Professor Robert Brink

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Book Chapters | 2015

Brink R; Paus D; Bourne K; Hermes JR; Gardam S; Phan TG; Chan TD, 2015, 'The SWHEL system for high-resolution analysis of in vivo antigen-specific T-dependent B cell responses', in T Follicular Helper Cells: Methods and Protocols, pp. 103 - 123, http://dx.doi.org/10.1007/978-1-4939-2498-1_9

Book Chapters | 2011

Brink R, 2011, 'B Lymphocytes', in Immunology and Immunopathology, Oxford UK, http://www.eolss.net/

Book Chapters | 2010

Brink R; Gardam S, 2010, 'Regulation of B-cell self-tolerance by BAFF and the molecular basis of its action', in Cancro MP (ed.), BLys Ligands and Receptors, Humana Press, pp. 43 - 63, http://www.springer.com/biomed/immunology/book/978-1-60327-012-0

Book Chapters | 2006

BASTEN A; BRINK R, 2006, 'CHAPTER 13 Tolerance and Autoimmunity: B Cells', in The Autoimmune Diseases, Elsevier, pp. 167 - 177, http://dx.doi.org/10.1016/b978-012595961-2/50016-0

Book Chapters | 2006

Basten A; Brink R, 2006, 'Tolerance and Autoimmunity: B Cells', in The Autoimmune Diseases, Fourth Edition, pp. 167 - 177, http://dx.doi.org/10.1016/B978-012595961-2/50016-0
Journal articles | 2025

Dhenni R; Hoppé AC; Reynaldi A; Kyaw W; Handoko NT; Grootveld AK; Keith YH; Bhattacharyya ND; Ahel HI; Telfser AJ; McCorkindale AN; Yazar S; Bui CHT; Smith JT; Khoo WH; Boyd M; Obeid S; Milner B; Starr M; Brilot F; Milogiannakis V; Akerman A; Aggarwal A; Davenport MP; Deenick EK; Chaffer CL; Croucher PI; Brink R; Goldstein LD; Cromer D; Turville SG; Kelleher AD; Venturi V; Munier CML; Phan TG, 2025, 'Macrophages direct location-dependent recall of B cell memory to vaccination', Cell, pp. S0092-8674(25)00407-6, http://dx.doi.org/10.1016/j.cell.2025.04.005

Journal articles | 2025

Young C; Singh M; Jackson KJL; Field MA; Peters TJ; Angioletti-Uberti S; Frenkel D; Ravishankar S; Gupta M; Wang JJ; Agapiou D; Faulks ML; Al-Eryani G; Luciani F; Gordon TP; Reed JH; Danta M; Carr A; Kelleher AD; Dore GJ; Matthews G; Brink R; Bull RA; Suan D; Goodnow CC, 2025, 'A triad of somatic mutagenesis converges in self-reactive B cells to cause a virus-induced autoimmune disease', Immunity, 58, pp. 412 - 430.e10, http://dx.doi.org/10.1016/j.immuni.2024.12.011

Journal articles | 2024

Dvorscek AR; McKenzie CI; Stäheli VC; Ding Z; White J; Fabb SA; Lim L; O'Donnell K; Pitt C; Christ D; Hill DL; Pouton CW; Burnett DL; Brink R; Robinson MJ; Tarlinton DM; Quast I, 2024, 'Conversion of vaccines from low to high immunogenicity by antibodies with epitope complementarity', Immunity, 57, pp. 2433 - 2452.e7, http://dx.doi.org/10.1016/j.immuni.2024.08.017

Journal articles | 2024

Ham H; Jing H; Lamborn IT; Kober MM; Koval A; Berchiche YA; Anderson DE; Druey KM; Mandl JN; Isidor B; Ferreira CR; Freeman AF; Ganesan S; Karsak M; Mustillo PJ; Teo J; Zolkipli-Cunningham Z; Chatron N; Lecoquierre F; Oler AJ; Schmid JP; Kuhns DB; Xu X; Hauck F; Al-Herz W; Wagner M; Terhal PA; Muurinen M; Barlogis V; Cruz P; Danielson J; Stewart H; Loid P; Rading S; Keren B; Pfundt R; Zarember KA; Vill K; Potocki L; Olivier KN; Lesca G; Faivre L; Wong M; Puel A; Chou J; Tusseau M; Moutsopoulos NM; Matthews HF; Simons C; Taft RJ; Soldatos A; Masle-Farquhar E; Pittaluga S; Brink R; Fink DL; Kong HH; Kabat J; Kim WS; Bierhals T; Meguro K; Hsu AP; Gu J; Stoddard J; Banos-Pinero B; Slack M; Trivellin G; Mazel B; Soomann M; Li S; Watts VJ; Stratakis CA; Rodriguez-Quevedo MF; Bruel AL; Lipsanen-Nyman M; Saultier P; Jain R; Lehalle D; Torres D; Sullivan KE; Barbarot S; Neu A; Duffourd Y; Similuk M; McWalter K; Blanc P; Bézieau S; Jin T; Geha RS; Casanova JL; Makitie OM; Kubisch C; Edery P; Christodoulou J; Germain RN; Goodnow CC; Sakmar TP; Billadeau DD; Küry S; Katanaev VL; Zhang Y, 2024, 'Germline mutations in a G protein identify signaling cross-talk in T cells', Science (New York, N.Y.), 385, pp. eadd8947, http://dx.doi.org/10.1126/science.add8947

Journal articles | 2024

Katerelos M; Gleich K; Harley G; Loh K; Oakhill JS; Kemp BE; de Souza DP; Narayana VK; Coughlan MT; Laskowski A; Ling NXY; Murray-Segal L; Brink R; Lee M; Power DA; Mount PF, 2024, 'The AMPK activator ATX-304 alters cellular metabolism to protect against cisplatin-induced acute kidney injury', Biomedicine and Pharmacotherapy, 175, http://dx.doi.org/10.1016/j.biopha.2024.116730

Journal articles | 2024

Pan Z; Sharkway RE; Bayoumi A; Metwally M; Gloss BS; Brink R; Lu DB; Liddle C; Alqahtani SA; Yu J; O’Connell PJ; George J; Eslam M, 2024, 'Inhibition of MERTK reduces organ fibrosis in mouse models of fibrotic disease', Science Translational Medicine, 16, http://dx.doi.org/10.1126/scitranslmed.adj0133

Journal articles | 2023

Barnet MB; Masle-Farquhar E; Russell A; Burnett DL; Jackson KJL; Brink R; Heller G; Yang C; Prokopec S; Behren A; Davis ID; Peters GD; Boyer MJ; John T; Nagrial A; Gao B; Blinman P; Kao SC-H; Cebon JS; Goodnow CC, 2023, 'Association of common inherited NOD2 mutations with exceptional response to immune checkpoint inhibitors.', Journal of Clinical Oncology, 41, pp. 2514 - 2514, http://dx.doi.org/10.1200/jco.2023.41.16_suppl.2514

Journal articles | 2023

Ceglia S; Berthelette A; Howley K; Li Y; Mortzfeld B; Bhattarai SK; Yiew NKH; Xu Y; Brink R; Cyster JG; Hooper LV; Randolph GJ; Bucci V; Reboldi A, 2023, 'An epithelial cell-derived metabolite tunes immunoglobulin A secretion by gut-resident plasma cells', Nature Immunology, 24, pp. 531 - 544, http://dx.doi.org/10.1038/s41590-022-01413-w

Journal articles | 2023

Epstein RJ; Lin FPY; Brink RA; Blackburn J, 2023, 'Synonymous alterations of cancer-associated Trp53 CpG mutational hotspots cause fatal developmental jaw malocclusions but no tumors in knock-in mice', PLoS ONE, 18, http://dx.doi.org/10.1371/journal.pone.0284327

Journal articles | 2023

Frascoli M; Ferraj E; Miu B; Malin J; Spidale NA; Cowan J; Shissler SC; Brink R; Xu Y; Cyster JG; Bhandoola A; Kang J; Reboldi A, 2023, 'Skin γδ T cell inflammatory responses are hardwired in the thymus by oxysterol sensing via GPR183 and calibrated by dietary cholesterol', Immunity, 56, pp. 562 - 575.e6, http://dx.doi.org/10.1016/j.immuni.2023.01.025

Journal articles | 2023

Grootveld AK; Kyaw W; Panova V; Lau AWY; Ashwin E; Seuzaret G; Dhenni R; Bhattacharyya ND; Khoo WH; Biro M; Mitra T; Meyer-Hermann M; Bertolino P; Tanaka M; Hume DA; Croucher PI; Brink R; Nguyen A; Bannard O; Phan TG, 2023, 'Apoptotic cell fragments locally activate tingible body macrophages in the germinal center', Cell, 186, pp. 1144 - 1161.e18, http://dx.doi.org/10.1016/j.cell.2023.02.004

Journal articles | 2023

Masle-Farquhar E; Jeelall Y; White J; Bier J; Deenick EK; Brink R; Horikawa K; Goodnow CC, 2023, 'CARD11 gain-of-function mutation drives cell-autonomous accumulation of PD-1⁺ ICOS^high activated T cells, T-follicular, T-regulatory and T-follicular regulatory cells', Frontiers in Immunology, 14, http://dx.doi.org/10.3389/fimmu.2023.1095257

Journal articles | 2023

Nguyen T; Lau A; Bier J; Cooke KC; Lenthall H; Ruiz-Diaz S; Avery DT; Brigden H; Zahra D; Sewell WA; Droney L; Okada S; Asano T; Abolhassani H; Chavoshzadeh Z; Abraham RS; Rajapakse N; Klee EW; Church JA; Williams A; Wong M; Burkhart C; Uzel G; Croucher DR; James DE; Ma CS; Brink R; Tangye SG; Deenick EK, 2023, 'Human PIK3R1 mutations disrupt lymphocyte differentiation to cause activated PI3Kδ syndrome 2', The Journal of experimental medicine, 220, pp. e20221020, http://dx.doi.org/10.1084/jem.20221020

Journal articles | 2023

Thai LM; O'Reilly L; Reibe-Pal S; Sue N; Holliday H; Small L; Schmitz-Peiffer C; Dhenni R; Wang-Wei Tsai V; Norris N; Yau B; Zhang X; Lee K; Yan C; Shi YC; Kebede MA; Brink R; Cooney GJ; Irvine KM; Breit SN; Phan TG; Swarbrick A; Biden TJ, 2023, 'β-cell function is regulated by metabolic and epigenetic programming of islet-associated macrophages, involving Axl, Mertk, and TGFβ receptor signaling', iScience, 26, http://dx.doi.org/10.1016/j.isci.2023.106477

Journal articles | 2022

Bartonicek N; Rouet R; Warren J; Loetsch C; Rodriguez GS; Walters S; Lin F; Zahra D; Blackburn J; Hammond JM; Reis ALM; Deveson IW; Zammit N; Zeraati M; Grey S; Christ D; Mattick JS; Chtanova T; Brink R; Dinger ME; Weatheritt RJ; Sprent J; King C, 2022, 'The retroelement Lx9 puts a brake on the immune response to virus infection', Nature, 608, pp. 757 - 765, http://dx.doi.org/10.1038/s41586-022-05054-9

Journal articles | 2022

Bier J; Brink R; Tangye S; Deenick EK, 2022, 'T cell extrinsic mechanics explaining the T cell hyperactivation seen in Activated PI3K delta Syndrome', JOURNAL OF IMMUNOLOGY, 208, http://dx.doi.org/10.4049/jimmunol.208.Supp.159.05

Journal articles | 2022

Ceglia S; Berthelette A; Howley K; Li Y; Yiew NKH; Xu Y; Brink RA; Cyster JG; Hooper LV; Randolph GJ; Reboldi A, 2022, 'Epithelial-derived oxysterol production tunes intestinal IgA secretion against commensals and enteric pathogen in tissue', The Journal of Immunology, 208, pp. 115.07 - 115.07, http://dx.doi.org/10.4049/jimmunol.208.supp.115.07

Journal articles | 2022

Chandrakanthan V; Rorimpandey P; Zanini F; Chacon D; Olivier J; Joshi S; Kang YC; Knezevic K; Huang Y; Qiao Q; Oliver RA; Unnikrishnan A; Carter DR; Lee B; Brownlee C; Power C; Brink R; Mendez-Ferrer S; Enikolopov G; Walsh W; Göttgens B; Taoudi S; Beck D; Pimanda JE, 2022, 'Mesoderm-derived PDGFRA⁺ cells regulate the emergence of hematopoietic stem cells in the dorsal aorta', Nature Cell Biology, 24, pp. 1211 - 1225, http://dx.doi.org/10.1038/s41556-022-00955-3

