Associate Professor Thomas Robert Cox
Conjoint Associate Professor

Associate Professor Thomas Robert Cox

medicine-health
St Vincent's Clinical School

The Matrix and Metastasis Lab is based at the Garvan Institute of Medical Research Kinghorn Cancer Centre in Sydney, Australia.

Research Interests:
Our research focuses on how the extracellular matrix (ECM) and ECM remodelling influences cancer progression, therapy response, and metastasis in solid tumours

Broad Research Areas:
Cancer, Cancer Cell Biology, Biochemistry, Proteomics

Society Memberships & Professional Activities:
Metastasis Research Society (MRS), Matrix Biology Society of Australia & New Zealand (MBSANZ)[Vice-President], British Society for Matrix Biology (BSMB), American Association for Cancer Research (AACR), British Association for Cancer Research (BACR)

Specific Research Keywords:
Extracellular Matrix, Cancer Metastasis, Targetted Therapies,

Phone
02 9355 5825
Location
Garvan Institute of Medial Research The Kinghorn Cancer Centre 384 Victoria St Darlinghurst NSW 2010

Publications

  • Book Chapters | 2020
    Associate Professor Thomas Robert Cox
    Papanicolaou M; Cox TR, 2020, 'Extracellular Matrix (ECM)', in Encyclopedia of Molecular Pharmacology, Springer International Publishing, pp. 1 - 8, http://dx.doi.org/10.1007/978-3-030-21573-6_5691-1
    Book Chapters | 2017
    Associate Professor Thomas Robert Cox
    El Rayes T; Gao D; Altorki NK; Cox TR; Erler JT; Mittal V, 2017, 'Regulation of tumor progression and metastasis by bone marrow-derived microenvironments', in Biomarkers of the Tumor Microenvironment: Basic Studies and Practical Applications, Springer, pp. 303 - 328, http://dx.doi.org/10.1007/978-3-319-39147-2_13
    Book Chapters | 2013
    Associate Professor Thomas Robert Cox
    Cox TR; Erler JT, 2013, 'Remodelling of the extracellular matrix: Implications for cancer', in Cell and Molecular Biology of Breast Cancer, pp. 65 - 90, http://dx.doi.org/10.1007/978-1-62703-634-4_4
  • Journal articles | 2021
    Associate Professor Thomas Robert Cox
    Lakis V; Lawlor RT; Newell F; Patch AM; Mafficini A; Sadanandam A; Koufariotis LT; Johnston RL; Leonard C; Wood S; Rusev B; Corbo V; Luchini C; Cingarlini S; Landoni L; Salvia R; Milella M; Chang D; Bailey P; Jamieson NB; Duthie F; Gingras MC; Muzny DM; Wheeler DA; Gibbs RA; Milione M; Chantrill LA; Timpson P; Chou A; Pajic M; Murphy A; Dwarte T; Hermann D; Vennin C; Cox TR; Pereira B; Ritchie S; Reed DA; Chambers CR; Metcalf X; Nobis M; Mukhopadhyay P; Addala V; Kazakoff S; Holmes O; Xu Q; Hofmann O; Samra JS; Pavlakis N; Arena J; High HA; Asghari R; Merrett ND; Pavey D; Das A; Cosman PH; Ismail K; O’Connnor C; Stoita A; Williams D; Spigellman A; Lam VW; McLeod D; Kirk J; Kench JG; Grimison P; Sandroussi C; Goodwin A; Mead RS; Tucker K; Andrews L; Texler M; Forest C; Ballal M; Fletcher DR; Zeps N; Nguyen NQ; Ruszkiewicz AR; Worthley C; Chen J; Brooke-Smith ME; Papangelis V; Clouston AD; Barbour AP; O’Rourke TJ; Fawcett JW; Slater K; Hatzifotis M; Hodgkinson P; Nikfarjam M; Eshleman JR; Hruban RH; Wolfgang CL; Dixon J; Scardoni M; Bassi C; Grimaldi S; Cantù C; Bonizzato G; Bersani S, 2021, 'DNA methylation patterns identify subgroups of pancreatic neuroendocrine tumors with clinical association', Communications Biology, vol. 4, http://dx.doi.org/10.1038/s42003-020-01469-0
