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Ms Tharusha Jayasena

Postdoctoral Fellow
Medicine & Health
Centre for Healthy Brain Ageing

Meet Our Researcher
Click here to read Dr Tharusha Jayasena's ‘Meet Our Researcher’ interview
Phone
51995
E-mail
t.jayasena@unsw.edu.au
  • Book Chapters | 2023
    Braidy N; Poljak A; Jayasena T; Adams S; Sachdev P, 2023, 'Glutamate in the Pathogenesis of Gliomas', in Handbook of Neurotoxicity, Second Edition, pp. 2029 - 2041, http://dx.doi.org/10.1007/978-3-031-15080-7_149
    Book Chapters | 2023
    Braidy N; Poljak A; Jayasena T; Guillemin GJ; Sachdev P, 2023, 'Ionotropic Receptors in the Central Nervous System and Neurodegenerative Disease', in Handbook of Neurotoxicity, Second Edition, pp. 747 - 768, http://dx.doi.org/10.1007/978-3-031-15080-7_126
    Book Chapters | 2022
    Braidy N; Poljak A; Jayasena T; Adams S; Sachdev P, 2022, 'Glutamate in the Pathogenesis of Gliomas', in Handbook of Neurotoxicity, Springer International Publishing, pp. 1 - 13, http://dx.doi.org/10.1007/978-3-030-71519-9_149-1
    Book Chapters | 2022
    Braidy N; Poljak A; Jayasena T; Guillemin GJ; Sachdev P, 2022, 'Ionotropic Receptors in the Central Nervous System and Neurodegenerative Disease', in Handbook of Neurotoxicity, Springer International Publishing, pp. 1 - 22, http://dx.doi.org/10.1007/978-3-030-71519-9_126-1
    Book Chapters | 2022
    Jayasena T; Bustamante S; Poljak A; Sachdev P, 2022, 'Assay of Fatty Acids and Their Role in the Prevention and Treatment of COVID-19', in Multiplex Biomarker Techniques: Methods and Applications for COVID-19 Disease Diagnosis and Risk Stratification, Springer US, New York, NY, USA, pp. 213 - 234, http://dx.doi.org/10.1007/978-1-0716-2395-4_16
    Book Chapters | 2020
    Jayasena T; Bustamante S; Clement J; Welschinger R; Caplan GA; Sachdev PS; Braidy N, 2020, 'Clinical Assessment of the NADome as Biomarkers for Healthy Aging', in Guest PC (ed.), Clinical and Preclinical Models for Maximizing Healthspan Methods and Protocols, Humana, pp. 207 - 216, http://dx.doi.org/10.1007/978-1-0716-0471-7_13
    Book Chapters | 2020
    Poljak A; Duncan MW; Jayasena T; Sachdev PS, 2020, 'Quantitative Assays of Plasma Apolipoproteins', in Guest PC (ed.), Clinical and Preclinical Models for Maximizing Healthspan. Methods in Molecular Biology, Humana, New York, NY, USA, pp. 49 - 81, http://dx.doi.org/10.1007/978-1-0716-0471-7_3
    Book Chapters | 2017
    Braidy N; Poljak A; Jayasena T; Sachdev PS, 2017, 'Natural Plant-Derived Acetylcholinesterase Inhibitors: Relevance for Alzheimer's Disease', in Andrade PB; Valentao P; Pereira DM (ed.), Natural Products Targeting Clinically Relevant Enzymes, Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany, pp. 297 - 318, http://dx.doi.org/10.1002/9783527805921.ch12
    Book Chapters | 2014
    Braidy N; Poljak A; Jayasena T; Adams S; Sachdev P, 2014, 'Glutamate in the Pathogenesis of Gliomas', in Kostrzewa RM (ed.), Handbook of Neurotoxicity, Springer, New York, USA, pp. 1287 - 1298, http://dx.doi.org/10.1007/978-1-4614-5836-4_149
