increase Trabecular Bone Area in a Xenogeneic Murine Model of Myeloma.', Blood, vol. 108, pp. 505 - 505, http://dx.doi.org/10.1182/blood.v108.11.505.505
    Journal articles | 2005
    Professor Peter Ian Croucher
    Holen I; Cross SS; Neville-Webbe HL; Cross NA; Balasubramanian SP; Croucher PI; Evans CA; Lippitt JM; Coleman RE; Eaton CL, 2005, 'Osteoprotegerin (OPG) expression by breast cancer cells in vitro and breast tumours in vivo - A role in tumour cell survival?', Breast Cancer Research and Treatment, vol. 92, pp. 207 - 215, http://dx.doi.org/10.1007/s10549-005-2419-8
    Journal articles | 2005
    Professor Peter Ian Croucher
    Vanderkerken K; Asosingh K; Willems A; De Raeve H; Couck P; Gorus F; Croucher P; Van Camp B, 2005, 'The 5T2MM murine model of multiple myeloma: maintenance and analysis.', Methods in molecular medicine, vol. 113, pp. 191 - 205
    Journal articles | 2005
    Professor Peter Ian Croucher
    Kartsogiannis V; Ly C; Zhou H; Gallagher O; Buckle C; De Leenheer E; Vanderkerken K; Ng KW; Martin T; gillespie M; Croucher P, 2005, 'Expression of RANKL, OPG, PTHrP and OCIL in multiple myeloma are influenced by the tumor cells` proximity to bone', Journal of Bone and Mineral Research, vol. 20, pp. S211 - S211
    Journal articles | 2004
    Professor Peter Ian Croucher
    Eaton CL; Wells JM; Holen I; Croucher PI; Hamdy FC, 2004, 'Serum Osteoprotegerin (OPG) Levels Are Associated with Disease Progression and Response to Androgen Ablation in Patients with Prostate Cancer', Prostate, vol. 59, pp. 304 - 310, http://dx.doi.org/10.1002/pros.20016
    Journal articles | 2004
    Professor Peter Ian Croucher
    De Leenheer E; Mueller GS; Vanderkerken K; Croucher PI, 2004, 'Evidence of a role for RANKL in the development of myeloma bone disease', Current Opinion in Pharmacology, vol. 4, pp. 340 - 346, http://dx.doi.org/10.1016/j.coph.2004.03.011
    Journal articles | 2004
    Professor Peter Ian Croucher
    Van Valckenborgh E; Croucher PI; De Raeve H; Carron C; De Leenheer E; Blacher S; Devy L; Noël A; De Bruyne E; Asosingh K; Van Riet I; Van Camp B; Vanderkerken K, 2004, 'Multifunctional role of matrix metalloproteinases in multiple myeloma: A study in the 5T2MM mouse model', American Journal of Pathology, vol. 165, pp. 869 - 878, http://dx.doi.org/10.1016/S0002-9440(10)63349-4
    Journal articles | 2004
    Professor Peter Ian Croucher
    Menu E; Asosingh K; Van Riet I; Croucher P; Van Camp B; Vanderkerken K, 2004, 'Myeloma cells (5TMM) and their interactions with the marrow microenvironment', Blood Cells, Molecules, and Diseases, vol. 33, pp. 111 - 119, http://dx.doi.org/10.1016/j.bcmd.2004.04.012
    Journal articles | 2004
    Professor Peter Ian Croucher
    Croucher PI, 2004, 'The RANKL system and the development of tumor-induced bone disease: Lessons from pre-clinical models', Journal of Musculoskeletal Neuronal Interactions, vol. 4, pp. 285 - 292
    Journal articles | 2003
    Professor Peter Ian Croucher
    Vanderkerken K; Asosingh K; Croucher P; Van Camp B, 2003, 'Multiple myeloma biology: Lessons from the 5TMM models', Immunological Reviews, vol. 194, pp. 196 - 206, http://dx.doi.org/10.1034/j.1600-065X.2003.00035.x
    Journal articles | 2003
    Professor Peter Ian Croucher
    Ashcroft AJ; Cruickshank SM; Croucher PI; Perry MJ; Rollinson S; Lippitt JM; Child JA; Dunstan C; Felsburg PJ; Morgan GJ; Carding SR, 2003, 'Colonic Dendritic Cells, Intestinal Inflammation, and T Cell-Mediated Bone Destruction Are Modulated by Recombinant Osteoprotegerin', Immunity, vol. 19, pp. 849 - 861, http://dx.doi.org/10.1016/S1074-7613(03)00326-1
    Journal articles | 2003
    Professor Peter Ian Croucher
    Croucher PI; De Raeve H; Perry MJ; Hijzen A; Shipman CM; Lippitt J; Green J; Van Marck E; Van Camp B; Vanderkerken K, 2003, 'Zoledronic acid treatment of 5T2MM-bearing mice inhibits the development of myeloma bone disease: Evidence for decreased osteolysis, tumor burden and angiogenesis, and increased survival', Journal of Bone and Mineral Research, vol. 18, pp. 482 - 492, http://dx.doi.org/10.1359/jbmr.2003.18.3.482
    Journal articles | 2003
    Professor Peter Ian Croucher
    Shipman CM; Croucher PI, 2003, 'Osteoprotegerin is a soluble decoy receptor for tumor necrosis factor-related apoptosis-inducing ligand/Apo2 ligand and can function as a paracrine survival factor for human myeloma cells', Cancer Research, vol. 63, pp. 912 - 916
