Professor Samuel Norbert Breit
Conjoint Professor

Professor Samuel Norbert Breit

MBBS, MD, FRACP, FRCPA

medicine-health
St Vincent's Clinical School

Prof Breit is a Clinical Immunologist and Immunopathologist at St Vincent’s Hospital Sydney. As a Professor of Medicine at UNSW, he heads the Inflammation and Cytokine Biology Research Program at St Vincent’s Centre of Applied Medical Research. He has a career long interest in biomedical research,  has a long track record of project grant support and has published over 160 papers in peer-reviewed journals. Prof Breit’s group has spearheaded the investigation of 2 important molecules his research group first discovered and characterised over a decade ago: the intracellular chloride ion channel protein CLIC1 and the divergent TGF-b superfamily cytokine MIC-1/GDF15. With the latter molecule, through an evolving understanding of its biology and potential clinical application, Prof Breit has then been able to take his basic discoveries, from the bench to the bedside. These discoveries have been licensed to several major international companies where they will be applied to patient diagnosis and therapy: MIC-1/GDF15 diagnostic technology can be used in the diagnosis and management of cancer and cardiovascular disease, whilst therapeutic applications include the treatment of inflammatory diseases, obesity and cancer associated syndromes.

Prof Breit collaborates widely and maintains an active research program, involving post-doctoral scientist and PhD students, directed to understanding the biology, mode of action, disease association and therapeutic application of MIC-1/GDF15 and its receptor GFRAL. Currently his research is focused on understanding the central and peripheral mechanisms by which MIC-1/GDF15 causes anorexia, modulates metabolism and impacts inflammation and immunity

Prof Breit's publications and metrics can be found on https://scholar.google.com/citations?user=ouBIM90AAAAJ&hl=en

Phone
+61-2-8382-4952
Location
St Vincent's Hospital Sydney campus Level 8, Lowy Packer Building, 405 Liverpool St, Darlinghurst

Publications

  • Book Chapters | 2016
    Professor Samuel Norbert Breit
    Breit SN; Brown DA, 2016, 'TGF beta Superfamily Cytokine MIC-1/GDF15 in Health and Inflammatory Diseases', in Compendium of Inflammatory Diseases, Springer Basel, pp. 1236 - 1245, http://dx.doi.org/10.1007/978-3-7643-8550-7_54
    Book Chapters | 2014
    Professor Samuel Norbert Breit
    Breit SN; Brown DA, 2014, 'TGF-b Superfamily Cytokine MIC-1/GDF15 in Health and Inflammatory Diseases', in Encyclopedia of Inflammatory Diseases, Springer Basel, pp. 1 - 13, http://dx.doi.org/10.1007/978-3-0348-0620-6_54-1
    Book Chapters | 2014
    Professor Samuel Norbert Breit
    Brown DA; Bauskin AR; Breit SN, 2014, 'MIC-1', in Encyclopedia of Cancer, Springer Berlin Heidelberg, pp. 1 - 6, http://dx.doi.org/10.1007/978-3-642-27841-9_3704-2
    Book Chapters | 2014
    Professor Samuel Norbert Breit
    Brown DA; Bauskin AR; Breit SN, 2014, 'MIC-1', in Encyclopedia of Cancer, Springer Berlin Heidelberg, pp. 2816 - 2821, http://dx.doi.org/10.1007/978-3-662-46875-3_3704
    Book Chapters | 2011
    Professor Samuel Norbert Breit
    Brown DA; Breit SN; Bauskin AR, 2011, 'MIC-1', in Encyclopedia of Cancer, Springer Berlin Heidelberg, pp. 2285 - 2289, http://dx.doi.org/10.1007/978-3-642-16483-5_3704
    Book Chapters | 2001
    Professor Samuel Norbert Breit
    Moore AG; Fairlie WD; Bauskin AR; Brown PK; Russell PK; Zhang H-P; Breit SN, 2001, 'MIC-1 and other TGF-β superfamily members in inflammation', in TGF-β and Related Cytokines in Inflammation, Birkhäuser Basel, pp. 1 - 9, http://dx.doi.org/10.1007/978-3-0348-8354-2_1
    Book Chapters | 1997
    Professor Samuel Norbert Breit
    Breit SN; Penny R, 1997, 'Scleroderma: Clinical features and pathogenesis', in Clinical Immunology, edn. Original, Academic Press Inc Elsevier Science, San Diego, Ca, USA, pp. 346 - 356
    Book Chapters | 1996
    Professor Samuel Norbert Breit
    Conaghan PG; Breit SN, 1996, 'The pathogenesis of pulmonary manifestations of connective tissue diseases', in Lung Immunopathology, edn. Original, Butterworth Heinemann Press, Boston, USA, pp. 147 - 164
    Book Chapters |
    Professor Samuel Norbert Breit
    Bauskin AR; Brown DA; Breit SN, 'MIC-1', in Encyclopedia of Cancer, Springer Berlin Heidelberg, pp. 1870 - 1873, http://dx.doi.org/10.1007/978-3-540-47648-1_3704
  • Journal articles | 2021
    Professor Samuel Norbert Breit
    Trend S; Leffler J; Jones AP; Cha L; Gorman S; Brown DA; Breit SN; Kermode AG; French MA; Ward NC; Hart PH, 2021, 'Associations of serum short-chain fatty acids with circulating immune cells and serum biomarkers in patients with multiple sclerosis', Scientific Reports, vol. 11, pp. 5244, http://dx.doi.org/10.1038/s41598-021-84881-8
    Journal articles | 2021
    Professor Samuel Norbert Breit
    Breit SN; Brown DA; Tsai VWW, 2021, 'The GDF15-GFRAL Pathway in Health and Metabolic Disease: Friend or Foe?', Annual Review of Physiology, vol. 83, pp. 127 - 151, http://dx.doi.org/10.1146/annurev-physiol-022020-045449
    Journal articles | 2020
    Professor Samuel Norbert Breit
    Husaini Y; Tsai VWW; Manandhar R; Zhang HP; Lee-Ng KKM; Lebhar H; Marquis CP; Brown DA; Breit SN, 2020, 'Growth differentiation factor-15 slows the growth of murine prostate cancer by stimulating tumor immunity', PLoS ONE, vol. 15, pp. e0233846, http://dx.doi.org/10.1371/journal.pone.0233846
    Journal articles | 2020
    Professor Samuel Norbert Breit
    Kelleher A; Breit S; Levy JA, 2020, 'Professor Ronald Penny IN MEMORIAM', AIDS, vol. 34, pp. 959 - 960, http://dx.doi.org/10.1097/QAD.0000000000002520
    Journal articles | 2020
    Professor Samuel Norbert Breit
    Breit S; Ziegler J; Kelleher AD, 2020, 'Vale Ron Penny AO (1936-2019): pioneer of clinical immunology OBITUARY', CLINICAL & TRANSLATIONAL IMMUNOLOGY, vol. 9, http://dx.doi.org/10.1002/cti2.1119
    Journal articles | 2019
    Professor Samuel Norbert Breit
    Hassanpour Golakani M; Mohammad MG; Li H; Gamble J; Breit SN; Ruitenberg MJ; Brown DA, 2019, 'MIC-1/GDF15 Overexpression Is Associated with Increased Functional Recovery in Traumatic Spinal Cord Injury', Journal of Neurotrauma, vol. 36, pp. 3410 - 3421, http://dx.doi.org/10.1089/neu.2019.6421
    Journal articles | 2019
    Professor Samuel Norbert Breit
    Tsai VWW; Zhang HP; Manandhar R; Schofield P; Christ D; Lee-Ng KKM; Lebhar H; Marquis CP; Husaini Y; Brown DA; Breit SN, 2019, 'GDF15 mediates adiposity resistance through actions on GFRAL neurons in the hindbrain AP/NTS', International Journal of Obesity, vol. 43, pp. 2370 - 2380, http://dx.doi.org/10.1038/s41366-019-0365-5
    Journal articles | 2018
    Professor Samuel Norbert Breit
    Tsai VWW; Husaini Y; Sainsbury A; Brown DA; Breit SN, 2018, 'The MIC-1/GDF15-GFRAL Pathway in Energy Homeostasis: Implications for Obesity, Cachexia, and Other Associated Diseases', Cell Metabolism, vol. 28, pp. 353 - 368, http://dx.doi.org/10.1016/j.cmet.2018.07.018
    Journal articles | 2018
    Professor Samuel Norbert Breit
    Tsai VW; Zhang HP; Manandhar R; Lee-Ng KKM; Lebhar H; Marquis CP; Husaini Y; Sainsbury A; Brown DA; Breit SN, 2018, 'Treatment with the TGF-b superfamily cytokine MIC-1/GDF15 reduces the adiposity and corrects the metabolic dysfunction of mice with diet-induced obesity', International Journal of Obesity, vol. 42, pp. 561 - 571, http://dx.doi.org/10.1038/ijo.2017.258
    Journal articles | 2018
    Professor Samuel Norbert Breit
    Jiang J; Thalamuthu A; Ho JE; Mahajan A; Ek WE; Brown DA; Breit SN; Wang TJ; Gyllensten U; Chen MH; Enroth S; Januzzi JL; Lind L; Armstrong NJ; Kwok JB; Schofield PR; Wen W; Trollor JN; Johansson Å; Morris AP; Vasan RS; Sachdev PS; Mather KA, 2018, 'A meta-analysis of genome-wide association studies of growth differentiation factor-15 concentration in blood', Frontiers in Genetics, vol. 9, http://dx.doi.org/10.3389/fgene.2018.00097
    Journal articles | 2018
    Professor Samuel Norbert Breit
    Tsai VWW; Brown DA; Breit SN, 2018, 'Targeting the divergent TGFβ superfamily cytokine MIC-1/GDF15 for therapy of anorexia/cachexia syndromes', Current opinion in supportive and palliative care, vol. 12, pp. 404 - 409, http://dx.doi.org/10.1097/SPC.0000000000000384
    Journal articles | 2017
    Professor Samuel Norbert Breit
    Borner T; Arnold M; Ruud J; Breit SN; Langhans W; Lutz TA; Blomqvist A; Riediger T, 2017, 'Anorexia-cachexia syndrome in hepatoma tumour-bearing rats requires the area postrema but not vagal afferents and is paralleled by increased MIC-1/GDF15', Journal of Cachexia, Sarcopenia and Muscle, vol. 8, pp. 417 - 427, http://dx.doi.org/10.1002/jcsm.12169
    Journal articles | 2017
    Professor Samuel Norbert Breit
    Breit SN; Tsai VWW; Brown DA, 2017, 'Targeting Obesity and Cachexia: Identification of the GFRAL Receptor–MIC-1/GDF15 Pathway', Trends in Molecular Medicine, vol. 23, pp. 1065 - 1067, http://dx.doi.org/10.1016/j.molmed.2017.10.005
    Journal articles | 2017
    Professor Samuel Norbert Breit
    Low JK; Ambikairajah A; Shang K; Brown DA; Tsai VWW; Breit SN; Karl T, 2017, 'First behavioural characterisation of a knockout mouse model for the transforming growth factor (TGF)-β superfamily cytokine, MIC-1/GDF15', PLoS ONE, vol. 12, http://dx.doi.org/10.1371/journal.pone.0168416
    Journal articles | 2017
    Professor Samuel Norbert Breit
    Domingo-Fernández R; Coll RC; Kearney J; Breit S; O’Neill LAJ, 2017, 'The intracellular chloride channel proteins CLIC1 and CLIC4 induce IL-1β transcription and activate the NLRP3 inflammasome', Journal of Biological Chemistry, vol. 292, pp. 12077 - 12087, http://dx.doi.org/10.1074/jbc.M117.797126
    Journal articles | 2017
    Professor Samuel Norbert Breit
    Danta M; Barber DA; Zhang HP; Lee-Ng M; Baumgart SWL; Tsai VWW; Husaini Y; Saxena M; Marquis CP; Errington W; Kerr S; Breit SN; Brown DA, 2017, 'Macrophage inhibitory cytokine-1/growth differentiation factor-15 as a predictor of colonic neoplasia', Alimentary Pharmacology and Therapeutics, vol. 46, pp. 347 - 354, http://dx.doi.org/10.1111/apt.14156
    Journal articles | 2017
    Professor Samuel Norbert Breit
    Baumgart S; Barber DA; Zhang HP; Lee-Ng M; Breit S; Brown D; Danta M, 2017, 'Macrophage Inhibitory Cytokine 1 (MIC1/GDF15) as a Novel Serum Biomarker of Colonic Neoplasia', Gastroenterology, vol. 152, pp. S1030 - S1030, http://dx.doi.org/10.1016/s0016-5085(17)33483-2
    Journal articles | 2016
    Professor Samuel Norbert Breit