    Journal articles | 2021
    Associate Professor Thomas Robert Cox
    Sharbeen G; McCarroll JA; Akerman A; Kopecky C; Youkhana J; Kokkinos J; Holst J; Boyer C; Erkan M; Goldstein D; Timpson P; Cox TR; Pereira BA; Chitty JL; Fey SK; Najumudeen AK; Campbell AD; Sansom OJ; Ignacio RMC; Naim S; Liu J; Russia N; Lee J; Chou A; Johns A; Gill AJ; Gonzales-Aloy E; Gebski V; Guan YF; Pajic M; Turner N; Apte MV; Davis TP; Morton JP; Haghighi KS; Kasparian J; McLean BJ; Setargew YF; Phillips PA, 2021, 'Cancer-associated fibroblasts in pancreatic ductal adenocarcinoma determine response to slc7a11 inhibition', Cancer Research, vol. 81, pp. 3461 - 3479, http://dx.doi.org/10.1158/0008-5472.CAN-20-2496
    Journal articles | 2021
    Associate Professor Thomas Robert Cox
    Valdés-Mora F; Salomon R; Gloss BS; Law AMK; Venhuizen J; Castillo L; Murphy KJ; Magenau A; Papanicolaou M; Rodriguez de la Fuente L; Roden DL; Colino-Sanguino Y; Kikhtyak Z; Farbehi N; Conway JRW; Sikta N; Oakes SR; Cox TR; O'Donoghue SI; Timpson P; Ormandy CJ; Gallego-Ortega D, 2021, 'Single-cell transcriptomics reveals involution mimicry during the specification of the basal breast cancer subtype', Cell Reports, vol. 35, http://dx.doi.org/10.1016/j.celrep.2021.108945
    Journal articles | 2021
    Associate Professor Thomas Robert Cox
    Cox TR, 2021, 'The matrix in cancer', Nature Reviews Cancer, vol. 21, pp. 217 - 238, http://dx.doi.org/10.1038/s41568-020-00329-7
    Journal articles | 2021
    Associate Professor Thomas Robert Cox
    Polonchuk L; Surija L; Lee MH; Sharma P; Liu Chung Ming C; Richter F; Ben-Sefer E; Alsadat Rad M; Mahmodi Sheikh Sarmast H; Al Shamery W; Tran HA; Vettori L; Haeusermann F; Filipe EC; Rnjak-Kovacina J; Cox T; Tipper J; Kabakova I; Gentile C, 2021, 'Towards engineering heart tissues from bioprinted cardiac spheroids.', Biofabrication, http://dx.doi.org/10.1088/1758-5090/ac14ca
    Journal articles | 2021
    Associate Professor Thomas Robert Cox
    Guo G; Papanicolaou M; Demarais NJ; Wang Z; Schey KL; Timpson P; Cox TR; Grey AC, 2021, 'Automated annotation and visualisation of high-resolution spatial proteomic mass spectrometry imaging data using HIT-MAP', Nature Communications, vol. 12, pp. 3241, http://dx.doi.org/10.1038/s41467-021-23461-w
    Journal articles | 2021
    Associate Professor Thomas Robert Cox
    Filipe EC; Parker AL; Cadell AL; Major G; Croucher DR; Cox TR, 2021, 'In Vitro 3D Models of Tunable Stiffness', Methods Mol Biol, vol. 2294, pp. 27 - 42, http://dx.doi.org/10.1007/978-1-0716-1350-4_3
    Journal articles | 2021
    Associate Professor Thomas Robert Cox
    Setargew YFI; Wyllie K; Grant RD; Chitty JL; Cox TR, 2021, 'Targeting lysyl oxidase family meditated matrix cross‐linking as an anti‐stromal therapy in solid tumours', Cancers, vol. 13, pp. 1 - 26, http://dx.doi.org/10.3390/cancers13030491
    Journal articles | 2021
    Associate Professor Thomas Robert Cox
    Holliday H; Roden D; Junankar S; Wu SZ; Baker LA; Krisp C; Chan CL; McFarland A; Skhinas JN; Cox TR; Pal B; Huntington ND; Ormandy CJ; Carroll JS; Visvader J; Molloy MP; Swarbrick A, 2021, 'Inhibitor of Differentiation 4 (ID4) represses mammary myoepithelial differentiation via inhibition of HEB', iScience, vol. 24, pp. 102072 - 102072, http://dx.doi.org/10.1016/j.isci.2021.102072
