Dr Stephen Palmer

Dr Stephen Palmer

Research & Enterprise
Knowledge Exchange Office

Dr Stephen Palmer is a Program Director at Novogen Ltd and Conjoint Senior Lecturer at UNSW Australia. He is a former member of the Cellular and Genetic Medicine Unit in the School of Medical Sciences with research interests in understanding the role of the gene GTF2IRD1 in brain development and human behaviour and its contribution towards the characteristic features of Williams-Beuren syndrome.

Stephen Palmer completed his PhD at University College London in 1992 and was awarded an MRC Postdoctoral Training Fellowship to work with Alan Ashworth at the Institute of Cancer Research. In 1997, he came to Australia on a Wellcome Trust International Travelling Fellowship, to work with Richard Harvey at the Victor Chang Cardiac Research Institute. After a brief spell back in the UK, Stephen returned to Australia in 2002, joining Edna Hardeman at the Children's Medical Research Institute and then on to UNSW Australia in 2009.

Skills include: drug development, cell biology, biochemistry, gene regulation, embryology, genetics and mouse models of disease

+61 2 9472 4108
  • Journal articles | 2021
    2021, 'Syntaxins 6 and 8 facilitate tau into secretory pathways', Biochemical Journal, 478, pp. 1471 - 1484, http://dx.doi.org/10.1042/BCJ20200664
    Journal articles | 2016
    Corley SM; Canales CP; Carmona-Mora P; Mendoza-Reinosa V; Beverdam A; Hardeman EC; Wilkins MR; Palmer SJ, 2016, 'RNA-Seq analysis of Gtf2ird1 knockout epidermal tissue provides potential insights into molecular mechanisms underpinning Williams-Beuren syndrome', BMC Genomics, 17, http://dx.doi.org/10.1186/s12864-016-2801-4
    Journal articles | 2015
    Canales CP; Wong AC Y; Gunning PW; Housley GD; Hardeman EC; Palmer SJ, 2015, 'The role of GTF2IRD1 in the auditory pathology of Williams-Beuren Syndrome', European Journal of Human Genetics, 23, pp. 774 - 780, http://dx.doi.org/10.1038/ejhg.2014.188
    Journal articles | 2015
    2015, 'The nuclear localization pattern and interaction partners of GTF2IRD1 demonstrate a role in chromatin regulation', Human Genetics, 134, pp. 1099 - 1115, http://dx.doi.org/10.1007/s00439-015-1591-0
    Journal articles | 2013
    Stehn JR; Haass NK; Bonello T; Desouza M; Kottyan G; Treutlein H; Zeng J; Nascimento PR B B; Sequeira VB; Butler TL; Allanson M; Fath T; Hill TA; McCluskey A; Schevzov G; Palmer SJ; Hardeman EC; Winlaw D; Reeve VE; Dixon I; Weninger W; Cripe TP; Gunning PW, 2013, 'A novel class of anticancer compounds targets the actin cytoskeleton in tumor cells', Cancer research, 73, pp. 5169 - 5182, http://dx.doi.org/10.1158/0008-5472.CAN-12-4501
    Journal articles | 2012
    Howard ML; Palmer SJ; Taylor KM; Arthurson GJ; Spitzer MW; Du X; Pang TY C; Renoir T; Hardeman EC; Hannan AJ, 2012, 'Mutation of Gtf2ird1 from the Williams-Beuren syndrome critical region results in facial dysplasia, motor dysfunction, and altered vocalisations.', Neurobiology of Disease, 45, pp. 913 - 922, http://dx.doi.org/10.1016/j.nbd.2011.12.010
    Journal articles | 2012
