Associate Professor Rowena Anne Bull
Associate Professor

Associate Professor Rowena Anne Bull

Medicine & Health
Biomedical Research Institute

I am an early career researcher studying viral evolution of RNA viruses, in particular, hepatitis C virus, norovirus and influenza. I have been investigating the viral and host factors that different RNA viruses use to generate diversity and maintain their survival in the population. We take an interdisciplinary approach involving cutting edge virological, immunological  and bioinformatic techniques. Our contribution to virology ranges from the development of virological in vitro based fitness assays, viral gene expression studies, molecular epidemiology, evolutionary analysis of adaptive immune responses against RNA viruses, and bioinformatics. A recent research focus has been the analysis of over 30 million nucleotides generated through next generation sequencing approaches in a longitudinal study of ten HCV infected patients (Bull, Luciani et al. PLoS pathogens 2011). 

Major Research Interests

  • Within-host evolutionary dynamics of RNA viruses including HCV, influenza, and NoV
  • Investigating the selective pressures of cellular and humoral immune responses against HCV

Research Experience

  • NHMRC Training Postdoctoral Research Fellow, School of Medical Sciences, University of New South Wales, UNSW. 2010 – continuing.
  • Visiting Research Scientist, Stanford University, USA. 2011
  • Postdocotoral Research Fellow in Microbiology and Molecular Biology, University of New South Wales, UNSW. 2007 - 2010
  • Visiting Research Fellow, La Trobe University, Australia. 2008
  • PhD in 2007 at the University of New South Wales, Australia, in Molecular Biology and funded by an Australian Postgraduate Award.
  • Visiting Research Scientist, National Institute of Infectious Diseases, NIID, Tokyo, Japan 2006
  • B.Sc (Hons 1st class) in Medical Microbiology and Immunobiology, University of New South Wales, Australia 
Phone
+61 2 9385 2777

Publications

  • Book Chapters | 2016
    Associate Professor Rowena Anne Bull
    Bull RA; Luciani F, 2016, 'Next-Generation Sequencing, What Has It Told Us So Far?', in Foodborne Viral Pathogens, CRC Press
    Book Chapters | 2010
    Associate Professor Rowena Anne Bull
    Bull RA; White PA, 2010, 'Genome organization and recombination', in Hansman GS; Jiang J; Green KY (ed.), Caliciviruses: Molecular and Cellular Virology, Caister Academic Press, Portland, USA, pp. 45 - 63, http://www.horizonpress.com/calicivirus
    Book Chapters | 2005
    Associate Professor Rowena Anne Bull
    Mciver CJ; Bull RA; Tu ET; Rawlinson WD; White PA, 2005, 'Norovirus and Sapovirus', in McIver CJ (ed.), A Compendium of Laboratory Diagnostic Methods for Common and Unusual Enteric Pathogens - an Australian Perspective, edn. 1, Australian Society of Microbiology, Australia, pp. 191 - 198
  • Journal articles | 2021
    Associate Professor Rowena Anne Bull
    Walker GJ; Naing Z; Stella AO; Yeang M; Caguicla J; Ramachandran V; Isaacs SR; Agapiou D; Bull RA; Stelzer-Braid S; Daly J; Gosbell IB; Hoad VC; Irving DO; Pink JM; Turville S; Kelleher AD; Rawlinson WD, 2021, 'Sars coronavirus-2 microneutralisation and commercial serological assays correlated closely for some but not all enzyme immunoassays', Viruses, vol. 13, pp. 247 - 247, http://dx.doi.org/10.3390/v13020247
    Journal articles | 2021
    Associate Professor Rowena Anne Bull
    Brasher NA; Adhikari A; Lloyd AR; Tedla N; Bull RA, 2021, 'Hepatitis c virus epitope immunodominance and b cell repertoire diversity', Viruses, vol. 13, pp. 983 - 983, http://dx.doi.org/10.3390/v13060983
    Journal articles | 2021
    Associate Professor Rowena Anne Bull
    Kim KW; Deveson IW; Pang CNI; Yeang M; Naing Z; Adikari T; Hammond JM; Stevanovski I; Beukers AG; Verich A; Yin S; McFarlane D; Wilkins MR; Stelzer-Braid S; Bull RA; Craig ME; van Hal SJ; Rawlinson WD, 2021, 'Respiratory viral co-infections among SARS-CoV-2 cases confirmed by virome capture sequencing', Scientific Reports, vol. 11, pp. 3934, http://dx.doi.org/10.1038/s41598-021-83642-x
    Journal articles | 2021
    Associate Professor Rowena Anne Bull
    Abayasingam A; Balachandran H; Agapiou D; Hammoud M; Rodrigo C; Keoshkerian E; Li H; Brasher NA; Christ D; Rouet R; Burnet D; Grubor-Bauk B; Rawlinson W; Turville S; Aggarwal A; Stella AO; Fichter C; Brilot F; Mina M; Post JJ; Hudson B; Gilroy N; Dwyer D; Sasson SC; Tea F; Pilli D; Kelleher A; Tedla N; Lloyd AR; Martinello M; Bull RA, 2021, 'Long-term persistence of RBD+ memory B cells encoding neutralizing antibodies in SARS-CoV-2 infection', Cell Reports Medicine, vol. 2, pp. 100228, http://dx.doi.org/10.1016/j.xcrm.2021.100228
    Journal articles | 2021
    Associate Professor Rowena Anne Bull
    Kalemera MD; Capella-Pujol J; Chumbe A; Underwood A; Bull RA; Schinkel J; Sliepen K; Grove J, 2021, 'Optimized cell systems for the investigation of hepatitis C virus E1E2 glycoproteins', Journal of General Virology, vol. 102, http://dx.doi.org/10.1099/JGV.0.001512
