Professor Richard John Epstein
Adjunct Professor

Professor Richard John Epstein

MBBS (Syd)

MBA (Dur)

MD (Lond)

PhD (Cantab)

FRACP

FRCP (Lond)

medicine-health
St Vincent's Clinical School

I am a Visiting Scientist in the Garvan Institute of Medical Research where my research centres on the molecular evolution of human cancers, and a Conjoint Professor of the UNSW Clinical School, St Vincent's Hospital.

In my clinical work, since 2018 I have been the Medical Director and Department Chair of Oncology, New Hope Cancer Centre, Beijing United Hospital, China.  We have a close working relationship with Peking University Cancer Hospital, and are GCP-accredited for recruiting patient to clinical trials. 

Before returning in 2009 to Sydney, where I helped to set up The Kinghorn Cancer Centre, I had helped to set up major new Cancer Centres in Singapore and The University of Hong Kong.

In 1996 I patented the invention of phosphorylation-state-specific antibodies, which invention has since earned approximately US$20m royalties for Harvard University and Dana-Farber Cancer Institute, and led to development of a number of successful diagnostic reagent companies.

 

 

Publications

  • Book Chapters | 2006
    Professor Richard John Epstein
    Epstein RJ; Todd D, 2006, 'Professionalism', in Problem-Based Medical Case Management, pp. 271 - 279
    Books | 2003
    Professor Richard John Epstein
    Epstein R, 2003, medicine for examinations
    Books | 2003
    Professor Richard John Epstein
    Epstein RJ, 2003, Human Molecular Biology An Introduction to the Molecular Basis of Health and Disease, Cambridge University Press
  • Journal articles | 2021
    Professor Richard John Epstein
    Epstein RJ; Tian LJ; Gu YF, 2021, '2b or Not 2b: How Opposing FGF Receptor Splice Variants Are Blocking Progress in Precision Oncology', Journal of Oncology, vol. 2021, pp. 9955456, http://dx.doi.org/10.1155/2021/9955456
    Journal articles | 2020
    Professor Richard John Epstein
    Lami H; Epstein RJ; Cherepanoff S; Conway RM, 2020, 'Effective conservative management of locally advanced conjunctival melanoma using initial systemic therapy', Clinical and Experimental Ophthalmology, vol. 48, pp. 402 - 404, http://dx.doi.org/10.1111/ceo.13691
    Journal articles | 2020
    Professor Richard John Epstein
    Sternberg CN; Saad F; Graff JN; Peer A; Vaishampayan UN; Leung E; Rosenbaum E; Gurney H; Epstein RJ; Davis ID; Wu B; Trandafir L; Wagner VJ; Hussain M, 2020, 'A randomised phase II trial of three dosing regimens of radium-223 in patients with bone metastatic castration-resistant prostate cancer', Annals of Oncology, vol. 31, pp. 257 - 265, http://dx.doi.org/10.1016/j.annonc.2019.10.025
    Journal articles | 2019
    Professor Richard John Epstein
    Vasista A; Stockler M; Martin A; Pavlakis N; Sjoquist K; Goldstein D; Gill S; Jain V; Liu G; Kannourakis G; Kim YH; Nott L; Snow S; Burge M; Harris D; Jonker D; Chua YJ; Epstein R; Bonaventura A; Kiely B, 2019, 'Accuracy and Prognostic Significance of Oncologists’ Estimates and Scenarios for Survival Time in Advanced Gastric Cancer', Oncologist, vol. 24, pp. e1102 - e1107, http://dx.doi.org/10.1634/theoncologist.2018-0613
    Journal articles | 2019
    Professor Richard John Epstein
    Lin FP-Y; Jameson MB; Epstein RJ, 2019, 'Predicting survival in advanced cancers by applying machine learning to clinical narratives.', Journal of Global Oncology, vol. 5, pp. 32 - 32, http://dx.doi.org/10.1200/jgo.2019.5.suppl.32
    Journal articles | 2019
    Professor Richard John Epstein
    Emmett L; Crumbaker M; Ho B; Willowson K; Eu P; Ratnayake L; Epstein R; Blanksby A; Horvath L; Guminski A; Mahon K; Gedye C; Yin C; Stricker P; Joshua AM, 2019, 'Results of a Prospective Phase 2 Pilot Trial of 177 Lu–PSMA-617 Therapy for Metastatic Castration-Resistant Prostate Cancer Including Imaging Predictors of Treatment Response and Patterns of Progression', Clinical Genitourinary Cancer, vol. 17, pp. 15 - 22, http://dx.doi.org/10.1016/j.clgc.2018.09.014
    Journal articles | 2019
    Professor Richard John Epstein
    Emmett L; Yin C; Crumbaker M; Hruby G; Kneebone A; Epstein R; Nguyen Q; Hickey A; Ihsheish N; O'Neill G; Horvath L; Chalasani V; Stricker P; Joshua AM, 2019, 'Rapid modulation of PSMA expression by androgen deprivation: Serial 68Ga-PSMA-11 PET in men with hormone-sensitive and castrate-resistant prostate cancer commencing androgen blockade', Journal of Nuclear Medicine, vol. 60, pp. 950 - 954, http://dx.doi.org/10.2967/jnumed.118.223099
    Journal articles | 2019
    Professor Richard John Epstein
    Young FP; Ende D; Epstein RJ, 2019, 'Beyond BCG: The approaching era of personalised bladder-sparing therapies for non-muscle-invasive urothelial cancers', Future Oncology, vol. 15, pp. 409 - 420, http://dx.doi.org/10.2217/fon-2018-0565
    Journal articles | 2018
    Professor Richard John Epstein
    Francis PA; Pagani O; Fleming GF; Walley BA; Colleoni M; Láng I; Gómez HL; Tondini C; Ciruelos E; Burstein HJ; Bonnefoi HR; Bellet M; Martino S; Geyer CE; Goetz MP; Stearns V; Pinotti G; Puglisi F; Spazzapan S; Climent MA; Pavesi L; Ruhstaller T; Davidson NE; Coleman R; Debled M; Buchholz S; Ingle JN; Winer EP; Maibach R; Rabaglio-Poretti M; Ruepp B; Di Leo A; Coates AS; Gelber RD; Goldhirsch A; Regan MM; SOFT and TEXT Investigators and the International Breast Cancer Study Group , 2018, 'Tailoring Adjuvant Endocrine Therapy for Premenopausal Breast Cancer.', N Engl J Med, vol. 379, pp. 122 - 137, http://dx.doi.org/10.1056/NEJMoa1803164
    Journal articles | 2018
    Professor Richard John Epstein
    Smith MR; Saad F; Chowdhury S; Oudard S; Hadaschik BA; Graff JN; Olmos D; Mainwaring PN; Lee JY; Uemura H; Lopez-Gitlitz A; Trudel GC; Espina BM; Shu Y; Park YC; Rackoff WR; Yu MK; Small EJ, 2018, 'Apalutamide Treatment and Metastasis-free Survival in Prostate Cancer', New England Journal of Medicine, vol. 378, pp. 1408 - 1418, http://dx.doi.org/10.1056/nejmoa1715546
    Journal articles | 2018
    Professor Richard John Epstein
    Lin FP; Epstein RJ; Groza T; Kocbek S; Antezana E, 2018, 'Cancer care treatment outcome ontology: A novel computable ontology for profiling treatment outcomes in patients with solid tumors', JCO Clinical Cancer Informatics, vol. 2018, pp. 1 - 14, http://dx.doi.org/10.1200/CCI.18.00026
    Journal articles | 2017
    Professor Richard John Epstein
    Epstein RJ; Lin FP, 2017, 'Cancer and the omics revolution', Australian Family Physician, vol. 46, pp. 189 - 193
    Journal articles | 2017
    Professor Richard John Epstein
    Lin FPY; Pokorny A; Teng C; Epstein RJ, 2017, 'TEPAPA: A novel in silico feature learning pipeline for mining prognostic and associative factors from text-based electronic medical records', Scientific Reports, vol. 7, http://dx.doi.org/10.1038/s41598-017-07111-0
    Journal articles | 2016
    Professor Richard John Epstein
    Blackburn J; Roden DL; Ng R; Wu J; Bosman A; Epstein RJ, 2016, 'Damage-inducible intragenic demethylation of the human TP53 tumor suppressor gene is associated with transcription from an alternative intronic promoter', Molecular Carcinogenesis, vol. 55, pp. 1940 - 1951, http://dx.doi.org/10.1002/mc.22441
    Journal articles | 2016
    Professor Richard John Epstein
