Dr Shafagh Waters
Senior Lecturer

Dr Shafagh Waters

PhD, Australian National University

MSc (Distinction), University of Otago, New Zealand 

BSc, The University of Auckland, New Zealand

 

Medicine & Health
School of Medical Sciences

Dr Shafagh Waters (BSc, MSc (Disc.), PhD) is a Scientia senior lecturer at UNSW and an honorary senior scientist at Sydney Children’s Hospital. A productive PhD (2012; ANU) and postdoctoral fellowships (2013-2016; UNSW) helped her secure international training fellowships in gene therapy and organoid medicine, establishing her independent lab in 2016. Dr Waters lead an NHMRC funded research program on adult-stem-cell biology for cystic fibrosis (CF) that is supported by 32 grants; 21 as CIA including international and national industry partnerships. Dr Waters has developed an Australian national biobank of stem-cell-derived airway and gut organoids, and has built a platform for high-throughput therapy-testing on patients organoids. She combines her unique strengths in organoid disease modelling, multi-omic molecular profiling and computational research with clinical data to improve individualised outcomes for patients with CF. She is regularly invited to media interviews and present at community, and as a keynote speaker at national and international meetings, on two occasions, and was the recipient of the best ECR research award at the 2019-Australian Academy of Science, Precision Medicine Conference. In 2020, the latter (co-culture airway organoid with pathogens) was pivoted to COVID-19 to delineate the innate immune response to SARS-CoV2 infection.

 

