Associate Professor Shane   Thomas
Associate Professor

Associate Professor Shane Thomas

Medicine & Health
Biomedical Research Institute

Research Interests:
The Redox Cell Signalling Laboratory focuses on two major research areas:

1. Identification of the redox reactions and cell signaling pathways important for endothelial dysfunction during vascular disease


The endothelium is critical for the maintenance of vascular homeostasis. Central to this is endothelium-derived nitric oxide (EDNO), synthesized by the endothelial nitric oxide synthase (eNOS). Vascular diseases including diabetes, atherosclerosis and hypertension are characterized by endothelial dysfunction that is manifested as impaired EDNO bioactivity that contributes to clinical cardiovascular events. Considerable evidence shows that endothelial dysfunction is due to oxidative stress in the blood vessel wall and there is great interest in defining the oxidative processes and cell signalling events involved.

Oxidative stress and endothelial dysfunction
This project aims to define the oxidative reactions promoting endothelial dysfunction during vascular disease. At present we focus on the oxidative enzyme myeloperoxidase (MPO) that during vascular disease accumulates in the sub-endothelium of diseased blood vessels where it is ideally placed to impact on endothelial function. We are currently investigating the oxidative and cell signalling mechanisms by which MPO impacts on EDNO bioactivity and endothelial function in vascular disease and testing novel agents for their ability to selectively remove MPO from the endothelium. These agents may represent potential therapeutics to combat endothelial dysfunction.

Redox control of endothelial cell signalling
Reduction and oxidation (redox) reactions represent important transducers of vascular cell signalling pathways. This project aims to identify the redox responsive cell signalling pathways in endothelial cells stimulated with agonists (e.g., vascular endothelial growth factor, angiotensin II) and to define the nature and intracellular source of the redox-active signalling species.
 

2. Roles and Regulation of Indoleamine 2, 3-Dioxygenase

Indoleamine 2, 3-dioxygenase (IDO) is an intracellular heme enzyme that catalyses the catabolism of L-tryptophan (L-Trp). IDO represents a central immune regulatory enzyme. Thus, expression of IDO in professional antigen presenting cells or tumor cells and resultant depletion of L-Trp, the least abundant essential amino acid, inhibits T lymphocyte activation to promote immune suppression and tolerance during inflammation, transplantation, auto-immunity and cancer.

IDO and Vascular Disease
Atherosclerosis is a chronic inflammatory disease of the artery in which T lymphocyte-mediated immune reactions play an important role. We have detected increased IDO expression in atherosclerotic lesions and currently testing if IDO activity expressed in immune cells inhibits atherosclerosis by limiting T cell activation and vascular inflammation.

Regulation of IDO activity
In light of the important immune regulatory roles of IDO it is important to understand how the enzyme is controlled. Our previous studies were the first to describe post-translational regulation of IDO and this project aims to characterize the post-translational modifications involved and the extent to which they govern the immune regulatory actions of antigen presenting cells and tumour cells. Identification of how IDO is regulated may facilitate the development of novel drug strategies to modulate IDO activity in vivo.


Broad Research Areas:

Cardiology and Vascular Disease, Immunology, Cell Biology and Gene Regulation, Biochemistry, Cancer

Society Memberships & Professional Activities:
Australasian Society for Free Radical Research, Australian Vascular Biology Society, Australian Society for Medical Research

Specific Research Keywords:
Vascular Biology, Cell Biology and Immunology, Cancer, Inflammation, Nitric oxide

