Professor Robert Brink

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Book Chapters | 2015

2015, 'The SWHEL system for high-resolution analysis of in vivo antigen-specific T-dependent B cell responses', in T Follicular Helper Cells: Methods and Protocols, pp. 103 - 123, http://dx.doi.org/10.1007/978-1-4939-2498-1_9

Book Chapters | 2011

Brink R, 2011, 'B Lymphocytes', in Immunology and Immunopathology, edn. Original, Oxford UK, http://www.eolss.net/

Book Chapters | 2010

2010, 'Regulation of B-cell self-tolerance by BAFF and the molecular basis of its action', in Cancro MP (ed.), BLys Ligands and Receptors, edn. Contemporary Immunology, Humana Press, pp. 43 - 63, http://dx.doi.org/10.1007/978-1-60327-013-7_3

Book Chapters | 2006

Basten A; Brink R, 2006, 'Tolerance and Autoimmunity: B Cells', in The Autoimmune Diseases, Fourth Edition, pp. 167 - 177, http://dx.doi.org/10.1016/B978-012595961-2/50016-0

Book Chapters | 2006

2006, 'CHAPTER 13 Tolerance and Autoimmunity: B Cells', in The Autoimmune Diseases, Elsevier, pp. 167 - 177, http://dx.doi.org/10.1016/b978-012595961-2/50016-0
Journal articles | 2023

2023, 'An epithelial cell-derived metabolite tunes immunoglobulin A secretion by gut-resident plasma cells', Nature Immunology, 24, pp. 531 - 544, http://dx.doi.org/10.1038/s41590-022-01413-w

Journal articles | 2023

2023, 'Apoptotic cell fragments locally activate tingible body macrophages in the germinal center', Cell, 186, pp. 1144 - 1161.e18, http://dx.doi.org/10.1016/j.cell.2023.02.004

Journal articles | 2023

2023, 'CARD11 gain-of-function mutation drives cell-autonomous accumulation of PD-1⁺ ICOS^high activated T cells, T-follicular, T-regulatory and T-follicular regulatory cells', Frontiers in Immunology, 14, http://dx.doi.org/10.3389/fimmu.2023.1095257

Journal articles | 2023

2023, 'Human PIK3R1 mutations disrupt lymphocyte differentiation to cause activated PI3Kδ syndrome 2', The Journal of experimental medicine, 220, http://dx.doi.org/10.1084/jem.20221020

Journal articles | 2023

2023, 'Skin γδ T cell inflammatory responses are hardwired in the thymus by oxysterol sensing via GPR183 and calibrated by dietary cholesterol', Immunity, 56, pp. 562 - 575.e6, http://dx.doi.org/10.1016/j.immuni.2023.01.025

Journal articles | 2023

2023, 'Synonymous alterations of cancer-associated Trp53 CpG mutational hotspots cause fatal developmental jaw malocclusions but no tumors in knock-in mice', PLoS ONE, 18, pp. e0284327, http://dx.doi.org/10.1371/journal.pone.0284327

Journal articles | 2023

2023, 'β-cell function is regulated by metabolic and epigenetic programming of islet-associated macrophages, involving Axl, Mertk, and TGFβ receptor signaling', iScience, 26, pp. 106477 - 106477, http://dx.doi.org/10.1016/j.isci.2023.106477

Journal articles | 2022

2022, 'Analysing the cellular mechanisms underlying activated PI3K δ Syndrome (APDS) reveals differences between APDS1 and APDS2', The Journal of Immunology, 208, pp. 159.15 - 159.15, http://dx.doi.org/10.4049/jimmunol.208.supp.159.15

Journal articles | 2022

2022, 'Blocking AMPK β1 myristoylation enhances AMPK activity and protects mice from high-fat diet-induced obesity and hepatic steatosis', Cell Reports, 41, http://dx.doi.org/10.1016/j.celrep.2022.111862

Journal articles | 2022

2022, 'Epithelial-derived oxysterol production tunes intestinal IgA secretion against commensals and enteric pathogen in tissue', The Journal of Immunology, 208, pp. 115.07 - 115.07, http://dx.doi.org/10.4049/jimmunol.208.supp.115.07

Journal articles | 2022

2022, 'IL-21 has a critical role in establishing germinal centers by amplifying early B cell proliferation', EMBO Reports, 23, http://dx.doi.org/10.15252/embr.202254677

Journal articles | 2022

2022, 'Increased core body temperature exacerbates defective protein prenylation in mouse models of mevalonate kinase deficiency', Journal of Clinical Investigation, 132, http://dx.doi.org/10.1172/JCI160929

Journal articles | 2022

2022, 'Interleukin-21, acting beyond the immunological synapse, independently controls T follicular helper and germinal center B cells', Immunity, 55, pp. 1414 - 1430.e5, http://dx.doi.org/10.1016/j.immuni.2022.06.020

Journal articles | 2022

2022, 'Mesoderm-derived PDGFRA⁺ cells regulate the emergence of hematopoietic stem cells in the dorsal aorta', Nature Cell Biology, 24, pp. 1211 - 1225, http://dx.doi.org/10.1038/s41556-022-00955-3

Journal articles | 2022

2022, 'STAT3 gain-of-function mutations connect leukemia with autoimmune disease by pathological NKG2D^hi CD8⁺ T cell dysregulation and accumulation', Immunity, 55, pp. 2386 - 2404.e8, http://dx.doi.org/10.1016/j.immuni.2022.11.001

Journal articles | 2022

2022, 'T cell extrinsic mechanics explaining the T cell hyperactivation seen in Activated PI3K δ Syndrome', The Journal of Immunology, 208, pp. 159.05 - 159.05, http://dx.doi.org/10.4049/jimmunol.208.supp.159.05

Journal articles | 2022

2022, 'The retroelement Lx9 puts a brake on the immune response to virus infection', Nature, 608, pp. 757 - 765, http://dx.doi.org/10.1038/s41586-022-05054-9

Journal articles | 2021

2021, 'BAFFR controls early memory B cell responses but is dispensable for germinal center function', Journal of Experimental Medicine, 218, http://dx.doi.org/10.1084/JEM.20191167

Journal articles | 2021

2021, 'Erratum: Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption (Cell (2021) 184(5) (1330–1347.e13), (S0092867421001525), (10.1016/j.cell.2021.02.002))', Cell, 184, pp. 1940, http://dx.doi.org/10.1016/j.cell.2021.03.010

Journal articles | 2021

2021, 'Immunizations with diverse sarbecovirus receptor-binding domains elicit SARS-CoV-2 neutralizing antibodies against a conserved site of vulnerability', Immunity, 54, pp. 2908 - 2921.e6, http://dx.doi.org/10.1016/j.immuni.2021.10.019

Journal articles | 2021

2021, 'Loss-of-function of Fbxo10, encoding a post-translational regulator of BCL2 in lymphomas, has no discernible effect on BCL2 or B lymphocyte accumulation in mice', PLoS ONE, 16, pp. e0237830, http://dx.doi.org/10.1371/journal.pone.0237830

Journal articles | 2021

2021, 'Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption', Cell, 184, pp. 1330 - 1347.e13, http://dx.doi.org/10.1016/j.cell.2021.02.002

Journal articles | 2021

2021, 'Osteocyte transcriptome mapping identifies a molecular landscape controlling skeletal homeostasis and susceptibility to skeletal disease', Nature Communications, 12, pp. 2444, http://dx.doi.org/10.1038/s41467-021-22517-1

Journal articles | 2021

2021, 'Positive selection of IgG⁺ over IgM⁺ B cells in the germinal center reaction', Immunity, 54, pp. 988 - 1001.e5, http://dx.doi.org/10.1016/j.immuni.2021.03.013

Journal articles | 2021

2021, 'Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1 antibodies', mAbs, 13, pp. 1922134, http://dx.doi.org/10.1080/19420862.2021.1922134

Journal articles | 2021

2021, 'The unique biology of germinal center B cells', Immunity, 54, pp. 1652 - 1664, http://dx.doi.org/10.1016/j.immuni.2021.07.015

Journal articles | 2020

2020, 'A Future Outlook on Molecular Mechanisms of Immunity', Trends in Immunology, 41, pp. 549 - 555, http://dx.doi.org/10.1016/j.it.2020.05.005

Journal articles | 2020

2020, 'Activated PI3Kd breaches multiple B cell tolerance checkpoints and causes autoantibody production', Journal of Experimental Medicine, 217, http://dx.doi.org/10.1084/jem_20191336

Journal articles | 2020

2020, 'Conformational diversity facilitates antibody mutation trajectories and discrimination between foreign and self-antigens', Proceedings of the National Academy of Sciences of the United States of America, 117, pp. 22341 - 22350, http://dx.doi.org/10.1073/pnas.2005102117

Journal articles | 2020

2020, 'Genetic loss of AMPK-glycogen binding destabilises AMPK and disrupts metabolism', Molecular Metabolism, 41, http://dx.doi.org/10.1016/j.molmet.2020.101048