Phone
+61 (2)93856961
Location
The School of Medical Sciences is located in the Wallace Wurth Building (upper campus of UNSW) which is accessible via Gate 9, High Street, Randwick.
  • Book Chapters | 2018
    McIntyre K; Waters S; Waters P, 2018, 'Sex Chromosomes', in Skinner MK (ed.), Encyclopedia of Reproduction, edn. 2, Academic Press, pp. 238 - 244, http://dx.doi.org/10.1016/B978-0-12-801238-3.64459-8
    Book Chapters | 2010
    Al Nadaf S; Waters PD; Deakin JE; Graves JAM, 2010, 'Marsupial genetics reveals insights into evolution of mammalian X chromosome inactivation', in Marsupial Genetics and Genomics, pp. 259 - 280, http://dx.doi.org/10.1007/978-90-481-9023-2_13
  • Journal articles | 2022
    Astore MA; Chen P-C; Waters S; Kuyucak S, 2022, 'Computer modelling the root cause of cystic fibrosis', Biophysical Journal, vol. 121, pp. 506a - 506a, http://dx.doi.org/10.1016/j.bpj.2021.11.268
    Journal articles | 2022
    Tran BM; Grimley SL; McAuley JL; Hachani A; Earnest L; Wong SL; Caly L; Druce J; Purcell DFJ; Jackson DC; Catton M; Nowell CJ; Leonie L; Deliyannis G; Waters SA; Torresi J; Vincan E, 2022, 'Air-Liquid-Interface Differentiated Human Nose Epithelium: A Robust Primary Tissue Culture Model of SARS-CoV-2 Infection', International Journal of Molecular Sciences, vol. 23, pp. 835 - 835, http://dx.doi.org/10.3390/ijms23020835
    Journal articles | 2022
    Wong SL; Awatade NT; Astore MA; Allan KM; Carnell MJ; Slapetova I; Chen P-C; Setiadi J; Pandzic E; Fawcett LK; Widger JR; Whan RM; Griffith R; Ooi CY; Kuyucak S; Jaffe A; Waters SA, 2022, 'Molecular Dynamics and Theratyping in Airway and Gut Organoids Reveal R352Q-CFTR Conductance Defect.', Am J Respir Cell Mol Biol, http://dx.doi.org/10.1165/rcmb.2021-0337OC
    Journal articles | 2022
    Wong SL; Awatade NT; Astore MA; Allan KM; Carnell MJ; Slapetova I; Chen PC; Capraro A; Fawcett LK; Whan RM; Griffith R; Ooi CY; Kuyucak S; Jaffe A; Waters SA, 2022, 'Molecular dynamics and functional characterization of I37R-CFTR lasso mutation provide insights into channel gating activity', iScience, vol. 25, pp. 103710 - 103710, http://dx.doi.org/10.1016/j.isci.2021.103710
    Journal articles | 2021
    Allan KM; Wong SL; Fawcett LK; Capraro A; Jaffe A; Herbert C; Pandzic E; Waters SA, 2021, 'Collection, expansion, and differentiation of primary human nasal epithelial cell models for quantification of cilia beat frequency', Journal of Visualized Experiments, http://dx.doi.org/10.3791/63090
    Journal articles | 2021
    Allen K; Jaffe A; Waters S, 2021, 'Treatment of Cystic Fibrosis: From Gene- to Cell-Based Therapies', Frontiers in Pharmacology, http://dx.doi.org/10.3389/fphar.2021.639475
    Journal articles | 2021
    Awatade N; Wong S; Capraro A; Pandzic E; Slapetova I; Zhong L; Fawcett L; Whan R; Jaffe A; Waters S, 2021, 'Significant functional differences in differentiated Conditionally Reprogrammed (CRC)- and Feeder-free Dual SMAD inhibited-expanded human nasal epithelial cells', Journal of Cystic Fibrosis, http://dx.doi.org/10.1016/j.jcf.2020.12.019
    Journal articles | 2021
    Azad AKM; Fatima S; Capraro A; Waters SA; Vafaee F, 2021, 'Integrative resource for network-based investigation of COVID-19 combinatorial drug repositioning and mechanism of action', Patterns, pp. 100325, http://dx.doi.org/10.1016/j.patter.2021.100325
    Journal articles | 2021
    Capraro A; Wong S; Adhikari A; Allan K; Patel H; Zhong L; Raftery M; Jaffe A; Yeang M; Aggarwal A; Wu L; Pandzic E; Whan R; Turville S; Vittorio O; Bull R; Kaakoush N; Rawlinson W; Tedla N; Vafaee F; Waters S, 2021, 'Ageing impairs the airway epithelium defence response to SARS-CoV-2', , http://dx.doi.org/10.1101/2021.04.05.437453
    Journal articles | 2021
    Deshpande NP; Riordan SM; Gorman CJ; Nielsen S; Russell TL; Correa-Ospina C; Fernando BSM; Waters SA; Castaño-Rodríguez N; Man SM; Tedla N; Wilkins MR; Kaakoush NO, 2021, 'Multi-omics of the esophageal microenvironment identifies signatures associated with progression of Barrett’s esophagus', Genome Medicine, vol. 13, pp. 133, http://dx.doi.org/10.1186/s13073-021-00951-6
    Journal articles | 2021
