Dr Ramon Martinez Marmol

Dr Ramon Martinez Marmol

Senior Lecturer
  • Ph.D. Biochemistry, Molecular Biology and Biophysics (University of Barcelona, Spain). 
Medicine & Health
School of Biomedical Sciences

I am a Senior Lecturer, SpinalCure Fellow, Scientia Fellow, and Head of the NeuroRepair and Mechanisms of Disease Lab in the School of Biomedical Sciences at the University of New South Wales (UNSW), Sydney.

I grew up in a small village near Barcelona, in Catalonia, a region located in the eastern part of Spain. I completed my PhD in Biochemistry, Molecular Biology and Biophysics at the University of Barcelona. In 2015, I relocated with my family to Australia as a postdoctoral researcher at the Queensland Brain Institute, initially working in Prof. Frédéric Meunier’s lab, and later as a Research Fellow under the supervision of Prof. Massimo Hilliard. In 2025, I was appointed as Senior Lecturer at UNSW, where I started my independent laboratory.

At UNSW, my lab aims to develop new strategies for repairing damaged neurons and to understand the molecular mechanisms responsible for neurodegeneration associated with viral infections.

  • Book Chapters | 2021
    Small C; Martínez-Mármol R; Amor R; Meunier FA; Joensuu M, 2021, 'Combining Single Molecule Super-Resolution Imaging Techniques to Unravel the Nanoscale Organization of the Presynapse', in Methods in Molecular Biology, pp. 265 - 286, http://dx.doi.org/10.1007/978-1-0716-1044-2_18
    Book Chapters | 2020
    Joensuu M; Martínez-Mármol R; Mollazade M; Padmanabhan P; Meunier FA, 2020, 'Single-molecule imaging of recycling synaptic vesicles in live neurons', in Neuromethods, pp. 81 - 114, http://dx.doi.org/10.1007/978-1-0716-0532-5_5
  • Journal articles | 2025
    Donato A; Ritchie FK; Lu L; Wadia M; Martinez-Marmol R; Kaulich E; Sankorrakul K; Lu H; Coakley S; Coulson EJ; Hilliard MA, 2025, 'OSP-1 protects neurons from autophagic cell death induced by acute oxidative stress', Nature Communications, 16, http://dx.doi.org/10.1038/s41467-024-55105-0
    Journal articles | 2024
    Fath T; Sytnyk V; Martínez-Mármol R, 2024, '‘10th cell architecture in development and disease (CADD)’: Meeting report', Cytoskeleton, 81, pp. 264 - 265, http://dx.doi.org/10.1002/cm.21815
    Journal articles | 2024
    Gormal RS; Martinez-Marmol R; Brooks AJ; Meunier FA, 2024, 'Location, location, location: Protein kinase nanoclustering for optimised signalling output.', Elife, 13, http://dx.doi.org/10.7554/eLife.93902
    Journal articles | 2024
    Longfield SF; Gormal RS; Feller M; Parutto P; Reingruber J; Wallis TP; Joensuu M; Augustine GJ; Martínez-Mármol R; Holcman D; Meunier FA, 2024, 'Synapsin 2a tetramerisation selectively controls the presynaptic nanoscale organisation of reserve synaptic vesicles', Nature Communications, 15, http://dx.doi.org/10.1038/s41467-024-46256-1
    Journal articles | 2024
    Small C; Harper C; Jiang A; Kontaxi C; Pronot M; Yak N; Malapaka A; Davenport EC; Wallis TP; Gormal RS; Joensuu M; Martínez-Mármol R; Cousin MA; Meunier FA, 2024, 'SV2A controls the surface nanoclustering and endocytic recruitment of Syt1 during synaptic vesicle recycling', Journal of Neurochemistry, 168, pp. 3188 - 3208, http://dx.doi.org/10.1111/jnc.16186
    Journal articles | 2023
    Longfield SF; Mollazade M; Wallis TP; Gormal RS; Joensuu M; Wark JR; van Waardenberg AJ; Small C; Graham ME; Meunier FA; Martínez-Mármol R, 2023, 'Tau forms synaptic nano-biomolecular condensates controlling the dynamic clustering of recycling synaptic vesicles', Nature Communications, 14, http://dx.doi.org/10.1038/s41467-023-43130-4
