Professor Samuel Breit
Conjoint Professor

Professor Samuel Breit

MBBS, MD, FRACP, FRCPA

Medicine & Health
School of Clinical Medicine

Prof Breit is a Clinical Immunologist and Immunopathologist at St Vincent’s Hospital Sydney. As a Professor of Medicine at UNSW, he heads the Inflammation and Cytokine Biology Research Program at St Vincent’s Centre of Applied Medical Research. He has a career long interest in biomedical research,  has a long track record of project grant support and has published over 160 papers in peer-reviewed journals. Prof Breit’s group has spearheaded the investigation of 2 important molecules his research group first discovered and characterised over a decade ago: the intracellular chloride ion channel protein CLIC1 and the divergent TGF-b superfamily cytokine MIC-1/GDF15. With the latter molecule, through an evolving understanding of its biology and potential clinical application, Prof Breit has then been able to take his basic discoveries, from the bench to the bedside. These discoveries have been licensed to several major international companies where they will be applied to patient diagnosis and therapy: MIC-1/GDF15 diagnostic technology can be used in the diagnosis and management of cancer and cardiovascular disease, whilst therapeutic applications include the treatment of inflammatory diseases, obesity and cancer associated syndromes.

Prof Breit collaborates widely and maintains an active research program, involving post-doctoral scientist and PhD students, directed to understanding the biology, mode of action, disease association and therapeutic application of MIC-1/GDF15 and its receptor GFRAL. Currently his research is focused on understanding the central and peripheral mechanisms by which MIC-1/GDF15 causes anorexia, modulates metabolism and impacts inflammation and immunity

Prof Breit's publications and metrics can be found on https://scholar.google.com/citations?user=ouBIM90AAAAJ&hl=en

Phone
+61-2-8382-4952
Location
St Vincent's Hospital Sydney campus Level 8, Lowy Packer Building, 405 Liverpool St, Darlinghurst
  • Book Chapters | 2001
    Moore AG; Fairlie WD; Bauskin AR; Brown PK; Russell PK; Zhang H-P; Breit SN, 2001, 'MIC-1 and other TGF-β superfamily members in inflammation', in TGF-β and Related Cytokines in Inflammation, Birkhäuser Basel, pp. 1 - 9, http://dx.doi.org/10.1007/978-3-0348-8354-2_1
  • Journal articles | 2023
    Breit SN; Brown DA; Tsai VWW, 2023, 'GDF15 analogs as obesity therapeutics', Cell Metabolism, vol. 35, pp. 227 - 228, http://dx.doi.org/10.1016/j.cmet.2023.01.002
    Journal articles | 2021
    Breit SN; Brown DA; Tsai VWW, 2021, 'The GDF15-GFRAL Pathway in Health and Metabolic Disease: Friend or Foe?', Annual Review of Physiology, vol. 83, pp. 127 - 151, http://dx.doi.org/10.1146/annurev-physiol-022020-045449
    Journal articles | 2021
    Trend S; Leffler J; Jones AP; Cha L; Gorman S; Brown DA; Breit SN; Kermode AG; French MA; Ward NC; Hart PH, 2021, 'Associations of serum short-chain fatty acids with circulating immune cells and serum biomarkers in patients with multiple sclerosis', Scientific Reports, vol. 11, pp. 5244, http://dx.doi.org/10.1038/s41598-021-84881-8
    Journal articles | 2020
    Breit S; Ziegler J; Kelleher AD, 2020, 'Vale Ron Penny AO (1936-2019): pioneer of clinical immunology OBITUARY', CLINICAL & TRANSLATIONAL IMMUNOLOGY, vol. 9, http://dx.doi.org/10.1002/cti2.1119
    Journal articles | 2020
    Husaini Y; Tsai VWW; Manandhar R; Zhang HP; Lee-Ng KKM; Lebhar H; Marquis CP; Brown DA; Breit SN, 2020, 'Growth differentiation factor-15 slows the growth of murine prostate cancer by stimulating tumor immunity', PLoS ONE, vol. 15, pp. e0233846, http://dx.doi.org/10.1371/journal.pone.0233846
    Journal articles | 2020
    Kelleher A; Breit S; Levy JA, 2020, 'Professor Ronald Penny IN MEMORIAM', AIDS, vol. 34, pp. 959 - 960, http://dx.doi.org/10.1097/QAD.0000000000002520
    Journal articles | 2019
    Tsai VWW; Zhang HP; Manandhar R; Schofield P; Christ D; Lee-Ng KKM; Lebhar H; Marquis CP; Husaini Y; Brown DA; Breit SN, 2019, 'GDF15 mediates adiposity resistance through actions on GFRAL neurons in the hindbrain AP/NTS', International Journal of Obesity, vol. 43, pp. 2370 - 2380, http://dx.doi.org/10.1038/s41366-019-0365-5
    Journal articles | 2018
    Tsai VW; Zhang HP; Manandhar R; Lee-Ng KKM; Lebhar H; Marquis CP; Husaini Y; Sainsbury A; Brown DA; Breit SN, 2018, 'Treatment with the TGF-b superfamily cytokine MIC-1/GDF15 reduces the adiposity and corrects the metabolic dysfunction of mice with diet-induced obesity', International Journal of Obesity, vol. 42, pp. 561 - 571, http://dx.doi.org/10.1038/ijo.2017.258
    Journal articles | 2018