    Journal articles | 2003
    Professor Peter Ian Croucher
    Vanderkerken K; De Leenheer E; Shipman C; Asosingh K; Willems A; Van Camp B; Croucher P, 2003, 'Recombinant osteoprotegerin decreases tumor burden and increases survival in a murine model of multiple myeloma', Cancer Research, vol. 63, pp. 287 - 289
    Journal articles | 2003
    Professor Peter Ian Croucher
    Croucher P; Jagdev S; Coleman R, 2003, 'The anti-tumor potential of zoledronic acid', Breast, vol. 12, http://dx.doi.org/10.1016/S0960-9776(03)80161-3
    Journal articles | 2002
    Professor Peter Ian Croucher
    Holen I; Croucher PI; Hamdy FC; Eaton CL, 2002, 'Osteoprotegerin (OPG) is a survival factor for human prostate cancer cells', Cancer Research, vol. 62, pp. 1619 - 1623
    Journal articles | 2002
    Professor Peter Ian Croucher
    Wells J; Holen I; Croucher P; Hamdy F; Eaton C, 2002, 'Serum osteoprotegerin levels are increased in hormone resistant prostate cancer patients', European Urology Supplements, vol. 1, pp. 159 - 159, http://dx.doi.org/10.1016/s1569-9056(02)80621-2
    Journal articles | 2002
    Professor Peter Ian Croucher
    Holen I; Eaton C; Hamdy F; Croucher P, 2002, 'Production of osteoprotegerin by prostate cancer cells suppresses trial induced apoptosis', European Urology Supplements, vol. 1, pp. 54 - 54, http://dx.doi.org/10.1016/s1569-9056(02)80203-2
    Journal articles | 2001
    Professor Peter Ian Croucher
    Jagdev SP; Coleman RE; Shipman CM; Rostami-H. A; Croucher PI, 2001, 'The bisphosphonate, zoledronic acid, induces apoptosis of breast cancer cells: Evidence for synergy with paclitaxel', British Journal of Cancer, vol. 84, pp. 1126 - 1134, http://dx.doi.org/10.1054/bjoc.2001.1727
    Journal articles | 2001
    Professor Peter Ian Croucher
    Zhou M; Graham R; Russell G; Croucher PI, 2001, 'MDC-9 (adam-9/meltrin γ) functions as an adhesion molecule by binding the αvβ5 integrin', Biochemical and Biophysical Research Communications, vol. 280, pp. 574 - 580, http://dx.doi.org/10.1006/bbrc.2000.4155
    Journal articles | 2001
    Professor Peter Ian Croucher
    Croucher PI; Shipman CM; Lippitt J; Perry M; Asosingh K; Hijzen A; Brabbs AC; Van Beek EJR; Holen I; Skerry TM; Dunstan CR; Russell GR; Van Camp B; Vanderkerken K, 2001, 'Osteoprotegerin inhibits the development of osteolytic bone disease in multiple myeloma', Blood, vol. 98, pp. 3534 - 3540, http://dx.doi.org/10.1182/blood.V98.13.3534
    Journal articles | 2001
    Professor Peter Ian Croucher
    Holen I; Drury NL; Hargreaves PG; Croucher PI, 2001, 'Evidence of a role for a non-matrix-type metalloproteinase activity in the shedding of syndecan-1 from human myeloma cells', British Journal of Haematology, vol. 114, pp. 414 - 421, http://dx.doi.org/10.1046/j.1365-2141.2001.02963.x
    Journal articles | 2001
    Professor Peter Ian Croucher
    Russell G; Mueller G; Shipman C; Croucher P, 2001, 'Clinical disorders of bone resorption.', Novartis Foundation symposium, vol. 232, pp. 251 - 267
    Journal articles | 2001
    Professor Peter Ian Croucher
    Asosingh K; De Raeve H; Croucher P; Goes E; Van Riet I; Van Camp B; Vanderkerken K, 2001, 'In vivo homing and differentiation characteristics of mature (CD45) and immature (CD45+) 5T multiple myeloma cells', Experimental Hematology, vol. 29, pp. 77 - 84, http://dx.doi.org/10.1016/S0301-472X(00)00625-1
    Journal articles | 2001
    Professor Peter Ian Croucher
    Shipman CM; Croucher PI; Vanderkerken K, 2001, 'Reply to salomo and gimsing', British Journal of Haematology, vol. 113, pp. 842 - 842, http://dx.doi.org/10.1046/j.1365-2141.2001.02804-4.x
    Journal articles | 2001
    Professor Peter Ian Croucher
    Salomo M; Gimsing P; Shipman CM; Croucher PI, 2001, 'Bisphosphonates and in vivo models of multiple myeloma [3] (multiple letters)', British Journal of Haematology, vol. 113, pp. 841 - 842, http://dx.doi.org/10.1046/j.1365-2141.2001.02804-3.x
    Journal articles | 2001
    Professor Peter Ian Croucher
    Jagdev SP; Croucher PI; Coleman RE, 2001, 'The effects of intravenous bisphosphonate treatment on the bone microenvironment in patients with breast cancer and bone metastases', European Journal of Cancer, vol. 37, pp. S129 - S129, http://dx.doi.org/10.1016/s0959-8049(01)80965-5
    Journal articles | 2000