Phone
+61 2 9385 2582

Publications

  • Book Chapters | 2000
    Associate Professor Shane Thomas
    Thomas SR; Stocker R, 2000, 'Mechanisms of antioxidant action of ubiquinol-10 for low-density lipoprotein', in Coenzyme Q: Molecular Mechanisms in Health and Disease, pp. 131 - 150
    Book Chapters | 2000
    Associate Professor Shane Thomas
    Thomas SR; Stocker R, 2000, 'Mechanisms of antioxidant action of ubiquinol-10 for low-density lipoprotein', in Coenzyme Q: Molecular Mechanisms in Health and Disease, pp. 131 - 150
  • Journal articles | 2021
    Associate Professor Shane Thomas
    Maiocchi SL; Ku J; Thai T; Chan E; Rees MD; Thomas SR, 2021, 'Myeloperoxidase: A versatile mediator of endothelial dysfunction and therapeutic target during cardiovascular disease', Pharmacology and Therapeutics, vol. 221, pp. 107711, http://dx.doi.org/10.1016/j.pharmthera.2020.107711
    Journal articles | 2021
    Associate Professor Shane Thomas
    Thai T; Zhong F; Dang L; Chan E; Ku J; Malle E; Geczy CL; Keaney JF; Thomas SR, 2021, 'Endothelial-transcytosed myeloperoxidase activates endothelial nitric oxide synthase via a phospholipase C-dependent calcium signaling pathway', Free Radical Biology and Medicine, vol. 166, pp. 255 - 264, http://dx.doi.org/10.1016/j.freeradbiomed.2020.12.448
    Journal articles | 2020
    Associate Professor Shane Thomas
    El Kazzi M; Rayner BS; Chami B; Dennis JM; Thomas SR; Witting PK, 2020, 'Neutrophil-mediated cardiac damage after acute myocardial infarction: Significance of defining a new target cell type for developing cardioprotective drugs', Antioxidants and Redox Signaling, vol. 33, pp. 689 - 712, http://dx.doi.org/10.1089/ars.2019.7928
    Journal articles | 2020
    Associate Professor Shane Thomas
    Capraro A; Whan R; Thomas S; Jaffe A; Bridge W; Waters S, 2020, 'Novel Antioxidant Therapy with the Immediate Precursor to Glutathione, -Glutamylcysteine (GGC), Ameliorates LPS-Induced Cellular Stress in In Vitro 3D-Differentiated Airway Model from Primary Cystic Fibrosis Human Bronchial Cells', Antioxidants, http://dx.doi.org/10.3390/antiox9121204
    Journal articles | 2019
    Associate Professor Shane Thomas
    Lim YJ; Foo TC; Yeung AWS; Tu X; Ma Y; Hawkins CL; Witting PK; Jameson GNL; Terentis AC; Thomas SR, 2019, 'Human Indoleamine 2,3-Dioxygenase 1 Is an Efficient Mammalian Nitrite Reductase', Biochemistry, vol. 58, pp. 974 - 986, http://dx.doi.org/10.1021/acs.biochem.8b01231
    Journal articles | 2019
    Associate Professor Shane Thomas
    Rodrigo C; Tedla N; Thomas S; Polly P; Herbert C; Velan G; Saunders DN, 2019, 'Using Narratives to Teach Students Enrolled in Science and Medical Science Bachelor’s Degree Programs', Medical Science Educator, vol. 29, pp. 357 - 361, http://dx.doi.org/10.1007/s40670-019-00698-1
    Journal articles | 2018
    Associate Professor Shane Thomas
    Manuneedhi Cholan P; Cartland SP; Dang L; Rayner BS; Patel S; Thomas SR; Kavurma MM, 2018, 'TRAIL protects against endothelial dysfunction in vivo and inhibits angiotensin-II-induced oxidative stress in vascular endothelial cells in vitro', Free Radical Biology and Medicine, vol. 126, pp. 341 - 349, http://dx.doi.org/10.1016/j.freeradbiomed.2018.08.031
    Journal articles | 2018
    Associate Professor Shane Thomas
    Ramarathinam SH; Gras S; Alcantara S; Yeung AWS; Mifsud NA; Sonza S; Illing PT; Glaros EN; Center RJ; Thomas SR; Kent SJ; Ternette N; Purcell DFJ; Rossjohn J; Purcell AW, 2018, 'Identification of Native and Posttranslationally Modified HLA-B*57:01-Restricted HIV Envelope Derived Epitopes Using Immunoproteomics', Proteomics, vol. 18, http://dx.doi.org/10.1002/pmic.201700253
    Journal articles | 2018
    Associate Professor Shane Thomas
    Manuneedhi Cholan P; Cartland S; Rayner B; Genner S; Dang L; Thomas S; Kavurma M, 2018, 'Abstract 055: TRAIL Protects Against Endothelial Dysfunction in vivo and Inhibits Angiotensin-II Induced Oxidative Stress in Vascular Endothelial Cells in vitro', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 38, http://dx.doi.org/10.1161/atvb.38.suppl_1.055
    Journal articles | 2018
    Associate Professor Shane Thomas
    Manuneedhi Cholan P; Cartland S; Rayner B; Genner S; Dang L; Thomas S; Kavurma M, 2018, 'Abstract 302: TRAIL Protects Against Endothelial Dysfunction in vivo and Inhibits Angiotensin-II Induced Oxidative Stress in Vascular Endothelial Cells in vitro', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 38, http://dx.doi.org/10.1161/atvb.38.suppl_1.302
    Journal articles | 2018
    Associate Professor Shane Thomas
    Liou K; Li J; Guiney L; Thomas S; Glaros E; Ooi S, 2018, 'Coronary Myeloperoxidase Provides Superior Characterisation of Coronary Inflammation in Patients Undergoing Percutaneous Coronary Interventions in the Setting of Non-ST Elevation Acute Coronary Syndrome', Heart, Lung and Circulation, vol. 27, pp. S311 - S311, http://dx.doi.org/10.1016/j.hlc.2018.06.598
    Journal articles | 2017
    Associate Professor Shane Thomas
    Cartland SP; Harith HH; Genner SW; Dang L; Cogger VC; Vellozzi M; Di Bartolo BA; Thomas SR; Adams LA; Kavurma MM, 2017, 'Non-alcoholic fatty liver disease, vascular inflammation and insulin resistance are exacerbated by TRAIL deletion in mice', Scientific Reports, vol. 7, http://dx.doi.org/10.1038/s41598-017-01721-4
    Journal articles | 2017
    Associate Professor Shane Thomas
    Maiocchi SL; Morris JC; Rees MD; Thomas SR, 2017, 'Regulation of the nitric oxide oxidase activity of myeloperoxidase by pharmacological agents', Biochemical Pharmacology, vol. 135, pp. 90 - 115, http://dx.doi.org/10.1016/j.bcp.2017.03.016
    Journal articles | 2016
    Associate Professor Shane Thomas
    Tran J; Magenau A; Rodriguez M; Rentero C; Royo T; Enrich C; Thomas SR; Grewal T; Gaus K, 2016, 'Activation of endothelial nitric oxide (eNOS) occurs through different membrane domains in endothelial cells', PLoS ONE, vol. 11, http://dx.doi.org/10.1371/journal.pone.0151556
    Journal articles | 2016
    Associate Professor Shane Thomas
    Thoms JAI; Knezevic K; Liu JJ; Glaros EN; Thai T; Qiao Q; Campbell H; Packham D; Huang Y; Papathanasiou P; Tunningley R; Whittle B; Yeung AWS; Chandrakanthan V; Hesson L; Chen V; Wong JWH; Purton LE; Ward RL; Thomas SR; Pimanda JE, 2016, 'Arrested hematopoiesis and vascular relaxation defects in mice with a mutation in Dhfr', Molecular and Cellular Biology, vol. 36, pp. 1222 - 1236, http://dx.doi.org/10.1128/MCB.01035-15
    Journal articles | 2016
    Associate Professor Shane Thomas
    Huang Y; Thoms JAI; Tursky ML; Knezevic K; Beck D; Chandrakanthan V; Suryani S; Olivier J; Boulton A; Glaros EN; Thomas SR; Lock RB; MacKenzie KL; Bushweller JH; Wong JWH; Pimanda JE, 2016, 'MAPK/ERK2 phosphorylates ERG at serine 283 in leukemic cells and promotes stem cell signatures and cell proliferation', Leukemia, vol. 30, pp. 1552 - 1561, http://dx.doi.org/10.1038/leu.2016.55
    Journal articles | 2016
    Associate Professor Shane Thomas
    Liou K; Jepson N; Buckley N; Chen V; Thomas S; Russell EA; Ooi SY, 2016, 'Design and Rationale for the Endothelin-1 Receptor Antagonism in the Prevention of Microvascular Injury in Patients with non-ST Elevation Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention (ENDORA-PCI) Trial', Cardiovascular Drugs and Therapy, vol. 30, pp. 169 - 175, http://dx.doi.org/10.1007/s10557-016-6641-x
    Journal articles | 2016
    Associate Professor Shane Thomas
    Thomas SR, 2016, 'Haematopoietic-expressed C/EBPβ: A novel transcriptional regulator of hepatic liver metabolism and macrophage foam cells during atherosclerosis?', Atherosclerosis, vol. 250, pp. 183 - 185, http://dx.doi.org/10.1016/j.atherosclerosis.2016.05.015
    Journal articles | 2016
    Associate Professor Shane Thomas
    Yeung AWS; Lim YJ; Hastad M; Dang L; Örfi L; Szabadkai I; Kéri G; Terentis AC; King NJC; Witting PK; Thomas SR, 2016, 'Redox Control of the Critical Immune Regulatory Enzyme Indoleamine 2,3-Dioxygenase by NADPH Oxidase 2-Derived Reactive Oxygen Species in Human Monocytes', Free Radical Biology and Medicine, vol. 100, pp. S62 - S62, http://dx.doi.org/10.1016/j.freeradbiomed.2016.10.162
    Journal articles | 2015
    Associate Professor Shane Thomas
    Yeung AWS; Terentis AC; King NJC; Thomas SR, 2015, 'Role of indoleamine 2,3-dioxygenase in health and disease', Clinical Science, vol. 129, pp. 601 - 672, http://dx.doi.org/10.1042/CS20140392
    Journal articles | 2015
    Associate Professor Shane Thomas
    Das T; Kutty SK; Tavallaie R; Ibugo AI; Panchompoo J; Sehar S; Aldous L; Yeung AWS; Thomas SR; Kumar N; Gooding JJ; Manefield M, 2015, 'Phenazine virulence factor binding to extracellular DNA is important for Pseudomonas aeruginosa biofilm formation', Scientific Reports, vol. 5, http://dx.doi.org/10.1038/srep08398
    Journal articles | 2015
    Associate Professor Shane Thomas
    Di Bartolo BA; Cartland SP; Prado-Lourenco L; Griffith TS; Gentile C; Ravindran J; Azahri NSM; Thai T; Yeung AWS; Thomas SR; Kavurma MM, 2015, 'Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) promotes angiogenesis and ischemia-induced neovascularization via NADPH oxidase 4 (NOX4) and nitric oxide-dependent mechanisms', Journal of the American Heart Association, vol. 4, http://dx.doi.org/10.1161/JAHA.115.002527
    Journal articles | 2015
    Associate Professor Shane Thomas
    Nasrallah R; Knezevic K; Thai T; Thomas SR; Göttgens B; Lacaud G; Kouskoff V; Pimanda JE, 2015, 'Endoglin potentiates nitric oxide synthesis to enhance definitive hematopoiesis', Biology Open, vol. 4, pp. 819 - 829, http://dx.doi.org/10.1242/bio.011494
    Journal articles | 2015
    Associate Professor Shane Thomas
    Rees MD; Thomas SR, 2015, 'Using cell-substrate impedance and live cell imaging to measure real-time changes in cellular adhesion and de-adhesion induced by matrix modification', Journal of visualized experiments : JoVE, http://dx.doi.org/10.3791/52423
    Journal articles | 2015
    Associate Professor Shane Thomas
    Rees MD; Thomas SR, 2015, 'Using cell-substrate impedance and live cell imaging to measure real-time changes in cellular adhesion and de-adhesion induced by matrix modification', Journal of Visualized Experiments, http://dx.doi.org/10.3791/52423
    Journal articles | 2014
    Associate Professor Shane Thomas
    Rees MD; Maiocchi SL; Kettle AJ; Thomas SR, 2014, 'Mechanism and regulation of peroxidase-catalyzed nitric oxide consumption in physiological fluids: Critical protective actions of ascorbate and thiocyanate', Free Radical Biology and Medicine, vol. 72, pp. 91 - 103, http://dx.doi.org/10.1016/j.freeradbiomed.2014.03.037
    Journal articles | 2014
    Associate Professor Shane Thomas
    Cochran BJ; Bisoendial RJ; Hou L; Glaros E; Rossy J; Thomas SR; Barter PJ; Rye KA, 2014, 'Apolipoprotein a-I increases insulin secretion and production from pancreatic β-cells via a g-protein-camp-PKA-FOXO1-dependent mechanism', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 34, pp. 2261 - 2267, http://dx.doi.org/10.1161/ATVBAHA.114.304131
    Journal articles | 2014
    Associate Professor Shane Thomas
    Stapelberg M; Zobalova R; Nguyen MN; Walker T; Stantic M; Goodwin J; Pasdar EA; Thai T; Prokopova K; Yan B; Hall S; De Pennington N; Thomas SR; Grant G; Stursa J; Bajzikova M; Meedeniya ACB; Truksa J; Ralph SJ; Ansorge O; Dong LF; Neuzil J, 2014, 'Indoleamine-2,3-dioxygenase elevated in tumor-initiating cells is suppressed by mitocans', Free Radical Biology and Medicine, vol. 67, pp. 41 - 50, http://dx.doi.org/10.1016/j.freeradbiomed.2013.10.003
    Journal articles | 2014
    Associate Professor Shane Thomas
    Sherrah AG; Edelman JJB; Thomas SR; Brady PW; Wilson MK; Jeremy RW; Bannon PG; Vallely MP, 2014, 'The freestyle aortic bioprosthesis: A systematic review', Heart Lung and Circulation, vol. 23, pp. 1110 - 1117, http://dx.doi.org/10.1016/j.hlc.2014.04.262
    Journal articles | 2014
    Associate Professor Shane Thomas
    Maiocchi SL; Thomas SR; Rees MD, 2014, 'Regulation of the NO Oxidase Activity of Myeloperoxidase by Pharmacological Agents', FREE RADICAL BIOLOGY AND MEDICINE, vol. 76, pp. S17 - S17, http://dx.doi.org/10.1016/j.freeradbiomed.2014.10.497
    Journal articles | 2013
    Associate Professor Shane Thomas