    Tsai VWW; Brown DA; Breit SN, 2018, 'Targeting the divergent TGFb superfamily cytokine MIC-1/GDF15 for therapy of anorexia/ cachexia syndromes', Current Opinion in Supportive and Palliative Care, vol. 12, pp. 404 - 409, http://dx.doi.org/10.1097/SPC.0000000000000384
    Journal articles | 2018
    Tsai VWW; Husaini Y; Sainsbury A; Brown DA; Breit SN, 2018, 'The MIC-1/GDF15-GFRAL Pathway in Energy Homeostasis: Implications for Obesity, Cachexia, and Other Associated Diseases', Cell Metabolism, vol. 28, pp. 353 - 368, http://dx.doi.org/10.1016/j.cmet.2018.07.018
    Journal articles | 2017
    Breit SN; Tsai VWW; Brown DA, 2017, 'Targeting Obesity and Cachexia: Identification of the GFRAL Receptor–MIC-1/GDF15 Pathway', Trends in Molecular Medicine, vol. 23, pp. 1065 - 1067, http://dx.doi.org/10.1016/j.molmed.2017.10.005
    Journal articles | 2017
    Danta M; Barber DA; Zhang HP; Lee-Ng M; Baumgart SWL; Tsai VWW; Husaini Y; Saxena M; Marquis CP; Errington W; Kerr S; Breit SN; Brown DA, 2017, 'Macrophage inhibitory cytokine-1/growth differentiation factor-15 as a predictor of colonic neoplasia', Alimentary Pharmacology and Therapeutics, vol. 46, pp. 347 - 354, http://dx.doi.org/10.1111/apt.14156
    Journal articles | 2017
    Domingo-Fernández R; Coll RC; Kearney J; Breit S; O’Neill LAJ, 2017, 'The intracellular chloride channel proteins CLIC1 and CLIC4 induce IL-1β transcription and activate the NLRP3 inflammasome', Journal of Biological Chemistry, vol. 292, pp. 12077 - 12087, http://dx.doi.org/10.1074/jbc.M117.797126
    Journal articles | 2017
    Low JK; Ambikairajah A; Shang K; Brown DA; Tsai VWW; Breit SN; Karl T, 2017, 'First behavioural characterisation of a knockout mouse model for the transforming growth factor (TGF)-β superfamily cytokine, MIC-1/GDF15', PLoS ONE, vol. 12, http://dx.doi.org/10.1371/journal.pone.0168416
    Journal articles | 2016
    Hare JE; Goodchild SC; Breit SN; Curmi PMG; Brown LJ, 2016, 'Interaction of Human Chloride Intracellular Channel Protein 1 (CLIC1) with Lipid Bilayers: A Fluorescence Study', Biochemistry, vol. 55, pp. 3825 - 3833, http://dx.doi.org/10.1021/acs.biochem.6b00080
    Journal articles | 2016
    Salao K; Jiang L; Li H; Tsai VWW; Husaini Y; Curmi PMG; Brown LJ; Brown DA; Breit SN, 2016, 'CLIC1 regulates dendritic cell antigen processing and presentation by modulating phagosome acidification and proteolysis', Biology Open, vol. 5, pp. 620 - 630, http://dx.doi.org/10.1242/bio.018119
    Journal articles | 2016
    Tsai VWW; Lin S; Brown DA; Salis A; Breit SN, 2016, 'Anorexia-cachexia and obesity treatment may be two sides of the same coin: Role of the TGF-b superfamily cytokine MIC-1/GDF15', International Journal of Obesity, vol. 40, pp. 193 - 197, http://dx.doi.org/10.1038/ijo.2015.242
    Journal articles | 2015
    2015, 'Abstracts of the 2(nd) Cancer Cachexia Conference, Montreal, Canada, 26-28 September 2014.', J Cachexia Sarcopenia Muscle, vol. 6, pp. 2 - 31, http://dx.doi.org/10.1002/jcsm.12004
    Journal articles | 2015
    Fisher OM; Levert-Mignon AJ; Lord SJ; Lee-Ng KKM; Botelho NK; Falkenback D; Thomas ML; Bobryshev YV; Whiteman DC; Brown DA; Breit SN; Lord RV, 2015, 'MIC-1/GDF15 in Barrett's oesophagus and oesophageal adenocarcinoma', British Journal of Cancer, vol. 112, pp. 1384 - 1391, http://dx.doi.org/10.1038/bjc.2015.100
    Journal articles | 2015
    Husaini Y; Lockwood GP; Nguyen TV; Tsai VWW; Mohammad MG; Russell PJ; Brown DA; Breit SN, 2015, 'Macrophage inhibitory cytokine-1 (MIC-1/GDF15) gene deletion promotes cancer growth in TRAMP prostate cancer prone mice', PLoS ONE, vol. 10, http://dx.doi.org/10.1371/journal.pone.0115189
    Journal articles | 2015
    Mahon KL; Lin HM; Castillo L; Lee BY; Lee-Ng M; Chatfield MD; Chiam K; Breit SN; Brown DA; Molloy MP; Marx GM; Pavlakis N; Boyer MJ; Stockler MR; Daly RJ; Henshall SM; Horvath LG, 2015, 'Cytokine profiling of docetaxel-resistant castration-resistant prostate cancer', British Journal of Cancer, vol. 112, pp. 1340 - 1348, http://dx.doi.org/10.1038/bjc.2015.74
    Journal articles | 2015
    Sasson SC; McGill K; Wienholt L; Carr A; Brown D; Kelleher AD; Breit SN; Sewell WA, 2015, 'Retrospective audit of the freeliteTM serum free light chain (SFLC) assay: testing patterns, concordance with serum and urine electrophoresis/immunofixation and correlation with the N latex FLC assay', Pathology, vol. 47, pp. S94 - S94, http://dx.doi.org/10.1097/01.pat.0000461601.28805.d5
    Journal articles | 2015
    Sasson SC; McGill K; Wienholt L; Carr A; Brown DA; Kelleher AD; Breit SN; Sewell WA, 2015, 'Comparison of the Freelite serum free light chain (SFLC) assay with serum and urine electrophoresis/immunofixation and the N Latex FLC assay', Pathology, vol. 47, pp. 564 - 569, http://dx.doi.org/10.1097/PAT.0000000000000316