    Lin FPY; Pokorny A; Teng C; Dear R; Epstein RJ, 2016, 'Computational prediction of multidisciplinary team decision-making for adjuvant breast cancer drug therapies: A machine learning approach', BMC Cancer, vol. 16, http://dx.doi.org/10.1186/s12885-016-2972-z
    Journal articles | 2016
    Professor Richard John Epstein
    Epstein RJ, 2016, 'Be careful what you wish for', The Medical journal of Australia, vol. 205, pp. 521 - 522, http://dx.doi.org/10.5694/mja16.00836
    Journal articles | 2015
    Professor Richard John Epstein
    Francis PA; Regan MM; Fleming GF; Láng I; Ciruelos E; Bellet M; Bonnefoi HR; Climent MA; Da Prada GA; Burstein HJ; Martino S; Davidson NE; Geyer CE; Walley BA; Coleman R; Kerbrat P; Buchholz S; Ingle JN; Winer EP; Rabaglio-Poretti M; Maibach R; Ruepp B; Giobbie-Hurder A; Price KN; Colleoni M; Viale G; Coates AS; Goldhirsch A; Gelber RD; SOFT Investigators ; International Breast Cancer Study Group , 2015, 'Adjuvant ovarian suppression in premenopausal breast cancer.', N Engl J Med, vol. 372, pp. 436 - 446, http://dx.doi.org/10.1056/NEJMoa1412379
    Journal articles | 2015
    Professor Richard John Epstein
    Zheng S; Chan H; Epstein RJ; Joseph JE, 2015, 'Resolution of paraneoplastic immune thrombocytopenia following everolimus treatment for metastatic renal cell carcinoma', Internal Medicine Journal, vol. 45, pp. 666 - 669, http://dx.doi.org/10.1111/imj.12779
    Journal articles | 2015
    Professor Richard John Epstein
    Choueiri TK; Escudier B; Powles T; Mainwaring PN; Rini BI; Donskov F; Hammers H; Hutson TE; Lee J-L; Peltola K; Roth BJ; Bjarnason GA; Géczi L; Keam B; Maroto P; Heng DYC; Schmidinger M; Kantoff PW; Borgman-Hagey A; Hessel C; Scheffold C; Schwab GM; Tannir NM; Motzer RJ; METEOR Investigators , 2015, 'Cabozantinib versus Everolimus in Advanced Renal-Cell Carcinoma.', N Engl J Med, vol. 373, pp. 1814 - 1823, http://dx.doi.org/10.1056/NEJMoa1510016
    Journal articles | 2015
    Professor Richard John Epstein
    Epstein RJ, 2015, 'PERSONAL VIEW "By the way doctor, I've booked an African safari after my next chemo"', BMJ-BRITISH MEDICAL JOURNAL, vol. 350, http://dx.doi.org/10.1136/bmj.g7822
    Journal articles | 2015
    Professor Richard John Epstein
    Epstein RJ, 2015, 'A periodic table for cancer', Future Oncology, vol. 11, pp. 785 - 800, http://dx.doi.org/10.2217/fon.14.315
    Journal articles | 2015
    Professor Richard John Epstein
    Ding P; Tai J; Manders P; Stone E; Ho B; Epstein R, 2015, '500P Dependence of fluorodeoxyglucose avidity on tumour size in non-small cell lung cancer', Annals of Oncology, vol. 26, pp. ix153 - ix153, http://dx.doi.org/10.1093/annonc/mdv534.04
    Journal articles | 2014
    Professor Richard John Epstein
    Pagani O; Regan MM; Walley BA; Fleming GF; Colleoni M; Láng I; Gomez HL; Tondini C; Burstein HJ; Perez EA; Ciruelos E; Stearns V; Bonnefoi HR; Martino S; Geyer CE; Pinotti G; Puglisi F; Crivellari D; Ruhstaller T; Winer EP; Rabaglio-Poretti M; Maibach R; Ruepp B; Giobbie-Hurder A; Price KN; Bernhard J; Luo W; Ribi K; Viale G; Coates AS; Gelber RD; Goldhirsch A; Francis PA; TEXT and SOFT Investigators ; International Breast Cancer Study Group , 2014, 'Adjuvant exemestane with ovarian suppression in premenopausal breast cancer.', N Engl J Med, vol. 371, pp. 107 - 118, http://dx.doi.org/10.1056/NEJMoa1404037
    Journal articles | 2014
    Professor Richard John Epstein
    Connolly K; Brungs D; Szeto E; Epstein RJ, 2014, 'Anticancer activity of combination targeted therapy using cetuximab plus vemurafenib for refractory BRAFV600E-mutant metastatic colorectal carcinoma', Current Oncology, vol. 21, http://dx.doi.org/10.3747/co.21.1661
    Journal articles | 2014
    Professor Richard John Epstein
    Connolly K; Manders P; Earls P; Epstein RJ, 2014, 'Papillomavirus-associated squamous skin cancers following transplant immunosuppression: One Notch closer to control', Cancer Treatment Reviews, vol. 40, pp. 205 - 214, http://dx.doi.org/10.1016/j.ctrv.2013.08.005
    Journal articles | 2014
    Professor Richard John Epstein
    Wong H; Lau S; Cheung P; Wong TT; Parker A; Yau T; Epstein RJ, 2014, 'Lobular breast cancers lack the inverse relationship between ER/PR status and cell growth rate characteristic of ductal cancers in two independent patient cohorts: Implications for tumor biology and adjuvant therapy', BMC Cancer, vol. 14, http://dx.doi.org/10.1186/1471-2407-14-826
    Journal articles | 2014
    Professor Richard John Epstein
    Brungs D; Chen J; Masson P; Epstein RJ, 2014, 'Intermittent androgen deprivation is a rational standard-of-care treatment for all stages of progressive prostate cancer: Results from a systematic review and meta-analysis', Prostate Cancer and Prostatic Diseases, vol. 17, pp. 105 - 111, http://dx.doi.org/10.1038/pcan.2014.10
    Journal articles | 2014
    Professor Richard John Epstein
    Zhang Q; Leung R; Wong H; Chiu J; Chu KW; Poon J; Epstein RJ; Kwong YL; Yau T, 2014, 'Comparison of cetuximab and bevacizumab as first-line treatment in KRAS wild type advanced colorectal cancer patients: a retrospective analysis', EUROPEAN JOURNAL OF CANCER, vol. 50, pp. S12 - S12, http://dx.doi.org/10.1016/S0959-8049(14)70040-1
    Journal articles | 2014
    Professor Richard John Epstein
    Quah XM; Conway RM; Madigan MC; Epstein RJ, 2014, 'Emerging strategies for therapeutic targeting of the tumour microenvironment', Cancer Forum, vol. 38, pp. 133 - 137
    Journal articles | 2013
    Professor Richard John Epstein
    Chiu J; Tang V; Leung R; Wong H; Chu KW; Poon J; Epstein RJ; Yau T, 2013, 'Efficacy and tolerability of adjuvant oral capecitabine plus intravenous oxaliplatin (XELOX) in Asian patients with colorectal cancer: 4-year analysis', Asian Pacific Journal of Cancer Prevention, vol. 14, pp. 6585 - 6590, http://dx.doi.org/10.7314/APJCP.2013.14.11.6585
    Journal articles | 2013
    Professor Richard John Epstein
    Epstein RJ, 2013, 'The unpluggable in pursuit of the undruggable: Tackling the dark matter of the cancer therapeutics universe', Frontiers in Oncology, vol. 3 DEC, http://dx.doi.org/10.3389/fonc.2013.00304
    Journal articles | 2013
    Professor Richard John Epstein
    Epstein RJ, 2013, 'Has discovery-based cancer research been a bust?', Clinical and Translational Oncology, vol. 15, pp. 865 - 870, http://dx.doi.org/10.1007/s12094-013-1071-8
    Journal articles | 2013
    Professor Richard John Epstein
    Epstein CR; Epstein RJ, 2013, 'Death in The New York Times: the price of fame is a faster flame', QJM-AN INTERNATIONAL JOURNAL OF MEDICINE, vol. 106, pp. 517 - 521, http://dx.doi.org/10.1093/qjmed/hct077
    Journal articles | 2013
    Professor Richard John Epstein
    Brungs D; Sze V; Emmett L; Epstein RJ, 2013, 'Complete Radiologic Response of Bulky Cerebral Metastases From Newly Diagnosed HER2-Positive Breast Cancer to Upfront Trastuzumab-Based Chemotherapy.', World J Oncol, vol. 4, pp. 122 - 125, http://dx.doi.org/10.4021/wjon639w
    Journal articles | 2013
    Professor Richard John Epstein
    Zhao Y; Epstein RJ, 2013, 'Conserved nonsense-prone CpG sites in apoptosis-regulatory genes: Conditional stop signs on the road to cell death', Evolutionary Bioinformatics, vol. 2013, pp. 275 - 283, http://dx.doi.org/10.4137/EBO.S11759
    Journal articles | 2012
    Professor Richard John Epstein