    Rivera J; Walduck AK; Thomas SR; Glaros EN; Hooker EU; Guida E; Sobey CG; Drummond GR, 2013, 'Accumulation of serum lipids by vascular smooth muscle cells involves a macropinocytosis-like uptake pathway and is associated with the downregulation of the ATP-binding cassette transporter A1', Naunyn-Schmiedeberg's Archives of Pharmacology, vol. 386, pp. 1081 - 1093, http://dx.doi.org/10.1007/s00210-013-0909-5
    Journal articles | 2013
    Associate Professor Shane Thomas
    Freewan M; Rees MD; Sempertegui plaza T; Glaros EN; Lim YJ; Wang X; Yeung AWS; Witting PK; Terentis AC; Thomas SR, 2013, 'Human Indoleamine 2,3-dioxygenase is a catalyst of physiological heme peroxidase reactions: implications for the inhibition of dioxygenase activity by hydrogen peroxide', The Journal of Biological Chemistry, vol. 288, pp. 1548 - 1567, http://dx.doi.org/10.1074/jbc.M112.410993
    Journal articles | 2013
    Associate Professor Shane Thomas
    Sherrah AG; Edelman JJB; Thomas SR; Brady PW; Wilson MK; Jeremy RW; Bannon PG; Vallely MP, 2013, 'The Freestyle Aortic Bioprosthesis: A Systematic Review', Heart Lung and Circulation, http://dx.doi.org/10.1016/j.hlc.2014.04.262
    Journal articles | 2012
    Associate Professor Shane Thomas
    Getts DR; Terry RL; Teague Getts M; Muller M; Rana S; Deffrasnes C; Ashhurst TM; Radford J; Hofer M; Thomas SR; Campbell IL; King NJC, 2012, 'Targeted blockade in lethal West Nile virus encephalitis indicates a crucial role for very late antigen (VLA)-4-dependent recruitment of nitric oxide-producing macrophages', Journal of Neuroinflammation, vol. 9, http://dx.doi.org/10.1186/1742-2094-9-246
    Journal articles | 2012
    Associate Professor Shane Thomas
    Yeung AWC; Wu W; Freewan M; Stocker R; King NJC; Thomas SR, 2012, 'Flavivirus infection induces indoleamine 2,3-dioxygenase in human monocyte-derived macrophages via tumor necrosis factor and NF-êB', Journal of Leukocyte Biology, vol. 91, pp. 657 - 666, http://dx.doi.org/10.1189/jlb.1011532
    Journal articles | 2012
    Associate Professor Shane Thomas
    Li C; Lonn ME; Xu X; Magzhal G; Frazer D; Thomas SR; Halliwell B; Richardson DR; Anderson GJ; Stocker R, 2012, 'Sustained expression of heme oxygenase-1 alters iron homeostasis in nonerythroid cells', Free Radical Biology and Medicine, vol. 53, pp. 366 - 374, http://dx.doi.org/10.1016/j.freeradbiomed.2012.03.007
    Journal articles | 2011
    Associate Professor Shane Thomas
    Herbert AD; Ng H; Jessup W; Kockx M; Cartland SP; Thomas SR; Hogg PJ; Wargon O, 2011, 'Hypoxia regulates the production and activity of glucose transporter-1 and indoleamine 2,3-dioxygenase in monocyte-derived endothelial-like cells: possible relevance to infantile haemangioma pathogenesis', British Journal of Dermatology, vol. 164, pp. 308 - 315, http://dx.doi.org/10.1111/j.1365-2133.2010.10086.x/abstract
    Journal articles | 2011
    Associate Professor Shane Thomas
    Meotti FC; Jameson GNL; Turner R; Harwood D; Stockwell S; Rees MD; Thomas SR; Kettle AJ, 2011, 'Urate as a physiological substrate for myeloperoxidase: Implications for hyperuricemia and inflammation', The Journal of Biological Chemistry, vol. 286, pp. 12901 - 12911, http://dx.doi.org/10.1074/jbc.M110.172460
    Journal articles | 2011
    Associate Professor Shane Thomas
    Munoz-Erazo L; Yeung A; Madigan M; Thomas S; King N, 2011, 'BALANCE OF INDOLEAMINE 2,3 DIOXYGENASE AND INDUCIBLE NITRIC OXIDE SYNTHASE RESPONSES IN WEST NILE VIRUS-INFECTED HUMAN RETINAL PIGMENT EPITHELIUM', CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, vol. 39, pp. 87 - 87, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000296914400169&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 2010
    Associate Professor Shane Thomas
    Wang Y; Liu H; McKenzie GL; Witting PK; Stasch J; Hahn M; Changsirivathanathamrong D; Wu BJ; Ball HJ; Thomas SR; Kapoor V; Celermajer DS; Mellor AL; Keaney Jr JF; Hunt NH; Stocker R, 2010, 'Kynurenine is an endothelium-derived relaxing factor produced during inflammation', Nature Medicine, vol. 16, pp. 279 - 285, http://dx.doi.org/10.1038/nm.2092
    Journal articles | 2010
    Associate Professor Shane Thomas
    Terentis AC; Freewan M; Sempertegui Plaza T; Raftery MJ; Stocker R; Thomas SR, 2010, 'The selenazal drug ebselen potently inhibits indoleamine 2,3-dioxygenase by targeting enzyme cysteine residues', Biochemistry, vol. 49, pp. 591 - 600, http://dx.doi.org/10.1021/bi901546e
    Journal articles | 2010
    Associate Professor Shane Thomas
    Wang Y; Liu H; McKenzie G; Witting PK; Stasch JP; Hahn M; Changsirivathanathamrong D; Wu BJ; Ball HJ; Thomas SR; Kapoor V; Celermajer DS; Mellor AL; Keaney JF; Hunt NH; Stocker R, 2010, 'Erratum: Kynurenine is an endothelium-derived relaxing factor produced during inflammation (Nature Medicine (2010) 16 (279-285))', Nature Medicine, vol. 16, pp. 607, http://dx.doi.org/10.1038/nm0510-607a
    Journal articles | 2009
    Associate Professor Shane Thomas
    Wang Y; Liu H; McKenzie G; Witting PK; Stasch J-P; Hahn M; Jackman KA; Changsirivathanathamrong D; Wu BJ; Ball HJ; Thomas SR; Celermajer DS; Mellor AL; Sobey CG; Keaney JF; Hunt NH; Stocker R, 2009, 'Kynurenine is a novel endothelium-derived vascular relaxing factor produced during inflammation', BMC Pharmacology, vol. 9, http://dx.doi.org/10.1186/1471-2210-9-s1-s39
    Journal articles | 2008
    Associate Professor Shane Thomas
    Schulz E; Dopheide J; Schuhmacher S; Thomas SR; Chen K; Daiber A; Wenzel P; Münzel T; Keaney JF, 2008, 'Suppression of the JNK pathway by induction of a metabolic stress response prevents vascular injury and dysfunction', Circulation, vol. 118, pp. 1347 - 1357, http://dx.doi.org/10.1161/CIRCULATIONAHA.108.784298
    Journal articles | 2008
    Associate Professor Shane Thomas
    Thomas SR; Witting P; Drummond G, 2008, 'Redox control of endothelial function and dysfunction: Molecular mechanisms and therapeutic opportunities', Antioxidants and Redox Signaling, vol. 10, pp. 1713 - 1765, http://dx.doi.org/10.1089/ars.2008.2027
    Journal articles | 2008
    Associate Professor Shane Thomas
    Lim SY; Raftery MJ; Cai H; Hsu KK; Yan WX; Hseih H; Watts RN; Richardson D; Thomas SR; Perry MA; Geczy C, 2008, 'S-nitrosylated S100A8: Novel anti-inflammatory properties', Journal of Immunology, vol. 181, pp. 5627 - 5636, http://dx.doi.org/10.4049/jimmunol.181.8.5627
    Journal articles | 2008
    Associate Professor Shane Thomas
    Maghzal G; Thomas SB; Hunt N; Stocker R, 2008, 'Cytochrome b(5), not superoxide anion radical, is a major reductant of indoleamine 2,3-dioxygenase in human cells', The Journal of Biological Chemistry, vol. 283, pp. 12014 - 12025, http://dx.doi.org/10.1074/jbc.M710266200
    Journal articles | 2008
    Associate Professor Shane Thomas
    Maghzal GJ; Thomas SR; Hunt NH; Stocker R, 2008, 'Cytochrome b5, Not Superoxide Anion Radical, Is a Major Reductant of Indoleamine 2,3-Dioxygenase in Human Cells', The Journal of Biological Chemistry, vol. 285, pp. 12014 - 12025, http://dx.doi.org/10.1074/jbc.M710266200
    Journal articles | 2007
    Associate Professor Shane Thomas
    Thomas SR; Terentis AC; Cai H; Takikawa O; Lay PA; Freewan M; Stocker R, 2007, 'Post-translational regulation of human indoleamine 2,3-dioxygenase activity by nitric oxide', The Journal of Biological Chemistry, vol. 282, pp. 23778 - 23787, http://dx.doi.org/10.1074/jbc.M700669200
    Journal articles | 2007
    Associate Professor Shane Thomas
    King NJ; Thomas SR, 2007, 'Molecules in focus: Indoleamine 2,3-dioxygenase', International Journal of Biochemistry and Cell Biology, vol. 39, pp. 2167 - 2172, http://dx.doi.org/10.1016/j.biocel.2007.01.004
    Journal articles | 2006
    Associate Professor Shane Thomas
    Thomas SR; Schulz E; Keaney JF, 2006, 'Hydrogen peroxide restrains endothelium-derived nitric oxide bioactivity - Role for iron-dependent oxidative stress', Free Radical Biology and Medicine, vol. 41, pp. 681 - 688, http://dx.doi.org/10.1016/j.freeradbiomed.2006.05.012
    Journal articles | 2005
    Associate Professor Shane Thomas
    Choy K; Beck K; Png F; Wu BJ; Leichtweis S; Thomas SR; Hou JY; Croft KD; Mori T; Stocker R, 2005, 'Processes involved in the site-specific effect of probucol on atherosclerosis in apolipoprotein E gene knockout mice', Arteriosclerosis, Thrombosis and Vascular Biology, vol. 25, pp. 1684 - 1690, http://dx.doi.org/10.1161/01.ATV.0000174125.89058.b6
    Journal articles | 2004
    Associate Professor Shane Thomas
    Anter E; Thomas SR; Schulz E; Shapira OM; Vita JA; Keaney Jr JF, 2004, 'Activation of Endothelial Nitric-oxide Synthase by the p38 MAPK in Response to Black Tea Polyphenols', The Journal of Biological Chemistry, vol. 279, pp. 46637 - 46643, http://dx.doi.org/10.1074/jbc.M405547200
    Journal articles | 2004
    Associate Professor Shane Thomas
    Aitken JB; Thomas SE; Stocker R; Thomas SR; Takikawa O; Armstrong RS; Lay P, 2004, 'Determination of the nature of the heme environment in nitrosyl indoleamine 2,3-dioxygenase using multiple-scattering analyses of XAFS.', Biochemistry, vol. 43, pp. 4892 - 4898, http://dx.doi.org/10.1021/bi049645s
    Journal articles | 2004
    Associate Professor Shane Thomas
    Chen K; Thomas SR; Albano A; Murphy MP; Keaney Jr JF, 2004, 'Mitochondrial function is required for hydrogen peroxide-induced growth factor receptor transactivation and downstream signaling', The Journal of Biological Chemistry, vol. 279, pp. 35079 - 35086, http://dx.doi.org/10.1074/jbc.M404859200
    Journal articles | 2004
    Associate Professor Shane Thomas
    Heydrick SJ; Weiss N; Thomas SR; Cap AP; Pimentel DR; Loscalzo J; Keaney Jr JF, 2004, 'L-Homocysteine and L-homocystine stereospecifically induce endothelial nitric oxide synthase-dependent lipid peroxidation in endothelial cells', Free Radical Biology and Medicine, vol. 36, pp. 632 - 640, http://dx.doi.org/10.1016/j.freeradbiomed.2003.12.001
    Journal articles | 2004
    Associate Professor Shane Thomas
    Stocker R; Huang A; Jeranian E; Hou JY; Wu T; Thomas SR; Keaney JF, 2004, 'Hypochlorous acid impairs EDNO bioactivity through a superoxide-dependent mechanism.', Arteriosclerosis, Thrombosis and Vascular Biology, vol. 24, pp. 2028 - 2033, http://dx.doi.org/10.1161/01.ATV.0000143388.20994.fa
    Journal articles | 2004
    Associate Professor Shane Thomas
    Thomas SR; Keaney JF; Stocker R, 2004, 'Redox regulation of vascular cell function', Journal of Molecular and Cellular Cardiology, vol. 37, pp. 322 - 323, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000222965000529&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
    Journal articles | 2003
    Associate Professor Shane Thomas
    Thomas SR; Chen K; Keaney Jr JF, 2003, 'Oxidative stress and endothelial nitric oxide bioactivity', Antioxidants and Redox Signaling, vol. 5, pp. 181 - 194, http://dx.doi.org/10.1089/152308603764816541
    Journal articles | 2003
    Associate Professor Shane Thomas
    Chen K; Thomas SR; Keaney Jr JF, 2003, 'Beyond LDL oxidation: ROS in vascular signal transduction', Free Radical Biology and Medicine, vol. 35, pp. 117 - 132, http://dx.doi.org/10.1016/S0891-5849(03)00239-9
    Journal articles | 2003
    Associate Professor Shane Thomas
    Vita JA; Gocke N; Duffy SJ; Kahn D; Tomasian D; Palmisano J; Thomas SR; Holbrook M; Keaney Jr JF, 2003, 'Effect of atorvastatin on endothelium-dependent vasodilation in patients with coronary artery disease', American Journal of Cardiology, vol. 91, pp. 857 - 860, http://dx.doi.org/10.1016/S0002-9149(03)00019-5
    Journal articles | 2002
    Associate Professor Shane Thomas
    Terentis AC; Thomas SR; Burr JA; Liebler DC; Stocker R, 2002, 'Vitamin E oxidation in human atherosclerotic lesions', Circulation Research, vol. 90, pp. 333 - 339, http://dx.doi.org/10.1161/hh0302.104454
    Journal articles | 2002
    Associate Professor Shane Thomas
    Thomas SR; Chen K; Keaney JF, 2002, 'Hydrogen peroxide activates endothelial nitric-oxide synthase through coordinated phosphorylation and dephosphorylation via a phosphoinositide 3-kinase-dependent signaling pathway', Journal of Biological Chemistry, vol. 277, pp. 6017 - 6024, http://dx.doi.org/10.1074/jbc.M109107200
    Journal articles | 2002
    Associate Professor Shane Thomas