Journal articles | 2020

2020, 'Germinal centers and autoantibodies', Immunology and Cell Biology, 98, pp. 480 - 489, http://dx.doi.org/10.1111/imcb.12321

Journal articles | 2020

2020, 'Lymphoma Driver Mutations in the Pathogenic Evolution of an Iconic Human Autoantibody', Cell, 180, pp. 878 - 894.e19, http://dx.doi.org/10.1016/j.cell.2020.01.029

Journal articles | 2020

2020, 'Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1 antibodies', , http://dx.doi.org/10.1101/2020.12.14.422791

Journal articles | 2020

2020, 'Restriction of memory b cell differentiation at the germinal center b cell positive selection stage', Journal of Experimental Medicine, 217, http://dx.doi.org/10.1084/jem.20191933

Journal articles | 2020

2020, 'Selection in the germinal center', Current Opinion in Immunology, 63, pp. 29 - 34, http://dx.doi.org/10.1016/j.coi.2019.11.001

Journal articles | 2020

2020, 'The effects of germline STAT3-activating mutations from autoimmunity and lymphoid malignancy on mouse and human T cells', The Journal of Immunology, 204, pp. 142.35 - 142.35, http://dx.doi.org/10.4049/jimmunol.204.supp.142.35

Journal articles | 2019

2019, 'Activating mutations in PIK3CD disrupt the differentiation and function of human and murine CD4⁺ T cells', Journal of Allergy and Clinical Immunology, 144, pp. 236 - 253, http://dx.doi.org/10.1016/j.jaci.2019.01.033

Journal articles | 2019

2019, 'B cell–intrinsic requirement for STK4 in humoral immunity in mice and human subjects', Journal of Allergy and Clinical Immunology, 143, pp. 2302 - 2305, http://dx.doi.org/10.1016/j.jaci.2019.02.010

Journal articles | 2019

2019, 'Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity', Nature Immunology, 20, pp. 1299 - 1310, http://dx.doi.org/10.1038/s41590-019-0492-0

Journal articles | 2019

2019, 'Phospho-tuning immunity through Denisovan, modern human and mouse TNFAIP3 gene variants', bioRxiv, http://dx.doi.org/10.1101/589507

Journal articles | 2018

Avery DT; Kane A; Nguyen T; Lau A; Nguyen A; Lenthall H; Payne K; Shi W; Brigden H; French E; Bier J; Hermes JR; Zahra D; Sewell WA; Butt D; Elliott M; Boztug K; Meyts I; Choo S; Hsu P; Wong M; Berglund LJ; Gray P; Oâ€™Sullivan M; Cole T; Holland SM; Ma CS; Burkhart C; Corcoran LM; Phan TG; Brink R; Uzel G; Deenick EK; Tangye SG, 2018, 'Germline-activating mutations in PIK3CD compromise B cell development and function', Journal of Experimental Medicine, 215, pp. 2073 - 2095, http://dx.doi.org/10.1084/jem.20180010

Journal articles | 2018

Brink R; Phan TG, 2018, 'Self-Reactive B Cells in the Germinal Center Reaction', Annual Review of Immunology, 36, pp. 339 - 357, http://dx.doi.org/10.1146/annurev-immunol-051116-052510

Journal articles | 2018

Burnett DL; Langley DB; Schofield P; Hermes JR; Chan TD; Jackson J; Bourne K; Reed JH; Patterson K; Porebski BT; Brink R; Christ D; Goodnow CC, 2018, 'Germinal center antibody mutation trajectories are determined by rapid self/foreign discrimination', Science, 360, pp. 223 - 226, http://dx.doi.org/10.1126/science.aao3859

Journal articles | 2018

Byrne FL; Olzomer EM; Brink R; Hoehn KL, 2018, 'Knockout of glucose transporter GLUT6 has minimal effects on whole body metabolic physiology in mice', American Journal of Physiology - Endocrinology and Metabolism, 315, pp. E286 - E293, http://dx.doi.org/10.1152/ajpendo.00082.2018

Journal articles | 2018

Kara EE; Bastow CR; McKenzie DR; Gregor CE; Fenix KA; Babb R; Norton TS; Zotos D; Rodda LB; Hermes JR; Bourne K; Gilchrist DS; Nibbs RJ; Alsharifi M; Vinuesa CG; Tarlinton DM; Brink R; Hill GR; Cyster JG; Comerford I; McColl SR, 2018, 'Atypical chemokine receptor 4 shapes activated B cell fate', Journal of Experimental Medicine, 215, pp. 801 - 813, http://dx.doi.org/10.1084/jem.20171067

Journal articles | 2018

Moran I; Nguyen A; Khoo WH; Butt D; Bourne K; Young C; Hermes JR; Biro M; Gracie G; Ma CS; Munier CM L; Luciani F; Zaunders J; Parker A; Kelleher AD; Tangye SG; Croucher PI; Brink R; Read MN; Phan TG, 2018, 'Memory B cells are reactivated in subcapsular proliferative foci of lymph nodes', Nature Communications, 9, http://dx.doi.org/10.1038/s41467-018-05772-7

Journal articles | 2018

Thientosapol ES; Bosnjak D; Durack T; Stevanovski I; Van Geldermalsen M; Holst J; Jahan Z; Shepard C; Weninger W; Kim B; Brink R; Jolly CJ, 2018, 'SAMHD1 enhances immunoglobulin hypermutation by promoting transversion mutation', Proceedings of the National Academy of Sciences of the United States of America, 115, pp. 4921 - 4926, http://dx.doi.org/10.1073/pnas.1719771115

Journal articles | 2018

Wirasinha RC; Vijayan D; Smith NJ; Parnell GP; Swarbrick A; Brink R; King C; Stewart G; Booth DR; Batten M, 2018, 'GPR65 inhibits experimental autoimmune encephalomyelitis through CD4⁺ T cell independent mechanisms that include effects on iNKT cells', Immunology and Cell Biology, 96, pp. 128 - 136, http://dx.doi.org/10.1111/imcb.1031

Journal articles | 2017

Burnett DL; Parish IA; Masle-Farquhar E; Brink R; Goodnow CC, 2017, 'Murine LRBA deficiency causes CTLA-4 deficiency in Tregs without progression to immune dysregulation', Immunology and Cell Biology, 95, pp. 775 - 788, http://dx.doi.org/10.1038/icb.2017.50

Journal articles | 2017

Corpuz TM; Vazquez-Lombardi R; Luong JK; Warren J; Stolp J; Christ D; King C; Brink R; Sprent J; Webster KE, 2017, 'IL-2 shapes the survival and plasticity of IL-17-producing γδ T Cells', Journal of Immunology, 199, pp. 2366 - 2376, http://dx.doi.org/10.4049/jimmunol.1700335

Journal articles | 2017

KrÃ¤utler NJ; Suan D; Butt D; Bourne K; Hermes JR; Chan TD; Sundling C; Kaplan W; Schofield P; Jackson J; Basten A; Christ D; Brink R, 2017, 'Differentiation of germinal center B cells into plasma cells is initiated by high-affinity antigen and completed by Tfh cells', Journal of Experimental Medicine, 214, pp. 1259 - 1267, http://dx.doi.org/10.1084/jem.20161533

Journal articles | 2017

Langley DB; Crossett B; Schofield P; Jackson J; Zeraati M; Maltby D; Christie M; Burnett D; Brink R; Goodnow C; Christ D, 2017, 'Structural basis of antigen recognition: Crystal structure of duck egg lysozyme', Acta Crystallographica Section D: Structural Biology, 73, pp. 910 - 920, http://dx.doi.org/10.1107/S2059798317013730

Journal articles | 2017

Suan D; KrÃ¤utler NJ; Maag JL V; Butt D; Bourne K; Hermes JR; Avery DT; Young C; Statham A; Elliott M; Dinger ME; Basten A; Tangye SG; Brink R, 2017, 'CCR6 Defines Memory B Cell Precursors in Mouse and Human Germinal Centers, Revealing Light-Zone Location and Predominant Low Antigen Affinity', Immunity, 47, pp. 1142 - 1153.e4, http://dx.doi.org/10.1016/j.immuni.2017.11.022

Journal articles | 2017

Suan D; Sundling C; Brink R, 2017, 'Plasma cell and memory B cell differentiation from the germinal center', Current Opinion in Immunology, 45, pp. 97 - 102, http://dx.doi.org/10.1016/j.coi.2017.03.006

Journal articles | 2017

Torcellan T; Hampton HR; Bailey J; Tomura M; Brink R; Chtanova T, 2017, 'In vivo photolabeling of tumor-infiltrating cells reveals highly regulated egress of T-cell subsets from tumors', Proceedings of the National Academy of Sciences of the United States of America, 114, pp. 5677 - 5682, http://dx.doi.org/10.1073/pnas.1618446114

Journal articles | 2017

Villa M; Gialitakis M; Tolaini M; Ahlfors H; Henderson CJ; Wolf CR; Brink R; Stockinger B, 2017, 'Aryl hydrocarbon receptor is required for optimal B-cell proliferation', EMBO Journal, 36, pp. 116 - 128, http://dx.doi.org/10.15252/embj.201695027