    Tsai VWW; Lin S; Brown DA; Salis A; Breit SN, 2016, 'Anorexia-cachexia and obesity treatment may be two sides of the same coin: Role of the TGF-b superfamily cytokine MIC-1/GDF15', International Journal of Obesity, vol. 40, pp. 193 - 197, http://dx.doi.org/10.1038/ijo.2015.242
    Journal articles | 2016
    Professor Samuel Norbert Breit
    Hare JE; Goodchild SC; Breit SN; Curmi PMG; Brown LJ, 2016, 'Interaction of Human Chloride Intracellular Channel Protein 1 (CLIC1) with Lipid Bilayers: A Fluorescence Study', Biochemistry, vol. 55, pp. 3825 - 3833, http://dx.doi.org/10.1021/acs.biochem.6b00080
    Journal articles | 2016
    Professor Samuel Norbert Breit
    Salao K; Jiang L; Li H; Tsai VWW; Husaini Y; Curmi PMG; Brown LJ; Brown DA; Breit SN, 2016, 'CLIC1 regulates dendritic cell antigen processing and presentation by modulating phagosome acidification and proteolysis', Biology Open, vol. 5, pp. 620 - 630, http://dx.doi.org/10.1242/bio.018119
    Journal articles | 2016
    Professor Samuel Norbert Breit
    Mahon KL; Lin H-M; Spielman C; Lee-Ng M; Gurney H; Mallesara G; Stockler MR; Briscoe KP; Marx GM; Breit SN; Brown DA; Horvath L, 2016, 'Phase II trial of circulating cytokines as markers of docetaxel (DTX) resistance in metastatic castrate-resistant prostate cancer (mCRPC).', Journal of Clinical Oncology, vol. 34, pp. 5039 - 5039, http://dx.doi.org/10.1200/jco.2016.34.15_suppl.5039
    Journal articles | 2015
    Professor Samuel Norbert Breit
    Mahon KL; Lin HM; Castillo L; Lee BY; Lee-Ng M; Chatfield MD; Chiam K; Breit SN; Brown DA; Molloy MP; Marx GM; Pavlakis N; Boyer MJ; Stockler MR; Daly RJ; Henshall SM; Horvath LG, 2015, 'Cytokine profiling of docetaxel-resistant castration-resistant prostate cancer', British Journal of Cancer, vol. 112, pp. 1340 - 1348, http://dx.doi.org/10.1038/bjc.2015.74
    Journal articles | 2015
    Professor Samuel Norbert Breit
    Fisher OM; Levert-Mignon AJ; Lord SJ; Lee-Ng KKM; Botelho NK; Falkenback D; Thomas ML; Bobryshev YV; Whiteman DC; Brown DA; Breit SN; Lord RV, 2015, 'MIC-1/GDF15 in Barrett's oesophagus and oesophageal adenocarcinoma', British Journal of Cancer, vol. 112, pp. 1384 - 1391, http://dx.doi.org/10.1038/bjc.2015.100
    Journal articles | 2015
    Professor Samuel Norbert Breit
    Husaini Y; Lockwood GP; Nguyen TV; Tsai VWW; Mohammad MG; Russell PJ; Brown DA; Breit SN, 2015, 'Macrophage inhibitory cytokine-1 (MIC-1/GDF15) gene deletion promotes cancer growth in TRAMP prostate cancer prone mice', PLoS ONE, vol. 10, http://dx.doi.org/10.1371/journal.pone.0115189
    Journal articles | 2015
    Professor Samuel Norbert Breit
    Sasson SC; McGill K; Wienholt L; Carr A; Brown DA; Kelleher AD; Breit SN; Sewell WA, 2015, 'Comparison of the Freelite serum free light chain (SFLC) assay with serum and urine electrophoresis/immunofixation and the N Latex FLC assay', Pathology, vol. 47, pp. 564 - 569, http://dx.doi.org/10.1097/PAT.0000000000000316
    Journal articles | 2015
    Professor Samuel Norbert Breit
    Jiang J; Wen W; Brown DA; Crawford J; Thalamuthu A; Smith E; Breit SN; Liu T; Zhu W; Brodaty H; Baune BT; Trollor JN; Sachdev PS, 2015, 'The relationship of serum macrophage inhibitory cytokine - 1 levels with gray matter volumes in community-dwelling older individuals', PLoS ONE, vol. 10, pp. e0123399, http://dx.doi.org/10.1371/journal.pone.0123399
    Journal articles | 2015
    Professor Samuel Norbert Breit
    Jiang J; Trollor JN; Brown DA; Crawford JD; Thalamuthu A; Smith E; Breit SN; Liu T; Brodaty H; Baune BT; Sachdev PS; Wen W, 2015, 'An inverse relationship between serum macrophage inhibitory cytokine-1 levels and brain white matter integrity incommunity-dwelling older individuals', Psychoneuroendocrinology, vol. 62, pp. 80 - 88, http://dx.doi.org/10.1016/j.psyneuen.2015.07.610
    Journal articles | 2015
    Professor Samuel Norbert Breit
    Tsai VWW; Macia L; Feinle-Bisset C; Manandhar R; Astrup A; Raben A; Lorenzen JK; Schmidt PT; Wiklund F; Pedersen NL; Campbell L; Kriketos A; Xu A; Pengcheng Z; Jia W; Curmi PMG; Angstmann CN; Lee-Ng KKM; Zhang HP; Marquis CP; Husaini Y; Beglinger C; Lin S; Herzog H; Brown DA; Sainsbury A; Breit SN, 2015, 'Serum levels of human MIC-1/GDF15 vary in a diurnal pattern, do not display a profile suggestive of a satiety factor and are related to BMI', PLoS ONE, vol. 10, http://dx.doi.org/10.1371/journal.pone.0133362
    Journal articles | 2015
    Professor Samuel Norbert Breit
    Sasson SC; McGill K; Wienholt L; Carr A; Brown D; Kelleher AD; Breit SN; Sewell WA, 2015, 'Retrospective audit of the freeliteTM serum free light chain (SFLC) assay: testing patterns, concordance with serum and urine electrophoresis/immunofixation and correlation with the N latex FLC assay', Pathology, vol. 47, pp. S94 - S94, http://dx.doi.org/10.1097/01.pat.0000461601.28805.d5
    Journal articles | 2014
    Professor Samuel Norbert Breit
    Mohammad MG; Tsai VWW; Ruitenberg MJ; Hassanpour M; Li H; Hart PH; Breit SN; Sawchenko PE; Brown DA, 2014, 'Immune cell trafficking from the brain maintains CNS immune tolerance', Journal of Clinical Investigation, vol. 124, pp. 1228 - 1241, http://dx.doi.org/10.1172/JCI71544
    Journal articles | 2014
    Professor Samuel Norbert Breit
    Tsai VWW; Manandhar R; Jrøgensen SB; Lee-Ng KKM; Zhang HP; Marquis CP; Jiang L; Husaini Y; Lin S; Sainsbury A; Sawchenko PE; Brown DA; Breit SN, 2014, 'The anorectic actions of the TGFβ cytokine MIC-1/GDF15 require an intact brainstem area postrema and nucleus of the solitary tract', PLoS ONE, vol. 9, http://dx.doi.org/10.1371/journal.pone.0100370
    Journal articles | 2014
    Professor Samuel Norbert Breit
    Jiang L; Phang JM; Yu J; Harrop SJ; Sokolova AV; Duff AP; Wilk KE; Alkhamici H; Breit SN; Valenzuela SM; Brown LJ; Curmi PMG, 2014, 'CLIC proteins, ezrin, radixin, moesin and the coupling of membranes to the actin cytoskeleton: A smoking gun?', Biochimica et Biophysica Acta - Biomembranes, vol. 1838, pp. 643 - 657, http://dx.doi.org/10.1016/j.bbamem.2013.05.025
    Journal articles | 2014
    Professor Samuel Norbert Breit
    Mohammad MG; Tsai VWW; Ruitenberg MJ; Hassanpour M; Li H; Hart PH; Breit SN; Sawchenko PE; Brown DA, 2014, 'A forebrain-immune cell pathway for the maintenance of CNS immune tolerance', Neurology, Psychiatry and Brain Research, vol. 20, pp. 8 - 9, http://dx.doi.org/10.1016/j.npbr.2014.01.144
    Journal articles | 2014
    Professor Samuel Norbert Breit
    Tsai VW-W; Macia L; Manandhar R; Wiklund F; Grönberg H; Pedersen N; Lee-Ng M; Zhang HP; Brown D; Herzog H; Sainsbury A; Breit SN, 2014, 'Macrophage inhibitory cytokine 1 (MIC-1/GDF15), a novel regulator of body weight and appetite and a potential therapeutic for obesity', Obesity Research & Clinical Practice, vol. 8, pp. 105 - 105, http://dx.doi.org/10.1016/j.orcp.2014.10.191
    Journal articles | 2014
    Professor Samuel Norbert Breit
    Fuchs T; Trollor JN; Crawford J; Baune BT; Samaras K; Campbell L; Breit SN; Brodaty H; Sachdev P; Smith E; Brown DA, 2014, 'Macrophage inhibitory cytokine-1 is associated with cognitive impairment and predicts cognitive decline – The Sydney Memory and Aging Study', Neurology, Psychiatry and Brain Research, vol. 20, pp. 9 - 9, http://dx.doi.org/10.1016/j.npbr.2014.01.145
    Journal articles | 2013
    Professor Samuel Norbert Breit
    Mohammad MG; Hassanpour M; Tsai VW-W; Li H; Ruitenberg MJ; Booth D; Serrats J; Hart PH; Symonds GP; Sawchenko P; Breit SN; Brown DA, 2013, 'Dendritic cells and multiple sclerosis: Disease, tolerance and therapy', International Journal of Molecular Sciences, vol. 14, pp. 547 - 562, http://dx.doi.org/10.3390/ijms14010547
    Journal articles | 2013
    Professor Samuel Norbert Breit
    Tsai VW-W; Macia L; Johnen H; Kuffner T; Manadhar R; Jorgensen ; Lee-Ng KKM; Hong PZ; Wu L; Marquis C; Jiang L; Husaini Y; Lin S; Herzog H; Brown DA; Sainsbury-Salis A; Breit SN, 2013, 'TGF-b Superfamily Cytokine MIC-1/GDF15 Is a Physiological Appetite and Body Weight Regulator', PLoS ONE, vol. 8, pp. e55174, http://dx.doi.org/10.1371/journal.pone.0055174
    Journal articles | 2013
    Professor Samuel Norbert Breit
    Averaimo S; Abeti R; Savalli N; Brown LJ; Curmi PMG; Breit SN; Mazzanti M, 2013, 'Point Mutations in the Transmembrane Region of the Clic1 Ion Channel Selectively Modify Its Biophysical Properties', PLoS ONE, vol. 8, http://dx.doi.org/10.1371/journal.pone.0074523
    Journal articles | 2013
    Professor Samuel Norbert Breit
    Fuchs T; Trollor JN; Crawford J; Baune BT; Samaras K; Campbell L; Breit SN; Brodaty H; Sachdev P; Smith E, 2013, 'Macrophage inhibitory cytokine-1 is associated with cognitive impairment and predicts cognitive decline – the Sydney Memory and Ageing Study', Aging Cell, vol. 12, pp. 882 - 889, http://dx.doi.org/10.1111/acel.12116
    Journal articles | 2013
    Professor Samuel Norbert Breit
    Horvath L; Chatfield MD; Lee-Ng M; Lin H-M; Castillo L; Breit SN; Brown DA; Molloy MP; Marx GM; Pavlakis N; Boyer MJ; Stockler MR; Wykes R; Henshall SM; Mahon KL, 2013, 'The role of macrophages in docetaxel (DTX) resistance in castrate-resistant prostate cancer (CRPC).', Journal of Clinical Oncology, vol. 31, pp. e22175 - e22175, http://dx.doi.org/10.1200/jco.2013.31.15_suppl.e22175
    Journal articles | 2012
    Professor Samuel Norbert Breit
    Johnen H; Kuffner T; Brown DA; Wu L; Stocker R; Breit SN, 2012, 'Increased expression of the TGF-b superfamily cytokine MIC-1/GDF15 protects ApoE(-/-) mice from the development of atherosclerosis', Cardiovascular Pathology, vol. 21, pp. 499 - 505, http://dx.doi.org/10.1016/j.carpath.2012.02.003
    Journal articles | 2012
    Professor Samuel Norbert Breit
    Husaini Y; Qiu MR; Lockwood G; Luo X; Shang P; Kuffner T; Tsai VW-W; Lele J; Russell PJ; Brown DA; Breit SN, 2012, 'Macrophage inhibitory cytokine-1 (MIC-1/GDF15) slows cancer development but increases metastases in TRAMP prostate cancer prone mice', PLoS One, vol. 7, pp. e43833, http://dx.doi.org/10.1371/journal.pone.0043833
    Journal articles | 2012
    Professor Samuel Norbert Breit
    Macia L; Tsai VWW; Nguyen AD; Johnen H; Kuffner T; Shi Y; Lin S; Herzog H; Brown DA; Breit SN; Sainsbury-Salis A, 2012, 'Macrophage inhibitory cytokine 1 (MIC-1/GDF15) decreases food intake, body weight and improves glucose tolerance in mice on normal & obesogenic diets', PLoS One, vol. 7, pp. e34868, http://dx.doi.org/10.1371/journal.pone.0034868
    Journal articles | 2012
    Professor Samuel Norbert Breit
