Dr Sarah Hancock

PhD - University of Wollongong (2016)
BSc(Hons) - University of Wollongong (2010)

Medicine & Health

School of Biomedical Sciences

E-mail

sarah.hancock@unsw.edu.au

Journal articles | 2023

Hancock SE; Ding E; Beves EJ; Mitchell T; Turner N, 2023, 'FACS-assisted single-cell lipidome analysis of phosphatidylcholines and sphingomyelins in cells of different lineages', Journal of Lipid Research, 64, pp. 100341, http://dx.doi.org/10.1016/j.jlr.2023.100341

Journal articles | 2022

Brandon AE; Small L; Nguyen TV; Suryana E; Gong H; Yassmin C; Hancock SE; Pulpitel T; Stonehouse S; Prescott L; Kebede MA; Yau B; Quek LE; Kowalski GM; Bruce CR; Turner N; Cooney GJ, 2022, 'Insulin sensitivity is preserved in mice made obese by feeding a high starch diet', eLife, 11, http://dx.doi.org/10.7554/eLife.79250

Journal articles | 2022

Hancock SE; Friedrich MG; Mitchell TW; Truscott RJW; Else PL, 2022, 'Changes in Phospholipid Composition of the Human Cerebellum and Motor Cortex during Normal Ageing', Nutrients, 14, http://dx.doi.org/10.3390/nu14122495

Journal articles | 2022

Phillips GR; Hancock SE; Jenner AM; McLean C; Newell KA; Mitchell TW, 2022, 'Phospholipid Profiles Are Selectively Altered in the Putamen and White Frontal Cortex of Huntington’s Disease', Nutrients, 14, http://dx.doi.org/10.3390/nu14102086

Journal articles | 2022

Phillips GR; Saville JT; Hancock SE; Brown SHJ; Jenner AM; Mclean C; Fuller M; Newell KA; Mitchell TW, 2022, 'The long and the short of Huntington's disease: how the sphingolipid profile is shifted in the caudate of advanced clinical cases', Brain Communications, 4, http://dx.doi.org/10.1093/braincomms/fcab303

Journal articles | 2021

Friedrich MG; Skora A; Hancock SE; Mitchell TW; Else PL; Truscott RJW, 2021, 'Tau is truncated in five regions of the normal adult human brain', International Journal of Molecular Sciences, 22, http://dx.doi.org/10.3390/ijms22073521

Journal articles | 2021

Jayashankar V; Selwan E; Hancock SE; Verlande A; Goodson MO; Eckenstein KH; Milinkeviciute G; Hoover BM; Chen B; Fleischman AG; Cramer KS; Hanessian S; Masri S; Turner N; Edinger AL, 2021, 'Drug-like sphingolipid SH-BC-893 opposes ceramide-induced mitochondrial fission and corrects diet-induced obesity', EMBO Molecular Medicine, 13, http://dx.doi.org/10.15252/emmm.202013086

Journal articles | 2021

Li YE; Wang Y; Du X; Zhang T; Mak H; Hancock SE; McEwen H; Pandzic E; Whan RM; Aw YC; Lukmantara IE; Yuan Y; Dong X; Don A; Turner N; Qi S; Yang H, 2021, 'TMEM41B and VMP1 are scramblases and regulate the distribution of cholesterol and phosphatidylserine', Journal of Cell Biology, 220, http://dx.doi.org/10.1083/jcb.202103105

Journal articles | 2021

Nguyen GTH; Bennett JL; Liu S; Hancock SE; Winter DL; Glover DJ; Donald WA, 2021, 'Multiplexed Screening of Thousands of Natural Products for Protein–Ligand Binding in Native Mass Spectrometry', Journal of the American Chemical Society, 143, pp. 21379 - 21387, http://dx.doi.org/10.1021/jacs.1c10408