    Journal articles | 2015
    Tsai VWW; Macia L; Feinle-Bisset C; Manandhar R; Astrup A; Raben A; Lorenzen JK; Schmidt PT; Wiklund F; Pedersen NL; Campbell L; Kriketos A; Xu A; Pengcheng Z; Jia W; Curmi PMG; Angstmann CN; Lee-Ng KKM; Zhang HP; Marquis CP; Husaini Y; Beglinger C; Lin S; Herzog H; Brown DA; Sainsbury A; Breit SN, 2015, 'Serum levels of human MIC-1/GDF15 vary in a diurnal pattern, do not display a profile suggestive of a satiety factor and are related to BMI', PLoS ONE, vol. 10, http://dx.doi.org/10.1371/journal.pone.0133362
    Journal articles | 2014
    Jiang L; Phang JM; Yu J; Harrop SJ; Sokolova AV; Duff AP; Wilk KE; Alkhamici H; Breit SN; Valenzuela SM; Brown LJ; Curmi PMG, 2014, 'CLIC proteins, ezrin, radixin, moesin and the coupling of membranes to the actin cytoskeleton: A smoking gun?', Biochimica et Biophysica Acta - Biomembranes, vol. 1838, pp. 643 - 657, http://dx.doi.org/10.1016/j.bbamem.2013.05.025
    Journal articles | 2014
    Mohammad MG; Tsai VWW; Ruitenberg MJ; Hassanpour M; Li H; Hart PH; Breit SN; Sawchenko PE; Brown DA, 2014, 'A forebrain-immune cell pathway for the maintenance of CNS immune tolerance', Neurology, Psychiatry and Brain Research, vol. 20, pp. 8 - 9, http://dx.doi.org/10.1016/j.npbr.2014.01.144
    Journal articles | 2014
    Mohammad MG; Tsai VWW; Ruitenberg MJ; Hassanpour M; Li H; Hart PH; Breit SN; Sawchenko PE; Brown DA, 2014, 'Immune cell trafficking from the brain maintains CNS immune tolerance', Journal of Clinical Investigation, vol. 124, pp. 1228 - 1241, http://dx.doi.org/10.1172/JCI71544
    Journal articles | 2014
    Tsai VW-W; Macia L; Manandhar R; Wiklund F; Grönberg H; Pedersen N; Lee-Ng M; Zhang HP; Brown D; Herzog H; Sainsbury A; Breit SN, 2014, 'Macrophage inhibitory cytokine 1 (MIC-1/GDF15), a novel regulator of body weight and appetite and a potential therapeutic for obesity', Obesity Research & Clinical Practice, vol. 8, pp. 105 - 105, http://dx.doi.org/10.1016/j.orcp.2014.10.191
    Journal articles | 2014
    Tsai VWW; Manandhar R; Jrøgensen SB; Lee-Ng KKM; Zhang HP; Marquis CP; Jiang L; Husaini Y; Lin S; Sainsbury A; Sawchenko PE; Brown DA; Breit SN, 2014, 'The anorectic actions of the TGFβ cytokine MIC-1/GDF15 require an intact brainstem area postrema and nucleus of the solitary tract', PLoS ONE, vol. 9, http://dx.doi.org/10.1371/journal.pone.0100370
    Journal articles | 2013
    Mohammad MG; Hassanpour M; Tsai VW-W; Li H; Ruitenberg MJ; Booth D; Serrats J; Hart PH; Symonds GP; Sawchenko P; Breit SN; Brown DA, 2013, 'Dendritic cells and multiple sclerosis: Disease, tolerance and therapy', International Journal of Molecular Sciences, vol. 14, pp. 547 - 562, http://dx.doi.org/10.3390/ijms14010547
    Journal articles | 2013
    Tsai VW-W; Macia L; Johnen H; Kuffner T; Manadhar R; Jorgensen ; Lee-Ng KKM; Hong PZ; Wu L; Marquis C; Jiang L; Husaini Y; Lin S; Herzog H; Brown DA; Sainsbury-Salis A; Breit SN, 2013, 'TGF-b Superfamily Cytokine MIC-1/GDF15 Is a Physiological Appetite and Body Weight Regulator', PLoS ONE, vol. 8, pp. e55174, http://dx.doi.org/10.1371/journal.pone.0055174
    Journal articles | 2012
    Breit SN; Carrero JJ; Tsai VWW; Yagoutifam N; Luo XW; Kuffner T; Bauskin AR; Wu L; Jiang L; Baranyi P; Heimburer O; Murikami M; Apple F; Marquis C; Macia L; Lin S; Sainsbury-Salis A; Herzog H; Law MG; Stenvinkel P; Brown DA, 2012, 'Macrophage inhibitory cytokine-1 (MIC-1/GDF15) and mortality in end-stage renal disease', Nephrology Dialysis Transplantation, vol. 27, pp. 70 - 75, http://dx.doi.org/10.1093/ndt/gfr575
    Journal articles | 2012
    Brown D; Hance KW; Rogers C; Sansbury ; Albert P; Murphy G; Laiyemo A; Wang Z; Cross A; Schatzkin A; Danta M; Srasu ; Amin J; Law MG; Breit SN; Lanza E; Brown , 2012, 'Serum Macrophage Inhibitory Cytokine-1 (MIC-1/GDF15): A Potential Screening Tool for the Prevention of Colon Cancer?', Cancer Epidemiology Biomarkers and Prevention, vol. 21, pp. 337 - 346, http://dx.doi.org/10.1158/1055-9965.EPI-11-0786
    Journal articles | 2012
    Husaini Y; Qiu MR; Lockwood G; Luo X; Shang P; Kuffner T; Tsai VW-W; Lele J; Russell PJ; Brown DA; Breit SN, 2012, 'Macrophage inhibitory cytokine-1 (MIC-1/GDF15) slows cancer development but increases metastases in TRAMP prostate cancer prone mice', PLoS One, vol. 7, pp. e43833, http://dx.doi.org/10.1371/journal.pone.0043833
    Journal articles | 2012
    Jiang L; Salao K; Li H; Rybicka JM; Yates R; Luo X; Shi XX; Kuffner T; Tsai VW-W; Husaini Y; Wu L; Brown DA; Grewal T; Brown LJ; Curmi PM; Breit SN, 2012, 'Intracellular chloride channel protein CLIC1 regulates macrophage function through modulation of phagosomal acidification', Journal of Cell Science, vol. 125, pp. 5479 - 5488, http://dx.doi.org/10.1242/jcs.110072