    Journal articles | 2021
    Associate Professor Rowena Anne Bull
    Rouet R; Mazigi O; Walker GJ; Langley DB; Sobti M; Schofield P; Lenthall H; Jackson J; Ubiparipovic S; Henry JY; Abayasingam A; Burnett D; Kelleher A; Brink R; Bull RA; Turville S; Stewart AG; Goodnow CC; Rawlinson WD; Christ D, 2021, 'Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1 antibodies', mAbs, vol. 13, pp. 1922134, http://dx.doi.org/10.1080/19420862.2021.1922134
    Journal articles | 2021
    Associate Professor Rowena Anne Bull
    Adhikari A; Eltahla A; Lloyd AR; Rodrigo C; Agapiou D; Bull RA; Tedla N, 2021, 'Optimisation and validation of a new method for antibody dependent cellular phagocytosis in hepatitis C virus infection', Journal of Immunological Methods, vol. 495, http://dx.doi.org/10.1016/j.jim.2021.113087
    Journal articles | 2021
    Associate Professor Rowena Anne Bull
    Zhao Y; Cai C; Samir J; Palgen JL; Keoshkerian E; Li H; Bull RA; Luciani F; An H; Lloyd AR, 2021, 'Human CD8 T-stem cell memory subsets phenotypic and functional characterization are defined by expression of CD122 or CXCR3', European Journal of Immunology, vol. 51, pp. 1732 - 1747, http://dx.doi.org/10.1002/eji.202049057
    Journal articles | 2021
    Associate Professor Rowena Anne Bull
    Riaz N; Leung P; Barton K; Smith MA; Carswell S; Bull R; Lloyd AR; Rodrigo C, 2021, 'Adaptation of Oxford Nanopore technology for hepatitis C whole genome sequencing and identification of within-host viral variants', BMC Genomics, vol. 22, pp. 148, http://dx.doi.org/10.1186/s12864-021-07460-1
    Journal articles | 2020
    Associate Professor Rowena Anne Bull
    Adikari TN; Riaz N; Sigera C; Leung P; Valencia BM; Barton K; Smith MA; Bull RA; Li H; Luciani F; Weeratunga P; Thein TL; Lim VWX; Leo YS; Rajapakse S; Fink K; Lloyd AR; Fernando D; Rodrigo C, 2020, 'Single molecule, near full-length genome sequencing of dengue virus', Scientific Reports, vol. 10, http://dx.doi.org/10.1038/s41598-020-75374-1
    Journal articles | 2020
    Associate Professor Rowena Anne Bull
    Bull RA; Adikari TN; Ferguson JM; Hammond JM; Stevanovski I; Beukers AG; Naing Z; Yeang M; Verich A; Gamaarachchi H; Kim KW; Luciani F; Stelzer-Braid S; Eden JS; Rawlinson WD; van Hal SJ; Deveson IW, 2020, 'Analytical validity of nanopore sequencing for rapid SARS-CoV-2 genome analysis', Nature Communications, vol. 11, pp. 6272, http://dx.doi.org/10.1038/s41467-020-20075-6
    Journal articles | 2020
    Associate Professor Rowena Anne Bull
    Brasher NA; Eltahla AA; Underwood A; Boo I; Rizzetto S; Walker MR; Rodrigo C; Luciani F; Maher L; Drummer HE; Tedla N; Lloyd AR; Bull RA, 2020, 'B cell immunodominance in primary hepatitis C virus infection', Journal of Hepatology, vol. 72, pp. 670 - 679, http://dx.doi.org/10.1016/j.jhep.2019.11.011
    Journal articles | 2020
    Associate Professor Rowena Anne Bull
    Walker MR; Eltahla AA; Mina MM; Li H; Lloyd AR; Bull RA, 2020, 'Envelope-specific IgG3 and IgG1 responses are associated with clearance of acute hepatitis C virus infection', Viruses, vol. 12, http://dx.doi.org/10.3390/v12010075
    Journal articles | 2020
    Associate Professor Rowena Anne Bull
    Helbig KJ; Bull RA; Ambrose R; Beard MR; Blanchard H; Böcking T; Chua B; Colmant AMG; Crosse KM; Purcell DFJ; Fraser J; Hayward JA; Hamilton ST; Husain M; MacDiarmid R; MacKenzie JM; Moseley GW; Nguyen THO; Quiñones-Mateu ME; Robinson K; Rodrigo C; Rodriguez-Andres J; Rudd PA; Werno A; White P; Young P; Speck P; Hibma M; Drummer HE; Tachedjian G, 2020, 'Tenth scientific biennial meeting of the australasian virology society - AVS10 2019', Viruses, vol. 12, http://dx.doi.org/10.3390/v12060621
    Journal articles | 2020
    Associate Professor Rowena Anne Bull
    Douglas MW; Tay ESE; Wang DS; Ong ATL; Wilson C; Phu A; Kok J; Dwyer DE; Bull RA; Lloyd AR; Applegate TL; Dore GJ; Howe AY; Harrigan R; George J, 2020, 'Impact of an Open Access Nationwide Treatment Model on Hepatitis C Virus Antiviral Drug Resistance', HEPATOLOGY COMMUNICATIONS, vol. 4, pp. 904 - 915, http://dx.doi.org/10.1002/hep4.1496
    Journal articles | 2020
    Associate Professor Rowena Anne Bull
    Mina M; Underwood A; Eltahla A; Wu BR; Walker MR; Bull RA; Lloyd AR, 2020, 'Anti-envelope antibody responses in highly exposed seronegative individuals may be associated with protection from HCV infection', Journal of Viral Hepatitis, vol. 27, pp. 1012 - 1021, http://dx.doi.org/10.1111/jvh.13339
    Journal articles | 2020
    Associate Professor Rowena Anne Bull
    Adikari TN; Di Giallonardo F; Leung P; Grifoni A; Sette A; Weiskopf D; Bull RA; Luciani F, 2020, 'Conserved epitopes with high HLA-I population coverage are targets of CD8+ T cells associated with high IFN-γ responses against all dengue virus serotypes', Scientific Reports, vol. 10, http://dx.doi.org/10.1038/s41598-020-77565-2
    Journal articles | 2020