    Kim H-S; Skurk C; Thomas SR; Bialik A; Suhara T; Kureishi Y; Birnbaum M; Keaney Jr JF; Walsh K, 2002, 'Regulation of angiogenesis by glycogen synthase kinase-3beta', The Journal of Biological Chemistry, vol. 277, pp. 41888 - 41896, http://dx.doi.org/10.1074/jbc.M206657200
    Journal articles | 2002
    Associate Professor Shane Thomas
    Terentis AC; Thomas SR; Takikawa O; Littlejohn TK; Truscott RJW; Armstrong RS; Stocker SRYR, 2002, 'The heme environment of recombinant human indoleamine 2,3-dioxygenase. Structural properties and substrate-ligand interactions', Journal of Biological Chemistry, vol. 277, pp. 15788 - 15794, http://dx.doi.org/10.1074/jbc.M200457200
    Journal articles | 2002
    Associate Professor Shane Thomas
    Huang A; Thomas SR; Keaney JF, 2002, 'Measurements of redox control of nitric oxide bioavailability', Methods in Enzymology, vol. 359, pp. 209 - 216, http://dx.doi.org/10.1016/S0076-6879(02)59185-0
    Journal articles | 2001
    Associate Professor Shane Thomas
    Carr AC; Hawkins CL; Thomas SR; Stocker R; Frei B, 2001, 'Relative reactivities of N-chloramines and hypochlorous acid with human plasma constituents', Free Radical Biology and Medicine, vol. 30, pp. 526 - 536, http://dx.doi.org/10.1016/S0891-5849(00)00495-0
    Journal articles | 2001
    Associate Professor Shane Thomas
    Thomas SR; Salahifar H; Mashima R; Hunt NH; Richardson DR; Stocker R, 2001, 'Antioxidants inhibit indoleamine 2,3-dioxygenase in IFN-γ-activated human macrophages: Posttranslational regulation by pyrrolidine dithiocarbamate', Journal of Immunology, vol. 166, pp. 6332 - 6340, http://dx.doi.org/10.4049/jimmunol.166.10.6332
    Journal articles | 2001
    Associate Professor Shane Thomas
    Thomas SR; Leichtweis SB; Pettersson K; Croft KD; Mori TA; Brown AJ; Stocker R, 2001, 'Dietary cosupplementation with vitamin E and coenzyme Q10 inhibits atherosclerosis in apolipoprotein E gene knockout mice', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 21, pp. 585 - 593, http://dx.doi.org/10.1161/01.ATV.21.4.585
    Journal articles | 2000
    Associate Professor Shane Thomas
    Thomas SR; Stocker R, 2000, 'Molecular action of vitamin E in lipoprotein oxidation: Implications for atherosclerosis', Free Radical Biology and Medicine, vol. 28, pp. 1795 - 1805, http://dx.doi.org/10.1016/S0891-5849(00)00236-7
    Journal articles | 2000
    Associate Professor Shane Thomas
    Stocker R; Witting P; Upston J; Thomas S; Terentis A; Lau A; Leichtweis S; Chafour X; Burr J; Liebler D; Pettersson K, 2000, 'Evidence for dissociation of lipoprotein lipid oxidation and atherosclerosis in different animals', Atherosclerosis, vol. 151, pp. 234 - 234, http://dx.doi.org/10.1016/s0021-9150(00)81061-8
    Journal articles | 1999
    Associate Professor Shane Thomas
    Thomas SR; Witting PK; Stocker R, 1999, 'A role for reduced coenzyme Q in atherosclerosis?', BioFactors, vol. 9, pp. 207 - 224, http://dx.doi.org/10.1002/biof.5520090216
    Journal articles | 1999
    Associate Professor Shane Thomas
    Thomas SR; Stocker R, 1999, 'Redox reactions related to indoleamine 2,3-dioxygenase and tryptophan metabolism along the kynurenine pathway', Redox Report, vol. 4, pp. 199 - 220, http://dx.doi.org/10.1179/135100099101534927
    Journal articles | 1999
    Associate Professor Shane Thomas
    Terentis AC; Thomas SR; Burr JA; Liebler DC; Stocker R, 1999, 'Alpha-tocopherol oxidation products in atherosclerotic lesions', FREE RADICAL BIOLOGY AND MEDICINE, vol. 27, pp. S99 - S99, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000083598900331&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 1999
    Associate Professor Shane Thomas
    Thomas SR; Terentis AC; Takikawa O; Hunt NH; Stocker R, 1999, 'Antioxidant activity and redox control of oxidative tryptophan metabolism in IFNG-primed macrophages', FREE RADICAL BIOLOGY AND MEDICINE, vol. 27, pp. S56 - S56, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000083598900174&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 1998
    Associate Professor Shane Thomas
    Sanni LA; Thomas SR; Tattam BN; Moore DE; Chaudhri G; Stocker R; Hunt NH, 1998, 'Dramatic changes in oxidative tryptophan metabolism along the kynurenine pathway in experimental cerebral and noncerebral malaria', American Journal of Pathology, vol. 152, pp. 611 - 619
    Journal articles | 1998
    Associate Professor Shane Thomas
    Thomas SR; Davies MJ; Stocker R, 1998, 'Oxidation and antioxidation of human low-density lipoprotein and plasma exposed to 3-morpholinosydnonimine and reagent peroxynitrite', Chemical Research in Toxicology, vol. 11, pp. 484 - 494, http://dx.doi.org/10.1021/tx970173a
    Journal articles | 1997
    Associate Professor Shane Thomas
    Neužil J; Thomas SR; Stocker R, 1997, 'Requirement for, promotion, or inhibition by α-tocopherol of radical- induced initiation of plasma lipoprotein lipid peroxidation', Free Radical Biology and Medicine, vol. 22, pp. 57 - 71, http://dx.doi.org/10.1016/S0891-5849(96)00224-9
    Journal articles | 1997
    Associate Professor Shane Thomas
    Thomas SR; Davies MJ; Stocker R, 1997, 'Peroxynitrite oxidises LDL lipids via tocopherol-mediated peroxidation', ATHEROSCLEROSIS, vol. 134, pp. 218 - 218, http://dx.doi.org/10.1016/S0021-9150(97)89169-1
    Journal articles | 1997
    Associate Professor Shane Thomas
    Thomas SR; Witting PK; Stocker R, 1997, 'Macrophage-derived 3-hydroxyanthranilate synergises with vitamin E in inhibiting LDL lipid peroxidation', ATHEROSCLEROSIS, vol. 134, pp. 236 - 236, http://dx.doi.org/10.1016/S0021-9150(97)89256-8
    Journal articles | 1996
    Associate Professor Shane Thomas
    Thomas SR; Witting PK; Stocker R, 1996, '3-Hydroxyanthranilic acid is an efficient, cell-derived co-antioxidant for α-tocopherol, inhibiting human low density lipoprotein and plasma lipid peroxidation', Journal of Biological Chemistry, vol. 271, pp. 32714 - 32721, http://dx.doi.org/10.1074/jbc.271.51.32714
    Journal articles | 1996
    Associate Professor Shane Thomas
    Thomas SR; Neužil J; Stocker R, 1996, 'Cosupplementation with Coenzyme Q Prevents the Prpoxidant Effect of α-Tocopherol and Increases the Resistance of LDL to Transition Metal-Dependent Oxidation Initiation', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 16, pp. 687 - 696, http://dx.doi.org/10.1161/01.ATV.16.5.687
    Journal articles | 1995
    Associate Professor Shane Thomas
    Stocker R; Thomas SR; Upston JM; Neuzil J, 1995, 'Tocopherol-mediated lipid peroxidation of isolated LDL and human plasma exposed to various radical oxidants', Atherosclerosis, vol. 115, pp. S40 - S40, http://dx.doi.org/10.1016/0021-9150(95)96411-k
    Journal articles | 1995
    Associate Professor Shane Thomas
    Thomas SR; Neuzil J; Mohr D; Stocker R, 1995, 'Coantioxidants make alpha-tocopherol an efficient antioxidant for low-density lipoprotein.', Am J Clin Nutr, vol. 62, pp. 1357S - 1364S, http://dx.doi.org/10.1093/ajcn/62.6.1357S
    Journal articles | 1994
    Associate Professor Shane Thomas
    Christen S; Thomas SR; Garner B; Stocker R, 1994, 'Inhibition by interferon-γ of human mononuclear cell-mediated low density lipoprotein oxidation. Participation of tryptophan metabolism along the kynurenine pathway', Journal of Clinical Investigation, vol. 93, pp. 2149 - 2158, http://dx.doi.org/10.1172/JCI117211
    Journal articles | 1994
    Associate Professor Shane Thomas
    Thomas SR; Mohr D; Stocker R, 1994, 'Nitric oxide inhibits indoleamine 2,3-dioxygenase activity in interferon- γ primed mononuclear phagocytes', Journal of Biological Chemistry, vol. 269, pp. 14457 - 14464
    Journal articles | 2021
    Associate Professor Shane Thomas
    Maiocchi S; Ku J; Hawtrey T; De Silvestro I; Malle E; Rees M; Thomas SR; Morris JC, 2021, 'Polyamine-Conjugated Nitroxides Are Efficacious Inhibitors of Oxidative Reactions Catalyzed by Endothelial-Localized Myeloperoxidase', Chemical Research in Toxicology, vol. 34, pp. 1681 - 1692, http://dx.doi.org/10.1021/acs.chemrestox.1c00094
    Journal articles | 2021
    Associate Professor Shane Thomas
    Maiocchi SL; Ku J; Thai T; Chan E; Rees MD; Thomas SR, 2021, 'Myeloperoxidase: A versatile mediator of endothelial dysfunction and therapeutic target during cardiovascular disease', Pharmacology and Therapeutics, vol. 221, pp. 107711, http://dx.doi.org/10.1016/j.pharmthera.2020.107711
    Journal articles | 2021
    Associate Professor Shane Thomas
    Thai T; Zhong F; Dang L; Chan E; Ku J; Malle E; Geczy CL; Keaney JF; Thomas SR, 2021, 'Endothelial-transcytosed myeloperoxidase activates endothelial nitric oxide synthase via a phospholipase C-dependent calcium signaling pathway', Free Radical Biology and Medicine, vol. 166, pp. 255 - 264, http://dx.doi.org/10.1016/j.freeradbiomed.2020.12.448
    Journal articles | 2020
    Associate Professor Shane Thomas
    Capraro A; Whan R; Thomas S; Jaffe A; Bridge W; Waters S, 2020, 'Novel Antioxidant Therapy with the Immediate Precursor to Glutathione, -Glutamylcysteine (GGC), Ameliorates LPS-Induced Cellular Stress in In Vitro 3D-Differentiated Airway Model from Primary Cystic Fibrosis Human Bronchial Cells', Antioxidants, http://dx.doi.org/10.3390/antiox9121204
    Journal articles | 2020
    Associate Professor Shane Thomas
    El Kazzi M; Rayner BS; Chami B; Dennis JM; Thomas SR; Witting PK, 2020, 'Neutrophil-mediated cardiac damage after acute myocardial infarction: Significance of defining a new target cell type for developing cardioprotective drugs', Antioxidants and Redox Signaling, vol. 33, pp. 689 - 712, http://dx.doi.org/10.1089/ars.2019.7928
    Journal articles | 2019
    Associate Professor Shane Thomas
    Lim YJ; Foo TC; Yeung AWS; Tu X; Ma Y; Hawkins CL; Witting PK; Jameson GNL; Terentis AC; Thomas SR, 2019, 'Human Indoleamine 2,3-Dioxygenase 1 Is an Efficient Mammalian Nitrite Reductase', Biochemistry, vol. 58, pp. 974 - 986, http://dx.doi.org/10.1021/acs.biochem.8b01231
    Journal articles | 2019
    Associate Professor Shane Thomas
    Rodrigo C; Tedla N; Thomas S; Polly P; Herbert C; Velan G; Saunders DN, 2019, 'Using Narratives to Teach Students Enrolled in Science and Medical Science Bachelor’s Degree Programs', Medical Science Educator, vol. 29, pp. 357 - 361, http://dx.doi.org/10.1007/s40670-019-00698-1
    Journal articles | 2018
    Associate Professor Shane Thomas
    Ramarathinam SH; Gras S; Alcantara S; Yeung AWS; Mifsud NA; Sonza S; Illing PT; Glaros EN; Center RJ; Thomas SR; Kent SJ; Ternette N; Purcell DFJ; Rossjohn J; Purcell AW, 2018, 'Identification of Native and Posttranslationally Modified HLA-B*57:01-Restricted HIV Envelope Derived Epitopes Using Immunoproteomics', Proteomics, vol. 18, http://dx.doi.org/10.1002/pmic.201700253
    Journal articles | 2018
    Associate Professor Shane Thomas
    Manuneedhi Cholan P; Cartland SP; Dang L; Rayner BS; Patel S; Thomas SR; Kavurma MM, 2018, 'TRAIL protects against endothelial dysfunction in vivo and inhibits angiotensin-II-induced oxidative stress in vascular endothelial cells in vitro', Free Radical Biology and Medicine, vol. 126, pp. 341 - 349, http://dx.doi.org/10.1016/j.freeradbiomed.2018.08.031
    Journal articles | 2018
    Associate Professor Shane Thomas
    Guiney L; Liou K; Li J; Thomas S; Glaros E; Ooi S, 2018, 'Acute Activation of Polymorphonuclear Granulocyte During Percutaneous Coronary Intervention: Comparison of Myeloperoxidase and Elastase Release and Elimination Kinetics', Heart, Lung and Circulation, vol. 27, pp. S434 - S434, http://dx.doi.org/10.1016/j.hlc.2018.06.882
    Journal articles | 2018
    Associate Professor Shane Thomas
    Manuneedhi Cholan P; Cartland S; Rayner B; Genner S; Dang L; Thomas S; Kavurma M, 2018, 'Abstract 055: TRAIL Protects Against Endothelial Dysfunction in vivo and Inhibits Angiotensin-II Induced Oxidative Stress in Vascular Endothelial Cells in vitro', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 38, http://dx.doi.org/10.1161/atvb.38.suppl_1.055
    Journal articles | 2018
    Associate Professor Shane Thomas
    Manuneedhi Cholan P; Cartland S; Rayner B; Genner S; Dang L; Thomas S; Kavurma M, 2018, 'Abstract 302: TRAIL Protects Against Endothelial Dysfunction in vivo and Inhibits Angiotensin-II Induced Oxidative Stress in Vascular Endothelial Cells in vitro', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 38, http://dx.doi.org/10.1161/atvb.38.suppl_1.302