    Fawcett LK; Wakefield CE; Sivam S; Middleton PG; Wark P; Widger J; Jaffe A; Waters SA, 2021, 'Avatar acceptability: views from the Australian Cystic Fibrosis community on the use of personalised organoid technology to guide treatment decisions', ERJ OPEN RESEARCH, vol. 7, http://dx.doi.org/10.1183/23120541.00448-2020
    Journal articles | 2021
    Prentice BJ; Jaffe A; Hameed S; Verge CF; Waters S; Widger J, 2021, 'Cystic fibrosis-related diabetes and lung disease: An update', European Respiratory Review, vol. 30, pp. 200293 - 200293, http://dx.doi.org/10.1183/16000617.0293-2020
    Journal articles | 2021
    Villamizar O; Waters SA; Scott T; Grepo N; Jaffe A; Morris KV, 2021, 'Mesenchymal Stem Cell exosome delivered Zinc Finger Protein activation of cystic fibrosis transmembrane conductance regulator', Journal of Extracellular Vesicles, vol. 10, http://dx.doi.org/10.1002/jev2.12053
    Journal articles | 2020
    Awatade N; Wong S; Pandzic E; Slapetova I; Capraro A; Zhong L; Turgutoglu N; Fawcett L; Whan R; Jaffe A; Waters S, 2020, 'Significant functional differences despite morphological and molecular similarity in fully differentiated matched Conditionally Reprogrammed (CRC) and Feeder free dual SMAD inhibited expanded human nasal epithelial cells', , http://dx.doi.org/10.1101/2020.05.29.120006
    Journal articles | 2020
    Capraro A; O‘Meally D; Waters SA; Patel HR; Georges A; Waters PD, 2020, 'MicroRNA dynamics during hibernation of the Australian central bearded dragon (Pogona vitticeps)', Scientific Reports, vol. 10, http://dx.doi.org/10.1038/s41598-020-73706-9
    Journal articles | 2020
    Capraro A; Whan R; Thomas S; Jaffe A; Bridge W; Waters S, 2020, 'Novel Antioxidant Therapy with the Immediate Precursor to Glutathione, -Glutamylcysteine (GGC), Ameliorates LPS-Induced Cellular Stress in In Vitro 3D-Differentiated Airway Model from Primary Cystic Fibrosis Human Bronchial Cells', Antioxidants, http://dx.doi.org/10.3390/antiox9121204
    Journal articles | 2020
    Coffey MJ; Mckay IR; Doumit M; Chuang S; Adams S; Stelzer-Braid S; Waters SA; Kasparian NA; Thomas T; Jaffe A; Katz T; Ooi CY, 2020, 'Evaluating the Alimentary and Respiratory Tracts in Health and disease (EARTH) research programme: a protocol for prospective, longitudinal, controlled, observational studies in children with chronic disease at an Australian tertiary paediatric hospital', BMJ Open, vol. 10, pp. e033916, http://dx.doi.org/10.1136/bmjopen-2019-033916
    Journal articles | 2020
    Hewson C; Capraro A; Wong S; Pandzic E; Fernando BSM; Awatade N; Zhong L; Hart-Smith G; Whan R; Thomas S; Jaffe A; Bridge W; Waters S, 2020, 'Novel antioxidant therapy with the immediate precursor to glutathione, γ-glutamylcysteine (GGC), ameliorates LPS-induced cellular stress in an in vitro cystic fibrosis model', , http://dx.doi.org/10.1101/2020.05.27.119990
    Journal articles | 2019
    Coffey MJ; Zhong L; Jaffe A; Ooi CY; Waters S, 2019, 'Tu1872 – The Human Intestinal Proteome in Children with Cystic Fibrosis', Gastroenterology, vol. 156, pp. S - 1153, http://dx.doi.org/10.1016/s0016-5085(19)39855-5
    Journal articles | 2019
    Prentice BJ; Ooi CY; Strachan RE; Hameed S; Ebrahimkhani S; Waters SA; Verge CF; Widger J, 2019, 'Early glucose abnormalities are associated with pulmonary inflammation in young children with cystic fibrosis', Journal of Cystic Fibrosis, vol. 18, pp. 869 - 873, http://dx.doi.org/10.1016/j.jcf.2019.03.010
    Journal articles | 2019
    Sprague D; Waters SA; Kirk JM; Wang JR; Samollow PB; Waters PD; Calabrese JM, 2019, 'Nonlinear sequence similarity between the Xist and Rsx long noncoding RNAs suggests shared functions of tandem repeat domains', RNA, vol. 25, pp. 1004 - 1019, http://dx.doi.org/10.1261/rna.069815.118
    Journal articles | 2019
    Villamizar O; Waters SA; Scott T; Saayman S; Grepo N; Urak R; Davis A; Jaffe A; Morris KV, 2019, 'Targeted Activation of Cystic Fibrosis Transmembrane Conductance Regulator', Molecular Therapy, vol. 27, pp. 1737 - 1748, http://dx.doi.org/10.1016/j.ymthe.2019.07.002
    Journal articles | 2019
    Waters S; Waters P; Capraro A, 2019, 'Waking the sleeping dragon: gene expression profiling reveals adaptive strategies of the hibernating reptile Pogona vitticeps', BMC Genomics, http://dx.doi.org/10.1186/s12864-019-5750-x
    Journal articles | 2018