    Journal articles | 2020
    Associate Professor Thomas Robert Cox
    Wu SZ; Roden DL; Wang C; Holliday H; Harvey K; Cazet AS; Murphy KJ; Pereira B; Al-Eryani G; Bartonicek N; Hou R; Torpy JR; Junankar S; Chan CL; Lam CE; Hui MN; Gluch L; Beith J; Parker A; Robbins E; Segara D; Mak C; Cooper C; Warrier S; Forrest A; Powell J; O'Toole S; Cox TR; Timpson P; Lim E; Liu XS; Swarbrick A, 2020, 'Stromal cell diversity associated with immune evasion in human triple-negative breast cancer', EMBO Journal, vol. 39, http://dx.doi.org/10.15252/embj.2019104063
    Journal articles | 2020
    Associate Professor Thomas Robert Cox
    Nobis M; Herrmann D; Warren SC; Strathdee D; Cox TR; Anderson KI; Timpson P, 2020, 'Shedding new light on RhoA signalling as a drug target in vivo using a novel RhoA-FRET biosensor mouse', Small GTPases, vol. 11, pp. 240 - 247, http://dx.doi.org/10.1080/21541248.2018.1438024
    Journal articles | 2020
    Associate Professor Thomas Robert Cox
    Chitty JL; Skhinas JN; Filipe EC; Wang S; Cupello CR; Grant RD; Yam M; Papanicolaou M; Major G; Zaratzian A; Da Silva AM; Tayao M; Vennin C; Timpson P; Madsen CD; Cox TR, 2020, 'The Mini-Organo: A rapid high-throughput 3D coculture organotypic assay for oncology screening and drug development', Cancer Reports, vol. 3, http://dx.doi.org/10.1002/cnr2.1209
    Journal articles | 2020
    Associate Professor Thomas Robert Cox
    Michael P; Lam YT; Filipe EC; Tan RP; Chan AHP; Lee BSL; Feng N; Hung J; Cox TR; Santos M; Wise SG, 2020, 'Plasma polymerized nanoparticles effectively deliver dual siRNA and drug therapy in vivo', Scientific Reports, vol. 10, http://dx.doi.org/10.1038/s41598-020-69591-x
    Journal articles | 2020
    Associate Professor Thomas Robert Cox
    Wu S; Roden D; Wang C; Holliday H; Harvey K; Cazet A; Murphy K; Pereira B; Al-Eryani G; Bartonicek N; Hou R; Torpy J; Junankar S; Chan C-L; Lam E; Hui M; Gluch L; Beith J; Parker A; Robbins E; Segara D; Mak C; Cooper C; Warrier S; Forrest A; Powell J; O’Toole S; Cox T; Timpson P; Lim E; Liu S; Swarbrick A, 2020, 'Single-cell analysis reveals diverse stromal subsets associated with immune evasion in triple-negative breast cancer', bioRxiv, http://dx.doi.org/10.1101/2020.06.04.135327
    Journal articles | 2020
    Associate Professor Thomas Robert Cox
    Elgundi Z; Papanicolaou M; Major G; Cox TR; Melrose J; Whitelock JM; Farrugia BL, 2020, 'Cancer Metastasis: The Role of the Extracellular Matrix and the Heparan Sulfate Proteoglycan Perlecan', Frontiers in Oncology, vol. 9, http://dx.doi.org/10.3389/fonc.2019.01482
    Journal articles | 2020
    Associate Professor Thomas Robert Cox
    Parker AL; Cox TR, 2020, 'The Role of the ECM in Lung Cancer Dormancy and Outgrowth', Frontiers in Oncology, vol. 10, http://dx.doi.org/10.3389/fonc.2020.01766
    Journal articles | 2019
    Associate Professor Thomas Robert Cox
    Hastings JF; Skhinas JN; Fey D; Croucher DR; Cox TR, 2019, 'The extracellular matrix as a key regulator of intracellular signalling networks', British Journal of Pharmacology, vol. 176, pp. 82 - 92, http://dx.doi.org/10.1111/bph.14195
    Journal articles | 2019
    Associate Professor Thomas Robert Cox