    Professor Peter Ian Croucher
    Shipman CM; Vanderkerken K; Rogers MJ; Lippitt JM; Asosingh K; Hughes DE; Van Camp B; Russell RGG; Croucher PI, 2000, 'The potent bisphosphonate ibandronate does not induce myeloma cell apoptosis in a murine model of established multiple myeloma', British Journal of Haematology, vol. 111, pp. 283 - 286, http://dx.doi.org/10.1046/j.1365-2141.2000.02310.x
    Journal articles | 2000
    Professor Peter Ian Croucher
    Karadag A; Oyajobi BO; Apperley JF; Graham R; Russell G; Croucher PI, 2000, 'Human myeloma cells promote the production of interleukin 6 by primary human osteoblasts', British Journal of Haematology, vol. 108, pp. 383 - 390, http://dx.doi.org/10.1046/j.1365-2141.2000.01845.x
    Journal articles | 2000
    Professor Peter Ian Croucher
    Karadag A; Scutt AM; Croucher PI, 2000, 'Human myeloma cells promote the recruitment of osteoblast precursors: Mediation by interleukin-6 and soluble interleukin-6 receptor', Journal of Bone and Mineral Research, vol. 15, pp. 1935 - 1943, http://dx.doi.org/10.1359/jbmr.2000.15.10.1935
    Journal articles | 1999
    Professor Peter Ian Croucher
    Sati HIA; Greaves M; Apperley JF; Russell RGG; Croucher PI, 1999, 'Expression of interleukin-1β and tumour necrosis factor-α in plasma cells from patients with multiple myeloma', British Journal of Haematology, vol. 104, pp. 350 - 357, http://dx.doi.org/10.1046/j.1365-2141.1999.01193.x
    Journal articles | 1999
    Professor Peter Ian Croucher
    Croucher PI; Wang F; Hargreaves PG, 1999, 'Interleukin-6 Receptor (IL-6R) Shedding: A Role for Members of the ADAM Family', Biochemical Society Transactions, vol. 27, pp. A23 - A23, http://dx.doi.org/10.1042/bst027a023a
    Journal articles | 1999
    Professor Peter Ian Croucher
    Apperley JF; Croucher PI, 1999, 'Bisphosphonates in multiple myeloma', Pathologie Biologie, vol. 47, pp. 178 - 181
    Journal articles | 1998
    Professor Peter Ian Croucher
    Shipman CM; Croucher PI; Russell RGG; Helfrich MH; Rogers MJ, 1998, 'The bisphosphonate incadronate (YM175) causes apoptosis of human myeloma cells in vitro by inhibiting the mevalonate pathway', Cancer Research, vol. 58, pp. 5294 - 5297
    Journal articles | 1998
    Professor Peter Ian Croucher
    Sati HIA; Apperley JF; Greaves M; Lawry J; Gooding R; Russell RGG; Croucher PI, 1998, 'Interleukin-6 is expressed by plasma cells from patients with multiple myeloma and monoclonal gammopathy of undetermined significance', British Journal of Haematology, vol. 101, pp. 287 - 295, http://dx.doi.org/10.1046/j.1365-2141.1998.00687.x
    Journal articles | 1998
    Professor Peter Ian Croucher
    Shipman CM; Rogers MJ; Apperley JF; Russell RGG; Croucher PI, 1998, 'Anti-tumour activity of bisphosphonates in human myeloma cells', Leukemia and Lymphoma, vol. 32, pp. 129 - 138, http://dx.doi.org/10.3109/10428199809059253
    Journal articles | 1998
    Professor Peter Ian Croucher
    Croucher PI; Apperley JF, 1998, 'Bone disease in multiple myeloma', British Journal of Haematology, vol. 103, pp. 902 - 910, http://dx.doi.org/10.1046/j.1365-2141.1998.01082.x
    Journal articles | 1998
    Professor Peter Ian Croucher
    Hargreaves PG; Wang F; Antcliff J; Murphy G; Lawry J; Russell RGG; Croucher PI, 1998, 'Human myeloma cells shed the interleukin-6 receptor: Inhibition by tissue inhibitor of metalloproteinase-3 and a hydroxamate-based metalloproteinase inhibitor', British Journal of Haematology, vol. 101, pp. 694 - 702, http://dx.doi.org/10.1046/j.1365-2141.1998.00754.x
    Journal articles | 1997
    Professor Peter Ian Croucher
    Shipman CM; Rogers MJ; Apperley JF; Russell RGG; Croucher PI, 1997, 'Bisphosphonates induce apoptosis in human myeloma cell lines: A novel anti-tumour activity', British Journal of Haematology, vol. 98, pp. 665 - 672, http://dx.doi.org/10.1046/j.1365-2141.1997.2713086.x
    Journal articles | 1997
    Professor Peter Ian Croucher
    McKie N; Edwards T; Dallas DJ; Houghton A; Stringer B; Graham R; Russell G; Croucher PI, 1997, 'Expression of members of a novel membrane linked metalloproteinase family (ADAM) in human articular chondrocytes', Biochemical and Biophysical Research Communications, vol. 230, pp. 335 - 339, http://dx.doi.org/10.1006/bbrc.1996.5957
    Journal articles | 1997
    Professor Peter Ian Croucher