    Awatade N; Wong S; Jaffe A; Waters S, 2018, 'Human Primary Epithelial Cell Models: Promising Tools in the Era of Cystic Fibrosis Personalized Medicine', Frontiers in Pharmacology, vol. 9, pp. 1429, http://dx.doi.org/10.3389/fphar.2018.01429
    Journal articles | 2018
    Johnson RN; O’Meally D; Chen Z; Etherington GJ; Ho SYW; Nash WJ; Grueber CE; Cheng Y; Whittington CM; Dennison S; Peel E; Haerty W; O’Neill RJ; Colgan D; Russell TL; Alquezar-Planas DE; Attenbrow V; Bragg JG; Brandies PA; Chong AYY; Deakin JE; Di Palma F; Duda Z; Eldridge MDB; Ewart KM; Hogg CJ; Frankham GJ; Georges A; Gillett AK; Govendir M; Greenwood AD; Hayakawa T; Helgen KM; Hobbs M; Holleley CE; Heider TN; Jones EA; King A; Madden D; Graves JAM; Morris KM; Neaves LE; Patel HR; Polkinghorne A; Renfree MB; Robin C; Salinas R; Tsangaras K; Waters PD; Waters SA; Wright B; Wilkins MR; Timms P; Belov K, 2018, 'Adaptation and conservation insights from the koala genome', Nature Genetics, vol. 50, pp. 1102 - 1111, http://dx.doi.org/10.1038/s41588-018-0153-5
    Journal articles | 2018
    Waters SA; Capraro A; McIntyre KL; Graves JAM; Waters PD, 2018, 'The methylome of vertebrate sex chromosomes', Genes, vol. 9, http://dx.doi.org/10.3390/genes9050230
    Journal articles | 2018
    Waters SA; Livernois AM; Patel H; O’Meally D; Craig JM; Marshall Graves JA; Suter CM; Waters PD, 2018, 'Landscape of DNA methylation on the marsupial x', Molecular Biology and Evolution, vol. 35, pp. 431 - 439, http://dx.doi.org/10.1093/molbev/msx297
    Journal articles | 2017
    Waters SA; McAteer SP; Kudla G; Pang I; Deshpande NP; Amos TG; Leong KW; Wilkins MR; Strugnell R; Gally DL; Tollervey D; Tree JJ, 2017, 'Small RNA interactome of pathogenic E. coli revealed through crosslinking of RNase E', EMBO Journal, vol. 36, pp. 374 - 387, http://dx.doi.org/10.15252/embj.201694639
    Journal articles | 2016
    Alinejad-Rokny H; Anwar F; Waters SA; Davenport MP; Ebrahimi D, 2016, 'Source of CpG depletion in the HIV-1 genome', Molecular Biology and Evolution, vol. 33, pp. 3205 - 3212, http://dx.doi.org/10.1093/molbev/msw205
    Journal articles | 2015
    Waters SA; Waters PD, 2015, 'Imprinted X chromosome inactivation: evolution of mechanisms in distantly related mammals', AIMS GENETICS, vol. 2, pp. 110 - 126, http://dx.doi.org/10.3934/genet.2015.2.110
    Journal articles | 2014
    Rodríguez-Delgado CL; Waters SA; Waters DP, 2014, 'Paternal X inactivation does not correlate with X chromosome evolutionary strata in marsupials', BMC Evolutionary Biology, vol. 14, http://dx.doi.org/10.1186/s12862-014-0267-z
    Journal articles | 2013
    Livernois AM; Waters SA; Deakin JE; Marshall Graves JA; Waters PD, 2013, 'Independent Evolution of Transcriptional Inactivation on Sex Chromosomes in Birds and Mammals', PLoS Genetics, vol. 9, http://dx.doi.org/10.1371/journal.pgen.1003635
    Journal articles | 2011
    Al Nadaf S; Deakin JE; Gilbert C; Robinson TJ; Graves JA; Waters PD, 2011, 'A cross-species comparison of escape from X inactivation in Eutheria: implications for evolution of X chromosome inactivation.', Chromosoma, vol. 121, pp. 71 - 78, http://dx.doi.org/10.1007/s00412-011-0343-8
    Journal articles | 2011
    Renfree MB; Papenfuss AT; Deakin JE; Lindsay J; Heider T; Belov K; Rens W; Waters PD; Pharo EA; Shaw G; Wong ESW; Lefèvre CM; Nicholas KR; Kuroki Y; Wakefield MJ; Zenger KR; Wang C; Ferguson-Smith M; Nicholas FW; Hickford D; Yu H; Short KR; Siddle HV; Frankenberg SR; Chew KY; Menzies BR; Stringer JM; Suzuki S; Hore TA; Delbridge ML; Mohammadi A; Schneider NY; Hu Y; O'Hara W; Al Nadaf S; Wu C; Feng ZP; Cocks BG; Wang J; Flicek P; Searle SMJ; Fairley S; Beal K; Herrero J; Carone DM; Suzuki Y; Sugano S; Toyoda A; Sakaki Y; Kondo S; Nishida Y; Tatsumoto S; Mandiou I; Hsu A; McColl KA; Lansdell B; Weinstock G; Kuczek E; McGrath A; Wilson P; Men A; Hazar-Rethinam M; Hall A; Davis J; Wood D; Williams S; Sundaravadanam Y; Muzny DM; Jhangiani SN; Lewis LR; Morgan MB; Okwuonu GO; Ruiz SJ; Santibanez J; Nazareth L; Cree A; Fowler G; Kovar CL; Dinh HH; Joshi V; Jing C; Lara F; Thornton R; Chen L; Deng J; Liu Y; Shen JY; Song XZ; Edson J; Troon C; Thomas D; Stephens A; Yapa L; Levchenko T; Gibbs RA; Cooper DW; Speed TP; Fujiyama A; M Graves JA; O'Neill RJ, 2011, 'Genome sequence of an Australian kangaroo, Macropus eugenii, provides insight into the evolution of mammalian reproduction and development', Genome Biology, vol. 12, http://dx.doi.org/10.1186/gb-2011-12-8-r81