    Book Chapters | 2014
    Braidy N; Poljak A; Jayasena T; Guillemin GJ; Sachdev P, 2014, 'Ionotropic receptors in the central nervous system and neurodegenerative disease', in Kostrzewa RM (ed.), Handbook for Neurotoxicity, Springer, New York, USA, pp. 1071 - 1092, http://dx.doi.org/10.1007/978-1-4614-5836-4_126
    Book Chapters | 2014
    Braidy N; Poljak A; Jayasena T; Sachdev P, 2014, 'Drug Treatments for Alzheimer’s Disease: Hopes and Challenges', in Kostrzewa RM (ed.), Handbook for Neurotoxicity, Springer, New York, USA, pp. 1173 - 1190, http://dx.doi.org/10.1007/978-1-4614-5836-4_141
  • Journal articles | 2024
    Hansra GK; Jayasena T; Hosoki S; Poljak A; Lam BCP; Rust R; Sagare A; Zlokovic B; Thalamuthu A; Sachdev PS, 2024, 'Fluid biomarkers of the neurovascular unit in cerebrovascular disease and vascular cognitive disorders: A systematic review and meta-analysis', Cerebral Circulation - Cognition and Behavior, 6, http://dx.doi.org/10.1016/j.cccb.2024.100216
    Journal articles | 2024
    Saks DG; Bajorek B; Catts VS; Bentvelzen AC; Jiang J; Wen W; Mather KA; Thalamuthu A; Huang-Lung J; Nivison-Smith L; Griffiths LR; Smith RA; Sexton A; James P; Jayasena T; Poljak A; Hansra GK; Hosoki S; Park A; Hillenbrand CM; van Wijngaarden P; Chander RJ; Humphrey S; Chen R; Kochan NA; Helman TJ; Levi C; Brodtmann A; O'Sullivan MJ; Markus R; Butcher K; Parsons M; Kovacic JC; Sachdev PS, 2024, 'The protocol for an observational Australian cohort study of CADASIL: The AusCADASIL study', Cerebral Circulation - Cognition and Behavior, 6, http://dx.doi.org/10.1016/j.cccb.2024.100225
    Journal articles | 2024
    Solaja I; Haldane K; Mason N; Weiss B; Xu X; Xu M; Nikolin S; Jayasena T; Millard M; Brett J; Bayes A; Loo CK; Martin DM, 2024, 'Who are you after psychedelics? A systematic review and a meta-analysis of the magnitude of long-term effects of serotonergic psychedelics on cognition/creativity, emotional processing and personality', Neuroscience and Biobehavioral Reviews, 158, http://dx.doi.org/10.1016/j.neubiorev.2024.105570
    Journal articles | 2023
    Hosoki S; Hansra GK; Jayasena T; Poljak A; Mather KA; Catts VS; Rust R; Sagare A; Kovacic JC; Brodtmann A; Wallin A; Zlokovic BV; Ihara M; Sachdev PS, 2023, 'Molecular biomarkers for vascular cognitive impairment and dementia', Nature Reviews Neurology, 19, pp. 737 - 753, http://dx.doi.org/10.1038/s41582-023-00884-1
    Journal articles | 2023
    Ong KL; Marklund M; Huang L; Rye KA; Hui N; Pan XF; Rebholz CM; Kim H; Steffen LM; Van Westing AC; Geleijnse JM; Hoogeveen EK; Chen YY; Chien KL; Fretts AM; Lemaitre RN; Imamura F; Forouhi NG; Wareham NJ; Birukov A; Jäger S; Kuxhaus O; Schulze MB; De Mello VD; Tuomilehto J; Uusitupa M; Lindström J; Tintle N; Harris WS; Yamasaki K; Hirakawa Y; Ninomiya T; Tanaka T; Ferrucci L; Bandinelli S; Virtanen JK; Voutilainen A; Jayasena T; Thalamuthu A; Poljak A; Bustamante S; Sachdev PS; Senn MK; Rich SS; Tsai MY; Wood AC; Laakso M; Lankinen M; Yang X; Sun L; Li H; Lin X; Nowak C; Ärnlöv J; Risérus U; Lind L; Le Goff M; Samieri C; Helmer C; Qian F; Micha R; Tin A; Köttgen A; De Boer IH; Siscovick DS; Mozaffarian D; Wu JHY, 2023, 'Association of omega 3 polyunsaturated fatty acids with incident chronic kidney disease: pooled analysis of 19 cohorts', BMJ, http://dx.doi.org/10.1136/bmj-2022-072909
