Dr Stuart   Hamilton
Lecturer

Dr Stuart Hamilton

BSc, PhD 

medicine-health
Discipline of Paediatrics

I am a NHMRC Early Career Research Fellow and Postdoctoral Research Scientist at the Virology Research Laboratory, SEALS Microbiology, Prince of Wales Hospital and School of Women’s and Children’s Health, University of New South Wales. I completed my Bachelor of Science degree at UNSW with a double major in Molecular Biology/Medical Microbiology and Immunology. I received 1st class honours for my research and was the recipient of the inaugural Stillbirth Foundation Australia PhD Scholarship and Australian Postgraduate Award. My PhD project investigated human cytomegalovirus (CMV) immunomodulation within the placenta during pregnancy and the implications for adverse pregnancy outcomes, in addition to the development of novel antiviral siRNA molecules as a potential therapeutic. During my PhD I accumulated extensive national and international experience and expertise in the fields of virology, immunology, placentology, molecular biology and diagnostics at various leading institutions including the Institute for Clinical and Molecular Biology, University of Nuremberg-Erlangen, Germany.

Research Interests
My research interests include determining the mechanisms by which CMV placental infection can lead to adverse pregnancy outcomes and investigating antiviral compounds for use during pregnancy. 
– Examining the adverse effects CMV infection has on placental development/function and pregnancy outcomes
– Understanding transmission modes of intrauterine CMV infection
– Developing novel ex vivo placental explant histoculture systems for pathogenesis and therapeutic studies
– Investigating CMV antiviral safety and efficacy profiles in human placental models
– Discovering novel biomarkers for adverse pregnancy outcomes

Phone
0293829096
Location
Virology Research Laboratory, Level 3, Clinical Sciences Building, Prince of Wales Hospital