    Campone M; Bondarenko I; Brincat S; Hotko Y; Munster PN; Chmielowska E; Fumoleau P; Ward RL; Bardy-Bouxin N; Leip E; Turnbull K; Zacharchuk C; Epstein RJ, 2012, 'Phase II study of single-agent bosutinib, a Src/Abl tyrosine kinase inhibitor, in patients with locally advanced or metastatic breast cancer pretreated with chemotherapy', Annals of Oncology, vol. 23, pp. 610 - 617, http://dx.doi.org/10.1093/annonc/mdr261
    Journal articles | 2012
    Professor Richard John Epstein
    Wong H; Lau S; Leung R; Chui J; Cheung P; Wong TT; Richard E; Yau T, 2012, 'Co-existing ductal carcinoma in situ independently predicts lower tumor aggressiveness in node-positive luminal breast cancer', Medical Oncology, vol. 29, pp. 1536 - 1542, http://dx.doi.org/10.1007/s12032-011-0082-y
    Journal articles | 2012
    Professor Richard John Epstein
    Epstein RJ; Epstein SD, 2012, 'Modernising the regulation of medical migration: moving from national monopolies to international markets.', BMC medical ethics, vol. 13, pp. 26, http://dx.doi.org/10.1186/1472-6939-13-26
    Journal articles | 2011
    Professor Richard John Epstein
    Chan W; Mak JCS; Richard E, 2011, 'Impact of income and education on drug purchasing decisions in Hong Kong Chinese cancer patients', Asian Pacific Journal of Cancer Prevention, vol. 12, pp. 2093 - 2097
    Journal articles | 2011
    Professor Richard John Epstein
    Wong H; Leung R; Lau S; Chiu J; Cheung P; Wong T; Liang R; Epstein R; Yau T, 2011, 'Presence of an in-situ component predicts reduced tumor aggressiveness in luminal subtype of invasive breast cancer', BREAST, vol. 20, pp. S39 - S39, http://dx.doi.org/10.1016/S0960-9776(11)70124-2
    Journal articles | 2011
    Professor Richard John Epstein
    Zhao YZ; Richard E, 2011, 'Unexpected functional similarities between gatekeeper tumor suppressor genes and proto-oncogenes revealed by systems biology', Journal of Human Genetics, vol. 56, pp. 369 - 376, http://dx.doi.org/10.1038/jhg.2011.21
    Journal articles | 2010
    Professor Richard John Epstein
    Wong H; Lau S; Yau T; Cheung P; Epstein RJ, 2010, 'Presence of an in situ component is associated with reduced biological aggressiveness of size-matched invasive breast cancer', British Journal of Cancer, vol. 102, pp. 1391 - 1396, http://dx.doi.org/10.1038/sj.bjc.6605655
    Journal articles | 2010
    Professor Richard John Epstein
    Hsu CH; Yang TS; Hsu C; Toh HC; Epstein RJ; Hsiao LT; Chen PJ; Lin ZZ; Chao TY; Cheng AL, 2010, 'Efficacy and tolerability of bevacizumab plus capecitabine as first-line therapy in patients with advanced hepatocellular carcinoma', British Journal of Cancer, vol. 102, pp. 981 - 986, http://dx.doi.org/10.1038/sj.bjc.6605580
    Journal articles | 2010
    Professor Richard John Epstein
    Wong H; Yau T; Chan P; Ng IOL; Chan G; Hui P; Law WL; Lo CM; Hedley AJ; Epstein RJ, 2010, 'PPI-delayed diagnosis of gastrinoma: Oncologic victim of pharmacologic success', Pathology and Oncology Research, vol. 16, pp. 87 - 91, http://dx.doi.org/10.1007/s12253-009-9192-7
    Journal articles | 2010
    Professor Richard John Epstein
    Hutson TE; Davis ID; Machiels JPH; De Souza PL; Rottey S; Hong BF; Epstein RJ; Baker KL; McCann L; Crofts T; Pandite L; Figlin RA, 2010, 'Efficacy and safety of pazopanib in patients with metastatic renal cell carcinoma', Journal of Clinical Oncology, vol. 28, pp. 475 - 480, http://dx.doi.org/10.1200/JCO.2008.21.6994
    Journal articles | 2010
    Professor Richard John Epstein
    Richard E, 2010, 'Digitization and its discontents: future shock in predictive oncology', Seminars in Oncology, vol. 37, pp. 60 - 64, http://dx.doi.org/10.1053/j.seminoncol.2009.12.006
    Journal articles | 2010
    Professor Richard John Epstein
    Epstein RJ; Tang CSM, 2010, 'Adaptive evolution hotspots at the GC-extremes of the human genome: Evidence for two functionally distinct pathways of positive selection', Advances in Bioinformatics, vol. 2010, http://dx.doi.org/10.1155/2010/856825
    Journal articles | 2010
    Professor Richard John Epstein
    Yau T; Wong H; Chan P; Chan T; Mak J; Epstein R, 2010, 'Transient carcinoembryonic antigen elevations during adjuvant chemotherapy for colorectal cancer reflect the burden of residual micrometastatic disease', Clinical Colorectal Cancer, vol. 9, pp. 108 - 112, http://dx.doi.org/10.3816/CCC.2010.n.015
    Journal articles | 2010
    Professor Richard John Epstein
    Hutson TE; Davis ID; MacHiels JP; De Souza PL; Rottey S; Hong BF; Epstein RJ; Baker KL; McCann L; Crofts T; Pandite L; Figlin RA, 2010, 'Efficacy and safety of pazopanib in patients with metastatic renal cell carcinoma', Journal of Urology, vol. 184, pp. 1303, http://dx.doi.org/10.1016/j.juro.2010.06.075
    Journal articles | 2009
    Professor Richard John Epstein
    Yau T; Chan P; Epstein R; Poon RTP, 2009, 'Management of advanced hepatocellular carcinoma in the era of targeted therapy', Liver International, vol. 29, pp. 10 - 17, http://dx.doi.org/10.1111/j.1478-3231.2008.01916.x
    Journal articles | 2009
    Professor Richard John Epstein
    Epstein RJ, 2009, 'TNM: Therapeutically Not Mandatory', European Journal of Cancer, vol. 45, pp. 1111 - 1116, http://dx.doi.org/10.1016/j.ejca.2009.02.020
    Journal articles | 2009
    Professor Richard John Epstein
    Chiu J; Yau T; Epstein RJ, 2009, 'Complications of traditional Chinese/herbal medicines (TCM)-a guide for perplexed oncologists and other cancer caregivers', Supportive Care in Cancer, vol. 17, pp. 231 - 240, http://dx.doi.org/10.1007/s00520-008-0526-x
    Journal articles | 2009
    Professor Richard John Epstein
    Epstein CR; Yam WC; Peiris JSM; Epstein RJ, 2009, 'Methicillin-resistant commensal staphylococci in healthy dogs as a potential zoonotic reservoir for community-acquired antibiotic resistance', Infection, Genetics and Evolution, vol. 9, pp. 283 - 285, http://dx.doi.org/10.1016/j.meegid.2008.11.003
    Journal articles | 2009
    Professor Richard John Epstein
    Yau T; Yao TJ; Chan P; Epstein RJ; Ng KK; Chok SH; Cheung TT; Fan ST; Poon RTP, 2009, 'The outcomes of elderly patients with hepatocellular carcinoma treated with transarterial chemoembolization', Cancer, vol. 115, pp. 5507 - 5515, http://dx.doi.org/10.1002/cncr.24636
    Journal articles | 2009
    Professor Richard John Epstein
    Xiong J; Epstein RJ, 2009, 'Growth inhibition of human cancer cells by 5-aza-2′-deoxycytidine does not correlate with its effects on INK4a/ARF expression or initial promoter methylation status', Molecular Cancer Therapeutics, vol. 8, pp. 779 - 785, http://dx.doi.org/10.1158/1535-7163.MCT-08-0926
    Journal articles | 2009
    Professor Richard John Epstein
    Epstein RJ, 2009, 'Unblocking blockbusters: Using boolean text-mining to optimise clinical trial design and timeline for novel anticancer drugs', Cancer Informatics, vol. 7, pp. 231 - 238, http://dx.doi.org/10.4137/cin.s2666
    Journal articles | 2009
    Professor Richard John Epstein
    Epstein RJ, 2009, 'Visual impairment in myopic patients with breast cancer receiving adjuvant therapy with aromatase inhibitors', Clinical Breast Cancer, vol. 9, pp. 184 - 186, http://dx.doi.org/10.3816/CBC.2009.n.030
    Journal articles | 2009
    Professor Richard John Epstein
    Wong H; Yau T; Man CW; Epstein R, 2009, 'Hoarseness during treatment with bevacizumab and other vascular endothelial growth factor signalling inhibitors', Acta Oncologica, pp. 1 - 2, http://dx.doi.org/10.1080/02841860902980453