    Tsai VW-W; Husaini Y; Manandhar R; Lee-ng KKM; Hong PZ; Harriott K; Jiang L; Lin S; Sainsbury-Salis A; Brown DA; Breit SN, 2012, 'Anorexia/cachexia of chronic diseases: a role for the TGF-beta family cytokine MIC-1/GDF15', Journal of Cachexia, Sarcopenia and Muscle, vol. 3, pp. 239 - 243, http://dx.doi.org/10.1007/s13539-012-0082-6
    Journal articles | 2012
    Professor Samuel Norbert Breit
    Breit SN; Carrero JJ; Tsai VWW; Yagoutifam N; Luo XW; Kuffner T; Bauskin AR; Wu L; Jiang L; Baranyi P; Heimburer O; Murikami M; Apple F; Marquis C; Macia L; Lin S; Sainsbury-Salis A; Herzog H; Law MG; Stenvinkel P; Brown DA, 2012, 'Macrophage inhibitory cytokine-1 (MIC-1/GDF15) and mortality in end-stage renal disease', Nephrology Dialysis Transplantation, vol. 27, pp. 70 - 75, http://dx.doi.org/10.1093/ndt/gfr575
    Journal articles | 2012
    Professor Samuel Norbert Breit
    Jiang L; Salao K; Li H; Rybicka JM; Yates R; Luo X; Shi XX; Kuffner T; Tsai VW-W; Husaini Y; Wu L; Brown DA; Grewal T; Brown LJ; Curmi PM; Breit SN, 2012, 'Intracellular chloride channel protein CLIC1 regulates macrophage function through modulation of phagosomal acidification', Journal of Cell Science, vol. 125, pp. 5479 - 5488, http://dx.doi.org/10.1242/jcs.110072
    Journal articles | 2012
    Professor Samuel Norbert Breit
    Brown D; Hance KW; Rogers C; Sansbury ; Albert P; Murphy G; Laiyemo A; Wang Z; Cross A; Schatzkin A; Danta M; Srasu ; Amin J; Law MG; Breit SN; Lanza E; Brown , 2012, 'Serum Macrophage Inhibitory Cytokine-1 (MIC-1/GDF15): A Potential Screening Tool for the Prevention of Colon Cancer?', Cancer Epidemiology Biomarkers and Prevention, vol. 21, pp. 337 - 346, http://dx.doi.org/10.1158/1055-9965.EPI-11-0786
    Journal articles | 2011
    Professor Samuel Norbert Breit
    Tsai VWW; Mohammad MG; Tolhurst O; Breit SN; Sawchenko P; Brown DA, 2011, 'CCAAT/enhancer binding protein-CEBPD, expression by dendritic cells regulates CNS autoimmune inflammatory disease', The Journal of Neuroscience, vol. 31, pp. 17612 - 17621, http://dx.doi.org/10.1523/?JNEUROSCI.3449-11.2011
    Journal articles | 2011
    Professor Samuel Norbert Breit
    Breit SN; Johnen H; Cook AD; Tsai VWW; Mohammad MG; Tamara K; Hong PZ; Marquis C; Lele J; Lockwood G; Lee-Ng M; Husaini Y; Wu L; Hamilton JA; Brown DA, 2011, 'The TGF-β superfamily cytokine, MIC-1/GDF15: A pleotrophic cytokine with roles in inflammation, cancer and metabolism', Growth Factors, vol. 29, pp. 187 - 195, http://dx.doi.org/10.3109/08977194.2011.607137
    Journal articles | 2011
    Professor Samuel Norbert Breit
    Mynott A; Harrop SJ; Brown LJ; Breit SN; Kobe B; Curmi PM, 2011, 'Crystal structure of importin-$B&AB bound to a peptide bearing the nuclear localisation signal from chloride intracellular channel protein 4', FEBS Journal, vol. 278, pp. 1662 - 1675, http://dx.doi.org/10.1111/j.1742-4658.2011.08086.x
    Journal articles | 2011
    Professor Samuel Norbert Breit
    Goodchild SC; Angstmann CN; Breit SN; Curmi PM; Brown LJ, 2011, 'Transmembrane extension and oligomerization of the CLIC1 chloride intracellular channel protein upon membrane interaction', Biochemistry, vol. 50, pp. 10887 - 10897, http://dx.doi.org/10.1021/bi2012564
    Journal articles | 2011
    Professor Samuel Norbert Breit
    Mahon KL; Chatfield MD; Lee-Ng M; Breit SN; Brown DA; Molloy MP; Marx GM; Pavlakis N; Boyer MJ; Stockler MR; Wykes R; Henshall SM; Sutherland RL; Horvath L, 2011, 'Cytokines' profiles to predict chemotherapy outcome in castration-resistant prostate cancer (CRPC).', JOURNAL OF CLINICAL ONCOLOGY, vol. 29, http://dx.doi.org/10.1200/jco.2011.29.15_suppl.4598
    Journal articles | 2011
    Professor Samuel Norbert Breit
    Brown DA; Tsai VWW; Mohammad MG; Tolhurst O; Breit SN; Sawchenko PE, 2011, 'CCAAT/enhancer binding protein-delta (C/EBPdelta) regulates Th17/Treg balance via an antigen presenting cell - interleukin-10 dependent mechanism in neuroinflammation', MULTIPLE SCLEROSIS JOURNAL, vol. 17, pp. S344 - S344, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209137301142&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 2010
    Professor Samuel Norbert Breit
    Roth P; Junker M; Tritschler I; Mittelbronn M; Dombrowski Y; Breit SN; Tabatabai G; Wick W; Weller M; Wischhusen J, 2010, 'GDF-15 contributes to proliferation and immune escape of malignant gliomas', Clinical Cancer Research, vol. 16, pp. 3559 - 3851, http://dx.doi.org/10.1158/1078-0432.CCR-10-0705
    Journal articles | 2010
    Professor Samuel Norbert Breit
    Skipworth R; Deans DAC; Tan BHL; Sangster K; Paterson-Brown S; Brown DA; Hunter M; Breit SN; Ross JA; Fearson KCH; Hunter M, 2010, 'Plasma MIC-1 corelates with systemic inflammation but is not an independent determinant of nutritional status or survival in oesophago-gastric cancer', British Journal of Cancer, vol. 102, pp. 665 - 672, http://dx.doi.org/10.1038/sj.bjc.6605532
    Journal articles | 2010
    Professor Samuel Norbert Breit
    Bauskin AR; Jiang L; Luo X; Brown DA; Breit SN, 2010, 'The TGF-b superfamily cytokine MIC-1/GDF15: secretory mechanisms facilitate creation of latent stromal stores', Journal of Interferon and Cytokine Research, vol. 30, pp. 389 - 397, http://dx.doi.org/10.1089/jir.2009.0052
    Journal articles | 2010
    Professor Samuel Norbert Breit
    Wiklund F; Bennet AM; Magnusson PKE; Eriksson UK; Lindmark F; Wu L; Yaghoutyfam N; Marquis C; Stattin P; Pedersen NL; Adami H; Gronberg H; Breit SN; Brown DA, 2010, 'Macrophage inhibitory cytokine-1 (MIC-1/GDF15): a new marker of all-cause mortality', Aging Cell, vol. 9, pp. 1057 - 1064, http://dx.doi.org/10.1111/j.1474-9726.2010.00629.x
    Journal articles | 2010
    Professor Samuel Norbert Breit
    Qiu MR; Jiang L; Matthaei KI; Schoenwaelder S; Kuffner T; Mangin P; Joseph JE; Low J; Connor DE; Valenzuela SM; Curmi P; Brown LJ; Mahaut-Smith MP; Jackson S; Breit SN, 2010, 'Generation and characterization of mice with null mutation of the chloride intracellular channel 1 gene', Genesis, vol. 48, pp. 127 - 136, http://dx.doi.org/10.1002/dvg.20590
    Journal articles | 2010
    Professor Samuel Norbert Breit
    Littler DR; Harrop SJ; Goodchild SC; Phang J; Mynott AV; Jiang L; Valenzuela SM; Mazzanti M; Brown LJ; Breit SN; Curmi PM, 2010, 'The enigma of the CLIC proteins: Ion channels,redox proteins,enzymes,scaffolding proteins?', FEBS Letters, vol. 584, pp. 2093 - 2101, http://dx.doi.org/10.1016/j.febslet.2010.01.027
    Journal articles | 2010
    Professor Samuel Norbert Breit
    Goodchild SC; Howell MW; Littler DR; Mandyam RA; Sale KL; Mazzanti M; Breit SN; Curmi PMG; Brown LJ, 2010, 'Metamorphic response of the CLIC1 chloride intracellular ion channel protein upon membrane interaction', Biochemistry, vol. 49, pp. 5278 - 5289, http://dx.doi.org/10.1021/bi100111c
    Journal articles | 2010
    Professor Samuel Norbert Breit
    Qiu MR; Jiang L; Matthaei KI; Schoenwaelder SM; Kuffner T; Mangin P; Joseph JE; Low J; Connor D; Valenzuela SM; Curmi PMG; Brown LJ; Mahaut-Smith M; Jackson SP; Breit SN, 2010, 'Erratum: Generation and characterization of mice with null mutation of the chloride intracellular channel 1 gene', Genesis, vol. 48, pp. 351 - 351, http://dx.doi.org/10.1002/dvg.20616
    Journal articles | 2009
    Professor Samuel Norbert Breit
    Shnaper S; Desbaillets I; Brown DA; Murat A; Migliavacca E; Schluep M; Ostermann S; Hamou MF; Stupp R; Breit SN; De Tribolet N; Hegi ME, 2009, 'Elevated levels of MIC-1/GDF15 in the cerebrospinal fluid of patients are associated with glioblastoma and worse outcome', International Journal of Cancer, vol. 125, pp. 2624 - 2630, http://dx.doi.org/10.1002/ijc.24639
    Journal articles | 2009
    Professor Samuel Norbert Breit
    Brown DA; Lindmark F; Stattin P; Bälter K; Adami HO; Zheng SL; Xu J; Isaacs WB; Grönberg H; Breit SN; Wiklund FE, 2009, 'Macrophage inhibitory cytokine 1: A new prognostic marker in prostate cancer', Clinical Cancer Research, vol. 15, pp. 6658 - 6664, http://dx.doi.org/10.1158/1078-0432.CCR-08-3126
    Journal articles | 2009
    Professor Samuel Norbert Breit
    Zhao L; Lee BY; Brown DA; Molloy M; Marx GM; Pavlakis N; Boyer MJ; Stockler M; Kaplan W; Breit SN; Sutherland RL; Henshall SM; Horvath LG, 2009, 'Identification of candidate biomarkers of therapeutic response to docetaxel by proteomic profiling', Cancer research, vol. 69, pp. 7696 - 7703, http://dx.doi.org/10.1158/0008-5472.CAN-08-4901
    Journal articles | 2009
    Professor Samuel Norbert Breit
    Boyle G; Pedley J; Martyn A; Banducci K; Strutton G; Brown DA; Breit SN; Parsons PG, 2009, 'Macrophage inhibitory cytokine-1 is overexpressed in malignant melanoma and is associated with tumorigenicity', Journal of Investigative Dermatology, vol. 129, pp. 383 - 391, http://dx.doi.org/10.1038/jid.2008.270
    Journal articles | 2009
    Professor Samuel Norbert Breit
    Wakchoure S; Swain T; Hentunen T; Bauskin AR; Brown DA; Breit SN; Vuopala K; Harris K; Selander K, 2009, 'Expression of macrophage inhibitory cytokine-1 in prostate cancer bone metastases induces osteoclast activation and weight loss', Prostate, vol. 69, pp. 652 - 661, http://dx.doi.org/10.1002/pros.20913
    Journal articles | 2009
    Professor Samuel Norbert Breit
    Goodchild SC; Howell M; Cordina NM; Littler DR; Breit SN; Curmi PM; Brown LJ, 2009, 'Oxidation promotes insertion of the CLIC1 chloride intracellular channel into the membrane', European Biophysics Journal With Biophysics Letters, vol. 39, pp. 129 - 138, http://dx.doi.org/10.1007/s00249-009-0450-0
    Journal articles | 2009
    Professor Samuel Norbert Breit
    Zaunders J; Munier ML; Seddiki N; Pett SL; Ip S; Bailey M; Xu Y; Brown KJ; Dyer W; Kim MS; De Rose R; Kent SJ; Jiang L; Breit SN; Emery S; Cunningham AL; Cooper DA; Kelleher AD, 2009, 'High levels of human antigen-specific CD4+ T cells in peripheral blood revealed by stimulated coexpression of CD25 and CD134 (OX40)', Journal of Immunology, vol. 183, pp. 2827 - 2836, http://dx.doi.org/10.4049/jimmunol.0803548
    Journal articles | 2009
    Professor Samuel Norbert Breit
    Littler D; Brown LJ; Breit SN; Perrakis A; Curmi PM, 2009, 'Structure of human CLIC3 at 2 A resolution', Proteins - Structure Function and Bioinformatics, vol. 78, pp. 1594 - 1600, http://dx.doi.org/10.1002/prot.22675
    Journal articles | 2009
    Professor Samuel Norbert Breit
    Horvath L; Zhao L; Lee B; Brown D; Molloy M; Marx G; Boyer M; Breit S; Sutherland R; Henshall S, 2009, 'Identification of candidate biomarkers of therapeutic response to docetaxel in hormone-refractory prostate cancer by proteomic profiling.', J Clin Oncol, vol. 27, pp. 11010, http://www.ncbi.nlm.nih.gov/pubmed/27963974