    Journal articles | 2011
    Royds JA; Al Nadaf S; Wiles AK; Chen YJ; Ahn A; Shaw A; Bowie S; Lam F; Baguley BC; Braithwaite AW; MacFarlane MR; Hung NA; Slatter TL, 2011, 'The cdkn2a g500 allele is more frequent in gbm patients with no defined telomere maintenance mechanism tumors and is associated with poorer survival', PLoS ONE, vol. 6, http://dx.doi.org/10.1371/journal.pone.0026737
    Journal articles | 2010
    Al Nadaf S; Waters PD; Koina E; Deakin JE; Jordan KS; Graves JAM, 2010, 'Activity map of the tammar X chromosome shows that marsupial X inactivation is incomplete and escape is stochastic', Genome Biology, vol. 11, http://dx.doi.org/10.1186/gb-2010-11-12-r122
  • Conference Abstracts | 2021
    Waters S, 2021, 'Molecular Dynamics to Explain the Pathogenesis of Gating Class Cystic Fibrosis Mutations', in Molecular Dynamics to Explain the Pathogenesis of Gating Class Cystic Fibrosis Mutations, Boston MA (virtual), presented at Biophysical Society Meeting 2021, Boston MA (virtual), https://www.cell.com/biophysj/pdf/S0006-3495(20)32520-0.pdf
    Conference Papers | 2020
    Allan K; Awatade N; Wong S; Jaffe A; Waters S, 2020, 'COMBINATION THERAPY ORKAMBI® (VX‐770/VX‐809) IMPROVES FUNCTION FOR A RARE CFTR MUTATION R117H IN PATIENT‐DERIVED AIRWAY CELL MODELS', in Respirology, Wiley, Melbourne - cancelled due to COVID., presented at TSANZ20_The Thoracic Society of Australia and New Zealand (ANZSRS/TSANZ) Annual Scientific Meeting for Leaders in Lung Health, Melbourne - cancelled due to COVID., http://dx.doi.org/10.1111/resp.13777
    Conference Abstracts | 2020
    Allan K; Awatade N; Wong S; Turgutoglu N; Jaffe A; Waters S, 2020, 'COMBINATION THERAPY ORKAMBI (R) (VX-770/VX-809) IMPROVES FUNCTION FOR A RARE CFTR MUTATION R117H IN PATIENT-DERIVED AIRWAY CELL MODELS', in RESPIROLOGY, WILEY, Vol. 25, pp. 36 - 36, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000538684200067&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2020
    Awatade NIO; Wong S; Jaffe A; Ooi KC; Waters S, 2020, 'INTESTINAL CURRENT MEASUREMENT AS DIAGNOSTIC AND SURROGATE MARKER OF CFTR FUNCTION IN CF', in Respirology, Wiley, Melbourne, Australia_Cancelled due to COVID-19, presented at INTESTINAL CURRENT MEASUREMENT AS DIAGNOSTIC AND SURROGATE MARKER OF CFTR FUNCTION IN CF, Melbourne, Australia_Cancelled due to COVID-19, http://dx.doi.org/10.1111/resp.13777
    Conference Abstracts | 2020
    Fawcett L; Wakefield C; Widger J; Jaffe A; Waters S, 2020, 'ACCEPTABILITY OF USING PERSONALISED MINI‐ORGAN‐AVATARS TO ACCELERATE DRUG DISCOVERY AND PREDICT DRUG RESPONSE IN CYSTIC FIBROSIS PATIENTS', in TSANZSRS 2020 The Australia & New Zealand Society of Respiratory Science and The Thoracic Society of Australia and New Zealand (ANZSRS/TSANZ) Annual Scientific Meeting for Leaders in Lung Health & Respiratory Science, Melbourne - cancelled due to COVID, presented at TSANZSRS 2020, Melbourne - cancelled due to COVID, http://dx.doi.org/10.1111/resp.13778
    Conference Abstracts | 2020
    Hewson C; Wong S; Awatade N; Bridge W; Jaffe A; Waters S, 2020, 'A NOVEL COMPOUND FOR CYSTIC FIBROSIS THERAPY, TARGETING THE PROTEOSTASIS NETWORK', in Respirology, Wiley, Melbourne, Australia_Cancelled due to COVID-19, presented at TSANZ20_The Thoracic Society of Australia and New Zealand (ANZSRS/TSANZ) Annual Scientific Meeting for Leaders in Lung Health, Melbourne, Australia_Cancelled due to COVID-19, http://dx.doi.org/10.1111/resp.13777
    Conference Abstracts | 2020
    Wong S; Awatade N; Fawcett L; Ooi KC; Jaffe A; Waters S, 2020, 'FUNCTIONAL AND PHARMACOLOGICAL CHARACTERIZATION OF RARE R352Q CFTR MUTATION IN PATIENT‐DERIVED DIFFERENTIATED NASAL EPITHELIAL CELLS AND INTESTINAL ORGANOIDS', in Respirology, Wiley, Melbourne, Australia_Cancelled due to COVID-19, presented at TSANZ20_The Thoracic Society of Australia and New Zealand (ANZSRS/TSANZ) Annual Scientific Meeting for Leaders in Lung Health, Melbourne, Australia_Cancelled due to COVID-19, http://dx.doi.org/10.1111/resp.13777
    Conference Abstracts | 2020