Journal articles | 2017

Villanueva JE; Walters SN; Saito M; Malle EK; Zammit NW; Watson KA; Brink R; La Gruta NL; Alexander SI; Grey ST, 2017, 'Targeted deletion of Traf2 allows immunosuppression-free islet allograft survival in mice', Diabetologia, 60, pp. 679 - 689, http://dx.doi.org/10.1007/s00125-016-4198-7

Journal articles | 2017

2017, 'Erratum: Antigen-affinity controls pre-germinal center B cell selection by promoting Mcl-1 induction through BAFF receptor signaling', Scientific reports, 7, pp. 39366, http://dx.doi.org/10.1038/srep39366

Journal articles | 2016

Brink R, 2016, 'EBI2 unlocks the door to the Tfh cell nursery', Immunology and Cell Biology, 94, pp. 621 - 622, http://dx.doi.org/10.1038/icb.2016.52

Journal articles | 2016

Chevalier N; Macia L; Tan JK; Mason LJ; Robert R; Thorburn AN; Wong CH Y; Tsai LM; Bourne K; Brink R; Yu D; Mackay CR, 2016, 'The Role of Follicular Helper T Cell Molecules and Environmental Influences in Autoantibody Production and Progression to Inflammatory Arthritis in Mice', Arthritis and Rheumatology, 68, pp. 1026 - 1038, http://dx.doi.org/10.1002/art.39481

Journal articles | 2016

Guy TV; Terry AM; Bolton HA; Hancock DG; Zhu E; Brink R; McGuire HM; Shklovskaya E; Fazekas De St Groth B, 2016, 'Collaboration between tumor-specific CD4⁺ T cells and B cells in anti-cancer immunity', Oncotarget, 7, pp. 30211 - 30229, http://dx.doi.org/10.18632/oncotarget.8797

Journal articles | 2016

Jung S; Schickel JN; Kern A; Knapp AM; Eftekhari P; Da Silva S; Jaulhac B; Brink R; Soulas-Sprauel P; Pasquali JL; Martin T; Korganow AS, 2016, 'Chronic bacterial infection activates autoreactive B cells and induces isotype switching and autoantigen-driven mutations', European Journal of Immunology, 46, pp. 131 - 146, http://dx.doi.org/10.1002/eji.201545810

Journal articles | 2016

Kane A; Lau A; Brink R; Tangye SG; Deenick EK, 2016, 'B-cell–specific STAT3 deficiency: Insight into the molecular basis of autosomal-dominant hyper-IgE syndrome', Journal of Allergy and Clinical Immunology, 138, pp. 1455 - 1458.e3, http://dx.doi.org/10.1016/j.jaci.2016.05.018

Journal articles | 2016

Vijayan D; Redzwan NM; Avery DT; Wirasinha RC; Brink R; Walters G; Adelstein S; Kobayashi M; Gray P; Elliott M; Wong M; King C; Vinuesa CG; Ghilardi N; Ma CS; Tangye SG; Batten M, 2016, 'IL-27 Directly Enhances Germinal Center B Cell Activity and Potentiates Lupus in Sanroque Mice', Journal of Immunology, 197, pp. 3008 - 3017, http://dx.doi.org/10.4049/jimmunol.1600652

Journal articles | 2016

Wensveen FM; Slinger E; Van Attekum MH A; Brink R; Eldering E, 2016, 'Antigen-affinity controls pre-germinal centser B cell selection by promoting Mcl-1 induction through BAFF receptor signaling', Scientific Reports, 6, http://dx.doi.org/10.1038/srep35673

Journal articles | 2016

2016, 'MicroRNA-155 controls affinity-based selection by protecting c-MYC+B cells from apoptosis', Journal of Clinical Investigation, 126, pp. 377 - 388, http://dx.doi.org/10.1172/JCI82914

Journal articles | 2015

Brink R; Paus D; Bourne K; Hermes JR; Gardam S; Phan TG; Chan TD, 2015, 'The SWHEL system for high-resolution analysis of in vivo antigen-specific T-dependent B cell responses', Methods in Molecular Biology, 1291, pp. 103 - 123, http://dx.doi.org/10.1007/978-1-4939-2498-1_9

Journal articles | 2015

Chen Z; Shen H; Sun C; Yin L; Tang F; Zheng P; Liu Y; Brink R; Rui L, 2015, 'Myeloid cell TRAF3 promotes metabolic inflammation, insulin resistance, and hepatic steatosis in obesity', American Journal of Physiology - Endocrinology and Metabolism, 308, pp. E460 - E469, http://dx.doi.org/10.1152/ajpendo.00470.2014

Journal articles | 2015

Hampton HR; Bailey J; Tomura M; Brink R; Chtanova T, 2015, 'Microbe-dependent lymphatic migration of neutrophils modulates lymphocyte proliferation in lymph nodes', Nature Communications, 6, http://dx.doi.org/10.1038/ncomms8139

Journal articles | 2015

Jung S; Schickel JN; Kern A; Knapp AM; Eftekhari P; Da Silva S; Jaulhac B; Brink R; Soulas-Sprauel P; Pasquali JL; Martin T; Korganow AS, 2015, 'Chronic bacterial infection activates autoreactive B cells and induces isotype switching and autoantigen-driven mutations', European Journal of Immunology, http://dx.doi.org/10.1002/eji.201545810

Journal articles | 2015

Malle EK; Zammit NW; Walters SN; Koay YC; Wu J; Tan BM; Villanueva JE; Brink R; Loudovaris T; Cantley J; McAlpine SR; Hesselson D; Grey ST, 2015, 'Nuclear factor κB-inducing kinase activation as a mechanism of pancreatic β cell failure in obesity', Journal of Experimental Medicine, 212, pp. 1239 - 1254, http://dx.doi.org/10.1084/jem.20150218

Journal articles | 2015

McGuire HM; Vogelzang A; Warren J; Loetsch C; Natividad KD; Chan TD; Brink R; Batten M; King C, 2015, 'IL-21 and IL-4 collaborate to shape t-dependent antibody responses', Journal of Immunology, 195, pp. 5123 - 5135, http://dx.doi.org/10.4049/jimmunol.1501463

Journal articles | 2015

Tangye SG; Brink R; Goodnow CC; Phan TG, 2015, 'SnapShot: Interactions between B Cells and T Cells', Cell, 162, pp. 926 - 926.e1, http://dx.doi.org/10.1016/j.cell.2015.07.055

Journal articles | 2015

Villanueva JE; Malle EK; Gardam S; Silveira PA; Zammit NW; Walters SN; Brink R; Grey ST, 2015, 'TRAF2 regulates peripheral CD8⁺ T-cell and NKT-cell homeostasis by modulating sensitivity to IL-15', European Journal of Immunology, http://dx.doi.org/10.1002/eji.201445416

Journal articles | 2015

Villanueva JE; Malle EK; Gardam S; Silveira PA; Zammit NW; Walters SN; Brink R; Grey ST, 2015, 'TRAF2 regulates peripheral CD8⁺ T-cell and NKT-cell homeostasis by modulating sensitivity to IL-15', European Journal of Immunology, 45, pp. 1820 - 1831, http://dx.doi.org/10.1002/eji.201445416

Journal articles | 2015

2015, 'FAS Inactivation Releases Unconventional Germinal Center B Cells that Escape Antigen Control and Drive IgE and Autoantibody Production', Immunity, 42, pp. 890 - 902, http://dx.doi.org/10.1016/j.immuni.2015.04.010

Journal articles | 2015

2015, 'T Follicular Helper Cells Have Distinct Modes of Migration and Molecular Signatures in Naive and Memory Immune Responses', Immunity, 42, pp. 704 - 718, http://dx.doi.org/10.1016/j.immuni.2015.03.002

Journal articles | 2014

Brink R, 2014, 'LOX-1Unlocks Human Plasma Cell Potential', Immunity, 41, pp. 507 - 508, http://dx.doi.org/10.1016/j.immuni.2014.09.019

Journal articles | 2014

Brink R, 2014, 'The imperfect control of self-reactive germinal center B cells', Current Opinion in Immunology, 28, pp. 97 - 101, http://dx.doi.org/10.1016/j.coi.2014.03.001

Journal articles | 2014

Chang JH; Hu H; Jin J; Puebla-Osorio N; Xiao Y; Gilbert BE; Brink R; Ullrich SE; Sun SC, 2014, 'TRAF3 regulates the effector function of regulatory T cells and humoral immune responses', Journal of Experimental Medicine, 211, pp. 137 - 151, http://dx.doi.org/10.1084/jem.20131019

Journal articles | 2014

Chen Z; Brink R; Rui L, 2014, 'Deletion of TRAF3 in Myeloid Cells Ameliorates Dietary Insulin Resistance and Glucose Intolerance in Mice', ENDOCRINE REVIEWS, 35, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209805103127&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Journal articles | 2014