    Journal articles | 2018
    Associate Professor Shane Thomas
    Liou K; Li J; Guiney L; Thomas S; Glaros E; Ooi S, 2018, 'Coronary Myeloperoxidase Provides Superior Characterisation of Coronary Inflammation in Patients Undergoing Percutaneous Coronary Interventions in the Setting of Non-ST Elevation Acute Coronary Syndrome', Heart, Lung and Circulation, vol. 27, pp. S311 - S311, http://dx.doi.org/10.1016/j.hlc.2018.06.598
    Journal articles | 2017
    Associate Professor Shane Thomas
    Cartland SP; Harith HH; Genner SW; Dang L; Cogger VC; Vellozzi M; Di Bartolo BA; Thomas SR; Adams LA; Kavurma MM, 2017, 'Non-alcoholic fatty liver disease, vascular inflammation and insulin resistance are exacerbated by TRAIL deletion in mice', Scientific Reports, vol. 7, http://dx.doi.org/10.1038/s41598-017-01721-4
    Journal articles | 2017
    Associate Professor Shane Thomas
    Maiocchi SL; Morris JC; Rees MD; Thomas SR, 2017, 'Regulation of the nitric oxide oxidase activity of myeloperoxidase by pharmacological agents', Biochemical Pharmacology, vol. 135, pp. 90 - 115, http://dx.doi.org/10.1016/j.bcp.2017.03.016
    Journal articles | 2016
    Associate Professor Shane Thomas
    Tran J; Magenau A; Rodriguez M; Rentero C; Royo T; Enrich C; Thomas SR; Grewal T; Gaus K, 2016, 'Activation of endothelial nitric oxide (eNOS) occurs through different membrane domains in endothelial cells', PLoS ONE, vol. 11, http://dx.doi.org/10.1371/journal.pone.0151556
    Journal articles | 2016
    Associate Professor Shane Thomas
    Thomas SR, 2016, 'Haematopoietic-expressed C/EBPβ: A novel transcriptional regulator of hepatic liver metabolism and macrophage foam cells during atherosclerosis?', Atherosclerosis, vol. 250, pp. 183 - 185, http://dx.doi.org/10.1016/j.atherosclerosis.2016.05.015
    Journal articles | 2016
    Associate Professor Shane Thomas
    Huang Y; Thoms JAI; Tursky ML; Knezevic K; Beck D; Chandrakanthan V; Suryani S; Olivier J; Boulton A; Glaros EN; Thomas SR; Lock RB; MacKenzie KL; Bushweller JH; Wong JWH; Pimanda JE, 2016, 'MAPK/ERK2 phosphorylates ERG at serine 283 in leukemic cells and promotes stem cell signatures and cell proliferation', Leukemia, vol. 30, pp. 1552 - 1561, http://dx.doi.org/10.1038/leu.2016.55
    Journal articles | 2016
    Associate Professor Shane Thomas
    Liou K; Jepson N; Buckley N; Chen V; Thomas S; Russell EA; Ooi SY, 2016, 'Design and Rationale for the Endothelin-1 Receptor Antagonism in the Prevention of Microvascular Injury in Patients with non-ST Elevation Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention (ENDORA-PCI) Trial', Cardiovascular Drugs and Therapy, vol. 30, pp. 169 - 175, http://dx.doi.org/10.1007/s10557-016-6641-x
    Journal articles | 2016
    Associate Professor Shane Thomas
    Harith H; Cartland S; Di Bartolo B; Dang L; Thomas S; Kavurma M, 2016, 'Abstract 614: TRAIL Deletion in Mice Promotes Vascular Insulin Resistance', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 36, http://dx.doi.org/10.1161/atvb.36.suppl_1.614
    Journal articles | 2016
    Associate Professor Shane Thomas
    Thoms JAI; Knezevic K; Liu JJ; Glaros EN; Thai T; Qiao Q; Campbell H; Packham D; Huang Y; Papathanasiou P; Tunningley R; Whittle B; Yeung AWS; Chandrakanthan V; Hesson L; Chen V; Wong JWH; Purton LE; Ward RL; Thomas SR; Pimanda JE, 2016, 'Arrested hematopoiesis and vascular relaxation defects in mice with a mutation in Dhfr', Molecular and Cellular Biology, vol. 36, pp. 1222 - 1236, http://dx.doi.org/10.1128/MCB.01035-15
    Journal articles | 2016
    Associate Professor Shane Thomas
    Yeung AWS; Lim YJ; Hastad M; Dang L; Örfi L; Szabadkai I; Kéri G; Terentis AC; King NJC; Witting PK; Thomas SR, 2016, 'Redox Control of the Critical Immune Regulatory Enzyme Indoleamine 2,3-Dioxygenase by NADPH Oxidase 2-Derived Reactive Oxygen Species in Human Monocytes', Free Radical Biology and Medicine, vol. 100, pp. S62 - S62, http://dx.doi.org/10.1016/j.freeradbiomed.2016.10.162
    Journal articles | 2015
    Associate Professor Shane Thomas
    Yeung AWS; Terentis AC; King NJC; Thomas SR, 2015, 'Role of indoleamine 2,3-dioxygenase in health and disease', Clinical Science, vol. 129, pp. 601 - 672, http://dx.doi.org/10.1042/CS20140392
    Journal articles | 2015
    Associate Professor Shane Thomas
    Das T; Kutty SK; Tavallaie R; Ibugo AI; Panchompoo J; Sehar S; Aldous L; Yeung AWS; Thomas SR; Kumar N; Gooding JJ; Manefield M, 2015, 'Phenazine virulence factor binding to extracellular DNA is important for Pseudomonas aeruginosa biofilm formation', Scientific Reports, vol. 5, http://dx.doi.org/10.1038/srep08398
    Journal articles | 2015
    Associate Professor Shane Thomas
    Di Bartolo BA; Cartland SP; Prado-Lourenco L; Griffith TS; Gentile C; Ravindran J; Azahri NSM; Thai T; Yeung AWS; Thomas SR; Kavurma MM, 2015, 'Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) promotes angiogenesis and ischemia-induced neovascularization via NADPH oxidase 4 (NOX4) and nitric oxide-dependent mechanisms', Journal of the American Heart Association, vol. 4, http://dx.doi.org/10.1161/JAHA.115.002527
    Journal articles | 2015
    Associate Professor Shane Thomas
    Nasrallah R; Knezevic K; Thai T; Thomas SR; Göttgens B; Lacaud G; Kouskoff V; Pimanda JE, 2015, 'Endoglin potentiates nitric oxide synthesis to enhance definitive hematopoiesis', Biology Open, vol. 4, pp. 819 - 829, http://dx.doi.org/10.1242/bio.011494
    Journal articles | 2015
    Associate Professor Shane Thomas
    Rees MD; Thomas SR, 2015, 'Using cell-substrate impedance and live cell imaging to measure real-time changes in cellular adhesion and de-adhesion induced by matrix modification', Journal of Visualized Experiments, http://dx.doi.org/10.3791/52423
    Journal articles | 2015
    Associate Professor Shane Thomas
    Rees MD; Thomas SR, 2015, 'Using cell-substrate impedance and live cell imaging to measure real-time changes in cellular adhesion and de-adhesion induced by matrix modification', Journal of visualized experiments : JoVE, http://dx.doi.org/10.3791/52423
    Journal articles | 2014
    Associate Professor Shane Thomas
    Rees MD; Maiocchi SL; Kettle AJ; Thomas SR, 2014, 'Mechanism and regulation of peroxidase-catalyzed nitric oxide consumption in physiological fluids: Critical protective actions of ascorbate and thiocyanate', Free Radical Biology and Medicine, vol. 72, pp. 91 - 103, http://dx.doi.org/10.1016/j.freeradbiomed.2014.03.037
    Journal articles | 2014
    Associate Professor Shane Thomas
    Cochran BJ; Bisoendial RJ; Hou L; Glaros E; Rossy J; Thomas SR; Barter PJ; Rye KA, 2014, 'Apolipoprotein a-I increases insulin secretion and production from pancreatic β-cells via a g-protein-camp-PKA-FOXO1-dependent mechanism', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 34, pp. 2261 - 2267, http://dx.doi.org/10.1161/ATVBAHA.114.304131
    Journal articles | 2014
    Associate Professor Shane Thomas
    Stapelberg M; Zobalova R; Nguyen MN; Walker T; Stantic M; Goodwin J; Pasdar EA; Thai T; Prokopova K; Yan B; Hall S; De Pennington N; Thomas SR; Grant G; Stursa J; Bajzikova M; Meedeniya ACB; Truksa J; Ralph SJ; Ansorge O; Dong LF; Neuzil J, 2014, 'Indoleamine-2,3-dioxygenase elevated in tumor-initiating cells is suppressed by mitocans', Free Radical Biology and Medicine, vol. 67, pp. 41 - 50, http://dx.doi.org/10.1016/j.freeradbiomed.2013.10.003
    Journal articles | 2014
    Associate Professor Shane Thomas
    Di Bartolo BA; Cartland SP; Prado-Lourenco L; Azahri NSM; Thai T; Yeung A; Thomas SR; Kavurma MM, 2014, 'Abstract 18060: TRAIL Promotes Angiogenesis and Ischemia-Induced Neovascularisation via NOX4, H2O2 and Nitric Oxide-Dependent Mechanisms', Circulation, vol. 130, http://dx.doi.org/10.1161/circ.130.suppl_2.18060
    Journal articles | 2014
    Associate Professor Shane Thomas
    Sherrah AG; Edelman JJB; Thomas SR; Brady PW; Wilson MK; Jeremy RW; Bannon PG; Vallely MP, 2014, 'The freestyle aortic bioprosthesis: A systematic review', Heart Lung and Circulation, vol. 23, pp. 1110 - 1117, http://dx.doi.org/10.1016/j.hlc.2014.04.262
    Journal articles | 2014
    Associate Professor Shane Thomas
    Maiocchi SL; Thomas SR; Rees MD, 2014, 'Regulation of the NO Oxidase Activity of Myeloperoxidase by Pharmacological Agents', FREE RADICAL BIOLOGY AND MEDICINE, vol. 76, pp. S17 - S17, http://dx.doi.org/10.1016/j.freeradbiomed.2014.10.497
    Journal articles | 2013
    Associate Professor Shane Thomas
    Rivera J; Walduck AK; Thomas SR; Glaros EN; Hooker EU; Guida E; Sobey CG; Drummond GR, 2013, 'Accumulation of serum lipids by vascular smooth muscle cells involves a macropinocytosis-like uptake pathway and is associated with the downregulation of the ATP-binding cassette transporter A1', Naunyn-Schmiedeberg's Archives of Pharmacology, vol. 386, pp. 1081 - 1093, http://dx.doi.org/10.1007/s00210-013-0909-5
    Journal articles | 2013
    Associate Professor Shane Thomas
    Sherrah AG; Edelman JJB; Thomas SR; Brady PW; Wilson MK; Jeremy RW; Bannon PG; Vallely MP, 2013, 'The Freestyle Aortic Bioprosthesis: A Systematic Review', Heart Lung and Circulation, http://dx.doi.org/10.1016/j.hlc.2014.04.262
    Journal articles | 2013
    Associate Professor Shane Thomas
    Freewan M; Rees MD; Sempertegui plaza T; Glaros EN; Lim YJ; Wang X; Yeung AWS; Witting PK; Terentis AC; Thomas SR, 2013, 'Human Indoleamine 2,3-dioxygenase is a catalyst of physiological heme peroxidase reactions: implications for the inhibition of dioxygenase activity by hydrogen peroxide', The Journal of Biological Chemistry, vol. 288, pp. 1548 - 1567, http://dx.doi.org/10.1074/jbc.M112.410993
    Journal articles | 2012
    Associate Professor Shane Thomas
    Getts DR; Terry RL; Teague Getts M; Muller M; Rana S; Deffrasnes C; Ashhurst TM; Radford J; Hofer M; Thomas SR; Campbell IL; King NJC, 2012, 'Targeted blockade in lethal West Nile virus encephalitis indicates a crucial role for very late antigen (VLA)-4-dependent recruitment of nitric oxide-producing macrophages', Journal of Neuroinflammation, vol. 9, http://dx.doi.org/10.1186/1742-2094-9-246
    Journal articles | 2012
    Associate Professor Shane Thomas
    Yeung AWC; Wu W; Freewan M; Stocker R; King NJC; Thomas SR, 2012, 'Flavivirus infection induces indoleamine 2,3-dioxygenase in human monocyte-derived macrophages via tumor necrosis factor and NF-êB', Journal of Leukocyte Biology, vol. 91, pp. 657 - 666, http://dx.doi.org/10.1189/jlb.1011532
    Journal articles | 2012
    Associate Professor Shane Thomas
    Li C; Lonn ME; Xu X; Magzhal G; Frazer D; Thomas SR; Halliwell B; Richardson DR; Anderson GJ; Stocker R, 2012, 'Sustained expression of heme oxygenase-1 alters iron homeostasis in nonerythroid cells', Free Radical Biology and Medicine, vol. 53, pp. 366 - 374, http://dx.doi.org/10.1016/j.freeradbiomed.2012.03.007
    Journal articles | 2011
    Associate Professor Shane Thomas
    Herbert AD; Ng H; Jessup W; Kockx M; Cartland SP; Thomas SR; Hogg PJ; Wargon O, 2011, 'Hypoxia regulates the production and activity of glucose transporter-1 and indoleamine 2,3-dioxygenase in monocyte-derived endothelial-like cells: possible relevance to infantile haemangioma pathogenesis', British Journal of Dermatology, vol. 164, pp. 308 - 315, http://dx.doi.org/10.1111/j.1365-2133.2010.10086.x/abstract
    Journal articles | 2011
    Associate Professor Shane Thomas
    Meotti FC; Jameson GNL; Turner R; Harwood D; Stockwell S; Rees MD; Thomas SR; Kettle AJ, 2011, 'Urate as a physiological substrate for myeloperoxidase: Implications for hyperuricemia and inflammation', The Journal of Biological Chemistry, vol. 286, pp. 12901 - 12911, http://dx.doi.org/10.1074/jbc.M110.172460
    Journal articles | 2011
    Associate Professor Shane Thomas
    Munoz-Erazo L; Yeung A; Madigan M; Thomas S; King N, 2011, 'BALANCE OF INDOLEAMINE 2,3 DIOXYGENASE AND INDUCIBLE NITRIC OXIDE SYNTHASE RESPONSES IN WEST NILE VIRUS-INFECTED HUMAN RETINAL PIGMENT EPITHELIUM', CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, vol. 39, pp. 87 - 87, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000296914400169&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 2010
    Associate Professor Shane Thomas