Journal articles | 2022

Deenick E; Lau A; Nguyen T; Bier J; Brink R; Tangye S, 2022, 'Analysing the cellular mechanisms underlying activated PI3K delta Syndrome (APDS) reveals differences between APDS1 and APDS2', JOURNAL OF IMMUNOLOGY, 208, http://dx.doi.org/10.4049/jimmunol.208.Supp.159.15

Journal articles | 2022

Dvorscek AR; McKenzie CI; Robinson MJ; Ding Z; Pitt C; O'Donnell K; Zotos D; Brink R; Tarlinton DM; Quast I, 2022, 'IL-21 has a critical role in establishing germinal centers by amplifying early B cell proliferation', EMBO Reports, 23, http://dx.doi.org/10.15252/embr.202254677

Journal articles | 2022

Masle-Farquhar E; Jackson KJL; Peters TJ; Al-Eryani G; Singh M; Payne KJ; Rao G; Avery DT; Apps G; Kingham J; Jara CJ; Skvortsova K; Swarbrick A; Ma CS; Suan D; Uzel G; Chua I; Leiding JW; Heiskanen K; Preece K; Kainulainen L; O'Sullivan M; Cooper MA; Seppänen MRJ; Mustjoki S; Brothers S; Vogel TP; Brink R; Tangye SG; Reed JH; Goodnow CC, 2022, 'STAT3 gain-of-function mutations connect leukemia with autoimmune disease by pathological NKG2D^hi CD8⁺ T cell dysregulation and accumulation', Immunity, 55, pp. 2386 - 2404.e8, http://dx.doi.org/10.1016/j.immuni.2022.11.001

Journal articles | 2022

Munoz MA; Skinner OP; Masle-Farquhar E; Jurczyluk J; Xiao Y; Fletcher EK; Kristianto E; Hodson MP; O’Donoghue SI; Kaur S; Brink R; Zahra DG; Deenick EK; Perry KA; Robertson AAB; Mehr S; Hissaria P; Mulders-Manders CM; Simon A; Rogers MJ, 2022, 'Increased core body temperature exacerbates defective protein prenylation in mouse models of mevalonate kinase deficiency', Journal of Clinical Investigation, 132, http://dx.doi.org/10.1172/JCI160929

Journal articles | 2022

Neopane K; Kozlov N; Negoita F; Murray-Segal L; Brink R; Hoque A; Ovens AJ; Tjin G; McAloon LM; Yu D; Ling NXY; Sanders MJ; Oakhill JS; Scott JW; Steinberg GR; Loh K; Kemp BE; Sakamoto K; Galic S, 2022, 'Blocking AMPK β1 myristoylation enhances AMPK activity and protects mice from high-fat diet-induced obesity and hepatic steatosis', Cell Reports, 41, http://dx.doi.org/10.1016/j.celrep.2022.111862

Journal articles | 2022

Quast I; Dvorscek AR; Pattaroni C; Steiner TM; McKenzie CI; Pitt C; O'Donnell K; Ding Z; Hill DL; Brink R; Robinson MJ; Zotos D; Tarlinton DM, 2022, 'Interleukin-21, acting beyond the immunological synapse, independently controls T follicular helper and germinal center B cells', Immunity, 55, pp. 1414 - 1430.e5, http://dx.doi.org/10.1016/j.immuni.2022.06.020

Journal articles | 2021

Burnett DL; Jackson KJL; Langley DB; Aggrawal A; Stella AO; Johansen MD; Balachandran H; Lenthall H; Rouet R; Walker G; Saunders BM; Singh M; Li H; Henry JY; Jackson J; Stewart AG; Witthauer F; Spence MA; Hansbro NG; Jackson C; Schofield P; Milthorpe C; Martinello M; Schulz SR; Roth E; Kelleher A; Emery S; Britton WJ; Rawlinson WD; Karl R; Schäfer S; Winkler TH; Brink R; Bull RA; Hansbro PM; Jäck HM; Turville S; Christ D; Goodnow CC, 2021, 'Immunizations with diverse sarbecovirus receptor-binding domains elicit SARS-CoV-2 neutralizing antibodies against a conserved site of vulnerability', Immunity, 54, pp. 2908 - 2921.e6, http://dx.doi.org/10.1016/j.immuni.2021.10.019

Journal articles | 2021

Lau AWY; Turner VM; Bourne K; Hermes JR; Chan TD; Brink R, 2021, 'BAFFR controls early memory B cell responses but is dispensable for germinal center function', Journal of Experimental Medicine, 218, http://dx.doi.org/10.1084/JEM.20191167

Journal articles | 2021

Masle-Farquhar E; Russell A; Li Y; Zhu F; Rui L; Brink R; Goodnow CC, 2021, 'Loss-of-function of Fbxo10, encoding a post-translational regulator of BCL2 in lymphomas, has no discernible effect on BCL2 or B lymphocyte accumulation in mice', PLoS ONE, 16, http://dx.doi.org/10.1371/journal.pone.0237830

Journal articles | 2021

McDonald MM; Khoo WH; Ng PY; Xiao Y; Zamerli J; Thatcher P; Kyaw W; Pathmanandavel K; Grootveld AK; Moran I; Butt D; Nguyen A; Corr A; Warren S; Biro M; Butterfield NC; Guilfoyle SE; Komla-Ebri D; Dack MRG; Dewhurst HF; Logan JG; Li Y; Mohanty ST; Byrne N; Terry RL; Simic MK; Chai R; Quinn JMW; Youlten SE; Pettitt JA; Abi-Hanna D; Jain R; Weninger W; Lundberg M; Sun S; Ebetino FH; Timpson P; Lee WM; Baldock PA; Rogers MJ; Brink R; Williams GR; Bassett JHD; Kemp JP; Pavlos NJ; Croucher PI; Phan TG, 2021, 'Erratum: Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption (Cell (2021) 184(5) (1330–1347.e13), (S0092867421001525), (10.1016/j.cell.2021.02.002))', Cell, 184, pp. 1940, http://dx.doi.org/10.1016/j.cell.2021.03.010

Journal articles | 2021

McDonald MM; Khoo WH; Ng PY; Xiao Y; Zamerli J; Thatcher P; Kyaw W; Pathmanandavel K; Grootveld AK; Moran I; Butt D; Nguyen A; Warren S; Biro M; Butterfield NC; Guilfoyle SE; Komla-Ebri D; Dack MRG; Dewhurst HF; Logan JG; Li Y; Mohanty ST; Byrne N; Terry RL; Simic MK; Chai R; Quinn JMW; Youlten SE; Pettitt JA; Abi-Hanna D; Jain R; Weninger W; Lundberg M; Sun S; Ebetino FH; Timpson P; Lee WM; Baldock PA; Rogers MJ; Brink R; Williams GR; Bassett JHD; Kemp JP; Pavlos NJ; Croucher PI; Phan TG; Corr A, 2021, 'Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption', Cell, 184, pp. 1330 - 1347.e13, http://dx.doi.org/10.1016/j.cell.2021.02.002

Journal articles | 2021

Rouet R; Mazigi O; Walker GJ; Langley DB; Sobti M; Schofield P; Lenthall H; Jackson J; Ubiparipovic S; Henry JY; Abayasingam A; Burnett D; Kelleher A; Brink R; Bull RA; Turville S; Stewart AG; Goodnow CC; Rawlinson WD; Christ D, 2021, 'Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1 antibodies', mAbs, 13, http://dx.doi.org/10.1080/19420862.2021.1922134

Journal articles | 2021

Sundling C; Lau AWY; Bourne K; Young C; Laurianto C; Hermes JR; Menzies RJ; Butt D; Kräutler NJ; Zahra D; Suan D; Brink R, 2021, 'Positive selection of IgG⁺ over IgM⁺ B cells in the germinal center reaction', Immunity, 54, pp. 988 - 1001.e5, http://dx.doi.org/10.1016/j.immuni.2021.03.013

Journal articles | 2021

Youlten SE; Kemp JP; Logan JG; Ghirardello EJ; Sergio CM; Dack MRG; Guilfoyle SE; Leitch VD; Butterfield NC; Komla-Ebri D; Chai RC; Corr AP; Smith JT; Mohanty ST; Morris JA; McDonald MM; Quinn JMW; McGlade AR; Bartonicek N; Jansson M; Hatzikotoulas K; Irving MD; Beleza-Meireles A; Rivadeneira F; Duncan E; Richards JB; Adams DJ; Lelliott CJ; Brink R; Phan TG; Eisman JA; Evans DM; Zeggini E; Baldock PA; Bassett JHD; Williams GR; Croucher PI, 2021, 'Osteocyte transcriptome mapping identifies a molecular landscape controlling skeletal homeostasis and susceptibility to skeletal disease', Nature Communications, 12, pp. 2444, http://dx.doi.org/10.1038/s41467-021-22517-1

Journal articles | 2021

Young C; Brink R, 2021, 'The unique biology of germinal center B cells', Immunity, 54, pp. 1652 - 1664, http://dx.doi.org/10.1016/j.immuni.2021.07.015

Journal articles | 2020

Burnett DL; Schofield P; Langley DB; Jackson J; Bourne K; Wilson E; Porebski BT; Buckle AM; Brink R; Goodnow CC; Christ D, 2020, 'Conformational diversity facilitates antibody mutation trajectories and discrimination between foreign and self-antigens', Proceedings of the National Academy of Sciences of the United States of America, 117, pp. 22341 - 22350, http://dx.doi.org/10.1073/pnas.2005102117

Journal articles | 2020

Hoffman NJ; Whitfield J; Janzen NR; Belhaj MR; Galic S; Murray-Segal L; Smiles WJ; Ling NXY; Dite TA; Scott JW; Oakhill JS; Brink R; Kemp BE; Hawley JA, 2020, 'Genetic loss of AMPK-glycogen binding destabilises AMPK and disrupts metabolism', Molecular Metabolism, 41, pp. 101048, http://dx.doi.org/10.1016/j.molmet.2020.101048

Journal articles | 2020

Lau A; Avery DT; Jackson K; Lenthall H; Volpi S; Brigden H; Russell AJ; Bier J; Reed JH; Smart JM; Cole T; Choo S; Gray PE; Berglund LJ; Hsu P; Wong M; O'Sullivan M; Boztug K; Meyts I; Uzel G; Notarangelo LD; Brink R; Goodnow CC; Tangye SG; Deenick EK, 2020, 'Activated PI3Kd breaches multiple B cell tolerance checkpoints and causes autoantibody production', Journal of Experimental Medicine, 217, http://dx.doi.org/10.1084/jem_20191336

Journal articles | 2020

Lau AW; Brink R, 2020, 'Selection in the germinal center', Current Opinion in Immunology, 63, pp. 29 - 34, http://dx.doi.org/10.1016/j.coi.2019.11.001

Journal articles | 2020

Masle-Farquhar E; Payne K; Singh M; Rao G; Al-Eryani G; Jara C; Jackson K; Brink RA; Tangye S; Reed J; Goodnow CC, 2020, 'The effects of germline STAT3-activating mutations from autoimmunity and lymphoid malignancy on mouse and human T cells', The Journal of Immunology, 204, pp. 142.35 - 142.35, http://dx.doi.org/10.4049/jimmunol.204.supp.142.35

Journal articles | 2020

Rouet R; Mazigi O; Walker G; Langley D; Sobti M; Schofield P; Lenthall H; Jackson J; Ubiparipovic S; Henry J; Abayasingam A; Burnett D; Kelleher A; Brink R; Bull R; Turville S; Stewart A; Goodnow C; Rawlinson W; Christ D, 2020, 'Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1 antibodies', , http://dx.doi.org/10.1101/2020.12.14.422791

Journal articles | 2020

Singh M; Jackson KJL; Wang JJ; Schofield P; Field MA; Koppstein D; Peters TJ; Burnett DL; Rizzetto S; Nevoltris D; Masle-Farquhar E; Faulks ML; Russell A; Gokal D; Hanioka A; Horikawa K; Colella AD; Chataway TK; Blackburn J; Mercer TR; Langley DB; Goodall DM; Jefferis R; Gangadharan Komala M; Kelleher AD; Suan D; Rischmueller M; Christ D; Brink R; Luciani F; Gordon TP; Goodnow CC; Reed JH, 2020, 'Lymphoma Driver Mutations in the Pathogenic Evolution of an Iconic Human Autoantibody', Cell, 180, pp. 878 - 894.e19, http://dx.doi.org/10.1016/j.cell.2020.01.029