    Journal articles | 2023
    Martínez-Mármol R; Chai YJ; Conroy JN; Khan Z; Hong SM; Kim SB; Gormal RS; Lee DH; Lee JK; Coulson EJ; Lee MK; Kim SY; Meunier FA, 2023, 'Hericerin derivatives activates a pan-neurotrophic pathway in central hippocampal neurons converging to ERK1/2 signaling enhancing spatial memory', Journal of Neurochemistry, 165, pp. 791 - 808, http://dx.doi.org/10.1111/jnc.15767
    Journal articles | 2023
    Martínez-Mármol R; Giordano-Santini R; Kaulich E; Cho AN; Przybyla M; Riyadh MA; Robinson E; Chew KY; Amor R; Meunier FA; Balistreri G; Short KR; Ke YD; Ittner LM; Hilliard MA, 2023, 'SARS-CoV-2 infection and viral fusogens cause neuronal and glial fusion that compromises neuronal activity', Science Advances, 9, http://dx.doi.org/10.1126/sciadv.adg2248
    Journal articles | 2023
    Martínez-Mármol R; Muhaisen A; Cotrufo T; Roselló-Busquets C; Ros O; Hernaiz-Llorens M; Pérez-Branguli F; Andrés RM; Parcerisas A; Pascual M; Ulloa F; Soriano E, 2023, 'Syntaxin-1 is necessary for UNC5A-C/Netrin-1-dependent macropinocytosis and chemorepulsion', Frontiers in Molecular Neuroscience, 16, http://dx.doi.org/10.3389/fnmol.2023.1253954
    Journal articles | 2023
    Martínez-Mármol R; Small C; Jiang A; Palliyaguru T; Wallis TP; Gormal RS; Sibarita JB; Götz J; Meunier FA, 2023, 'Fyn nanoclustering requires switching to an open conformation and is enhanced by FTLD-Tau biomolecular condensates', Molecular Psychiatry, 28, pp. 946 - 962, http://dx.doi.org/10.1038/s41380-022-01825-y
    Journal articles | 2021
    Hernaiz-Llorens M; Martínez-Mármol R; Roselló-Busquets C; Soriano E, 2021, 'One raft to guide them all, and in axon regeneration inhibit them', International Journal of Molecular Sciences, 22, http://dx.doi.org/10.3390/ijms22095009
    Journal articles | 2021
    Hernaiz-Llorens M; Roselló-Busquets C; Durisic N; Filip A; Ulloa F; Martínez-Mármol R; Soriano E, 2021, 'Growth cone repulsion to Netrin-1 depends on lipid raft microdomains enriched in UNC5 receptors', Cellular and Molecular Life Sciences, 78, pp. 2797 - 2820, http://dx.doi.org/10.1007/s00018-020-03663-z
    Journal articles | 2020
    Harper CB; Small C; Davenport EC; Low DW; Smillie KJ; Martínez-Mármol R; Meunier FA; Cousin MA, 2020, 'An epilepsy-associated SV2A mutation disrupts synaptotagmin-1 expression and activity-dependent trafficking', Journal of Neuroscience, 40, pp. 4586 - 4595, http://dx.doi.org/10.1523/JNEUROSCI.0210-20.2020
    Journal articles | 2020
    Roselló-Busquets C; Hernaiz-Llorens M; Soriano E; Martínez-Mármol R, 2020, 'Nystatin Regulates Axonal Extension and Regeneration by Modifying the Levels of Nitric Oxide', Frontiers in Molecular Neuroscience, 13, http://dx.doi.org/10.3389/fnmol.2020.00056
    Journal articles | 2019
    Martínez-Mármol R; Mohannak N; Qian L; Wang T; Gormal RS; Ruitenberg MJ; Vanhaesebroeck B; Coulson EJ; Meunier FA, 2019, 'p110δ PI3-kinase inhibition perturbs APP and TNFα trafficking, reduces plaque burden, dampens neuroinflammation, and prevents cognitive decline in an Alzheimer's disease mouse model', Journal of Neuroscience, 39, pp. 7976 - 7991, http://dx.doi.org/10.1523/JNEUROSCI.0674-19.2019
    Journal articles | 2019
    Padmanabhan P; Martínez-Mármol R; Xia D; Götz J; Meunier FA, 2019, 'Frontotemporal dementia mutant Tau promotes aberrant Fyn nanoclustering in hippocampal dendritic spines', Elife, 8, http://dx.doi.org/10.7554/eLife.45040.001
