Dr Sandhya   Clement
Lecturer

Dr Sandhya Clement

Engineering
Grad Sch: Biomedical Eng

Dr Sandhya Clement is a Research Associate at the Graduate School of Biomedical Engineering at The University of New South Wales. She completed her Bachelor of Engineering (Electronics and Communication) and Master of Technology (Optoelectronics and Laser Technology) at the International School of Photonics, Cochin University, India in 2008. She received her PhD degree in NanoBiophotonics from faculty of science and engineering, Macquarie University, Australia in April 2017. Her research focuses on spectroscopy and cancer nanotechnology with an emphasis on nanodrug formulation for therapeutical applications. Currently, she is leading a project in developing radiation-triggered nanodrugs for deep-seated cancers.

Phone
0405155133

Publications

  • Journal articles | 2021
    Dr Sandhya Clement
    Clement S; Guller A; Mahbub SB; Goldys EM, 2021, 'Oxygen-carrying polymer nanoconstructs for radiodynamic therapy of deep hypoxic malignant tumors', Biomedicines, vol. 9, http://dx.doi.org/10.3390/biomedicines9030322
    Journal articles | 2020
    Dr Sandhya Clement
    Deng W; McKelvey KJ; Guller A; Fayzullin A; Campbell JM; Clement S; Habibalahi A; Wargocka Z; Liang L; Shen C; Howell VM; Engel AF; Goldys EM, 2020, 'Application of Mitochondrially Targeted Nanoconstructs to Neoadjuvant X-ray-Induced Photodynamic Therapy for Rectal Cancer', ACS Central Science, vol. 6, pp. 715 - 726, http://dx.doi.org/10.1021/acscentsci.9b01121
    Journal articles | 2020
    Dr Sandhya Clement
    Clement S; Campbell JM; Deng W; Guller A; Nisar S; Liu G; Wilson BC; Goldys EM, 2020, 'Mechanisms for Tuning Engineered Nanomaterials to Enhance Radiation Therapy of Cancer', Advanced Science, vol. 7, http://dx.doi.org/10.1002/advs.202003584
    Journal articles | 2019
    Dr Sandhya Clement
    Islam K; Mahbub SB; Clement S; Guller A; Anwer AG; Goldys EM, 2019, 'Autofluorescence excitation-emission matrices as a quantitative tool for the assessment of meat quality', J Biophotonics, pp. e201900237 - e201900237, http://dx.doi.org/10.1002/jbio.201900237
    Journal articles | 2019
    Dr Sandhya Clement
    Feng S; Clement S; Zhu Y; Goldys EM; Inglis DW, 2019, 'Microfabricated needle for hydrogen peroxide detection', RSC Advances, vol. 9, pp. 18176 - 18181, http://dx.doi.org/10.1039/c9ra03028j
    Journal articles | 2018
    Dr Sandhya Clement
    Deng W; Chen W; Clement S; Guller A; Zhao Z; Engel A; Goldys EM, 2018, 'Controlled gene and drug release from a liposomal delivery platform triggered by X-ray radiation', Nat Commun, vol. 9, pp. 2713 - 2713, http://dx.doi.org/10.1038/s41467-018-05118-3
    Journal articles | 2018
    Dr Sandhya Clement
    Clement S; Chen W; Deng W; Goldys EM, 2018, 'X-ray radiation-induced and targeted photodynamic therapy with folic acid-conjugated biodegradable nanoconstructs', International Journal of Nanomedicine, vol. 13, pp. 3553 - 3570, http://dx.doi.org/10.2147/IJN.S164967
    Journal articles | 2017
    Dr Sandhya Clement
    Kautzka Z; Clement S; Goldys EM; Deng W, 2017, 'Light-triggered liposomal cargo delivery platform incorporating photosensitizers and gold nanoparticles for enhanced singlet oxygen generation and increased cytotoxicity', International Journal of Nanomedicine, vol. 12, pp. 969 - 977, http://dx.doi.org/10.2147/IJN.S126553
    Journal articles | 2017
    Dr Sandhya Clement
    Clement S; Chen W; Anwer AG; Goldys EM, 2017, 'Verteprofin conjugated to gold nanoparticles for fluorescent cellular bioimaging and X-ray mediated photodynamic therapy', Microchimica Acta, vol. 184, pp. 1765 - 1771, http://dx.doi.org/10.1007/s00604-017-2145-z
    Journal articles | 2017
    Dr Sandhya Clement
    Clement S; Gardner B; Razali WAW; Coleman VA; Jamting ÅK; Catchpoole HJ; Goldys EM; Herrmann J; Zvyagin A, 2017, 'Quantification of nanoparticle concentration in colloidal suspensions by a non-destructive optical method', Nanotechnology, vol. 28, http://dx.doi.org/10.1088/1361-6528/aa8d89
    Journal articles | 2017
    Dr Sandhya Clement
    Clement S; Sobhan M; Deng W; Camilleri E; Goldys EM, 2017, 'Nanoparticle-mediated singlet oxygen generation from photosensitizers', Journal of Photochemistry and Photobiology A: Chemistry, vol. 332, pp. 66 - 71, http://dx.doi.org/10.1016/j.jphotochem.2016.08.009
    Journal articles | 2016
    Dr Sandhya Clement