    Journal articles | 2009
    Professor Richard John Epstein
    Wong H; Yau T; Man CW; Epstein RJ, 2009, 'Hoarseness during treatment with bevacizumab and other vascular endothelial growth factor signalling inhibitors', Acta Oncologica, vol. 48, pp. 1213 - 1215, http://dx.doi.org/10.3109/02841860902980453
    Journal articles | 2009
    Professor Richard John Epstein
    Epstein RJ; Zhao Y, 2009, 'The threat that dare not speak its name: Human extinction', Perspectives in Biology and Medicine, vol. 52, pp. 116 - 125
    Journal articles | 2008
    Professor Richard John Epstein
    Yau T; Chan P; Epstein R; Poon RT, 2008, 'Evolution of systemic therapy of advanced hepatocellular carcinoma', World Journal of Gastroenterology, vol. 14, pp. 6437 - 6441, http://dx.doi.org/10.3748/wjg.14.6437
    Journal articles | 2008
    Professor Richard John Epstein
    Yau T; Lo CY; Epstein RJ; Lam AKY; Wan KY; Lang BH, 2008, 'Treatment outcomes in anaplastic thyroid carcinoma: Survival improvement in young patients with localized disease treated by combination of surgery and radiotherapy', Annals of Surgical Oncology, vol. 15, pp. 2500 - 2505, http://dx.doi.org/10.1245/s10434-008-0005-0
    Journal articles | 2008
    Professor Richard John Epstein
    Tsang H; Yau T; Khong PL; Epstein RJ, 2008, 'Bevacizumab-based therapy for advanced small bowel adenocarcinoma', Gut, vol. 57, pp. 1631 - 1632, http://dx.doi.org/10.1136/gut.2008.153866
    Journal articles | 2008
    Professor Richard John Epstein
    Leung AWH; Mak J; Cheung PSY; Epstein RJ, 2008, 'Evidence for a programing effect of early menarche on the rise of breast cancer incidence in Hong Kong', Cancer Detection and Prevention, vol. 32, pp. 156 - 161, http://dx.doi.org/10.1016/j.cdp.2008.05.004
    Journal articles | 2008
    Professor Richard John Epstein
    Zhao Y; Epstein RJ, 2008, 'Programmed genetic instability: A tumor-permissive mechanism for maintaining the evolvability of higher species through methylation-dependent mutation of DNA repair genes in the male germ line', Molecular Biology and Evolution, vol. 25, pp. 1737 - 1749, http://dx.doi.org/10.1093/molbev/msn126
    Journal articles | 2008
    Professor Richard John Epstein
    Epstein RJ; Cheung BMY, 2008, 'Loading doses for costly cancer biologicals: Sound pharmacology or unnecessary extravagance?', European Journal of Cancer, vol. 44, pp. 1488 - 1492, http://dx.doi.org/10.1016/j.ejca.2007.12.006
    Journal articles | 2008
    Professor Richard John Epstein
    Yau T; Chan P; Ching Chan Y; Wong BCY; Liang R; Epstein RJ, 2008, 'Review article: Current management of metastatic colorectal cancer - The evolving impact of targeted drug therapies', Alimentary Pharmacology and Therapeutics, vol. 27, pp. 997 - 1005, http://dx.doi.org/10.1111/j.1365-2036.2008.03684.x
    Journal articles | 2008
    Professor Richard John Epstein
    Yau T; Leong CH; Chan WK; Chan JK; Liang RHS; Epstein RJ, 2008, 'A case of mixed adult Wilms' tumour and angiosarcoma responsive to carboplatin, etoposide and vincristine (CEO)', Cancer Chemotherapy and Pharmacology, vol. 61, pp. 717 - 720, http://dx.doi.org/10.1007/s00280-007-0529-1
    Journal articles | 2008
    Professor Richard John Epstein
    Epstein RJ; Leung TW, 2008, 'Tumor resensitization to erlotinib following brief substitution of cetuximab', Cancer Chemotherapy and Pharmacology, vol. 62, pp. 1111 - 1112, http://dx.doi.org/10.1007/s00280-008-0698-6
    Journal articles | 2007
    Professor Richard John Epstein
    Epstein RJ, 2007, 'Adjuvant breast cancer chemotherapy during late-trimester pregnancy: Not quite a standard of care', BMC Cancer, vol. 7, http://dx.doi.org/10.1186/1471-2407-7-92
    Journal articles | 2007
    Professor Richard John Epstein
    Epstein RJ; Leung TW, 2007, 'Reversing hepatocellular carcinoma progression by using networked biological therapies', Clinical Cancer Research, vol. 13, pp. 11 - 17, http://dx.doi.org/10.1158/1078-0432.CCR-06-1619
    Journal articles | 2007
    Professor Richard John Epstein
    Epstein RJ, 2007, 'VEGF signaling inhibitors: More pro-apoptotic than anti-angiogenic', Cancer and Metastasis Reviews, vol. 26, pp. 443 - 452, http://dx.doi.org/10.1007/s10555-007-9071-1
    Journal articles | 2007
    Professor Richard John Epstein
    Leung AW; Mak J; Cheung PSY; Epstein RJ, 2007, 'Clinicopathological correlates in a cohort of Hong Kong breast cancer patients presenting with screen-detected or symptomatic disease', Hong Kong Medical Journal, vol. 13, pp. 194 - 198
    Journal articles | 2007
    Professor Richard John Epstein
    Tang CSM; Epstein RJ, 2007, 'A Structural Split in the Human Genome', PLoS ONE, vol. 2, http://dx.doi.org/10.1371/journal.pone.0000603
    Journal articles | 2007
    Professor Richard John Epstein
    Yau T; Chan P; Tsang J; Liang R; Epstein R, 2007, 'XELOX causes less disabling peripheral neuropathy than FOLFOX 4 for Chinese colorectal cancer patients', Journal of Clinical Oncology, vol. 25, pp. 14592 - 14592, http://dx.doi.org/10.1200/jco.2007.25.18_suppl.14592
    Journal articles | 2007
    Professor Richard John Epstein
    Epstein RJ, 2007, 'Growth of the Asian health-care market: Global implications for the pharmaceutical industry', Nature Reviews Drug Discovery, vol. 6, pp. 785 - 792, http://dx.doi.org/10.1038/nrd2360
    Journal articles | 2006
    Professor Richard John Epstein
    Epstein RJ; Leung TWT; Cheung PSY, 2006, 'Panmucositis and chemosensitisation associated with betel quid chewing during dose-dense adjuvant breast cancer chemotherapy', Cancer Chemotherapy and Pharmacology, vol. 58, pp. 835 - 837, http://dx.doi.org/10.1007/s00280-006-0218-5
    Journal articles | 2006
    Professor Richard John Epstein
    Chan WF; Cheung PSY; Epstein RJ; Mak J, 2006, 'Multidisciplinary approach to the management of breast cancer in Hong Kong', World Journal of Surgery, vol. 30, pp. 2095 - 2100, http://dx.doi.org/10.1007/s00268-005-0370-9
    Journal articles | 2006
    Professor Richard John Epstein
    Epstein R; Leung T; Mak J; Cheung P, 2006, 'Utility of a web-based breast cancer predictive algorithm for adjuvant chemotherapeutic decision making in a multidisciplinary oncology center', Cancer Investigation, vol. 24, pp. 367 - 373, http://dx.doi.org/10.1080/07357900600705292
    Journal articles | 2006
    Professor Richard John Epstein
    Tang CS; Zhao YZ; Smith DK; Epstein RJ, 2006, 'Intron length and accelerated 3′ gene evolution', Genomics, vol. 88, pp. 682 - 689, http://dx.doi.org/10.1016/j.ygeno.2006.06.017
    Journal articles | 2006
    Professor Richard John Epstein
    Epstein RJ; Zhao Y, 2006, 'Racial differences in lung cancer [4]', New England Journal of Medicine, vol. 354, pp. 1951 - 1952, http://dx.doi.org/10.1056/NEJMc060512
    Journal articles | 2005
    Professor Richard John Epstein
    Kok LA; Diong SL; Wong WK; Epstein RJ, 2005, 'Upregulated Akt signaling adjacent to gastric cancers: Implications for screening and chemoprevention', Cancer Letters, vol. 225, pp. 53 - 59, http://dx.doi.org/10.1016/j.canlet.2004.11.021
    Journal articles | 2005
    Professor Richard John Epstein
    Epstein RJ, 2005, 'Primary prevention of human papillomavirus-dependent neoplasia: No condom, no sex', European Journal of Cancer, vol. 41, pp. 2595 - 2600, http://dx.doi.org/10.1016/j.ejca.2005.06.023
    Journal articles | 2005