    Vennin C; Mélénec P; Rouet R; Nobis M; Cazet AS; Murphy KJ; Herrmann D; Reed DA; Lucas MC; Warren SC; Elgundi Z; Pinese M; Kalna G; Roden D; Samuel M; Zaratzian A; Grey ST; Da Silva A; Leung W; Johns AL; Chantrill LA; Chou A; Steinmann A; Arshi M; Dwarte T; Froio D; Pereira B; Ritchie S; Chambers CR; Metcalf X; Waddell N; Pearson JV; Patch AM; Nones K; Newell F; Mukhopadhyay P; Addala V; Kazakoff S; Holmes O; Leonard C; Wood S; Grimmond SM; Hofmann O; Christ A; Bruxner T; Samra JS; Pavlakis N; High HA; Asghari R; Merrett ND; Pavey D; Das A; Cosman PH; Ismail K; O’Connnor C; Stoita A; Williams D; Spigellman A; Lam VW; McLeod D; Kirk J; Kench JG; Grimison P; Cooper CL; Sandroussi C; Goodwin A; Mead RS; Tucker K; Andrews L; Texler M; Forest C; Epari KP; Ballal M; Fletcher DR; Mukhedkar S; Zeps N; Beilin M; Feeney K; Nguyen NQ; Ruszkiewicz AR; Worthley C; Chen J; Brooke-Smith ME; Papangelis V; Clouston AD; Barbour AP; O’Rourke TJ; Fawcett JW; Slater K; Hatzifotis M; Hodgkinson P; Nikfarjam M; Eshleman JR; Hruban RH; Wolfgang CL; Lawlor RT; Beghelli S; Corbo V; Scardoni M; Bassi C, 2019, 'CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan', Nature Communications, vol. 10, pp. 3637, http://dx.doi.org/10.1038/s41467-019-10968-6
    Journal articles | 2019
    Associate Professor Thomas Robert Cox
    Nguyen EV; Pereira BA; Lawrence MG; Ma X; Rebello RJ; Chan H; Niranjan B; Wu Y; Ellem S; Guan X; Wu J; Skhinas JN; Cox TR; Risbridger GP; Taylor RA; Lister NL; Daly RJ, 2019, 'Proteomic profiling of human prostate cancer-associated fibroblasts (CAF) reveals LOXL2-dependent regulation of the tumor microenvironment', Molecular and Cellular Proteomics, vol. 18, pp. 1410 - 1427, http://dx.doi.org/10.1074/mcp.RA119.001496
    Journal articles | 2019
    Associate Professor Thomas Robert Cox
    Pereira BA; Vennin C; Papanicolaou M; Chambers CR; Herrmann D; Morton JP; Cox TR; Timpson P, 2019, 'CAF Subpopulations: A New Reservoir of Stromal Targets in Pancreatic Cancer', Trends in Cancer, vol. 5, pp. 724 - 741, http://dx.doi.org/10.1016/j.trecan.2019.09.010
    Journal articles | 2019
    Associate Professor Thomas Robert Cox
    Kennedy SP; Han JZR; Portman N; Nobis M; Hastings JF; Murphy KJ; Latham SL; Cadell AL; Miladinovic D; Marriott GR; O'Donnell YEI; Shearer RF; Williams JT; Munoz AG; Cox TR; Watkins DN; Saunders DN; Timpson P; Lim E; Kolch W; Croucher DR, 2019, 'Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer', Breast Cancer Research, vol. 21, pp. 43, http://dx.doi.org/10.1186/s13058-019-1127-y
    Journal articles | 2019
    Associate Professor Thomas Robert Cox
    Chitty JL; Setargew YFI; Cox TR, 2019, 'Targeting the lysyl oxidases in tumour desmoplasia', Biochemical Society Transactions, vol. 47, pp. 1661 - 1678, http://dx.doi.org/10.1042/BST20190098
    Journal articles | 2019
    Associate Professor Thomas Robert Cox
    Zeltz C; Pasko E; Cox TR; Navab R; Tsao MS, 2019, 'LOXL1 is regulated by integrin α11 and promotes non-small cell lung cancer tumorigenicity', Cancers, vol. 11, http://dx.doi.org/10.3390/cancers11050705
    Journal articles | 2019
    Associate Professor Thomas Robert Cox
    Zijlstra A; Von Lersner A; Yu D; Borrello L; Oudin M; Kang Y; Sahai E; Fingleton B; Stein U; Cox TR; Price JT; Kato Y; Welm AL; Aguirre-Ghiso JA, 2019, 'The importance of developing therapies targeting the biological spectrum of metastatic disease', Clinical and Experimental Metastasis, vol. 36, pp. 305 - 309, http://dx.doi.org/10.1007/s10585-019-09972-3