    Associate Professor Rowena Anne Bull
    Walker G; Naing Z; Stella AO; Yeang M; Caguicla J; Ramachandran V; Isaacs S; Agapiou D; Bull R; Stelzer-Braid S; Daly J; Gosbell I; Hoad V; Irving D; Pink J; Turville S; Kelleher A; Rawlinson W, 2020, 'SARS Coronavirus-2 microneutralisation and commercial serological assays correlated closely for some but not all enzyme immunoassays', , http://dx.doi.org/10.1101/2020.12.07.20245696
    Journal articles | 2020
    Associate Professor Rowena Anne Bull
    Kalemera M; Cappella-Pujol J; Chumbe A; Underwood A; Bull R; Schinkel J; Sliepen K; Grove J, 2020, 'Optimised cell systems for the investigation of hepatitis C virus E1E2 glycoproteins', , http://dx.doi.org/10.1101/2020.06.18.159442
    Journal articles | 2019
    Associate Professor Rowena Anne Bull
    Pirozyan MR; Nguyen N; Cameron B; Luciani F; Bull RA; Zekry A; Lloyd AR, 2019, 'Chemokine-Regulated Recruitment of Antigen-Specific T-Cell Subpopulations to the Liver in Acute and Chronic Hepatitis C Infection', Journal of Infectious Diseases, vol. 219, pp. 1430 - 1438, http://dx.doi.org/10.1093/infdis/jiy679
    Journal articles | 2019
    Associate Professor Rowena Anne Bull
    Rodrigo C; Leung P; Lloyd AR; Bull RA; Luciani F; Grebely J; Dore GJ; Applegate T; Page K; Bruneau J; Cox AL; Osburn W; Kim AY; Shoukry NH; Lauer GM; Maher L; Schinkel J; Prins M; Hellard M; Eltahla AA, 2019, 'Genomic variability of within-host hepatitis C variants in acute infection', Journal of Viral Hepatitis, vol. 26, pp. 476 - 484, http://dx.doi.org/10.1111/jvh.13051
    Journal articles | 2019
    Associate Professor Rowena Anne Bull
    Kim KW; Horton JL; Pang CNI; Jain K; Leung P; Isaacs SR; Bull RA; Luciani F; Wilkins MR; Catteau J; Lipkin WI; Rawlinson WD; Briese T; Craig ME, 2019, 'Higher abundance of enterovirus A species in the gut of children with islet autoimmunity', Scientific Reports, vol. 9, pp. 1749, http://dx.doi.org/10.1038/s41598-018-38368-8
    Journal articles | 2019
    Associate Professor Rowena Anne Bull
    Wu BR; Eltahla AA; Keoshkerian E; Walker MR; Underwood A; Brasher NA; Agapiou D; Lloyd AR; Bull RA, 2019, 'A method for detecting hepatitis C envelope specific memory B cells from multiple genotypes using cocktail E2 tetramers', Journal of Immunological Methods, vol. 472, pp. 65 - 74, http://dx.doi.org/10.1016/j.jim.2019.06.016
    Journal articles | 2019
    Associate Professor Rowena Anne Bull
    Abayasingam A; Leung P; Eltahla A; Bull RA; Luciani F; Grebely J; Dore GJ; Applegate T; Page K; Bruneau J; Cox AL; Kim AY; Schinkel J; Shoukry NH; Lauer GM; Maher L; Hellard M; Prins M; Lloyd A; Rodrigo C, 2019, 'Genomic characterization of hepatitis C virus transmitted founder variants with deep sequencing', Infection, Genetics and Evolution, vol. 71, pp. 36 - 41, http://dx.doi.org/10.1016/j.meegid.2019.02.032
    Journal articles | 2019
    Associate Professor Rowena Anne Bull
    Keck ZY; Pierce BG; Lau P; Lu J; Wang Y; Underwood A; Bull RA; Prentoe J; Velázquez-Moctezuma R; Walker MR; Luciani F; Guest JD; Fauvelle C; Baumert TF; Bukh J; Lloyd AR; Foung SKH, 2019, 'Broadly neutralizing antibodies from an individual that naturally cleared multiple hepatitis c virus infections uncover molecular determinants for E2 targeting and vaccine design', PLoS Pathogens, vol. 15, pp. e1007772, http://dx.doi.org/10.1371/journal.ppat.1007772
    Journal articles | 2019
    Associate Professor Rowena Anne Bull
    Masavuli MG; Wijesundara DK; Underwood A; Christiansen D; Earnest-Silveira L; Bull R; Torresi J; Gowans EJ; Grubor-Bauk B, 2019, 'A hepatitis C virus DNA vaccine encoding a secreted, oligomerized form of envelope proteins is highly immunogenic and elicits neutralizing antibodies in vaccinated mice', Frontiers in Immunology, vol. 10, pp. 1145, http://dx.doi.org/10.3389/fimmu.2019.01145
    Journal articles | 2019
    Associate Professor Rowena Anne Bull
    Mekonnen ZA; Grubor-Bauk B; Masavuli MG; Shrestha AC; Ranasinghe C; Bull RA; Lloyd AR; Gowans EJ; Wijesundara DK, 2019, 'Toward DNA-based T-cell mediated vaccines to target HIV-1 and hepatitis C virus: Approaches to elicit localized immunity for protection', Frontiers in Cellular and Infection Microbiology, vol. 9, pp. 91, http://dx.doi.org/10.3389/fcimb.2019.00091
    Journal articles | 2019
    Associate Professor Rowena Anne Bull
    Walker MR; Leung P; Eltahla AA; Underwood A; Abayasingam A; Brasher NA; Li H; Wu BR; Maher L; Luciani F; Lloyd AR; Bull RA, 2019, 'Clearance of hepatitis C virus is associated with early and potent but narrowly-directed, Envelope-specific antibodies', Scientific Reports, vol. 9, pp. 13300, http://dx.doi.org/10.1038/s41598-019-49454-w
    Journal articles | 2018
    Associate Professor Rowena Anne Bull
    Isaacs SR; Kim KW; Cheng JX; Bull RA; Stelzer-Braid S; Luciani F; Rawlinson WD; Craig ME, 2018, 'Amplification and next generation sequencing of near full-length human enteroviruses for identification and characterisation from clinical samples', Scientific Reports, vol. 8, http://dx.doi.org/10.1038/s41598-018-30322-y