    Clement S; Deng W; Camilleri E; Wilson BC; Goldys EM, 2016, 'X-ray induced singlet oxygen generation by nanoparticle-photosensitizer conjugates for photodynamic therapy: Determination of singlet oxygen quantum yield', Scientific Reports, vol. 6, http://dx.doi.org/10.1038/srep19954
    Journal articles | 2015
    Dr Sandhya Clement
    Clement S; Deng W; Drozdowicz-Tomsia K; Liu D; Zachreson C; Goldys EM, 2015, 'Bright, water-soluble CeF3 photo-, cathodo-, and X-ray luminescent nanoparticles', Journal of Nanoparticle Research, vol. 17, http://dx.doi.org/10.1007/s11051-014-2833-0
    Journal articles | 2014
    Dr Sandhya Clement
    Ismail WZW; Liu D; Clement S; Coutts DW; Goldys EM; Dawes JM, 2014, 'Spectral and coherence signatures of threshold in random lasers', Journal of Optics (United Kingdom), vol. 16, http://dx.doi.org/10.1088/2040-8978/16/10/105008
    Journal articles | 2008
    Dr Sandhya Clement
    Jayasree V; Sandhya T; Radhakrishnan P, 2008, 'Non-invasive Studies on Age Related Parameters Using a Blood Volume Pulse Sensor', Measurement Science Review, vol. 8, http://dx.doi.org/10.2478/v10048-008-0020-0
  • Conference Papers | 2021
    Dr Sandhya Clement
    Deng W; McKelvey K; Guller A; Campbell J; Clement S; Habibalahi A; Goldys E, 2021, 'Application of mitochondrially targeted nanoconstructs to neo-adjuvant X-ray-induced photodynamic therapy for rectal cancer', in Mechanisms and Techniques in Photodynamic Therapy and Photobiomodulation, SPIE, presented at Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXX, 06 March 2021 - 12 March 2021, http://dx.doi.org/10.1117/12.2578073
    Conference Papers | 2021
    Dr Sandhya Clement
    Nisar S; Handley S; Clement S, 2021, 'Developing a novel biodegradable nanodrug platform for overcoming the challenges in treating pancreatic ductal adenocarcinoma (PDAC)', in Colloidal Nanoparticles for Biomedical Applications XVI, SPIE, presented at Colloidal Nanoparticles for Biomedical Applications XVI, 06 March 2021 - 12 March 2021, http://dx.doi.org/10.1117/12.2578964
    Conference Presentations | 2020
    Dr Sandhya Clement
    Clement S, 2020, 'Radiation activated Photodynamic Therapy an insight to treat deep-seated tumours with biocompatible nanodrug', presented at SPIE Bios, San Francisco USA
    Conference Papers | 2019
    Dr Sandhya Clement
    Goldys EM; Clement S; Deng W, 2019, 'Combining ionising radiation with nanoconstructs: towards new options in cancer therapy (Invited talk)', in Proc. SPIE. 10862, Molecular-Guided Surgery: Molecules, Devices, and Applications V, San Francisco USA, presented at SPIE BIOS, San Francisco USA, http://dx.doi.org/10.1117/12.2511905
    Conference Papers | 2019
    Dr Sandhya Clement
    Deng W; Chen W; Clement S; Guller A; Zhao Z; Engel A; Goldys E, 2019, 'Controlled drug release from a X-ray triggered liposomal delivery platform for colorectal cancer treatment (Conference Presentation)', in Proc. SPIE. 10860, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVIII, SPIE, San Francisco, USA, presented at SPIE BIOS, San Francisco, USA, http://dx.doi.org/10.1117/12.2506321
    Conference Papers | 2019
    Dr Sandhya Clement
    Clement S; Anwer A; Deng W; Wilson BC; Allen C; Goldys E, 2019, 'Nuclear targeted x-ray activated photodynamic therapy: a solution to treat pancreatic cancer', in Proc. SPIE. 10860, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVIII, San Francisco, USA, presented at SPIE BIOS, San Francisco, USA, http://dx.doi.org/10.1117/12.2508957
    Conference Presentations | 2019
    Dr Sandhya Clement
    Clement S; Anwer A; Deng W; Wilson BC; Goldys E, 2019, 'Targeted drug delivery for X-ray induced Photodynamic Therapy', presented at 10th International Nanomedicine Conference, Sydney Australia, 24 June 2019 - 26 June 2019
    Conference Presentations | 2019
    Dr Sandhya Clement
    Clement S; Deng W; Angel A; Goldys E, 2019, 'Using Mitochondria-Targeted Nanocarriers and Low Dose X-Rays for Combined Photodynamic Therapy (PDT) of Colorectal Cancer (Conference Presentation)', presented at 10th International Nanomedicine Conference, Sydney, Australila, 24 June 2019 - 26 June 2019
    Conference Presentations | 2019
    Dr Sandhya Clement
    Clement S, 2019, 'X-ray mediated Photodynamic therapy (PDT) using biodegradable nanoconstructs A new therapeutic paradigm for deep-seated cancers', presented at CONNECTIONS, UNSW ECAN, UNSW
    Conference Papers | 2018
    Dr Sandhya Clement