    Journal articles | 2008
    Professor Samuel Norbert Breit
    Milton RH; Abeti R; Averaimo S; De Biasi S; Vitellaro L; Jiang L; Curmi PM; Breit SN; Duchen MR; Mazzanti M, 2008, 'CLIC1 function is required for B-amyloid-induced generation of reactive oxygen species by microglia', Journal of Neuroscience, vol. 28, pp. 11488 - 11499, http://dx.doi.org/10.1523/JNEUROSCI.2431-08.2008
    Journal articles | 2008
    Professor Samuel Norbert Breit
    Littler DR; Luciani P; Pankhurst G; Mandyam R; Mazzanti M; Tanda S; Berryman M; Breit SN; Curmi PM; Brown LJ; Mynott AV; Harrop SJ, 2008, 'Comparison of vertebrate and invertebrate CLIC proteins: The crystal structures of Caenorhabditis elegans EXC-4 and Drosophila melanogaster DmCLIC', Proteins - Structure Function and Bioinformatics, vol. 71, pp. 364 - 378, http://dx.doi.org/10.1002/prot.21704
    Journal articles | 2008
    Professor Samuel Norbert Breit
    Paradisi S; Matteucci A; Fabrizi C; Denti M; Abeti R; Breit SN; Malchiodi-Albedi F; Mazzanti M, 2008, 'Blockade of chloride intracellular ion channel 1 stimulates a beta phagocytosis', Journal of Neuroscience Research, vol. 86, pp. 2488 - 2498, http://dx.doi.org/10.1002/jnr.21693
    Journal articles | 2007
    Professor Samuel Norbert Breit
    Selander KS; Brown DA; Sequeiros GB; Hunter M; Desmond R; Parpala T; Risteli J; Breit SN; Jukkola-Vuorinen A, 2007, 'Serum macrophage inhibitory cytokine-1 concentrations correlate with the presence of prostate cancer bone metastases', Cancer Epidemiology Biomarkers and Prevention, vol. 16, pp. 532 - 537, http://dx.doi.org/10.1158/1055-9965.EPI-06-0841
    Journal articles | 2007
    Professor Samuel Norbert Breit
    Johnen H; Lin S; Kuffner T; Brown DA; Tsai V; Bauskin AR; Wu L; Pankhurst G; Jiang L; Junankar S; Hunter M; Fairlie WD; Lee NJ; Enriquez R; Baldock P; Corey E; Apple F; Murakami M; Lin E; Wang CC; During M; Sainsbury A; Herzog H; Breit SN, 2007, 'Tumor-induced anorexia and weight loss are mediated by the TGF-beta superfamily cytokine MIC-1', Nature Medicine, vol. 13, pp. 1333 - 1340, http://dx.doi.org/10.1038/nm1677
    Journal articles | 2007
    Professor Samuel Norbert Breit
    Brown DA; Moore JJ; Johnen H; Smeets TJ; Bauskin AR; Kuffner T; Weedon H; Milliken ST; Tak PP; Smith MD; Breit SN, 2007, 'Serum macrophage inhibitory cytokine 1 in rheumatoid arthritis - A potential marker of erosive joint destruction', Arthritis Care & Research, vol. 56, pp. 753 - 764, http://dx.doi.org/10.1002/art.22410
    Journal articles | 2007
    Professor Samuel Norbert Breit
    Cromer B; Gorman M; Hansen G; Adams J; Coggan M; Littler DR; Brown LJ; Mazzanti M; Breit SN; Curmi PM; Dulhunty A; Board P; Parker M, 2007, 'Structure of the Janus protein human CLIC2', Journal of Molecular Biology, vol. 374, pp. 719 - 731, http://dx.doi.org/10.1016/j.jmb.2007.09.041
    Journal articles | 2006
    Professor Samuel Norbert Breit
    Agarwal MK; Hastak K; Jackson MW; Breit SN; Stark GR; Agarwal ML, 2006, 'Macrophage inhibitory cytokine 1 mediates a p53-dependent protective arrest in S phase in response to starvation for DNA precursors', Proceedings of the National Academy of Sciences of the United States of America, vol. 103, pp. 16278 - 16283, http://dx.doi.org/10.1073/pnas.0607210103
    Journal articles | 2006
    Professor Samuel Norbert Breit
    Bauskin AR; Brown DA; Kuffner T; Johnen H; Luo X; Hunter M; Breit SN, 2006, 'Role of macrophage inhibitory cytokine-1 in tumorigenesis and diagnosis of cancer', Cancer research, vol. 66, pp. 4983 - 4986, http://dx.doi.org/10.1158/0008-5472.CAN-05-4067
    Journal articles | 2006
    Professor Samuel Norbert Breit
    Xu J; Kimball T; Lorenz J; Brown DA; Bauskin AR; Klevitsky R; Hewett T; Breit SN; Molkentin J, 2006, 'GDF15/MIC-1 functions as a protective and antihypertrophic factor released from the myocardium in association with SMAD protein activation', Circulation Research, vol. 98, pp. 342 - 350, http://dx.doi.org/10.1161/01.RES.0000202804.84885.d0
    Journal articles | 2006
    Professor Samuel Norbert Breit
    Koopmann J; Rosenzweig C; Zhang ZP; Canto M; Brown DA; Hunter M; Yeo CB; Chan DJ; Breit SN; Goggins M; Hunter M, 2006, 'Serum markers in patients with resectable pancreatic adenocarcinoma: Macrophage inhibitory cytokine 1 versus CA19-9', Clinical Cancer Research, vol. 12, pp. 442 - 446, http://dx.doi.org/10.1158/1078-0432.CCR-05-0564
    Journal articles | 2006
    Professor Samuel Norbert Breit
    Rasiah KK; Kench JG; Gardiner-Garden M; Biankin AV; Golovsky D; Brenner PC; Kooner R; O Neill G; Turner J; Delprado W; Lee CS; Brown DA; Breit SN; Grygiel JJ; Horvath LG; Stricker PD; Sutherland RL; Henshall SM, 2006, 'Aberrant neuropepticle Y and macrophage inhibitory cytokine-1 expression are early events in prostate cancer development and are associated with poor prognosis', Cancer epidemiology biomarkers and prevention, vol. 15, pp. 711 - 716, http://dx.doi.org/10.1158/1055-9965.EPI-05-0752
    Journal articles | 2006
    Professor Samuel Norbert Breit
    Brown DA; Stephan C; Ward RL; Law MG; Hunter M; Bauskin AR; Amin J; Jung K; Diamandis E; Hampton GM; Russell PJ; Giles GG; Breit SN, 2006, 'Measurement of serum levels of macrophage inhibitory cytokine 1 combined with prostate-specific antigen improves prostate cancer diagnosis', Clinical Cancer Research, vol. 12, pp. 89 - 96, http://dx.doi.org/10.1158/1078-0432.CCR-05-1331
    Journal articles | 2006
    Professor Samuel Norbert Breit
    Stephan C; Xu C; Brown DA; Breit SN; Michael AW; Nakamura T; Diamandis E; Meyer H; Cammann H; Jung K, 2006, 'Three new serum markers for prostate cancer detection within a percent free PSA-based artificial neural network', Prostate, vol. 66, pp. 651 - 659, http://dx.doi.org/10.1002/pros.20381
    Journal articles | 2005
    Professor Samuel Norbert Breit
    Saeki K; Yasugi E; Okuma E; Breit SN; Nakamura M; Toda T; Kaburagi Y; Yuo A, 2005, 'Proteomic analysis on insulin signaling in human hematopoietic cells: identification of CLIC1 and SRp20 as novel downstream effectors of insulin', American Journal of Physiology - Endocrinology and Metabolism, vol. 289, pp. 419 - 428, http://dx.doi.org/10.1152/ajpendo.00512.2004
    Journal articles | 2005
    Professor Samuel Norbert Breit
    Weber F; Byrne S; Le S; Brown DA; Breit SN; Scolyer R; Halliday GM, 2005, 'Transforming growth factor-beta(1) immobilises dendritic cells within skin tumours and facilitates tumour escape from the immune system', Cancer Immunology and Immunotherapy, vol. 54, pp. 898 - 906, http://dx.doi.org/10.1007/s00262-004-0652-3
    Journal articles | 2005
    Professor Samuel Norbert Breit
    Liu T, 2005, 'The propeptide mediates formation of stromal stores of ProMIC-1: role in determining prostate cancer outcome', Cancer Research, vol. 65, pp. 2330 - 2336, http://dx.doi.org/10.1158/0008-5472.CAN-04-3827
    Journal articles | 2005
    Professor Samuel Norbert Breit
    Littler DR; Assaad NN; Harrop SJ; Brown LJ; Pankhurst G; Luciani P; Aguilar M; Mazzanti M; Berryman M; Breit SN; Curmi PM, 2005, 'Crystal structure of the soluble form of the redox-regulated chloride ion channel protein CLIC4', FEBS Journal, vol. 272, pp. 4996 - 5007, http://dx.doi.org/10.1111/j.1742-4658.2005.04909.x
    Journal articles | 2004
    Professor Samuel Norbert Breit
    Tong S; Marjono B; Brown DA; Mulvey S; Breit SN; Manuelpillai U; Wallace EM, 2004, 'Serum concentrations of macrophage inhibitory cytokine 1 (MIC 1) as apredictor of miscarriage', Lancet, vol. 363, pp. 129 - 130, http://dx.doi.org/10.1016/S0140-6736(03)15265-8
    Journal articles | 2004
    Professor Samuel Norbert Breit
    Koopmann J; Buckhaults P; Brown DA; Zahurak M; Sato N; Fukushima N; Sokoll L; Chan DW; Yeo C; Hruban R; Breit SN; Kinzler KW; Vogelstein B; Goggins M, 2004, 'Serum macrophage inhibitory cytokine 1 as a marker of pancreatic andother periampullary cancers', Clinical Cancer Research, vol. 10, pp. 2386 - 2392, http://dx.doi.org/10.1158/1078-0432.CCR-03-0165
    Journal articles | 2004
    Professor Samuel Norbert Breit
    Littler DR; Fairlie WD; Brown LJ; Pankhurst G; Pankhurst SM; Demaere MZ; Campbell TJ; Bauskin AR; Tonini R; Mazzanti M; Breit SN; Curmi PM; Harrop SJ, 2004, 'The intracellular chloride ion channel protein CLIC1 undergoes a redox-controlled structural transition', The Journal of Biological Chemistry, vol. 279, pp. 9298 - 9305, http://dx.doi.org/10.1074/jbc.M308444200
    Journal articles | 2004
    Professor Samuel Norbert Breit
    Wallace EM; Marjono B; Brown DA; Crossley J; Aitken DK; Tong S; Breit SN, 2004, 'Maternal serum and amniotic fluid levels of macrophage inhibitorycytokine 1 in Down syndrome and chromosomally normal pregnancies', Prenatal Diagnosis, vol. 24, pp. 224 - 226, http://dx.doi.org/10.1002/pd.791
    Journal articles | 2004
    Professor Samuel Norbert Breit
    Marjono B; Manuelpillai U; Dimitriadis E; Salamonsen L; Breit S; Wallace E, 2004, '270.Macrophage inhibitory cytokine-1 at the maternal - fetal interface in early pregnancy', Reproduction, Fertility and Development, vol. 16, pp. 270 - 270, http://dx.doi.org/10.1071/srb04abs270
    Journal articles | 2003
    Professor Samuel Norbert Breit
    Keelan JA; Wang K; Chaiworapongsa T; Romero R; Mitchell MD; Sato TA; Brown DA; Fairlie WD; Breit SN, 2003, 'Macrophase hihibitory cytokine 1 (MIC-1) in fetal membranes and amniotic fluid from pregnancies with and without preterm labour and premature rupture of membranes', Molecular Human Reproduction, vol. 9, pp. 535 - 540, http://dx.doi.org/10.1093/molehr/gag068
    Journal articles | 2003
    Professor Samuel Norbert Breit
    Yang H; Filipovic Z; Brown DA; Breit SN; Vassilev LT, 2003, 'Macrophage inhibitory cytokine-1: a novel biomarker for p53 pathway activation', Molecular Cancer Therapeutics, vol. 2, pp. 1023 - 1029
    Journal articles | 2003
    Professor Samuel Norbert Breit
    Marjono AB; Brown DA; Horton KE; Wallace EM; Breit SN; Manuelpillai U, 2003, 'Macrophage Inhibitory Cytokine-1 in Gestational Tissues and Maternal Serum in Normal and Pre-eclamptic Pregnancy', Placenta, vol. 24, pp. 100 - 106, http://dx.doi.org/10.1053/plac.2002.0881
    Journal articles | 2003
    Professor Samuel Norbert Breit
    Liu T, 2003, 'Large-scale delineation of secreted protein biomarkers overexpressed in cancer tissue and serum', Proceedings of the National Academy of Sciences of the United States of America, vol. 100, pp. 3410 - 3415, http://dx.doi.org/10.1073/pnas.0530278100