    Journal articles | 2018
    Associate Professor Rowena Anne Bull
    Underwood AP; Walker MR; Brasher NA; Eltahla AA; Maher L; Luciani F; Lloyd AR; Bull RA, 2018, 'Understanding the determinants of BnAb induction in acute HCV infection', Viruses, vol. 10, http://dx.doi.org/10.3390/v10110659
    Journal articles | 2018
    Associate Professor Rowena Anne Bull
    Wang Z; Zhu L; Nguyen THO; Wan Y; Sant S; Quiñones-Parra SM; Crawford JC; Eltahla AA; Rizzetto S; Bull RA; Qiu C; Koutsakos M; Clemens EB; Loh L; Chen T; Liu L; Cao P; Ren Y; Kedzierski L; Kotsimbos T; McCaw JM; La Gruta NL; Turner SJ; Cheng AC; Luciani F; Zhang X; Doherty PC; Thomas PG; Xu J; Kedzierska K, 2018, 'Clonally diverse CD38+HLA-DR+CD8+ T cells persist during fatal H7N9 disease', Nature Communications, vol. 9, http://dx.doi.org/10.1038/s41467-018-03243-7
    Journal articles | 2017
    Associate Professor Rowena Anne Bull
    Tohma K; Lepore CJ; Ford-Siltz LA; Parra GI, 2017, 'Phylogenetic Analyses Suggest that Factors Other Than the Capsid Protein Play a Role in the Epidemic Potential of GII.2 Norovirus.', mSphere, vol. 2, http://dx.doi.org/10.1128/mSphereDirect.00187-17
    Journal articles | 2017
    Associate Professor Rowena Anne Bull
    Rizzetto S; Eltahla AA; Lin P; Bull R; Lloyd AR; Ho JWK; Venturi V; Luciani F, 2017, 'Impact of sequencing depth and read length on single cell RNA sequencing data of T cells', Scientific Reports, vol. 7, http://dx.doi.org/10.1038/s41598-017-12989-x
    Journal articles | 2017
    Associate Professor Rowena Anne Bull
    Eltahla AA; Rodrigo C; Betz-Stablein B; Grebely J; Applegate T; Luciani F; Schinkel J; Dore GJ; Page K; Bruneau J; Morris MD; Cox AL; Kim AY; Shoukry NH; Lauer GM; Maher L; Hellard M; Prins M; Lloyd AR; Bull RA, 2017, 'Analysis of resistance-associated substitutions in acute hepatitis C virus infection by deep sequencing across six genotypes and three continents', Journal of Viral Hepatitis, vol. 24, pp. 37 - 42, http://dx.doi.org/10.1111/jvh.12615
    Journal articles | 2017
    Associate Professor Rowena Anne Bull
    Rodrigo C; Walker MR; Leung P; Eltahla AA; Grebely J; Dore GJ; Applegate T; Page K; Dwivedi S; Bruneau J; Morris MD; Cox AL; Osburn W; Kim AY; Schinkel J; Shoukry NH; Lauer GM; Maher L; Hellard M; Prins M; Luciani F; Lloyd AR; Bull RA, 2017, 'Limited naturally occurring escape in broadly neutralizing antibody epitopes in hepatitis C glycoprotein E2 and constrained sequence usage in acute infection', Infection, Genetics and Evolution, vol. 49, pp. 88 - 96, http://dx.doi.org/10.1016/j.meegid.2017.01.006
    Journal articles | 2017
    Associate Professor Rowena Anne Bull
    Bartlett SR; Wertheim JO; Bull RA; Matthews GV; Lamoury FMJ; Scheffler K; Hellard M; Maher L; Dore GJ; Lloyd AR; Applegate TL; Grebely J, 2017, 'A molecular transmission network of recent hepatitis C infection in people with and without HIV: Implications for targeted treatment strategies', Journal of Viral Hepatitis, vol. 24, pp. 404 - 411, http://dx.doi.org/10.1111/jvh.12652
    Journal articles | 2017
    Associate Professor Rowena Anne Bull
    Leung P; Eltahla AA; Lloyd AR; Bull RA; Luciani F, 2017, 'Understanding the complex evolution of rapidly mutating viruses with deep sequencing: Beyond the analysis of viral diversity', Virus Research, vol. 239, pp. 43 - 54, http://dx.doi.org/10.1016/j.virusres.2016.10.014
    Journal articles | 2017
    Associate Professor Rowena Anne Bull
    Rodrigo C; Eltahla AA; Bull RA; Luciani F; Grebely J; Dore GJ; Applegate T; Page K; Bruneau J; Morris MD; Cox AL; Osburn W; Kim AY; Shoukry NH; Lauer GM; Maher L; Schinkel J; Prins M; Hellard M; Lloyd AR, 2017, 'Phylogenetic analysis of full-length, early infection, hepatitis C virus genomes among people with intravenous drug use: the InC3 Study', Journal of Viral Hepatitis, vol. 24, pp. 43 - 52, http://dx.doi.org/10.1111/jvh.12616
    Journal articles | 2017
    Associate Professor Rowena Anne Bull
    Eltahla AA; Leung P; Pirozyan MR; Rodrigo C; Grebely J; Applegate T; Maher L; Luciani F; Lloyd AR; Bull RA, 2017, 'Dynamic evolution of hepatitis C virus resistance-associated substitutions in the absence of antiviral treatment', Scientific Reports, vol. 7, http://dx.doi.org/10.1038/srep41719
    Journal articles | 2017
    Associate Professor Rowena Anne Bull
    Eyre NS; Johnson SM; Eltahla AA; Aloi M; Aloia AL; McDevitt CA; Bull RA; Beard MR, 2017, 'Genome-wide mutagenesis of dengue virus reveals plasticity of the NS1 protein and enables generation of infectious tagged reporter viruses', Journal of Virology, vol. 91, http://dx.doi.org/10.1128/JVI.01455-17
    Journal articles | 2017
    Associate Professor Rowena Anne Bull