    Palmer SJ; Taylor KM; Santucci N; Widagdo J; Chan YK A; Yeo JL; Adams M; Gunning PW; Hardeman EC, 2012, 'GTF2IRD2 from the Williams-Beuren critical region encodes a mobile element-derived fusion protein that antagonizes the action of its related family members', Journal of Cell Science, 125, pp. 5040 - 5050, http://dx.doi.org/10.1242/​jcs.102798
    Journal articles | 2012
    Widagdo J; Taylor KM; Gunning PW; Hardeman EC; Palmer SJ, 2012, 'SUMOylation of GTF2IRD1 regulates protein partner interactions and ubiquitin-mediated degradation', PLoS ONE, 7, pp. e49283 pg 1 - e49283 pg 10, http://dx.doi.org/10.1371/journal.pone.0049283
    Journal articles | 2010
    Palmer SJ; Santucci N; Widagdo J; Bontempo SJ; Taylor KM; Tay ES E; Hook J; Lemckert F; Gunning PW; Hardeman EC, 2010, 'Negative autoregulation of GTF2IRD1 in Williams-Beuren syndrome via a novel DNA binding mechanism', The Journal of Biological Chemistry, 285, pp. 4715 - 4724, http://dx.doi.org/10.1074/jbc.M109.086660
    Journal articles | 2007
    Palmer SJ; Tay ES; Santucci N; Cuc Bach TT; Hook J; Lemckert FA; Jamieson RV; Gunning PW; Hardeman EC, 2007, 'Expression of Gtf2ird1, the Williams syndrome-associated gene during mouse development', Gene Expression Patterns, 7, pp. 396 - 404, http://dx.doi.org/10.1016/j.modgep.2006.11.008
    Journal articles | 2007
    Wilhelm D; Palmer S; Koopman P, 2007, 'Sex determination and gonadal development in mammals', Physiological Reviews, 87, pp. 1 - 28, http://dx.doi.org/10.1152/physrev.00009.2006
    Journal articles | 2006
    Issa LL; Palmer SJ; Guven KL; Santucci N; Hodgson VR M; Popovic K; Joya JE; Hardeman EC, 2006, 'MusTRD can regulate postnatal fiber-specific expression', Developmental Biology, 293, pp. 104 - 115, http://dx.doi.org/10.1016/j.ydbio.2006.01.019
    Journal articles | 2003
    Polly P; Haddadi LM; Issa LL; Subramaniam N; Palmer SJ; Tay ES E; Hardeman EC, 2003, 'hMusTRD1α1 Represses MEF2 Activation of the Troponin I Slow Enhancer', The Journal of Biological Chemistry, 278, pp. 36603 - 36610, http://dx.doi.org/10.1074/jbc.M212814200
    Journal articles | 2001
    Palmer S; Groves N; Schindeler A; Yeoh T; Biben C; Wang CC; Sparrow DB; Barnett L; Jenkins NA; Copeland NG; Koentgen F; Mohun T; Harvey RP, 2001, 'The small muscle-specific protein Csl modifies cell shape and promotes myocyte fusion in an IGF-1 dependent manner', Journal of Cell Biology, 153, pp. 985 - 997, http://dx.doi.org/10.1083/jcb.153.5.985
    Journal articles | 2001
    Perry J; Palmer S; Gabriel A; Ashworth A, 2001, 'A short pseudoautosomal region in laboratory mice.', Genome Research, 11, pp. 1826 - 1832, http://dx.doi.org/10.1101/gr.203001
    Journal articles | 2000
    Christoffels VM; Habets PE M H; Franco D; Campione M; De Jong F; Lamers WH; Bao ZZ; Palmer S; Biben C; Harvey RP; Moorman AF M, 2000, 'Chamber Formation and Morphogenesis in the Developing Mammalian Heart.', Developmental Biology, 223, pp. 266 - 278, http://dx.doi.org/10.1006/dbio.2000.9753
    Journal articles | 2000
    Christoffels VM; Habets PE M H; Franco D; Campione M; De Jong F; Lamers WH; Bao ZZ; Palmer S; Biben C; Harvey RP; Moorman AF M, 2000, 'Erratum: Chamber formation and morphogenesis in the developing mammalian heart (Developmental Biology (2000) 223:2 (266-278))', Developmental Biology, 225, pp. 266, http://dx.doi.org/10.1006/dbio.2000.9859