    Journal articles | 2019
    Associate Professor Thomas Robert Cox
    Beadnell T; Borriello L; Christenson J; Fornetti J; Guldner I; Hanna A; Kyjacova L; Marinak-Whately K; de Melo Martins PC; Rotinen M; te Boekhorst V; Cox TR, 2019, 'Meeting report: Metastasis Research Society (MRS) 17th Biennial conference and associated Young Investigator Satellite Meeting (YISM) on cancer metastasis', Clinical and Experimental Metastasis, vol. 36, pp. 119 - 137, http://dx.doi.org/10.1007/s10585-018-09953-y
    Journal articles | 2019
    Associate Professor Thomas Robert Cox
    Nguyen EV; Pereira BA; Lawrence MG; Ma X; Rebello RJ; Chan H; Niranjan B; Wu Y; Ellem S; Guan X; Wu J; Skhinas JN; Cox TR; Risbridger GP; Taylor RA; Lister NL; Daly RJ, 2019, 'Proteomic Profiling of Human Prostate Cancer-associated Fibroblasts (CAF) Reveals LOXL2-dependent Regulation of the Tumor Microenvironment.', Mol Cell Proteomics, vol. 18, pp. 1410 - 1427, http://dx.doi.org/10.1074/mcp.RA119.001496
    Journal articles | 2018
    Associate Professor Thomas Robert Cox
    Høye AM; Tolstrup SD; Horton ER; Nicolau M; Frost H; Woo JH; Mauldin JP; Frankel AE; Cox TR; Erler JT, 2018, 'Tumor endothelial marker 8 promotes cancer progression and metastasis', Oncotarget, vol. 9, pp. 30173 - 30188, http://dx.doi.org/10.18632/oncotarget.25734
    Journal articles | 2018
    Associate Professor Thomas Robert Cox
    Filipe EC; Chitty JL; Cox TR, 2018, 'Charting the unexplored extracellular matrix in cancer', International Journal of Experimental Pathology, vol. 99, pp. 58 - 76, http://dx.doi.org/10.1111/iep.12269
    Journal articles | 2018
    Associate Professor Thomas Robert Cox
    Xia T; Horton ER; Salcini AE; Pocock R; Cox TR; Erler JT, 2018, 'Proteomic Characterization of Caenorhabditis elegans Larval Development', Proteomics, vol. 18, http://dx.doi.org/10.1002/pmic.201700238
    Journal articles | 2018
    Associate Professor Thomas Robert Cox
    Skhinas JN; Cox TR, 2018, 'The interplay between extracellular matrix remodelling and kinase signalling in cancer progression and metastasis', Cell Adhesion and Migration, vol. 12, pp. 529 - 537, http://dx.doi.org/10.1080/19336918.2017.1405208
    Journal articles | 2018
    Associate Professor Thomas Robert Cox
    Cox TR; Erler JT; Rumney RMH, 2018, 'Established Models and New Paradigms for Hypoxia-Driven Cancer-Associated Bone Disease', Calcified Tissue International, vol. 102, pp. 163 - 173, http://dx.doi.org/10.1007/s00223-017-0352-6
    Journal articles | 2018
    Associate Professor Thomas Robert Cox
    Wullkopf L; West AKV; Leijnse N; Cox TR; Madsen CD; Oddershede LB; Erler JT, 2018, 'Cancer cells' ability to mechanically adjust to extracellular matrix stiffness correlates with their invasive potential', Molecular Biology of the Cell, vol. 29, pp. 2378 - 2385, http://dx.doi.org/10.1091/mbc.E18-05-0319
    Journal articles | 2018
    Associate Professor Thomas Robert Cox