    Journal articles | 2003
    Professor Samuel Norbert Breit
    Brown DA; Ward RL; Buckhaults P; Liu T; Romans KE; Hawkins NJ; Bauskin AR; Kinzler KW; Vogelstein B; Breit SN, 2003, 'MIC 1 serum level and genotype: Associations with progress and prognosis of colorectal carcinoma', Clinical Cancer Research, vol. 9, pp. 2642 - 2650
    Journal articles | 2003
    Professor Samuel Norbert Breit
    Singarayar SB; Bursill JA; Wyse KR; Bauskin AR; Wu WM; Vandenberg JI; Breit SN; Campbell TJ, 2003, 'Extracellular acidosis modulates drug block of Kv4.3 currents by flecainide and quinidine', Journal of Cardiovascular Electrophysiology, vol. 14, pp. 641 - 650, http://dx.doi.org/10.1046/j.1540-8167.2003.03026.x
    Journal articles | 2003
    Professor Samuel Norbert Breit
    Liu T; Bauskin AR; Zaunders J; Brown DA; Pankhurst S; Russell PJ; Breit SN, 2003, 'Macrophage inhibitory cytokine 1 reduces cell adhesion and induces apoptosis in prostate cancer cells', Cancer research, vol. 63, pp. 5034 - 5040
    Journal articles | 2003
    Professor Samuel Norbert Breit
    Torres M; Bansal PS; Sunde M; Clarke CE; Bursill JA; Smith DG; Bauskin AR; Breit SN; Campbell TJ; Alewood P; Kuchel PW; Vandenberg JI, 2003, 'Structure of the HERGK+ channel S5P extracellulal linker: Role of an amphipathic a-helix in C-type inactivation.', Journal of Biochemistry, vol. 278, pp. 42136 - 42148, http://dx.doi.org/10.1074/jbc.M212824200
    Journal articles | 2002
    Professor Samuel Norbert Breit
    Albertoni M; Shaw PH; Nozaki M; Sophie G; Tenan M; Hamou MF; Fairlie DW; Breit SN; Paralkar VM; De Tribolet N; Van Meir EG; Hegi ME, 2002, 'Anoxia induces macrophage inhibitory cytokine-1 (MIC-1) in glioblastoma cells independently of p53 and HIF-1', Oncogene, vol. 21, pp. 4212 - 4219, http://dx.doi.org/10.1038/sj.onc.1205610
    Journal articles | 2002
    Professor Samuel Norbert Breit
    Liu T, 2002, 'Concentration in plasma of macrophage inhibitory cytokine-1 and risk of cardiovascular events in women: a nested case-control study', Lancet, vol. 359, pp. 2159 - 2163, http://dx.doi.org/10.1016/S0140-6736(02)09093-1
    Journal articles | 2002
    Professor Samuel Norbert Breit
    Warton K; Tonini R; Fairlie WD; Matthews JM; Valenzuela SM; Qiu MR; Wu WM; Pankhurst S; Bauskin AR; Harrop SJ; Campbell TJ; Curmi PM; Breit SN; Mazzanti M, 2002, 'Recombinant CLIC1 (NCC27) assembles in lipid bilayers via a pH-dependent two-state process to form chloride ion channels with identical characteristics to those observed in Chinese Hamster Ovary cells expressing CLIC1', The Journal of Biological Chemistry, vol. 277, pp. 26003 - 26011, http://dx.doi.org/10.1074/jbc.M203666200
    Journal articles | 2002
    Professor Samuel Norbert Breit
    Min D; Moore AG; Breit SN; Bain MA; Lyons JG, 2002, 'Activation of Macrophage Promatrix metalloproteinase-9 by Lipopolysaccharide-Associated Proteinases', Journal of Immunology, vol. 168, pp. 2449 - 2455, http://dx.doi.org/10.4049/jimmunol.168.5.2449
    Journal articles | 2002
    Professor Samuel Norbert Breit
    Qiu MR; Campbell TJ; Breit SN, 2002, 'A potassium ion channel is involved in cytokine production by activated human macrophages', Clinical and Experimental Immunology, vol. 130, pp. 67 - 74, http://dx.doi.org/10.1046/j.1365-2249.2002.01965.x
    Journal articles | 2002
    Professor Samuel Norbert Breit
    Singarayar SB; Singleton CB; Tie H; Wyse KR; Bursill JA; Bauskin AR; Wu WM; Valenzuela SM; Breit SN; Campbell TJ, 2002, 'Effects of components of ischemia on the Kv4.3 current stably expressed in chinese hamster ovary cells', Journal of Mol Cell Caridiol, vol. 34, pp. 197 - 207, http://dx.doi.org/10.1006/jmcc.2001.1502
    Journal articles | 2002
    Professor Samuel Norbert Breit
    Liu T, 2002, 'Antibody-based approach to high-volume genotyping for MIC-1 polymorphism', BioTechniques, vol. 33, pp. 118 - 120
    Journal articles | 2002
    Professor Samuel Norbert Breit
    Parson D; Schlieder B; Beatty P, 2002, 'Extension language automation of embedded system debugging', Automated Software Engineering, vol. 9, pp. 7 - 39, http://dx.doi.org/10.1023/A:1013276002164
    Journal articles | 2002
    Professor Samuel Norbert Breit
    Qiu MR; Campbell TJ; Breit SN, 2002, 'Erratum: A potassium ion channel is involved in cytokine production by activated human macrophages (Clinical and Experimental Immunology (2002) 130 (67-74))', Clinical and Experimental Immunology, vol. 130, pp. 559 - 561, http://dx.doi.org/10.1046/j.1365-2249.2002.02041.x
    Journal articles | 2001
    Professor Samuel Norbert Breit
    Christofi FL; Zhang H; Yu JG; Guzman J; Xue J; Kim M; Wang YZ; Cooke HJ, 2001, 'Differential gene expression of adenosine A1, A2a, A2b, and A3 receptors in the human enteric nervous system', Journal of Comparative Neurology, vol. 439, pp. 46 - 64, http://dx.doi.org/10.1002/cne.1334
    Journal articles | 2001
    Professor Samuel Norbert Breit
    Schober A; Bottner M; Strelau J; Kinscherf R; Bonaterra GA; Barth M; Schilling L; Fairlie WD; Breit SN; Unisicker K, 2001, 'Expression of growth differentiation factor-15/ macrophage inhibitory cytokine-1 (CDF-15/MIC-1) in the perinatal adult and injured rat brain', Journal of Comparative Neurology, vol. 439, pp. 32 - 45, http://dx.doi.org/10.1002/cne.1333
    Journal articles | 2001
    Professor Samuel Norbert Breit
    Harrop SJ; Demaere MZ; Fairlie WD; Reztsova T; Valenzuela SM; Mazzanti M; Tonini R; Qiu MR; Jankova L; Warton K; Bauskin AR; Wu WM; Pankhurst S; Campbell TJ; Breit SN; Curmi PM, 2001, 'Crystal structure of a soluble form of the Intracellular Chloride Ion Channel CLIC1 (NCC27) at 1.4-A resolution', The Journal of Biological Chemistry, vol. 276, pp. 44993 - 45000, http://dx.doi.org/10.1074/jbc.M107804200
    Journal articles | 2001
    Professor Samuel Norbert Breit
    Fairlie WD; Zhang H; Wu WM; Pankhurst S; Bauskin AR; Russell PK; Brown PK; Breit SN, 2001, 'The propeptide of the transforming growth factor beta superfamily member macrophage inhibitory cytokine-1 (MIC-1) Is a multifunctional domain that can facilitate protein folding and secretion', The Journal of Biological Chemistry, vol. 276, pp. 16911 - 16918, http://dx.doi.org/10.1074/jbc.M010000200
    Journal articles | 2001
    Professor Samuel Norbert Breit
    Fairlie WD; Russell PK; Wu WM; Moore AG; Zhang H; Brown PK; Bauskin AR; Breit SN, 2001, 'Epitope mapping of the transforming growth factor-beta superfamily protein macrophage inhibitory cytokine-1 (MIC-1): indentification of at least five distinct epitope specificities', Biochemistry, vol. 40, pp. 65 - 73, http://dx.doi.org/10.1021/bi001064p
    Journal articles | 2001
    Professor Samuel Norbert Breit
    Tie H; Walker BD; Singleton CB; Bursill JA; Wyse KR; Campbell TJ; Valenzuela SM; Breit SN, 2001, 'Clozapine and sudden death [10]', Journal of Clinical Psychopharmacology, vol. 21, pp. 630 - 632, http://dx.doi.org/10.1097/00004714-200112000-00023
    Journal articles | 2000
    Professor Samuel Norbert Breit
    Fairlie WD; Zhang HP; Brown PK; Russell PK; Bauskin AR; Breit SN, 2000, 'Expression of a TGF-β superfamily protein, macrophage inhibitory cytokine-1, in the yeast Pichia pastoris', Gene, vol. 254, pp. 67 - 76, http://dx.doi.org/10.1016/S0378-1119(00)00295-X
    Journal articles | 2000
    Professor Samuel Norbert Breit
    Valenzuela SM; Mazzanti M; Tonini R; Qiu MR; Warton K; Musgrove EA; Campbell TJ; Breit SN, 2000, 'The nuclear chloride ion channel NCC27 is involved in regulation of the cell cycle', Journal of Physiology, vol. 529, pp. 541 - 552, http://dx.doi.org/10.1111/j.1469-7793.2000.00541.x
    Journal articles | 2000
    Professor Samuel Norbert Breit
    Tie H; Walker BD; Singleton CB; Valenzuela SM; Bursill JA; Wyse KR; Breit SN; Campbell TJ, 2000, 'Inhibiton of HERG potassium channels by the antimalarial agent halofantrine', British Journal of Pharmacology, vol. 130, pp. 1967 - 1975, http://dx.doi.org/10.1038/sj.bjp.0703470
    Journal articles | 2000
    Professor Samuel Norbert Breit
    Moore AG; Brown DA; Fairlie WD; Bauskin AR; Brown PK; Munier MLC; Russell PK; Salamonsen LA; Wallace EM; Breit SN, 2000, 'The transforming growth factor-β superfamily cytokine macrophage inhibitory cytokine-1 is present in high concentrations in the serum of pregnant women', Journal of Clinical Endocrinology and Metabolism, vol. 85, pp. 4781 - 4788, http://dx.doi.org/10.1210/jc.85.12.4781
    Journal articles | 2000
    Professor Samuel Norbert Breit
    Tonini R; Ferroni A; Valenzuela SM; Warton K; Campbell TJ; Breit SN; Mazzanti M, 2000, 'Functional characterization of the NCC27 nuclear protein in stable transfected CHO-K1 cells', Federation of American Societies for Experimantal Biology Journal, vol. 14, pp. 1171 - 1178
    Journal articles | 2000
    Professor Samuel Norbert Breit
    Gilmour TK; Wilkinson B; Breit SN; Kossard S, 2000, 'Analysis of dendritic cell populations using a revised histological staging of morphoea', British Journal of Dermatology, vol. 143, pp. 1183 - 1192, http://dx.doi.org/10.1046/j.1365-2133.2000.03886.x
    Journal articles | 2000
    Professor Samuel Norbert Breit
    Bauskin AR; Zhang H; Fairlie WD; He XY; Russell PJ; Moore A; Brown DM; Stanley K; Breit SN, 2000, 'The Propeptide of macrophage inhibitory cytokine (MIC-1) , a TGF-b superfamily member, act as a quality control determinant for correctly folded MIC-1.', European Molecular Biology Organization, vol. 19, pp. 2212 - 2220, http://dx.doi.org/10.1093/emboj/19.10.2212
    Journal articles | 2000
    Professor Samuel Norbert Breit
    Tie H; Walker BD; Valenzuela SM; Breit SN; Campbell TJ, 2000, 'The heart of psychotropic drug therapy.', Lancet, vol. 355, pp. 1825, http://dx.doi.org/10.1016/S0140-6736(05)73083-X
    Journal articles | 2000
    Professor Samuel Norbert Breit
    Walker BD; Singleton CB; Tie H; Bursill JA; Wyse KR; Valenzuela SM; Breit SN; Campbell LV, 2000, 'Comparative effects of azimilide and ambasilide on the human ether-a-go-go-related gene (HERG) potassium channel', Cardiovascular Research, vol. 48, pp. 44 - 58, http://dx.doi.org/10.1016/S0008-6363(00)00155-3
    Journal articles | 2000
    Professor Samuel Norbert Breit
    Warton K; Valenzuela S; Tonini R; Mazzanti M; Breit S, 2000, 'Intracellular Ion Channel NCC27 Moves between a Soluble and a Transmembrane State', Biochemical Society Transactions, vol. 28, pp. A471 - A471, http://dx.doi.org/10.1042/bst028a471c
    Journal articles | 2000
    Professor Samuel Norbert Breit