Chtanova T; Hampton HR; Waterhouse LA; Wood K; Tomura M; Miwa Y; Mackay CR; Brink R; Phan TG, 2014, 'Real-time interactive two-photon photoconversion of recirculating lymphocytes for discontinuous cell tracking in live adult mice', Journal of Biophotonics, 7, pp. 425 - 433, http://dx.doi.org/10.1002/jbio.201200175

Journal articles | 2014

Heinig K; GÃ¤tjen M; Grau M; Stache V; Anagnostopoulos I; Gerlach K; Niesner RA; Cseresnyes Z; Hauser AE; Lenz P; Hehlgans T; Brink R; Westermann J; DÃ¶rken B; Lipp M; Lenz G; Rehm A; HÃ¶pken UE, 2014, 'Access to follicular dendritic cells is a pivotal step in murine chronic lymphocytic leukemia b-cell activation and proliferation', Cancer Discovery, 4, pp. 1448 - 1465, http://dx.doi.org/10.1158/2159-8290.CD-14-0096

Journal articles | 2014

Malle EK; Tan BM; Walters SN; Zammit NW; Brink R; Cantley J; Grey ST, 2014, 'The non-canonical NF kappa B pathway as a novel player in beta cell dysfunction in diabetes', DIABETOLOGIA, 57, pp. S48 - S48, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000344386100098&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Journal articles | 2014

Sabouri Z; Schofield P; Horikawa K; Spierings E; Kipling D; Randall KL; Langley D; Roome B; Vazquez-Lombardi R; Rouet R; Hermes J; Chan TD; Brink R; Dunn-Walters DK; Christ D; Goodnow CC, 2014, 'Redemption of autoantibodies on anergic B cells by variable-region glycosylation and mutation away from self-reactivity', Proceedings of the National Academy of Sciences of the United States of America, 111, http://dx.doi.org/10.1073/pnas.1406974111

Journal articles | 2014

Webster KE; Kim HO; Kyparissoudis K; Corpuz TM; Pinget GV; Uldrich AP; Brink R; Belz GT; Cho JH; Godfrey DI; Sprent J, 2014, 'IL-17-producing NKT cells depend exclusively on IL-7 for homeostasis and survival', Mucosal Immunology, 7, pp. 1058 - 1067, http://dx.doi.org/10.1038/mi.2013.122

Journal articles | 2013

Gardam S; Brink R, 2013, 'Non-canonical NF-κB signaling initiated by BAFF influences B cell biology at multiple junctures', Frontiers in Immunology, 4, http://dx.doi.org/10.3389/fimmu.2013.00509

Journal articles | 2013

Gardam S; Brink R, 2013, 'Non-canonical NF-κB signaling initiated by BAFF influences B cell biology at multiple junctures', Frontiers in Immunology, 4, http://dx.doi.org/10.3389/fimmu.2014.00509

Journal articles | 2013

Gatto D; Brink R, 2013, 'B cell localization: Regulation by EBI2 and its oxysterol ligand', Trends in Immunology, 34, pp. 336 - 341, http://dx.doi.org/10.1016/j.it.2013.01.007

Journal articles | 2013

Gatto D; Wood K; Caminschi I; Murphy-Durland D; Schofield P; Christ D; Karupiah G; Brink R, 2013, 'Erratum: The chemotactic receptor EBI2 regulates the homeostasis, localization and immunological function of splenic dendritic cells (Nature Immunology (2013) 14 (446-453))', Nature Immunology, 14, pp. 876, http://dx.doi.org/10.1038/ni0813-876e

Journal articles | 2013

He J; Tsai LM; Leong YA; Hu X; Ma CS; Chevalier N; Sun X; Vandenberg K; Rockman S; Ding Y; Zhu L; Wei W; Wang C; Karnowski A; Belz GT; Ghali JR; Cook MC; Riminton DS; Veillette A; Schwartzberg PL; Mackay F; Brink R; Tangye SG; Vinuesa CG; Mackay CR; Li Z; Yu D, 2013, 'Circulating precursor CCR7^loPD-1^hi CXCR5⁺ CD4⁺ T cells indicate tfh cell activity and promote antibody responses upon antigen reexposure', Immunity, 39, pp. 770 - 781, http://dx.doi.org/10.1016/j.immuni.2013.09.007

Journal articles | 2013

Wheeler ML; Dong MB; Brink R; Zhong XP; De Franco AL, 2013, 'Diacylglycerol kinase ζ limits B cell antigen receptor-dependent activation of ERK Signaling to inhibit early antibody responses', Science Signaling, 6, http://dx.doi.org/10.1126/scisignal.2004189

Journal articles | 2013

Xiao Y; Jin J; Chang M; Chang JH; Hu H; Zhou X; Brittain GC; Stansberg C; Torkildsen Ã˜; Wang X; Brink R; Cheng X; Sun SC, 2013, 'Peli1 promotes microglia-mediated CNS inflammation by regulating Traf3 degradation', Nature Medicine, 19, pp. 595 - 602, http://dx.doi.org/10.1038/nm.3111

Journal articles | 2013

2013, 'Censoring of self-reactive B cells by follicular dendritic cell-displayed self-antigen', Journal of Immunology, 191, pp. 1082 - 1090, http://dx.doi.org/10.4049/jimmunol.1201569

Journal articles | 2013

2013, 'Interleukin-27 Signaling Promotes Immunity against Endogenously Arising Murine Tumors', PLoS ONE, 8, pp. e57469, http://dx.doi.org/10.1371/journal.pone.0057469

Journal articles | 2013

2013, 'The chemotactic receptor EBI2 regulates the homeostasis, localization and immunological function of splenic dendritic cells', Nature Immunology, 14, pp. 446 - 453, http://dx.doi.org/10.1038/ni.2555

Journal articles | 2013

2013, 'The good, the bad and the ugly-T FH cells in human health and disease', Nature Reviews Immunology, 13, pp. 412 - 426, http://dx.doi.org/10.1038/nri3447

Journal articles | 2013

2013, 'Transcriptional Regulation of Germinal Center B and Plasma Cell Fates by Dynamical Control of IRF4', Immunity, 38, pp. 918 - 929, http://dx.doi.org/10.1016/j.immuni.2013.04.009

Journal articles | 2012

Villanueva J; Walters SN; Marino E; Brink R; Grey ST, 2012, 'TRAF2 Governs the T Cell Alloimmune Response', TRANSPLANTATION, 94, pp. 14 - 14, http://dx.doi.org/10.1097/00007890-201211271-00025

Journal articles | 2012

2012, 'A helping hand from neutrophils in T cell-independent antibody responses?', Nature Immunology, 13, pp. 111 - 113, http://dx.doi.org/10.1038/ni.2214

Journal articles | 2012

2012, 'Affinity-based selection and the germinal center response', Immunological Reviews, 247, pp. 11 - 23, http://dx.doi.org/10.1111/j.1600-065X.2012.01118.x

Journal articles | 2012

2012, 'Follicular dendritic cells emerge from ubiquitous perivascular precursors', Cell, 150, pp. 194 - 206, http://dx.doi.org/10.1016/j.cell.2012.05.032

Journal articles | 2012

2012, 'Hepatic TRAF2 regulates glucose metabolism through enhancing glucagon responses', Diabetes, 61, pp. 566 - 573, http://dx.doi.org/10.2337/db11-0474

Journal articles | 2011

Tri P; Hampton H; Tomura M; Kanagawa O; Mackay C; Brink R; Chtanova T, 2011, 'Optical marking of migrating lymphocytes by two-photon photoconversion for single cell tracking and fate mapping', JOURNAL OF IMMUNOLOGY, 186, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209751703169&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Journal articles | 2011

2011, 'B cell priming for extrafollicular antibody responses requires Bcl-6 expression by T cells', Journal of Experimental Medicine, 208, pp. 1377 - 1388, http://dx.doi.org/10.1084/jem.20102065

Journal articles | 2011

2011, 'Deletion of cIAP1 and cIAP2 in murine B lymphocytes constitutively activates cell survival pathways and inactivates the germinal center response', Blood, 117, pp. 4041 - 4051, http://dx.doi.org/10.1182/blood-2010-10-312793

Journal articles | 2011

2011, 'EBI2 operates independently of but in co-operation with CXCR5 and CCR7 to direct B cell migration and organization in follicles and the germinal center', The Journal Of Immunology, 187, pp. 4621 - 4628, http://dx.doi.org/10.4049/jimmunol.1101542

Journal articles | 2011

2011, 'Impaired B cell development in the absence of Kruppel-like Factor 3.', Journal of Immunology, 187, pp. 5032 - 5042, http://dx.doi.org/10.4049/jimmunol.1101450

Journal articles | 2011

2011, 'Interaction of human, rat, and mouse immunoglobulin A (IgA) with staphylococcal superantigen-like 7 (SSL7) decoy protein and leukocyte IgA receptor', The Journal of Biological Chemistry, 286, pp. 33118 - 33124, http://dx.doi.org/10.1074/jbc.M111.272252