    Journal articles | 1999
    Biben C; Palmer SJ; Kesteven A; Schindeler A; Groves N; McDonald L; Feneley M; Harvey RP, 1999, 'Role of homeodomain factor Nkx2-5 in cardiac development and disease', DEVELOPMENTAL BIOLOGY, 210, pp. 205 - 205, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000080918000154&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 1998
    Burgoyne PS; Mahadevaiah SK; Perry J; Palmer SJ; Ashworth A, 1998, 'The Y* rearrangement in mice: New insights into a perplexing PAR', Cytogenetics and Cell Genetics, 80, pp. 37 - 40, http://dx.doi.org/10.1159/000014954
    Journal articles | 1998
    Korobova O; Lane PW; Perry J; Palmer S; Ashworth A; Davisson MT; Arnheim N, 1998, 'Patchy fur, a mouse coat mutation associated with X-Y nondisjunction, maps to the pseudoautosomal boundary region.', Genomics, 54, pp. 556 - 559, http://dx.doi.org/10.1006/geno.1998.5528
    Journal articles | 1998
    Perry J; Feather S; Smith A; Palmer S; Ashworth A, 1998, 'The human FXY gene is located within Xp22.3: Implications for evolution of the mammalian X chromosome', Human Molecular Genetics, 7, pp. 299 - 305, http://dx.doi.org/10.1093/hmg/7.2.299
    Journal articles | 1998
    1998, 'The Y* rearrangement in mice: new insights into a perplexing pseudoautosomal region', Genetical Research, 72, pp. 59 - 72, http://dx.doi.org/10.1017/s0016672398393301
    Journal articles | 1997
    Palmer S; Perry J; Kipling D; Ashworth A, 1997, 'A gene spans the pseudoautosomal boundary in mice', Proceedings of the National Academy of Sciences of the United States of America, 94, pp. 12030 - 12035, http://dx.doi.org/10.1073/pnas.94.22.12030
    Journal articles | 1996
    Kipling D; Wilson HE; Thomson EJ; Lee M; Perry J; Palmer S; Ashworth A; Cooke HJ, 1996, 'Structural variation of the pseudoautosomal region between and within inbred mouse strains', Proceedings of the National Academy of Sciences of the United States of America, 93, pp. 171 - 175, http://dx.doi.org/10.1073/pnas.93.1.171
    Journal articles | 1995
    Palmer S; Perry J; Ashworth A, 1995, 'A contravention of Ohno’s law in mice', Nature Genetics, 10, pp. 472 - 476, http://dx.doi.org/10.1038/ng0895-472
    Journal articles | 1992
    Burgoyne PS; Mahadevaiah SK; Sutcliffe MJ; Palmer SJ, 1992, 'Fertility in mice requires X-Y pairing and a Y-chromosomal "Spermiogenesis" gene mapping to the long arm', Cell, 71, pp. 391 - 398, http://dx.doi.org/10.1016/0092-8674(92)90509-B
    Journal articles | 1991
    Palmer SJ; Burgoyne PS, 1991, 'In situ analysis of fetal, prepubertal and adult XX⇆XY chimaeric mouse testes: Sertoli cells are predominantly, but not exclusively, XY', Development, 112, pp. 265 - 268
    Journal articles | 1991
    Palmer SJ; Burgoyne PS, 1991, 'The Mus musculus domesticus Tdy allele acts later than the Mus musculus musculus Tdy allele: A basis for XY sex-reversal in C57BL/6-Y(POS) mice', Development, 113, pp. 709 - 714
    Journal articles | 1991
    Palmer SJ; Burgoyne PS, 1991, 'XY follicle cells in the ovaries of XO/XY and XO/XY/XYY mosaic mice', Development, 111, pp. 1017 - 1019