    Professor Richard John Epstein
    Epstein RJ, 2005, 'Maintenance therapy to suppress micrometastasis: The new challenge for adjuvant cancer treatment', Clinical Cancer Research, vol. 11, pp. 5337 - 5341, http://dx.doi.org/10.1158/1078-0432.CCR-05-0437
    Journal articles | 2005
    Professor Richard John Epstein
    Yau TC; Chu KW; Mok MY; Liang RH; Epstein RJ, 2005, 'Acute presentation of rheumatoid arthritis following cancer chemotherapy using the topoisomerase I inhibitor irinotecan [3]', Acta Oncologica, vol. 44, pp. 771 - 772, http://dx.doi.org/10.1080/02841860500218652
    Journal articles | 2005
    Professor Richard John Epstein
    Epstein RJ, 2005, '"Leaving town" versus "taking leave": The case for re-thinking academic leave restrictions', Postgraduate Medical Journal, vol. 81, pp. 732 - 733, http://dx.doi.org/10.1136/pgmj.2005.038232
    Journal articles | 2004
    Professor Richard John Epstein
    Cheung YB; Wong LC; Tay MH; Toh CK; Koo WH; Epstein R; Goh C, 2004, 'Order effects in the assessment of quality of life in cancer patients', Quality of Life Research, vol. 13, pp. 1217 - 1223, http://dx.doi.org/10.1023/B:QURE.0000037499.80080.07
    Journal articles | 2004
    Professor Richard John Epstein
    Epstein RJ, 2004, 'Learning from the problems of problem-based learning', BMC Medical Education, vol. 4, pp. 1 - 7, http://dx.doi.org/10.1186/1472-6920-4-1
    Journal articles | 2004
    Professor Richard John Epstein
    Epstein RJ, 2004, 'The CXCL12-CXCR4 chemotactic pathway as a target of adjuvant breast cancer therapies', Nature Reviews Cancer, vol. 4, pp. 901 - 909, http://dx.doi.org/10.1038/nrc1473
    Journal articles | 2004
    Professor Richard John Epstein
    Lim YP; Wong CY; Ooi LL; Druker BJ; Epstein RJ, 2004, 'Selective tyrosine hyperphosphorylation of cytoskeletal and stress proteins in primary human breast cancers: Implications for adjuvant use of kinase-inhibitory drugs', Clinical Cancer Research, vol. 10, pp. 3980 - 3987, http://dx.doi.org/10.1158/1078-0432.CCR-03-0663
    Journal articles | 2004
    Professor Richard John Epstein
    Epstein RJ, 2004, 'Journal impact factors do not equitably reflect academic staff performance in different medical subspecialties', Journal of Investigative Medicine, vol. 52, pp. 531 - 536, http://dx.doi.org/10.1136/jim-52-08-25
    Journal articles | 2003
    Professor Richard John Epstein
    Lim YP; Diong LS; Qi R; Druker BJ; Epstein RJ, 2003, 'Phosphoproteomic fingerprinting of epidermal growth factor signaling and anticancer drug action in human tumor cells', Molecular Cancer Therapeutics, vol. 2, pp. 1369 - 1377
    Journal articles | 2003
    Professor Richard John Epstein
    Lin K; Tan SB; Kolatkar PR; Epstein RJ, 2003, 'Nonrandom Intragenic Variations in Patterns of Codon Bias Implicate a Sequential Interplay between Transitional Genetic Drift and Functional Amino Acid Selection', Journal of Molecular Evolution, vol. 57, pp. 538 - 545, http://dx.doi.org/10.1007/s00239-003-2507-5
    Journal articles | 2003
    Professor Richard John Epstein
    Cheung YB; Khoo KS; Wong ZW; See HT; Toh HC; Epstein RJ; Ng GY; Tan SB, 2003, 'Quick-FLIC: A short questionnaire for assessing quality of life of cancer patients', Acta Oncologica, vol. 42, pp. 36 - 42, http://dx.doi.org/10.1080/0891060310002212
    Journal articles | 2003
    Professor Richard John Epstein
    Epstein RJ, 2003, 'Breast self examination. Breast self examination provides entry strategy.', BMJ (Clinical research ed.), vol. 326, pp. 710
    Journal articles | 2003
    Professor Richard John Epstein
    Zammit C; Yelland A; Deutsch G; Cunnick GH; Mokbel K; Yau T; Epstein RJ; Baroni G; Pedotti A; Orecchia R; George WD; Houghton J; Ellis I; Fentiman IS; Spittle M; Tjalma WAA, 2003, 'Radiotherapy and tamoxifen in women with completely excised ductal carcinoma in situ [1] (multiple letters)', Lancet, vol. 362, pp. 1154 - 1157, http://dx.doi.org/10.1016/S0140-6736(03)14474-1
    Journal articles | 2003
    Professor Richard John Epstein
    Epstein RJ, 2003, 'Hormonal contraception and cervical cancer [13]', Lancet, vol. 361, pp. 1915, http://dx.doi.org/10.1016/S0140-6736(03)13531-3
    Journal articles | 2003
    Professor Richard John Epstein
    Epstein RJ; Manasciewicz R, 2003, 'Breast self examination [3] (multiple letters)', British Medical Journal, vol. 326, pp. 710 - 711
    Journal articles | 2002
    Professor Richard John Epstein
    Chen D; Washbrook E; Sarwar N; Bates GJ; Pace PE; Thirunuvakkarasu V; Taylor J; Epstein RJ; Fuller-Pace FV; Egly JM; Coombes RC; Ali S, 2002, 'Phosphorylation of human estrogen receptor α at serine 118 by two distinct signal transduction pathways revealed by phosphorylation-specific antisera', Oncogene, vol. 21, pp. 4921 - 4931, http://dx.doi.org/10.1038/sj.onc.1205420
    Journal articles | 2002
    Professor Richard John Epstein
    Huang GC; Hobbs S; Walton M; Epstein RJ, 2002, 'Dominant negative knockout of p53 abolishes ErbB2-dependent apoptosis and permits growth acceleration in human breast cancer cells', British Journal of Cancer, vol. 86, pp. 1104 - 1109, http://dx.doi.org/10.1038/sj.bjc.6600219
    Journal articles | 2001
    Professor Richard John Epstein
    Ouyang X; Gulliford T; Zhang H; Smith G; Huang G; Epstein RJ, 2001, 'Association of ErbB2 Ser1113 phosphorylation with epidermal growth factor receptor co-expression and poor prognosis in human breast cancer', Molecular and Cellular Biochemistry, vol. 218, pp. 47 - 54, http://dx.doi.org/10.1023/A:1007249004222
    Journal articles | 2001
    Professor Richard John Epstein
    Ouyang X; Gulliford T; Huang GC; Harper-Wynne C; Shousha S; Epstein RJ, 2001, 'Multisite phosphotyping of the ErbB-2 oncoprotein in human breast cancer', Molecular Diagnosis, vol. 6, pp. 17 - 25, http://dx.doi.org/10.2165/00066982-200106010-00003
    Journal articles | 2000
    Professor Richard John Epstein
    Epstein RJ; Lin K; Tan TW, 2000, 'A functional significance for codon third bases', Gene, vol. 245, pp. 291 - 298, http://dx.doi.org/10.1016/S0378-1119(00)00042-1
    Journal articles | 2000
    Professor Richard John Epstein
    Smith GL; Doherty AP; Banks LM; Dutton J; Hanham IW; Christmas TJ; Epstein RJ, 2000, 'Dual X-ray absorptiometry detects disease- and treatment-related alterations of bone density in prostate cancer patients', Clinical and Experimental Metastasis, vol. 18, pp. 385 - 390, http://dx.doi.org/10.1023/A:1010991213842
    Journal articles | 2000
    Professor Richard John Epstein
    Jefferson K; Dwivedi A; Persad R; Holly J; Smith GL; Epstein RJ, 2000, 'Regulatory mechanisms in prostate cancer (multiple letters)', Lancet, vol. 355, pp. 1100 - 1101, http://dx.doi.org/10.1016/S0140-6736(05)72223-6
    Journal articles | 1999
    Professor Richard John Epstein
    Ouyang X; Gulliford T; Doherty A; Cai Huang G; Epstein RJ, 1999, 'Detection of ErbB2 oversignalling in a majority of breast cancers with phosphorylation-state-specific antibodies', Lancet, vol. 353, pp. 1591 - 1592, http://dx.doi.org/10.1016/S0140-6736(99)01095-8
    Journal articles | 1999
    Professor Richard John Epstein
    Gulliford T; Ouyang X; Epstein RJ, 1999, 'Intensification of growth factor receptor signalling by phorbol treatment of ligand-primed cells implies a dimer-stabilizing effect of protein kinase C-dependent juxtamembrane domain phosphorylation', Cellular Signalling, vol. 11, pp. 245 - 252, http://dx.doi.org/10.1016/S0898-6568(98)00058-8