    Journal articles | 2019
    Padmanabhan P; Martínez-Mármol R; Xia D; Götz J; Meunier FA, 2019, 'Frontotemporal dementia mutant Tau promotes aberrant Fyn nanoclustering in hippocampal dendritic spines.', Elife, 8, http://dx.doi.org/10.7554/eLife.45040
    Journal articles | 2019
    Roselló-Busquets C; de la Oliva N; Martínez-Mármol R; Hernaiz-Llorens M; Pascual M; Muhaisen A; Navarro X; del Valle J; Soriano E, 2019, 'Cholesterol depletion regulates axonal growth and enhances central and peripheral nerve regeneration', Frontiers in Cellular Neuroscience, 13, http://dx.doi.org/10.3389/fncel.2019.00040
    Journal articles | 2018
    Martínez-Mármol R; Styrczewska K; Pérez-Verdaguer M; Vallejo-Gracia A; Comes N; Sorkin A; Felipe A, 2018, 'PKC Activation Induces Ubiquitination-Dependent KV1.3 Endocytosis Mediated by Nedd4-2 Ubiquitin Ligase', Biophysical Journal, 114, pp. 301a - 301a, http://dx.doi.org/10.1016/j.bpj.2017.11.1713
    Journal articles | 2018
    Polanco JC; Li C; Bodea LG; Martinez-Marmol R; Meunier FA; Götz J, 2018, 'Amyloid-β and tau complexity - Towards improved biomarkers and targeted therapies', Nature Reviews Neurology, 14, pp. 22 - 40, http://dx.doi.org/10.1038/nrneurol.2017.162
    Journal articles | 2018
    Ros O; Barrecheguren PJ; Cotrufo T; Schaettin M; Roselló-Busquets C; Vílchez-Acosta A; Hernaiz-Llorens M; Martínez-Marmol R; Ulloa F; Stoeckli ET; Araújo SJ; Soriano E, 2018, 'A conserved role for Syntaxin-1 in pre- and post-commissural midline axonal guidance in fly, chick, and mouse', Plos Genetics, 14, http://dx.doi.org/10.1371/journal.pgen.1007432
    Journal articles | 2017
    Joensuu M; Martínez-Mármol R; Padmanabhan P; Glass NR; Durisic N; Pelekanos M; Mollazade M; Balistreri G; Amor R; Cooper-White JJ; Goodhill GJ; Meunier FA, 2017, 'Visualizing endocytic recycling and trafficking in live neurons by subdiffractional tracking of internalized molecules', Nature Protocols, 12, pp. 2590 - 2622, http://dx.doi.org/10.1038/nprot.2017.116
    Journal articles | 2017
    Martínez-Mármol R; Styrczewska K; Pérez-Verdaguer M; Vallejo-Gracia A; Comes N; Sorkin A; Felipe A, 2017, 'Ubiquitination mediates Kv1.3 endocytosis as a mechanism for protein kinase C-dependent modulation', Scientific Reports, 7, http://dx.doi.org/10.1038/srep42395
    Journal articles | 2017
    Pérez-Verdaguer M; Capera J; Martínez-Mármol R; Camps M; Comes N; Tamkun MM; Felipe A, 2017, 'Deciphering the Kv1.3/Caveolin Interaction', Biophysical Journal, 112, pp. 252a - 252a, http://dx.doi.org/10.1016/j.bpj.2016.11.1375
    Journal articles | 2017
    Roig SR; Solé L; Vallejo-Gracia A; Sastre D; Serrano-Albarrás A; Serrano-Novillo C; Martínez-Mármol R; Tamkun MM; Felipe A, 2017, 'The C-Terminal Domain of Kv1.3 Interacts with KCNE4 to form Oligomeric Channels', Biophysical Journal, 112, pp. 545a - 545a, http://dx.doi.org/10.1016/j.bpj.2016.11.2944
    Journal articles | 2017
    Styrczewska K; Martínez-Mármol R; Comes N; Estadella I; Pérez-Verdaguer M; Pujadas L; Soriano E; Sorkin A; Felipe A, 2017, 'ERK1/2 Mediates EGF-Dependent Kv1.3 Endocytosis', Biophysical Journal, 112, pp. 251a - 252a, http://dx.doi.org/10.1016/j.bpj.2016.11.1374
    Journal articles | 2016