Publications

  • Book Chapters | 2014
    Dr Stuart Hamilton
    Graf L; Webel R; Wagner S; Hamilton S; Rawlinson W; Stitch H; Marschall M, 2014, 'The Cyclin-dependent kinase ortholog pUL97 of human cytomegalovirus interacts with cyclins', in Recent CMV Research
  • Journal articles | 2021
    Dr Stuart Hamilton
    Hamilton ST; Hahn F; Sonntag E; Marschall M; Rawlinson WD, 2021, 'A placental specific miRNA miR-517a-3p exerts anti-human cytomegalovirus activity', Placenta, vol. 112, pp. 62 - 65, http://dx.doi.org/10.1016/j.placenta.2021.06.013
    Journal articles | 2021
    Dr Stuart Hamilton
    Hamilton ST; Marschall M; Rawlinson WD, 2021, 'Investigational antiviral therapy models for the prevention and treatment of congenital cytomegalovirus infection during pregnancy', Antimicrobial Agents and Chemotherapy, vol. 65, http://dx.doi.org/10.1128/AAC.01627-20
    Journal articles | 2021
    Dr Stuart Hamilton
    Singh K; Hamilton ST; Shand AW; Hannan NJ; Rawlinson WD, 2021, 'Receptors in host pathogen interactions between human cytomegalovirus and the placenta during congenital infection', Reviews in Medical Virology, http://dx.doi.org/10.1002/rmv.2233
    Journal articles | 2020
    Dr Stuart Hamilton
    Häge S; Horsch D; Stilp AC; Kicuntod J; Müller R; Hamilton ST; Egilmezer E; Rawlinson WD; Stamminger T; Sonntag E; Marschall M, 2020, 'A quantitative nuclear egress assay to investigate the nucleocytoplasmic capsid release of human cytomegalovirus', Journal of Virological Methods, vol. 283, http://dx.doi.org/10.1016/j.jviromet.2020.113909
    Journal articles | 2020
    Dr Stuart Hamilton
    Naing Z; Hamilton ST; van Zuylen WJ; Scott GM; Rawlinson WD, 2020, 'Differential Expression of PDGF Receptor-α in Human Placental Trophoblasts Leads to Different Entry Pathways by Human Cytomegalovirus Strains', Scientific Reports, vol. 10, http://dx.doi.org/10.1038/s41598-020-57471-3
    Journal articles | 2020
    Dr Stuart Hamilton
    Bartlett AW; Hamilton ST; Shand AW; Rawlinson WD, 2020, 'Fetal therapies for cytomegalovirus: What we tell prospective parents', Prenatal Diagnosis, vol. 40, pp. 1681 - 1692, http://dx.doi.org/10.1002/pd.5692
    Journal articles | 2020
    Dr Stuart Hamilton
    Helbig KJ; Bull RA; Ambrose R; Beard MR; Blanchard H; Böcking T; Chua B; Colmant AMG; Crosse KM; Purcell DFJ; Fraser J; Hayward JA; Hamilton ST; Husain M; MacDiarmid R; MacKenzie JM; Moseley GW; Nguyen THO; Quiñones-Mateu ME; Robinson K; Rodrigo C; Rodriguez-Andres J; Rudd PA; Werno A; White P; Young P; Speck P; Hibma M; Drummer HE; Tachedjian G, 2020, 'Tenth scientific biennial meeting of the australasian virology society - AVS10 2019', Viruses, vol. 12, http://dx.doi.org/10.3390/v12060621
    Journal articles | 2020
    Dr Stuart Hamilton
    Singh K; Palasanthiran P; Hamilton ST; Rawlinson WD, 2020, 'Cotton wool balls are an effective urine collection tool for CMV PCR for diagnosing congenital cytomegalovirus infection', Pathology, vol. 52, pp. 504 - 506, http://dx.doi.org/10.1016/j.pathol.2020.03.009
    Journal articles | 2019
    Dr Stuart Hamilton
    Wong DD; Van Zuylen WJ; Hamilton ST; Steingruber M; Sonntag E; Marschall M; Rawlinson WD, 2019, 'Patient-derived cytomegaloviruses with different ganciclovir sensitivities from UL97 mutation retain their replication efficiency and some kinase activity in vitro', Antimicrobial Agents and Chemotherapy, vol. 63, http://dx.doi.org/10.1128/AAC.02425-18
    Journal articles | 2018
    Dr Stuart Hamilton
    Hamilton ST; Hutterer C; Egilmezer E; Steingruber M; Milbradt J; Marschall M; Rawlinson WD, 2018, 'Human cytomegalovirus utilises cellular dual-specificity tyrosine phosphorylation-regulated kinases during placental replication', Placenta, vol. 72-73, pp. 10 - 19, http://dx.doi.org/10.1016/j.placenta.2018.10.002