    Chou A; Froio D; Nagrial AM; Parkin A; Murphy KJ; Chin VT; Wohl D; Steinmann A; Stark R; Drury A; Walters SN; Vennin C; Burgess A; Pinese M; Chantrill LA; Cowley MJ; Molloy TJ; Waddell N; Johns A; Grimmond SM; Chang DK; Biankin AV; Sansom OJ; Morton JP; Grey ST; Cox TR; Turchini J; Samra J; Clarke SJ; Timpson P; Gill AJ; Pajic M, 2018, 'Tailored first-line and second-line CDK4-targeting treatment combinations in mouse models of pancreatic cancer', Gut, vol. 67, pp. 2142 - 2155, http://dx.doi.org/10.1136/gutjnl-2017-315144
    Journal articles | 2018
    Associate Professor Thomas Robert Cox
    Chitty JL; Filipe EC; Lucas MC; Herrmann D; Cox TR; Timpson P, 2018, 'Recent advances in understanding the complexities of metastasis', F1000Research, vol. 7, http://dx.doi.org/10.12688/f1000research.15064.2
    Journal articles | 2018
    Associate Professor Thomas Robert Cox
    Cazet AS; Hui MN; Elsworth BL; Wu SZ; Roden D; Chan CL; Skhinas JN; Collot R; Yang J; Harvey K; Johan MZ; Cooper C; Nair R; Herrmann D; McFarland A; Deng N; Ruiz-Borrego M; Rojo F; Trigo JM; Bezares S; Caballero R; Lim E; Timpson P; O’Toole S; Watkins DN; Cox TR; Samuel MS; Martín M; Swarbrick A, 2018, 'Targeting stromal remodeling and cancer stem cell plasticity overcomes chemoresistance in triple negative breast cancer', Nature Communications, vol. 9, http://dx.doi.org/10.1038/s41467-018-05220-6
    Journal articles | 2018
    Associate Professor Thomas Robert Cox
    Vennin C; Murphy KJ; Morton JP; Cox TR; Pajic M; Timpson P, 2018, 'Reshaping the Tumor Stroma for Treatment of Pancreatic Cancer', Gastroenterology, vol. 154, pp. 820 - 838, http://dx.doi.org/10.1053/j.gastro.2017.11.280
    Journal articles | 2018
    Associate Professor Thomas Robert Cox
    Warren SC; Nobis M; Magenau A; Mohammed YH; Herrmann D; Moran I; Vennin C; Conway JRW; Mélénec P; Cox TR; Wang Y; Morton JP; Welch HCE; Strathdee D; Anderson KI; Phan TG; Roberts MS; Timpson P, 2018, 'Removing physiological motion from Intravital and clinical functional imaging data', eLife, vol. 7, http://dx.doi.org/10.7554/eLife.35800
    Journal articles | 2018
    Associate Professor Thomas Robert Cox
    Murphy K; Vennin C; Cox T; Wang Y; Morton J; Sansom O; Pajic M; Herrmann D; Timpson P, 2018, 'PO-229 Transient tissue ‘priming’ via FAK inhibition to impair pancreatic ductal adenocarcinoma (PDAC) progression to improve sensitivity to gemcitabine/abraxane', ESMO Open, vol. 3, pp. A316 - A317, http://dx.doi.org/10.1136/esmoopen-2018-eacr25.746
    Journal articles | 2017
    Associate Professor Thomas Robert Cox
    Elyas E; Papaevangelou E; Alles EJ; Erler JT; Cox TR; Robinson SP; Bamber JC, 2017, 'Correlation of ultrasound shear wave elastography with pathological analysis in a xenografic tumour model', Scientific Reports, vol. 7, http://dx.doi.org/10.1038/s41598-017-00144-5
    Journal articles | 2017
    Associate Professor Thomas Robert Cox
    Elyas E; Grimwood A; Erler JT; Robinson SP; Cox TR; Woods D; Clowes P; De Luca R; Marinozzi F; Fromageau J; Bamber JC, 2017, 'Multi-channel optical coherence elastography using relative and absolute shear-wave time of flight', PLoS ONE, vol. 12, http://dx.doi.org/10.1371/journal.pone.0169664
    Journal articles | 2017
    Associate Professor Thomas Robert Cox
    Liu N; Cox TR; Cui W; Adell G; Holmlund B; Ping J; Jarlsfelt I; Erler JT; Sun XF, 2017, 'Nuclear expression of lysyl oxidase enzyme is an independent prognostic factor in rectal cancer patients', Oncotarget, vol. 8, pp. 60015 - 60024, http://dx.doi.org/10.18632/oncotarget.9623