    Wang Y; Liu H; McKenzie GL; Witting PK; Stasch J; Hahn M; Changsirivathanathamrong D; Wu BJ; Ball HJ; Thomas SR; Kapoor V; Celermajer DS; Mellor AL; Keaney Jr JF; Hunt NH; Stocker R, 2010, 'Kynurenine is an endothelium-derived relaxing factor produced during inflammation', Nature Medicine, vol. 16, pp. 279 - 285, http://dx.doi.org/10.1038/nm.2092
    Journal articles | 2010
    Associate Professor Shane Thomas
    Terentis AC; Freewan M; Sempertegui Plaza T; Raftery MJ; Stocker R; Thomas SR, 2010, 'The selenazal drug ebselen potently inhibits indoleamine 2,3-dioxygenase by targeting enzyme cysteine residues', Biochemistry, vol. 49, pp. 591 - 600, http://dx.doi.org/10.1021/bi901546e
    Journal articles | 2010
    Associate Professor Shane Thomas
    Wang Y; Liu H; McKenzie G; Witting PK; Stasch JP; Hahn M; Changsirivathanathamrong D; Wu BJ; Ball HJ; Thomas SR; Kapoor V; Celermajer DS; Mellor AL; Keaney JF; Hunt NH; Stocker R, 2010, 'Erratum: Kynurenine is an endothelium-derived relaxing factor produced during inflammation (Nature Medicine (2010) 16 (279-285))', Nature Medicine, vol. 16, pp. 607, http://dx.doi.org/10.1038/nm0510-607a
    Journal articles | 2009
    Associate Professor Shane Thomas
    Wang Y; Liu H; McKenzie G; Witting PK; Stasch J-P; Hahn M; Jackman KA; Changsirivathanathamrong D; Wu BJ; Ball HJ; Thomas SR; Celermajer DS; Mellor AL; Sobey CG; Keaney JF; Hunt NH; Stocker R, 2009, 'Kynurenine is a novel endothelium-derived vascular relaxing factor produced during inflammation', BMC Pharmacology, vol. 9, http://dx.doi.org/10.1186/1471-2210-9-s1-s39
    Journal articles | 2008
    Associate Professor Shane Thomas
    Lim SY; Raftery MJ; Cai H; Hsu KK; Yan WX; Hseih H; Watts RN; Richardson D; Thomas SR; Perry MA; Geczy C, 2008, 'S-nitrosylated S100A8: Novel anti-inflammatory properties', Journal of Immunology, vol. 181, pp. 5627 - 5636, http://dx.doi.org/10.4049/jimmunol.181.8.5627
    Journal articles | 2008
    Associate Professor Shane Thomas
    Schulz E; Dopheide J; Schuhmacher S; Thomas SR; Chen K; Daiber A; Wenzel P; Münzel T; Keaney JF, 2008, 'Suppression of the JNK pathway by induction of a metabolic stress response prevents vascular injury and dysfunction', Circulation, vol. 118, pp. 1347 - 1357, http://dx.doi.org/10.1161/CIRCULATIONAHA.108.784298
    Journal articles | 2008
    Associate Professor Shane Thomas
    Thomas SR; Witting P; Drummond G, 2008, 'Redox control of endothelial function and dysfunction: Molecular mechanisms and therapeutic opportunities', Antioxidants and Redox Signaling, vol. 10, pp. 1713 - 1765, http://dx.doi.org/10.1089/ars.2008.2027
    Journal articles | 2008
    Associate Professor Shane Thomas
    Maghzal G; Thomas SB; Hunt N; Stocker R, 2008, 'Cytochrome b(5), not superoxide anion radical, is a major reductant of indoleamine 2,3-dioxygenase in human cells', The Journal of Biological Chemistry, vol. 283, pp. 12014 - 12025, http://dx.doi.org/10.1074/jbc.M710266200
    Journal articles | 2008
    Associate Professor Shane Thomas
    Maghzal GJ; Thomas SR; Hunt NH; Stocker R, 2008, 'Cytochrome b5, Not Superoxide Anion Radical, Is a Major Reductant of Indoleamine 2,3-Dioxygenase in Human Cells', The Journal of Biological Chemistry, vol. 285, pp. 12014 - 12025, http://dx.doi.org/10.1074/jbc.M710266200
    Journal articles | 2007
    Associate Professor Shane Thomas
    Thomas SR; Terentis AC; Cai H; Takikawa O; Lay PA; Freewan M; Stocker R, 2007, 'Post-translational regulation of human indoleamine 2,3-dioxygenase activity by nitric oxide', The Journal of Biological Chemistry, vol. 282, pp. 23778 - 23787, http://dx.doi.org/10.1074/jbc.M700669200
    Journal articles | 2007
    Associate Professor Shane Thomas
    King NJ; Thomas SR, 2007, 'Molecules in focus: Indoleamine 2,3-dioxygenase', International Journal of Biochemistry and Cell Biology, vol. 39, pp. 2167 - 2172, http://dx.doi.org/10.1016/j.biocel.2007.01.004
    Journal articles | 2006
    Associate Professor Shane Thomas
    Thomas SR; Schulz E; Keaney JF, 2006, 'Hydrogen peroxide restrains endothelium-derived nitric oxide bioactivity - Role for iron-dependent oxidative stress', Free Radical Biology and Medicine, vol. 41, pp. 681 - 688, http://dx.doi.org/10.1016/j.freeradbiomed.2006.05.012
    Journal articles | 2005
    Associate Professor Shane Thomas
    Choy K; Beck K; Png F; Wu BJ; Leichtweis S; Thomas SR; Hou JY; Croft KD; Mori T; Stocker R, 2005, 'Processes involved in the site-specific effect of probucol on atherosclerosis in apolipoprotein E gene knockout mice', Arteriosclerosis, Thrombosis and Vascular Biology, vol. 25, pp. 1684 - 1690, http://dx.doi.org/10.1161/01.ATV.0000174125.89058.b6
    Journal articles | 2004
    Associate Professor Shane Thomas
    Anter E; Thomas SR; Schulz E; Shapira OM; Vita JA; Keaney Jr JF, 2004, 'Activation of Endothelial Nitric-oxide Synthase by the p38 MAPK in Response to Black Tea Polyphenols', The Journal of Biological Chemistry, vol. 279, pp. 46637 - 46643, http://dx.doi.org/10.1074/jbc.M405547200
    Journal articles | 2004
    Associate Professor Shane Thomas
    Chen K; Thomas SR; Albano A; Murphy MP; Keaney Jr JF, 2004, 'Mitochondrial function is required for hydrogen peroxide-induced growth factor receptor transactivation and downstream signaling', The Journal of Biological Chemistry, vol. 279, pp. 35079 - 35086, http://dx.doi.org/10.1074/jbc.M404859200
    Journal articles | 2004
    Associate Professor Shane Thomas
    Heydrick SJ; Weiss N; Thomas SR; Cap AP; Pimentel DR; Loscalzo J; Keaney Jr JF, 2004, 'L-Homocysteine and L-homocystine stereospecifically induce endothelial nitric oxide synthase-dependent lipid peroxidation in endothelial cells', Free Radical Biology and Medicine, vol. 36, pp. 632 - 640, http://dx.doi.org/10.1016/j.freeradbiomed.2003.12.001
    Journal articles | 2004
    Associate Professor Shane Thomas
    Stocker R; Huang A; Jeranian E; Hou JY; Wu T; Thomas SR; Keaney JF, 2004, 'Hypochlorous acid impairs EDNO bioactivity through a superoxide-dependent mechanism.', Arteriosclerosis, Thrombosis and Vascular Biology, vol. 24, pp. 2028 - 2033, http://dx.doi.org/10.1161/01.ATV.0000143388.20994.fa
    Journal articles | 2004
    Associate Professor Shane Thomas
    Aitken JB; Thomas SE; Stocker R; Thomas SR; Takikawa O; Armstrong RS; Lay P, 2004, 'Determination of the nature of the heme environment in nitrosyl indoleamine 2,3-dioxygenase using multiple-scattering analyses of XAFS.', Biochemistry, vol. 43, pp. 4892 - 4898, http://dx.doi.org/10.1021/bi049645s
    Journal articles | 2004
    Associate Professor Shane Thomas
    Thomas SR; Keaney JF; Stocker R, 2004, 'Redox regulation of vascular cell function', Journal of Molecular and Cellular Cardiology, vol. 37, pp. 322 - 323, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000222965000529&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
    Journal articles | 2003
    Associate Professor Shane Thomas
    Thomas SR; Chen K; Keaney Jr JF, 2003, 'Oxidative stress and endothelial nitric oxide bioactivity', Antioxidants and Redox Signaling, vol. 5, pp. 181 - 194, http://dx.doi.org/10.1089/152308603764816541
    Journal articles | 2003
    Associate Professor Shane Thomas
    Chen K; Thomas SR; Keaney Jr JF, 2003, 'Beyond LDL oxidation: ROS in vascular signal transduction', Free Radical Biology and Medicine, vol. 35, pp. 117 - 132, http://dx.doi.org/10.1016/S0891-5849(03)00239-9
    Journal articles | 2003
    Associate Professor Shane Thomas
    Vita JA; Gocke N; Duffy SJ; Kahn D; Tomasian D; Palmisano J; Thomas SR; Holbrook M; Keaney Jr JF, 2003, 'Effect of atorvastatin on endothelium-dependent vasodilation in patients with coronary artery disease', American Journal of Cardiology, vol. 91, pp. 857 - 860, http://dx.doi.org/10.1016/S0002-9149(03)00019-5
    Journal articles | 2002
    Associate Professor Shane Thomas
    Terentis AC; Thomas SR; Burr JA; Liebler DC; Stocker R, 2002, 'Vitamin E oxidation in human atherosclerotic lesions', Circulation Research, vol. 90, pp. 333 - 339, http://dx.doi.org/10.1161/hh0302.104454
    Journal articles | 2002
    Associate Professor Shane Thomas
    Thomas SR; Chen K; Keaney JF, 2002, 'Hydrogen peroxide activates endothelial nitric-oxide synthase through coordinated phosphorylation and dephosphorylation via a phosphoinositide 3-kinase-dependent signaling pathway', Journal of Biological Chemistry, vol. 277, pp. 6017 - 6024, http://dx.doi.org/10.1074/jbc.M109107200
    Journal articles | 2002
    Associate Professor Shane Thomas
    Kim H-S; Skurk C; Thomas SR; Bialik A; Suhara T; Kureishi Y; Birnbaum M; Keaney Jr JF; Walsh K, 2002, 'Regulation of angiogenesis by glycogen synthase kinase-3beta', The Journal of Biological Chemistry, vol. 277, pp. 41888 - 41896, http://dx.doi.org/10.1074/jbc.M206657200
    Journal articles | 2002
    Associate Professor Shane Thomas
    Terentis AC; Thomas SR; Takikawa O; Littlejohn TK; Truscott RJW; Armstrong RS; Stocker SRYR, 2002, 'The heme environment of recombinant human indoleamine 2,3-dioxygenase. Structural properties and substrate-ligand interactions', Journal of Biological Chemistry, vol. 277, pp. 15788 - 15794, http://dx.doi.org/10.1074/jbc.M200457200
    Journal articles | 2002
    Associate Professor Shane Thomas
    Huang A; Thomas SR; Keaney JF, 2002, 'Measurements of redox control of nitric oxide bioavailability', Methods in Enzymology, vol. 359, pp. 209 - 216, http://dx.doi.org/10.1016/S0076-6879(02)59185-0
    Journal articles | 2001
    Associate Professor Shane Thomas
    Thomas SR; Salahifar H; Mashima R; Hunt NH; Richardson DR; Stocker R, 2001, 'Antioxidants inhibit indoleamine 2,3-dioxygenase in IFN-γ-activated human macrophages: Posttranslational regulation by pyrrolidine dithiocarbamate', Journal of Immunology, vol. 166, pp. 6332 - 6340, http://dx.doi.org/10.4049/jimmunol.166.10.6332
    Journal articles | 2001
    Associate Professor Shane Thomas
    Carr AC; Hawkins CL; Thomas SR; Stocker R; Frei B, 2001, 'Relative reactivities of N-chloramines and hypochlorous acid with human plasma constituents', Free Radical Biology and Medicine, vol. 30, pp. 526 - 536, http://dx.doi.org/10.1016/S0891-5849(00)00495-0
    Journal articles | 2001
    Associate Professor Shane Thomas
    Thomas SR; Leichtweis SB; Pettersson K; Croft KD; Mori TA; Brown AJ; Stocker R, 2001, 'Dietary cosupplementation with vitamin E and coenzyme Q10 inhibits atherosclerosis in apolipoprotein E gene knockout mice', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 21, pp. 585 - 593, http://dx.doi.org/10.1161/01.ATV.21.4.585
    Journal articles | 2000
    Associate Professor Shane Thomas
    Thomas SR; Stocker R, 2000, 'Molecular action of vitamin E in lipoprotein oxidation: Implications for atherosclerosis', Free Radical Biology and Medicine, vol. 28, pp. 1795 - 1805, http://dx.doi.org/10.1016/S0891-5849(00)00236-7
    Journal articles | 2000
    Associate Professor Shane Thomas
    Stocker R; Witting P; Upston J; Thomas S; Terentis A; Lau A; Leichtweis S; Chafour X; Burr J; Liebler D; Pettersson K, 2000, 'Evidence for dissociation of lipoprotein lipid oxidation and atherosclerosis in different animals', Atherosclerosis, vol. 151, pp. 234 - 234, http://dx.doi.org/10.1016/s0021-9150(00)81061-8
    Journal articles | 1999
    Associate Professor Shane Thomas
    Thomas SR; Stocker R, 1999, 'Redox reactions related to indoleamine 2,3-dioxygenase and tryptophan metabolism along the kynurenine pathway', Redox Report, vol. 4, pp. 199 - 220, http://dx.doi.org/10.1179/135100099101534927
    Journal articles | 1999
    Associate Professor Shane Thomas
    Thomas SR; Witting PK; Stocker R, 1999, 'A role for reduced coenzyme Q in atherosclerosis?', BioFactors, vol. 9, pp. 207 - 224, http://dx.doi.org/10.1002/biof.5520090216
    Journal articles | 1999
    Associate Professor Shane Thomas
    Terentis AC; Thomas SR; Burr JA; Liebler DC; Stocker R, 1999, 'Alpha-tocopherol oxidation products in atherosclerotic lesions', FREE RADICAL BIOLOGY AND MEDICINE, vol. 27, pp. S99 - S99, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000083598900331&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 1999
    Associate Professor Shane Thomas