    Journal articles | 2018
    Dr Stuart Hamilton
    Hahn F; Hutterer C; Henry C; Hamilton ST; Strojan H; Kraut A; Schulte U; Schütz M; Kohrt S; Wangen C; Pfizer J; Couté Y; Rawlinson WD; Strobl S; Marschall M, 2018, 'Novel cytomegalovirus-inhibitory compounds of the class pyrrolopyridines show a complex pattern of target binding that suggests an unusual mechanism of antiviral activity', Antiviral Research, vol. 159, pp. 84 - 94, http://dx.doi.org/10.1016/j.antiviral.2018.09.012
    Journal articles | 2017
    Dr Stuart Hamilton
    Ornelas AMM; Pezzuto P; Silveira PP; Melo FO; Ferreira TA; Oliveira-Szejnfeld PS; Leal JI; Amorim MMR; Hamilton S; Rawlinson WD; Cardoso CC; Nixon DF; Tanuri A; Melo AS; Aguiar RS, 2017, 'Immune activation in amniotic fluid from Zika virus–associated microcephaly', Annals of Neurology, vol. 81, pp. 152 - 156, http://dx.doi.org/10.1002/ana.24839
    Journal articles | 2017
    Dr Stuart Hamilton
    Hutterer C; Milbradt J; Hamilton S; Zaja M; Leban J; Henry C; Vitt D; Steingruber M; Sonntag E; Zeitträger I; Bahsi H; Stamminger T; Rawlinson W; Strobl S; Marschall M, 2017, 'Inhibitors of dual-specificity tyrosine phosphorylation-regulated kinases (DYRK) exert a strong anti-herpesviral activity', Antiviral Research, vol. 143, pp. 113 - 121, http://dx.doi.org/10.1016/j.antiviral.2017.04.003
    Journal articles | 2017
    Dr Stuart Hamilton
    Rawlinson WD; Boppana SB; Fowler KB; Kimberlin DW; Lazzarotto T; Alain S; Daly K; Doutré S; Gibson L; Giles ML; Greenlee J; Hamilton ST; Harrison GJ; Hui L; Jones CA; Palasanthiran P; Schleiss MR; Shand AW; van Zuylen WJ, 2017, 'Congenital cytomegalovirus infection in pregnancy and the neonate: consensus recommendations for prevention, diagnosis, and therapy', The Lancet Infectious Diseases, vol. 17, pp. e177 - e188, http://dx.doi.org/10.1016/S1473-3099(17)30143-3
    Journal articles | 2017
    Dr Stuart Hamilton
    van Zuylen WJ; Zheng QY; Hamilton ST; Egilmezer EE; Craig ME; Gralton J; Rawlinson WD, 2017, 'Prevalence of cytomegalovirus carriage among childcare staff', Journal of Paediatrics and Child Health, vol. 53, pp. 724, http://dx.doi.org/10.1111/jpc.13600
    Journal articles | 2016
    Dr Stuart Hamilton
    Rawlinson WD; Hamilton ST; Van Zuylen WJ, 2016, 'Update on treatment of cytomegalovirus infection in pregnancy and of the newborn with congenital cytomegalovirus', Current Opinion in Infectious Diseases, vol. 29, pp. 615 - 624, http://dx.doi.org/10.1097/QCO.0000000000000317
    Journal articles | 2016
    Dr Stuart Hamilton
    Hutterer C; Hamilton S; Steingruber M; Zeitträger I; Bahsi H; Thuma N; Naing Z; Örfi Z; Örfi L; Socher E; Sticht H; Rawlinson W; Chou S; Haupt VJ; Marschall M, 2016, 'The chemical class of quinazoline compounds provides a core structure for the design of anticytomegaloviral kinase inhibitors', Antiviral Research, vol. 134, pp. 130 - 143, http://dx.doi.org/10.1016/j.antiviral.2016.08.005
    Journal articles | 2016
    Dr Stuart Hamilton
    Sonntag E; Hamilton ST; Bahsi H; Wagner S; Jonjic S; Rawlinson WD; Marschall M; Milbradt J, 2016, 'Cytomegalovirus pUL50 is the multi-interacting determinant of the core nuclear egress complex (NEC) that recruits cellular accessory NEC components', Journal of General Virology, vol. 97, pp. 1676 - 1685, http://dx.doi.org/10.1099/jgv.0.000495
    Journal articles | 2016
    Dr Stuart Hamilton