    Singleton CB; Walker BD; Tie H; Bursill JA; Wyse KR; Valenzuela SM; Breit SN; Campbell TJ, 2000, 'Potent blockade by quinidine of the Kv4.3 current: Significance with regard to treatment of the brugada syndrome', Heart, Lung and Circulation, vol. 9, pp. A92 - A92, http://dx.doi.org/10.1046/j.1443-9506.2000.06115.x
    Journal articles | 2000
    Professor Samuel Norbert Breit
    Tie H; Walker BD; Singleton CB; Bursill J; Wyse K; Valenzuela S; Breit SN; Campbell TJ, 2000, 'The antipsychotic agents thioridazine, chlorpromazine and clozapine block the human-ether-a-go-go-related gene (HERG) potassium channel: Cellular mechanism for proarrhythmia', Heart, Lung and Circulation, vol. 9, pp. A109 - A109, http://dx.doi.org/10.1046/j.1443-9506.2000.06796.x
    Journal articles | 2000
    Professor Samuel Norbert Breit
    Walker BD; Tie H; Singleton CB; Bursill JA; Wyse KR; Valenzuela SM; Breit SN; Campbell TJ, 2000, 'Hyperkalaemia and acidosis modify HERG channel biophysical properties and antagonise inhibition by sotalol', Heart, Lung and Circulation, vol. 9, pp. A131 - A131, http://dx.doi.org/10.1046/j.1443-9506.2000.07650.x
    Journal articles | 1999
    Professor Samuel Norbert Breit
    Fairlie WD; Moore A; Bauskin AR; Russell PJ; Zhang H; Breit SN, 1999, 'MIC-1 is a novel TGF-beta superfamily cytokine associated with macrophage activation', Journal of Leukocyte Biology, vol. 65, pp. 2 - 5, http://dx.doi.org/10.1002/jlb.65.1.2
    Journal articles | 1999
    Professor Samuel Norbert Breit
    Walker BD; Valenzuela SM; Singleton CB; Tie H; Bursill JA; Wyse KR; Qui MR; Breit SN; Campbell TJ, 1999, 'Inhibition of HERG channels stably expressed in a mammalian cell line by the antianginal agent perhexiline maleate.', British Journal of Pharmacology, vol. 127, pp. 243 - 251, http://dx.doi.org/10.1038/sj.bjp.0702502
    Journal articles | 1999
    Professor Samuel Norbert Breit
    Walker BD; Singleton CB; Bursill JA; Wyse KR; Valenzuela SM; Qui MR; Breit SN; Campbell TJ, 1999, 'Inhibition of the human ether-a-go-go-related gene (HERG) potassium channel by cisapride: affinity for open and inactivated states', British Journal of Pharmacology, vol. 128, pp. 444 - 450, http://dx.doi.org/10.1038/sj.bjp.0702774
    Journal articles | 1999
    Professor Samuel Norbert Breit
    Singleton CB; Valenzuela SM; Walker BD; Tie H; Wyse KR; Bursill JA; Qui MR; Breit SN; Campbell TJ, 1999, 'Blockade by N-3 polyunsaturated fatty acid of the Kv4.3 current stably expressed in Chinese Hamster ovary cells', British Journal of Pharmacology, vol. 127, pp. 941 - 948, http://dx.doi.org/10.1038/sj.bjp.0702638
    Journal articles | 1999
    Professor Samuel Norbert Breit
    Breit S; Kolb HA; Häussinger D; Lang F, 1999, 'Effects of tetrabutylhydroperoxide on hepatocyte ion channels', Cellular Physiology and Biochemistry, vol. 9, pp. 133 - 138, http://dx.doi.org/10.1159/000016310
    Journal articles | 1999
    Professor Samuel Norbert Breit
    Fairlie DP; Russell PJ; Zhang H; Breit SN, 1999, 'Screening procedure for Pichia pastoris clones containing multiple copy gene inserts', BioTechniques, vol. 26, pp. 1042 - 1044
    Journal articles | 1998
    Professor Samuel Norbert Breit
    Breit S; Kolb HA; Apfel H; Haberland C; Schmitt M; Häussinger D; Graf J; Lang F, 1998, 'Regulation of ion channels in rat hepatocytes', Pflugers Archiv European Journal of Physiology, vol. 435, pp. 203 - 210, http://dx.doi.org/10.1007/s004240050502
    Journal articles | 1998
    Professor Samuel Norbert Breit
    Martin D; Bursill J; Qui MR; Breit SN; Campbell T, 1998, 'Alternative hypothesis for efficacy of macrolides in acute coronary syndromes', Lancet, vol. 351, pp. 1858 - 1859, http://dx.doi.org/10.1016/S0140-6736(05)78804-8
    Journal articles | 1997
    Professor Samuel Norbert Breit
    Bootcov MR; Bauskin AR; Valenzuela SM; Moore A; Bansal M; He C; Zhang H; Donnellan M; Mahler SM; Pryor K; Walsh BR; Nicholson RI; Fairlie DP; Por SB; Robbins JM; Breit SN, 1997, 'MIC-1, a novel macrophage inhiBitory cytokine, is a divergent memBer of the TGF-Beta superfamily cluster.', Proceedings of the National Academy of Sciences of the United States of America, vol. 94, pp. 11514 - 11519, http://dx.doi.org/10.1073/pnas.94.21.11514
    Journal articles | 1997
    Professor Samuel Norbert Breit
    Valenzuela SM; Martin DJ; Warton K; Por SB; Robbins JM; Bootcov MR; Schofield PR; Campbell TJ; Breit SN, 1997, 'Molecular cloning and expression of a chloride ion channel of cell nuclei.', The Journal of Biological Chemistry, vol. 272, pp. 12575 - 12582, http://dx.doi.org/10.1074/jbc.272.19.12575
    Journal articles | 1997
    Professor Samuel Norbert Breit
    Brown DA; Breit SN, 1997, 'Scleroderma Lung Disease', Biodrugs, vol. 8, pp. 185 - 192, http://dx.doi.org/10.2165/00063030-199708030-00004
    Journal articles | 1996
    Professor Samuel Norbert Breit
    Thornton SC; Walsh BR; Bennett S; Robbins JM; Foulcher E; Morgan GJ; Penny R; Breit SN, 1996, 'Both in vitro and in vivo irradiation are associated with induction of macrophage derived fibroblast growth factors', Clinical and Experimental Immunology, vol. 103, pp. 67 - 73, http://dx.doi.org/10.1046/j.1365-2249.1996.898598.x
    Journal articles | 1995
    Professor Samuel Norbert Breit
    Morgan GJ; Breit SN, 1995, 'Radiation and the lung: a re-evaluation of the mechanisms mediating pulmonary injury', International Journal of Radiation Oncology and Biology Physics, vol. 31, pp. 361 - 369, http://dx.doi.org/10.1016/0360-3016(94)00477-3
    Journal articles | 1995
    Professor Samuel Norbert Breit
    Walsh BR; Gooley AA; Williams KM; Breit SN, 1995, 'Identification of macrophage activation associated proteins by two-dimensional gel electrophoresis and microsequencing', Journal of Leukocyte Biology, vol. 57, pp. 507 - 512, http://dx.doi.org/10.1002/jlb.57.3.507
    Journal articles | 1995
    Professor Samuel Norbert Breit
    Martin DJ; Bootcov MR; Campbell TJ; French PW; Breit SN, 1995, 'Human macrophages contain a stretch-sensitive potassium channel that is activated by adherence and cytokines', Journal of Membrane Biology, vol. 147, pp. 305 - 315, http://dx.doi.org/10.1007/BF00234528
    Journal articles | 1995
    Professor Samuel Norbert Breit
    Waldegger S; Beisse F; Apfel H; Breit S; Kolb HA; Häussinger D; Lang F, 1995, 'Electrophysiological effects of progesterone on hepatocytes', Biochimica et Biophysica Acta - Molecular Cell Research, vol. 1266, pp. 186 - 190, http://dx.doi.org/10.1016/0167-4889(94)00236-8
    Journal articles | 1995
    Professor Samuel Norbert Breit
    Breit SN, 1995, 'Clinical features of immunodeficiency in man', Human and Experimental Toxicology, vol. 14, pp. 95 - 97, http://dx.doi.org/10.1177/096032719501400120
    Journal articles | 1994
    Professor Samuel Norbert Breit
    Bennett S; Breit SN, 1994, 'Variables in the isolation and culture of human monocytes that are of particular relevance to studies of HIV', Journal of Leukocyte Biology, vol. 56, pp. 236 - 240, http://dx.doi.org/10.1002/jlb.56.3.236
    Journal articles | 1994
    Professor Samuel Norbert Breit
    Breit SN; Thornton SC; Penny R, 1994, 'Lung involvement in Scleroderma', Clinics in Dermatology, vol. 12, pp. 243 - 252, http://dx.doi.org/10.1016/S0738-081X(94)90328-X
    Journal articles | 1993
    Professor Samuel Norbert Breit
    Bennett S; Por SB; Cooley MA; Breit SN, 1993, 'In vitro replication dynamics of human culture-derived macrophages in a long term serum-free system', Journal of Immunology, vol. 150, pp. 2364 - 2371, https://www.ncbi.nlm.nih.gov/pubmed/7680690
    Journal articles | 1993
    Professor Samuel Norbert Breit
    Roberts CM; Foulcher E; Zaunders JJ; Bryant DH; Freund J; Cairns D; Penny R; Morgan GW; Breit SN, 1993, 'Radiation pneumonitis: A possible lymphocyte-mediated hypersensitivity reaction', Annals of Internal Medicine, vol. 118, pp. 696 - 700, http://dx.doi.org/10.7326/0003-4819-118-9-199305010-00006
    Journal articles | 1993
    Professor Samuel Norbert Breit
    Ma J; King N; Chen SL; Penny R; Breit SN, 1993, 'Antibody penetration of viable human cells. II. Anti-RNP antibodies binding to RNP antigen expressed on cell surface, which may mediate the antibody internalization', Clinical and Experimental Immunology, vol. 93, pp. 396 - 404, http://dx.doi.org/10.1111/j.1365-2249.1993.tb08191.x
    Journal articles | 1993
    Professor Samuel Norbert Breit
    Roberts CM; Cairns D; Bryant DH; Burke WMJ; Yeates M; Blake H; Penny R; Shelley L; Zaunders JJ; Breit SN, 1993, 'Changes in epithelial lining fluid albumin associated with smoking and interstitial lung disease', European Respiratory Journal, vol. 6, pp. 110 - 115
    Journal articles | 1993
    Professor Samuel Norbert Breit
    Breit SN, 1993, 'Bronchoalveolar Lavage Cellularity: The Distribution in Normal Volunteers', American Review of Respiratory Disease, vol. 147, pp. 1607 - 1607, http://dx.doi.org/10.1164/ajrccm/147.6_Pt_1.1607
    Journal articles | 1993
    Professor Samuel Norbert Breit
    Kuschner WG; Brown JK; Kane GC; Breit SN, 1993, 'Quantifying lymphocytes in bronchoalveolar lavage fluid [2]', Annals of Internal Medicine, vol. 119, pp. 1050 - 1051, http://dx.doi.org/10.7326/0003-4819-119-10-199311150-00019
    Journal articles | 1993
    Professor Samuel Norbert Breit
    Williams KM; Day RO; Breit SN, 1993, 'Biochemical actions and clinical pharmacology of anti-inflammatory drugs', Advances in Drug Research, vol. 24, pp. 121 - 198
    Journal articles | 1993
    Professor Samuel Norbert Breit
    Breit SN; Schwartz DA; Burmeister LF; Hunninghake GW, 1993, 'Bronchoalveolar lavage cellularity: The distribution in normal volunteers', American Review of Respiratory Disease, vol. 147, pp. 1607 - 1608, http://dx.doi.org/10.1164/ajrccm/147.6_pt_1.1607
    Journal articles | 1992
    Professor Samuel Norbert Breit
    Bennett S; Por SB; Stanley ER; Breit SN, 1992, 'Monocyte proliferation in a cytokine-freem serum-free system', Journal of Immunological Methods, vol. 153, pp. 201 - 212, http://dx.doi.org/10.1016/0022-1759(92)90323-L
    Journal articles | 1992
    Professor Samuel Norbert Breit
    Walsh BJ; Thornton SC; Penny R; Breit SN, 1992, 'Microplate reader-based quantitation of collagens', Analytical Biochemistry, vol. 203, pp. 187 - 190, http://dx.doi.org/10.1016/0003-2697(92)90301-M
    Journal articles | 1992
    Professor Samuel Norbert Breit
    Katelaris A; Penny R; Breit SN, 1992, 'Mitotic activity in the dermis of mice during graft versus host disease: The role of fibroblast replication in dermal fibrosis', Journal of Investigative Dermatology, vol. 99, pp. 779 - 783, http://dx.doi.org/10.1111/1523-1747.ep12614736