    Journal articles | 1990
    Palmer SJ; Mahadevaiah SK; Burgoyne PS, 1990, 'XYY spermatogenesis in XO/XY/XYY mosaic mice', Cytogenetics and Cell Genetics, 54, pp. 29 - 34, http://dx.doi.org/10.1159/000132949
    Journal articles | 1990
    Woolf AS; Palmer SJ; Snow ML; Fine LG, 1990, 'Creation of a functioning chimeric mammalian kidney', Kidney International, 38, pp. 991 - 997, http://dx.doi.org/10.1038/ki.1990.303
  • Conference Abstracts | 2012
    Segueira VB; Stehn JR; Haass N; Bonello T; Guven K; Desouza M; Schevzov G; Kottyan G; McCluskey A; Bischof L; Palmer S; Hardeman EC; Allanson M; Reeve V; Weninger W; Cripe TP; Gunning P, 2012, 'Improving the specificity of drugs which target the actin cytoskeleton for cancer therapy', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, Vol. 72, http://dx.doi.org/10.1158/1538-7445.AM2012-5230
    Conference Papers | 2012
    Stehn JR; Haass NK; Bonello T; Desouza M; Kottyan G; Treutlein H; Zeng J; Nascimento PR; Butler T; Allanson M; Fath T; Hill TA; McCluskey A; Schevzov G; Palmer S; Hardeman EC; Winlaw D; Reeve VE; Dixon I; Weninger W; Cripe TP; Gunning P, 2012, 'Developing chemotherapeutics which selectively disable the actin cytoskeleton of tumor cells', in EXPERIMENTAL DERMATOLOGY, WILEY-BLACKWELL, GERMANY, Marburg, pp. e43 - e43, presented at 39th Annual Meeting of the Arbeitsgemeinschaft-Dermatologische-Forschung (ADF), GERMANY, Marburg, 01 March 2012 - 03 March 2012, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000300931700252&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2011
    2011, 'Abstract A178: Developing chemotherapeutics which selectively disable the actin cytoskeleton of tumor cells.', in Molecular Cancer Therapeutics, American Association for Cancer Research (AACR), pp. A178 - A178, presented at Abstracts: AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics--Nov 12-16, 2011; San Francisco, CA, http://dx.doi.org/10.1158/1535-7163.targ-11-a178
    Conference Papers | 2010
    Stehn J; Schevzov G; Bonello T; McCluskey A; Haass N; Palmer S; Hardeman E; Allanson M; Reeve V; Gunning P, 2010, 'Tropomyosin Tm5NM1: A novel target for cancer therapy', in EJC SUPPLEMENTS, PERGAMON-ELSEVIER SCIENCE LTD, GERMANY, Berlin, pp. 107 - 107, presented at 22nd EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, GERMANY, Berlin, 16 November 2010 - 19 November 2010, http://dx.doi.org/10.1016/S1359-6349(10)72041-3
    Conference Papers | 1997
    Biben C; Palmer S; Elliott DA; Harvey RP, 1997, 'Homebox genes and heart development', in Cold Spring Harbor Symposia on Quantitative Biology, pp. 395 - 403, http://dx.doi.org/10.1101/sqb.1997.062.01.047
    Conference Papers | 1992
    BURGOYNE PS; PALMER SJ, 1992, 'CELLULAR BASIS OF SEX DETERMINATION AND SEX REVERSAL IN MAMMALS', in Hillier SG (ed.), GONADAL DEVELOPMENT AND FUNCTION, RAVEN PRESS, SCOTLAND, PEEBLES, pp. 17 - 29, presented at 9TH WORKSHOP ON THE DEVELOPMENT AND FUNCTION OF REPRODUCTIVE ORGANS, SCOTLAND, PEEBLES, 25 May 1992 - 27 May 1992, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1992BY12C00003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1