    Wu E; Croucher PI; McKie N, 1997, 'Expression of members of the novel membrane linked metalloproteinase family ADAM in cells derived from a range of haematological malignancies', Biochemical and Biophysical Research Communications, vol. 235, pp. 437 - 442, http://dx.doi.org/10.1006/bbrc.1997.6714
    Journal articles | 1996
    Professor Peter Ian Croucher
    McKie N; Dallas DJ; Edwards T; Apperley JF; Russell RGG; Croucher PI, 1996, 'Cloning of a novel membrane-linked metalloproteinase from human myeloma cells', Biochemical Journal, vol. 318, pp. 459 - 462, http://dx.doi.org/10.1042/bj3180459
    Journal articles | 1996
    Professor Peter Ian Croucher
    Compston JE; Vedi S; Croucher PI; Garrahan NJ, 1996, 'Effects of hormone replacement therapy on cancellous bone microstructure in postmenopausal women', Bone, vol. 19, pp. 136 - 136, http://dx.doi.org/10.1016/s8756-3282(96)90752-8
    Journal articles | 1996
    Professor Peter Ian Croucher
    Vedi S; Croucher PI; Garrahan NJ; Compston JE, 1996, 'Effects of hormone replacement therapy on cancellous bone microstructure in postmenopausal women', Bone, vol. 19, pp. 69 - 72, http://dx.doi.org/10.1016/8756-3282(96)00108-1
    Journal articles | 1994
    Professor Peter Ian Croucher
    Vedi S; Croucher PI; Garrahan NJ; O'Sullivan MM; Compston JE, 1994, 'P3. Bone turnover in non-steroid treated rheumatoid arthritis', Bone, vol. 15, pp. 452 - 452, http://dx.doi.org/10.1016/8756-3282(94)90837-0
    Journal articles | 1994
    Professor Peter Ian Croucher
    Compston JE; Croucher PI; Garrahan NJ; Yamaguchi K; Lindsay P; Shaw R, 1994, 'O4. Effect of gonadotrophin-releasing hormone analogues on bone structure', Bone, vol. 15, pp. 450 - 450, http://dx.doi.org/10.1016/8756-3282(94)90827-3
    Journal articles | 1994
    Professor Peter Ian Croucher
    Compston JE; Croucher PI; Garrahan NJ; Yamaguchi R, 1994, 'P54. Quantitative analysis of iliac crest trabecular bone structure in primary osteoporosis', Bone, vol. 15, pp. 243 - 243, http://dx.doi.org/10.1016/8756-3282(94)90787-0
    Journal articles | 1994
    Professor Peter Ian Croucher
    Croucher PI; Vedi S; Motley RJ; Garrahan NJ; Stanton MR; Compston JE, 1994, 'P17. Reduced bone formation in patients with osteoporosis associated with inflammatory bowel disease', Bone, vol. 15, pp. 121 - 121, http://dx.doi.org/10.1016/8756-3282(94)90940-7
    Journal articles | 1992
    Professor Peter Ian Croucher
    Meikle MC; Bord S; Hembry RM; Compston J; Croucher PI; Reynolds JJ, 1992, 'Human osteoblasts in culture synthesize collagenase and other matrix metalloproteinases in response to osteotropic hormones and cytokines', Journal of Cell Science, vol. 103, pp. 1093 - 1099
    Journal articles | 1992
    Professor Peter Ian Croucher
    Croucher PI; Wright CDP; Garrahan NJ; Kudlac H; Williams AJ; Compston JE, 1992, 'Characteristics of trabecular bone resorption cavities in patients with chronic renal failure', Bone and Mineral, vol. 16, pp. 139 - 147, http://dx.doi.org/10.1016/0169-6009(92)90884-G
    Journal articles | 1992
    Professor Peter Ian Croucher
    Garrahan NJ; Boyde A; Croucher PI; Radcliffe, R; Compston JE, 1992, 'Method for the validation of structural analysis of two-dimensional histological sections using computerised three-dimensional reconstruction', Bone, vol. 13, pp. A12 - A12, http://dx.doi.org/10.1016/8756-3282(92)90502-n
    Journal articles | 1992
    Professor Peter Ian Croucher
    Yamaguchi K; Croucher PI; Garrahan NJ; Compston JE, 1992, 'The distribution of individual osteoid seam and resorption cavity lengths in human trabecular iliac crest bone', Bone, vol. 13, pp. A38 - A38, http://dx.doi.org/10.1016/8756-3282(92)90609-z
    Journal articles | 1992
    Professor Peter Ian Croucher
    Bord S; Hembry RM; Compston J; Croucher PI; Reynolds JJ; Meikle MC, 1992, 'P3. Matrix melalloproteinases and TIMF expression by human osteoblasts in vitro: effect of parathyroid hormone and monocyte conditioned medium', Bone, vol. 13, pp. 276 - 276, http://dx.doi.org/10.1016/8756-3282(92)90222-i
    Journal articles | 1992
    Professor Peter Ian Croucher
    Croucher PI; Vedi S; Garrahan NJ; Compston JE, 1992, 'Resorption cavity characteristics in patients with primary and secondary osteoporosis', Bone and Mineral, vol. 17, pp. 174 - 174, http://dx.doi.org/10.1016/0169-6009(92)92034-n
    Journal articles | 1992