    Journal articles | 1992
    Professor Samuel Norbert Breit
    Thornton SC; Robbins JM; Penny R; Breit SN, 1992, 'Fibroblast growth factors in connective tissue disease associated interstitial lung disease', Clinical and Experimental Immunology, vol. 90, pp. 447 - 452, http://dx.doi.org/10.1111/j.1365-2249.1992.tb05866.x
    Journal articles | 1992
    Professor Samuel Norbert Breit
    Burke WMJ; Roberts CM; Bryant DH; Cairns D; Yeates M; Morgan GW; Martin BJ; Blake H; Penny R; Zaunders JJ; Breit SN, 1992, 'Smoking-induced changes in epithelial lining fluid volume, cell density and protein', European Respiratory Journal, vol. 5, pp. 780 - 784
    Journal articles | 1992
    Professor Samuel Norbert Breit
    Ma J; Walsh B; Chen SL; Penny R; Breit SN, 1992, 'Restoring antibody activity of a monoclonal anti-RNP antibody by dissociative HPLC demonstration of blocking antibody binding sites with antigen released from effete hybridoma cells', Journal of Immunological Methods, vol. 155, pp. 121 - 127, http://dx.doi.org/10.1016/0022-1759(92)90278-2
    Journal articles | 1992
    Professor Samuel Norbert Breit
    Cairns D; Shelley L; Burke WM; Bryant DH; Yeates M; Penny R; Breit SN, 1992, 'The differing patterns of interstitial lung involvement in connective tissue diseases.', Journal of Rheumatology, vol. 19, pp. 1089 - 1095
    Journal articles | 1992
    Professor Samuel Norbert Breit
    Ramsay SC; Yeates MG; Burke WMJ; Bryant DH; Morgan GW; Breit SN, 1992, 'Quantitative pulmonary gallium scanning in interstitial lung disease', European Journal of Nuclear Medicine, vol. 19, pp. 80 - 85, http://dx.doi.org/10.1007/BF00184121
    Journal articles | 1991
    Professor Samuel Norbert Breit
    Por SB; Cooley MA; Breit SN; Penny R; French PW, 1991, 'Antibodies to tubulin and actin bind to the surface of a human monocytic cell line, U937', Journal of Histochemistry and Cytochemistry, vol. 39, pp. 981 - 985, http://dx.doi.org/10.1177/39.7.1865114
    Journal articles | 1991
    Professor Samuel Norbert Breit
    THORNTON SC; POR SB; PENNY R; RICHTER M; SHELLEY L; BREIT SN, 1991, 'Identification of the major fibroblast growth factors released spontaneously in inflammatory arthritis as platelet derived growth factor and tumour necrosis factor‐alpha', Clinical & Experimental Immunology, vol. 86, pp. 79 - 86, http://dx.doi.org/10.1111/j.1365-2249.1991.tb05777.x
    Journal articles | 1991
    Professor Samuel Norbert Breit
    MA J; CHAPMAN GV; CHEN S; MELICK G; PENNY R; BREIT SN, 1991, 'Antibody penetration of viable human cells. I. Increased penetration of human lymphocytes by anti‐RNP IgG', Clinical & Experimental Immunology, vol. 84, pp. 83 - 91, http://dx.doi.org/10.1111/j.1365-2249.1991.tb08128.x
    Journal articles | 1991
    Professor Samuel Norbert Breit
    Cairns D; Shelley L; Burke WMJ; Bryant DH; Yeates M; Morgan GW; Penny R; Breit SN, 1991, 'Interstitial lung disease associated with connective tissue diseases: The use of statistical structure analysis in model development', American Review of Respiratory Disease, vol. 143, pp. 1235 - 1240, http://dx.doi.org/10.1164/ajrccm/143.6.1235
    Journal articles | 1990
    Professor Samuel Norbert Breit
    Thornton SC; Por SB; Walsh BJ; Penny R; Breit SN, 1990, 'Interaction of immune and connective tissue cells: I. The effect of lymphokines and monokines on fibroblast growth', Journal of Leukocyte Biology, vol. 47, pp. 312 - 320, http://dx.doi.org/10.1002/jlb.47.4.312
    Journal articles | 1990
    Professor Samuel Norbert Breit
    Gibson PG; Breit SN; Bryant DH, 1990, 'Hypoxia during bronchoalveolar lavage', Australian and New Zealand Journal of Medicine, vol. 20, pp. 39 - 43, http://dx.doi.org/10.1111/j.1445-5994.1990.tb00368.x
    Journal articles | 1989
    Professor Samuel Norbert Breit
    Breit SN; Cairns D; Szentirmay A; Callaghan T; Murray D; Wacher T; Gibson PG; Marks G; Bryant DH; Yeates M; Fernandez V; Penny R, 1989, 'The presence of Sjogren's syndrome is a major determinant of the pattern of interstitial lung disease in scleroderma and other connective tissue diseases', Journal of Rheumatology, vol. 16, pp. 1043 - 1049
    Journal articles | 1989
    Professor Samuel Norbert Breit
    Lloyd AR; Breit SN; Rozenberg MC, 1989, 'Recurrent fever in Sjogren's syndrome', Medical Journal of Australia, vol. 151, pp. 163 - 167, http://dx.doi.org/10.5694/j.1326-5377.1989.tb139604.x
    Journal articles | 1989
    Professor Samuel Norbert Breit
    Hicks C; Breit SN; Penny R, 1989, 'Response of microvascular endothelial cells to biological response modifiers', Immunology and Cell Biology, vol. 67, pp. 271 - 277, http://dx.doi.org/10.1038/icb.1989.41
    Journal articles | 1989
    Professor Samuel Norbert Breit
    GIBSON PG; ROBINSON BWS; McLENNAN G; BRYANT DH; BREIT SN, 1989, 'THE ROLE OF BRONCHOALVEOLAR LAVAGE IN THE ASSESSMENT OF DIFFUSE LUNG DISEASES', Australian and New Zealand Journal of Medicine, vol. 19, pp. 281 - 291, http://dx.doi.org/10.1111/j.1445-5994.1989.tb00263.x
    Journal articles | 1988
    Professor Samuel Norbert Breit
    Gibson PG; Bryant DH; Morgan GW; Yeates M; Fernandez V; Penny R; Breit SN, 1988, 'Radiation-induced lung injury: A hypersensitivity pneumonitis?', Annals of Internal Medicine, vol. 109, pp. 288 - 291, http://dx.doi.org/10.7326/0003-4819-109-4-288
    Journal articles | 1988
    Professor Samuel Norbert Breit
    Breit SN; Green I, 1988, 'Modulation of endothelial cell synthesis of von willebrand factor by mononuclear cell products', Pathophysiology of Haemostasis and Thrombosis, vol. 18, pp. 137 - 145, http://dx.doi.org/10.1159/000215797
    Journal articles | 1988
    Professor Samuel Norbert Breit
    Day RO; Breit SN; Cairns D; Champion GD, 1988, 'Aspects of the clinical trials of slow-acting anti-rheumatic drugs.', Agents and actions. Supplements, vol. 24, pp. 121 - 133, http://dx.doi.org/10.1007/978-3-0348-9160-8_11
    Journal articles | 1987
    Professor Samuel Norbert Breit
    Ma J; Chapman GV; Chen SL; Penny R; Breit SN, 1987, 'Flow cytometry with crystal violet to detect intracytoplasmic fluorescence in viable human lymphocytes demonstration of antibody entering living cells', Journal of Immunological Methods, vol. 104, pp. 195 - 200, http://dx.doi.org/10.1016/0022-1759(87)90504-7
    Journal articles | 1987
    Professor Samuel Norbert Breit
    Schrieber L; Manolios N; To SS; Geczy CL; Breit SN, 1987, 'Hypothesis: Lymphocyte trafficking in inflammatory rheumatic disease. A role for receptor mediated homing', Journal of Rheumatology, vol. 14, pp. 194 - 196
    Journal articles | 1985
    Professor Samuel Norbert Breit
    Breit SN; Wakefield D; Robinson JP; Luckhurst E; Clark P; Penny R, 1985, 'The role of α1-antitrypsin deficiency in the pathogenesis of immune disorders', Clinical Immunology and Immunopathology, vol. 35, pp. 363 - 380, http://dx.doi.org/10.1016/0090-1229(85)90097-2
    Journal articles | 1985
    Professor Samuel Norbert Breit
    Wakefield D; Easter J; Breit SN; Clark P; Penny R, 1985, 'α1 antitrypsin serum levels and phenotypes in patients with retinal vasculitis', British Journal of Ophthalmology, vol. 69, pp. 497 - 499, http://dx.doi.org/10.1136/bjo.69.7.497
    Journal articles | 1984
    Professor Samuel Norbert Breit
    Breit SN; MacLean P; Zaunders J; Robinson JP; Wakefield D; Cooper DA; Penny R, 1984, 'The effect of purified alpha 1 antitrypsin on PWM driven IgG synthesis', Journal of Clinical and Laboratory Immunology, vol. 14, pp. 191 - 193
    Journal articles | 1984
    Professor Samuel Norbert Breit
    Robinson P; Wakefield D; Breit SN; Easter JF; Penny R, 1984, 'Chemiluminescent response to pathogenic organisms: Normal human polymorphonuclear leukocytes', Infection and Immunity, vol. 43, pp. 744 - 752, http://dx.doi.org/10.1128/iai.43.2.744-752.1984
    Journal articles | 1983
    Professor Samuel Norbert Breit
    Breit SN; Clark P; Robinson JP; Luckhurst E; Dawkins RL; Penny R, 1983, 'Familial occurrence of α1-antitrypsin deficiency and Weber-Christian disease', Archives of Dermatology, vol. 119, pp. 198 - 202, http://dx.doi.org/10.1001/archderm.119.3.198
    Journal articles | 1983
    Professor Samuel Norbert Breit
    Breit SN; Robinson JP; Penny R, 1983, 'The effect of α1 antitrypsin on phagocyte function', Journal of Clinical and Laboratory Immunology, vol. 10, pp. 147 - 149
    Journal articles | 1983
    Professor Samuel Norbert Breit
    Breit SN; Luckhurst E; Penny R, 1983, 'The effect of α1 antitrypsin on the proliferative response of human peripheral blood lymphocytes', Journal of Immunology, vol. 130, pp. 681 - 686
    Journal articles | 1983
    Professor Samuel Norbert Breit
    Luckhurst E; Breit SN; McLean P; Penny R, 1983, 'Letter to the editor', Journal of Immunological Methods, vol. 58, pp. 271 - 272, http://dx.doi.org/10.1016/0022-1759(83)90283-1
    Journal articles | 1983
    Professor Samuel Norbert Breit
    Breit SN; Clark P; Robinson JP; Luckhurst E; Dawkins RL; Penny R, 1983, 'Familial Occurrence of α1-Antitrypsin Deficiency and Weber-Christian Disease', Archives of Dermatology, vol. 119, pp. 198 - 202, http://dx.doi.org/10.1001/archderm.1983.01650270016009
    Journal articles | 1982
    Professor Samuel Norbert Breit
    Clark P; Breit SN; Dawkins RL; Penny R, 1982, 'Genetic study of a family with two members with Weber Christian disease (panniculitis) and alpha 1 antitrypsin deficiency', American Journal of Medical Genetics, vol. 13, pp. 57 - 62, http://dx.doi.org/10.1002/ajmg.1320130110
    Journal articles | 1982
    Professor Samuel Norbert Breit
    Breit SN; Robinson JP; Luckhurst E; Clark P; Penny R, 1982, 'Immunoregulation by α1 antitrypsin', Journal of Clinical and Laboratory Immunology, vol. 7, pp. 127 - 131
    Journal articles | 1982
    Professor Samuel Norbert Breit
    Wakefield D; Breit SN; Clark P; Penny R, 1982, 'Immunogenetic factors in inflammatory eye disease. influence of hla–b27 and alpha1‐antitrypsin phenotypes on disease expression', Arthritis & Rheumatism, vol. 25, pp. 1431 - 1434, http://dx.doi.org/10.1002/art.1780251207
    Journal articles | 1980
    Professor Samuel Norbert Breit
    Breit SN; Penny R, 1980, 'The Role of α1 Protease Inhibitor (α1 Antitrypsin) in the Regulation of Immunologic and Inflammatory Reactions', Australian and New Zealand Journal of Medicine, vol. 10, pp. 449 - 453, http://dx.doi.org/10.1111/j.1445-5994.1980.tb04101.x