    Bartlett SR; Grebely J; Eltahla AA; Reeves JD; Howe AYM; Miller V; Ceccherini-Silberstein F; Bull RA; Douglas MW; Dore GJ; Harrington P; Lloyd AR; Jacka B; Matthews GV; Wang GP; Pawlotsky J-M; Feld JJ; Schinkel J; Garcia F; Lennerstrand J; Applegate TL, 2017, 'Sequencing of Hepatitis C Virus for Detection of Resistance to Direct-Acting Antiviral Therapy: A Systematic Review', HEPATOLOGY COMMUNICATIONS, vol. 1, pp. 379 - 390, http://dx.doi.org/10.1002/hep4.1050
    Journal articles | 2017
    Associate Professor Rowena Anne Bull
    Eden JS; Chisholm RH; Bull RA; White PA; Holmes EC; Tanaka MM, 2017, 'Persistent infections in immunocompromised hosts are rarely sources of new pathogen variants', Virus Evolution, vol. 3, http://dx.doi.org/10.1093/ve/vex018
    Journal articles | 2017
    Associate Professor Rowena Anne Bull
    Bartlett SR; Applegate T; Jacka B; Lamoury F; Bull R; Danta M; Bradshaw D; Lloyd AR; Hellard M; Dore GJ; Matthews GV; Grebely J, 2017, 'P6 Phylogenetic clustering of recent hepatitis C virus infection between 2004 and 2015', Journal of Virus Eradication, vol. 3, pp. 14 - 15, http://dx.doi.org/10.1016/s2055-6640(20)30747-0
    Journal articles | 2017
    Associate Professor Rowena Anne Bull
    Rizzetto S; Eltahla A; Lin P; Bull R; Lloyd A; Ho J; Venturi V; Luciani F, 2017, 'Impact of sequencing depth and read length on single cell RNA sequencing data: lessons from T cells', , http://dx.doi.org/10.1101/134130
    Journal articles | 2016
    Associate Professor Rowena Anne Bull
    Keoshkerian E; Hunter M; Cameron B; Nguyen N; Sugden P; Bull R; Zekry A; Maher L; Seddiki N; Zaunders J; Kelleher A; Lloyd AR; Dolan K; Haber P; Rawlinson W; Treloar C; Dore G; Luciani F, 2016, 'Hepatitis C-specific effector and regulatory CD4 T-cell responses are associated with the outcomes of primary infection', Journal of Viral Hepatitis, vol. 23, pp. 985 - 993, http://dx.doi.org/10.1111/jvh.12576
    Journal articles | 2016
    Associate Professor Rowena Anne Bull
    Eltahla AA; Rizzetto S; Pirozyan MR; Betz-Stablein BD; Venturi V; Kedzierska K; Lloyd AR; Bull RA; Luciani F, 2016, 'Linking the T cell receptor to the single cell transcriptome in antigen-specific human T cells', Immunology and Cell Biology, vol. 94, pp. 604 - 611, http://dx.doi.org/10.1038/icb.2016.16
    Journal articles | 2016
    Associate Professor Rowena Anne Bull
    Bull RA; Eltahla AA; Rodrigo C; Koekkoek SM; Walker M; Pirozyan MR; Betz-Stablein B; Toepfer A; Laird M; Oh S; Heiner C; Maher L; Schinkel J; Lloyd AR; Luciani F, 2016, 'A method for near full-length amplification and sequencing for six hepatitis C virus genotypes', BMC Genomics, vol. 17, http://dx.doi.org/10.1186/s12864-016-2575-8
    Journal articles | 2016
    Associate Professor Rowena Anne Bull
    Rodrigo C; Eltahla AA; Bull RA; Grebely J; Dore GJ; Applegate T; Page K; Bruneau J; Morris MD; Cox AL; Osburn W; Kim AY; Schinkel J; Shoukry NH; Lauer GM; Maher L; Hellard M; Prins M; Estes C; Razavi H; Lloyd AR; Luciani F, 2016, 'Historical Trends in the Hepatitis C Virus Epidemics in North America and Australia', Journal of Infectious Diseases, vol. 214, pp. 1383 - 1389, http://dx.doi.org/10.1093/infdis/jiw389
    Journal articles | 2016
    Associate Professor Rowena Anne Bull
    Walker MR; Li H; Teutsch S; Betz-Stablein B; Luciani F; Lloyd AR; Bull RA, 2016, 'Incident hepatitis c virus genotype distribution and multiple infection in australian prisons', Journal of Clinical Microbiology, vol. 54, pp. 1855 - 1861, http://dx.doi.org/10.1128/JCM.00287-16
    Journal articles | 2016
    Associate Professor Rowena Anne Bull
    Bartlett SR; Jacka B; Bull RA; Luciani F; Matthews GV; Lamoury FMJ; Hellard ME; Hajarizadeh B; Teutsch S; White B; Maher L; Dore GJ; Lloyd AR; Grebely J; Applegate TL, 2016, 'HIV infection and hepatitis C virus genotype 1a are associated with phylogenetic clustering among people with recently acquired hepatitis C virus infection', Infection, Genetics and Evolution, vol. 37, pp. 252 - 258, http://dx.doi.org/10.1016/j.meegid.2015.11.028
    Journal articles | 2015
    Associate Professor Rowena Anne Bull
    Bull RA; Leung P; Gaudieri S; Deshpande P; Cameron B; Walker M; Chopra A; Lloyd AR; Luciani F; Dolan K; Haber P; Rawlinson W; Treloar C; Dore G; Maher L, 2015, 'Transmitted/founder viruses rapidly escape from CD8+ T cell responses in acute hepatitis C virus infection', Journal of Virology, vol. 89, pp. 5478 - 5490, http://dx.doi.org/10.1128/JVI.03717-14
    Journal articles | 2015
    Associate Professor Rowena Anne Bull
    Mina MM; Luciani F; Cameron B; Bull RA; Beard MR; Booth D; Lloyd AR, 2015, 'Resistance to hepatitis C virus: Potential genetic and immunological determinants', The Lancet Infectious Diseases, vol. 15, pp. 451 - 460, http://dx.doi.org/10.1016/S1473-3099(14)70965-X
    Journal articles | 2015
    Associate Professor Rowena Anne Bull
    Lamoury FMJ; Jacka B; Bartlett S; Bull RA; Wong A; Amin J; Schinkel J; Poon AF; Matthews GV; Grebely J; Dore GJ; Applegate TL, 2015, 'The influence of hepatitis C virus genetic region on phylogenetic clustering analysis', PLoS ONE, vol. 10, http://dx.doi.org/10.1371/journal.pone.0131437