    Graf L; Feichtinger S; Naing Z; Hutterer C; Milbradt J; Webel R; Wagner S; Scott GM; Hamilton ST; Rawlinson WD; Stamminger T; Thomas M; Marschall M, 2016, 'New insight into the phosphorylation-regulated intranuclear localization of human cytomegalovirus pUL69 mediated by cyclin-dependent kinases (CDKs) and viral CDK orthologue pUL97', Journal of General Virology, vol. 97, pp. 144 - 151, http://dx.doi.org/10.1099/jgv.0.000337
    Journal articles | 2016
    Dr Stuart Hamilton
    Naing ZW; Scott GM; Shand A; Hamilton ST; Van Zuylen WJ; Basha J; Hall B; Craig ME; Rawlinson WD, 2016, 'Congenital cytomegalovirus infection in pregnancy: A review of prevalence, clinical features, diagnosis and prevention', Australian and New Zealand Journal of Obstetrics and Gynaecology, vol. 56, pp. 9 - 18, http://dx.doi.org/10.1111/ajo.12408
    Journal articles | 2016
    Dr Stuart Hamilton
    Sonntag E; Hamilton ST; Bahsi H; Wagner S; Jonjic S; Rawlinson WD; Marschall M; Milbradt J, 2016, 'Erratum to Cytomegalovirus pUL50 is the multi-interacting determinant of the core nuclear egress complex (NEC) that recruits cellular accessory NEC components.', J Gen Virol, vol. 97, pp. 2461, http://dx.doi.org/10.1099/jgv.0.000599
    Journal articles | 2015
    Dr Stuart Hamilton
    Hamilton ST; Hutterer C; Marschall M, 2015, 'Therapeutics to prevent congenital cytomegalovirus during pregnancy: what is available now and in the future?', MICROBIOLOGY AUSTRALIA, vol. 36, pp. 156 - 161, http://dx.doi.org/10.1071/MA15057
    Journal articles | 2015
    Dr Stuart Hamilton
    Naing ZW; Scott GM; Shand A; Hamilton ST; van Zuijlen WJ; Basha J; Hall B; Craig ME; Rawlinson WD, 2015, 'Congenital cytomegalovirus infection in pregnancy: a review of prevalence, clinical features, diagnosis and prevention', Aust N Z J Obstet Gynaecol., http://dx.doi.org/10.1111/ajo.12408
    Journal articles | 2015
    Dr Stuart Hamilton
    Naing Z; Webel R; Hamilton S; Schmeiser C; Scott G; Marschall M; Rawlinson WD, 2015, 'Stimulatory effects of human cytomegalovirus tegument protein pp71 lead to increased expression of CCL2 (monocyte chemotactic protein-1) during infection', Journal of General Virology, vol. 96, pp. 1855 - 1862, http://dx.doi.org/10.1099/vir.0.000101
    Journal articles | 2015
    Dr Stuart Hamilton
    Rogers N, 2015, 'A dormant danger: New therapies target a ubiquitous pathogen known as cytomegalovirus.', Nat Med, vol. 21, pp. 1104 - 1105, http://dx.doi.org/10.1038/nm1015-1104
    Journal articles | 2014
    Dr Stuart Hamilton
    Milbradt J; Kraut A; Hutterer C; Sonntag E; Schmeiser C; Ferro M; Wagner S; Lenac T; Claus C; Pinkert S; Hamilton ST; Rawlinson WD; Sticht H; Couté Y; Marschall M, 2014, 'Proteomic analysis of the multimeric nuclear egress complex of human cytomegalovirus', Molecular and Cellular Proteomics, vol. 13, pp. 2132 - 2146, http://dx.doi.org/10.1074/mcp.M113.035782
    Journal articles | 2014
    Dr Stuart Hamilton
    Hamilton ST; Milbradt J; Marschall M; Rawlinson WD, 2014, 'Human cytomegalovirus replication is strictly inhibited by siRNAs targeting UL54, UL97 or UL122/123 gene transcripts', PLoS ONE, vol. 9, http://dx.doi.org/10.1371/journal.pone.0097231
    Journal articles | 2014
    Dr Stuart Hamilton
    van Zuylen WJ; Hamilton ST; Naing Z; Hall B; Shand A; Rawlinson W, 2014, 'Congenital Cytomegalovirus Infection: Epidemiology, Diagnosis and Prevention', Obstetric Medicine: The Medicine of Pregnancy, vol. 7, pp. 140 - 146, http://dx.doi.org/10.1177/1753495X14552719
    Journal articles | 2014
    Dr Stuart Hamilton
    Hamilton ST; van Zuylen W; Shand A; Naing Z; Hall B; Craig ME; Rawlinson W, 2014, 'Prevention of Congenital Cytomegalovirus by Maternal and Neonatal Treatments: A Systematic Review', Medical Virology, vol. 24, pp. 420 - 433, http://dx.doi.org/10.1002/rmv.1814
    Journal articles | 2013
    Dr Stuart Hamilton