    Journal articles | 2020
    Khorshidi F; Poljak A; Jayasena T; Sachdev PS, 2020, 'Hormetic effects of alcohol in an astroglial cellular model and its proteomics signature', Alzheimer's & Dementia, 16, http://dx.doi.org/10.1002/alz.041665
    Journal articles | 2019
    Braidy N; Berg J; Clement J; Khorshidi F; Poljak A; Jayasena T; Grant R; Sachdev PS, 2019, 'Role of Nicotinamide Adenine Dinucleotide and Related Precursors as Therapeutic Targets for Age-Related Degenerative Diseases: Rationale, Biochemistry, Pharmacokinetics, and Outcomes', Antioxidants and Redox Signaling, 30, pp. 251 - 294, http://dx.doi.org/10.1089/ars.2017.7269
    Journal articles | 2019
    Braidy N; Zarka M; Jugder B-E; Welch J; Jayasena T; Chan DKY; Sachdev P; Bridge W, 2019, 'The Precursor to Glutathione (GSH), γ-Glutamylcysteine (GGC), Can Ameliorate Oxidative Damage and Neuroinflammation Induced by Aβ40 Oligomers in Human Astrocytes', Frontiers in Aging Neuroscience, 11, pp. 1 - 1, http://dx.doi.org/10.3389/fnagi.2019.00177
    Journal articles | 2018
    Bustamante S; Jayasena T; Richani D; Gilchrist RB; Wu LE; Sinclair DA; Sachdev PS; Braidy N, 2018, 'Quantifying the cellular NAD+ metabolome using a tandem liquid chromatography mass spectrometry approach', Metabolomics, 14, http://dx.doi.org/10.1007/s11306-017-1310-z
    Journal articles | 2017
    Braidy N; Jugder B-E; Poljak A; Jayasena T; Nabavi SM; Sachdev P; Grant R, 2017, 'Molecular targets of Tannic Acid in Alzheimer’s disease', Curr Alzheimer Res, 14, http://dx.doi.org/10.2174/1567205014666170206163158
    Journal articles | 2017
    Braidy N; Poljak A; Marjo C; Rutlidge H; Rich A; Jugder B-E; Jayasena T; Inestrosa N; Sachdev P, 2017, 'Identification of cerebral metal ion imbalance in the brain of ageing Octodon degus', Frontiers in Aging Neuroscience, 9, pp. 66 - 66, http://dx.doi.org/10.3389/fnagi.2017.00066
    Journal articles | 2017
    Braidy N; Poljak A; Marjo C; Rutlidge H; Rich A; Jugder BE; Jayasena T; Inestrosa NC; Sachdev PS, 2017, 'Corrigendum: Identification of cerebral metal ion imbalance in the brain of ageing octodon degus [Front. Aging Neurosci., 9, (2017) (66)] DOI: 10.3389/fnagi.2017.00066', Frontiers in Aging Neuroscience, 9, pp. 134, http://dx.doi.org/10.3389/fnagi.2017.00134
    Journal articles | 2016
    Braidy N; Jugder BE; Poljak A; Jayasena T; Mansour H; Nabavi SM; Sachdev P; Grant R, 2016, 'Resveratrol as a potential therapeutic candidate for the treatment and management of alzheimer’s disease', Current Topics in Medicinal Chemistry, 16, pp. 1951 - 1960, http://dx.doi.org/10.2174/1568026616666160204121431
    Journal articles | 2016