Journal articles | 2020

Toboso-Navasa A; Gunawan A; Morlino G; Nakagawa R; Taddei A; Damry D; Patel Y; Chakravarty P; Janz M; Kassiotis G; Brink R; Eilers M; Calado DP, 2020, 'Restriction of memory b cell differentiation at the germinal center b cell positive selection stage', Journal of Experimental Medicine, 217, http://dx.doi.org/10.1084/jem.20191933

Journal articles | 2020

Weinmann AS; Youngblood BA; Smale ST; Brink R; Schatz DG; McHeyzer-Williams M, 2020, 'A Future Outlook on Molecular Mechanisms of Immunity', Trends in Immunology, 41, pp. 549 - 555, http://dx.doi.org/10.1016/j.it.2020.05.005

Journal articles | 2020

Young C; Brink R, 2020, 'Germinal centers and autoantibodies', Immunology and Cell Biology, 98, pp. 480 - 489, http://dx.doi.org/10.1111/imcb.12321

Journal articles | 2019

Bier J; Rao G; Payne K; Brigden H; French E; Pelham SJ; Lau A; Lenthall H; Edwards ESJ; Smart JM; Cole TS; Choo S; Joshi AY; Abraham RS; O'Sullivan M; Boztug K; Meyts I; Gray PE; Berglund LJ; Hsu P; Wong M; Holland SM; Notarangelo LD; Uzel G; Ma CS; Brink R; Tangye SG; Deenick EK, 2019, 'Activating mutations in PIK3CD disrupt the differentiation and function of human and murine CD4⁺ T cells', Journal of Allergy and Clinical Immunology, 144, pp. 236 - 253, http://dx.doi.org/10.1016/j.jaci.2019.01.033

Journal articles | 2019

Moran I; Avery DT; Payne K; Lenthall H; Davies EG; Burns S; Ip W; Oleastro MM; Reisli I; Guner S; Keles S; Notarangelo L; Deenick EK; Goodnow CC; Zahra D; Brink R; Wong M; Tangye SG; Ma CS; Phan TG, 2019, 'B cell–intrinsic requirement for STK4 in humoral immunity in mice and human subjects', Journal of Allergy and Clinical Immunology, 143, pp. 2302 - 2305, http://dx.doi.org/10.1016/j.jaci.2019.02.010

Journal articles | 2019

Zammit N; Siggs OM; Gray P; King C; Christ D; Goodnow CC; Grey S; Cowley M; Craig M; Dinger M; Ziegler J; Villanueva J; Cultrone D; Brink R, 2019, 'Phospho-tuning immunity through Denisovan, modern human and mouse TNFAIP3 gene variants', bioRxiv, pp. 589507, http://dx.doi.org/10.1101/589507

Journal articles | 2019

Zammit NW; Siggs OM; Gray PE; Horikawa K; Langley DB; Walters SN; Daley SR; Loetsch C; Warren J; Yap JY; Cultrone D; Russell A; Malle EK; Villanueva JE; Cowley MJ; Gayevskiy V; Dinger ME; Brink R; Zahra D; Chaudhri G; Karupiah G; Whittle B; Roots C; Bertram E; Yamada M; Jeelall Y; Enders A; Clifton BE; Mabbitt PD; Jackson CJ; Watson SR; Jenne CN; Lanier LL; Wiltshire T; Spitzer MH; Nolan GP; Schmitz F; Aderem A; Porebski BT; Buckle AM; Abbott DW; Ziegler JB; Craig ME; Benitez-Aguirre P; Teo J; Tangye SG; King C; Wong M; Cox MP; Phung W; Tang J; Sandoval W; Wertz IE; Christ D; Goodnow CC; Grey ST, 2019, 'Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity', Nature Immunology, 20, pp. 1299 - 1310, http://dx.doi.org/10.1038/s41590-019-0492-0

Journal articles | 2018

Avery DT; Kane A; Nguyen T; Lau A; Nguyen A; Lenthall H; Payne K; Shi W; Brigden H; French E; Bier J; Hermes JR; Zahra D; Sewell WA; Butt D; Elliott M; Boztug K; Meyts I; Choo S; Hsu P; Wong M; Berglund LJ; Gray P; O’Sullivan M; Cole T; Holland SM; Ma CS; Burkhart C; Corcoran LM; Phan TG; Brink R; Uzel G; Deenick EK; Tangye SG; Bier Nogueira J, 2018, 'Germline-activating mutations in PIK3CD compromise B cell development and function', Journal of Experimental Medicine, 215, pp. 2073 - 2095, http://dx.doi.org/10.1084/jem.20180010

Journal articles | 2018

Brink R; Phan TG, 2018, 'Self-Reactive B Cells in the Germinal Center Reaction', Annual Review of Immunology, 36, pp. 339 - 357, http://dx.doi.org/10.1146/annurev-immunol-051116-052510

Journal articles | 2018

Burnett DL; Langley DB; Schofield P; Hermes JR; Chan TD; Jackson J; Bourne K; Reed JH; Patterson K; Porebski BT; Brink R; Christ D; Goodnow CC, 2018, 'Germinal center antibody mutation trajectories are determined by rapid self/foreign discrimination', Science, 360, pp. 223 - 226, http://dx.doi.org/10.1126/science.aao3859

Journal articles | 2018

Byrne FL; Olzomer EM; Brink R; Hoehn KL, 2018, 'Knockout of glucose transporter GLUT6 has minimal effects on whole body metabolic physiology in mice', American Journal of Physiology - Endocrinology and Metabolism, 315, pp. E286 - E293, http://dx.doi.org/10.1152/ajpendo.00082.2018

Journal articles | 2018

Kara EE; Bastow CR; McKenzie DR; Gregor CE; Fenix KA; Babb R; Norton TS; Zotos D; Rodda LB; Hermes JR; Bourne K; Gilchrist DS; Nibbs RJ; Alsharifi M; Vinuesa CG; Tarlinton DM; Brink R; Hill GR; Cyster JG; Comerford I; McColl SR, 2018, 'Atypical chemokine receptor 4 shapes activated B cell fate', Journal of Experimental Medicine, 215, pp. 801 - 813, http://dx.doi.org/10.1084/jem.20171067

Journal articles | 2018

Moran I; Nguyen A; Khoo WH; Butt D; Bourne K; Young C; Hermes JR; Biro M; Gracie G; Ma CS; Munier CML; Luciani F; Zaunders J; Parker A; Kelleher AD; Tangye SG; Croucher PI; Brink R; Read MN; Phan TG, 2018, 'Memory B cells are reactivated in subcapsular proliferative foci of lymph nodes', Nature Communications, 9, pp. 3372, http://dx.doi.org/10.1038/s41467-018-05772-7

Journal articles | 2018

Thientosapol ES; Bosnjak D; Durack T; Stevanovski I; Van Geldermalsen M; Holst J; Jahan Z; Shepard C; Weninger W; Kim B; Brink R; Jolly CJ, 2018, 'SAMHD1 enhances immunoglobulin hypermutation by promoting transversion mutation', Proceedings of the National Academy of Sciences of the United States of America, 115, pp. 4921 - 4926, http://dx.doi.org/10.1073/pnas.1719771115

Journal articles | 2018

Wirasinha RC; Vijayan D; Smith NJ; Parnell GP; Swarbrick A; Brink R; King C; Stewart G; Booth DR; Batten M, 2018, 'GPR65 inhibits experimental autoimmune encephalomyelitis through CD4⁺ T cell independent mechanisms that include effects on iNKT cells', Immunology and Cell Biology, 96, pp. 128 - 136, http://dx.doi.org/10.1111/imcb.1031

Journal articles | 2017

Burnett DL; Parish IA; Masle-Farquhar E; Brink R; Goodnow CC, 2017, 'Murine LRBA deficiency causes CTLA-4 deficiency in Tregs without progression to immune dysregulation', Immunology and Cell Biology, 95, pp. 775 - 788, http://dx.doi.org/10.1038/icb.2017.50

Journal articles | 2017

Corpuz TM; Vazquez-Lombardi R; Luong JK; Warren J; Stolp J; Christ D; King C; Brink R; Sprent J; Webster KE, 2017, 'IL-2 shapes the survival and plasticity of IL-17-producing γδ T Cells', Journal of Immunology, 199, pp. 2366 - 2376, http://dx.doi.org/10.4049/jimmunol.1700335

Journal articles | 2017

Kräutler NJ; Suan D; Butt D; Bourne K; Hermes JR; Chan TD; Sundling C; Kaplan W; Schofield P; Jackson J; Basten A; Christ D; Brink R, 2017, 'Differentiation of germinal center B cells into plasma cells is initiated by high-affinity antigen and completed by Tfh cells', Journal of Experimental Medicine, 214, pp. 1259 - 1267, http://dx.doi.org/10.1084/jem.20161533

Journal articles | 2017

Langley DB; Crossett B; Schofield P; Jackson J; Zeraati M; Maltby D; Christie M; Burnett D; Brink R; Goodnow C; Christ D, 2017, 'Structural basis of antigen recognition: Crystal structure of duck egg lysozyme', Acta Crystallographica Section D: Structural Biology, 73, pp. 910 - 920, http://dx.doi.org/10.1107/S2059798317013730

Journal articles | 2017

Suan D; Kräutler NJ; Maag JLV; Butt D; Bourne K; Hermes JR; Avery DT; Young C; Statham A; Elliott M; Dinger ME; Basten A; Tangye SG; Brink R, 2017, 'CCR6 Defines Memory B Cell Precursors in Mouse and Human Germinal Centers, Revealing Light-Zone Location and Predominant Low Antigen Affinity', Immunity, 47, pp. 1142 - 1153.e4, http://dx.doi.org/10.1016/j.immuni.2017.11.022

Journal articles | 2017

Suan D; Sundling C; Brink R, 2017, 'Plasma cell and memory B cell differentiation from the germinal center', Current Opinion in Immunology, 45, pp. 97 - 102, http://dx.doi.org/10.1016/j.coi.2017.03.006

Journal articles | 2017

Torcellan T; Hampton HR; Bailey J; Tomura M; Brink R; Chtanova T, 2017, 'In vivo photolabeling of tumor-infiltrating cells reveals highly regulated egress of T-cell subsets from tumors', Proceedings of the National Academy of Sciences of the United States of America, 114, pp. 5677 - 5682, http://dx.doi.org/10.1073/pnas.1618446114

Journal articles | 2017

Villa M; Gialitakis M; Tolaini M; Ahlfors H; Henderson CJ; Wolf CR; Brink R; Stockinger B, 2017, 'Aryl hydrocarbon receptor is required for optimal B-cell proliferation', EMBO Journal, 36, pp. 116 - 128, http://dx.doi.org/10.15252/embj.201695027

Journal articles | 2017

Villanueva JE; Walters SN; Saito M; Malle EK; Zammit NW; Watson KA; Brink R; La Gruta NL; Alexander SI; Grey ST, 2017, 'Targeted deletion of Traf2 allows immunosuppression-free islet allograft survival in mice', Diabetologia, 60, pp. 679 - 689, http://dx.doi.org/10.1007/s00125-016-4198-7

Journal articles | 2017

Wensveen FM; Slinger E; van Attekum MH; Brink R; Eldering E, 2017, 'Erratum: Antigen-affinity controls pre-germinal center B cell selection by promoting Mcl-1 induction through BAFF receptor signaling', Scientific reports, 7, pp. 39366, http://dx.doi.org/10.1038/srep39366

Journal articles | 2016

Brink R, 2016, 'EBI2 unlocks the door to the Tfh cell nursery', Immunology and Cell Biology, 94, pp. 621 - 622, http://dx.doi.org/10.1038/icb.2016.52

Journal articles | 2016

Chevalier N; Macia L; Tan JK; Mason LJ; Robert R; Thorburn AN; Wong CHY; Tsai LM; Bourne K; Brink R; Yu D; Mackay CR, 2016, 'The Role of Follicular Helper T Cell Molecules and Environmental Influences in Autoantibody Production and Progression to Inflammatory Arthritis in Mice', Arthritis and Rheumatology, 68, pp. 1026 - 1038, http://dx.doi.org/10.1002/art.39481

Journal articles | 2016

Guy TV; Terry AM; Bolton HA; Hancock DG; Zhu E; Brink R; McGuire HM; Shklovskaya E; Fazekas De St Groth B, 2016, 'Collaboration between tumor-specific CD4⁺ T cells and B cells in anti-cancer immunity', Oncotarget, 7, pp. 30211 - 30229, http://dx.doi.org/10.18632/oncotarget.8797

Journal articles | 2016

Jung S; Schickel JN; Kern A; Knapp AM; Eftekhari P; Da Silva S; Jaulhac B; Brink R; Soulas-Sprauel P; Pasquali JL; Martin T; Korganow AS, 2016, 'Chronic bacterial infection activates autoreactive B cells and induces isotype switching and autoantigen-driven mutations', European Journal of Immunology, 46, pp. 131 - 146, http://dx.doi.org/10.1002/eji.201545810