Journal articles | 2011

2011, 'New friends for bone marrow plasma cells', Nature Immunology, 12, pp. 115 - 117, http://dx.doi.org/10.1038/ni0211-115

Journal articles | 2011

2011, 'Regulation of T follicular helper cell formation and function by antigen presenting cells', Current Opinion in Immunology, 23, pp. 111 - 118, http://dx.doi.org/10.1016/j.coi.2010.10.007

Journal articles | 2010

Randall KL; Lambe T; Johnson A; Treanor B; Kucharska E; Domaschenz H; Whittle B; Tze LE; Enders A; Crockford TL; Bouriez-Jones T; Alston D; Cyster JG; Lenardo MJ; MacKay F; Deenick EK; Tangye SG; Chan TD; Camidge T; Brink R; Vinuesa CG; Batista FD; Cornall RJ; Goodnow CC, 2010, 'Erratum: Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production (Nature Immunology (2009) 10 (1283-1291))', Nature Immunology, 11, pp. 644, http://dx.doi.org/10.1038/ni0710-644a

Journal articles | 2010

2010, 'Control systems and decision making for antibody production', Nature Immunology, 11, pp. 681 - 688, http://dx.doi.org/10.1038/ni.1900

Journal articles | 2010

2010, 'High-affinity B cell receptor ligation by cognate antigen induces cytokine-independent isotype switching', Journal of Immunology, 184, pp. 6592 - 6599, http://dx.doi.org/10.4049/jimmunol.0903437

Journal articles | 2010

2010, 'Regulation of TNFRSF and innate immune signalling complexes by TRAFs and cIAPs', Cell death and differentiation, 7, pp. 35 - 45, http://dx.doi.org/10.1038/cdd.2009.114

Journal articles | 2010

2010, 'Sap is necessary for mediating antigen-specific effector functions of CD4+ AND CD8+ T cells', Pathology, 42, pp. S45 - S45, http://dx.doi.org/10.1097/01268031-201042001-00085

Journal articles | 2009

Goodnow CC; Crosbie J; Adelstein S; Lavoie TB; Smith-Gill SJ; Brink RA; Pritchard-Briscoe H; Wotherspoon JS; Loblay RH; Raphael K; Trent RJ; Basten A, 2009, 'Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice.', Journal of immunology (Baltimore, Md. : 1950), 183, pp. 5442 - 5448

Journal articles | 2009

2009, 'Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice (Reprinted from Nature, vol 334, pg 676-682, 1988)', JOURNAL OF IMMUNOLOGY, 183, pp. 5442 - 5448, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000271488500004&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Journal articles | 2009

2009, 'Antigen affinity controls rapid T-dependent antibody production by driving the expansion rather than the differentiation or extrafollicular migration of early plasmablasts', Journal of Immunology, 183, pp. 3139 - 3149, http://dx.doi.org/10.4049/jimmunol.0901690

Journal articles | 2009

2009, 'Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production', Nature Immunology, 10, pp. 1283 - 1291, http://dx.doi.org/10.1038/ni.1820

Journal articles | 2009

2009, 'Follicular helper T cells are required for systemic autoimmunity', Journal of Experimental Medicine, 206, pp. 561 - 576, http://dx.doi.org/10.1084/jem.20081886

Journal articles | 2009

2009, 'Guidance of B Cells by the Orphan G Protein-Coupled Receptor EBI2 Shapes Humoral Immune Responses', Immunity, 31, pp. 259 - 269, http://dx.doi.org/10.1016/j.immuni.2009.06.016

Journal articles | 2009

2009, 'Increased CD4+Foxp3+ T cells in BAFF-transgenic mice suppress T cell effector responses', Journal of Immunology, 182, pp. 793 - 801, http://dx.doi.org/10.4049/jimmunol.182.2.793

Journal articles | 2009

2009, 'Roquin differentiates the specialized functions of duplicated T cell costimulatory receptor genes CD28 and ICOS', Immunity, 30, pp. 228 - 241, http://dx.doi.org/10.1016/j.immuni.2008.12.015

Journal articles | 2008

2008, 'TRAF2 and TRAF3 signal adapters act cooperatively to control the maturation and survival signals delivered to B cells by the BAFF receptor', Immunity, 28, pp. 391 - 401, http://dx.doi.org/10.1016/j.immuni.2008.01.009

Journal articles | 2008

2008, 'TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1-TRAF2 complex to sensitize tumor cells to TNF alpha', Journal of Cell Biology, 182, pp. 171 - 184, http://dx.doi.org/10.1083/jcb.200801010

Journal articles | 2008

2008, 'TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1–TRAF2 complex to sensitize tumor cells to TNFα', The Journal of Experimental Medicine, 205, pp. i18 - i18, http://dx.doi.org/10.1084/jem2058oia18

Journal articles | 2008

2008, 'Visualizing the effects of antigen affinity on T-dependent B-cell differentiation', Immunology and Cell Biology, 86, pp. 31 - 39, http://dx.doi.org/10.1038/sj.icb.7100143

Journal articles | 2007

2007, 'B cells and the BAFF/APRIL axis: fast-forward on autoimmunity and signaling', Current Opinion in Immunology, 19, pp. 327 - 336, http://dx.doi.org/10.1016/j.coi.2007.04.008

Journal articles | 2007

2007, 'Germinal-center B cells in the zone', Immunity, 26, pp. 552 - 554, http://dx.doi.org/10.1016/j.immuni.2007.05.002

Journal articles | 2007

2007, 'IAP antagonists target cIAP1 to induce TNF alpha- dependent apoptosis', Cell, 131, pp. 682 - 693, http://dx.doi.org/10.1016/j.cell.2007.10.037

Journal articles | 2006

Paus D; Tri GP; Chan TD; Gardam S; Basten A; Brink R, 2006, 'Antigen recognition strength regulates the choice between extrafollicular plasma cell and germinal center B cell differentiation', Journal of Experimental Medicine, 203, pp. 1081 - 1091, http://dx.doi.org/10.1084/jem.20060087

Journal articles | 2006

Phan TG; Paus D; Chan TD; Turner ML; Nutt SL; Basten A; Brink R, 2006, 'High affinity germinal center B cells are actively selected into the plasma cell compartment', Journal of Experimental Medicine, 203, pp. 2419 - 2424, http://dx.doi.org/10.1084/jem.20061254

Journal articles | 2006

2006, 'Regulation of B cell self-tolerance by BAFF', Seminars in Immunology, 18, pp. 276 - 283, http://dx.doi.org/10.1016/j.smim.2006.04.003

Journal articles | 2005

Grech AP; Gardam S; Chan T; Quinn R; Gonzales E; Basten A; Brink R, 2005, 'Tumor necrosis factor receptor 2 (TNFR2) signaling is negatively regulated by a novel, carboxyl-terminal TNFR-associated factor 2 (TRAF2)-binding site', Journal of Biological Chemistry, 280, pp. 31572 - 31581, http://dx.doi.org/10.1074/jbc.M504849200

Journal articles | 2005

Tri GP; Gardam S; Basten A; Brink R, 2005, 'Altered migration, recruitment, and somatic hypermutation in the early response of marginal zone B cells to T cell-dependent antigen', Journal of Immunology, 174, pp. 4567 - 4578, http://dx.doi.org/10.4049/jimmunol.174.8.4567

Journal articles | 2004

Avery DT; Kalled SL; Ellyard JI; Ambrose C; Bixler SA; Thien M; Brink R; Mackay F; Hodgkin PD; Tangye SG, 2004, 'Erratum: BAFF selectively enhances the survival of plasmablasts generated from human memory B cells (Journal of Clinical Investigation (2003) 112 (286-297) doi:10.1172/JCI200318025)', Journal of Clinical Investigation, 113, pp. 1069, http://dx.doi.org/10.1172/JCI200318025C

Journal articles | 2004

Grech AP; Amesbury M; Chan T; Gardam S; Basten A; Brink R, 2004, 'TRAF2 differentially regulates the canonical and noncanonical pathways of NF-κB activation in mature B cells', Immunity, 21, pp. 629 - 642, http://dx.doi.org/10.1016/j.immuni.2004.09.011

Journal articles | 2004

2004, 'BAFF selectively enhances the survival of plasmablasts generated from human memory B cells', Journal of Clinical Investigation, 113, pp. 1069 - 1069, http://dx.doi.org/10.1172/jci18025e1

Journal articles | 2003

Cook AJ L; Oganesian L; Harumal P; Basten A; Brink R; Jolly CJ, 2003, 'Reduced Switching in SCID B Cells Is Associated with Altered Somatic Mutation of Recombined S Regions', Journal of Immunology, 171, pp. 6556 - 6564, http://dx.doi.org/10.4049/jimmunol.171.12.6556

Journal articles | 2003

Phan TG; Amesbury M; Gardam S; Crosbie J; Hasbold J; Hodgkin PD; Basten A; Brink R, 2003, 'B cell receptor-independent stimuli trigger immunoglobulin (Ig) class switch recombination and production of IgG autoantibodies by anergic self-reactive B cells', Journal of Experimental Medicine, 197, pp. 845 - 860, http://dx.doi.org/10.1084/jem.20022144