    Journal articles | 1975
    Professor Samuel Norbert Breit
    O'Rourke M; Breit S, 1975, 'Reply to Dr. Shaw and Dr. Christie', Australian and New Zealand Journal of Medicine, vol. 5, pp. 274 - 274, http://dx.doi.org/10.1111/j.1445-5994.1975.tb04583.x
    Journal articles | 1974
    Professor Samuel Norbert Breit
    Breit SN; O'Rourke MF, 1974, 'Comparison of Direct and Indirect Arterial Pressure Measurements in Hospitalised Patients', Australian and New Zealand Journal of Medicine, vol. 4, pp. 485 - 491, http://dx.doi.org/10.1111/j.1445-5994.1974.tb03222.x
  • Conference Abstracts | 2019
    Professor Samuel Norbert Breit
    Mahon KL; Lin H-M; Lee-Ng M; Stockler MR; Gurney H; Mallesara G; Briscoe KP; Marx GM; Higano CS; De Bono JS; Chi KN; Brown D; Breit SN; Horvath L, 2019, 'Clinical validation of circulating cytokines as markers of prognosis and response to docetaxel in men with metastatic castration-resistant prostate cancer.', in JOURNAL OF CLINICAL ONCOLOGY, AMER SOC CLINICAL ONCOLOGY, San Francisco, CA, Vol. 37, presented at ASCO-SITC Clinical Immuno-Oncology Symposium, San Francisco, CA, 28 February 2019 - 02 March 2019, http://dx.doi.org/10.1200/JCO.2019.37.7_suppl.230
    Conference Abstracts | 2019
    Professor Samuel Norbert Breit
    Mahon KL; Lin HM; Lee-Ng M; Cain D; Jacobs C; Stockler MR; Gurney H; Mallesara G; Briscoe K; Marx G; Higano CS; de Bono JS; Chi KN; Breit SN; Brown DA; Horvath LG, 2019, 'Company Profiles', in ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, WILEY, Vol. 15, pp. 33 - 33, http://dx.doi.org/10.1111/ajco.13198
    Conference Abstracts | 2018
    Professor Samuel Norbert Breit
    Golakani MH; Webster G; Li H; Breit SN; Brown DA, 2018, 'MIS416 ENHANCES RECOVERY FROM TRAUMATIC SPINAL CORD INJURY (SCI) IN MICE BY REGULATING THE INNATE IMMUNE RESPONSE', in JOURNAL OF NEUROTRAUMA, MARY ANN LIEBERT, INC, Toronto, CANADA, Vol. 35, pp. A10 - A11, presented at 3rd Joint Symposium of the International-and-National-Neurotrauma-Societies-and-AANS/CNS-Section on Neurotrauma and Critical Care, Toronto, CANADA, 11 August 2018 - 16 August 2018, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000441527400039&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2018
    Professor Samuel Norbert Breit
    Golakani MH; Webster G; Li H; Breit SN; Brown DA, 2018, 'MIS416 ENHANCES RECOVERY FROM TRAUMATIC SPINAL CORD INJURY (SCI) IN MICE BY REGULATING THE INNATE IMMUNE RESPONSE', in JOURNAL OF NEUROTRAUMA, MARY ANN LIEBERT, INC, Toronto, CANADA, Vol. 35, pp. A19 - A20, presented at 3rd Joint Symposium of the International-and-National-Neurotrauma-Societies-and-AANS/CNS-Section on Neurotrauma and Critical Care, Toronto, CANADA, 11 August 2018 - 16 August 2018, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000441527400060&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2016
    Professor Samuel Norbert Breit
    Mahon K; Lin HM; Spielman C; Lee-Ng M; Gurney H; Mallesara G; Stockler M; Briscoe K; Marx G; Breit SN; Brown DA; Horvath LG, 2016, 'Phase II trial of circulating cytokines as markers of docetaxel resistance in metastatic castrateresistant prostate cancer (mCRPC)', in BJU INTERNATIONAL, WILEY-BLACKWELL, Melbourne, AUSTRALIA, Vol. 118, pp. 21 - 21, presented at 17th Asia-Pacific Prostate Cancer Conference, Melbourne, AUSTRALIA, 31 August 2016 - 03 September 2016, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000381708200045&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2016
    Professor Samuel Norbert Breit
    Mahon K; Lin H-M; Spielman C; Lee-Ng M; Gurney H; Mallesara G; Stockler M; Briscoe K; Marx G; Breit SN; Brown D; Horvath L, 2016, 'PHASE II TRIAL OF CIRCULATING CYTOKINES AS MARKERS OF DOCETAXEL RESISTANCE IN METASTATIC CASTRATE-RESISTANT PROSTATE CANCER (mCRPC)', in ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, WILEY-BLACKWELL, Vol. 12, pp. 37 - 37, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000380004900039&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2015
    Professor Samuel Norbert Breit
    Watson B; Baxter A; Flood V; Schofield L; Zhang HP; Lee-Ng M; How-Chow D; Breit SN; Brown DA; Danta M, 2015, 'MACROPHAGE INHIBITORY CYTOKINE-1 (MIC-1) IS ASSOCIATED WITH DEGREE OF LIVER FIBROSIS IN HCV-RELATED LIVER DISEASE - THE MILC STUDY', in JOURNAL OF HEPATOLOGY, ELSEVIER SCIENCE BV, Vienna, AUSTRIA, Vol. 62, pp. S337 - S337, presented at 50th International Liver Congress of the European-Association-for-the-Study-of-the-Liver, Vienna, AUSTRIA, 22 April 2015 - 26 April 2015, http://dx.doi.org/10.1016/S0168-8278(15)30319-6
    Conference Abstracts | 2015
    Professor Samuel Norbert Breit
    Sasson SC; McGill K; Weinholt L; Carr A; Brown DA; Kelleher AD; Breit SN; Sewell WA, 2015, 'COMPARISON OF THE FREELITE (TM) SERUM FREE LIGHT CHAIN (SFLC) ASSAY WITH SERUM AND URINE ELECTROPHORESIS/IMMUNOFIXATION AND THE N LATEX FLC ASSAY', in INTERNAL MEDICINE JOURNAL, WILEY-BLACKWELL, Vol. 45, pp. 24 - 24, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000360834700077&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2015
    Professor Samuel Norbert Breit
    Barber D; Zhang HP; Lee-Ng M; Breit SN; Brown DA; Danta M, 2015, 'MIC1/GDF15 as a novel biomarker of colonic neoplasia', in JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, WILEY-BLACKWELL, Vol. 30, pp. 76 - 77, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000364505900153&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
    Conference Papers | 2014
    Professor Samuel Norbert Breit
    Mohammad M; Tsai VWW; Ruitenberg M; Hassanpour M; Li H; Hart P; Breit S; Sawchenko P; Brown D, 2014, 'CNS DCs modulate peripheral anti-CNS immunity', in JOURNAL OF NEUROIMMUNOLOGY, ELSEVIER SCIENCE BV, Mainz, GERMANY, pp. 82 - 82, presented at 12th International Congress of Neuroimmunology (ISNI), Mainz, GERMANY, 09 November 2014 - 13 November 2014, http://dx.doi.org/10.1016/j.jneuroim.2014.08.218
    Conference Abstracts | 2014
    Professor Samuel Norbert Breit
    Jiang J; Sachdev PS; Brown DA; Breit S; Crawford J; Smith E; Liu T; Trollor J; Wen W, 2014, 'Macrophage Inhibitory Cytokine-1 Is Linked to Brain Volume in Older Individuals [Poster Abstract 3194]', in Proceedings of the 20th Annual Meeting of the Organization for Human Brain Mapping (OHBM), 20th Annual Meeting of the Organization for Human Brain Mapping (OHBM), Hamburg, Germany, presented at 20th Annual Meeting of the Organization for Human Brain Mapping (OHBM), Hamburg, Germany, 08 June 2014 - 12 June 2014
    Conference Papers | 2013
    Professor Samuel Norbert Breit
    Horvath L; Chatfield MD; Lee-Ng M; Lin H-M; Castillo L; Breit SN; Brown DA; Molloy MP; Marx GM; Pavlakis N; Boyer MJ; Stockier MR; Wykes R; Henshall SM; Mahon KL, 2013, 'The role of macrophages in docetaxel (DTX) resistance in castrate-resistant prostate cancer (CRPC).', in JOURNAL OF CLINICAL ONCOLOGY, AMER SOC CLINICAL ONCOLOGY, Chicago, IL, presented at 49th Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), Chicago, IL, 31 May 2013 - 04 June 2013, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000335419605294&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2011
    Professor Samuel Norbert Breit
    Mahon K; Breit S; Brown D; Molloy M; Marx G; Boyer M; Stockler M; Henshall S; Sutherland R; Horvath L, 2011, 'Cytokines' profiles to predict chemotherapy outcome in castration resistant prostate cancer (CRPC)', in EUROPEAN JOURNAL OF CANCER, ELSEVIER SCI LTD, Brussels, BELGIUM, pp. S22 - S22, presented at 5th European-Organisation-for-Research-and-Treatment-of-Cancer (EORTC)/National-Cancer-Institute (NCI)/American-Society-of-Clinical-Oncology (ASCO) Annual Meeting on Molecular Markers in Cancer, Brussels, BELGIUM, 27 October 2011 - 29 October 2011, http://dx.doi.org/10.1016/S0959-8049(11)72671-5
    Conference Papers | 2008
    Professor Samuel Norbert Breit
    Phang JM; Harrop SJ; Wilk KE; Duff A; Breit SN; Curmi PMG, 2008, 'Structural studies of CLIC protein complexes', in ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, INT UNION CRYSTALLOGRAPHY, pp. C436 - C437, http://dx.doi.org/10.1107/S010876730808598X
    Conference Papers | 2006
    Professor Samuel Norbert Breit
    Hastak K; Agarwal M; Jackson MW; Breit SN; Stark GR; Agarwal ML, 2006, 'MIC-1 mediates p53-dependent protective arrest of cells in S-phase in response to starvation for DNA precursors', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000454608800300&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2005
    Professor Samuel Norbert Breit
    Curmi P; Littler D; Harrop S; Brown L; Pankhurst G; Tonini R; Mazzanti M; Breit S, 2005, 'Dramatic Structural Change in CLIC1: Globular Protein that Forms an Ion Channel', in ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, INT UNION CRYSTALLOGRAPHY, pp. C264 - C264, http://dx.doi.org/10.1107/S0108767305088719
    Conference Papers | 1999
    Professor Samuel Norbert Breit
    Singleton CB; Walker BD; Tie H; Wyse KR; Bursill JA; Valenzuela SM; Qui MR; Breit SN; Campbell TJ, 1999, 'Potential cellular mechanism for the antifibrillatory properties of fish oils: potent blockade of the Kv4.3 encoded transient outward current.', in European Heart Journal, W B Saunders Company Ltd, London, England, pp. 575 - 575, presented at European Society of Cardiology, Barcelona, Spain, -
    Conference Papers | 1998
    Professor Samuel Norbert Breit
    Walker BD; Singleton CB; Bursill JA; Wyse KR; Dwyer L; Qui MR; Valenzuela SM; Breit SN; Campbell TJ, 1998, 'Perhexiline maleate inhibits the rapidly activating cardiac delayed rectifier potassium channel (IKr) in rabbit ventricular myocytes and the human ether-a-go-go-related gene (HERG) potassium current', in Australian and New Zealand Journal of Medicine, Adis International Limited, Frenchs Forest, NSW, pp. 120 - 120, presented at Annual Scientific Meeting of Cardiac Soc. Aust. and N.Z, Perth, WA, 02 August 1998 - 05 August 1998
    Conference Presentations | 1983
    Professor Samuel Norbert Breit
    CLARKE P; BREIT SN; DAWKINS RL; PENNY R, 1983, 'ALPHA-1 ANTI-TRYPSIN DEFICIENCY AND WEBER CHRISTIAN DISEASE IN A FAMILY', Vol. 15, pp. 102 - 102, http://dx.doi.org/10.1016/S0031-3025(16)38212-5

Awards

Prof Breit’s seminal studies on the role and pathogenesis of MIC-1/GDF15 in cancer anorexia/cachexia and appetite regulation have been recognised by the NHMRC, by inclusion in the NHMRC Publication “Ten best projects 2011”.  The presentation speech describing these findings can be seen on http://youtu.be/iFdGHKnaZnc

Grants

Media