    Martínez-Mármol R; Barneda-Zahonero B; Soto D; Andrés RM; Coccia E; Gasull X; Planells-Ferrer L; Moubarak RS; Soriano E; Comella JX, 2016, 'FAIM-L regulation of XIAP degradation modulates Synaptic Long-Term Depression and Axon Degeneration', Scientific Reports, 6, http://dx.doi.org/10.1038/srep35775
    Journal articles | 2016
    Martínez-Mármol R; Comes N; Styrczewska K; Pérez-Verdaguer M; Vicente R; Pujadas L; Soriano E; Sorkin A; Felipe A, 2016, 'Unconventional EGF-induced ERK1/2-mediated Kv1.3 endocytosis', Cellular and Molecular Life Sciences, 73, pp. 1515 - 1528, http://dx.doi.org/10.1007/s00018-015-2082-0
    Journal articles | 2016
    Pérez-Verdaguer M; Capera J; Martínez-Mármol R; Camps M; Comes N; Tamkun MM; Felipe A, 2016, 'Caveolin interaction governs Kv1.3 lipid raft targeting', Scientific Reports, 6, http://dx.doi.org/10.1038/srep22453
    Journal articles | 2016
    Solé L; Roig SR; Vallejo-Gracia A; Serrano-Albarrás A; Martínez-Mármol R; Tamkun MM; Felipe A, 2016, 'The C-terminal domain of Kv1.3 regulates functional interactions with the KCNE4 subunit', Journal of Cell Science, 129, pp. 4265 - 4277, http://dx.doi.org/10.1242/jcs.191650
    Journal articles | 2016
    Wang T; Martin S; Nguyen TH; Harper CB; Gormal RS; Martinez-Marmol R; Karunanithi S; Coulson EJ; Glass NR; Cooper-White JJ; van Swinderen B; Meunier FA, 2016, 'Flux of signalling endosomes undergoing axonal retrograde transport is encoded by presynaptic activity and TrkB (vol 7, 12976, 2016)', NATURE COMMUNICATIONS, 7, http://dx.doi.org/10.1038/ncomms13768
    Journal articles | 2016
    Wang T; Martin S; Nguyen TH; Harper CB; Gormal RS; Martínez-Mármol R; Karunanithi S; Coulson EJ; Glass NR; Cooper-White JJ; Van Swinderen B; Meunier FA, 2016, 'Flux of signalling endosomes undergoing axonal retrograde transport is encoded by presynaptic activity and TrkB', Nature Communications, 7, http://dx.doi.org/10.1038/ncomms12976
    Journal articles | 2015
    Ros O; Cotrufo T; Martínez-Mármol R; Soriano E, 2015, 'Regulation of patterned dynamics of local exocytosis in growth cones by Netrin-1', Journal of Neuroscience, 35, pp. 5156 - 5170, http://dx.doi.org/10.1523/JNEUROSCI.0124-14.2015
    Journal articles | 2015
    Ulloa F; Gonzàlez-Juncà A; Meffre D; Barrecheguren PJ; Martínez-Mármol R; Pazos I; Olivé N; Cotrufo T; Seoane J; Soriano E, 2015, 'Blockade of the SNARE protein syntaxin 1 inhibits glioblastoma tumor growth', Plos One, 10, http://dx.doi.org/10.1371/journal.pone.0119707
    Journal articles | 2014
    Martínez-Mármol R; Pérez-Verdaguer M; Roig SR; Vallejo-Gracia A; Gotsi P; Serrano-Albarrás A; Bahamonde MI; Ferrer-Montiel A; Fernández-Ballester G; Comes N; Felipe A, 2014, 'A Non-Canonical Di-Acidic Signal at the C-Terminal of KV1.3 Determines Anterograde Trafficking and Surface Expression', Biophysical Journal, 106, pp. 739a - 739a, http://dx.doi.org/10.1016/j.bpj.2013.11.4072
    Journal articles | 2013
    Cotrufo T; Andrés RM; Ros O; Pérez‐Brangulí F; Muhaisen A; Fuschini G; Martínez R; Pascual M; Comella JX; Soriano E, 2013, 'Syntaxin 1 is required for DCC / N etrin‐1‐dependent chemoattraction of migrating neurons from the lower rhombic lip', European Journal of Neuroscience, 38, pp. 2338 - 2338, http://dx.doi.org/10.1111/ejn.12312
    Journal articles | 2013
    Marti'nez-Mármol R; Pérez-Verdaguer M; Roig SR; Vallejo-Gracia A; Gotsi P; Serrano-Albarrás A; Bahamonde MI; Ferrer-Montiel A; Fernández-Ballester G; Comes N; Felipe A, 2013, 'A non-canonical di-acidic signal at the C-terminus of Kv1.3 determines anterograde trafficking and surface expression', Journal of Cell Science, 126, pp. 5681 - 5691, http://dx.doi.org/10.1242/jcs.134825