Journal articles | 2016

Kane A; Lau A; Brink R; Tangye SG; Deenick EK, 2016, 'B-cell–specific STAT3 deficiency: Insight into the molecular basis of autosomal-dominant hyper-IgE syndrome', Journal of Allergy and Clinical Immunology, 138, pp. 1455 - 1458.e3, http://dx.doi.org/10.1016/j.jaci.2016.05.018

Journal articles | 2016

Nakagawa R; Leyland R; Meyer-Hermann M; Lu D; Turner M; Arbore G; Phan TG; Brink R; Vigorito E, 2016, 'MicroRNA-155 controls affinity-based selection by protecting c-MYC+B cells from apoptosis', Journal of Clinical Investigation, 126, pp. 377 - 388

Journal articles | 2016

Wensveen FM; Slinger E; Van Attekum MHA; Brink R; Eldering E, 2016, 'Antigen-affinity controls pre-germinal centser B cell selection by promoting Mcl-1 induction through BAFF receptor signaling', Scientific Reports, 6, pp. 35673, http://dx.doi.org/10.1038/srep35673

Journal articles | 2016

vijayan D; redzwan M; avery DT; wirasinha RC; brink R; walters G; adelstein S; kobayashi M; gray P; elliott M; king C; vinuesa C; ghilardi N; ma CS; Tangye SG; batten M, 2016, 'IL-27 Directly Enhances Germinal Center B Cell Activity and Potentiates Lupus in Sanroque Mice', Journal of Immunology, 197, pp. 3008 - 3017, http://dx.doi.org/10.4049/jimmunol.1600652

Journal articles | 2015

Brink R; Paus D; Bourne K; Hermes JR; Gardam S; Phan TG; Chan TD, 2015, 'The SWHEL system for high-resolution analysis of in vivo antigen-specific T-dependent B cell responses', Methods in Molecular Biology, 1291, pp. 103 - 123, http://dx.doi.org/10.1007/978-1-4939-2498-1_9

Journal articles | 2015

Butt D; Chan TD; Bourne K; Hermes JR; Nguyen A; Statham A; O'Reilly LA; Strasser A; Price S; Schofield P; Christ D; Basten A; Ma CS; Tangye SG; Phan TG; Rao VK; Brink R, 2015, 'FAS Inactivation Releases Unconventional Germinal Center B Cells that Escape Antigen Control and Drive IgE and Autoantibody Production', Immunity, 42, pp. 890 - 902, http://dx.doi.org/10.1016/j.immuni.2015.04.010

Journal articles | 2015

Chen Z; Shen H; Sun C; Yin L; Tang F; Zheng P; Liu Y; Brink R; Rui L, 2015, 'Myeloid cell TRAF3 promotes metabolic inflammation, insulin resistance, and hepatic steatosis in obesity', American Journal of Physiology - Endocrinology and Metabolism, 308, pp. E460 - E469, http://dx.doi.org/10.1152/ajpendo.00470.2014

Journal articles | 2015

Hampton HR; Bailey J; Tomura M; Brink R; Chtanova T, 2015, 'Microbe-dependent lymphatic migration of neutrophils modulates lymphocyte proliferation in lymph nodes', Nature Communications, 6, http://dx.doi.org/10.1038/ncomms8139

Journal articles | 2015

Jung S; Schickel JN; Kern A; Knapp AM; Eftekhari P; Da Silva S; Jaulhac B; Brink R; Soulas-Sprauel P; Pasquali JL; Martin T; Korganow AS, 2015, 'Chronic bacterial infection activates autoreactive B cells and induces isotype switching and autoantigen-driven mutations', European Journal of Immunology, http://dx.doi.org/10.1002/eji.201545810

Journal articles | 2015

Malle EK; Zammit NW; Walters SN; Koay YC; Wu J; Tan BM; Villanueva JE; Brink R; Loudovaris T; Cantley J; McAlpine SR; Hesselson D; Grey ST, 2015, 'Nuclear factor κB-inducing kinase activation as a mechanism of pancreatic β cell failure in obesity', Journal of Experimental Medicine, 212, pp. 1239 - 1254, http://dx.doi.org/10.1084/jem.20150218

Journal articles | 2015

McGuire HM; Vogelzang A; Warren J; Loetsch C; Natividad KD; Chan TD; Brink R; Batten M; King C, 2015, 'IL-21 and IL-4 collaborate to shape t-dependent antibody responses', Journal of Immunology, 195, pp. 5123 - 5135, http://dx.doi.org/10.4049/jimmunol.1501463

Journal articles | 2015

Suan D; Nguyen A; Moran I; Bourne K; Hermes JR; Arshi M; Hampton HR; Tomura M; Miwa Y; Kelleher AD; Kaplan W; Deenick EK; Tangye SG; Brink R; Chtanova T; Phan TG, 2015, 'T Follicular Helper Cells Have Distinct Modes of Migration and Molecular Signatures in Naive and Memory Immune Responses', Immunity, 42, pp. 704 - 718, http://dx.doi.org/10.1016/j.immuni.2015.03.002

Journal articles | 2015

Tangye SG; Brink R; Goodnow CC; Phan TG, 2015, 'SnapShot: Interactions between B Cells and T Cells', Cell, 162, pp. 926 - 926.e1, http://dx.doi.org/10.1016/j.cell.2015.07.055

Journal articles | 2015

Villanueva JE; Malle EK; Gardam S; Silveira PA; Zammit NW; Walters SN; Brink R; Grey ST, 2015, 'TRAF2 regulates peripheral CD8⁺ T-cell and NKT-cell homeostasis by modulating sensitivity to IL-15', European Journal of Immunology, http://dx.doi.org/10.1002/eji.201445416

Journal articles | 2015

Villanueva JE; Malle EK; Gardam S; Silveira PA; Zammit NW; Walters SN; Brink R; Grey ST, 2015, 'TRAF2 regulates peripheral CD8⁺ T-cell and NKT-cell homeostasis by modulating sensitivity to IL-15', European Journal of Immunology, 45, pp. 1820 - 1831, http://dx.doi.org/10.1002/eji.201445416

Journal articles | 2014

Brink R, 2014, 'LOX-1Unlocks Human Plasma Cell Potential', Immunity, 41, pp. 507 - 508, http://dx.doi.org/10.1016/j.immuni.2014.09.019

Journal articles | 2014

Brink R, 2014, 'The imperfect control of self-reactive germinal center B cells', Current Opinion in Immunology, 28, pp. 97 - 101, http://dx.doi.org/10.1016/j.coi.2014.03.001

Journal articles | 2014

Chang JH; Hu H; Jin J; Puebla-Osorio N; Xiao Y; Gilbert BE; Brink R; Ullrich SE; Sun SC, 2014, 'TRAF3 regulates the effector function of regulatory T cells and humoral immune responses', Journal of Experimental Medicine, 211, pp. 137 - 151, http://dx.doi.org/10.1084/jem.20131019

Journal articles | 2014

Chen Z; Brink R; Rui L, 2014, 'Deletion of TRAF3 in Myeloid Cells Ameliorates Dietary Insulin Resistance and Glucose Intolerance in Mice', ENDOCRINE REVIEWS, 35, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209805103127&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Journal articles | 2014

Chtanova T; Hampton HR; Waterhouse LA; Wood K; Tomura M; Miwa Y; Mackay CR; Brink R; Phan TG, 2014, 'Real-time interactive two-photon photoconversion of recirculating lymphocytes for discontinuous cell tracking in live adult mice', Journal of Biophotonics, 7, pp. 425 - 433, http://dx.doi.org/10.1002/jbio.201200175

Journal articles | 2014

Heinig K; Gätjen M; Grau M; Stache V; Anagnostopoulos I; Gerlach K; Niesner RA; Cseresnyes Z; Hauser AE; Lenz P; Hehlgans T; Brink R; Westermann J; Dörken B; Lipp M; Lenz G; Rehm A; Höpken UE, 2014, 'Access to follicular dendritic cells is a pivotal step in murine chronic lymphocytic leukemia b-cell activation and proliferation', Cancer Discovery, 4, pp. 1448 - 1465, http://dx.doi.org/10.1158/2159-8290.CD-14-0096

Journal articles | 2014

Malle EK; Tan BM; Walters SN; Zammit NW; Brink R; Cantley J; Grey ST, 2014, 'The non-canonical NF kappa B pathway as a novel player in beta cell dysfunction in diabetes', DIABETOLOGIA, 57, pp. S48 - S48, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000344386100098&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Journal articles | 2014

Sabouri Z; Schofield P; Horikawa K; Spierings E; Kipling D; Randall KL; Langley D; Roome B; Vazquez-Lombardi R; Rouet R; Hermes J; Chan TD; Brink R; Dunn-Walters DK; Christ D; Goodnow CC, 2014, 'Redemption of autoantibodies on anergic B cells by variable-region glycosylation and mutation away from self-reactivity', Proceedings of the National Academy of Sciences of the United States of America, 111, http://dx.doi.org/10.1073/pnas.1406974111

Journal articles | 2014

Webster KE; Kim HO; Kyparissoudis K; Corpuz TM; Pinget GV; Uldrich AP; Brink R; Belz GT; Cho JH; Godfrey DI; Sprent J, 2014, 'IL-17-producing NKT cells depend exclusively on IL-7 for homeostasis and survival', Mucosal Immunology, 7, pp. 1058 - 1067, http://dx.doi.org/10.1038/mi.2013.122

Journal articles | 2013

Gardam S; Brink R, 2013, 'Non-canonical NF-κB signaling initiated by BAFF influences B cell biology at multiple junctures', Frontiers in Immunology, 4

Journal articles | 2013

Gardam S; Brink R, 2013, 'Non-canonical NF-κB signaling initiated by BAFF influences B cell biology at multiple junctures', Frontiers in Immunology, 4, http://dx.doi.org/10.3389/fimmu.2014.00509

Journal articles | 2013

Gatto D; Brink R, 2013, 'B cell localization: Regulation by EBI2 and its oxysterol ligand', Trends in Immunology, 34, pp. 336 - 341, http://dx.doi.org/10.1016/j.it.2013.01.007

Journal articles | 2013

Gatto D; Wood K; Caminschi I; Murphy-Durland D; Schofield P; Christ D; Karupiah G; Brink R, 2013, 'Erratum: The chemotactic receptor EBI2 regulates the homeostasis, localization and immunological function of splenic dendritic cells (Nature Immunology (2013) 14 (446-453))', Nature Immunology, 14, pp. 876, http://dx.doi.org/10.1038/ni0813-876e

Journal articles | 2013

Gatto D; Wood KA; Caminschi I; Murphy-durland D; Schofield PR; Christ DU; Brink R, 2013, 'The chemotactic receptor EBI2 regulates the homeostasis, localization and immunological function of splenic dendritic cells', Nature Immunology, 14, pp. 446 - 453, http://dx.doi.org/10.1038/ni.2555

Journal articles | 2013

He J; Tsai LM; Leong YA; Hu X; Ma CS; Chevalier N; Sun X; Vandenberg K; Rockman S; Ding Y; Zhu L; Wei W; Wang C; Karnowski A; Belz GT; Ghali JR; Cook MC; Riminton DS; Veillette A; Schwartzberg PL; Mackay F; Brink R; Tangye SG; Vinuesa CG; Mackay CR; Li Z; Yu D, 2013, 'Circulating precursor CCR7^loPD-1^hi CXCR5⁺ CD4⁺ T cells indicate tfh cell activity and promote antibody responses upon antigen reexposure', Immunity, 39, pp. 770 - 781, http://dx.doi.org/10.1016/j.immuni.2013.09.007

Journal articles | 2013

Natividad KDT; Junankar S; Mohd redzwan N; Wirasinha RC; King C; Brink R; Swarbrick A; Batten ML; Nair R, 2013, 'Interleukin-27 Signaling Promotes Immunity against Endogenously Arising Murine Tumors', PLoS ONE, 8, pp. e57469, http://dx.doi.org/10.1371/journal.pone.0057469

Journal articles | 2013

Ochiai K; Maienschein-Cline M; Simonetti G; Chen J; Rosenthal R; Brink R; Chong A; Klein U; Dinner A; Singh H; Sciammas R, 2013, 'Transcriptional Regulation of Germinal Center B and Plasma Cell Fates by Dynamical Control of IRF4', Immunity, 38, pp. 918 - 929, http://dx.doi.org/10.1016/j.immuni.2013.04.009