    Jayasena T; Poljak A; Braidy N; Zhong L; Rowlands B; Muenchhoff J; Grant R; Smythe G; Teo C; Raftery M; Sachdev PS, 2016, 'Application of targeted mass spectrometry for the quantification of sirtuins in the central nervous system', Scientific Reports, 6, pp. 35391 - 35391, http://dx.doi.org/10.1038/srep35391
    Journal articles | 2015
    Braidy N; Poljak A; Grant R; Jayasena T; Mansour H; Chan-Ling T; Smythe G; Sachdev P; Guillemin GJ, 2015, 'Differential expression of sirtuins in the aging rat brain', Frontiers in Cellular Neuroscience, 9, pp. 167, http://dx.doi.org/10.3389/fncel.2015.00167
    Journal articles | 2015
    Braidy N; Poljak A; Jayasena T; Mansour H; Inestrosa NC; Sachdev PS, 2015, 'Accelerating Alzheimer's research through 'natural' animal models', Current Opinion in Psychiatry, 28, pp. 155 - 164, http://dx.doi.org/10.1097/YCO.0000000000000137
    Journal articles | 2015
    Jayasena T; Poljak A; Braidy N; Smythe G; Raftery M; Hill M; Brodaty H; Trollor J; Kochan N; Sachdev P, 2015, 'Upregulation of glycolytic enzymes, mitochondrial dysfunction and increased cytotoxicity in glial cells treated with Alzheimer's disease plasma', PLoS ONE, 10, pp. e0116092, http://dx.doi.org/10.1371/journal.pone.0116092
    Journal articles | 2014
    Braidy N; Poljak A; Grant R; Jayasena T; Mansour H; Chan-Ling T; Guillemin GJ; Smythe G; Sachdev P, 2014, 'Mapping NAD+ metabolism in the brain of ageing Wistar rats: potential targets for influencing brain senescence', Biogerontology, 15, pp. 177 - 198, http://dx.doi.org/10.1007/s10522-013-9489-5
    Journal articles | 2014
    Braidy N; Poljak A; Marjo C; Rutlidge H; Rich A; Jayasena T; Inestrosa NC; Sachdev P, 2014, 'Metal and complementary molecular bioimaging in alzheimer's disease', Frontiers in Aging Neuroscience, 6, pp. 138, http://dx.doi.org/10.3389/fnagi.2014.00138
    Journal articles | 2013
    Jayasena T; Braidy N; Sachdev P; Poljak A; Smythe G; Münch G, 2013, 'The role of polyphenols in the modulation of sirtuins and other pathways involved in Alzheimer's disease', Ageing Research Reviews, 12, pp. 867 - 883, http://dx.doi.org/10.1016/j.arr.2013.06.003
    Journal articles | 2012
    Braidy N; Jayasena T; Poljak A; Sachdev PS, 2012, 'Sirtuins in cognitive ageing and Alzheimer's disease', Current Opinion in Psychiatry, 25, pp. 226 - 230, http://dx.doi.org/10.1097/YCO.0b013e32835112c1
    Journal articles | 2011
    Song F; Poljak A; Jayasena T; Smythe G; Brodaty H; Kochan N; Sachdev P; Crawford J, 2011, 'P1‐115: Plasma apolipoproteins as biomarkers of mild cognitive impairment in a community‐based sample', Alzheimer's & Dementia, 7, http://dx.doi.org/10.1016/j.jalz.2011.05.394
    Journal articles | 2009
    Braidy N; Grant RS; Brew BJ; Adams S; Jayasena T; Guillemin GJ, 2009, 'Effects of Kynurenine Pathway Metabolites on Intracellular NAD+ Synthesis and Cell Death in Human Primary Astrocytes and Neurons', International Journal of Tryptophan Research : IJTR, 2, pp. 61 - 69
    Journal articles | 2007