    Thomas SR; Terentis AC; Takikawa O; Hunt NH; Stocker R, 1999, 'Antioxidant activity and redox control of oxidative tryptophan metabolism in IFNG-primed macrophages', FREE RADICAL BIOLOGY AND MEDICINE, vol. 27, pp. S56 - S56, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000083598900174&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 1998
    Associate Professor Shane Thomas
    Sanni LA; Thomas SR; Tattam BN; Moore DE; Chaudhri G; Stocker R; Hunt NH, 1998, 'Dramatic changes in oxidative tryptophan metabolism along the kynurenine pathway in experimental cerebral and noncerebral malaria', American Journal of Pathology, vol. 152, pp. 611 - 619
    Journal articles | 1998
    Associate Professor Shane Thomas
    Thomas SR; Davies MJ; Stocker R, 1998, 'Oxidation and antioxidation of human low-density lipoprotein and plasma exposed to 3-morpholinosydnonimine and reagent peroxynitrite', Chemical Research in Toxicology, vol. 11, pp. 484 - 494, http://dx.doi.org/10.1021/tx970173a
    Journal articles | 1997
    Associate Professor Shane Thomas
    Thomas SR; Davies MJ; Stocker R, 1997, 'Peroxynitrite oxidises LDL lipids via tocopherol-mediated peroxidation', ATHEROSCLEROSIS, vol. 134, pp. 218 - 218, http://dx.doi.org/10.1016/S0021-9150(97)89169-1
    Journal articles | 1997
    Associate Professor Shane Thomas
    Thomas SR; Witting PK; Stocker R, 1997, 'Macrophage-derived 3-hydroxyanthranilate synergises with vitamin E in inhibiting LDL lipid peroxidation', ATHEROSCLEROSIS, vol. 134, pp. 236 - 236, http://dx.doi.org/10.1016/S0021-9150(97)89256-8
    Journal articles | 1997
    Associate Professor Shane Thomas
    Neužil J; Thomas SR; Stocker R, 1997, 'Requirement for, promotion, or inhibition by α-tocopherol of radical- induced initiation of plasma lipoprotein lipid peroxidation', Free Radical Biology and Medicine, vol. 22, pp. 57 - 71, http://dx.doi.org/10.1016/S0891-5849(96)00224-9
    Journal articles | 1996
    Associate Professor Shane Thomas
    Thomas SR; Witting PK; Stocker R, 1996, '3-Hydroxyanthranilic acid is an efficient, cell-derived co-antioxidant for α-tocopherol, inhibiting human low density lipoprotein and plasma lipid peroxidation', Journal of Biological Chemistry, vol. 271, pp. 32714 - 32721, http://dx.doi.org/10.1074/jbc.271.51.32714
    Journal articles | 1996
    Associate Professor Shane Thomas
    Thomas SR; Neužil J; Stocker R, 1996, 'Cosupplementation with Coenzyme Q Prevents the Prpoxidant Effect of α-Tocopherol and Increases the Resistance of LDL to Transition Metal-Dependent Oxidation Initiation', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 16, pp. 687 - 696, http://dx.doi.org/10.1161/01.ATV.16.5.687
    Journal articles | 1995
    Associate Professor Shane Thomas
    Stocker R; Thomas SR; Upston JM; Neuzil J, 1995, 'Tocopherol-mediated lipid peroxidation of isolated LDL and human plasma exposed to various radical oxidants', Atherosclerosis, vol. 115, pp. S40 - S40, http://dx.doi.org/10.1016/0021-9150(95)96411-k
    Journal articles | 1995
    Associate Professor Shane Thomas
    Thomas SR; Neuzil J; Mohr D; Stocker R, 1995, 'Coantioxidants make alpha-tocopherol an efficient antioxidant for low-density lipoprotein.', Am J Clin Nutr, vol. 62, pp. 1357S - 1364S, http://dx.doi.org/10.1093/ajcn/62.6.1357S
    Journal articles | 1994
    Associate Professor Shane Thomas
    Thomas SR; Mohr D; Stocker R, 1994, 'Nitric oxide inhibits indoleamine 2,3-dioxygenase activity in interferon- γ primed mononuclear phagocytes', Journal of Biological Chemistry, vol. 269, pp. 14457 - 14464
    Journal articles | 1994
    Associate Professor Shane Thomas
    Christen S; Thomas SR; Garner B; Stocker R, 1994, 'Inhibition by interferon-γ of human mononuclear cell-mediated low density lipoprotein oxidation. Participation of tryptophan metabolism along the kynurenine pathway', Journal of Clinical Investigation, vol. 93, pp. 2149 - 2158, http://dx.doi.org/10.1172/JCI117211
  • Conference Papers | 2017
    Associate Professor Shane Thomas
    Maiocchi S; Rees M; Morris J; Thomas S, 2017, 'Endothelial-targeted Nitroxides Inhibit MPO-mediated Endothelial Dysfunction', in FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, Baltimore, MD, pp. 207 - 207, presented at 24th Annual Meeting of the Society-for-Redox-Biology-and-Medicine (SfRBM), Baltimore, MD, 29 November 2017 - 02 December 2017, http://dx.doi.org/10.1016/j.freeradbiomed.2017.10.328
    Conference Papers | 2017
    Associate Professor Shane Thomas
    Kang YC; Glaros E; Thomas S; Qiao Q; Brownlee C; Pimanda J; Chandrakanthan V, 2017, 'Identification of Novel Embryonic Vascular Stem-like cells and their role in Coronary Vasculature development and repair', in MECHANISMS OF DEVELOPMENT, ELSEVIER SCIENCE BV, Natil Univ Singapore, Singapore, SINGAPORE, pp. S48 - S49, presented at 18th International Congress of Developmental Biology, Natil Univ Singapore, Singapore, SINGAPORE, 18 June 2017 - 22 June 2017, http://dx.doi.org/10.1016/j.mod.2017.04.088
    Conference Papers | 2016
    Associate Professor Shane Thomas
    Dang L; Chan E; Thuan T; Glaros EN; Witting PK; Rees MD; Thomas SR, 2016, 'Endothelial-Transcytosed Myeloperoxidase Promotes Endothelial Dysfunction in an Oxidant Specific Manner: Novel Protective Actions of Thiocyanate and Nitrite', in FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, pp. S152 - S153, http://dx.doi.org/10.1016/j.freeradbiomed.2016.10.402
    Conference Papers | 2016
    Associate Professor Shane Thomas
    Lim YJ; Yeung AWS; Ma Y; Rees MD; Glaros EN; Hawkins CL; Jameson GNL; Witting PK; Terentis AC; Thomas SR, 2016, 'Indoleamine 2,3-Dioxygenase Is a Novel Mammalian Nitrite Reductase', in FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, pp. S61 - S61, http://dx.doi.org/10.1016/j.freeradbiomed.2016.10.161
    Conference Abstracts | 2015
    Associate Professor Shane Thomas
    Maiocchi S; Dang L; Morris J; Thomas S; Rees M, 2015, 'Inhibition of Myeloperoxidase-Mediated Endothelial Dysfunction by Nitroxides', in FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, Stuttgart, GERMANY, Vol. 86, pp. S28 - S29, presented at SFRR-E/SNFS Conference, Stuttgart, GERMANY, 02 September 2015 - 04 September 2015, http://dx.doi.org/10.1016/j.freeradbiomed.2015.07.103
    Conference Abstracts | 2015
    Associate Professor Shane Thomas
    Maiocchi S; Rees M; Thomas S, 2015, 'Regulation of Myeloperoxidase NO Oxidase Activity by Pharmacological Agents: Novel Biochemical Basis for NO Preservation by Phenolics and Nitroxides (Tempol)', in FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, Stuttgart, GERMANY, Vol. 86, pp. S29 - S29, presented at SFRR-E/SNFS Conference, Stuttgart, GERMANY, 02 September 2015 - 04 September 2015, http://dx.doi.org/10.1016/j.freeradbiomed.2015.07.104
    Conference Abstracts | 2015
    Associate Professor Shane Thomas
    Pasalic L; Abeynaike L; Glaros E; Thomas S; Hogg P; Chen V, 2015, 'NEUTROPHILS CONTRIBUTE TO THE GENERATION OF PROCOAGULANT PLATELETS BY A MYELOPEROXIDASE INDEPENDENT MECHANISM', in HAEMATOLOGICA, FERRATA STORTI FOUNDATION, Vienna, AUSTRIA, Vol. 100, pp. 144 - 144, presented at 20th Congress of European-Hematology-Association, Vienna, AUSTRIA, 11 June 2015 - 14 June 2015, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000361204901315&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2015
    Associate Professor Shane Thomas
    Pasalic L; Abeynaike L; Glaros E; Thomas S; Hogg P; Chen V, 2015, 'Neutrophils contribute to the generation of procoagulant platelets by a myeloperoxidase independent mechanism', in JOURNAL OF THROMBOSIS AND HAEMOSTASIS, WILEY-BLACKWELL, Vol. 13, pp. 408 - 408, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000356426903016&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2014
    Associate Professor Shane Thomas
    Hsu K; Hiroshima Y; Endoh Y; Thomas SR; Geczy CL, 2014, 'S100A8 is induced in macrophages by oxidants and modulates redox responses in inflammation', in CYTOKINE, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, Melbourne, AUSTRALIA, pp. 47 - 48, presented at 2nd Annual Meeting of the International-Cytokine-and-Interferon-Society (ICIS), Melbourne, AUSTRALIA, 26 October 2014 - 29 October 2014, http://dx.doi.org/10.1016/j.cyto.2014.07.090
    Conference Papers | 2014
    Associate Professor Shane Thomas
    Di Bartolo BA; Cartland SP; Prado-Lourenco L; Azahri NSM; Thai T; Yeung A; Thomas SR; Kavurma MM, 2014, 'TRAIL Promotes Angiogenesis and Ischemia-Induced Neovascularisation via NOX4, H202 and Nitric Oxide-Dependent Mechanisms', in CIRCULATION, LIPPINCOTT WILLIAMS & WILKINS, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209800304178&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2013
    Associate Professor Shane Thomas
    Azardaryany MK; Yeung AWS; Asshurst T; Thomas SR; King NJC, 2013, 'Modulation of immunity against genital Herpes simplex virus', in CYTOKINE, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, San Francisco, CA, pp. 245 - 245, presented at Annual Joint Conference of the International-Cytokine-Society and the International-Society-for-Interferon-and-Cytokine-Research, San Francisco, CA, 29 September 2013 - 03 October 2013, http://dx.doi.org/10.1016/j.cyto.2013.06.014
    Conference Papers | 2012
    Associate Professor Shane Thomas
    Thai T; Thomas SR, 2012, 'Myeloperoxidase and endothelial dysfunction', in Journal of Vascular Research, Karger, Basel, Switzerland, pp. 10 - 10, http://dx.doi.org/10.1159/000230992
    Conference Papers | 2010
    Associate Professor Shane Thomas
    Munoz-Erazo L; Natoli R; Yeung AWS; Provis J; Madigan MC; Thomas SR; King NJC, 2010, 'Microarray Analysis of Human Retinal Pigmented Epithelium Following Infection With West Nile Virus', in Investigative Ophthalmology and Visual Science, Association of Research Vision Ophthalmology Inc, Rockville, MD, USA, pp. 411, presented at ARVO, Fort Lauderdale, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000442387300395&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
    Conference Papers | 2009
    Associate Professor Shane Thomas
    Thai T; Dang L; Harwood D; Rees MD; Winterbourn C; Kettle AJ; Maghzal G; Keaney JF; Thomas SR, 2009, 'MYELOPEROXIDASE AND ENDOTHELIAL DYSFUNCTION', in PROCEEDINGS OF EUROSYS 2009, ACM, NEW YORK, pp. 10 - 10, presented at 14th Meeting of the Australian-and-New-Zealand-Microcirculation-Society, Queenstown, NEW ZEALAND, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000268340300011&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
    Conference Papers | 2009
    Associate Professor Shane Thomas
    Wang Y; Keaney JF; Stasch J; Wu BJ; Witting P; McKenzie GL; Ball HJ; Kapoor V; Thomas SR; Mellor A; Hunt NH; Liu H, 2009, 'KYNURENINE IS A NOVEL ENDOTHELIUM-DERIVED VASCULAR RELAXING FACTOR PRODUCED DURING INFLAMMATION', in Hypertension, 4th International Conference of cGMP Generators, Effectors and Therapeutic Implications, Regensburg, Germany, pp. 108 - 109, presented at 4th International Conference of cGMP Generators, Effectors and Therapeutic Implications, Regensburg, Germany, 19 June 2009 - 21 June 2009
    Conference Papers | 2008
    Associate Professor Shane Thomas
    Lim SY; Raftery M; Cai H; Thomas S; Hsu K; Geczy CL, 2008, 'S-nitrosylated S100A8-novel anti-inflammatory properties', in CYTOKINE, ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD, Montreal, CANADA, pp. 263 - 263, presented at 7th Joint Conference of the International-Cytokine-Society/International-Society-for-Interferon-and-Cytoklin-Research, Montreal, CANADA, 12 October 2008 - 16 October 2008, http://dx.doi.org/10.1016/j.cyto.2008.07.157
    Conference Papers | 2008
    Associate Professor Shane Thomas
    Wang Y; Liu H; Keaney JF; Stasch JP; Wu BJ; Witting PK; McKenzie G; Ball HJ; Kapoor V; Thomas SR; Mellor AL; Hunt NH; Stocker R, 2008, 'KYNURENINE IS A NOVEL ENDOTHELIUM-DERIVED VASCULAR RELAXING FACTOR PRODUCED DURING INFLAMMATION', in HYPERTENSION, LIPPINCOTT WILLIAMS & WILKINS, Melbourne, AUSTRALIA, pp. 1120 - 1120, presented at 30th Annual Scientific Meeting of the High-Blood-Pressure-Research-Council-of-Australia, Melbourne, AUSTRALIA, 03 December 2008 - 05 December 2008, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000266239300144&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2008
    Associate Professor Shane Thomas