Journal articles | 2013

Tangye SG; Ma CS; Brink R; Deenick EK, 2013, 'The good, the bad and the ugly-T FH cells in human health and disease', Nature Reviews Immunology, 13, pp. 412 - 426, http://dx.doi.org/10.1038/nri3447

Journal articles | 2013

Wheeler ML; Dong MB; Brink R; Zhong XP; De Franco AL, 2013, 'Diacylglycerol kinase ζ limits B cell antigen receptor-dependent activation of ERK Signaling to inhibit early antibody responses', Science Signaling, 6, http://dx.doi.org/10.1126/scisignal.2004189

Journal articles | 2013

Xiao Y; Jin J; Chang M; Chang JH; Hu H; Zhou X; Brittain GC; Stansberg C; Torkildsen Ø; Wang X; Brink R; Cheng X; Sun SC, 2013, 'Peli1 promotes microglia-mediated CNS inflammation by regulating Traf3 degradation', Nature Medicine, 19, pp. 595 - 602, http://dx.doi.org/10.1038/nm.3111

Journal articles | 2013

Yau IW; Cato MH; Jellusova J; De Mendoza TH; Brink R; Rickert RC, 2013, 'Censoring of self-reactive B cells by follicular dendritic cell-displayed self-antigen', Journal of Immunology, 191, pp. 1082 - 1090, http://dx.doi.org/10.4049/jimmunol.1201569

Journal articles | 2012

Chan TD; Brink R, 2012, 'Affinity-based selection and the germinal center response', Immunological Reviews, 247, pp. 11 - 23, http://dx.doi.org/10.1111/j.1600-065X.2012.01118.x

Journal articles | 2012

Chen Z; Sheng L; Shen H; Zhao Y; Wang S; Brink R; Rui L, 2012, 'Hepatic TRAF2 regulates glucose metabolism through enhancing glucagon responses', Diabetes, 61, pp. 566 - 573, http://dx.doi.org/10.2337/db11-0474

Journal articles | 2012

Krautler NJ; Kana V; Kranich J; tian Y; Perera D; Lemm D; Schwarz P; Armulik A; Browning JL; Tallquist M; Buch T; Oliveira-martins JB; Zhu C; Hermann M; Wagner U; Brink R; Heikenwalder M; Aguzzi A, 2012, 'Follicular dendritic cells emerge from ubiquitous perivascular precursors', Cell, 150, pp. 194 - 206, http://dx.doi.org/10.1016/j.cell.2012.05.032

Journal articles | 2012

Tangye SG; Brink R, 2012, 'A helping hand from neutrophils in T cell-independent antibody responses?', Nature Immunology, 13, pp. 111 - 113, http://dx.doi.org/10.1038/ni.2214

Journal articles | 2012

Villanueva J; Walters SN; Marino E; Brink R; Grey ST, 2012, 'TRAF2 Governs the T Cell Alloimmune Response', TRANSPLANTATION, 94, pp. 14 - 14, http://dx.doi.org/10.1097/00007890-201211271-00025

Journal articles | 2011

Brink R, 2011, 'New friends for bone marrow plasma cells', Nature Immunology, 12, pp. 115 - 117, http://dx.doi.org/10.1038/ni0211-115

Journal articles | 2011

Deenick EK; Ma CS; Brink R; Tangye SG, 2011, 'Regulation of T follicular helper cell formation and function by antigen presenting cells', Current Opinion in Immunology, 23, pp. 111 - 118, http://dx.doi.org/10.1016/j.coi.2010.10.007

Journal articles | 2011

Gardam S; Turner V; Anderton H; Limaye S; Basten A; Koentgen F; Vaux D; Silke J; Brink R, 2011, 'Deletion of cIAP1 and cIAP2 in murine B lymphocytes constitutively activates cell survival pathways and inactivates the germinal center response', Blood, 117, pp. 4041 - 4051, http://dx.doi.org/10.1182/blood-2010-10-312793

Journal articles | 2011

Gatto D; Wood K; Brink R, 2011, 'EBI2 operates independently of but in co-operation with CXCR5 and CCR7 to direct B cell migration and organization in follicles and the germinal center', The Journal Of Immunology, 187, pp. 4621 - 4628, http://dx.doi.org/10.4049/jimmunol.1101542

Journal articles | 2011

Lee SK; Rigby RJ; Zotos D; Tsai LM; Kawamoto S; Marshall JL; Ramiscal RR; Chan TD; Gatto D; Brink R; Yu D; Fagarasan S; Tarlinton DM; Cunningham AF; Vinuesa C, 2011, 'B cell priming for extrafollicular antibody responses requires Bcl-6 expression by T cells', Journal of Experimental Medicine, 208, pp. 1377 - 1388, http://dx.doi.org/10.1084/jem.20102065

Journal articles | 2011

Tri P; Hampton H; Tomura M; Kanagawa O; Mackay C; Brink R; Chtanova T, 2011, 'Optical marking of migrating lymphocytes by two-photon photoconversion for single cell tracking and fate mapping', JOURNAL OF IMMUNOLOGY, 186, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209751703169&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Journal articles | 2011

Vu TT; Gatto D; Turner V; Funnell AP; Mak KS; Norton LJ; Kaplan W; Cowley MJ; Agenes F; Kirberg J; Brink R; Pearson RC; Crossley M, 2011, 'Impaired B cell development in the absence of Kruppel-like Factor 3.', Journal of Immunology, 187, pp. 5032 - 5042, http://dx.doi.org/10.4049/jimmunol.1101450

Journal articles | 2011

Wines B; Ramsland PA; Trist HM; Gardam S; Brink R; Fraser JD; Hogarth PM, 2011, 'Interaction of human, rat, and mouse immunoglobulin A (IgA) with staphylococcal superantigen-like 7 (SSL7) decoy protein and leukocyte IgA receptor', The Journal of Biological Chemistry, 286, pp. 33118 - 33124, http://dx.doi.org/10.1074/jbc.M111.272252

Journal articles | 2010

Brink R; Silk J, 2010, 'Regulation of TNFRSF and innate immune signalling complexes by TRAFs and cIAPs', Cell death and differentiation, 7, pp. 35 - 45, http://dx.doi.org/10.1038/cdd.2009.114

Journal articles | 2010

Goodnow CC; Vinuesa C; Randall KL; Mackay F; Brink R, 2010, 'Control systems and decision making for antibody production', Nature Immunology, 11, pp. 681 - 688, http://dx.doi.org/10.1038/ni.1900

Journal articles | 2010

Randall KL; Lambe T; Johnson A; Treanor B; Kucharska E; Domaschenz H; Whittle B; Tze LE; Enders A; Crockford TL; Bouriez-Jones T; Alston D; Cyster JG; Lenardo MJ; MacKay F; Deenick EK; Tangye SG; Chan TD; Camidge T; Brink R; Vinuesa CG; Batista FD; Cornall RJ; Goodnow CC, 2010, 'Erratum: Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production (Nature Immunology (2009) 10 (1283-1291))', Nature Immunology, 11, pp. 644, http://dx.doi.org/10.1038/ni0710-644a

Journal articles | 2010

Tangye SG; Palendira U; Low C; Deenick EK; Chan A; Ma CS; Brink R; Alvaro F; Cook MC; Sean Riminton D; Nichols KE; Schwartzberg PL, 2010, 'Sap is necessary for mediating antigen-specific effector functions of CD4+ AND CD8+ T cells', Pathology, 42, pp. S45 - S45, http://dx.doi.org/10.1097/01268031-201042001-00085

Journal articles | 2010

Turner ML; Corcoran L; Brink R; Hodgkin PH, 2010, 'High-affinity B cell receptor ligation by cognate antigen induces cytokine-independent isotype switching', Journal of Immunology, 184, pp. 6592 - 6599, http://dx.doi.org/10.4049/jimmunol.0903437

Journal articles | 2009

Chan TD; Gatto D; Wood K; Camidge T; Basten A; Brink R, 2009, 'Antigen affinity controls rapid T-dependent antibody production by driving the expansion rather than the differentiation or extrafollicular migration of early plasmablasts', Journal of Immunology, 183, pp. 3139 - 3149

Journal articles | 2009

Gatto D; Paus D; Basten A; MacKay CR; Brink R, 2009, 'Guidance of B Cells by the Orphan G Protein-Coupled Receptor EBI2 Shapes Humoral Immune Responses', Immunity, 31, pp. 259 - 269, http://dx.doi.org/10.1016/j.immuni.2009.06.016

Journal articles | 2009

Goodnow CC; Crosbie J; Adelstein S; Lavoie TB; Smith-Gill SJ; Brink RA; Pritchard-Briscoe H; Wotherspoon JS; Loblay RH; Raphael K; Trent RJ; Basten A, 2009, 'Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice (Reprinted from Nature, vol 334, pg 676-682, 1988)', JOURNAL OF IMMUNOLOGY, 183, pp. 5442 - 5448, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000271488500004&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Journal articles | 2009

Goodnow CC; Crosbie J; Adelstein S; Lavoie TB; Smith-Gill SJ; Brink RA; Pritchard-Briscoe H; Wotherspoon JS; Loblay RH; Raphael K; Trent RJ; Basten A, 2009, 'Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice.', Journal of immunology (Baltimore, Md. : 1950), 183, pp. 5442 - 5448

Journal articles | 2009

Linterman MA; Rigby RJ; Wong R; Silva D; Withers D; Anderson G; Verma NK; Brink R; Hutloff A; Goodnow CC; Vinuesa C, 2009, 'Roquin differentiates the specialized functions of duplicated T cell costimulatory receptor genes CD28 and ICOS', Immunity, 30, pp. 228 - 241, http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19217324

Journal articles | 2009

Linterman MA; Rigby RJ; Wong R; Yu D; Brink R; Cannons J; Schwartzberg P; Cook M; Walters G; Vinuesa C, 2009, 'Follicular helper T cells are required for systemic autoimmunity', Journal of Experimental Medicine, 206, pp. 561 - 576

Journal articles | 2009

Randall KL; Lambe T; Johnson A; Treanor B; Kucharska E; Domaschenz H; Whittle B; Tze LE; Enders A; Crockford TL; Bouriez-Jones T; Alston D; Cyster JG; Lenardo MJ; Mackay F; Deenick EK; Tangye SG; Chan TD; Camidge T; Brink R; Vinuesa C; Batista FD; Cornall RJ; Goodnow CC, 2009, 'Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production', Nature Immunology, 10, pp. 1283 - 1291, http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19898472

Journal articles | 2009

Walters SN; Webster K; Sutherland AP; Gardam S; Groom JR; Liuwantara D; Marino E; Thaxton J; Weinberg A; Mackay F; Brink R; Sprent J; Grey S, 2009, 'Increased CD4+Foxp3+ T cells in BAFF-transgenic mice suppress T cell effector responses', Journal of Immunology, 182, pp. 793 - 801, http://www.ncbi.nlm.nih.gov/pubmed/19124722

Journal articles | 2008

Brink R; Phan TA; Paus D; Chan TV, 2008, 'Visualizing the effects of antigen affinity on T-dependent B-cell differentiation', Immunology and Cell Biology, 86, pp. 31 - 39, http://dx.doi.org/10.1038/sj.icb.7100143

Journal articles | 2008

Gardam S; Sierro F; Basten A; Mackay F; Brink R, 2008, 'TRAF2 and TRAF3 signal adapters act cooperatively to control the maturation and survival signals delivered to B cells by the BAFF receptor', Immunity, 28, pp. 391 - 401, http://dx.doi.org/10.1016/j.immuni.2008.01.009

Journal articles | 2008

Vince J; Chau D; Callus B; Wong W; Hawkins C; Schneider P; McKinlay M; Benetatos C; Condon S; Chunduru S; Yeoh GH; Brink R; Vaux D; Silke J, 2008, 'TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1-TRAF2 complex to sensitize tumor cells to TNF alpha', Journal of Cell Biology, 182, pp. 171 - 184

Journal articles | 2008

Vince JE; Chau D; Callus B; Wong WW-L; Hawkins CJ; Schneider P; McKinlay M; Benetatos CA; Condon SM; Chunduru SK; Yeoh G; Brink R; Vaux DL; Silke J, 2008, 'TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1–TRAF2 complex to sensitize tumor cells to TNFα', The Journal of Experimental Medicine, 205, pp. i18 - i18, http://dx.doi.org/10.1084/jem2058oia18

Journal articles | 2007

Brink R, 2007, 'Germinal-center B cells in the zone', Immunity, 26, pp. 552 - 554

Journal articles | 2007

Mackay F; Silveira PA; Brink R, 2007, 'B cells and the BAFF/APRIL axis: fast-forward on autoimmunity and signaling', Current Opinion in Immunology, 19, pp. 327 - 336