    Wong S; Awatade N; Jaffe A; Waters S, 2020, 'ESTABLISHING PATIENT‐DERIVED NASAL SPHEROIDS AS A NON‐INVASIVE PERSONALISED MODEL FOR ASSESSING CFTR MODULATORS EFFECTIVENESS IN PATIENTS WITH CF', in Respirology, Wiley, Melbourne, Australia_Cancelled due to COVID-19, presented at TSANZ20_The Thoracic Society of Australia and New Zealand (ANZSRS/TSANZ) Annual Scientific Meeting for Leaders in Lung Health, Melbourne, Australia_Cancelled due to COVID-19, http://dx.doi.org/10.1111/resp.13778
    Conference Abstracts | 2019
    Coffey MJ; Zhong L; Jaffe A; Ooi CY; Waters S, 2019, 'THE INTESTINAL PROTEOME IN CHILDREN WITH CYSTIC FIBROSIS DIFFERS FROM HEALTHY CONTROLS', in PEDIATRIC PULMONOLOGY, WILEY, Vol. 54, pp. S265 - S265, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000484544000385&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2019
    Fawcett L; Turgutoglu N; Awatade N; Wong S; Widger J; Jaffe A; Waters S, 2019, 'COMPARISON OF TWO DIFFERENT CYTOLOGY BRUSHES FOR COLLECTION OF NASAL MUCOSAL CELLS', in RESPIROLOGY, WILEY, Vol. 24, pp. 115 - 115, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000461458900217&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2019
    Hng Y; Waters S; Chen Y; Thomas P; Herbert C, 2019, 'EXOSOME-RELATED MEDIATORS IN SERUM AND EXHALED BREATH CONDENSATE IN SARCOIDOSIS', in RESPIROLOGY, WILEY, Vol. 24, pp. 116 - 116, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000461458900219&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2019
    McKay IR; Coffey MJ; Doumit M; Bramley L; Sharp M; Kasparian N; Chuang S; Stelzer-Braid S; Waters S; Thomas T; Jaffe A; Katz TE; Ooi CY, 2019, 'A GUT FEELING: CORRELATING DIETARY INTAKE WITH THE GASTROINTESTINAL AND RESPIRATORY MICROBIOTA IN CYSTIC FIBROSIS', in PEDIATRIC PULMONOLOGY, WILEY, Vol. 54, pp. S261 - S262, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000484544000375&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2019
    Waters S; Awatade N; Wong S; Hewson C; Fawcett L; Ooi K; Widger J; Jaffe A, 2019, 'TRANSFORMATIVE THERAPIES FOR ULTRA-RARE CFTR MUTATIONS IN PRIMARY PRE-CLINICAL MODELS', in RESPIROLOGY, WILEY, pp. 141 - 141, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000461458900268&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2019
    Waters S; Villamizar O; Jaffe A; Morris K, 2019, 'Targeted Activation of Cystic Fibrosis Transmembrane Conductance Regulator', in Targeted Activation of Cystic Fibrosis Transmembrane Conductance Regulator, presented at 33rd Annual North American Cystic Fibrosis Conference, http://mc.manuscriptcentral.com/ppul
    Conference Abstracts | 2018
    Prentice B; Hameed S; Verge C; Ooi C; Strachan R; Waters S; Widger J, 2018, 'HYPERGLYCAEMIA IN YOUNG CHILDREN WITH CYSTIC FIBROSIS CORRELATES WITH INFECTION AND NEUTROPHIL BURDEN ON BRONCHOALVEOLAR LAVAGE', in RESPIROLOGY, WILEY, Vol. 23, pp. 34 - 34, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000427591800055&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Preprints |
    Azad AKM; Fatima S; Capraro A; Waters SA; Vafaee F, An Integrative Resource for Network-Based Investigation of COVID-19 Combinatorial Drug Repositioning and Mechanism of Action, http://dx.doi.org/10.26434/chemrxiv-2021-tk6rt-v2
    Preprints |
    Azad AKM; Fatima S; Capraro A; Waters SA; Vafaee F, An Integrative Resource for Network-Based Investigation of COVID-19 Combinatorial Drug Repositioning and Mechanism of Action, http://dx.doi.org/10.33774/chemrxiv-2021-tk6rt-v2
    Preprints |
    Sprague D; Waters SA; Kirk JM; Wang JR; Samollow PB; Waters PD; Calabrese JM, Non-linear sequence similarity between the Xist and Rsx long noncoding RNAs suggests shared functions of tandem repeat domains, http://dx.doi.org/10.1101/630475
    Preprints |
    Wong SL; Awatade NT; Astore MA; Allan KM; Carnell MJ; Slapetova I; Chen P-C; Capraro A; Fawcett LK; Whan RM; Griffith R; Ooi CY; Kuyucak S; Jaffe A; Waters SA, In silico and functional characterisation of an ultra-rare CFTR mutation identifies novel lasso motif interactions regulating channel gating, http://dx.doi.org/10.1101/2021.12.12.472297
    Preprints |
    Wong SL; Awatade NT; Astore MA; Allan KM; Carnell MJ; Slapetova I; Chen P-C; Setiadi J; Pandzic E; Fawcett LK; Widger JR; Whan RM; Griffith R; Ooi CY; Kuyucak S; Jaffe A; Waters SA, Molecular dynamics and theratyping in airway and gut organoids reveal R352Q-CFTR conductance defect, http://dx.doi.org/10.1101/2021.08.11.456003