Journal articles | 2021

Wang Q; Guan YF; Hancock SE; Wahi K; van Geldermalsen M; Zhang BK; Pang A; Nagarajah R; Mak B; Freidman N; Horvath LG; Turner N; Holst J, 2021, 'Inhibition of guanosine monophosphate synthetase (GMPS) blocks glutamine metabolism and prostate cancer growth', Journal of Pathology, 254, pp. 135 - 146, http://dx.doi.org/10.1002/path.5665

Journal articles | 2020

Du X; Zhou L; Aw YC; Mak HY; Xu Y; Rae J; Wang W; Zadoorian A; Hancock SE; Osborne B; Chen X; Wu JW; Turner N; Parton RG; Li P; Yang H, 2020, 'ORP5 localizes to ER-lipid droplet contacts and regulates the level of PI(4)P on lipid droplets', Journal of Cell Biology, 219, http://dx.doi.org/10.1083/jcb.201905162

Journal articles | 2020

Phillips GR; Hancock SE; Brown SHJ; Jenner AM; Kreilaus F; Newell KA; Mitchell TW, 2020, 'Cholesteryl ester levels are elevated in the caudate and putamen of Huntington’s disease patients', Scientific Reports, 10, http://dx.doi.org/10.1038/s41598-020-76973-8

Journal articles | 2020

Wang Q; Guan Y; Hancock S; Wahi K; van Geldermalsen M; Zhang B; Pang A; Nagarajah R; Mak B; Horvath L; Turner N; Holst J, 2020, 'Inhibition of guanosine monophosphate synthetase (GMPS) blocks glutamine metabolism and prostate cancer growth in vitro and in vivo', , http://dx.doi.org/10.1101/2020.09.07.286997

Journal articles | 2019

Hancock SE; Maccarone AT; Poad BLJ; Trevitt AJ; Mitchell TW; Blanksby SJ, 2019, 'Reaction of ionised steryl esters with ozone in the gas phase', Chemistry and Physics of Lipids, 221, pp. 198 - 206, http://dx.doi.org/10.1016/j.chemphyslip.2018.12.013

Journal articles | 2019

Hancock SE; Poad BLJ; Willcox MDP; Blanksby SJ; Mitchell TW, 2019, 'Analytical separations for lipids in complex, nonpolar lipidomes using differential mobility spectrometry', Journal of Lipid Research, 60, pp. 1968 - 1978, http://dx.doi.org/10.1194/jlr.D094854

Journal articles | 2019

Liu M; Hancock SE; Sultani G; Wilkins BP; Ding E; Osborne B; Quek LE; Turner N, 2019, 'Snail-overexpression induces epithelialmesenchymal transition and metabolic reprogramming in human pancreatic ductal adenocarcinoma and non-tumorigenic ductal cells', Journal of Clinical Medicine, 8, http://dx.doi.org/10.3390/jcm8060822

Journal articles | 2019

Schömel N; Hancock SE; Gruber L; Olzomer EM; Byrne FL; Shah D; Hoehn KL; Turner N; Grösch S; Geisslinger G; Wegner MS, 2019, 'UGCG influences glutamine metabolism of breast cancer cells', Scientific Reports, 9, pp. 15665, http://dx.doi.org/10.1038/s41598-019-52169-7

Journal articles | 2018

Hancock SE; Ailuri R; Marshall DL; Brown SHJ; Saville JT; Narreddula VR; Boase NR; Poad BLJ; Trevitt AJ; Willcox MDP; Kelso MJ; Mitchell TW; Blanksby SJ, 2018, 'Mass spectrometry-directed structure elucidation and total synthesis of ultra-long chain (O-acyl)-ω-hydroxy fatty acids', Journal of Lipid Research, 59, pp. 1510 - 1518, http://dx.doi.org/10.1194/jlr.M086702

Journal articles | 2017

Hancock SE; Friedrich MG; Mitchell TW; Truscott RJW; Else PL, 2017, 'The phospholipid composition of the human entorhinal cortex remains relatively stable over 80 years of adult aging', GeroScience, 39, pp. 73 - 82, http://dx.doi.org/10.1007/s11357-017-9961-2