    Journal articles | 2017
    Associate Professor Thomas Robert Cox
    Koplev S; Longden J; Ferkinghoff-Borg J; Blicher Bjerregård M; Cox TR; Erler JT; Pedersen JT; Voellmy F; Sommer MOA; Linding R, 2017, 'Dynamic Rearrangement of Cell States Detected by Systematic Screening of Sequential Anticancer Treatments', Cell Reports, vol. 20, pp. 2784 - 2791, http://dx.doi.org/10.1016/j.celrep.2017.08.095
    Journal articles | 2017
    Associate Professor Thomas Robert Cox
    Fingleton B; Lange K; Caldwell B; Bankaitis KV; Kang Y; Yu D; Aguirre-Ghiso J; Cox TR; Erler JT; Gelman IH; Hurst DR; Kato Y; Lynch CC; Price JT; Samant RS; Sleeman J; Stein U; Zijlstra A, 2017, 'Perspective on the interpretation of research and translation to clinical care with therapy-associated metastatic breast cancer progression as an example', Clinical and Experimental Metastasis, vol. 34, pp. 443 - 447, http://dx.doi.org/10.1007/s10585-017-9872-8
    Journal articles | 2017
    Associate Professor Thomas Robert Cox
    Peinado H; Zhang H; Matei IR; Costa-Silva B; Hoshino A; Rodrigues G; Psaila B; Kaplan RN; Bromberg JF; Kang Y; Bissell MJ; Cox TR; Giaccia AJ; Erler JT; Hiratsuka S; Ghajar CM; Lyden D, 2017, 'Pre-metastatic niches: Organ-specific homes for metastases', Nature Reviews Cancer, vol. 17, pp. 302 - 317, http://dx.doi.org/10.1038/nrc.2017.6
    Journal articles | 2017
    Associate Professor Thomas Robert Cox
    Chang J; Lucas MC; Leonte LE; Garcia-Montolio M; Singh LB; Findlay AD; Deodhar M; Foot JS; Jarolimek W; Timpson P; Erler JT; Cox TR, 2017, 'Pre-clinical evaluation of small molecule LOXL2 inhibitors in breast cancer', Oncotarget, vol. 8, pp. 26066 - 26078, http://dx.doi.org/10.18632/oncotarget.15257
    Journal articles | 2017
    Associate Professor Thomas Robert Cox
    Vennin C; Cox TR; Pajic M; Timpson P, 2017, 'Transient targeting of the pancreatic cancer stroma as a 'finetuned' anti-tumor and anti-metastatic therapy', Oncotarget, vol. 8, pp. 84635 - 84636, http://dx.doi.org/10.18632/oncotarget.21468
    Journal articles | 2017
    Associate Professor Thomas Robert Cox
    Conway JRW; Vennin C; Cazet AS; Herrmann D; Murphy KJ; Warren SC; Wullkopf L; Boulghourjian A; Zaratzian A; Da Silva AM; Pajic M; Morton JP; Cox TR; Timpson P, 2017, 'Three-dimensional organotypic matrices from alternative collagen sources as pre-clinical models for cell biology', Scientific Reports, vol. 7, http://dx.doi.org/10.1038/s41598-017-17177-5
    Journal articles | 2017
    Associate Professor Thomas Robert Cox
    Vennin C; Chin VT; Warren SC; Lucas MC; Herrmann D; Magenau A; Melenec P; Walters SN; Del Monte-Nieto G; Conway JRW; Nobis M; Allam AH; McCloy RA; Currey N; Pinese M; Boulghourjian A; Zaratzian A; Adam AAS; Heu C; Nagrial AM; Chou A; Steinmann A; Drury A; Froio D; Giry-Laterriere M; Harris NLE; Phan T; Jain R; Weninger W; McGhee EJ; Whan R; Johns AL; Samra JS; Chantrill L; Gill AJ; Kohonen-Corish M; Harvey RP; Biankin AV; Evans TRJ; Anderson KI; Grey ST; Ormandy CJ; Gallego-Ortega D; Wang Y; Samuel MS; Sansom OJ; Burgess A; Cox TR; Morton JP; Pajic M; Timpson P, 2017, 'Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis', Science Translational Medicine, vol. 9, http://dx.doi.org/10.1126/scitranslmed.aai8504
    Journal articles | 2017
    Associate Professor Thomas Robert Cox