Journal articles | 2003

2003, 'BAFF selectively enhances the survival of plasmablasts generated from human memory B cells', Journal of Clinical Investigation, 112, pp. 286 - 297, http://dx.doi.org/10.1172/JCI18025

Journal articles | 2000

Grech A; Quinn R; Srinivasan D; Badoux X; Brink R, 2000, 'Complete structural characterisation of the mammalian and Drosophila TRAF genes: Implications for TRAF evolution and the role of RING finger splice variants', Molecular Immunology, 37, pp. 721 - 734, http://dx.doi.org/10.1016/S0161-5890(00)00098-5

Journal articles | 1998

Brink R; Lodish HF, 1998, 'Tumor necrosis factor receptor (TNFR)-associated factor 2A (TRAF2A), a TRAF2 splice variant with an extended RING finger domain that inhibits TNFR2- mediated NF-κB activation', Journal of Biological Chemistry, 273, pp. 4129 - 4134, http://dx.doi.org/10.1074/jbc.273.7.4129

Journal articles | 1995

Brink R; Goodnow CC; Basten A, 1995, 'IgD expression on B cells is more efficient than IgM but both receptors are functionally equivalent in up‐regulation CD80/CD86 co‐stimulatory molecules', European Journal of Immunology, 25, pp. 1980 - 1984, http://dx.doi.org/10.1002/eji.1830250727

Journal articles | 1994

Brink R; Fulcher DA; Goodnow CC; Basten A, 1994, 'Differential regulation of early and late stages of B lymphocyte development by the μ and δ membrane heavy chains of Ig', International Immunology, 6, pp. 1905 - 1916, http://dx.doi.org/10.1093/intimm/6.12.1905

Journal articles | 1994

Eris JM; Basten A; Brink R; Doherty K; Kehry MR; Hodgkin PD, 1994, 'Anergic self-reactive B cells present self antigen and respond normally to CD40-dependent T-cell signals but are defective in antigen-receptor-mediated functions', Proceedings of the National Academy of Sciences of the United States of America, 91, pp. 4392 - 4396, http://dx.doi.org/10.1073/pnas.91.10.4392

Journal articles | 1992

Brink R; Goodnow CC; Crosbie J; Adams E; Eris J; Mason DY; Hartley SB; Basten A, 1992, 'Immunoglobulin M and D Antigen Receptors are Both Capable of Mediating B Lymphocyte Activation, Deletion, or Anergy After Interaction with Specific Antigen', Journal of Experimental Medicine, 176, pp. 991 - 1005, http://dx.doi.org/10.1084/jem.176.4.991

Journal articles | 1991

Basten A; Brink R; Peake P; Adams E; Crosbie J; Hartley S; Goodnow CC, 1991, 'Self Tolerance in the B‐Cell Repertoire', Immunological Reviews, 122, pp. 5 - 19, http://dx.doi.org/10.1111/j.1600-065X.1991.tb00593.x

Journal articles | 1991

Basten A; Brink R; Peake P; Adams E; Crosbie J; Hartley S; Goodnow CC, 1991, 'Self tolerance in the B-cell repertoire', Immunological Reviews

Journal articles | 1991

Goodnow CC; Brink R; Adams E, 1991, 'Breakdown of self-tolerance in anergic B lymphocytes', Nature, 352, pp. 532 - 536, http://dx.doi.org/10.1038/352532a0

Journal articles | 1991

Hartley SB; Crosbie J; Brink R; Kantor AB; Basten A; Goodnow CC, 1991, 'Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens', Nature, 353, pp. 765 - 769, http://dx.doi.org/10.1038/353765a0

Journal articles | 1989

Goodnow CC; Crosbie J; Jorgensen H; Brink RA; Basten A, 1989, 'Induction of self-tolerance in mature peripheral B lymphocytes', Nature, 342, pp. 385 - 391, http://dx.doi.org/10.1038/342385a0

Journal articles | 1989

1989, 'CLONAL SILENCING OF SELF-REACTIVE LYMPHOCYTES-B IN A TRANSGENIC MOUSE MODEL', COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 54, pp. 907 - 920, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1989JX74600035&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Journal articles | 1988

Goodnow CC; Crosbie J; Adelstein S; Lavoie TB; Smith-Gill SJ; Brink RA; Pritchard-Briscoe H; Wotherspoon JS; Loblay RH; Raphael K; Trent RJ; Basten A, 1988, 'Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice', Nature, 334, pp. 676 - 682, http://dx.doi.org/10.1038/334676a0
Preprints | 2022

2022, STAT3gain-of-function mutations connect leukemia with autoimmune disease by pathological dysregulation of NKG2D^hiCD8 killer T cells, , http://dx.doi.org/10.1101/2022.02.11.480027

Preprints | 2022

2022, Environmental and genetic disease modifiers of haploinsufficiency of A20, , http://dx.doi.org/10.1101/2022.03.19.485004

Preprints | 2022

2022, IL-21 has a critical role in establishing germinal centers by amplifying early B cell proliferation, , http://dx.doi.org/10.1101/2022.01.21.476732

Preprints | 2022

2022, Increased core body temperature exacerbates defective protein prenylation in mouse avatars of mevalonate kinase deficiency, , http://dx.doi.org/10.1101/2022.02.28.480959

Conference Papers | 2021

2021, 'T cell dysfunction in Activated P13K delta Syndrome explained by cell intrinsic and extrinsic components', in JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000713665800408&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Preprints | 2021

2021, Overactive STAT3 drives accumulation of disease-associated CD21^lowB cells, , http://dx.doi.org/10.1101/2021.12.20.473595

Conference Papers | 2020

2020, 'The effects of germline STAT3-activating mutations from autoimmunity and lymphoid malignancy on mouse and human T cells', in JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, HI, Honolulu, presented at Annual Meeting of the American-Association-of-Immunologists - Immunology 2020, HI, Honolulu, 08 May 2020 - 12 May 2020, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000589972401141&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Preprints | 2020

2020, Loss-of-function of Fbxo10, encoding a post-translational regulator of BCL2 in lymphomas, has no discernible effect on BCL2 or B lymphocyte accumulation in mice, , http://dx.doi.org/10.1101/2020.08.05.237545

Preprints | 2020

2020, Osteocyte Transcriptome Mapping Identifies a Molecular Landscape Controlling Skeletal Homeostasis and Susceptibility to Skeletal Disease, , http://dx.doi.org/10.1101/2020.04.20.051409

Conference Abstracts | 2019

2019, 'The effects of germline STAT3-activating mutations from autoimmunity and lymphoid malignancy on mouse and human T cell development and function', in EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY, PEOPLES R CHINA, Beijing, Vol. 49, pp. 901 - 901, presented at 17th International Congress of Immunology of the International-Union-of-Immunological-Societies (IUIS), PEOPLES R CHINA, Beijing, 19 October 2019 - 23 October 2019, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000490026902546&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts | 2018

2018, 'Exploring the Germ-Line Contribution to Exceptional Response to PD-1/PD-L1 Inhibition in Patients with NSCLC by Whole Genome Sequencing', in JOURNAL OF THORACIC ONCOLOGY, ELSEVIER SCIENCE INC, Vol. 13, pp. S529 - S529, http://dx.doi.org/10.1016/j.jtho.2018.08.726

Conference Papers | 2018

2018, 'Exploring the germ-line contribution to exceptional response to PD-1/PD-L1 inhibition in patients with metastatic non-small-cell lung cancer by whole genome sequencing', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, IL, Chicago, presented at Annual Meeting of the American-Association-for-Cancer-Research (AACR), IL, Chicago, 14 April 2018 - 18 April 2018, http://dx.doi.org/10.1158/1538-7445.AM2018-LB-121

Conference Abstracts | 2017

Burnett D; Schofield P; Langley D; Brink R; Christ D; Goodnow CC, 2017, 'Somatic Hypermutation Serves two independent Functions: Antibody Maturation Away From Binding Self and Towards Binding Foreign', in EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY, GERMANY, Erlangen, Vol. 47, pp. 3 - 3, presented at 47th Annual Meeting of the German-Society-for-Immunology (DGFI), GERMANY, Erlangen, 12 September 2017 - 15 September 2017, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000418423100003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts | 2017

McDonald M; Ng PY; Butt D; Pathmanandavel K; Biro M; Terry R; Khoo WH; Mohanty S; Simic M; Chai R; Quinn J; Pettitt J; Abi-Hanna D; Jain R; Weninger W; Baldock P; Rogers M; Brink R; Pavlos N; Croucher P; Phan T, 2017, 'Intravital imaging of osteoclasts in vivo reveals cellular recycling as a novel cell fate mechanism.', in JOURNAL OF BONE AND MINERAL RESEARCH, WILEY, CO, Denver, Vol. 32, pp. S37 - S37, presented at Annual Meeting of the American-Society-for-Bone-and-Mineral-Research (ASBMR), CO, Denver, 08 September 2017 - 11 September 2017, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000418869200110&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts | 2017