Journal articles | 2017

Hancock SE; Poad BLJ; Batarseh A; Abbott SK; Mitchell TW, 2017, 'Advances and unresolved challenges in the structural characterization of isomeric lipids', Analytical Biochemistry, 524, pp. 45 - 55, http://dx.doi.org/10.1016/j.ab.2016.09.014

Journal articles | 2016

Cornely R; Pollock AH; Rentero C; Norris SE; Alvarez-Guaita A; Grewal T; Mitchell T; Enrich C; Moss SE; Parton RG; Rossy J; Gaus K, 2016, 'Annexin A6 regulates interleukin-2-mediated T-cell proliferation', Immunology and Cell Biology, 94, pp. 543 - 553, http://dx.doi.org/10.1038/icb.2016.15

Journal articles | 2016

Friedrich MG; Hancock SE; Raftery MJ; Truscott RJW, 2016, 'Isoaspartic acid is present at specific sites in myelin basic protein from multiple sclerosis patients: Could this represent a trigger for disease onset?', Acta Neuropathologica Communications, 4, pp. 83, http://dx.doi.org/10.1186/s40478-016-0348-x

Journal articles | 2016

Pollock AH; Tedla N; Hancock SE; Cornely R; Mitchell TW; Yang Z; Kockx M; Parton RG; Rossy J; Gaus K, 2016, 'Prolonged intake of dietary lipids alters membrane structure and T cell responses in LDLr^-/- mice', Journal of Immunology, 196, pp. 3993 - 4002, http://dx.doi.org/10.4049/jimmunol.1501261

Journal articles | 2015

Cortie CH; Hulbert AJ; Hancock SE; Mitchell TW; McAndrew D; Else PL, 2015, 'Of mice, pigs and humans: An analysis of mitochondrial phospholipids from mammals with very different maximal lifespans', Experimental Gerontology, 70, pp. 135 - 143, http://dx.doi.org/10.1016/j.exger.2015.08.011

Journal articles | 2015

Hancock SE; Friedrich MG; Mitchell TW; Truscott RJW; Else PL, 2015, 'Decreases in Phospholipids Containing Adrenic and Arachidonic Acids Occur in the Human Hippocampus over the Adult Lifespan', Lipids, 50, pp. 861 - 872, http://dx.doi.org/10.1007/s11745-015-4030-z

Journal articles | 2015

Norris SE; Friedrich MG; Mitchell TW; Truscott RJW; Else PL, 2015, 'Human prefrontal cortex phospholipids containing docosahexaenoic acid increase during normal adult aging, whereas those containing arachidonic acid decrease', Neurobiology of Aging, 36, pp. 1659 - 1669, http://dx.doi.org/10.1016/j.neurobiolaging.2015.01.002

Journal articles | 2012

Norris SE; Mitchell TW; Else PL, 2012, 'Phospholipid peroxidation: Lack of effect of fatty acid pairing', Lipids, 47, pp. 451 - 460, http://dx.doi.org/10.1007/s11745-012-3654-5
Preprints | 2022

Brandon A; Small L; Nguyen T-V; Suryana E; Gong H; Yassmin C; Hancock S; Pulpitel T; Stonehouse S; Prescott L; Kebede M; Yau B; Quek L-E; Kowalski G; Bruce C; Turner N; Cooney G, 2022, Insulin sensitivity is preserved in mice made obese by feeding a high starch diet, , http://dx.doi.org/10.1101/2022.05.25.493410

Preprints | 2022

Hancock S; Ding E; Beves EJ; Mitchell T; Turner N, 2022, FACS-assisted single-cell lipidome analysis of phosphatidylcholines and sphingomyelins, , http://dx.doi.org/10.1101/2022.02.15.479799

Conference Papers | 2021

Choong L; Hancock S; Lising J; Ding E; Turner N, 2021, 'The role of altered lipid metabolism in chemoresistant pancreatic ductal adenocarcinoma', in ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, WILEY, pp. 41 - 42, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000693805000076&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Papers | 2021