    Journal articles | 2012
    Johnen H; Kuffner T; Brown DA; Wu L; Stocker R; Breit SN, 2012, 'Increased expression of the TGF-b superfamily cytokine MIC-1/GDF15 protects ApoE(-/-) mice from the development of atherosclerosis', Cardiovascular Pathology, vol. 21, pp. 499 - 505, http://dx.doi.org/10.1016/j.carpath.2012.02.003
    Journal articles | 2012
    Macia L; Tsai VWW; Nguyen AD; Johnen H; Kuffner T; Shi Y; Lin S; Herzog H; Brown DA; Breit SN; Sainsbury-Salis A, 2012, 'Macrophage inhibitory cytokine 1 (MIC-1/GDF15) decreases food intake, body weight and improves glucose tolerance in mice on normal & obesogenic diets', PLoS One, vol. 7, pp. e34868, http://dx.doi.org/10.1371/journal.pone.0034868
    Journal articles | 2012
    Tsai VW-W; Husaini Y; Manandhar R; Lee-ng KKM; Hong PZ; Harriott K; Jiang L; Lin S; Sainsbury-Salis A; Brown DA; Breit SN, 2012, 'Anorexia/cachexia of chronic diseases: a role for the TGF-beta family cytokine MIC-1/GDF15', Journal of Cachexia, Sarcopenia and Muscle, vol. 3, pp. 239 - 243, http://dx.doi.org/10.1007/s13539-012-0082-6
    Journal articles | 2011
    Breit SN; Johnen H; Cook AD; Tsai VWW; Mohammad MG; Tamara K; Hong PZ; Marquis C; Lele J; Lockwood G; Lee-Ng M; Husaini Y; Wu L; Hamilton JA; Brown DA, 2011, 'The TGF-β superfamily cytokine, MIC-1/GDF15: A pleotrophic cytokine with roles in inflammation, cancer and metabolism', Growth Factors, vol. 29, pp. 187 - 195, http://dx.doi.org/10.3109/08977194.2011.607137
    Journal articles | 2011
    Brown DA; Tsai VWW; Mohammad MG; Tolhurst O; Breit SN; Sawchenko PE, 2011, 'CCAAT/enhancer binding protein-delta (C/EBPdelta) regulates Th17/Treg balance via an antigen presenting cell - interleukin-10 dependent mechanism in neuroinflammation', MULTIPLE SCLEROSIS JOURNAL, vol. 17, pp. S344 - S344, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209137301142&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 2011
    Goodchild SC; Angstmann CN; Breit SN; Curmi PM; Brown LJ, 2011, 'Transmembrane extension and oligomerization of the CLIC1 chloride intracellular channel protein upon membrane interaction', Biochemistry, vol. 50, pp. 10887 - 10897, http://dx.doi.org/10.1021/bi2012564
    Journal articles | 2011
    Tsai VWW; Mohammad MG; Tolhurst O; Breit SN; Sawchenko P; Brown DA, 2011, 'CCAAT/enhancer binding protein-CEBPD, expression by dendritic cells regulates CNS autoimmune inflammatory disease', The Journal of Neuroscience, vol. 31, pp. 17612 - 17621, http://dx.doi.org/10.1523/?JNEUROSCI.3449-11.2011
    Journal articles | 2010
    Bauskin AR; Jiang L; Luo X; Brown DA; Breit SN, 2010, 'The TGF-b superfamily cytokine MIC-1/GDF15: secretory mechanisms facilitate creation of latent stromal stores', Journal of Interferon and Cytokine Research, vol. 30, pp. 389 - 397, http://dx.doi.org/10.1089/jir.2009.0052
    Journal articles | 2010
    Goodchild SC; Howell MW; Littler DR; Mandyam RA; Sale KL; Mazzanti M; Breit SN; Curmi PMG; Brown LJ, 2010, 'Metamorphic response of the CLIC1 chloride intracellular ion channel protein upon membrane interaction', Biochemistry, vol. 49, pp. 5278 - 5289, http://dx.doi.org/10.1021/bi100111c
    Journal articles | 2010
    Littler DR; Harrop SJ; Goodchild SC; Phang J; Mynott AV; Jiang L; Valenzuela SM; Mazzanti M; Brown LJ; Breit SN; Curmi PM, 2010, 'The enigma of the CLIC proteins: Ion channels,redox proteins,enzymes,scaffolding proteins?', FEBS Letters, vol. 584, pp. 2093 - 2101, http://dx.doi.org/10.1016/j.febslet.2010.01.027
    Journal articles | 2010
    Roth P; Junker M; Tritschler I; Mittelbronn M; Dombrowski Y; Breit SN; Tabatabai G; Wick W; Weller M; Wischhusen J, 2010, 'GDF-15 contributes to proliferation and immune escape of malignant gliomas', Clinical Cancer Research, vol. 16, pp. 3559 - 3851, http://dx.doi.org/10.1158/1078-0432.CCR-10-0705
    Journal articles | 2009
    Brown DA; Lindmark F; Stattin P; Bälter K; Adami HO; Zheng SL; Xu J; Isaacs WB; Grönberg H; Breit SN; Wiklund FE, 2009, 'Macrophage inhibitory cytokine 1: A new prognostic marker in prostate cancer', Clinical Cancer Research, vol. 15, pp. 6658 - 6664, http://dx.doi.org/10.1158/1078-0432.CCR-08-3126
    Journal articles | 2009
    Goodchild SC; Howell M; Cordina NM; Littler DR; Breit SN; Curmi PM; Brown LJ, 2009, 'Oxidation promotes insertion of the CLIC1 chloride intracellular channel into the membrane', European Biophysics Journal With Biophysics Letters, vol. 39, pp. 129 - 138, http://dx.doi.org/10.1007/s00249-009-0450-0
    Journal articles | 2009