Journal articles | 2007

Vince J; Wong W; Khan N; Feltham R; Chau D; Ahmed A; Benetatos C; Chunduru S; Condon S; McKinlay M; Brink R; Leverkus M; Tergaonkar V; Schneider P; Callus B; Koentgen F; Vaux D; Silke J, 2007, 'IAP antagonists target cIAP1 to induce TNF alpha- dependent apoptosis', Cell, 131, pp. 682 - 693

Journal articles | 2006

Brink R, 2006, 'Regulation of B cell self-tolerance by BAFF', Seminars in Immunology, 18, pp. 276 - 283

Journal articles | 2006

Paus D; Tri GP; Chan TD; Gardam S; Basten A; Brink R, 2006, 'Antigen recognition strength regulates the choice between extrafollicular plasma cell and germinal center B cell differentiation', Journal of Experimental Medicine, 203, pp. 1081 - 1091, http://dx.doi.org/10.1084/jem.20060087

Journal articles | 2006

Phan TG; Paus D; Chan TD; Turner ML; Nutt SL; Basten A; Brink R, 2006, 'High affinity germinal center B cells are actively selected into the plasma cell compartment', Journal of Experimental Medicine, 203, pp. 2419 - 2424, http://dx.doi.org/10.1084/jem.20061254

Journal articles | 2005

Grech AP; Gardam S; Chan T; Quinn R; Gonzales E; Basten A; Brink R, 2005, 'Tumor necrosis factor receptor 2 (TNFR2) signaling is negatively regulated by a novel, carboxyl-terminal TNFR-associated factor 2 (TRAF2)-binding site', Journal of Biological Chemistry, 280, pp. 31572 - 31581, http://dx.doi.org/10.1074/jbc.M504849200

Journal articles | 2005

Tri GP; Gardam S; Basten A; Brink R, 2005, 'Altered migration, recruitment, and somatic hypermutation in the early response of marginal zone B cells to T cell-dependent antigen', Journal of Immunology, 174, pp. 4567 - 4578, http://dx.doi.org/10.4049/jimmunol.174.8.4567

Journal articles | 2004

Avery DT; Kalled SL; Ellyard JI; Ambrose C; Bixler SA; Thien M; Brink R; Mackay F; Hodgkin PD; Tangye SG, 2004, 'BAFF selectively enhances the survival of plasmablasts generated from human memory B cells', Journal of Clinical Investigation, 113, pp. 1069 - 1069, http://dx.doi.org/10.1172/jci18025e1

Journal articles | 2004

Avery DT; Kalled SL; Ellyard JI; Ambrose C; Bixler SA; Thien M; Brink R; Mackay F; Hodgkin PD; Tangye SG, 2004, 'Erratum: BAFF selectively enhances the survival of plasmablasts generated from human memory B cells (Journal of Clinical Investigation (2003) 112 (286-297) doi:10.1172/JCI200318025)', Journal of Clinical Investigation, 113, pp. 1069, http://dx.doi.org/10.1172/JCI200318025C

Journal articles | 2004

Grech AP; Amesbury M; Chan T; Gardam S; Basten A; Brink R, 2004, 'TRAF2 differentially regulates the canonical and noncanonical pathways of NF-κB activation in mature B cells', Immunity, 21, pp. 629 - 642, http://dx.doi.org/10.1016/j.immuni.2004.09.011

Journal articles | 2003

Avery DT; Kalled SL; Ellyard JI; Ambrose C; Bixler SA; Thien M; Brink R; MacKay F; Hodgkin PD; Tangye SG, 2003, 'BAFF selectively enhances the survival of plasmablasts generated from human memory B cells', Journal of Clinical Investigation, 112, pp. 286 - 297, http://dx.doi.org/10.1172/JCI18025

Journal articles | 2003

Cook AJL; Oganesian L; Harumal P; Basten A; Brink R; Jolly CJ, 2003, 'Reduced Switching in SCID B Cells Is Associated with Altered Somatic Mutation of Recombined S Regions', Journal of Immunology, 171, pp. 6556 - 6564, http://dx.doi.org/10.4049/jimmunol.171.12.6556

Journal articles | 2003

Phan TG; Amesbury M; Gardam S; Crosbie J; Hasbold J; Hodgkin PD; Basten A; Brink R, 2003, 'B cell receptor-independent stimuli trigger immunoglobulin (Ig) class switch recombination and production of IgG autoantibodies by anergic self-reactive B cells', Journal of Experimental Medicine, 197, pp. 845 - 860, http://dx.doi.org/10.1084/jem.20022144

Journal articles | 2000

Grech A; Quinn R; Srinivasan D; Badoux X; Brink R, 2000, 'Complete structural characterisation of the mammalian and Drosophila TRAF genes: Implications for TRAF evolution and the role of RING finger splice variants', Molecular Immunology, 37, pp. 721 - 734, http://dx.doi.org/10.1016/S0161-5890(00)00098-5

Journal articles | 1998

Brink R; Lodish HF, 1998, 'Tumor necrosis factor receptor (TNFR)-associated factor 2A (TRAF2A), a TRAF2 splice variant with an extended RING finger domain that inhibits TNFR2- mediated NF-κB activation', Journal of Biological Chemistry, 273, pp. 4129 - 4134, http://dx.doi.org/10.1074/jbc.273.7.4129

Journal articles | 1995

Brink R; Goodnow CC; Basten A, 1995, 'IgD expression on B cells is more efficient than IgM but both receptors are functionally equivalent in up‐regulation CD80/CD86 co‐stimulatory molecules', European Journal of Immunology, 25, pp. 1980 - 1984, http://dx.doi.org/10.1002/eji.1830250727

Journal articles | 1994

Brink R; Fulcher DA; Goodnow CC; Basten A, 1994, 'Differential regulation of early and late stages of B lymphocyte development by the μ and δ membrane heavy chains of Ig', International Immunology, 6, pp. 1905 - 1916, http://dx.doi.org/10.1093/intimm/6.12.1905

Journal articles | 1994

Eris JM; Basten A; Brink R; Doherty K; Kehry MR; Hodgkin PD, 1994, 'Anergic self-reactive B cells present self antigen and respond normally to CD40-dependent T-cell signals but are defective in antigen-receptor-mediated functions', Proceedings of the National Academy of Sciences of the United States of America, 91, pp. 4392 - 4396, http://dx.doi.org/10.1073/pnas.91.10.4392

Journal articles | 1992

Brink R; Goodnow CC; Crosbie J; Adams E; Ens J; Mason DY; Hartley SB; Basten A, 1992, 'Immunoglobulin M and D antigen receptors are both capable of mediating B lymphocyte activation, deletion, or anergy after interaction with specific antigen', Journal of Experimental Medicine, 176, pp. 991 - 1005

Journal articles | 1991

Basten A; Brink R; Peake P; Adams E; Crosbie J; Hartley S; Goodnow CC, 1991, 'Self Tolerance in the B‐Cell Repertoire', Immunological Reviews, 122, pp. 5 - 19, http://dx.doi.org/10.1111/j.1600-065X.1991.tb00593.x

Journal articles | 1991

Basten A; Brink R; Peake P; Adams E; Crosbie J; Hartley S; Goodnow CC, 1991, 'Self tolerance in the B-cell repertoire', Immunological Reviews

Journal articles | 1991

Goodnow CC; Brink R; Adams E, 1991, 'Breakdown of self-tolerance in anergic B lymphocytes', Nature, 352, pp. 532 - 536, http://dx.doi.org/10.1038/352532a0

Journal articles | 1991

Hartley SB; Crosbie J; Brink R; Kantor AB; Basten A; Goodnow CC, 1991, 'Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens', Nature, 353, pp. 765 - 769, http://dx.doi.org/10.1038/353765a0

Journal articles | 1989

GOODNOW CC; CROSBIE J; ADELSTEIN S; LAVOIE TB; SMITHGILL SJ; MASON DY; JORGENSEN H; BRINK RA; PRITCHARDBRISCOE H; LOUGHNAN M; LOBLAY RH; TRENT RJ; BASTEN A, 1989, 'CLONAL SILENCING OF SELF-REACTIVE LYMPHOCYTES-B IN A TRANSGENIC MOUSE MODEL', COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 54, pp. 907 - 920, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1989JX74600035&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Journal articles | 1989

Goodnow CC; Crosbie J; Jorgensen H; Brink RA; Basten A, 1989, 'Induction of self-tolerance in mature peripheral B lymphocytes', Nature, 342, pp. 385 - 391, http://dx.doi.org/10.1038/342385a0

Journal articles | 1988

Goodnow CC; Crosbie J; Adelstein S; Lavoie TB; Smith-Gill SJ; Brink RA; Pritchard-Briscoe H; Wotherspoon JS; Loblay RH; Raphael K; Trent RJ; Basten A, 1988, 'Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice', Nature, 334, pp. 676 - 682, http://dx.doi.org/10.1038/334676a0
Preprints | 2024

Bier J; Lau A; Jackson KJL; Ruiz-Diaz S; Brink R; Tangye S; Deenick E, 2024, Both T and B cells contribute to dysregulated activation and differentiation of CD4⁺T cells in Activated PI3K delta syndrome 1, http://dx.doi.org/10.1101/2024.08.04.606503

Preprints | 2024

Young C; Singh M; Jackson KJL; Field MA; Peters TJ; Angioletti-Uberti S; Frenkel D; Ravishankar S; Gupta M; Wang JJ; Agapiou D; Faulks ML; Al-Eryani G; Luciani F; Gordon TP; Reed JH; Danta M; Carr A; Kelleher AD; Dore GJ; Matthews G; Brink R; Bull RA; Suan D; Goodnow CC, 2024, Self-reactive B cells traverse a perfect storm of somatic mutagenesis to cause a virus-induced autoimmune disease, http://dx.doi.org/10.1101/2024.01.07.574561

Conference Papers | 2023

Barnet MB; Masle-Farquhar E; Russell A; Burnett DL; Jackson KJL; Brink R; Heller G; Yang C; Prokopec S; Behren A; Davis ID; Peters GD; Boyer MJ; John T; Nagrial A; Gao B; Blinman P; Kao SC-H; Cebon JS; Goodnow CC, 2023, 'Association of common inherited NOD2 mutations with exceptional response to immune checkpoint inhibitors', in JOURNAL OF CLINICAL ONCOLOGY, LIPPINCOTT WILLIAMS & WILKINS, IL, Chicago, presented at Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), IL, Chicago, 02 June 2023 - 06 June 2023

Conference Abstracts | 2023

Barnet MB; Masle-Farquhar E; Russell A; Burnett DL; Jackson KJL; Brink R; Heller G; Yang C; Prokopec S; Behren A; Davis ID; Peters GD; Boyer MJ; John T; Nagrial A; Gao B; Blinman P; Kao SC-H; Cebon JS; Goodnow CC, 2023, 'Association of common inherited NOD2 mutations with exceptional response to immune checkpoint inhibitors.', in Journal of Clinical Oncology, American Society of Clinical Oncology (ASCO), Vol. 41, pp. 2514 - 2514, http://dx.doi.org/10.1200/jco.2023.41.16_suppl.2514

Preprints | 2022

Dvorscek AR; McKenzie CI; Robinson MJ; Ding Z; Pitt C; O’Donnell K; Zotos D; Brink R; Tarlinton DM; Quast I, 2022, IL-21 has a critical role in establishing germinal centers by amplifying early B cell proliferation, http://dx.doi.org/10.1101/2022.01.21.476732

Preprints | 2022

Masle-Farquhar E; Jackson KJL; Peters T; Al-Eryani G; Singh M; Payne K; Rao G; Apps G; Kingham J; Jara C; Skvortsova K; Swarbrick A; Ma C; Suan D; Uzel G; Chua I; Leiding J; Heiskanen K; Preece K; Kainulainen L; O’Sullivan M; Cooper M; Seppänen MRJ; Mustjoki S; Brothers S; Vogel T; Brink R; Tangye S; Reed J; Goodnow C, 2022, STAT3gain-of-function mutations connect leukemia with autoimmune disease by pathological dysregulation of NKG2D^hiCD8 killer T cells, http://dx.doi.org/10.1101/2022.02.11.480027

Preprints | 2022

Munoz M; Skinner O; Masle-Farquhar E; Jurczyluk J; Xiao Y; Fletcher E; Kristianto E; Hodson M; O’Donoghue S; Kaur S; Brink R; Zahra D; Deenick E; Perry K; Robertson AAB; Mehr S; Hissaria P; Mulders-Manders C; Simon A; Rogers M, 2022, Increased core body temperature exacerbates defective protein prenylation in mouse avatars of mevalonate kinase deficiency, http://dx.doi.org/10.1101/2022.02.28.480959