Hancock S; Ding E; Mitchell T; Turner N, 2021, 'High-throughput single-cell lipidomics of prostate cancer cells', in ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, WILEY, pp. 40 - 40, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000693805000072&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Preprints | 2021

Nguyen G; Bennett J; Liu S; Hancock S; Winter D; Glover D; Donald W, 2021, Multiplexed screening of thousands of natural products for protein-ligand binding in native mass spectrometry, , http://dx.doi.org/10.26434/chemrxiv-2021-sc39c

Preprints | 2021

Nguyen G; Bennett J; Liu S; Hancock S; Winter D; Glover D; Donald W, 2021, Multiplexed screening of thousands of natural products for protein-ligand binding in native mass spectrometry, , http://dx.doi.org/10.26434/chemrxiv-2021-sc39c-v2

Preprints | 2021

Nguyen G; Bennett J; Liu S; Hancock S; Winter D; Glover D; Donald W, 2021, Multiplexed screening of thousands of natural products for protein-ligand binding in native mass spectrometry, , http://dx.doi.org/10.33774/chemrxiv-2021-sc39c

Preprints | 2021

Nguyen G; Bennett J; Liu S; Hancock S; Winter D; Glover D; Donald W, 2021, Multiplexed screening of thousands of natural products for protein-ligand binding in native mass spectrometry, , http://dx.doi.org/10.33774/chemrxiv-2021-sc39c-v2

Conference Papers | 2017

Friedrich M; Hancock S; Raftery M; Truscott RJW, 2017, 'Racemisation of Long-Lived Proteins in Human Myelin: Implications for Multiple Sclerosis', in MULTIPLE SCLEROSIS JOURNAL, SAGE PUBLICATIONS LTD, AUSTRALIA, MS Res Australia, Sydney, pp. NP3 - NP3, presented at Progress in MS Research Conference, AUSTRALIA, MS Res Australia, Sydney, 11 October 2017 - 13 October 2017, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000414783200008&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Young Investigator Project grant funded by Cure Cancer Australia through Cancer Australia's Priority-driven Collaborative Cancer Research Scheme: Understanding metabolite heterogeneity in pancreatic ductal adenocarcinoma, and its role in adaptive metabolic reprogramming during chemotherapy treatment. (2019)

Mark Wainwright Analytical Centre Research Grant: Optimisation of a mass spectrometry imaging method to detect small polar metabolites in pancreatic cancer tissue. (2019)

Tour de Cure Pioneering Grant. Unmasking metabolic changes that facilitate pancreatic cancer growth (2019)

Best Young Scientist talk – 9th International Singapore Lipid Symposium (USD$1000; 2021)
Apte Scholarship, UNSW Faculty of Medicine ($20,0000; 2021)
UNSW Faculty of Medicine Award for Research Excellence (Early Career Academic Staff; 2019)
UNSW SoMS Paper of the Month (August 2019)
Metabolomics Society Early Career Travel Award (USD$500; 2019)
Translational Cancer Research Institute Conference and Professional Development Grant ($2500; 2019)
Helmsley Scholarship (2017)
Australian Postgraduate Award (2011-2015)
Bomaderry Rotary Club Scholarship (2011)
UOW Faculty of Health and Behavioural Sciences Deans Merit List: (2010, 2007)
UOW Faculty of Health and Behavioural Sciences Research Committee Research Scholarship (2010)
UOW Faculty of Health and Behavioural Sciences Research Committee Summer Research Scholarship (2009)

Cure Cancer Australia (2019)

The Smith Family iTrack Youth Mentor (2016-present)

My Research Supervision

Honours students

Laura Choong "Examination of Altered Lipid Metabolism in Gemcitabine Resistant Pancreatic Ductal Adenocarcinoma"
Danny Nguyen "Investigating the changes in circulating lipids and metabolites following bariatric surgery"

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