    Professor Peter Ian Croucher
    Compston JE; Croucher PI; RJ M; Vedi S; Garrahan NJ; Stanton MR, 1992, 'Reduced bone formation in patients with osteoporosis associated with inflammatory bowel disease', Bone, vol. 13, pp. A8 - A8, http://dx.doi.org/10.1016/8756-3282(92)90489-j
    Journal articles | 1992
    Professor Peter Ian Croucher
    Croucher PI; Garrahan NJ; Compston JE, 1992, 'P8. Reduced resorption cavity size in non-steroid treated patients with rheumatoid arthritis', Bone, vol. 13, pp. 109 - 109, http://dx.doi.org/10.1016/8756-3282(92)90411-o
    Journal articles | 1992
    Professor Peter Ian Croucher
    Compston IE; Garrahan NJ; Croucher PI; Wright CDP; Yamaguchi K, 1992, 'Quantitative analysis of trabecular bone structure: Studies in patients with osteoporosis and in women treated with antioestrogens', Bone, vol. 13, pp. A8 - A8, http://dx.doi.org/10.1016/8756-3282(92)90488-i
    Journal articles | 1992
    Professor Peter Ian Croucher
    Croucher PI; Laskey MA; Coxon A; Kreitzman S; Compston JE, 1992, 'P1. The effect of diet-induced weight loss on total body bone mass', Bone, vol. 13, pp. 275 - 275, http://dx.doi.org/10.1016/8756-3282(92)90220-q
    Journal articles | 1992
    Professor Peter Ian Croucher
    Compston JE; Croucher PI; Laskey MA; Coxon A; Kreitzman S, 1992, 'The effect of diet-induced weight loss on total body bone mass', Bone and Mineral, vol. 17, pp. 173 - 173, http://dx.doi.org/10.1016/0169-6009(92)92033-m
    Journal articles | 1992
    Professor Peter Ian Croucher
    Croucher PI; Garrahan NJ; Compston JE, 1992, 'Assessment of resorption cavity characteristics in trabecular bone: Changes in primary and secondary osteoporosis', Bone, vol. 13, pp. A9 - A9, http://dx.doi.org/10.1016/8756-3282(92)90490-n
    Journal articles | 1991
    Professor Peter Ian Croucher
    Compston JE; Vedi S; Croucher PI, 1991, 'Low prevalence of osteomalacia in elderly patients with hip fracture', Age and Ageing, vol. 20, pp. 132 - 134, http://dx.doi.org/10.1093/ageing/20.2.132
    Journal articles | 1991
    Professor Peter Ian Croucher
    Croucher PI; Garrahan NJ; Compston JE, 1991, '12. Resorption cavity characteristics in renal osteodystrophy', Bone, vol. 12, pp. 289 - 289, http://dx.doi.org/10.1016/8756-3282(91)90089-2
    Journal articles | 1991
    Professor Peter Ian Croucher
    Croucher PI; Laskey MA; Coxon A; Kreitzman S; Compston JE, 1991, 'The Effect of Diet-Induced Weight loss on Total Body Bone Mass', Clinical Science, vol. 81, pp. 16P - 16P, http://dx.doi.org/10.1042/cs081016pa
    Journal articles | 1990
    Professor Peter Ian Croucher
    Wright CDP; Crawley EO; Evans WD; Garrahan NJ; Mellish RWE; Croucher PI; Compston JE, 1990, 'The relationship between spinal trabecular bone mineral content and iliac crest trabecular bone volume', Calcified Tissue International, vol. 46, pp. 162 - 165, http://dx.doi.org/10.1007/BF02555037
    Journal articles | 1990
    Professor Peter Ian Croucher
    Garrahan NJ; Croucher PI; Compston JE, 1990, 'A computerised technique for the quantitative assessment of resorption cavities in trabecular bone', Bone, vol. 11, pp. 241 - 245, http://dx.doi.org/10.1016/8756-3282(90)90076-B
    Journal articles | 1990
    Professor Peter Ian Croucher
    Wright CD; Crawley EO; Evans WD; Garrahan NJ; Mellish RW; Croucher PI; Compston JE, 1990, 'The relationship between spinal trabecular bone mineral content and iliac crest trabecular bone volume.', Basic life sciences, vol. 55, pp. 79 - 82, http://dx.doi.org/10.1007/978-1-4613-1473-8_11
    Journal articles | 1989
    Professor Peter Ian Croucher
    COMPSTON JE; SILVER AC; CROUCHER PI; BROWN RC; WOODHEAD JS, 1989, 'ELEVATED SERUM INTACT PARATHYROID HORMONE LEVELS IN ELDERLY PATIENTS WITH HIP FRACTURE', Clinical Endocrinology, vol. 31, pp. 667 - 672, http://dx.doi.org/10.1111/j.1365-2265.1989.tb01291.x
    Journal articles | 1989
    Professor Peter Ian Croucher
    Compston JE; Mellish RWE; Croucher P; Newcombe R; Garrahan NJ, 1989, 'Structural mechanisms of trabecular bone loss in man', Bone and Mineral, vol. 6, pp. 339 - 350, http://dx.doi.org/10.1016/0169-6009(89)90039-1
    Journal articles | 1989
    Professor Peter Ian Croucher
    Croucher PI; Mellish RWE; Vedi S; Garrahan NJ; Compston JE, 1989, 'The relationship between resorption depth and mean interstitial bone thickness: Age-related changes in man', Calcified Tissue International, vol. 45, pp. 15 - 19, http://dx.doi.org/10.1007/BF02556655