    Jayasena T; Grant RS; Keerthisinghe N; Solaja I; Smythe GA, 2007, 'Membrane permeability of redox active metal chelators: An important element in reducing hydroxyl radical induced NAD(+) depletion in neuronal cells', Neuroscience Research, 57, pp. 454 - 461, http://dx.doi.org/10.1016/j.neures.2006.12.004
  • Conference Abstracts | 2017
    Jayasena T; Poljak A; Bustamante S; Braidy N; Raftery MJ; Sachdev PS, 2017, 'Sirtuin protein and related energy metabolite changes in the Alzheimer brain [Poster Abstract P2-182]', in Alzheimer's and Dementia, Elsevier, London, UK, Vol. 13, pp. P676 - P676, presented at lzheimer's Association International Conference (AAIC) 2017, London, UK, 16 July 2017 - 20 July 2017, http://dx.doi.org/10.1016/j.jalz.2017.06.833
    Conference Abstracts | 2013
    Jayasena T; Poljak A; Zhong L; Braidy N; Smythe G; Raftery M; Sachdev P, 2013, 'Development of a targeted mass spectrometry method for accurate quantification of human sirtuins in biological samples [Abstract P2-035]', in Alzheimer's & Dementia, Boston, MA, USA, Vol. 9, pp. P357 - P357, presented at Alzheimer’s Association International Conference (AAIC) 2013, Boston, MA, USA, 13 July 2013 - 18 July 2013, http://dx.doi.org/10.1016/j.jalz.2013.05.677
    Conference Abstracts | 2012
    Braidy N; Jayasena T; Poljak A; Smythe G; Guillemin G; Sachdev P, 2012, 'Sirtuin expression during aging and in Alzheimer's disease [Abstract P2-094]', in Alzheimer's & Dementia, Vancouver, Canada, Vol. 8, pp. P295 - P296, presented at Alzheimer’s Association International Conference (AAIC) 2012, Vancouver, Canada, 14 July 2012 - 19 July 2012, http://dx.doi.org/10.1016/j.jalz.2012.05.798
    Conference Abstracts | 2012
    Braidy N; Poljak A; Jayasena T; Guillemin G; Smythe G; Sachdev P, 2012, 'NAD+ metabolism, and oxidative stress in the brain of aging Wistar rats: Is there a link? [Abstract P3-073]', in Alzheimer's & Dementia, Vancouver, Canada, Vol. 8, pp. P478 - P478, presented at Alzheimer’s Association International Conference (AAIC) 2012, Vancouver, Canada, 14 July 2012 - 19 July 2012, http://dx.doi.org/10.1016/j.jalz.2012.05.1292
    Conference Abstracts | 2010
    Song F; Poljak A; Kochan N; Jayasena T; Raftery M; Brodaty H; Smythe GA; Sachdev PS, 2010, 'Screening plasma for biomarkers of mild cognitive impairment and Alzheimer's disease by quantitative proteomic methods [Abstract O3-03-03]', in Alzheimer's & Dementia, Honolulu, Hawaii, USA, Vol. 6, pp. S129 - S130, presented at Alzheimer’s Association International Conference (AAIC) 2010, Honolulu, Hawaii, USA, 10 July 2010 - 15 July 2010, http://dx.doi.org/10.1016/j.jalz.2010.05.406
    Conference Abstracts | 2009
    Poljak A; Song F; Jayasena T; Smythe GA; Raftery MJ; Brodaty H; Slavin MJ; Kochan NA; Trollor JN; Crawford J; Wen W; Ng LL; Sachdev PS, 2009, 'Diagnostic biomarkers of mild cognitive impairment and Alzheimer's disease: A plasma proteomics approach [Oral Abstract]', in Australasian Journal of Ageing, Canberra, Vol. 28, pp. A71 - A72, presented at 42nd National Conference of the Australian Association of Gerontology, Canberra, 25 November 2009 - 27 November 2009, http://dx.doi.org/10.1111/j.1741-6612.2009.00397.x