Scheme: Ideas Grants
Funding agency: National Health & Medical Research Council 
Grant name: Towards Personalised Cystic Fibrosis Medicine: Functional characterisation and targeted therapies for rare CF Transmembrane Regulator (CFTR) mutations using patient-derived organoids
Role: CIA, UNSW Grant number: RG191611 Start date: 1 January 2020

Scheme: 2019 Gene Therapy Innovation Grant
Funding agency: Cystic Fibrosis Community Care 
Grant name: Nanoparticle nanoparticle gene addition therapy in primary differentiated CF airway cell models.
Role: Sole CI, UNSW Grant number: RG194254 Start date: 1 January 2020

Scheme: Orphan Disease Center Million Dollar Bike Ride Grant Program
Funding agency: Penn Medicine Orphan Disease Centre | University of Adelaide  
Grant name: Airway Cell Therapy for Cystic Fibrosis Nonsense Mutations
Role: co-CI, UNSW Grant number: RG192792 Start date: 1 June 2019

Scheme: DAVID MILLAR GILES INNOVATION GRANT
Funding agency: CYSTIC FIBROSIS AUSTRALIA
Grant name: an australian alliance of personalised lab grown mini-organs to save the rarest of them all
Role: Sole CI, UNSW Grant number: RG191126 Start date: 1 August 2019
 