Preprints | 2022

Zammit N; Gray P; Siggs O; Yap JY; Russell A; Cultrone D; Warren J; Walters S; Brink R; Zahra D; Burnett D; Gayevskiy V; Minoche A; Ziegler J; Craig M; Wong M; Benitez-Aguirre P; Teo J; Cowley M; Dinger M; Tangye S; Burke C; Phan T; Goodnow C; Grey S, 2022, Environmental and genetic disease modifiers of haploinsufficiency of A20, http://dx.doi.org/10.1101/2022.03.19.485004

Conference Papers | 2021

Bier J; Lau A; Brink RA; Ruiz-Diaz S; Lenthall H; Tangye S; Deenick E, 2021, 'T cell dysfunction in Activated P13K delta Syndrome explained by cell intrinsic and extrinsic components', in JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000713665800408&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Preprints | 2021

Masle-Farquhar E; Peters T; Jackson KJL; Singh M; Ma C; Suan D; Uzel G; Chua I; Leiding J; Heiskanen K; Preece K; Kainulainen L; O’Sullivan M; Cooper M; Seppänen MRJ; Mustjoki S; Brothers S; Vogel T; Brink R; Tangye S; Reed J; Goodnow C, 2021, Overactive STAT3 drives accumulation of disease-associated CD21^lowB cells, http://dx.doi.org/10.1101/2021.12.20.473595

Conference Papers | 2020

Masle-Farquhar E; Payne K; Singh M; Rao G; Al-Eryani G; Jara C; Jackson K; Brink RA; Tangye S; Reed J; Goodnow CC, 2020, 'The effects of germline STAT3-activating mutations from autoimmunity and lymphoid malignancy on mouse and human T cells', in JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, HI, Honolulu, presented at Annual Meeting of the American-Association-of-Immunologists - Immunology 2020, HI, Honolulu, 08 May 2020 - 12 May 2020, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000589972401141&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Preprints | 2020

Masle-Farquhar E; Russell A; Li Y; Zhu F; Rui L; Brink R; Goodnow C, 2020, Loss-of-function ofFbxo10, encoding a post-translational regulator of BCL2 in lymphomas, has no discernible effect on BCL2 or B lymphocyte accumulation in mice, http://dx.doi.org/10.1101/2020.08.05.237545

Preprints | 2020

Youlten SE; Kemp JP; Logan JG; Ghirardello EJ; Sergio CM; Dack MRG; Guilfoyle SE; Leitch VD; Butterfield NC; Komla-Ebri D; Chai RC; Corr AP; Smith JT; Mohanty S; Morris JA; McDonald MM; Quinn JMW; McGlade AR; Bartonicek N; Jansson M; Hatzikotoulas K; Irving MD; Beleza-Meireles A; Rivadeneira F; Duncan E; Richards JB; Adams DJ; Lelliott CJ; Brink R; Phan TG; Eisman JA; Evans DM; Zeggini E; Baldock PA; Bassett JHD; Williams GR; Croucher PI, 2020, Osteocyte Transcriptome Mapping Identifies a Molecular Landscape Controlling Skeletal Homeostasis and Susceptibility to Skeletal Disease, http://dx.doi.org/10.1101/2020.04.20.051409

Conference Abstracts | 2019

Masle-Farquhar E; Payne K; Jackson K; Rao G; Singh M; El-Eryani G; Brink R; Tangye S; Reed J; Goodnow C, 2019, 'The effects of germline STAT3-activating mutations from autoimmunity and lymphoid malignancy on mouse and human T cell development and function', in EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY, PEOPLES R CHINA, Beijing, Vol. 49, pp. 901 - 901, presented at 17th International Congress of Immunology of the International-Union-of-Immunological-Societies (IUIS), PEOPLES R CHINA, Beijing, 19 October 2019 - 23 October 2019, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000490026902546&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts | 2018

Barnet M; Jackson K; Gao B; Nagrial A; Boyer M; Cooper W; Hui R; Linton A; Tattersall M; Russell A; Gibson G; Cebon J; Long G; Menzies A; Scolyer R; Lacaze P; Brink R; Peters T; Cowley M; Gayevskiy V; Thomas D; Pinese M; Blinman P; Kao S; Goodnow C, 2018, 'Exploring the Germ-Line Contribution to Exceptional Response to PD-1/PD-L1 Inhibition in Patients with NSCLC by Whole Genome Sequencing', in JOURNAL OF THORACIC ONCOLOGY, ELSEVIER SCIENCE INC, Vol. 13, pp. S529 - S529, http://dx.doi.org/10.1016/j.jtho.2018.08.726

Conference Papers | 2018

Barnet MB; Jackson KJ; Gao B; Nagrial AM; Boyer MJ; Cooper WA; Hui R; Linton A; Tattersall MH; Gibson G; Cebon J; Long GV; Menzies AM; Scolyer RA; Lacaze P; Brink R; Peters T; Cowley M; Gayevskiy V; Thomas DM; Pinese M; Blinman P; Kao S; Goodnow CC, 2018, 'Exploring the germ-line contribution to exceptional response to PD-1/PD-L1 inhibition in patients with metastatic non-small-cell lung cancer by whole genome sequencing', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, IL, Chicago, presented at Annual Meeting of the American-Association-for-Cancer-Research (AACR), IL, Chicago, 14 April 2018 - 18 April 2018, http://dx.doi.org/10.1158/1538-7445.AM2018-LB-121

Conference Abstracts | 2017

Burnett D; Schofield P; Langley D; Brink R; Christ D; Goodnow CC, 2017, 'Somatic Hypermutation Serves two independent Functions: Antibody Maturation Away From Binding Self and Towards Binding Foreign', in EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY, GERMANY, Erlangen, Vol. 47, pp. 3 - 3, presented at 47th Annual Meeting of the German-Society-for-Immunology (DGFI), GERMANY, Erlangen, 12 September 2017 - 15 September 2017, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000418423100003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts | 2017

Eisman J; Croucher P; Baldock P; Nguyen T; Brink R; Hesselson D; Nguyen S; Moni M; Youlten S, 2017, 'Identification of anabolic bone genes using whole genome sequencing in high bone mass families.', in JOURNAL OF BONE AND MINERAL RESEARCH, WILEY 111 RIVER ST, HOBOKEN 07030-5774, NJ USA, Vol. 32, pp. S71 - S71, WILEY 111 RIVER ST, HOBOKEN 07030-5774, NJ USA

Conference Abstracts | 2017

McDonald M; Ng PY; Butt D; Pathmanandavel K; Biro M; Terry R; Khoo WH; Mohanty S; Simic M; Chai R; Quinn J; Pettitt J; Abi-Hanna D; Jain R; Weninger W; Baldock P; Rogers M; Brink R; Pavlos N; Croucher P; Phan T, 2017, 'Intravital imaging of osteoclasts in vivo reveals cellular recycling as a novel cell fate mechanism.', in JOURNAL OF BONE AND MINERAL RESEARCH, WILEY, CO, Denver, Vol. 32, pp. S37 - S37, presented at Annual Meeting of the American-Society-for-Bone-and-Mineral-Research (ASBMR), CO, Denver, 08 September 2017 - 11 September 2017, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000418869200110&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts | 2017

Sundling C; Butt D; Suan D; Lau A; Brink R, 2017, 'Counter-selection versus switching in the demise of IgM(+) germinal center B cells', in SCANDINAVIAN JOURNAL OF IMMUNOLOGY, WILEY, SWEDEN, Stockholm, Vol. 86, pp. 250 - 250, presented at 44th Annual Meeting of the Scandinavian-Society-for-Immunology (SSI), SWEDEN, Stockholm, 17 October 2017 - 20 October 2017, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000411865200010&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts | 2017

Torcellan T; Hampton HR; Bailey J; Tomura M; Brink R; Chtanova T, 2017, 'Using in vivo photolabeling to uncover the fate of tumour-infiltrating T cell migration in tumour immunity', in EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY, GERMANY, Erlangen, Vol. 47, pp. 64 - 64, presented at 47th Annual Meeting of the German-Society-for-Immunology (DGFI), GERMANY, Erlangen, 12 September 2017 - 15 September 2017, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000418423100064&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts | 2016

Burnett D; Schofield P; Christ D; Brink R; Goodnow C, 2016, 'Somatic hypermutation serves two independent functions: antibody maturation away from binding self and towards binding foreign', in EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY-BLACKWELL, AUSTRALIA, Melbourne, Vol. 46, pp. 803 - 804, presented at International Congress of Immunology (ICI), AUSTRALIA, Melbourne, 21 August 2016 - 26 August 2016, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000383610402005&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts | 2016

Butt D; Chan T; Bourne K; Hermes J; Strasser A; Tangye S; Phan T; Rao VK; Brink R, 2016, 'Rogue germinal center B cells: unconventional lymphocytes released by FAS inactivation that drive IgE and autoantibody production', in EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY-BLACKWELL, AUSTRALIA, Melbourne, Vol. 46, pp. 25 - 26, presented at International Congress of Immunology (ICI), AUSTRALIA, Melbourne, 21 August 2016 - 26 August 2016, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000383610400052&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts | 2016

Goodnow C; Reed J; Burnett D; Brink R; Christ D; Schofield P; Perotti S; Enders A; Ziegler J; Wainstein B; Roscioli T; Gray P, 2016, 'Redemption or Revolt of Forbidden Clones: Mutations, Autoantibodies and CTLA4-Ig Therapy', in EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY-BLACKWELL, AUSTRALIA, Melbourne, Vol. 46, pp. 3 - 3, presented at International Congress of Immunology (ICI), AUSTRALIA, Melbourne, 21 August 2016 - 26 August 2016, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000383610400007&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts | 2016

Kane A; Lau A; Brink R; Tangye S; Deenick E, 2016, 'STAT3 is a critical B-cell intrinsic regulator of functional antibody responses and IgE production', in EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY-BLACKWELL, AUSTRALIA, Melbourne, Vol. 46, pp. 849 - 849, presented at International Congress of Immunology (ICI), AUSTRALIA, Melbourne, 21 August 2016 - 26 August 2016, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000383610402097&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts | 2016

Kara E; Bastow C; Mckenzie D; Gregor C; Fenix K; Norton T; Zotos D; Rodda L; Vinuesa C; Tarlinton D; Brink R; Cyster J; Comerford I; Mccoll S, 2016, 'The atypical chemokine receptor ACKR4 shapes early antibody responses', in EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY-BLACKWELL, AUSTRALIA, Melbourne, Vol. 46, pp. 1261 - 1262, presented at International Congress of Immunology (ICI), AUSTRALIA, Melbourne, 21 August 2016 - 26 August 2016, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000391563600050&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts | 2016

Lau A; Chan T; Brink R, 2016, 'Control of germinal center and early memory B cell homeostasis by BAFFR', in EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY-BLACKWELL, AUSTRALIA, Melbourne, Vol. 46, pp. 1131 - 1131, presented at International Congress of Immunology (ICI), AUSTRALIA, Melbourne, 21 August 2016 - 26 August 2016, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000383610402670&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts | 2016

Lim EX; Figgett WA; Brink R; Mackay F, 2016, 'Loss of TACI expression allows self-reactive MZ B cells to escape deletion but not anergy', in EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY-BLACKWELL, AUSTRALIA, Melbourne, Vol. 46, pp. 716 - 716, presented at International Congress of Immunology (ICI), AUSTRALIA, Melbourne, 21 August 2016 - 26 August 2016, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000383610401633&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts | 2016

McDonald M; Butt D; Terry R; Quinn J; Rogers M; Brink R; Croucher P; Phan T, 2016, 'Real-time intravital longitudinal imaging of osteoclast formation, function and fate during bone remodeling', in EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY-BLACKWELL, AUSTRALIA, Melbourne, Vol. 46, pp. 270 - 270, presented at International Congress of Immunology (ICI), AUSTRALIA, Melbourne, 21 August 2016 - 26 August 2016, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000383610400545&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts | 2016

Moran I; Nguyen A; Brink R; Phan TG, 2016, 'Where and how memory cells are reactivated in the secondary antibody response in the lymph node', in EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY-BLACKWELL, AUSTRALIA, Melbourne, Vol. 46, pp. 823 - 823, presented at International Congress of Immunology (ICI), AUSTRALIA, Melbourne, 21 August 2016 - 26 August 2016, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000383610402045&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts | 2016