    Lim SY; Raftery MJ; Cai H; Thomas SR; Geczy C, 2008, 'S-nitrosylated S100A8 suppresses mast cell activation: Novel anti-inflammatory properties', in Journal of Leukocyte Biology, Federation American Society Exp Biol, Bethesda, MD, USA, pp. A18 - A18, presented at DAMPS and Alarmins Symposium, Pittsburgh, Pennsylvania, 30 August 2008 - 02 September 2008, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000258091600049&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
    Conference Papers | 2000
    Associate Professor Shane Thomas
    Thomas SR; Stocker R, 2000, 'Antioxidant activities and redox regulation of interferon-gamma-induced tryptophan metabolism in human monocytes and macrophages', in Advances in Experimental Medicine and Biology, pp. 541 - 552
    Conference Papers | 1997
    Associate Professor Shane Thomas
    Thomas SR; Neuzil J; Stocker R, 1997, 'Inhibition of LDL oxidation by ubiquinol-10. A protective mechanism for coenzyme Q in atherogenesis?', in Molecular Aspects of Medicine, pp. 85 - 103, http://dx.doi.org/10.1016/S0098-2997(97)00031-9
    Conference Papers | 1995
    Associate Professor Shane Thomas
    Thomas SR; Neuzil J; Mohr D; Stocker R, 1995, 'Coantioxidants make α-tocopherol an efficient antioxidant for low- density lipoprotein', in American Journal of Clinical Nutrition
    Conference Papers | 1995
    Associate Professor Shane Thomas
    THOMAS SR; NEUZIL J; MOHR D; STOCKER R, 1995, 'COANTIOXIDANTS MAKE ALPHA-TOCOPHEROL AN EFFICIENT ANTIOXIDANT FOR LOW-DENSITY-LIPOPROTEIN', in AMERICAN JOURNAL OF CLINICAL NUTRITION, AMER SOC NUTRITION-ASN, pp. 1357 - 1364, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1995TK01900009&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2017
    Associate Professor Shane Thomas
    Kang YC; Glaros E; Thomas S; Qiao Q; Brownlee C; Pimanda J; Chandrakanthan V, 2017, 'Identification of Novel Embryonic Vascular Stem-like cells and their role in Coronary Vasculature development and repair', in MECHANISMS OF DEVELOPMENT, ELSEVIER SCIENCE BV, Natil Univ Singapore, Singapore, SINGAPORE, pp. S48 - S49, presented at 18th International Congress of Developmental Biology, Natil Univ Singapore, Singapore, SINGAPORE, 18 June 2017 - 22 June 2017, http://dx.doi.org/10.1016/j.mod.2017.04.088
    Conference Papers | 2017
    Associate Professor Shane Thomas
    Maiocchi S; Rees M; Morris J; Thomas S, 2017, 'Endothelial-targeted Nitroxides Inhibit MPO-mediated Endothelial Dysfunction', in FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, Baltimore, MD, pp. 207 - 207, presented at 24th Annual Meeting of the Society-for-Redox-Biology-and-Medicine (SfRBM), Baltimore, MD, 29 November 2017 - 02 December 2017, http://dx.doi.org/10.1016/j.freeradbiomed.2017.10.328
    Conference Papers | 2016
    Associate Professor Shane Thomas
    Dang L; Chan E; Thuan T; Glaros EN; Witting PK; Rees MD; Thomas SR, 2016, 'Endothelial-Transcytosed Myeloperoxidase Promotes Endothelial Dysfunction in an Oxidant Specific Manner: Novel Protective Actions of Thiocyanate and Nitrite', in FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, pp. S152 - S153, http://dx.doi.org/10.1016/j.freeradbiomed.2016.10.402
    Conference Papers | 2016
    Associate Professor Shane Thomas
    Lim YJ; Yeung AWS; Ma Y; Rees MD; Glaros EN; Hawkins CL; Jameson GNL; Witting PK; Terentis AC; Thomas SR, 2016, 'Indoleamine 2,3-Dioxygenase Is a Novel Mammalian Nitrite Reductase', in FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, pp. S61 - S61, http://dx.doi.org/10.1016/j.freeradbiomed.2016.10.161
    Conference Abstracts | 2015
    Associate Professor Shane Thomas
    Maiocchi S; Dang L; Morris J; Thomas S; Rees M, 2015, 'Inhibition of Myeloperoxidase-Mediated Endothelial Dysfunction by Nitroxides', in FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, Stuttgart, GERMANY, Vol. 86, pp. S28 - S29, presented at SFRR-E/SNFS Conference, Stuttgart, GERMANY, 02 September 2015 - 04 September 2015, http://dx.doi.org/10.1016/j.freeradbiomed.2015.07.103
    Conference Abstracts | 2015
    Associate Professor Shane Thomas
    Maiocchi S; Rees M; Thomas S, 2015, 'Regulation of Myeloperoxidase NO Oxidase Activity by Pharmacological Agents: Novel Biochemical Basis for NO Preservation by Phenolics and Nitroxides (Tempol)', in FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, Stuttgart, GERMANY, Vol. 86, pp. S29 - S29, presented at SFRR-E/SNFS Conference, Stuttgart, GERMANY, 02 September 2015 - 04 September 2015, http://dx.doi.org/10.1016/j.freeradbiomed.2015.07.104
    Conference Abstracts | 2015
    Associate Professor Shane Thomas
    Pasalic L; Abeynaike L; Glaros E; Thomas S; Hogg P; Chen V, 2015, 'NEUTROPHILS CONTRIBUTE TO THE GENERATION OF PROCOAGULANT PLATELETS BY A MYELOPEROXIDASE INDEPENDENT MECHANISM', in HAEMATOLOGICA, FERRATA STORTI FOUNDATION, Vienna, AUSTRIA, Vol. 100, pp. 144 - 144, presented at 20th Congress of European-Hematology-Association, Vienna, AUSTRIA, 11 June 2015 - 14 June 2015, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000361204901315&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2015
    Associate Professor Shane Thomas
    Pasalic L; Abeynaike L; Glaros E; Thomas S; Hogg P; Chen V, 2015, 'Neutrophils contribute to the generation of procoagulant platelets by a myeloperoxidase independent mechanism', in JOURNAL OF THROMBOSIS AND HAEMOSTASIS, WILEY-BLACKWELL, Vol. 13, pp. 408 - 408, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000356426903016&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2014
    Associate Professor Shane Thomas
    Hsu K; Hiroshima Y; Endoh Y; Thomas SR; Geczy CL, 2014, 'S100A8 is induced in macrophages by oxidants and modulates redox responses in inflammation', in CYTOKINE, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, Melbourne, AUSTRALIA, pp. 47 - 48, presented at 2nd Annual Meeting of the International-Cytokine-and-Interferon-Society (ICIS), Melbourne, AUSTRALIA, 26 October 2014 - 29 October 2014, http://dx.doi.org/10.1016/j.cyto.2014.07.090
    Conference Papers | 2014
    Associate Professor Shane Thomas
    Di Bartolo BA; Cartland SP; Prado-Lourenco L; Azahri NSM; Thai T; Yeung A; Thomas SR; Kavurma MM, 2014, 'TRAIL Promotes Angiogenesis and Ischemia-Induced Neovascularisation via NOX4, H202 and Nitric Oxide-Dependent Mechanisms', in CIRCULATION, LIPPINCOTT WILLIAMS & WILKINS, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209800304178&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2013
    Associate Professor Shane Thomas
    Pasalic L; Heather C; Thomas S; Chen VM, 2013, 'Cisplatin Fails To Stimulate Production Of Reactive Oxygen Species and Release Of Neutrophil Extracellular Traps By Human Neutrophils In Vitro', in BLOOD, AMER SOC HEMATOLOGY, New Orleans, LA, presented at 55th Annual Meeting of the American-Society-of-Hematology, New Orleans, LA, 07 December 2013 - 10 December 2013, http://dx.doi.org/10.1182/blood.V122.21.4714.4714
    Conference Papers | 2013
    Associate Professor Shane Thomas
    Azardaryany MK; Yeung AWS; Asshurst T; Thomas SR; King NJC, 2013, 'Modulation of immunity against genital Herpes simplex virus', in CYTOKINE, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, San Francisco, CA, pp. 245 - 245, presented at Annual Joint Conference of the International-Cytokine-Society and the International-Society-for-Interferon-and-Cytokine-Research, San Francisco, CA, 29 September 2013 - 03 October 2013, http://dx.doi.org/10.1016/j.cyto.2013.06.014
    Conference Papers | 2012
    Associate Professor Shane Thomas
    Thai T; Thomas SR, 2012, 'Myeloperoxidase and endothelial dysfunction', in Journal of Vascular Research, Karger, Basel, Switzerland, pp. 10 - 10, http://dx.doi.org/10.1159/000230992
    Conference Papers | 2010
    Associate Professor Shane Thomas
    Munoz-Erazo L; Natoli R; Yeung AWS; Provis J; Madigan MC; Thomas SR; King NJC, 2010, 'Microarray Analysis of Human Retinal Pigmented Epithelium Following Infection With West Nile Virus', in Investigative Ophthalmology and Visual Science, Association of Research Vision Ophthalmology Inc, Rockville, MD, USA, pp. 411, presented at ARVO, Fort Lauderdale, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000442387300395&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
    Conference Papers | 2009
    Associate Professor Shane Thomas
    Thai T; Dang L; Harwood D; Rees MD; Winterbourn C; Kettle AJ; Maghzal G; Keaney JF; Thomas SR, 2009, 'MYELOPEROXIDASE AND ENDOTHELIAL DYSFUNCTION', in PROCEEDINGS OF EUROSYS 2009, ACM, NEW YORK, pp. 10 - 10, presented at 14th Meeting of the Australian-and-New-Zealand-Microcirculation-Society, Queenstown, NEW ZEALAND, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000268340300011&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
    Conference Papers | 2009
    Associate Professor Shane Thomas
    Wang Y; Keaney JF; Stasch J; Wu BJ; Witting P; McKenzie GL; Ball HJ; Kapoor V; Thomas SR; Mellor A; Hunt NH; Liu H, 2009, 'KYNURENINE IS A NOVEL ENDOTHELIUM-DERIVED VASCULAR RELAXING FACTOR PRODUCED DURING INFLAMMATION', in Hypertension, 4th International Conference of cGMP Generators, Effectors and Therapeutic Implications, Regensburg, Germany, pp. 108 - 109, presented at 4th International Conference of cGMP Generators, Effectors and Therapeutic Implications, Regensburg, Germany, 19 June 2009 - 21 June 2009
    Conference Papers | 2008
    Associate Professor Shane Thomas
    Wang Y; Liu H; Keaney JF; Stasch JP; Wu BJ; Witting PK; McKenzie G; Ball HJ; Kapoor V; Thomas SR; Mellor AL; Hunt NH; Stocker R, 2008, 'KYNURENINE IS A NOVEL ENDOTHELIUM-DERIVED VASCULAR RELAXING FACTOR PRODUCED DURING INFLAMMATION', in HYPERTENSION, LIPPINCOTT WILLIAMS & WILKINS, Melbourne, AUSTRALIA, pp. 1120 - 1120, presented at 30th Annual Scientific Meeting of the High-Blood-Pressure-Research-Council-of-Australia, Melbourne, AUSTRALIA, 03 December 2008 - 05 December 2008, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000266239300144&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2008
    Associate Professor Shane Thomas
    Lim SY; Raftery M; Cai H; Thomas S; Hsu K; Geczy CL, 2008, 'S-nitrosylated S100A8-novel anti-inflammatory properties', in CYTOKINE, ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD, Montreal, CANADA, pp. 263 - 263, presented at 7th Joint Conference of the International-Cytokine-Society/International-Society-for-Interferon-and-Cytoklin-Research, Montreal, CANADA, 12 October 2008 - 16 October 2008, http://dx.doi.org/10.1016/j.cyto.2008.07.157
    Conference Papers | 2008
    Associate Professor Shane Thomas
    Lim SY; Raftery MJ; Cai H; Thomas SR; Geczy C, 2008, 'S-nitrosylated S100A8 suppresses mast cell activation: Novel anti-inflammatory properties', in Journal of Leukocyte Biology, Federation American Society Exp Biol, Bethesda, MD, USA, pp. A18 - A18, presented at DAMPS and Alarmins Symposium, Pittsburgh, Pennsylvania, 30 August 2008 - 02 September 2008, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000258091600049&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
    Conference Papers | 2000
    Associate Professor Shane Thomas
    Thomas SR; Stocker R, 2000, 'Antioxidant activities and redox regulation of interferon-gamma-induced tryptophan metabolism in human monocytes and macrophages', in Advances in Experimental Medicine and Biology, pp. 541 - 552
    Conference Papers | 1997
    Associate Professor Shane Thomas
    Thomas SR; Neuzil J; Stocker R, 1997, 'Inhibition of LDL oxidation by ubiquinol-10. A protective mechanism for coenzyme Q in atherogenesis?', in Molecular Aspects of Medicine, pp. 85 - 103, http://dx.doi.org/10.1016/S0098-2997(97)00031-9
    Conference Papers | 1995
    Associate Professor Shane Thomas
    THOMAS SR; NEUZIL J; MOHR D; STOCKER R, 1995, 'COANTIOXIDANTS MAKE ALPHA-TOCOPHEROL AN EFFICIENT ANTIOXIDANT FOR LOW-DENSITY-LIPOPROTEIN', in AMERICAN JOURNAL OF CLINICAL NUTRITION, AMER SOC NUTRITION-ASN, pp. 1357 - 1364, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1995TK01900009&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 1995
    Associate Professor Shane Thomas
    Thomas SR; Neuzil J; Mohr D; Stocker R, 1995, 'Coantioxidants make α-tocopherol an efficient antioxidant for low- density lipoprotein', in American Journal of Clinical Nutrition

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