    Hamilton ST; Scott GM; Naing Z; Rawlinson WD, 2013, 'Human cytomegalovirus directly modulates expression of chemokine CCL2 (MCP-1) during viral replication', Journal of General Virology, vol. 94, pp. 2495 - 2503, http://dx.doi.org/10.1099/vir.0.052878-0
    Journal articles | 2013
    Dr Stuart Hamilton
    Graf L; Webel R; Wagner S; Hamilton ST; Rawlinson WD; Sticht H; Marschall M, 2013, 'The cyclin-dependent kinase ortholog pUL97 of human cytomegalovirus interacts with cyclins', Viruses, vol. 5, pp. 3213 - 3230, http://dx.doi.org/10.3390/v5123213
    Journal articles | 2012
    Dr Stuart Hamilton
    Hamilton ST; Scott GMS; Naing ZW; Iwasenko JM; Hall B; Graf NS; Arbuckle SM; Craig ME; Rawlinson WD, 2012, 'Human cytomegalovirus induces cytokine changes in the placenta with implications for adverse pregnancy outcomes', PLoS ONE, vol. 7, pp. e52899, http://dx.doi.org/10.1371/journal.pone.0052899
  • Conference Abstracts | 2019
    Dr Stuart Hamilton
    Hamilton S, 2019, 'Therapeutics for the prevention of congenital cytomegalovirus infection and disease during pregnancy.', in The 10th Biennial Meeting of the Australasian Virology Society Handbook, presented at 10th Australasian Virology Society (AVS10) Meeting. Queenstown, New Zealand
    Conference Abstracts | 2018
    Dr Stuart Hamilton
    Hamilton S, 2018, 'Human cytomegalovirus utilises cellular dual-specificity tyrosine phosphorylation-regulated kinases during placental replication', in 43rd Annual International Herpes Virus Workshop Handbook, presented at 43rd Annual International Herpes Virus Workshop. Vancouver, Canada
    Conference Abstracts | 2017
    Dr Stuart Hamilton
    Hamilton S, 2017, 'Novel Antivirals for the Prevention and Treatment of Congenital CMV', in Conference Handbook, Amsterdam, Netherlands, presented at The 16th International CMV/Betaherpesvirus Workshop and 6th International Congenital CMV Conference Combined Meeting. Amsterdam, Netherlands, Amsterdam, Netherlands, 30 April 2017 - 04 May 2017
    Conference Abstracts | 2012
    Dr Stuart Hamilton
    Hamilton S, 2012, 'Small Interfering RNA (siRNA) Molecules as a Novel Therapeutic Strategy in the Prevention of Congenital CMV', in Conference Handbook, San Francisco, USA, presented at The 14th International CMV/Betaherpesvirus Workshop and 4th International Congenital CMV Conference Combined Meeting., San Francisco, USA, 29 October 2012 - 02 November 2012
    Conference Abstracts | 2011
    Dr Stuart Hamilton
    Hamilton S, 2011, 'CMV-induced Cytokine Changes within the Placenta and the Implications for Pregnancy Outcome.', in Conference Handbook, Nuremberg, Germany, presented at The 13th International CMV/Betaherpesvirus Workshop., Nuremberg, Germany, 14 May 2011 - 17 May 2011
    Conference Papers | 2010
    Dr Stuart Hamilton
    Hamilton S, 2010, 'The Role of Human Cytomegalovirus in Stillbirth and Other Adverse Outcomes of Pregnancy', Sydney, presented at ISA and ISPID Joint Conference, Sydney, 08 October 2010 - 10 October 2010

Awards

2020    UNSW 3Rs Grant Scheme
2019    Best New Investigator Paper - International Federation of Placenta Associations and Placenta Journal 
2018    Thrasher Research Fund Early Career Award
2017    NHMRC Peter Doherty Biomedical Early Career Fellowship
2015    Australasian Virology Society Early Career Researcher Session Chair Award
2012    Postgraduate Research Student Support Award UNSW
2010    The Inaugural Stillbirth Foundation Australia PhD Scholarship
2010    Australian Postgraduate Award
2009    Australian Society of Microbiology Honours Student Prize
2009    Australian Virology Group Student Presentation Award
2009    Coast Association Tow Awards Poster Prize

Grants

Media