    Journal articles | 2012
    Cotrufo T; Andrés RM; Ros O; Pérez-Brangulí F; Muhaisen A; Fuschini G; Martínez R; Pascual M; Comella JX; Soriano E, 2012, 'Syntaxin 1 is required for DCC/Netrin-1-dependent chemoattraction of migrating neurons from the lower rhombic lip', European Journal of Neuroscience, 36, pp. 3152 - 3164, http://dx.doi.org/10.1111/j.1460-9568.2012.08259.x
    Journal articles | 2012
    David M; Macías A; Moreno C; Prieto A; Martínez-Mármol R; Vicente R; González T; Felipe A; Tamkun MM; Valenzuela C, 2012, 'Protein kinase C (PKC) activity regulates functional effects of K vβ1.3 subunit on K V1.5 channels: Identification of a cardiac K v1.5 channelosome', Journal of Biological Chemistry, 287, pp. 21416 - 21428, http://dx.doi.org/10.1074/jbc.M111.328278
    Journal articles | 2009
    David M; Martinez-Marmol R; Gonzalez T; Felipe A; Valenzuela C, 2009, 'Differential Regulation Of Navß Subunits During Myogenesis', Biophysical Journal, 96, pp. 250a - 251a, http://dx.doi.org/10.1016/j.bpj.2008.12.1233
    Journal articles | 2009
    Villalonga N; Martínez-Mármol R; Solè L; Vicente R; Soler C; Tamkun MM; Felipe A, 2009, 'Partnership interactions target Kv1.5 to distinct membrane surface microdomains', Biophysical Journal, 96, pp. 176a - 176a, http://dx.doi.org/10.1016/j.bpj.2008.12.820
    Journal articles | 2008
    David M; Martínez-Mármol R; Gonzalez T; Felipe A; Valenzuela C, 2008, 'Differential regulation of Navβ subunits during myogenesis', Biochemical and Biophysical Research Communications, 368, pp. 761 - 766, http://dx.doi.org/10.1016/j.bbrc.2008.01.138
    Journal articles | 2008
    Martínez-Mármol R; Roura-Ferrer M; Felipe A, 2008, 'Targeting potassium channels: New advances in cardiovascular therapy', Recent Patents on Cardiovascular Drug Discovery, 3, pp. 105 - 118, http://dx.doi.org/10.2174/157489008784705386
    Journal articles | 2008
    Martínez-Mármol R; Villalonga N; Solé L; Vicente R; Tamkun MM; Soler C; Felipe A, 2008, 'Multiple Kv1.5 targeting to membrane surface microdomains', Journal of Cellular Physiology, 217, pp. 667 - 673, http://dx.doi.org/10.1002/jcp.21538
    Journal articles | 2008
    Roura-Ferrer M; Solé L; Martínez-Mármol R; Villalonga N; Felipe A, 2008, 'Skeletal muscle Kv7 (KCNQ) channels in myoblast differentiation and proliferation', Biochemical and Biophysical Research Communications, 369, pp. 1094 - 1097, http://dx.doi.org/10.1016/j.bbrc.2008.02.152
    Journal articles | 2008
    Villalonga N; Martínez-Mármol R; Roura-Ferrer M; David M; Valenzuela C; Soler C; Felipe A, 2008, 'Cell cycle-dependent expression of Kv1.5 is involved in myoblast proliferation', Biochimica Et Biophysica Acta Molecular Cell Research, 1783, pp. 728 - 736, http://dx.doi.org/10.1016/j.bbamcr.2008.01.001
    Journal articles | 2007
    Martínez-Mármol R; David M; Sanches R; Roura-Ferrer M; Villalonga N; Sorianello E; Webb SM; Zorzano A; Gumà A; Valenzuela C; Felipe A, 2007, 'Voltage-dependent Na+ channel phenotype changes in myoblasts. Consequences for cardiac repair', Cardiovascular Research, 76, pp. 430 - 441, http://dx.doi.org/10.1016/j.cardiores.2007.08.009
    Journal articles | 2006
    Felipe A; Vicente R; Villalonga N; Roura-Ferrer M; Martínez-Mármol R; Solé L; Ferreres JC; Condom E, 2006, 'Potassium channels: New targets in cancer therapy', Cancer Detection and Prevention, 30, pp. 375 - 385, http://dx.doi.org/10.1016/j.cdp.2006.06.002