    Clement S; Chen W; Deng W; Goldys E, 2018, 'Biodegradable nanoconstructs for targeted deep tumour therapy', in Proc. SPIE. 10476, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVII, San Francisco, USA, presented at SPIE BIOS, San Francisco, USA, http://dx.doi.org/10.1117/12.2289254
    Conference Papers | 2018
    Dr Sandhya Clement
    Kautzka Z; Clement S; Goldys EM; Deng W, 2018, 'Light-triggered liposomal cargo delivery platform incorporating photosensitizers and gold nanoparticles for enhanced singlet oxygen generation and increased cytotoxicity', in Progress in Biomedical Optics and Imaging - Proceedings of SPIE, http://dx.doi.org/10.1117/12.2286552
    Conference Papers | 2018
    Dr Sandhya Clement
    Kautzka Z; Clement S; Goldys E; Deng W, 2018, 'Light-triggered liposomal cargo delivery platform incorporating photosensitizers and gold nanoparticles for enhanced singlet oxygen generation and increased cytotoxicity (Conference Presentation)', San Francisco, USA, presented at SPIE BIOS, San Francisco, USA, http://dx.doi.org/10.1117/12.2508957
    Conference Presentations | 2018
    Dr Sandhya Clement
    Deng W; Chen W; Clement S; Guller A; Zhao Z; Engel A; Goldys E, 2018, 'Controlled drug release from a liposomal delivery platform triggered by X-ray radiation', presented at Sydney Cancer Conference, Sydney, Australia, 11 October 2018 - 12 October 2018
    Conference Presentations | 2018
    Dr Sandhya Clement
    Islam K; Clement S; Mahbub SB; Plochner M; Anwer A; Goldys EM, 2018, 'Autofluorescence excitation – emission matrices and digital imaging as quantitative tools to determine meat quality', presented at SPIE BIOS, San Francisco, USA
    Conference Papers | 2016
    Dr Sandhya Clement
    Clement S; Deng W; Camilleri E; Wilson B; Goldys E, 2016, 'Towards photodynamic therapy with ionizing radiation: nanoparticle-mediated singlet oxygen generation (Conference Presentation)', in Parak WJ; Osinski M; Liang XJ (eds.), COLLOIDAL NANOPARTICLES FOR BIOMEDICAL APPLICATIONS XI, SPIE-INT SOC OPTICAL ENGINEERING, San Francisco, CA, presented at Conference on Colloidal Nanoparticles for Biomedical Applications XI, San Francisco, CA, 13 February 2016 - 15 February 2016, http://dx.doi.org/10.1117/12.2209206
    Conference Papers | 2016
    Dr Sandhya Clement
    Clement S; Deng W; Camilleri E; Wilson BC; Goldys E, 2016, 'Towards photodynamic therapy with ionising radiation: nanoparticle-mediated singlet oxygen generation (Conference Presentation)', in Proc. SPIE. 9722, Colloidal Nanoparticles for Biomedical Applications XI, San Francisco, USA, presented at BIOS SPIE Photonic West, San Francisco, USA, http://dx.doi.org/10.1117/12.2209206
    Conference Presentations | 2015
    Dr Sandhya Clement
    Clement S; Deng W; Camilleri E; Wilson BC; Goldys E, 2015, 'Scintillating Nanoparticles - Photosensitizer Conjugates towards X-ray activated Photo Dynamic Therapy (PDT)', presented at SPIE Micro+Nano Materials, Devices, and Systems, Sydney, Australia
    Conference Papers | 2009
    Dr Sandhya Clement
    Jayasree VK; Clement S; Radhakrishnan P, 2009, 'Studies on the effects of age and heart rate variation on second derivative of peripheral blood volume pulse using an optical plethysmograph', Kerala, presented at proceedings International conference on Opto electronics, Information and Communication technologies 2009 (ICOICT 2009), Kerala
    Conference Papers | 2008
    Dr Sandhya Clement
    Jayasree VK; Clement S; Radhakrishnan P, 2008, 'Photoplethysmographic assessment of Skin Vasomotor Reflex using the blood volume pulse measured at the fingertip', in Photonics 2008, Delhi, India, presented at Photonics 2008, Delhi, India
    Conference Papers | 2008
    Dr Sandhya Clement
    Clement S; Jayasree VK; Radhakrishnan P, 2008, 'Studies on the effects of air pollutants on the peripheral blood volume pulse using an optical plethysmograph', in Photonics 2008,, Delhi, India, presented at Photonics 2008,, Delhi, India
    Conference Papers | 2008
    Dr Sandhya Clement
    Clement S; Jayasree VK; Radhakrishnan P, 2008, 'Statistical signal processing approach to assess Bilateral symmetry of Blood volume pulse recorded at the fingertip using an optooelectronic configuration', in All India seminar On Emerging trends in information and communication technology, Electronics and Communication Engineering Division, The Institute of Engineers (India), Cochin, India, presented at Published in proceedings All India seminar On Emerging trends in information and communication technology, Cochin, India