    Shnaper S; Desbaillets I; Brown DA; Murat A; Migliavacca E; Schluep M; Ostermann S; Hamou MF; Stupp R; Breit SN; De Tribolet N; Hegi ME, 2009, 'Elevated levels of MIC-1/GDF15 in the cerebrospinal fluid of patients are associated with glioblastoma and worse outcome', International Journal of Cancer, vol. 125, pp. 2624 - 2630, http://dx.doi.org/10.1002/ijc.24639
    Journal articles | 2009
    Zaunders J; Munier ML; Seddiki N; Pett SL; Ip S; Bailey M; Xu Y; Brown KJ; Dyer W; Kim MS; De Rose R; Kent SJ; Jiang L; Breit SN; Emery S; Cunningham AL; Cooper DA; Kelleher AD, 2009, 'High levels of human antigen-specific CD4+ T cells in peripheral blood revealed by stimulated coexpression of CD25 and CD134 (OX40)', Journal of Immunology, vol. 183, pp. 2827 - 2836, http://dx.doi.org/10.4049/jimmunol.0803548
    Journal articles | 2009
    Zhao L; Lee BY; Brown DA; Molloy M; Marx GM; Pavlakis N; Boyer MJ; Stockler M; Kaplan W; Breit SN; Sutherland RL; Henshall SM; Horvath LG, 2009, 'Identification of candidate biomarkers of therapeutic response to docetaxel by proteomic profiling', Cancer research, vol. 69, pp. 7696 - 7703, http://dx.doi.org/10.1158/0008-5472.CAN-08-4901
    Journal articles | 2008
    Littler DR; Luciani P; Pankhurst G; Mandyam R; Mazzanti M; Tanda S; Berryman M; Breit SN; Curmi PM; Brown LJ; Mynott AV; Harrop SJ, 2008, 'Comparison of vertebrate and invertebrate CLIC proteins: The crystal structures of Caenorhabditis elegans EXC-4 and Drosophila melanogaster DmCLIC', Proteins - Structure Function and Bioinformatics, vol. 71, pp. 364 - 378, http://dx.doi.org/10.1002/prot.21704
    Journal articles | 2007
    Brown DA; Moore JJ; Johnen H; Smeets TJ; Bauskin AR; Kuffner T; Weedon H; Milliken ST; Tak PP; Smith MD; Breit SN, 2007, 'Serum macrophage inhibitory cytokine 1 in rheumatoid arthritis - A potential marker of erosive joint destruction', Arthritis Care & Research, vol. 56, pp. 753 - 764, http://dx.doi.org/10.1002/art.22410
    Journal articles | 2007
    Cromer B; Gorman M; Hansen G; Adams J; Coggan M; Littler DR; Brown LJ; Mazzanti M; Breit SN; Curmi PM; Dulhunty A; Board P; Parker M, 2007, 'Structure of the Janus protein human CLIC2', Journal of Molecular Biology, vol. 374, pp. 719 - 731, http://dx.doi.org/10.1016/j.jmb.2007.09.041
    Journal articles | 2007
    Johnen H; Lin S; Kuffner T; Brown DA; Tsai V; Bauskin AR; Wu L; Pankhurst G; Jiang L; Junankar S; Hunter M; Fairlie WD; Lee NJ; Enriquez R; Baldock P; Corey E; Apple F; Murakami M; Lin E; Wang CC; During M; Sainsbury A; Herzog H; Breit SN, 2007, 'Tumor-induced anorexia and weight loss are mediated by the TGF-beta superfamily cytokine MIC-1', Nature Medicine, vol. 13, pp. 1333 - 1340, http://dx.doi.org/10.1038/nm1677
    Journal articles | 2007
    Selander KS; Brown DA; Sequeiros GB; Hunter M; Desmond R; Parpala T; Risteli J; Breit SN; Jukkola-Vuorinen A, 2007, 'Serum macrophage inhibitory cytokine-1 concentrations correlate with the presence of prostate cancer bone metastases', Cancer Epidemiology Biomarkers and Prevention, vol. 16, pp. 532 - 537, http://dx.doi.org/10.1158/1055-9965.EPI-06-0841
    Journal articles | 2006
    Agarwal MK; Hastak K; Jackson MW; Breit SN; Stark GR; Agarwal ML, 2006, 'Macrophage inhibitory cytokine 1 mediates a p53-dependent protective arrest in S phase in response to starvation for DNA precursors', Proceedings of the National Academy of Sciences of the United States of America, vol. 103, pp. 16278 - 16283, http://dx.doi.org/10.1073/pnas.0607210103
    Journal articles | 2006
    Bauskin AR; Brown DA; Kuffner T; Johnen H; Luo X; Hunter M; Breit SN, 2006, 'Role of macrophage inhibitory cytokine-1 in tumorigenesis and diagnosis of cancer', Cancer research, vol. 66, pp. 4983 - 4986, http://dx.doi.org/10.1158/0008-5472.CAN-05-4067
    Journal articles | 2006
    Koopmann J; Rosenzweig C; Zhang ZP; Canto M; Brown DA; Hunter M; Yeo CB; Chan DJ; Breit SN; Goggins M; Hunter M, 2006, 'Serum markers in patients with resectable pancreatic adenocarcinoma: Macrophage inhibitory cytokine 1 versus CA19-9', Clinical Cancer Research, vol. 12, pp. 442 - 446, http://dx.doi.org/10.1158/1078-0432.CCR-05-0564
    Journal articles | 2006
    Xu J; Kimball T; Lorenz J; Brown DA; Bauskin AR; Klevitsky R; Hewett T; Breit SN; Molkentin J, 2006, 'GDF15/MIC-1 functions as a protective and antihypertrophic factor released from the myocardium in association with SMAD protein activation', Circulation Research, vol. 98, pp. 342 - 350, http://dx.doi.org/10.1161/01.RES.0000202804.84885.d0
    Journal articles | 2005
    Weber F; Byrne S; Le S; Brown DA; Breit SN; Scolyer R; Halliday GM, 2005, 'Transforming growth factor-beta(1) immobilises dendritic cells within skin tumours and facilitates tumour escape from the immune system', Cancer Immunology and Immunotherapy, vol. 54, pp. 898 - 906, http://dx.doi.org/10.1007/s00262-004-0652-3