  • Preprints | 2023
    Gormal R; Martínez-Mármol R; Brooks A; Meunier F, 2023, Location, Location, Location: Protein kinase nanoclustering for optimized signalling output, http://dx.doi.org/10.1101/2023.09.29.560079
    Preprints | 2023
    Jiang A; Gormal RS; Kasula R; Blum A; Salla-Martret M; Chai YJ; Wallis TP; Brouillet JZ; Padmanabhan P; Weeratunga S; Livingstone EK; Mollazade M; Joensuu M; Martínez-Mármol R; Collins BM; Meunier FA, 2023, VAMP2/Munc18-1 domain 3a interaction controls the nanoscale reorganization underpinning vesicular priming, http://dx.doi.org/10.1101/2023.09.10.556776
    Preprints | 2023
    Sanders S; Gormal R; Wallis T; Joensuu M; Augustine G; Martinez-Marmol R; Meunier F, 2023, Synapsin2a tetramerization selectively controls the presynaptic nanoscale organisation of reserve synaptic vesicles., http://dx.doi.org/10.21203/rs.3.rs-2722570/v1
    Conference Papers | 2023
    Sanders SF; Mollazade M; Wallis TP; Gormal RS; Joensuu M; Wark JR; Waardenberg AJ; Small C; Graham ME; Martinez-Marmol R; Meunier FA, 2023, 'Tau - A master regulator of recycling synaptic vesicle clustering at the presynapse', in JOURNAL OF NEUROCHEMISTRY, WILEY, pp. 142 - 142
    Preprints | 2022
    Small C; Harper C; Jiang A; Kontaxi C; Yak N; Malapaka A; Davenport EC; Wallis TP; Gormal RS; Joensuu M; Martínez-Mármol R; Cousin MA; Meunier FA, 2022, Surface SV2A-Syt1 nanoclusters act as a sequestration hub that limits dynamin-1 recruitment and targeting to recycling synaptic vesicles, http://dx.doi.org/10.1101/2022.12.12.520075
    Preprints | 2021
    Martinez-Marmol R; Giordano-Santini R; Kaulich E; Cho A-N; Riyadh MA; Robinson E; Balistreri G; Meunier FA; Ke YD; Ittner LM; Hilliard MA, 2021, The SARS-CoV-2 spike (S) and the orthoreovirus p15 cause neuronal and glial fusion, http://dx.doi.org/10.1101/2021.09.01.458544
    Preprints | 2021
    Martínez-Mármol R; Muhaisen A; Cotrufo T; Roselló-Busquets C; Hernaiz-Llorens M; Pérez-Branguli F; Andrés RM; Ros O; Pascual M; Ulloa F; Soriano E, 2021, Syntaxin-1 is necessary for UNC5/Netrin-1-dependent macropinocytosis and chemorepulsion, http://dx.doi.org/10.1101/2021.05.20.444954
    Preprints | 2021
    Small C; Harper C; Kontaxi C; Davenport E; Wallis T; Malapaka A; Yak N; Joensuu M; Martínez-Mármol R; Cousin MA; Meunier FA, 2021, SV2A-Syt1 interaction controls surface nanoclustering and access to recycling synaptic vesicles, http://dx.doi.org/10.1101/2021.12.08.471864
    Preprints | 2020
    Martínez-Mármol R; Chai Y; Khan Z; Kim SB; Hong SM; Gormal R; Lee DH; Lee JK; Lee MK; Kim SY; Meunier F, 2020, Hericerin derivatives fromHericium erinaceusexert BDNF-like neurotrophic activity in central hippocampal neurons and enhance memory, http://dx.doi.org/10.1101/2020.08.28.271676
    Preprints | 2020
    Small C; Martínez-Mármol R; Wallis T; Gormal R; Götz J; Meunier F, 2020, Frontotemporal dementia mutant tau (P301L) locks Fyn in an open, active conformation conducive to nanoclustering, http://dx.doi.org/10.1101/2020.09.04.282855
    Preprints |
    Kasula R; Blum A; Salla-Martret ME; Chai YJ; Jiang A; Wallis TP; Gormal RS; Brouillet JZ; Padmanabhan P; Weeratunga SK; Livingstone EK; Mollazade M; Joensuu M; Martí nez-Má rmol RON; Collins BM; Meunier F, VAMP2 Binding to Munc18-1 Domain 3a Controls the Nanoscale Reorganization of the Plasma Membrane and Vesicle Interface During Vesicular Priming, http://dx.doi.org/10.2139/ssrn.3362260

