Dr Sofia Omari

Conjoint Lecturer
Medicine & Health
School of Clinical Medicine

Dr Omari is an enthusiastic cancer researcher who has a passion to alleviate patients suffering through state-of-the-art research to find new targetable culprits. She also test novel therapeutic agents on blood cancer cells in vitro and in vivo through pre-clinical studies. She graduated from the University of Tasmania in 2014, studying the expression level of the Transient Receptor Potential Vanilloid 1 (TRPV1) in blood cancer cell lines and patients samples. She also studied the effect of Capsaicin, the active agent in hot chilli and the TRPV1 activator, on blood cancer cells. This work resulted in a few published journal articles.

During her postdoctoral studies, Dr. Omari studied acute lymphoid leukaemia, a rare blood cancer, in children. This work resulted in a few published journal articles on top tier journals. Currently, Dr. Omari is a postdoctoral scientist at AMR, Sydney, studying the effect of novel drugs on leukaemia cells in pre-clinical models.

  • Book Chapters | 2017
    Omari SA; Adams MJ; Geraghty DP, 2017, 'TRPV1 Channels in Immune Cells and Hematological Malignancies', in Geraghty DP; Rash LD (ed.), Advances in Pharmacology, ACADEMIC PRESS LTD-ELSEVIER SCIENCE LTD, pp. 173 - 198, http://dx.doi.org/10.1016/bs.apha.2017.01.002
  • Journal articles | 2023
    Moles E; Howard CB; Huda P; Karsa M; McCalmont H; Kimpton K; Duly A; Chen Y; Huang Y; Tursky ML; Ma D; Bustamante S; Pickford R; Connerty P; Omari S; Jolly CJ; Joshi S; Shen S; Pimanda JE; Dolnikov A; Cheung LC; Kotecha RS; Norris MD; Haber M; de Bock CE; Somers K; Lock RB; Thurecht KJ; Kavallaris M, 2023, 'Delivery of PEGylated liposomal doxorubicin by bispecific antibodies improves treatment in models of high-risk childhood leukemia', Science translational medicine, 15, pp. eabm1262 - eabm1262, http://dx.doi.org/10.1126/scitranslmed.abm1262
    Journal articles | 2022
    Omari SA; Geraghty DP; Khalafallah AA; Venkat P; Shegog YM; Ragg SJ; de Bock CE; Adams MJ, 2022, 'Optimized flow cytometric detection of transient receptor potential vanilloid-1 (TRPV1) in human hematological malignancies', Medical Oncology, 39, pp. 81, http://dx.doi.org/10.1007/s12032-022-01678-z
    Journal articles | 2022
    Page EC; Heatley SL; Eadie LN; McClure BJ; de Bock CE; Omari S; Yeung DT; Hughes TP; Thomas PQ; White DL, 2022, 'HMGN1 plays a significant role in CRLF2 driven Down Syndrome leukemia and provides a potential therapeutic target in this high-risk cohort', Oncogene, 41, pp. 797 - 808, http://dx.doi.org/10.1038/s41388-021-02126-4
    Journal articles | 2022
    2022, 'Optimized Flow Cytometric Detection of Transient Receptor Potential Vanilloid-1 (TRPV1) in Human Hematological Malignancies', Medical Oncology, 39, http://dx.doi.org/10.1007/s12032-022-01678-z
    Journal articles | 2021
    Boast B; Helian K; Andrews D; Li X; Cho V; Closa A; Sutton H; Reed J; Bergmann H; Roots C; Yabas M; Barthel N; Omari S; Young C; Miosge L; Eyras E; Nutt S; Hein N; Hannan K; Cockburn I; Goodnow C; Enders A, 2021, 'Dysregulation of PAX5 causes uncommitted B cell development and tumorigenesis in mice', , http://dx.doi.org/10.1101/2021.01.29.428877
    Journal articles | 2021
    Boast B; Miosge LA; Kuehn HS; Cho V; Athanasopoulos V; McNamara HA; Sontani Y; Mei Y; Howard D; Sutton HJ; Omari SA; Yu Z; Nasreen M; Daniel Andrews T; Cockburn IA; Goodnow CC; Rosenzweig SD; Enders A, 2021, 'A point mutation in IKAROS ZF1 causes a B cell deficiency in mice', Journal of Immunology, 206, pp. 1505 - 1514, http://dx.doi.org/10.4049/jimmunol.1901464
    Journal articles | 2021
    Van Thillo Q; De Bie J; Seneviratne JA; Demeyer S; Omari S; Balachandran A; Zhai V; Tam WL; Sweron B; Geerdens E; Gielen O; Provost S; Segers H; Boeckx N; Marshall GM; Cheung BB; Isobe K; Kato I; Takita J; Amos TG; Deveson IW; McCalmont H; Lock RB; Oxley EP; Garwood MM; Dickins RA; Uyttebroeck A; Carter DR; Cools J; de Bock CE, 2021, 'Oncogenic cooperation between TCF7-SPI1 and NRAS(G12D) requires β-catenin activity to drive T-cell acute lymphoblastic leukemia', Nature Communications, 12, pp. 4164, http://dx.doi.org/10.1038/s41467-021-24442-9
    Journal articles | 2016
    Omari SA; Adams MJ; Kunde DA; Geraghty DP, 2016, 'Capsaicin-Induced Death of Human Haematological Malignant Cell Lines is Independent of TRPV1 Activation', Pharmacology, 98, pp. 79 - 86, http://dx.doi.org/10.1159/000445437
    Journal articles | 2011
    Omari S; Khalafallah A; Ayesh M; Matalka I; Al-Hadithi R, 2011, 'High serum erythropoietin and ferritin levels in conjunction with anemia response in malignant lymphoma', Mediterranean Journal of Hematology and Infectious Diseases, 3, http://dx.doi.org/10.4084/MJHID.2011.018
  • Working Papers | 2021
    Omari SA; Geraghty DP; Khalafallah AA; Venkat P; Shegog YM; Ragg SJ; de Bock CE; Adams MJ, 2021, Optimized Flow Cytometric Detection of Transient Receptor Potential Vanilloid-1 (TRPV1) in Human Hematological Malignancies, medRxiv, http://dx.doi.org10.1101/2021.08.04.21261521, https://link.springer.com/article/10.1007/s12032-022-01678-z