    Journal articles | 2004
    Koopmann J; Buckhaults P; Brown DA; Zahurak M; Sato N; Fukushima N; Sokoll L; Chan DW; Yeo C; Hruban R; Breit SN; Kinzler KW; Vogelstein B; Goggins M, 2004, 'Serum macrophage inhibitory cytokine 1 as a marker of pancreatic andother periampullary cancers', Clinical Cancer Research, vol. 10, pp. 2386 - 2392, http://dx.doi.org/10.1158/1078-0432.CCR-03-0165
    Journal articles | 2004
    Littler DR; Fairlie WD; Brown LJ; Pankhurst G; Pankhurst SM; Demaere MZ; Campbell TJ; Bauskin AR; Tonini R; Mazzanti M; Breit SN; Curmi PM; Harrop SJ, 2004, 'The intracellular chloride ion channel protein CLIC1 undergoes a redox-controlled structural transition', The Journal of Biological Chemistry, vol. 279, pp. 9298 - 9305, http://dx.doi.org/10.1074/jbc.M308444200
    Journal articles | 2004
    Marjono B; Manuelpillai U; Dimitriadis E; Salamonsen L; Breit S; Wallace E, 2004, '270.Macrophage inhibitory cytokine-1 at the maternal - fetal interface in early pregnancy', Reproduction, Fertility and Development, vol. 16, pp. 270 - 270, http://dx.doi.org/10.1071/srb04abs270
    Journal articles | 2003
    Brown DA; Ward RL; Buckhaults P; Liu T; Romans KE; Hawkins NJ; Bauskin AR; Kinzler KW; Vogelstein B; Breit SN, 2003, 'MIC 1 serum level and genotype: Associations with progress and prognosis of colorectal carcinoma', Clinical Cancer Research, vol. 9, pp. 2642 - 2650
    Journal articles | 2003
    Keelan JA; Wang K; Chaiworapongsa T; Romero R; Mitchell MD; Sato TA; Brown DA; Fairlie WD; Breit SN, 2003, 'Macrophase hihibitory cytokine 1 (MIC-1) in fetal membranes and amniotic fluid from pregnancies with and without preterm labour and premature rupture of membranes', Molecular Human Reproduction, vol. 9, pp. 535 - 540, http://dx.doi.org/10.1093/molehr/gag068
    Journal articles | 2003
    Liu T, 2003, 'Large-scale delineation of secreted protein biomarkers overexpressed in cancer tissue and serum', Proceedings of the National Academy of Sciences of the United States of America, vol. 100, pp. 3410 - 3415, http://dx.doi.org/10.1073/pnas.0530278100
    Journal articles | 2003
    Yang H; Filipovic Z; Brown DA; Breit SN; Vassilev LT, 2003, 'Macrophage inhibitory cytokine-1: a novel biomarker for p53 pathway activation', Molecular Cancer Therapeutics, vol. 2, pp. 1023 - 1029
    Journal articles | 2002
    Albertoni M; Shaw PH; Nozaki M; Sophie G; Tenan M; Hamou MF; Fairlie DW; Breit SN; Paralkar VM; De Tribolet N; Van Meir EG; Hegi ME, 2002, 'Anoxia induces macrophage inhibitory cytokine-1 (MIC-1) in glioblastoma cells independently of p53 and HIF-1', Oncogene, vol. 21, pp. 4212 - 4219, http://dx.doi.org/10.1038/sj.onc.1205610
    Journal articles | 2002
    Liu T, 2002, 'Concentration in plasma of macrophage inhibitory cytokine-1 and risk of cardiovascular events in women: a nested case-control study', Lancet, vol. 359, pp. 2159 - 2163, http://dx.doi.org/10.1016/S0140-6736(02)09093-1
    Journal articles | 2002
    Warton K; Tonini R; Fairlie WD; Matthews JM; Valenzuela SM; Qiu MR; Wu WM; Pankhurst S; Bauskin AR; Harrop SJ; Campbell TJ; Curmi PM; Breit SN; Mazzanti M, 2002, 'Recombinant CLIC1 (NCC27) assembles in lipid bilayers via a pH-dependent two-state process to form chloride ion channels with identical characteristics to those observed in Chinese Hamster Ovary cells expressing CLIC1', The Journal of Biological Chemistry, vol. 277, pp. 26003 - 26011, http://dx.doi.org/10.1074/jbc.M203666200
    Journal articles | 2001
    Christofi FL; Zhang H; Yu JG; Guzman J; Xue J; Kim M; Wang YZ; Cooke HJ, 2001, 'Differential gene expression of adenosine A1, A2a, A2b, and A3 receptors in the human enteric nervous system', Journal of Comparative Neurology, vol. 439, pp. 46 - 64, http://dx.doi.org/10.1002/cne.1334
    Journal articles | 2001
    Fairlie WD; Russell PK; Wu WM; Moore AG; Zhang H; Brown PK; Bauskin AR; Breit SN, 2001, 'Epitope mapping of the transforming growth factor-beta superfamily protein macrophage inhibitory cytokine-1 (MIC-1): indentification of at least five distinct epitope specificities', Biochemistry, vol. 40, pp. 65 - 73, http://dx.doi.org/10.1021/bi001064p
    Journal articles | 2001
    Harrop SJ; Demaere MZ; Fairlie WD; Reztsova T; Valenzuela SM; Mazzanti M; Tonini R; Qiu MR; Jankova L; Warton K; Bauskin AR; Wu WM; Pankhurst S; Campbell TJ; Breit SN; Curmi PM, 2001, 'Crystal structure of a soluble form of the Intracellular Chloride Ion Channel CLIC1 (NCC27) at 1.4-A resolution', The Journal of Biological Chemistry, vol. 276, pp. 44993 - 45000, http://dx.doi.org/10.1074/jbc.M107804200
    Journal articles | 2001