  • 2025-2028. NHMRC Ideas Grant (#2038899): Viral-induced neuronal fusion: Uncovering a new cause of neurological dysfunction. CIA Dr Martínez-Mármol. $890,000 AUD.

 

  • 2025-2030:  I-Peter Farrell Spinal Cure Fellowship: Fusion of Axons Innovative THerapy (FAITH): Using fusogens to repair injured nerves. CIA Dr Martínez-Mármol. $1,500,000 AUD.
  • 2022-2024:  UQ Research Stimulus Fellowship. University of Queensland, Australia. $180,000 AUD.
  • 2017-2019:  CJCADR Postdoctoral Fellowship. Clem Jones Centre for Ageing Dementia Research (CJCADR), Australia. $164,000 AUD.
  • 2012-2014:  Juan de la Cierva Postdoctoral Junior Fellowship. Spanish Ministry of Science and Innovation, Spain. $110,400 EUR.
  • 2005-2008:  Predoctoral Training Fellowship. Training Program for Academic Staff (Formacion de Personal Universitario – FPU). Spanish Ministry of Education and Science, Spain. $104,000 EUR.

My research focuses on understanding how the activity of signalling complexes is modulated following spinal cord injury and in neurodegenerative diseases such as Alzheimer’s disease. I am also interested in studying how viral infections influence the initiation and progression of neurodegenerative disorders, with particular emphasis on their chronic effects on the spread of toxic protein aggregates throughout the brain. Ultimately, my goal is to develop innovative therapeutic strategies to repair damaged neurons and prevent their pathological degeneration.