Scheme: TSANZ VERTEX PAEDIATRIC CYSTIC FIBROSIS AWARD
Funding agency: THORACIC SOCIETY OF AUSTRALIA AND NEW ZEALAND (TSANZ)
Grant name: a novel compound for cystic fibrosis therapy, targeting proteostasis network.
Role: Sole CI, UNSW Grant number: RG192793 Start date: 17 July 2019

Scheme: NSW HEALTH PAEDIATRIC PRECISION MEDICINE SHARED GRANT
Funding agency: PAEDIATRIO LIMITED
Grant name: ppm 1: centralized capacity to develop functional genomics for paediatric precision medicine
Role: CIB, UNSW Grant number: RG192369, Start date: 1 June 2019

Scheme: REBECCA L. COOPER MEDICAL PROJECT GRANTS
Funding agency: REBECCA L. COOPER MEDICAL RESEARCH FOUNDATION
Grant name: personalised lab grown mini-lungs to predict effect of therapies in patients with cystic fibrosis
Role: Sole CI, UNSW Grant number: RG182229, Start date: 1 January 2019

Scheme: CONTRACT RESEARCH
Funding agency: PAEDIATRIO LIMITED
Grant name: microscope funding for drug discovery and efficacy testing
Role: CIB, UNSW Grant number: RG182726, Start date: 24 October 2018

Scheme: VERTEX INNOVATION AWARDS
Funding agency: VERTEX PHARMACEUTICALS (CH)
Grant name: exo-cf; exosomal biomarkers for early prediction of cystic fibrosis related diabetes (cfrd)
Role: CIA, UNSW Grant number: RG181847, Start date: 22 March 2019

Scheme: ACFRT INNOVATION GRANT
Funding agency: CYSTIC FIBROSIS RESEARCH LIMITED QLD
Grant name: Rna therapeutics: novel paradigm in mutation independent cf therapy
Role: CIA, UNSW Grant number: RG173352, Start date: 5 March 2018

Scheme: BOOSTING BUSINESS INNOVATION PROGRAM
Funding agency: NSW DEPARTMENT OF INDUSTRY
Grant name: in vitro investigation of the potential efficacy of thiols to treat cystic fibrosis - techvoucher
Role: CIA, UNSW Grant number: RG161881-T Start date: 23 June 2018

Scheme: CONTRACT RESEARCH
Funding agency: BIOSPECIALTIES AUSTRALIA PTY LTD
Grant name: in vitro investigation of the potential efficacy of thiols to treat cystic fibrosis
Role: CIA, UNSW Grant number: RG181150, Start date: 4 June 2018

Awards

Best EMCR Poster Award

Australian Academy of Science | AU-China Precision Medicine Symposium

2019

EMCR Travel Award

Australian Academy of Science | AU-China Precision Medicine Symposium

2019

Travel Award

Australian Academy of Science | Science at the Shine Dome Early-and Mid-Career Researchers Program

2018

Finalist

Annual Quality and Innovation Awards | The Sydney Children’s Hospital Network

2018

Travel Award

SIDRA Functional Genomics Towards Precision Medicine Symposium. Doha Qatar

2017

Travel Award

Vice-Chancellor's HDR | Australian National University (ANU)

2012

Best PhD Candidate Talk Award

Genetics Society of Australasia Conference 2010

2010

Travel Award

University of Otago, New Zealand

2008

Best Poster Presentation Award

Molecular Basis of Cancer and Development Meeting 2007

2007

 

Fellowships

Bridging Fellowship

 UNSW, Australia

2020- 2023

Visiting Scientist Fellowship

City of Hope Medical Centre for Gene Therapy, USA

March-2016

Visiting Researcher ECFS Fellowship

University of Lisbon (ULisboa), Portugal

June-2016

PhD Scholarship

Australian National University (ANU)

2008

PhD Supplementary Scholarship

Australian National University (ANU)

2008

Summer Research Fellowship

Australian National University (ANU) | Graves Lab

2007

Summer Research Fellowship

University of Otago, New Zealand | Markie Lab

2006

 

Memberships

UNSW Australian Centre for NanoMedicine (ACN

2021

Australian Living Organoid Alliance (ALOA)

2020

The Thoracic Society of Australia and New Zealand (TSANZ)

2018

Early- & Mid – Career Research Forum, Australian Academy of Science

2018

Australian Society for Medical Research

2017

Women in Research Network member, UNSW

2017

Genetic Society of AustralAsia (GSA)

2012

My current research has a strong translational focus in three key areas of

(i) stem cell biology involving disease modeling and regenerative medicine

(ii) prognostic and diagnostic exosomal biomarker discovery for CF related diabetes,

(iii) CFTR restoring therapeutics in patient derived organoids using a variety of delivery approaches including viral and nanoformulations.

(iv) host-pathogen interactions for viral and bacterial infections.

Memberships