    Journal articles | 1999
    Professor Richard John Epstein
    Smith GL; Doherty AP; Mitchell H; Hanham IW; Christmas TJ; Epstein RJ, 1999, 'Inverse relation between prostate-specific antigen and insulin-like growth factor-binding protein 3 in bone metastases and serum of patients with prostate cancer', Lancet, vol. 354, pp. 2053 - 2054, http://dx.doi.org/10.1016/S0140-6736(99)04805-9
    Journal articles | 1999
    Professor Richard John Epstein
    Doherty A; Smith G; Banks L; Christmas T; Epstein RJ, 1999, 'Correlation of the osteoblastic phenotype with prostate-specific antigen expression in metastatic prostate cancer: Implications for paracrine growth', Journal of Pathology, vol. 188, pp. 278 - 281, http://dx.doi.org/10.1002/(SICI)1096-9896(199907)188:3<278::AID-PATH358>3.0.CO;2-G
    Journal articles | 1999
    Professor Richard John Epstein
    Huang G; Chantry A; Epstein RJ, 1999, 'Overexpression of ErbB2 impairs ligand-dependent downregulation of epidermal growth factor receptors via a post-transcriptional mechanism', Journal of Cellular Biochemistry, vol. 74, pp. 23 - 30, http://dx.doi.org/10.1002/(SICI)1097-4644(19990701)74:1<23::AID-JCB3>3.0.CO;2-L
    Journal articles | 1999
    Professor Richard John Epstein
    Ouyang X; Gulliford T; Huang G; Epstein RJ, 1999, 'Transforming growth factor-alpha short-circuits downregulation of the epidermal growth factor receptor', Journal of Cellular Physiology, vol. 179, pp. 52 - 57, http://dx.doi.org/10.1002/(SICI)1097-4652(199904)179:1<52::AID-JCP7>3.0.CO;2-M
    Journal articles | 1999
    Professor Richard John Epstein
    Epstein RJ, 1999, 'Review: Adjuvant tamoxifen reduces recurrence and improves survival in early breast cancer', Evidence-Based Medicine, vol. 4, pp. 41
    Journal articles | 1998
    Professor Richard John Epstein
    Huang GC; Ouyang X; Epstein RJ, 1998, 'Proxy activation of protein ErbB2 by heterologous ligands implies a heterotetrameric mode of receptor tyrosine kinase interaction', Biochemical Journal, vol. 331, pp. 113 - 119, http://dx.doi.org/10.1042/bj3310113
    Journal articles | 1998
    Professor Richard John Epstein
    Ouyang X; Gulliford T; Epstein RJ, 1998, 'The duration of phorbol-inducible ErbB2 tyrosine dephosphorylation parallels that of receptor endocytosis rather than threonine-686 phosphorylation: Implications for the physiological role of protein kinase C in growth factor receptor signalling', Carcinogenesis, vol. 19, pp. 2013 - 2019, http://dx.doi.org/10.1093/carcin/19.11.2013
    Journal articles | 1998
    Professor Richard John Epstein
    Ouyang X; Huang GC; Chantry A; Epstein RJ, 1998, 'Adjacent carboxyterminal tyrosine phosphorylation events identify functionally distinct ErbB2 receptor subsets: Implications for molecular diagnostics', Experimental Cell Research, vol. 241, pp. 467 - 475, http://dx.doi.org/10.1006/excr.1998.4091
    Journal articles | 1998
    Professor Richard John Epstein
    Epstein RJ, 1998, 'Bad genes, bad diseases, and bad luck', QJM - Monthly Journal of the Association of Physicians, vol. 91, pp. 861 - 864, http://dx.doi.org/10.1093/qjmed/91.12.861
    Journal articles | 1997
    Professor Richard John Epstein
    Gulliford T; Opomu M; Wilson E; Hanham I; Epstein R, 1997, 'Popularity of less frequent follow up for breast cancer in randomised study: Initial findings from the hotline study', British Medical Journal, vol. 314, pp. 174 - 177, http://dx.doi.org/10.1136/bmj.314.7075.174
    Journal articles | 1997
    Professor Richard John Epstein
    Gulliford TJ; Huang GC; Ouyang X; Epstein RJ, 1997, 'Reduced ability of transforming growth factor-alpha to induce EGF receptor heterodimerization and downregulation suggests a mechanism of oncogenic synergy with ErbB2', Oncogene, vol. 15, pp. 2219 - 2223, http://dx.doi.org/10.1038/sj.onc.1201595
    Journal articles | 1997
    Professor Richard John Epstein
    Epstein R; Hanham I; Dale R, 1997, 'Radiotherapy-induced second cancers: Are we doing enough to protect young patients?', European Journal of Cancer Part A, vol. 33, pp. 526 - 530, http://dx.doi.org/10.1016/S0959-8049(97)00056-7
    Journal articles | 1997
    Professor Richard John Epstein
    Doherty AP; Smith GL; Christmas TJ; Epstein RJ, 1997, 'The osteoblastic phenotype of metastatic prostate cancer correlates with intralesional proteolysis of IGF binding protein-3 by PSA', British Journal of Urology, vol. 79, pp. 25
    Journal articles | 1996
    Professor Richard John Epstein
    Epstein RJ; Kelly SA; Cook M; Bateman A; Paddick I; Kam KC; Dunn P; Hanham IW; Dale RG; Price PM, 1996, 'Active minimisation of radiation scatter during breast radiotherapy: Management implications for young patients with good-prognosis primary neoplasms', Radiotherapy and Oncology, vol. 40, pp. 69 - 74, http://dx.doi.org/10.1016/0167-8140(96)01760-4
    Journal articles | 1996
    Professor Richard John Epstein
    Ouyang X; Gulliford T; Zhang H; Huang GC; Epstein R, 1996, 'Human cancer cells exhibit protein kinase C-dependent c-erbB-2 transmodulation that correlates with phosphatase sensitivity and kinase activity', Journal of Biological Chemistry, vol. 271, pp. 21786 - 21792, http://dx.doi.org/10.1074/jbc.271.36.21786
    Journal articles | 1996
    Professor Richard John Epstein
    Fentiman IS; Epstein R; Barr L, 1996, 'Is routine axillary nodal dissection necessary in the treatment of breast cancer?', European Journal of Cancer Part A, vol. 32, pp. 1460 - 1461, http://dx.doi.org/10.1016/0959-8049(95)00656-7
    Journal articles | 1996
    Professor Richard John Epstein
    Epstein R, 1996, 'Treating breast cancer before surgery - Cure rates could be improved by better matching of drugs to disease', British Medical Journal, vol. 313, pp. 1345 - 1346
    Journal articles | 1996
    Professor Richard John Epstein
    Gulliford T; Epstein RJ, 1996, 'Endocrine treatment of cancer', Journal of the Royal Society of Medicine, vol. 89, pp. 448 - 453, http://dx.doi.org/10.1177/014107689608900808
    Journal articles | 1995
    Professor Richard John Epstein
    Epstein RJ, 1995, 'Preferential detection of catalytically inactive c-erbB-2 by antibodies to unphosphorylated peptides mimicking receptor tyrosine autophosphorylation sites', Oncogene, vol. 11, pp. 315 - 323
    Journal articles | 1995
    Professor Richard John Epstein
    Epstein R, 1995, 'Calcium-inducible transmodulation of receptor tyrosine kinase activity', Cellular Signalling, vol. 7, pp. 377 - 388, http://dx.doi.org/10.1016/0898-6568(95)00006-B
    Journal articles | 1995
    Professor Richard John Epstein
    Epstein RJ, 1995, 'Routine or delayed axillary dissection for primary breast cancer?', European Journal of Cancer, vol. 31, pp. 1570 - 1573, http://dx.doi.org/10.1016/0959-8049(95)00319-E
    Journal articles | 1993
    Professor Richard John Epstein
    Epstein RJ, 1993, 'Six authors in search of a citation: Villains or victims of the Vancouver convention?', British Medical Journal, vol. 306, pp. 765 - 767, http://dx.doi.org/10.1136/bmj.306.6880.765
    Journal articles | 1992
    Professor Richard John Epstein
    Epstein RJ; Druker BJ; Roberts TM; Stiles CD, 1992, 'Synthetic phosphopeptide immunogens yield activation-specific antibodies to the c-erbB-2 receptor', Proceedings of the National Academy of Sciences of the United States of America, vol. 89, pp. 10435 - 10439, http://dx.doi.org/10.1073/pnas.89.21.10435