    Journal articles | 1989
    Professor Peter Ian Croucher
    Compston JE; Vedi S; Mellish RWE; Croucher P; O'Sullivan MM, 1989, 'Reduced bone formation in non-steroid treated patients with rheumatoid arthritis', Annals of the Rheumatic Diseases, vol. 48, pp. 483 - 487, http://dx.doi.org/10.1136/ard.48.6.483
    Journal articles | 1989
    Professor Peter Ian Croucher
    Silver A; Compston JE; Croucher PI; Woodhead JS, 1989, '6. Elevated serum intact parathyroid hormone levels in elderly patients with hip fracture', Bone, vol. 10, pp. 472 - 473, http://dx.doi.org/10.1016/8756-3282(89)90086-0
    Journal articles | 1989
    Professor Peter Ian Croucher
    Wright CDP; Crawley EO; Evans WD; Garrahan NJ; Mellish RWE; Croucher PI; Compston JE, 1989, 'P8. The relationship between spinal trabecular bone mineral content and iliac crest trabecular bone volume', Bone, vol. 10, pp. 477 - 477, http://dx.doi.org/10.1016/8756-3282(89)90101-4
    Journal articles | 1989
    Professor Peter Ian Croucher
    Croucher PI; Vedi S; Mellish RWE; Garrahan NJ; Compston JE, 1989, 'P8. Resorption depth and mean interstitial bone thickness (MIBT): age-related changes in man', Bone, vol. 10, pp. 149 - 149, http://dx.doi.org/10.1016/8756-3282(89)90032-x
    Journal articles | 1989
    Professor Peter Ian Croucher
    Garrahan NJ; Croucher PI; Wright C; Compston JE, 1989, 'P9. A new computer technique for the measurement of resorption cavity depth in trabecular bone', Bone, vol. 10, pp. 149 - 150, http://dx.doi.org/10.1016/8756-3282(89)90033-1
    Journal articles | 1989
    Professor Peter Ian Croucher
    Vedi S; Croucher PI; O'Sullivan MM; Compston JE, 1989, '5. Reduced bone formation in non-steroid treated patients with rheumatoid arthritis', Bone, vol. 10, pp. 144 - 145, http://dx.doi.org/10.1016/8756-3282(89)90017-3
    Journal articles | 1989
    Professor Peter Ian Croucher
    Croucher P; Mellish RWE; Garrahan NJ; Compston JE, 1989, '7. Structural mechanisms of trabecular bone loss in primary and secondary osteoporosis', Bone, vol. 10, pp. 145 - 145, http://dx.doi.org/10.1016/8756-3282(89)90019-7
  • Conference Papers | 2021
    Professor Peter Ian Croucher
    Croucher P; Khoo WH; Chai R; Corr A; Smith J; Ren Q; Baldock P; McDonald M; Stewart S; Phan TG, 2021, 'Abstract IA015: Niche-dependent control of tumor cell dormancy', in Tumor Microenvironment Drives Tumor Cell Fate, American Association for Cancer Research, presented at Abstracts: AACR Virtual Special Conference: The Evolving Tumor Microenvironment in Cancer Progression: Mechanisms and Emerging Therapeutic Opportunities; in association with the Tumor Microenvironment (TME) Working Group; January 11-12, 2021, http://dx.doi.org/10.1158/1538-7445.tme21-ia015
    Conference Abstracts | 2020
    Professor Peter Ian Croucher
    Zhou S; Laurent L; Kemp JP; Forgetta V; Morris J; Pramatarova A; Croucher PI; Bassett J; Goltzman D; Evans DM; Richards J, 2020, 'Identifying targets for osteoporosis via whole exome sequencing and CRISPR-Cas9', in EUROPEAN JOURNAL OF HUMAN GENETICS, SPRINGERNATURE, Vol. 28, pp. 134 - 134, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000598482600243&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2020
    Professor Peter Ian Croucher
    Zhou S; Laurent L; Kemp J; Pramatarova A; Forgetta V; Morris J; Croucher P; Williams G; Bassett D; Goltzman D; Lotta L; Evans D; Richards B, 2020, 'Identifying Drug Targets via Whole Exome Sequencing and CRISPR-Cas9', in JOURNAL OF BONE AND MINERAL RESEARCH, WILEY, ELECTR NETWORK, Vol. 35, pp. 22 - 22, presented at Annual Meeting of the American-Society-for-Bone-and Mineral Research (ASBMR), ELECTR NETWORK, 11 September 2020 - 15 September 2020, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000593119300060&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2019
    Professor Peter Ian Croucher
    Beck-Cormier S; Lelliott CJ; Logan JG; Lafont DT; Merametdjian L; Leitch VD; Butterfield NC; Protheroe HJ; Croucher PI; Baldock PA; Gaultier-Lintia A; Maugars Y; Nicolas G; Banse C; Normant S; Magne N; Gérardin E; Bon N; Sourice S; Guicheux J; Beck L; Williams GR; Bassett JHD, 2019, 'Slc20a2, Encoding the Phosphate Transporter PiT2, Is an Important Genetic Determinant of Bone Quality and Strength', in Journal of Bone and Mineral Research, WILEY, Montreal, CANADA, pp. 1101 - 1114, presented at Annual Meeting of the American-Society-for-Bone-and-Mineral-Research, Montreal, CANADA, 28 September 2018 - 01 October 2018, http://dx.doi.org/10.1002/jbmr.3691