My lab uses a powerful combination of human-derived stem cells, brain organoids, C. elegans, and mouse in vivo models, with advanced imaging and computational approaches. This integrative, multi-scale approach allows us to connect molecular events inside a single neuron to dysfunction observed across the nervous system. Using these tools, we have revealed new mechanisms linking viral infections to neurodegeneration, uncovered the role of single-protein dynamics in the progression of neurological diseases, and developed advanced screening platforms to identify candidate therapeutic molecules with potential for spinal cord repair and neuroprotection.

The quality and impact of my research are reflected by publications in leading scientific journals, including Science Advances, Molecular Psychiatry, Nature Protocols, Nature Communications, Nature Reviews Neurology, The Journal of Neuroscience, eLife, and Cardiovascular Research.

The NeuroRepair and Mechanisms of Disease Lab welcomes collaborations and is committed to training the next generation of scientists in neurobiology, advanced imaging, and translational neurotherapeutics. We welcome partnerships with academic groups, industry, community organisations, and philanthropic supporters who share our passion and vision of advancing fundamental knowledge to develop treatments that meaningfully improve the lives of people living with neurological injury and disease.

 

My Research Supervision

  • Kimaya Gadre (BSc, Hons), PhD Student. 2025- ongoing, co-supervision with Prof. Massimo Hilliard, University of Queensland, Brisbane, Australia.

My Teaching

I have over 15 years of research experience across multiple disciplines related to cell and molecular biology and biophysics, with a particular expertise in ion channels’ biology, protein trafficking and aggregation, synaptic transmission, dementia disorders, neuroinflammation and viral infections.  This experience provided me with comprehensive practical knowledge of various techniques, including molecular biology, super-resolution imaging and behavioural neuroscience.  Beyond teaching and supervising research students, I have also created and delivered undergraduate course materials to small groups and large classes in universities from two countries: the University of Barcelona (Spain) and the University of Queensland (Australia).  Notably, I have conducted these classes in three languages (Spanish, Catalan, and English), allowing me to participate in a diverse learning environment, adapting my teaching methods to different linguistic and cultural backgrounds.

During my early career at the University of Barcelona, I gained substantial teaching experience through two nationally competitive fellowships that supported my development as a university educator. I taught and coordinated courses in biochemistry, molecular biology, cell biology, and neurobiology, integrating research-based case studies and interactive learning to strengthen students’ practical and critical-thinking skills. Since relocating to Australia, I have contributed to teaching across several departments, including adapting neuroscience practicals to fully online delivery during the COVID-19 lockdown. This experience expanded my expertise in hybrid, digital, and research-informed teaching. I have also served as a reviewer for biotechnology postgraduate assessments and chaired PhD thesis examinations. Across these roles, I have built strong communication and mentoring skills, supporting students from diverse backgrounds and engaging broader communities through public talks and outreach activities.