Manager

Dr Sophie Pageon-Tamburic

Medicine & Health
Faculty Office

Sophie is interested in the strategies that immune cells, in particular T cells and Natural Killer cells, use in order to hunt down and efficiently destroy cancer cells. She was awarded a PhD in Cell and Molecular Biology on the topic of ligand recognition by Natural Killer (NK) cell receptors investigated using super-resolution microscopy (Imperial College London, 2012). She then relocated to Australia and joined the group of Prof. Katharina Gaus (UNSW) as a postdoctoral fellow, where I expanded my knowledge of advanced microscopy and immune cell biology (2013-2016).

Since January 2017, she has been working with Dr. Maté Biro, head of the Cell Motility and Mechanobiology Group within the EMBL Australia Node for Single Molecule Science (SMS, UNSW). She employs a combination of super-resolution microscopy, live cell imaging and flow cytometry techniques to decipher the molecular mechanisms underlying the migratory behaviour of immune cells and their decision to kill or not to kill a target cell they encounter. She is currently investigating the molecular cues that direct T cell migration in a tumour microenvironment.

Phone
52012
  • Journal articles | 2021
    Hywood JD; Rice G; Pageon SV; Read MN; Biro M, 2021, 'Detection and characterization of chemotaxis without cell tracking', Journal of the Royal Society Interface, 18, http://dx.doi.org/10.1098/rsif.2020.0879
    Journal articles | 2020
    Niño JLG; Pageon SV; Tay SS; Colakoglu F; Kempe D; Hywood J; Mazalo JK; Cremasco J; Govendir MA; Dagley LF; Hsu K; Rizzetto S; Zieba J; Rice G; Prior V; O’neill G; Williams RJ; Nisbet DR; Kramer B; Webb AI; Luciani F; Read MN; Biro M, 2020, 'Cytotoxic T cells swarm by homotypic chemokine signalling', eLife, 9, pp. 1 - 71, http://dx.doi.org/10.7554/eLife.56554
    Journal articles | 2018
    Pageon SV; Govendir MA; Kempe D; Biro M, 2018, 'Mechanoimmunology: Molecular-scale forces govern immune cell functions', Molecular Biology of the Cell, 29, pp. 1919 - 1926, http://dx.doi.org/10.1091/mbc.E18-02-0120
    Journal articles | 2017
    Ma Y; Pandzic E; Nicovich PR; Yamamoto Y; Kwiatek J; Pageon SV; Benda A; Rossy J; Gaus K, 2017, 'An intermolecular FRET sensor detects the dynamics of T cell receptor clustering', Nature Communications, 8, http://dx.doi.org/10.1038/ncomms15100
    Journal articles | 2016
    Kapoor-Kaushik N; Hinde E; Compeer EB; Yamamoto Y; Kraus F; Yang Z; Lou J; Pageon SV; Tabarin T; Gaus K; Rossy J, 2016, 'Distinct mechanisms regulate Lck spatial organization in activated T cells', Frontiers in Immunology, 7, http://dx.doi.org/10.3389/fimmu.2016.00083
    Journal articles | 2016
    Lou J; Rossy J; Deng Q; Pageon SV; Gaus K, 2016, 'New insights into how trafficking regulates T cell receptor signaling', Frontiers in Cell and Developmental Biology, 4, http://dx.doi.org/10.3389/fcell.2016.00077
    Journal articles | 2016
    Pageon SV; Nicovich PR; Mollazade M; Tabarin T; Gaus K, 2016, 'Clus-DoC: A combined cluster detection and colocalization analysis for single-molecule localization microscopy data', Molecular Biology of the Cell, 27, pp. 3627 - 3636, http://dx.doi.org/10.1091/mbc.E16-07-0478
    Journal articles | 2016
    Pageon SV; Tabarin T; Yamamoto Y; Ma Y; Bridgeman JS; Cohnen A; Benzing C; Gao Y; Crowther MD; Tungatt K; Dolton G; Sewell AK; Price DA; Acuto O; Parton RG; Gooding JJ; Rossy J; Rossjohn J; Gaus K, 2016, 'Functional role of T-cell receptor nanoclusters in signal initiation and antigen discrimination', Proceedings of the National Academy of Sciences of the United States of America, 113, pp. E5454 - E5463, http://dx.doi.org/10.1073/pnas.1607436113
    Journal articles | 2016