Awards

  • Won Best Poster Award for the Poster presented in Center for Nanoscale Biophotonics (CNBP) conference Melbourne, Victoria, Australia (December 2018)
  • Selected to be one of the 35 early career researcher all over Australia to attend a workshop "Mentoring and Guidance in Careers (MAGIC) workshop for early career female or gender diverse researchers in mathematics and physics” held at University house, ANU Canberra (29/10/2018 to 02/11/2018)
  • Received Award for Excellence in Sessional Teaching, Department of Physics & Astronomy, Faculty of   Science and Engineering, Macquarie University 2016.
  • Won a second prize for the best poster presented at the MQ BioFocus research Centre Conference Sydney,NSW, Australia (December 2014). 
  • Won First Rank in M Tech -Optoelectronics and Laser Technology from Cochin University of Science and Technology, India. 
  • Won PSI (Photonic Society of India) Award-2008 for academic excellence, M Tech 2006-2008.

Grants

  • Sydney Vital travel grant round 5 2019, $3000, sole applicant
  • Sydney Vital Seed funding grant (2018-2019), $25,000, Chief Investigator/sole applicant
  • Post graduate research fund/ travel grant, Macquarie University (2015), $4,800, sole applicant
  • Higher Degree Research Fund, Macquarie University (2012-2016), $12,700, sole applicant.
  • International Macquarie University Research Excellence Scholarship – iMQRES (2012-2016), $193,450, sole applicant.

Media