    Conference Papers | 2019
    Professor Peter Ian Croucher
    Opperman K; Vandyke K; Psaltis P; Croucher P; Noll J; Zannettino A, 2019, 'Macrophages as a potential therapeutic target: Clodronate-liposome treatment inhibits multiple myeloma tumour establishment in vivo', in CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, CIG MEDIA GROUP, LP, pp. E96 - E96, http://dx.doi.org/10.1016/j.clml.2019.09.156
    Conference Papers | 2018
    Professor Peter Ian Croucher
    Morris J; Kemp J; Youlten S; Logan J; Chai R; Vulpescu N; Forgetta V; Kleinman A; Mohanty S; Sergio M; Medina-Gomez C; Trajanoska K; Quinn J; Ghirardello E; Butterfield N; Curry K; Leitch V; Sparkes P; Laurent L; Adoum A-T; Mannan N; Komla-Ebri D; Pollard A; Dewhurst H; Kaptoge S; Baldock P; Cooper C; Reeve J; Ntzani E; Evangelou E; Ohlsson C; Karasik D; Rivadeneira F; Ackert-Bicknell C; Kiel D; Tobias J; Gregson C; Harvey N; Adams D; Lelliott C; Hinds D; Hsu Y-H; Maurano M; Croucher P; Williams G; Bassett D; Evans D; Richards B, 2018, 'An Atlas of Human and Murine Genetic Influences on Osteoporosis', in JOURNAL OF BONE AND MINERAL RESEARCH, WILEY, Montreal, CANADA, pp. 105 - 105, presented at Annual Meeting of the American-Society-for-Bone-and-Mineral-Research, Montreal, CANADA, 28 September 2018 - 01 October 2018, http://dx.doi.org/10.1002/jbmr.3621
    Conference Abstracts | 2017
    Professor Peter Ian Croucher
    Eisman J; Croucher P; Baldock P; Nguyen T; Brink R; Hesselson D; Nguyen S; Moni M; Youlten S, 2017, 'Identification of anabolic bone genes using whole genome sequencing in high bone mass families.', in JOURNAL OF BONE AND MINERAL RESEARCH, WILEY, WILEY 111 RIVER ST, HOBOKEN 07030-5774, NJ USA, Vol. 32, pp. S71 - S71, presented at Annual Meeting of the American-Society-for-Bone-and-Mineral-Research (ASBMR), WILEY 111 RIVER ST, HOBOKEN 07030-5774, NJ USA, 08 September 2017 - 11 September 2017, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000418869201011&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
    Conference Abstracts | 2017
    Professor Peter Ian Croucher
    Youlten S; Baldock P; Leitch V; Quinn J; Bartonicek N; Chai R; Eisman J; Bassett JHD; Williams G; Croucher P, 2017, 'Osteocytes express a unique transcriptome that underpins skeletal homeostasis.', in JOURNAL OF BONE AND MINERAL RESEARCH, WILEY, Denver, CO, Vol. 32, pp. S55 - S56, presented at Annual Meeting of the American-Society-for-Bone-and-Mineral-Research (ASBMR), Denver, CO, 08 September 2017 - 11 September 2017, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000418869200166&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2017
    Professor Peter Ian Croucher
    McDonald M; Ng PY; Butt D; Pathmanandavel K; Biro M; Terry R; Khoo WH; Mohanty S; Simic M; Chai R; Quinn J; Pettitt J; Abi-Hanna D; Jain R; Weninger W; Baldock P; Rogers M; Brink R; Pavlos N; Croucher P; Phan T, 2017, 'Intravital imaging of osteoclasts in vivo reveals cellular recycling as a novel cell fate mechanism.', in JOURNAL OF BONE AND MINERAL RESEARCH, WILEY, Denver, CO, Vol. 32, pp. S37 - S37, presented at Annual Meeting of the American-Society-for-Bone-and-Mineral-Research (ASBMR), Denver, CO, 08 September 2017 - 11 September 2017, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000418869200110&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2017
    Professor Peter Ian Croucher
    Gregson C; Newell F; Leo P; Paternoster L; Marshall M; Clark G; Morris J; Ge B; Bao X; Bassett D; Williams G; Youlten S; Croucher P; Smith GD; Evans D; Kemp J; Brown M; Tobias J; Duncan E, 2017, 'Genome-wide association study of extreme high bone mass identifies NPR3 as a novel BMD-associated gene and highlights the contribution of common genetic variation to extreme BMD phenotypes.', in JOURNAL OF BONE AND MINERAL RESEARCH, WILEY, Denver, CO, Vol. 32, pp. S207 - S207, presented at Annual Meeting of the American-Society-for-Bone-and-Mineral-Research (ASBMR), Denver, CO, 08 September 2017 - 11 September 2017, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000418869202136&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2016