    Journal articles | 2015
    Associate Professor Rowena Anne Bull
    Narayana SK; Helbig KJ; McCartney EM; Eyre NS; Bull RA; Eltahla A; Lloyd AR; Beard MR, 2015, 'The interferon-induced transmembrane proteins, IFITM1, IFITM2, and IFITM3 inhibit hepatitis C virus entry', Journal of Biological Chemistry, vol. 290, pp. 25946 - 25959, http://dx.doi.org/10.1074/jbc.M115.657346
    Journal articles | 2015
    Associate Professor Rowena Anne Bull
    Eltahla AA; Luciani F; White PA; Lloyd AR; Bull RA, 2015, 'Inhibitors of the hepatitis C virus polymerase; mode of action and resistance', Viruses, vol. 7, pp. 5206 - 5224, http://dx.doi.org/10.3390/v7102868
    Journal articles | 2015
    Associate Professor Rowena Anne Bull
    Bretaña N; Boelen L; Bull R; Teutsch S; White P; Lloyd A; Luciani F, 2015, 'Transmission of Hepatitis C Virus among Prisoners, Australia, 2005–2012.', Emerging Infectious Diseases, vol. 21, pp. 765 - 774, http://dx.doi.org/10.3201/eid2105.141832
    Journal articles | 2014
    Associate Professor Rowena Anne Bull
    Töpfer A; Marschall T; Bull RA; Luciani F; Schönhuth A; Beerenwinkel N, 2014, 'Viral quasispecies assembly via maximal clique enumeration', Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), vol. 8394 LNBI, pp. 309 - 310, http://dx.doi.org/10.1007/978-3-319-05269-4-25
    Journal articles | 2014
    Associate Professor Rowena Anne Bull
    Hartfield M; Bull R; White PA; Lloyd A; Luciani F; Alizon S, 2014, 'Evidence that hepatitis C virus genome partly controls infection outcome', Evolutionary Applications, vol. 7, pp. 533 - 547, http://dx.doi.org/10.1111/eva.12151
    Journal articles | 2014
    Associate Professor Rowena Anne Bull
    Leung P; Bull R; Lloyd A; Luciani F, 2014, 'A bioinformatics pipeline for the analyses of viral escape dynamics and host immune responses during an infection', BioMed Research International, vol. 2014, pp. 1 - 12, http://dx.doi.org/10.1155/2014/264519
    Journal articles | 2014
    Associate Professor Rowena Anne Bull
    Leung P; Bull R; Lloyd A; Luciani F, 2014, 'Erratum: "A bioinformatics pipeline for the analyses of viral escape dynamics and host immune responses during an infection" (BioMed Research International)', BioMed Research International, vol. 2014, http://dx.doi.org/10.1155/2014/680249
    Journal articles | 2014
    Associate Professor Rowena Anne Bull
    Leung P; Bull R; Lloyd A; Luciani F, 2014, 'Erratum to “A Bioinformatics Pipeline for the Analyses of Viral Escape Dynamics and Host Immune Responses during an Infection”.', BioMed Research International, vol. 2014, http://dx.doi.org/10.1155/2014/680249
    Journal articles | 2013
    Associate Professor Rowena Anne Bull
    Wong KKY; Rockman SP; Wong C; Bull RA; Stelzer-Braid S; Rawlinson WD, 2013, 'Comparison of influenza virus replication fidelity in vitro using selection pressure with monoclonal antibodies', Journal of Medical Virology, vol. 85, pp. 1090 - 1094, http://dx.doi.org/10.1002/jmv.23532
    Journal articles | 2013
    Associate Professor Rowena Anne Bull
    Sugden PB; Pham TN; Ratnarajah S; Cameron B; Bull R; White PA; Michalak TI; Lloyd AR, 2013, 'Rare occurrence of occult hepatitis C virus in apparently uninfected injecting drug users: a two-centre, masked, case-control study', J Viral Hepat, vol. 20, pp. 725 - 728, http://dx.doi.org/10.1111/jvh.12098
    Journal articles | 2012
    Associate Professor Rowena Anne Bull
    Luciani F; Bull RA; Lloyd AR; Bull , 2012, 'Next generation deep sequencing and vaccine design: Today and tomorrow', Trends in Biotechnology, vol. 30, pp. 443 - 452, http://dx.doi.org/10.1016/j.tibtech.2012.05.005
    Journal articles | 2012
    Associate Professor Rowena Anne Bull
    Bull RA; Eden J-S; Luciani F; McElroy K; Rawlinson WD; White PA, 2012, 'Contribution of intra- and interhost dynamics to norovirus evolution', Journal of Virology, vol. 86, pp. 3219 - 3229, http://dx.doi.org/10.1128/JVI.06712-11
    Journal articles | 2012
    Associate Professor Rowena Anne Bull
    Gouklani H; Bull RA; Beyer C; Coulibaly F; Gowens E; Drummer H; Netter H; White PA; Haqshenas G, 2012, 'Hepatitis C virus nonstructural protein 5B is involved in virus morphogenesis', Journal of Virology, vol. 86, pp. 5080 - 5088, http://dx.doi.org/10.1128/JVI.07089-11
    Journal articles | 2012
    Associate Professor Rowena Anne Bull
    Sugden PB; Cameron B; Bull RA; White PA; Lloyd AR, 2012, 'Occult infection with hepatitis C virus: friend or foe?', Immunology and Cell Biology, vol. 90, pp. 763 - 773, http://dx.doi.org/10.1038/icb.2012.20
    Journal articles | 2012
    Associate Professor Rowena Anne Bull
    Grebely J; Pham ST; Matthews G; Petoumenos K; Bull RA; Yeung B; Rawlinson WD; Kaldor JM; Lloyd AR; Hellard M; Dore GJ; White PA; Bull , 2012, 'Hepatitis C virus reinfection and superinfection among treated and untreated participants with recent infection', Hepatology, vol. 55, pp. 1058 - 1069, http://dx.doi.org/10.1002/hep.24754