Sundling C; Butt D; Suan D; Lau A; Brink R, 2017, 'Counter-selection versus switching in the demise of IgM(+) germinal center B cells', in SCANDINAVIAN JOURNAL OF IMMUNOLOGY, WILEY, SWEDEN, Stockholm, Vol. 86, pp. 250 - 250, presented at 44th Annual Meeting of the Scandinavian-Society-for-Immunology (SSI), SWEDEN, Stockholm, 17 October 2017 - 20 October 2017, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000411865200010&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts | 2017

Torcellan T; Hampton HR; Bailey J; Tomura M; Brink R; Chtanova T, 2017, 'Using in vivo photolabeling to uncover the fate of tumour-infiltrating T cell migration in tumour immunity', in EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY, GERMANY, Erlangen, Vol. 47, pp. 64 - 64, presented at 47th Annual Meeting of the German-Society-for-Immunology (DGFI), GERMANY, Erlangen, 12 September 2017 - 15 September 2017, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000418423100064&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts | 2017

2017, 'Identification of anabolic bone genes using whole genome sequencing in high bone mass families.', in JOURNAL OF BONE AND MINERAL RESEARCH, WILEY, WILEY 111 RIVER ST, HOBOKEN 07030-5774, NJ USA, Vol. 32, pp. S71 - S71, presented at Annual Meeting of the American-Society-for-Bone-and-Mineral-Research (ASBMR), WILEY 111 RIVER ST, HOBOKEN 07030-5774, NJ USA, 08 September 2017 - 11 September 2017, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000418869201011&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Conference Abstracts | 2016

Burnett D; Schofield P; Christ D; Brink R; Goodnow C, 2016, 'Somatic hypermutation serves two independent functions: antibody maturation away from binding self and towards binding foreign', in EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY-BLACKWELL, AUSTRALIA, Melbourne, Vol. 46, pp. 803 - 804, presented at International Congress of Immunology (ICI), AUSTRALIA, Melbourne, 21 August 2016 - 26 August 2016, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000383610402005&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts | 2016

Butt D; Chan T; Bourne K; Hermes J; Strasser A; Tangye S; Phan T; Rao VK; Brink R, 2016, 'Rogue germinal center B cells: unconventional lymphocytes released by FAS inactivation that drive IgE and autoantibody production', in EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY-BLACKWELL, AUSTRALIA, Melbourne, Vol. 46, pp. 25 - 26, presented at International Congress of Immunology (ICI), AUSTRALIA, Melbourne, 21 August 2016 - 26 August 2016, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000383610400052&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts | 2016

Goodnow C; Reed J; Burnett D; Brink R; Christ D; Schofield P; Perotti S; Enders A; Ziegler J; Wainstein B; Roscioli T; Gray P, 2016, 'Redemption or Revolt of Forbidden Clones: Mutations, Autoantibodies and CTLA4-Ig Therapy', in EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY-BLACKWELL, AUSTRALIA, Melbourne, Vol. 46, pp. 3 - 3, presented at International Congress of Immunology (ICI), AUSTRALIA, Melbourne, 21 August 2016 - 26 August 2016, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000383610400007&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts | 2016

Kane A; Lau A; Brink R; Tangye S; Deenick E, 2016, 'STAT3 is a critical B-cell intrinsic regulator of functional antibody responses and IgE production', in EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY-BLACKWELL, AUSTRALIA, Melbourne, Vol. 46, pp. 849 - 849, presented at International Congress of Immunology (ICI), AUSTRALIA, Melbourne, 21 August 2016 - 26 August 2016, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000383610402097&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts | 2016

Kara E; Bastow C; Mckenzie D; Gregor C; Fenix K; Norton T; Zotos D; Rodda L; Vinuesa C; Tarlinton D; Brink R; Cyster J; Comerford I; Mccoll S, 2016, 'The atypical chemokine receptor ACKR4 shapes early antibody responses', in EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY-BLACKWELL, AUSTRALIA, Melbourne, Vol. 46, pp. 1261 - 1262, presented at International Congress of Immunology (ICI), AUSTRALIA, Melbourne, 21 August 2016 - 26 August 2016, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000391563600050&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts | 2016

Lau A; Chan T; Brink R, 2016, 'Control of germinal center and early memory B cell homeostasis by BAFFR', in EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY-BLACKWELL, AUSTRALIA, Melbourne, Vol. 46, pp. 1131 - 1131, presented at International Congress of Immunology (ICI), AUSTRALIA, Melbourne, 21 August 2016 - 26 August 2016, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000383610402670&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts | 2016

Lim EX; Figgett WA; Brink R; Mackay F, 2016, 'Loss of TACI expression allows self-reactive MZ B cells to escape deletion but not anergy', in EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY-BLACKWELL, AUSTRALIA, Melbourne, Vol. 46, pp. 716 - 716, presented at International Congress of Immunology (ICI), AUSTRALIA, Melbourne, 21 August 2016 - 26 August 2016, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000383610401633&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts | 2016

McDonald M; Butt D; Terry R; Quinn J; Rogers M; Brink R; Croucher P; Phan T, 2016, 'Real-time intravital longitudinal imaging of osteoclast formation, function and fate during bone remodeling', in EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY-BLACKWELL, AUSTRALIA, Melbourne, Vol. 46, pp. 270 - 270, presented at International Congress of Immunology (ICI), AUSTRALIA, Melbourne, 21 August 2016 - 26 August 2016, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000383610400545&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts | 2016

Moran I; Nguyen A; Brink R; Phan TG, 2016, 'Where and how memory cells are reactivated in the secondary antibody response in the lymph node', in EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY-BLACKWELL, AUSTRALIA, Melbourne, Vol. 46, pp. 823 - 823, presented at International Congress of Immunology (ICI), AUSTRALIA, Melbourne, 21 August 2016 - 26 August 2016, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000383610402045&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts | 2016

Nguyen A; Moran I; Tanaka M; Tangye S; Brink R; Phan T, 2016, 'Dynamic changes in gene regulatory networks control subcapsular sinus macrophage fate and function', in EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY-BLACKWELL, AUSTRALIA, Melbourne, Vol. 46, pp. 430 - 430, presented at International Congress of Immunology (ICI), AUSTRALIA, Melbourne, 21 August 2016 - 26 August 2016, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000383610401057&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts | 2016

Shklovskaya E; Terry A; Guy T; Bolton H; Brink R; Fazekas de St Groth B, 2016, 'Interactions between CD4 T cells, regulatory T cells and B cells shape the immune response to tumours', in EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY, AUSTRALIA, Melbourne, Vol. 46, pp. 862 - 863, presented at International Congress of Immunology (ICI), AUSTRALIA, Melbourne, 21 August 2016 - 26 August 2016, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000383610402126&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts | 2016

Suan D; Krautler N; Butt D; Bourne K; Hermes J; Schofield P; Jackson J; Phan TG; Christ D; Brink R, 2016, 'Antigen-linked rather than T-FH cell-derived signals select high affinity germinal centre B cells for plasma cell differentiation', in EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY-BLACKWELL, AUSTRALIA, Melbourne, Vol. 46, pp. 296 - 296, presented at International Congress of Immunology (ICI), AUSTRALIA, Melbourne, 21 August 2016 - 26 August 2016, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000383610400596&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts | 2016

Suan D; Krautler N; Maag J; Butt D; Wood K; Hermes J; Priestley D; Statham A; Elliott M; Marcel D; Basten A; Tangye S; Brink R, 2016, 'Memory B cells develop from low-affinity clones in the germinal center light zone and are identified by CCR6 expression in mice and humans', in EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY-BLACKWELL, AUSTRALIA, Melbourne, Vol. 46, pp. 1132 - 1133, presented at International Congress of Immunology (ICI), AUSTRALIA, Melbourne, 21 August 2016 - 26 August 2016, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000383610402674&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts | 2016

Torcellan T; Hampton HR; Bailey J; Tomura M; Brink R; Chtanova T, 2016, 'Tumour-infiltrating T cells leave tumours to provide effector functions in draining lymph nodes', in EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY-BLACKWELL, AUSTRALIA, Melbourne, Vol. 46, pp. 1006 - 1007, presented at International Congress of Immunology (ICI), AUSTRALIA, Melbourne, 21 August 2016 - 26 August 2016, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000383610402420&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts | 2016

Vijayan D; Redzwan MN; Avery D; Wirasinha R; Brink R; Walters G; Adelstein S; Kobayashi M; Gray P; Elliott M; King C; Vinuesa C; Ghilardi N; Ma C; Tangye S; Batten M, 2016, 'IL-27 directly influences germinal center B cell development via STAT1', in EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY-BLACKWELL, AUSTRALIA, Melbourne, Vol. 46, pp. 1082 - 1082, presented at International Congress of Immunology (ICI), AUSTRALIA, Melbourne, 21 August 2016 - 26 August 2016, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000383610402571&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts | 2015