    Schober A; Bottner M; Strelau J; Kinscherf R; Bonaterra GA; Barth M; Schilling L; Fairlie WD; Breit SN; Unisicker K, 2001, 'Expression of growth differentiation factor-15/ macrophage inhibitory cytokine-1 (CDF-15/MIC-1) in the perinatal adult and injured rat brain', Journal of Comparative Neurology, vol. 439, pp. 32 - 45, http://dx.doi.org/10.1002/cne.1333
    Journal articles | 2000
    Moore AG; Brown DA; Fairlie WD; Bauskin AR; Brown PK; Munier MLC; Russell PK; Salamonsen LA; Wallace EM; Breit SN, 2000, 'The transforming growth factor-β superfamily cytokine macrophage inhibitory cytokine-1 is present in high concentrations in the serum of pregnant women', Journal of Clinical Endocrinology and Metabolism, vol. 85, pp. 4781 - 4788, http://dx.doi.org/10.1210/jc.85.12.4781
    Journal articles | 2000
    Tie H; Walker BD; Singleton CB; Valenzuela SM; Bursill JA; Wyse KR; Breit SN; Campbell TJ, 2000, 'Inhibiton of HERG potassium channels by the antimalarial agent halofantrine', British Journal of Pharmacology, vol. 130, pp. 1967 - 1975, http://dx.doi.org/10.1038/sj.bjp.0703470
    Journal articles | 2000
    Valenzuela SM; Mazzanti M; Tonini R; Qiu MR; Warton K; Musgrove EA; Campbell TJ; Breit SN, 2000, 'The nuclear chloride ion channel NCC27 is involved in regulation of the cell cycle', Journal of Physiology, vol. 529, pp. 541 - 552, http://dx.doi.org/10.1111/j.1469-7793.2000.00541.x
    Journal articles | 1995
    Morgan GJ; Breit SN, 1995, 'Radiation and the lung: a re-evaluation of the mechanisms mediating pulmonary injury', International Journal of Radiation Oncology and Biology Physics, vol. 31, pp. 361 - 369, http://dx.doi.org/10.1016/0360-3016(94)00477-3
    Journal articles | 1994
    Bennett S; Breit SN, 1994, 'Variables in the isolation and culture of human monocytes that are of particular relevance to studies of HIV', Journal of Leukocyte Biology, vol. 56, pp. 236 - 240, http://dx.doi.org/10.1002/jlb.56.3.236
    Journal articles | 1993
    Ma J; King N; Chen SL; Penny R; Breit SN, 1993, 'Antibody penetration of viable human cells. II. Anti-RNP antibodies binding to RNP antigen expressed on cell surface, which may mediate the antibody internalization', Clinical and Experimental Immunology, vol. 93, pp. 396 - 404, http://dx.doi.org/10.1111/j.1365-2249.1993.tb08191.x
    Journal articles | 1992
    Ma J; Walsh B; Chen SL; Penny R; Breit SN, 1992, 'Restoring antibody activity of a monoclonal anti-RNP antibody by dissociative HPLC demonstration of blocking antibody binding sites with antigen released from effete hybridoma cells', Journal of Immunological Methods, vol. 155, pp. 121 - 127, http://dx.doi.org/10.1016/0022-1759(92)90278-2
    Journal articles | 1991
    MA J; CHAPMAN GV; CHEN S; MELICK G; PENNY R; BREIT SN, 1991, 'Antibody penetration of viable human cells. I. Increased penetration of human lymphocytes by anti‐RNP IgG', Clinical & Experimental Immunology, vol. 84, pp. 83 - 91, http://dx.doi.org/10.1111/j.1365-2249.1991.tb08128.x
    Journal articles | 1987
    Ma J; Chapman GV; Chen SL; Penny R; Breit SN, 1987, 'Flow cytometry with crystal violet to detect intracytoplasmic fluorescence in viable human lymphocytes demonstration of antibody entering living cells', Journal of Immunological Methods, vol. 104, pp. 195 - 200, http://dx.doi.org/10.1016/0022-1759(87)90504-7
    Journal articles | 1985
    Wakefield D; Easter J; Breit SN; Clark P; Penny R, 1985, 'α1 antitrypsin serum levels and phenotypes in patients with retinal vasculitis', British Journal of Ophthalmology, vol. 69, pp. 497 - 499, http://dx.doi.org/10.1136/bjo.69.7.497
    Journal articles | 1984
    Robinson P; Wakefield D; Breit SN; Easter JF; Penny R, 1984, 'Chemiluminescent response to pathogenic organisms: Normal human polymorphonuclear leukocytes', Infection and Immunity, vol. 43, pp. 744 - 752, http://dx.doi.org/10.1128/iai.43.2.744-752.1984
    Journal articles | 1983
    Breit SN; Clark P; Robinson JP; Luckhurst E; Dawkins RL; Penny R, 1983, 'Familial occurrence of α1-antitrypsin deficiency and Weber-Christian disease', Archives of Dermatology, vol. 119, pp. 198 - 202, http://dx.doi.org/10.1001/archderm.119.3.198
  • Conference Abstracts | 2019
    Mahon KL; Lin H-M; Lee-Ng M; Stockler MR; Gurney H; Mallesara G; Briscoe KP; Marx GM; Higano CS; De Bono JS; Chi KN; Brown D; Breit SN; Horvath L, 2019, 'Clinical validation of circulating cytokines as markers of prognosis and response to docetaxel in men with metastatic castration-resistant prostate cancer.', in JOURNAL OF CLINICAL ONCOLOGY, AMER SOC CLINICAL ONCOLOGY, CA, San Francisco, Vol. 37, presented at ASCO-SITC Clinical Immuno-Oncology Symposium, CA, San Francisco, 28 February 2019 - 02 March 2019, http://dx.doi.org/10.1200/JCO.2019.37.7_suppl.230
    Conference Abstracts | 2019