    Professor Peter Ian Croucher
    McDonald M; Butt D; Terry R; Quinn J; Rogers M; Brink R; Croucher P; Phan T, 2016, 'Real-time intravital longitudinal imaging of osteoclast formation, function and fate during bone remodeling', in EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY-BLACKWELL, Melbourne, AUSTRALIA, Vol. 46, pp. 270 - 270, presented at International Congress of Immunology (ICI), Melbourne, AUSTRALIA, 21 August 2016 - 26 August 2016, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000383610400545&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2016
    Professor Peter Ian Croucher
    Byrne NM; Khoo WH; Mourad N; Quinn JAPJ; Shah S; Mcdonald MM; Cazet A; Swarbrick A; Phan TG; Rogers MJ; Croucher PI, 2016, 'Identification of dormant prostate cancer cells in the skeleton in vivo and ex vivo', in BJU INTERNATIONAL, WILEY-BLACKWELL, Melbourne, AUSTRALIA, Vol. 118, pp. 35 - 36, presented at 17th Asia-Pacific Prostate Cancer Conference, Melbourne, AUSTRALIA, 31 August 2016 - 03 September 2016, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000381708200082&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2015
    Professor Peter Ian Croucher
    Reagan MR; McDonald M; Terry R; Pettitt J; Le L; Mohanty S; Kneissel M; Kramer I; Brooks D; Bouxsein M; Rosen CJ; Ghobrial IM; Croucher P, 2015, 'Anti-Sclerostin Treatment Prevents Multiple Myeloma Induced Bone Loss and Reduces Tumor Burden', in BLOOD, AMER SOC HEMATOLOGY, Orlando, FL, Vol. 126, presented at 57th Annual Meeting of the American-Society-of-Hematology, Orlando, FL, 05 December 2015 - 08 December 2015, http://dx.doi.org/10.1182/blood.V126.23.119.119
    Conference Papers | 2014
    Professor Peter Ian Croucher
    Khor E-C; Fanashawe B; Qi Y; Croucher P; Herzog H; Baldock P, 2014, 'SNORD116, a Non-translated, Imprinted Central Regulator of Bone Mass: Possible Role in Skeletal Abnormalities in Prader-Willi Syndrome.', in JOURNAL OF BONE AND MINERAL RESEARCH, WILEY-BLACKWELL, Houston, TX, pp. S72 - S72, presented at Annual Meeting of the American-Society-for-Bone-and-Mineral-Research, Houston, TX, 12 September 2014 - 15 September 2014, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000356598700214&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2012
    Professor Peter Ian Croucher
    Holen I; Wang N; Reeves KJ; Fowles AM; Croucher PI; Eaton CL; Ottewell PD, 2012, 'Abstract PD07-08: Zoledronic acid specifically inhibits development of bone metastases in the post-menopausal setting – evidence from an in vivo breast cancer model', in Poster Discussion Abstracts, American Association for Cancer Research, presented at Abstracts: Thirty-Fifth Annual CTRC‐AACR San Antonio Breast Cancer Symposium‐‐ Dec 4‐8, 2012; San Antonio, TX, http://dx.doi.org/10.1158/0008-5472.sabcs12-pd07-08
    Conference Papers | 2003
    Professor Peter Ian Croucher
    Croucher PI; Shipman CM; Van Camp B; Vanderkerken K, 2003, 'Bisphosphonates and osteoprotegerin as inhibitors of myeloma bone disease', in Cancer, pp. 818 - 824, http://dx.doi.org/10.1002/cncr.11125
    Conference Papers | 2000
    Professor Peter Ian Croucher
    Shipman CM; Rogers MJ; Vanderkerken K; Van Camp B; Russell RGG; Croucher PI, 2000, 'Bisphosphonates: Mechanisms of action in multiple myeloma', in Acta Oncologica, pp. 829 - 835, http://dx.doi.org/10.1080/028418600750063587
    Conference Papers | 1999
    Professor Peter Ian Croucher
    Russell RGG; Rogers MJ; Frith JC; Luckman SP; Coxon FP; Benford HL; Croucher PI; Shipman C; Fleisch HA, 1999, 'The pharmacology of bisphosphonates and new insights into their mechanisms of action', in Journal of Bone and Mineral Research, pp. 53 - 65, http://dx.doi.org/10.1002/jbmr.5650140212
    Conference Papers | 1999
    Professor Peter Ian Croucher
    Russell RGG; Croucher PI; Rogers MJ, 1999, 'Bisphosphonates: Pharmacology, mechanisms of action and clinical uses', in Osteoporosis International, http://dx.doi.org/10.1007/PL00004164
    Conference Papers | 1999
    Professor Peter Ian Croucher
    Croucher PI; Wang F; Hargreaves PG, 1999, 'Interleukin-6 receptor shedding: A possible role for members of the ADAM family', in Biochemical Society Transactions, pp. 224 - 228, http://dx.doi.org/10.1042/bst0270224

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