Nguyen A; Moran I; Tanaka M; Tangye S; Brink R; Phan T, 2016, 'Dynamic changes in gene regulatory networks control subcapsular sinus macrophage fate and function', in EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY-BLACKWELL, AUSTRALIA, Melbourne, Vol. 46, pp. 430 - 430, presented at International Congress of Immunology (ICI), AUSTRALIA, Melbourne, 21 August 2016 - 26 August 2016, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000383610401057&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts | 2016

Shklovskaya E; Terry A; Guy T; Bolton H; Brink R; Fazekas de St Groth B, 2016, 'Interactions between CD4 T cells, regulatory T cells and B cells shape the immune response to tumours', in EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY, AUSTRALIA, Melbourne, Vol. 46, pp. 862 - 863, presented at International Congress of Immunology (ICI), AUSTRALIA, Melbourne, 21 August 2016 - 26 August 2016, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000383610402126&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts | 2016

Suan D; Krautler N; Butt D; Bourne K; Hermes J; Schofield P; Jackson J; Phan TG; Christ D; Brink R, 2016, 'Antigen-linked rather than T-FH cell-derived signals select high affinity germinal centre B cells for plasma cell differentiation', in EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY-BLACKWELL, AUSTRALIA, Melbourne, Vol. 46, pp. 296 - 296, presented at International Congress of Immunology (ICI), AUSTRALIA, Melbourne, 21 August 2016 - 26 August 2016, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000383610400596&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts | 2016

Suan D; Krautler N; Maag J; Butt D; Wood K; Hermes J; Priestley D; Statham A; Elliott M; Marcel D; Basten A; Tangye S; Brink R, 2016, 'Memory B cells develop from low-affinity clones in the germinal center light zone and are identified by CCR6 expression in mice and humans', in EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY-BLACKWELL, AUSTRALIA, Melbourne, Vol. 46, pp. 1132 - 1133, presented at International Congress of Immunology (ICI), AUSTRALIA, Melbourne, 21 August 2016 - 26 August 2016, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000383610402674&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts | 2016

Torcellan T; Hampton HR; Bailey J; Tomura M; Brink R; Chtanova T, 2016, 'Tumour-infiltrating T cells leave tumours to provide effector functions in draining lymph nodes', in EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY-BLACKWELL, AUSTRALIA, Melbourne, Vol. 46, pp. 1006 - 1007, presented at International Congress of Immunology (ICI), AUSTRALIA, Melbourne, 21 August 2016 - 26 August 2016, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000383610402420&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts | 2016

Vijayan D; Redzwan MN; Avery D; Wirasinha R; Brink R; Walters G; Adelstein S; Kobayashi M; Gray P; Elliott M; King C; Vinuesa C; Ghilardi N; Ma C; Tangye S; Batten M, 2016, 'IL-27 directly influences germinal center B cell development via STAT1', in EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY-BLACKWELL, AUSTRALIA, Melbourne, Vol. 46, pp. 1082 - 1082, presented at International Congress of Immunology (ICI), AUSTRALIA, Melbourne, 21 August 2016 - 26 August 2016, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000383610402571&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts | 2015

O'Reilly L; Cantley J; Turner V; Brink R; Schmitz-Peiffer C; Biden TJ, 2015, 'Deletion of PKC epsilon in islet-associated macrophages improves beta cell function', in DIABETOLOGIA, SPRINGER, SWEDEN, Stockholm, Vol. 58, pp. S219 - S219, presented at 51st Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), SWEDEN, Stockholm, 14 September 2015 - 18 September 2015, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000359820901131&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Papers | 2014

Espeli M; Sowerby JM; Linterman MA; Brink R; Smith KGC, 2014, 'The Inhibitory Receptor FcgammaRIIb Differentially Regulates Central and GC Tolerance', in SCANDINAVIAN JOURNAL OF IMMUNOLOGY, WILEY-BLACKWELL, SWEDEN, Uddevalla, pp. 216 - 216, presented at 18th Germinal Centre Conference, SWEDEN, Uddevalla, 11 September 2014 - 14 September 2014, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000340899200023&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Papers | 2014

Motallebzadeh R; Rehakova S; Bolton E; Linterman M; Brink R; Bradley JA; Pettigrew G, 2014, 'The functional role of tertiary lymphoid organs in allografts', in BRITISH JOURNAL OF SURGERY, WILEY-BLACKWELL, ENGLAND, Univ Cambridge, Robinson Coll, Cambridge, pp. 40 - 40, presented at Annual Meeting of the Society-of-Academic-and-Research-Surgery, ENGLAND, Univ Cambridge, Robinson Coll, Cambridge, 08 January 2014 - 09 January 2014, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000334502500130&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Papers | 2014

Villanueva J; Walters S; Saito M; Marino E; Malle E; Zammit N; Brink R; Alexander S; Grey S, 2014, 'Loss of TRAF2 Impairs Alloreactive CD4(+) T Cells and Maintains Tregs to Favour Islet Allograft Survival Without Exogenous Immunosuppression', in AMERICAN JOURNAL OF TRANSPLANTATION, WILEY-BLACKWELL, CA, San Francisco, pp. 40 - 40, presented at World Transplant Congress, CA, San Francisco, 26 July 2014 - 31 July 2014, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000338033300134&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Papers | 2014

Villanueva J; Walters S; Saito M; Marino E; Malle E; Zammit N; Brink R; Alexander S; Grey S, 2014, 'Loss of TRAF2 Impairs Alloreactive CD4(+) T Cells and Maintains Tregs to Favour Islet Allograft Survival Without Exogenous Immunosuppression.', in TRANSPLANTATION, LIPPINCOTT WILLIAMS & WILKINS, CA, San Francisco, pp. 40 - 40, presented at World Transplant Congress, CA, San Francisco, 26 July 2014 - 31 July 2014, http://dx.doi.org/10.1097/00007890-201407151-00133

Conference Papers | 2013

Malle EK; Walters SN; Zammit NW; Cantley J; Brink R; Grey ST, 2013, 'Intra-islet inflammation in type 2 diabetes: evidence that the E3 ligase TRAF2 is a key protective factor in beta cells', in DIABETOLOGIA, SPRINGER, SPAIN, Barcelona, pp. S54 - S54, presented at 49th Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), SPAIN, Barcelona, 23 September 2013 - 27 September 2013, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000329196900117&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Papers | 2013

Redzwan NM; Vijayan D; Ma C; Tangye S; Brink R; Vinuesa C; Batten M, 2013, 'IL-27 signals to both B and T cells support germinal center function and the development of GC-driven lupus', in CYTOKINE, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, CA, San Francisco, pp. 292 - 292, presented at Annual Joint Conference of the International-Cytokine-Society and the International-Society-for-Interferon-and-Cytokine-Research, CA, San Francisco, 29 September 2013 - 03 October 2013, http://dx.doi.org/10.1016/j.cyto.2013.06.210

Conference Papers | 2013

Villanueva J; Walters SN; Marino E; Saito M; Alexander S; Brink R; Grey ST, 2013, 'Permanent Survival of Islet Allografts and Delayed Rejection of Heart and Skin Allografts Without Exogenous Immunosuppression by Targeting TNF-Receptor Associated Factor 2', in TRANSPLANTATION, LIPPINCOTT WILLIAMS & WILKINS, CA, Monterey, pp. S62 - S62, presented at 14th World Congress of the International-Pancreas-and-Islet-Transplant-Association (IPITA), CA, Monterey, 24 September 2013 - 27 September 2013, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000330443500112&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Papers | 2011

Plummer PN; Taft R; Mattick J; McMillan N; Swarbrick A; Brink R; Mittal V; Mellick AS, 2011, 'MICRORNAS AS TOOLS TO TARGET BONE MARROW MEDIATED TUMOUR ANGIOGENESIS', in JOURNAL OF GENE MEDICINE, WILEY, AUSTRALIA, Univ Melbourne, Bio21 Inst, Parkville, pp. 430 - 430, presented at 7th Biennial Meeting of the Australasian-Gene-Therapy-Society, AUSTRALIA, Univ Melbourne, Bio21 Inst, Parkville, 04 May 2011 - 06 May 2011, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000297950900039&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Papers | 2011

Plummer PN; Taft R; Mattick J; McMillan N; Swarbrick A; Brink R; Mittal V; Mellick AS, 2011, 'MICRORNAS AS TOOLS TO TARGET BONE MARROW MEDIATED TUMOUR ANGIOGENESIS', in JOURNAL OF GENE MEDICINE, WILEY, AUSTRALIA, Univ Melbourne, Bio21 Inst, Parkville, pp. 443 - 443, presented at 7th Biennial Meeting of the Australasian-Gene-Therapy-Society, AUSTRALIA, Univ Melbourne, Bio21 Inst, Parkville, 04 May 2011 - 06 May 2011, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000297950900061&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Papers | 2010

Randall K; Lambe T; Johnson A; Kucharska E; Vinuesa C; Treanor B; Batista F; Chan T; Camidge T; Brink R; Cornall R; Goodnow C, 2010, 'Immunodeficiency and Abnormal B Cell Synapse Formation due to DOCK8 Mutations in Mice', in CLINICAL IMMUNOLOGY, ACADEMIC PRESS INC ELSEVIER SCIENCE, MA, Boston, pp. S17 - S17, presented at 10th Annual Meeting of the Federation-of-Clinical-Immunology-Societies, MA, Boston, 24 June 2010 - 27 June 2010, http://dx.doi.org/10.1016/j.clim.2010.03.055

Conference Papers | 2005

Phan TG; Paus D; Chan TD; Gardam S; Amesbury M; Crosbie J; Basten A; Brink R, 2005, 'Visuallising B cell responses to protein antigens of varying affinity in vivo', in TISSUE ANTIGENS, BLACKWELL PUBLISHING, AUSTRALIA, Melbourne, pp. 511 - 512, presented at 35th Annual SCientific Meeting of the Australasian-Society-for-Immunology/14th International HLA and Immunogenetics Workshops, AUSTRALIA, Melbourne, 29 November 2005 - 02 December 2005, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000233542700464&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Papers | 1989

BASTEN A; BRINK RA; MASON DY; CROSBIE J; GOODNOW CC, 1989, 'SELF-TOLERANCE IN B-CELLS FROM DIFFERENT LINES OF LYSOZYME DOUBLE-TRANSGENIC MICE', in MELCHERS F (ed.), PROGRESS IN IMMUNOLOGY, VOL 7, SPRINGER-VERLAG BERLIN, FED REP GER, BERLIN, pp. 377 - 384, presented at 7TH INTERNATIONAL CONGRESS OF IMMUNOLOGY, FED REP GER, BERLIN, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1989BP83Z00049&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Papers | 1989

Goodnow CC; Crosbie J; Adelstein S; Lavoie TB; Smith-Gill SJ; Mason DY; Jorgensen H; Brink RA; Pritchard-Briscoe H; Loughnan M; Loblay RH; Trent RJ; Basten A, 1989, 'Clonal silencing of self-reactive B lymphocytes in a transgenic mouse model', in Cold Spring Harbor Symposia on Quantitative Biology, pp. 907 - 920, http://dx.doi.org/10.1101/sqb.1989.054.01.106

Conference Papers | 1988

GOODNOW CC; CROSBIE J; ADELSTEIN S; LAVOIE TB; SMITHGILL SJ; BRINK RA; PRITCHARDBRISCOE H; WOTHERSPOON JS; LOBLAY RH; RAPHAEL K; TRENT RJ; BASTEN A, 1988, 'IMMUNOLOGICAL-TOLERANCE IN LYSOZYME ANTILYSOZYME TRANSGENIC MICE', in SMITHGILL SJ; SERCARZ EE (ed.), IMMUNE RESPONSE TO STRUCTURALLY DEFINED PROTEINS : THE LYSOZYME MODEL, ADENINE PRESS, MD, MARY WOODARD LASKER CTR HLTH RES & EDUC, BETHESDA, pp. 389 - 402, presented at WORKSHOP ON THE IMMUNOLOGY OF LYSOZYME, MD, MARY WOODARD LASKER CTR HLTH RES & EDUC, BETHESDA, 13 June 1988 - 15 June 1988, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1989BR20A00037&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Preprints |

Masle-Farquhar E; Peters TJ; Jackson KJL; Singh M; Ma CS; Suan D; Uzel G; Chua I; Leiding JW; Heiskanen K; Preece K; Kainulainen L; O’Sullivan M; Cooper MA; Seppänen MRJ; Mustjoki S; Brothers S; Vogel TP; Brink R; Tangye SG; Reed JH; Goodnow CC, Overactive STAT3 Drives Accumulation of Disease-Associated CD21 <sup>low</sup> B Cells, http://dx.doi.org/10.2139/ssrn.3996405

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Professor Robert Brink