    Journal articles | 1992
    Professor Richard John Epstein
    Epstein RJ; Druker BJ; Irminger JC; Jones SD; Roberts TM; Stiles CD, 1992, 'Extracellular calcium mimics the actions of platelet-derived growth factor on mouse fibroblasts.', Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, vol. 3, pp. 157 - 164
    Journal articles | 1992
    Professor Richard John Epstein
    Epstein RJ, 1992, 'Does the breast cancer dollar make sense?', European Journal of Cancer, vol. 28, pp. 486 - 491, http://dx.doi.org/10.1016/S0959-8049(05)80084-X
    Journal articles | 1992
    Professor Richard John Epstein
    Epstein R, 1992, 'Analysis of natural history of breast cancer in young women', The Lancet, vol. 340, pp. 1287, http://dx.doi.org/10.1016/0140-6736(92)92985-O
    Journal articles | 1990
    Professor Richard John Epstein
    Epstein RJ; Druker BJ; Roberts TM; Stiles CD, 1990, 'Modulation of a M(r) 175,000 c-neu receptor isoform in G8/DHFR cells by serum starvation', Journal of Biological Chemistry, vol. 265, pp. 10746 - 10751
    Journal articles | 1990
    Professor Richard John Epstein
    Epstein RJ, 1990, 'Drug-induced DNA damage and tumor chemosensitivity', Journal of Clinical Oncology, vol. 8, pp. 2062 - 2084, http://dx.doi.org/10.1200/JCO.1990.8.12.2062
    Journal articles | 1989
    Professor Richard John Epstein
    Epstein RJ, 1989, 'Drug wars in the United States', British Medical Journal, vol. 299, pp. 1275 - 1276, http://dx.doi.org/10.1136/bmj.299.6710.1275
    Journal articles | 1989
    Professor Richard John Epstein
    Epstein RJ; Smith PJ; Watson JV; Waters C; Bleehen NM, 1989, 'Oestrogen potentiates topoisomerase‐II‐mediated cytotoxicity in an activated subpopulation of human breast cancer cells: Implications for cytotoxic drug resistance in solid tumours', International Journal of Cancer, vol. 44, pp. 501 - 505, http://dx.doi.org/10.1002/ijc.2910440321
    Journal articles | 1989
    Professor Richard John Epstein
    Epstein RJ; Smith PJ, 1989, 'Mitogen-induced topoisomerase II synthesis precedes DNA synthesis in human breast cancer cells', Biochemical and Biophysical Research Communications, vol. 160, pp. 12 - 17, http://dx.doi.org/10.1016/0006-291X(89)91613-6
    Journal articles | 1988
    Professor Richard John Epstein
    Epstein RJ, 1988, 'The clinical biology of hormone-responsive breast cancer', Cancer Treatment Reviews, vol. 15, pp. 33 - 51, http://dx.doi.org/10.1016/0305-7372(88)90008-4
    Journal articles | 1988
    Professor Richard John Epstein
    Epstein RJ; Smith PJ; Watson JV; Bleehen NM, 1988, 'Characterisation of VP-16-induced DNA cleavage in oestrogen-stimulated human breast cancer cells', British Journal of Cancer, vol. 57, pp. 445 - 450, http://dx.doi.org/10.1038/bjc.1988.104
    Journal articles | 1988
    Professor Richard John Epstein
    Epstein RJ; Watson JV; Smith PJ, 1988, 'Subpopulation analysis of drug‐induced cell‐cycle delay in human tumor cells using 90° light scatter', Cytometry, vol. 9, pp. 349 - 358, http://dx.doi.org/10.1002/cyto.990090412
    Journal articles | 1988
    Professor Richard John Epstein
    Epstein RJ; Smith PJ, 1988, 'Estrogen-induced potentiation of dna damage and cytotoxicity in human breast cancer cells treated with topoisomerase ii-interactive antitumor drugs', Cancer Research, vol. 48, pp. 297 - 303
    Journal articles | 1988
    Professor Richard John Epstein
    Epstein RJ, 1988, 'TOPOISOMERASES IN HUMAN DISEASE', The Lancet, vol. 331, pp. 521 - 524, http://dx.doi.org/10.1016/S0140-6736(88)91308-6
    Journal articles | 1986
    Professor Richard John Epstein
    Epstein RJ, 1986, 'Is your initiator really necessary?', Journal of Theoretical Biology, vol. 122, pp. 359 - 374, http://dx.doi.org/10.1016/S0022-5193(86)80127-8
    Journal articles | 1985
    Professor Richard John Epstein
    Epstein RJ; Joshua DE; Kronenberg H, 1985, 'Idiopathic myelofibrosis complicated by lymphoma. Report of two cases.', Acta Haematol, vol. 73, pp. 40 - 44, http://dx.doi.org/10.1159/000206271
    Journal articles | 1985
    Professor Richard John Epstein
    EPSTEIN RJ; McNEILAGE LJ; GATENBY PA; HENDERSON‐SMART DJ; WHITTINGHAM SF; BASTEN A, 1985, 'INFANTILE COMPLETE HEART BLOCK ASSOCIATED WITH MATERNAL Ro(SS‐A) RIBONUCLEOPROTEIN AUTOANTIBODIES: REPORT OF TWO CASES', Australian and New Zealand Journal of Medicine, vol. 15, pp. 58 - 61, http://dx.doi.org/10.1111/j.1445-5994.1985.tb02737.x
    Journal articles | 1984
    Professor Richard John Epstein
    Epstein RJ; Ogler RF; Gatenby PA, 1984, 'Lupus erythematosus and panhypogammaglobulinemia.', Ann Intern Med, vol. 100, pp. 162 - 163, http://dx.doi.org/10.7326/0003-4819-100-1-162_3
    Journal articles | 1984
    Professor Richard John Epstein
    EPSTEIN RJ; OLIVER B; MACINTOSH PK; LEVI JA, 1984, 'COMPUTED TOMOGRAPHY OF INTRAPERITONEAL MALIGNANCY', Australian and New Zealand Journal of Medicine, vol. 14, pp. 13 - 18, http://dx.doi.org/10.1111/j.1445-5994.1984.tb03577.x
    Journal articles | 1980
    Professor Richard John Epstein
    Epstein RJ, 1980, 'What does prolactin do?', Lancet, vol. 1, pp. 264, http://dx.doi.org/10.1016/s0140-6736(80)90759-x
  • Reports | 2016
    Professor Richard John Epstein
    Shrosbree J; Pokorny A; Stone E; Epstein R; Mccormack A; Greenfield JR, 2016, Ectopic Cushing syndrome due to neuroendocrine prostatic cancer, http://dx.doi.org/10.1111/imj.13063
  • Conference Papers | 2018
    Professor Richard John Epstein
    Crumbaker M; Joshua AM; Epstein R; Emmett L, 2018, 'A phase I study of Lu-177-DKFZ PSMA 617 combined with the radiosensitizer idronoxil in men with metastatic castrate-resistant prostate cancer (mCRPC) (LuPin trial).', in JOURNAL OF CLINICAL ONCOLOGY, AMER SOC CLINICAL ONCOLOGY, http://dx.doi.org/10.1200/JCO.2018.36.15_suppl.TPS5088
    Conference Papers | 2018
    Professor Richard John Epstein
    Sternberg CN; Saad F; Graff JN; Peer A; Vaishampayan UN; Leung E; Rosenbaum E; Gurney H; Epstein R; Davis ID; Wu B; Trandafir L; Wagner VJ; Hussain M, 2018, 'A randomized phase 2 study investigating 3 dosing regimens of radium-223 dichloride (Ra-223) in bone metastatic castration-resistant prostate cancer (mCRPC).', in JOURNAL OF CLINICAL ONCOLOGY, AMER SOC CLINICAL ONCOLOGY, http://dx.doi.org/10.1200/JCO.2018.36.15_suppl.5008
    Conference Abstracts | 2018
    Professor Richard John Epstein
    Lin FP; Salih OSM; Epstein RJ, 2018, 'EXPLORATORY ANALYSIS OF CLINICAL PROGNOSTIC FACTORS IN PATIENTS WITH ADVANCED CANCER USING COMPUTATIONAL TEXT MINING OF ROUTINE DIGITISED ONCOLOGY CORRESPONDENCE', in INTERNAL MEDICINE JOURNAL, WILEY, Vol. 48, pp. 8 - 8, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000431995500009&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2018
    Professor Richard John Epstein
    Emmett L; Joshua A; Epstein R; Chalasani V; Kneebone A; Hruby G; O'Neill G; Stricker P; Stricker P; Quoc N; Ho B, 2018, 'Modulation of PSMA expression by Androgen deprivation therapy (ADT): Serial PSMA PET in men with hormone sensitive, and castrate resistant prostate cancer commencing androgen blockade', in JOURNAL OF NUCLEAR MEDICINE, SOC NUCLEAR MEDICINE INC, Philadelphia, PA, presented at Annual Meeting of the Society-of-Nuclear-Medicine-and-Molecular-Imaging (SNMMI), Philadelphia, PA, 23 June 2018 - 26 June 2018, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000467489900093&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Other | 2017