    Mahon KL; Lin HM; Lee-Ng M; Cain D; Jacobs C; Stockler MR; Gurney H; Mallesara G; Briscoe K; Marx G; Higano CS; de Bono JS; Chi KN; Breit SN; Brown DA; Horvath LG, 2019, 'Company Profiles', in ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, WILEY, Vol. 15, pp. 33 - 33, http://dx.doi.org/10.1111/ajco.13198
    Conference Abstracts | 2016
    Mahon K; Lin H-M; Spielman C; Lee-Ng M; Gurney H; Mallesara G; Stockler M; Briscoe K; Marx G; Breit SN; Brown D; Horvath L, 2016, 'PHASE II TRIAL OF CIRCULATING CYTOKINES AS MARKERS OF DOCETAXEL RESISTANCE IN METASTATIC CASTRATE-RESISTANT PROSTATE CANCER (mCRPC)', in ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, WILEY-BLACKWELL, Vol. 12, pp. 37 - 37, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000380004900039&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2016
    Mahon K; Lin HM; Spielman C; Lee-Ng M; Gurney H; Mallesara G; Stockler M; Briscoe K; Marx G; Breit SN; Brown DA; Horvath LG, 2016, 'Phase II trial of circulating cytokines as markers of docetaxel resistance in metastatic castrateresistant prostate cancer (mCRPC)', in BJU INTERNATIONAL, WILEY-BLACKWELL, AUSTRALIA, Melbourne, Vol. 118, pp. 21 - 21, presented at 17th Asia-Pacific Prostate Cancer Conference, AUSTRALIA, Melbourne, 31 August 2016 - 03 September 2016, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000381708200045&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2015
    Sasson SC; McGill K; Weinholt L; Carr A; Brown DA; Kelleher AD; Breit SN; Sewell WA, 2015, 'COMPARISON OF THE FREELITE (TM) SERUM FREE LIGHT CHAIN (SFLC) ASSAY WITH SERUM AND URINE ELECTROPHORESIS/IMMUNOFIXATION AND THE N LATEX FLC ASSAY', in INTERNAL MEDICINE JOURNAL, WILEY-BLACKWELL, Vol. 45, pp. 24 - 24, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000360834700077&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2015
    Watson B; Baxter A; Flood V; Schofield L; Zhang HP; Lee-Ng M; How-Chow D; Breit SN; Brown DA; Danta M, 2015, 'MACROPHAGE INHIBITORY CYTOKINE-1 (MIC-1) IS ASSOCIATED WITH DEGREE OF LIVER FIBROSIS IN HCV-RELATED LIVER DISEASE - THE MILC STUDY', in JOURNAL OF HEPATOLOGY, ELSEVIER SCIENCE BV, AUSTRIA, Vienna, Vol. 62, pp. S337 - S337, presented at 50th International Liver Congress of the European-Association-for-the-Study-of-the-Liver, AUSTRIA, Vienna, 22 April 2015 - 26 April 2015, http://dx.doi.org/10.1016/S0168-8278(15)30319-6
    Conference Papers | 2014
    Mohammad M; Tsai VWW; Ruitenberg M; Hassanpour M; Li H; Hart P; Breit S; Sawchenko P; Brown D, 2014, 'CNS DCs modulate peripheral anti-CNS immunity', in JOURNAL OF NEUROIMMUNOLOGY, ELSEVIER SCIENCE BV, GERMANY, Mainz, pp. 82 - 82, presented at 12th International Congress of Neuroimmunology (ISNI), GERMANY, Mainz, 09 November 2014 - 13 November 2014, http://dx.doi.org/10.1016/j.jneuroim.2014.08.218

Prof Breit’s seminal studies on the role and pathogenesis of MIC-1/GDF15 in cancer anorexia/cachexia and appetite regulation have been recognised by the NHMRC, by inclusion in the NHMRC Publication “Ten best projects 2011”.  The presentation speech describing these findings can be seen on http://youtu.be/iFdGHKnaZnc

Growth differentiation factor 15 (GDF15; also called MIC-1) is a TGFb cytokine, now known to be a distant member of the glial derived neurotrophic factor (GDNF) family that binds to GDNF receptor-a like (GFRAL) and signals through its co-receptor Ret. GFRAL, identified at the GDF15 receptor 2 years ago, is highly localised to the hindbrain area postrema and nucleus of the solitary tract from where most of its anorexic actions and some other metabolic activity derive. Outside of this region and the testis, there is limited if any identified GFRAL expressing. Whilst GDF15 likely primary site of action is known, little is known about the mechanisms underlying its metabolic actions. Further, using robust transgenic animal models GDF15 has bioactivity in a number of different in vivo models including those of chronic inflammation and cancer, whose mechanisms have not been elucidated. Prof Breit is an international leader in study of this cytokine which his lab first cloned and characterised. Subsequently, his lab has been responsible for elucidation much of the biology of this cytokine, including its most important role as a metabolic regulator.

His lab is currently focussed elucidating the mechanisms by which GDF15 exerts its effects on appetite, metabolism, inflammation and immunity by both direct receptor and indirect non-receptor mediated actions by examining:

i) aspects of the basic biology of the GDF15-GFRAL pathway,

ii) the means by which the GDF15-GFRAL pathway regulates metabolism and

iii) the mechanisms by which the it influences selected immune and inflammatory responses.