    Journal articles | 2011
    Associate Professor Rowena Anne Bull
    Bull RA; Luciani F; McElroy K; Gaudieri S; Pham ST; Chopra A; Cameron B; Maher L; Dore GJ; White PA; Lloyd AR, 2011, 'Sequential Bottlenecks Drive Viral Evolution in Early Acute Hepatitis C Virus Infection', PLoS Pathog, vol. 7, pp. e1002243, http://dx.doi.org/10.1371/journal.ppat.1002243
    Journal articles | 2011
    Associate Professor Rowena Anne Bull
    Bull RA; White PA, 2011, 'Mechanisms of GII.4 norovirus evolution', Trends in Microbiology, vol. 19, pp. 233 - 240, http://dx.doi.org/10.1016/j.tim.2011.01.002
    Journal articles | 2011
    Associate Professor Rowena Anne Bull
    Bull RA; Hyde J; MacKenzie J; Hansman G; Oka T; Takeda N; White PA, 2011, 'Comparison of the replication properties of murine and human calicivirus RNA-dependent RNA polymerases', Virus Genes, vol. 42, pp. 16 - 27, http://dx.doi.org/10.1007/s11262-010-0535-y
    Journal articles | 2011
    Associate Professor Rowena Anne Bull
    Wong K; Bull RA; Stelzer-Braid S; Fennell M; Rawlinson WD, 2011, 'Effect of reassortment on the nucleotide and amino acid changes of human A/H3N2 RNP subunits during 1998-2009', Journal of Clinical Virology, vol. 51, pp. 266 - 271, http://dx.doi.org/10.1016/j.jcv.2011.05.013
    Journal articles | 2011
    Associate Professor Rowena Anne Bull
    Wong KKY; Bull RA; Stelzer-Braid S; Fennell M; Rawlinson W, 2011, 'Effect of reassortment on the nucleotide and amino acid changes of human A/H3N2 RNP subunits during 1998-2009.', Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, vol. 51, pp. 270 - 275
    Journal articles | 2010
    Associate Professor Rowena Anne Bull
    Bull RA; Eden J-S; Rawlinson WD; White PA, 2010, 'Rapid Evolution of Pandemic Noroviruses of the GII.4 lineage', PLoS Pathogens, vol. 6, pp. e1000831 - e1000831, http://dx.doi.org/10.1371/journal.ppat.1000831
    Journal articles | 2010
    Associate Professor Rowena Anne Bull
    Eden J-S; Bull RA; Tu ET; McIver CJ; Michael JL; John AM; David WS; Jennie M; Rawlinson WD; White PA, 2010, 'Norovirus GII.4 variant 2006b caused epidemics of acute gastroenteritis in Australia during 2007 and 2008', Journal of Clinical Virology, vol. 49, pp. 265 - 271, http://dx.doi.org/10.1016/j.jcv.2010.09.001
    Journal articles | 2010
    Associate Professor Rowena Anne Bull
    Pham STP; Bull RA; Bennett JM; Rawlinson WD; Lloyd AR; Dore GJD; White PA; Bull , 2010, 'Frequent multiple hepatitis C virus infections among injection drug users in a prison setting', Hepatology, vol. 52, pp. 1564 - 1572, http://dx.doi.org/10.1002/hep.23885
    Journal articles | 2010
    Associate Professor Rowena Anne Bull
    Bull RA; Eden J-S; Rawlinson WD; White PA, 2010, 'Correction: Rapid Evolution of Pandemic Noroviruses of the GII.4 Lineage', PLoS Pathogens, vol. 6, http://dx.doi.org/10.1371/annotation/19042899-9f1b-4ccc-b13e-2a8faf19421b
    Journal articles | 2010
    Associate Professor Rowena Anne Bull
    Byun R; Sheppeard V; Bull R, 2010, 'Bug breakfast in the Bulletin: Gastroenteritis outbreaks in institutions.', New South Wales public health bulletin, vol. 21, pp. 267 - 268, http://dx.doi.org/10.1071/nb09038
    Journal articles | 2008
    Associate Professor Rowena Anne Bull
    Tu ET; Bull RA; Kim M; Mciver CJ; Heron LG; Rawlinson WD; White PA, 2008, 'Norovirus excretion in an aged-care setting', Journal of Clinical Microbiology, vol. 46, pp. 2119 - 2121, http://dx.doi.org/10.1128/JCM.02198-07
    Journal articles | 2008
    Associate Professor Rowena Anne Bull
    Tu ET; Bull RA; Greening G; Hewitt JE; Lyon M; Marshall J; Rawlinson WD; White PA, 2008, 'Epidemics of gastroenteritis during 2006 were associated with the spread of norovirus GII.4 variants 2006a and 2006b', Clinical Infectious Diseases, vol. 46, pp. 413 - 420, http://dx.doi.org/10.1086/525259
    Journal articles | 2007
    Associate Professor Rowena Anne Bull
    Tu ET; Nguyen TV; Lee PJ; Bull RA; Musto JA; Hansman G; White PA; Rawlinson WD; Mciver CJ, 2007, 'Norovirus GII.4 strains and outbreaks, Australia', Emerging Infectious Diseases, vol. 13, pp. 1128 - 1130, http://dx.doi.org/10.3201/eid1307.060999
    Journal articles | 2007
    Associate Professor Rowena Anne Bull
    Bull RA; Tanaka M; White PA, 2007, 'Norovirus recombination', Journal of General Virology, vol. 88, pp. 3347 - 3359, http://dx.doi.org/10.1099/vir.0.83321-0
    Journal articles | 2006
    Associate Professor Rowena Anne Bull
    Bull RA; Tu ET; Mciver CJ; Rawlinson WD; White PA, 2006, 'Emergence of a new norovirus genotype II.4 variant associated with global outbreaks of gastroenteritis', Journal of Clinical Microbiology, vol. 44, pp. 327 - 333, http://dx.doi.org/10.1128/JCM.44.2.327-333.2006
    Journal articles | 2005
    Associate Professor Rowena Anne Bull
    Bull RA; Hansman G; Clancy LE; Tanaka M; Rawlinson WD; White PA, 2005, 'Norovirus recombination in ORF1/ORF2 overlap', Emerging Infectious Diseases, vol. 11, pp. 1079 - 1085, http://dx.doi.org/10.3201/eid1107.041273