O'Reilly L; Cantley J; Turner V; Brink R; Schmitz-Peiffer C; Biden TJ, 2015, 'Deletion of PKC epsilon in islet-associated macrophages improves beta cell function', in DIABETOLOGIA, SPRINGER, SWEDEN, Stockholm, Vol. 58, pp. S219 - S219, presented at 51st Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), SWEDEN, Stockholm, 14 September 2015 - 18 September 2015, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000359820901131&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Papers | 2014

Espeli M; Sowerby JM; Linterman MA; Brink R; Smith KG C, 2014, 'The Inhibitory Receptor FcgammaRIIb Differentially Regulates Central and GC Tolerance', in SCANDINAVIAN JOURNAL OF IMMUNOLOGY, WILEY-BLACKWELL, SWEDEN, Uddevalla, pp. 216 - 216, presented at 18th Germinal Centre Conference, SWEDEN, Uddevalla, 11 September 2014 - 14 September 2014, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000340899200023&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Papers | 2014

Motallebzadeh R; Rehakova S; Bolton E; Linterman M; Brink R; Bradley JA; Pettigrew G, 2014, 'The functional role of tertiary lymphoid organs in allografts', in BRITISH JOURNAL OF SURGERY, WILEY-BLACKWELL, ENGLAND, Univ Cambridge, Robinson Coll, Cambridge, pp. 40 - 40, presented at Annual Meeting of the Society-of-Academic-and-Research-Surgery, ENGLAND, Univ Cambridge, Robinson Coll, Cambridge, 08 January 2014 - 09 January 2014, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000334502500130&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Papers | 2014

Villanueva J; Walters S; Saito M; Marino E; Malle E; Zammit N; Brink R; Alexander S; Grey S, 2014, 'Loss of TRAF2 Impairs Alloreactive CD4(+) T Cells and Maintains Tregs to Favour Islet Allograft Survival Without Exogenous Immunosuppression', in AMERICAN JOURNAL OF TRANSPLANTATION, WILEY-BLACKWELL, CA, San Francisco, pp. 40 - 40, presented at World Transplant Congress, CA, San Francisco, 26 July 2014 - 31 July 2014, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000338033300134&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Papers | 2014

Villanueva J; Walters S; Saito M; Marino E; Malle E; Zammit N; Brink R; Alexander S; Grey S, 2014, 'Loss of TRAF2 Impairs Alloreactive CD4(+) T Cells and Maintains Tregs to Favour Islet Allograft Survival Without Exogenous Immunosuppression.', in TRANSPLANTATION, LIPPINCOTT WILLIAMS & WILKINS, CA, San Francisco, pp. 40 - 40, presented at World Transplant Congress, CA, San Francisco, 26 July 2014 - 31 July 2014, http://dx.doi.org/10.1097/00007890-201407151-00133

Conference Papers | 2013

Malle EK; Walters SN; Zammit NW; Cantley J; Brink R; Grey ST, 2013, 'Intra-islet inflammation in type 2 diabetes: evidence that the E3 ligase TRAF2 is a key protective factor in beta cells', in DIABETOLOGIA, SPRINGER, SPAIN, Barcelona, pp. S54 - S54, presented at 49th Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), SPAIN, Barcelona, 23 September 2013 - 27 September 2013, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000329196900117&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Papers | 2013

Redzwan NM; Vijayan D; Ma C; Tangye S; Brink R; Vinuesa C; Batten M, 2013, 'IL-27 signals to both B and T cells support germinal center function and the development of GC-driven lupus', in CYTOKINE, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, CA, San Francisco, pp. 292 - 292, presented at Annual Joint Conference of the International-Cytokine-Society and the International-Society-for-Interferon-and-Cytokine-Research, CA, San Francisco, 29 September 2013 - 03 October 2013, http://dx.doi.org/10.1016/j.cyto.2013.06.210

Conference Papers | 2013

Villanueva J; Walters SN; Marino E; Saito M; Alexander S; Brink R; Grey ST, 2013, 'Permanent Survival of Islet Allografts and Delayed Rejection of Heart and Skin Allografts Without Exogenous Immunosuppression by Targeting TNF-Receptor Associated Factor 2', in TRANSPLANTATION, LIPPINCOTT WILLIAMS & WILKINS, CA, Monterey, pp. S62 - S62, presented at 14th World Congress of the International-Pancreas-and-Islet-Transplant-Association (IPITA), CA, Monterey, 24 September 2013 - 27 September 2013, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000330443500112&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Papers | 2011

Plummer PN; Taft R; Mattick J; McMillan N; Swarbrick A; Brink R; Mittal V; Mellick AS, 2011, 'MICRORNAS AS TOOLS TO TARGET BONE MARROW MEDIATED TUMOUR ANGIOGENESIS', in JOURNAL OF GENE MEDICINE, WILEY, AUSTRALIA, Univ Melbourne, Bio21 Inst, Parkville, pp. 430 - 430, presented at 7th Biennial Meeting of the Australasian-Gene-Therapy-Society, AUSTRALIA, Univ Melbourne, Bio21 Inst, Parkville, 04 May 2011 - 06 May 2011, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000297950900039&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Papers | 2011

Plummer PN; Taft R; Mattick J; McMillan N; Swarbrick A; Brink R; Mittal V; Mellick AS, 2011, 'MICRORNAS AS TOOLS TO TARGET BONE MARROW MEDIATED TUMOUR ANGIOGENESIS', in JOURNAL OF GENE MEDICINE, WILEY, AUSTRALIA, Univ Melbourne, Bio21 Inst, Parkville, pp. 443 - 443, presented at 7th Biennial Meeting of the Australasian-Gene-Therapy-Society, AUSTRALIA, Univ Melbourne, Bio21 Inst, Parkville, 04 May 2011 - 06 May 2011, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000297950900061&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Papers | 2010

Randall K; Lambe T; Johnson A; Kucharska E; Vinuesa C; Treanor B; Batista F; Chan T; Camidge T; Brink R; Cornall R; Goodnow C, 2010, 'Immunodeficiency and Abnormal B Cell Synapse Formation due to DOCK8 Mutations in Mice', in CLINICAL IMMUNOLOGY, ACADEMIC PRESS INC ELSEVIER SCIENCE, MA, Boston, pp. S17 - S17, presented at 10th Annual Meeting of the Federation-of-Clinical-Immunology-Societies, MA, Boston, 24 June 2010 - 27 June 2010, http://dx.doi.org/10.1016/j.clim.2010.03.055

Conference Papers | 2005

Phan TG; Paus D; Chan TD; Gardam S; Amesbury M; Crosbie J; Basten A; Brink R, 2005, 'Visuallising B cell responses to protein antigens of varying affinity in vivo', in TISSUE ANTIGENS, BLACKWELL PUBLISHING, AUSTRALIA, Melbourne, pp. 511 - 512, presented at 35th Annual SCientific Meeting of the Australasian-Society-for-Immunology/14th International HLA and Immunogenetics Workshops, AUSTRALIA, Melbourne, 29 November 2005 - 02 December 2005, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000233542700464&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Papers | 1989

Goodnow CC; Crosbie J; Adelstein S; Lavoie TB; Smith-Gill SJ; Mason DY; Jorgensen H; Brink RA; Pritchard-Briscoe H; Loughnan M; Loblay RH; Trent RJ; Basten A, 1989, 'Clonal silencing of self-reactive B lymphocytes in a transgenic mouse model', in Cold Spring Harbor Symposia on Quantitative Biology, pp. 907 - 920, http://dx.doi.org/10.1101/sqb.1989.054.01.106

Conference Papers | 1989

1989, 'SELF-TOLERANCE IN B-CELLS FROM DIFFERENT LINES OF LYSOZYME DOUBLE-TRANSGENIC MICE', in MELCHERS F (ed.), PROGRESS IN IMMUNOLOGY, VOL 7, SPRINGER-VERLAG BERLIN, FED REP GER, BERLIN, pp. 377 - 384, presented at 7TH INTERNATIONAL CONGRESS OF IMMUNOLOGY, FED REP GER, BERLIN, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1989BP83Z00049&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Papers | 1988

1988, 'IMMUNOLOGICAL-TOLERANCE IN LYSOZYME ANTILYSOZYME TRANSGENIC MICE', in SMITHGILL SJ; SERCARZ EE (ed.), IMMUNE RESPONSE TO STRUCTURALLY DEFINED PROTEINS : THE LYSOZYME MODEL, ADENINE PRESS, MD, MARY WOODARD LASKER CTR HLTH RES & EDUC, BETHESDA, pp. 389 - 402, presented at WORKSHOP ON THE IMMUNOLOGY OF LYSOZYME, MD, MARY WOODARD LASKER CTR HLTH RES & EDUC, BETHESDA, 13 June 1988 - 15 June 1988, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1989BR20A00037&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Preprints |

Overactive STAT3 Drives Accumulation of Disease-Associated CD21 <sup>low</sup> B Cells, , http://dx.doi.org/10.2139/ssrn.3996405

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Professor Robert Brink