    Professor Richard John Epstein
    Fazekas-Lavu M; Parker A; Spigelman AD; Scott RJ; Epstein RJ; Jensen M; Samaras K, 2017, Thyroid cancer in a patient with lynch syndrome – case report and literature review, http://dx.doi.org/10.2147/TCRM.S121812
    Conference Abstracts | 2017
    Professor Richard John Epstein
    Lin FP-Y; Groza T; Kocbek S; Antezana E; Epstein RJ, 2017, 'The Cancer Care Treatment Outcomes Ontology (CCTO): A computable ontology for profiling treatment outcomes of patients with solid tumors.', in JOURNAL OF CLINICAL ONCOLOGY, AMER SOC CLINICAL ONCOLOGY, Chicago, IL, Vol. 35, presented at 53rd Annual Clinical Science Meeting of the American-Society-of-Clinical-Oncology (ASCO) / Symposium on Old Targets, New Drugs - Her2 and MET, Chicago, IL, 02 June 2017 - 07 June 2017, http://dx.doi.org/10.1200/JCO.2017.35.15_suppl.e18137
    Conference Abstracts | 2017
    Professor Richard John Epstein
    Lin FP-Y; Martin C; Kocbek S; Joshua AM; Dear RF-G; Lim E; Chantrill LA; Chin VT; Epstein RJ, 2017, 'Identifying determinants of quality of life in patients undergoing systemic therapy for solid tumors.', in JOURNAL OF CLINICAL ONCOLOGY, AMER SOC CLINICAL ONCOLOGY, Chicago, IL, Vol. 35, presented at 53rd Annual Clinical Science Meeting of the American-Society-of-Clinical-Oncology (ASCO) / Symposium on Old Targets, New Drugs - Her2 and MET, Chicago, IL, 02 June 2017 - 07 June 2017, http://dx.doi.org/10.1200/JCO.2017.35.15_suppl.6596
    Conference Posters | 2017
    Professor Richard John Epstein
    Joshua AM; Stricker P; Epstein RJ; Ho B; Quoc N; Kent R; Willowson KP; Hofman M; Violet JA; Emmett L, 2017, 'Patterns of failure on Ga PSMA (GaPSMA) and F18 FDG (FDG) PET CT in a prospective phase 2 trial of Lu-177 DKFZ PSMA 617 (LuPSMA) in men with castrate resistant metastatic prostate cancer (mCRPC)', Chicago, IL, Vol. 35, presented at 53rd Annual Clinical Science Meeting of the American-Society-of-Clinical-Oncology (ASCO) / Symposium on Old Targets, New Drugs - Her2 and MET, Chicago, IL, 02 June 2017 - 07 June 2017, http://dx.doi.org/10.1200/JCO.2017.35.15_suppl.2562
    Conference Abstracts | 2016
    Professor Richard John Epstein
    Lin FPY; Pokorny A; Teng C; Dear R; Epstein RJ, 2016, 'AN ALTERNATING DECISION TREE MODEL FOR PREDICTING MULTIDISCIPLINARY TEAM MEETING DECISION ABOUT ADJUVANT CHEMOTHERAPY IN EARLY BREAST CANCER PATIENTS', in ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, WILEY-BLACKWELL, Vol. 12, pp. 59 - 59, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000380005100043&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2015
    Professor Richard John Epstein
    Ding P; Tai J; Manders P; Stone E; Ho B; Epstein R, 2015, 'DEPENDENCE OF FLUORODEOXYGLUCOSE (FDG) AVIDITY ON TUMOUR SIZE IN NON-SMALL CELL LUNG CANCER (NSCLC)', in Asia-Pacific Journal of Clinical Oncology, WILEY-BLACKWELL, Vol. 11, pp. 121 - 121, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000364320800171&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2015
    Professor Richard John Epstein
    Ding P; Tai J; Manders P; Stone E; Ho B; Epstein R, 2015, 'Dependence of fluorodeoxyglucose avidity on tumour size in non-small cell lung cancer', in ANNALS OF ONCOLOGY, OXFORD UNIV PRESS, Singapore, SINGAPORE, Vol. 26, pp. 153 - 154, presented at Asia Congress of the European-Society-for-Medical-Oncology (ESMO), Singapore, SINGAPORE, 18 December 2015 - 21 December 2015, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000367158700499&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Posters | 2015
    Professor Richard John Epstein
    Manders PM; Cowley M; McCabe M; Madigan M; Munoz-Erazo L; Conway RM; Epstein RJ, 2015, 'MOLECULARLY-TARGETED AND IMMUNE STRATEGIES FOR PATIENTS WITH DRUG-RESISTANT UVEAL MELANOMA: AN UNMET AREA OF NEED IN PERSONALIZED ONCOLOGY', Vol. 11, pp. 58 - 58, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000357957300043&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Presentations | 2014
    Professor Richard John Epstein
    Blackburn J; Ng R; Roden D; Wu J; Epstein RJ, 2014, 'Damage-inducible intragenic demethylation activates transcription of an alternative intronic promoter in TP53-wildtype but not mutant human cells and tumors', Vol. 74, presented at 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR), San Diego, CA, 05 April 2014 - 09 April 2014, http://dx.doi.org/10.1158/1538-7445.AM2014-LB-85
    Conference Papers | 2012
    Professor Richard John Epstein
    Yau T; Wong H; Lau S; Leung R; Chiu J; Wong TT; Liang R; Epstein RJ; Cheung P, 2012, 'Comparison of Clinicopathologic Features of Invasive Lobular Carcinoma of the Breast with or Without Associated Lobular Carcinoma In-situ', in EUROPEAN JOURNAL OF CANCER, ELSEVIER SCI LTD, Vienna, AUSTRIA, pp. S179 - S179, presented at 8th European Breast Cancer Conference (EBCC), Vienna, AUSTRIA, 21 March 2012 - 24 March 2012, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000302804600460&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2012
    Professor Richard John Epstein
    Wong H; Lau S; Cheung P; Leung R; Chiu J; Wong TT; Liang R; Epstein RJ; Yau T, 2012, 'Ki67 Proliferation Index in Invasive Lobular Carcinoma of the Breast - Clinicopathologic Correlation and Prognostic Significance', in EUROPEAN JOURNAL OF CANCER, ELSEVIER SCI LTD, Vienna, AUSTRIA, pp. S136 - S136, presented at 8th European Breast Cancer Conference (EBCC), Vienna, AUSTRIA, 21 March 2012 - 24 March 2012, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000302804600328&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2010
    Professor Richard John Epstein
    Epstein RJ, 2010, 'INFLUENCE OF INCOME AND EDUCATION ON ANTICANCER DRUG PURCHASING DECISIONS IN HONG KONG CHINESE CANCER PATIENTS', in ANNALS OF ONCOLOGY, OXFORD UNIV PRESS, Milan, ITALY, pp. 369 - 369, presented at 35th European-Society-for-Medical-Oncology (ESMO) Congress, Milan, ITALY, 08 October 2010 - 12 October 2010, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000284592300406&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2007
    Professor Richard John Epstein
    Yau T; Chan P; Wong H; Ng KK; Chok SH; Cheung TT; Lam V; Epstein RJ; Fan ST; Poon RTP, 2007, 'Efficacy and tolerability of low-dose thalidomide as first-line systemic treatment of patients with advanced hepatocellular carcinoma', in Oncology, pp. 67 - 71, http://dx.doi.org/10.1159/000111709
    Patents | 1996
    Professor Richard John Epstein
    Epstein R; Druker B; Stiles C, 1996, Production of activation-state-specific antibodies using synthetic phosphopeptide immunogens, Patent No. 08/324421

Awards

1985-88 Sir Robert Menzies Memorial Scholarship in Medicine, to Cambridge University

1988-93 Lucille P. Markey Visiting Fellowship in Biomedical Research, to Harvard University

1993-98 Cancer Research Campaign Senior Clinical Fellowship, to Imperial College London

2003 Richard Asher Prize, Royal Society of Medicine

 

Grants

Over my career I have been awarded approximately A$10m in grants and research support. These grants included two single-applicant NIH grants, one R29 and one R01.

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