    Journal articles |
    Associate Professor Rowena Anne Bull
    Capraro A; Wong SL; Adhikari A; Allan KM; Patel HR; Zhong L; Raftery M; Jaffe A; Yeang M; Aggarwal A; Wu L; Pandzic E; Whan RM; Turville S; Vittorio O; Bull RA; Kaakoush N; Rawlinson WD; Tedla N; Vafaee F; Waters SA, 'Ageing impairs the airway epithelium defence response to SARS-CoV-2', , http://dx.doi.org/10.1101/2021.04.05.437453
  • Conference Abstracts | 2020
    Associate Professor Rowena Anne Bull
    Brasher NA; Eltahla AA; Underwood A; Tedla N; Lloyd AR; Bull RA, 2020, 'B cell immunodominance in primary hepatitis C virus infection', in JOURNAL OF HEPATOLOGY, ELSEVIER, Vol. 72, pp. E38 - E38, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000520050900030&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2017
    Associate Professor Rowena Anne Bull
    Bartlett SR; Grebely J; Eltahla AA; Reeves JD; Howe A; Miller V; Bull RA; Ceccherini-Silberstein F; Douglas MW; Dore GJ; Harrington P; Lloyd AR; Jacka B; Matthews GV; Wang GP; Pawlotsky J-M; Feld JJ; Schinkel J; Garcia F; Lennerstrand J; Applegate TL, 2017, 'Systematic review & expert guidance on methods for sequencing of hepatitis C virus for detection of direct-acting antiviral resistance', in JOURNAL OF HEPATOLOGY, ELSEVIER SCIENCE BV, Amsterdam, NETHERLANDS, Vol. 66, pp. S323 - S323, presented at International Liver Congress / 52nd Annual Meeting of the European-Association-for-the-Study-of-the-Liver, Amsterdam, NETHERLANDS, 19 April 2017 - 23 April 2017, http://dx.doi.org/10.1016/S0168-8278(17)30970-4
    Conference Papers | 2017
    Associate Professor Rowena Anne Bull
    Horton JL; Kim KW; Pang CN; Jain K; Leung P; Isaacs SR; Bull RA; Luciani F; Wilkins MR; Lipkin WI; Rawlinson WD; Briese T; Craig ME, 2017, 'Virome-Capture Sequencing of the Gut and Plasma Virome in Children with Islet Autoimmunity', in DIABETES, AMER DIABETES ASSOC, pp. LB51 - LB52, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000463087200190&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2015
    Associate Professor Rowena Anne Bull
    Leung P; Bull R; Lloyd A; Luciani F, 2015, 'Co-evolving mutations in hepatitis C virus in the context of immune escape against neutralising antibody responses - A bioinformatic workflow for the analysis of co-evolving mutations in viral genomes', in International Workshop on Artificial Immune Systems, AIS 2015/ICSI3 2015 - Systems Immunology, Immunoinformatics and Immune-computation: Immunology without Borders, Proceedings, Sicily, Italy, presented at 2015 International Workshop on Artificial Immune Systems (AIS), Sicily, Italy, 17 July 2015 - 18 July 2015, http://dx.doi.org/10.1109/AISW.2015.7469236
    Conference Papers | 2014
    Associate Professor Rowena Anne Bull
    Töpfer A; Marschall T; Bull RA; Luciani F; Schönhuth A; Beerenwinkel N, 2014, 'Viral quasispecies assembly via maximal clique enumeration', in Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), pp. 309 - 310, http://dx.doi.org/10.1007/978-3-319-05269-4_25
    Conference Papers | 2013
    Associate Professor Rowena Anne Bull
    Boelen L; Bull RA; Teutsch S; Lloyd AR; Luciani F, 2013, 'MOLECULAR EPIDEMIOLOGY AND SOCIAL NETWORK ANALYSIS TO TRACK HCV TRANSMISSION IN HIGH-RISK COMMUNITIES: INJECTING DRUG USERS IN PRISONS OF NEW SOUTH WALES, AUSTRALIA', in JOURNAL OF HEPATOLOGY, ELSEVIER SCIENCE BV, Amsterdam, NETHERLANDS, pp. S193 - S193, presented at International Liver Congress / 48th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL), Amsterdam, NETHERLANDS, 24 April 2013 - 28 April 2013, http://dx.doi.org/10.1016/S0168-8278(13)60473-0
    Conference Papers | 2012
    Associate Professor Rowena Anne Bull
    Luciani F; Bull RA; Cameron B; Gaudieri S; Nguyen N; Yuen D; White PA; Purcell DFJ; Foung S; Lloyd AR, 2012, 'IMMUNE RESPONSES AGAINST FOUNDER HEPATITIS C VIRUSES IN ACUTE ASYMPTOMATIC SUBJECTS', in JOURNAL OF HEPATOLOGY, ELSEVIER SCIENCE BV, Barcelona, SPAIN, pp. S312 - S312, presented at 47th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL), Barcelona, SPAIN, 18 April 2012 - 22 April 2012, http://dx.doi.org/10.1016/S0168-8278(12)60809-5
    Conference Papers | 2011
    Associate Professor Rowena Anne Bull
    Luciani F; Bull R; Mcelroy K; Pham S; Cameron B; Chopra A; Gaudieri S; Cooper D; Lloyd A; White P, 2011, 'EVOLUTIONARY DYNAMICS OF HEPATITIS C VIRUS DURING VERY EARLY INFECTIONS: VIROLOGICAL AND IMMUNOLOGICAL INSIGHTS', in JOURNAL OF HEPATOLOGY, ELSEVIER, Berlin, GERMANY, pp. S18 - S18, presented at 46th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL), Berlin, GERMANY, 30 March 2011 - 03 April 2011, http://dx.doi.org/10.1016/S0168-8278(11)60040-8
    Theses / Dissertations | 2008
    Associate Professor Rowena Anne Bull
    Bull RA, 2008, Mechanisms of replication and genomic diversity in Human Caliciviruses

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