    Pageon SV; Tabarin T; Yamamoto Y; Ma Y; Nicovich PR; Bridgeman JS; Cohnen A; Benzing C; Gao Y; Crowther MD; Tungatt K; Dolton G; Sewell AK; Price DA; Acuto O; Parton RG; Gooding JJ; Rossy J; Rossjohn J; Gaus K, 2016, 'Erratum: Functional role of T-cell receptor nanoclusters in signal initiation and antigen discrimination (National Academy of Sciences (2016) 113:37 (E5454-E5463) DOI: 10.1073/pnas.1607436113)', Proceedings of the National Academy of Sciences of the United States of America, 113, pp. E6905, http://dx.doi.org/10.1073/pnas.1615763113
    Journal articles | 2014
    Tabarin T; Pageon SV; Bach CTT; Lu Y; O'Neill GM; Gooding JJ; Gaus K, 2014, 'Insights into adhesion biology using single-molecule localization microscopy', ChemPhysChem, 15, pp. 606 - 618, http://dx.doi.org/10.1002/cphc.201301041
    Journal articles | 2013
    Pageon SV; Aquino G; Lagrue K; Köhler K; Endres RG; Davis DM, 2013, 'Dynamics of natural killer cell receptor revealed by quantitative analysis of photoswitchable protein', Biophysical Journal, 105, pp. 1987 - 1996, http://dx.doi.org/10.1016/j.bpj.2013.09.025
    Journal articles | 2013
    Pageon SV; Cordoba SP; Owen DM; Rothery SM; Oszmiana A; Davis DM, 2013, 'Superresolution microscopy reveals nanometer-scale reorganization of inhibitory natural killer cell receptors upon activation of NKG2D', Science Signaling, 6, http://dx.doi.org/10.1126/scisignal.2003947
    Journal articles | 2013
    Rossy J; Pageon SV; Davis DM; Gaus K, 2013, 'Super-resolution microscopy of the immunological synapse', Current Opinion in Immunology, 25, pp. 307 - 312, http://dx.doi.org/10.1016/j.coi.2013.04.002
    Journal articles | 2012
    Pageon SV; Rudnickaf D; Davis DM, 2012, 'Illuminating the dynamics of signal integration in Natural Killer cells', Frontiers in Immunology, 3, http://dx.doi.org/10.3389/fimmu.2012.00308
    Journal articles | 2010
    Fadda L; Borhis G; Ahmed P; Cheent K; Pageon SV; Cazaly A; Stathopoulos S; Middleton D; Mulder A; Claas FHJ; Elliott T; Davis DM; Purbhoo MA; Khakoo SI, 2010, 'Peptide antagonism as a mechanism for NK cell activation', Proceedings of the National Academy of Sciences of the United States of America, 107, pp. 10160 - 10165, http://dx.doi.org/10.1073/pnas.0913745107
    Journal articles | 2010
    Purbhoo MA; Liu H; Oddos S; Owen DM; Neil MAA; Pageon SV; French PMW; Rudd CE; Davis DM, 2010, 'Dynamics of subsynaptic vesicles and surface microclusters at the immunological synapse', Science Signaling, 3, http://dx.doi.org/10.1126/scisignal.2000645
  • Conference Papers | 2016
    Pageon S; Tabarin T; Yamamoto Y; Gaus K, 2016, 'Nanoscale clustering of the T cell receptor regulates T cell signalling efficiency', in EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY-BLACKWELL, AUSTRALIA, Melbourne, pp. 1198 - 1198, presented at International Congress of Immunology (ICI), AUSTRALIA, Melbourne, 21 August 2016 - 26 August 2016, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000383610402809&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2015
    Nicovich PR; Tabarin T; Stiegler J; Pageon SV; Gaus K, 2015, 'Analysis of Nanoscale Protein Clustering with Quantitative Localization Microscopy', in BIOPHYSICAL JOURNAL, CELL PRESS, MD, Baltimore, pp. 475A - 475A, presented at 59th Annual Meeting of the Biophysical-Society, MD, Baltimore, 07 February 2015 - 11 February 2015, http://dx.doi.org/10.1016/j.bpj.2014.11.2598
    Conference Papers | 2010
    Purbhoo MA; Liu H; Oddos S; Owen DM; Neil MAA; Pageon SV; French PMW; Rudd CE; Davis DM, 2010, 'Dynamics of sub-synaptic vesicles and surface microclusters at the T cell immunological synapse', in IMMUNOLOGY, WILEY-BLACKWELL PUBLISHING, INC, ENGLAND, Liverpool, pp. 175 - 175, presented at Annual Congress of the British-Society-for-Immunology, ENGLAND, Liverpool, 06 December 2010 - 10 December 2010, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000284964100589&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1