My research program develops human stem cell and organoid systems to understand disease mechanisms, predict therapeutic response and advance regenerative treatments for chronic airway disease.

A central focus of my work is the development of patient-derived epithelial organoid models that enable direct investigation of disease biology in human tissue. My laboratory builds and studies organoid systems derived from airway, gut, liver and other epithelial tissues to investigate the mechanisms underlying cystic fibrosis, bronchiectasis and primary ciliary dyskinesia. These models allow functional assessment of epithelial biology and provide powerful platforms for studying disease pathways and therapeutic response.

My group integrates stem cell biology, genome engineering, advanced imaging and multi-omics approaches to develop precision medicine platforms capable of predicting individual treatment responses. These systems are used to evaluate emerging therapeutics, identify biomarkers of disease progression and support personalised treatment strategies for patients with chronic respiratory disease.

The laboratory maintains one of the largest collections of patient-derived airway organoid models in Australia, representing a wide spectrum of cystic fibrosis mutations and airway disease phenotypes. This biobank enables translational studies that link patient biology with therapeutic response and supports collaborative research with clinicians and international partners.

In parallel, my research aims to translate stem cell technologies into regenerative therapies for airway disease. My group is developing epithelial transplantation strategies and biomaterial-supported epithelial repair approaches designed to restore airway function in patients with severe respiratory disease.

Beyond laboratory research, I contribute to national capability in human-relevant biomedical research systems. I hold leadership roles in initiatives including the Non-Animal Technologies Network (NAT-Net) and the NSW Organoid Innovation Centre, which aim to accelerate development and adoption of organoid technologies and other human-based experimental models across Australia.

Through these activities, my research advances organoid-based disease modelling, regenerative medicine and precision therapeutic strategies for respiratory disease.