    Mayorca-Guiliani AE; Madsen CD; Cox TR; Horton ER; Venning FA; Erler JT, 2017, 'ISDoT: In situ decellularization of tissues for high-resolution imaging and proteomic analysis of native extracellular matrix', Nature Medicine, vol. 23, pp. 890 - 898, http://dx.doi.org/10.1038/nm.4352
    Journal articles | 2017
    Associate Professor Thomas Robert Cox
    Bankaitis K; Borriello L; Cox T; Lynch C; Zijlstra A; Fingleton B; Gužvić M; Anderson R; Neman J, 2017, 'Meeting report: Metastasis Research Society–Chinese Tumor Metastasis Society joint conference on metastasis', Clinical and Experimental Metastasis, vol. 34, pp. 203 - 213, http://dx.doi.org/10.1007/s10585-017-9842-1
    Journal articles | 2017
    Associate Professor Thomas Robert Cox
    Liu N; Cox TR; Cui W; Adell G; Holmlund B; Ping J; Jarlsfelt I; Erler JT; Sun X-F, 2017, 'Nuclear expression of lysyl oxidase enzyme is an independent prognostic factor in rectal cancer patients.', Oncotarget, vol. 8, pp. 60015 - 60024, http://dx.doi.org/10.18632/oncotarget.9623
    Journal articles | 2017
    Associate Professor Thomas Robert Cox
    Madsen CD; Cox TR, 2017, 'Relative Stiffness Measurements of Tumour Tissues by Shear Rheology', BIO-PROTOCOL, vol. 7, http://dx.doi.org/10.21769/BioProtoc.2265
    Journal articles | 2017
    Associate Professor Thomas Robert Cox
    Cox T; Madsen C, 2017, 'Relative Stiffness Measurements of Cell-embedded Hydrogels by Shear Rheology in vitro', BIO-PROTOCOL, vol. 7, http://dx.doi.org/10.21769/bioprotoc.2101
    Journal articles | 2016
    Associate Professor Thomas Robert Cox
    Cox TR; Gartland A; Erler JT, 2016, 'Lysyl oxidase, a targetable secreted molecule involved in cancer metastasis', Cancer Research, vol. 76, pp. 188 - 192, http://dx.doi.org/10.1158/0008-5472.CAN-15-2306
    Journal articles | 2016
    Associate Professor Thomas Robert Cox
    Gartland A; Erler JT; Cox TR, 2016, 'The role of lysyl oxidase, the extracellular matrix and the pre-metastatic niche in bone metastasis', Journal of Bone Oncology, vol. 5, pp. 100 - 103, http://dx.doi.org/10.1016/j.jbo.2016.04.001
    Journal articles | 2016
    Associate Professor Thomas Robert Cox
    Cox TR; Erler JT, 2016, 'Fibrosis and Cancer: Partners in Crime or Opposing Forces?', Trends in Cancer, vol. 2, pp. 279 - 282, http://dx.doi.org/10.1016/j.trecan.2016.05.004
    Journal articles | 2015
    Associate Professor Thomas Robert Cox
    Madsen CD; Pedersen JT; Venning FA; Singh LB; Moeendarbary E; Charras G; Cox TR; Sahai E; Erler JT, 2015, 'Hypoxia and loss of PHD2 inactivate stromal fibroblasts to decrease tumour stiffness and metastasis', EMBO Reports, vol. 16, pp. 1394 - 1408, http://dx.doi.org/10.15252/embr.201540107
    Journal articles | 2015
    Associate Professor Thomas Robert Cox
    Cox TR; Rumney RMH; Schoof EM; Perryman L; Høye AM; Agrawal A; Bird D; Latif NA; Forrest H; Evans HR; Huggins ID; Lang G; Linding R; Gartland A; Erler JT, 2015, 'The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase', Nature, vol. 522, pp. 106 - 110, http://dx.doi.org/10.1038/nature14492
    Journal articles | 2015
    Associate Professor Thomas Robert Cox
    Creixell P; Schoof EM; Simpson CD; Longden J; Miller CJ; Lou HJ; Perryman L; Cox TR; Zivanovic N; Palmeri A; Wesolowska-Andersen A; Helmer-Citterich M; Ferkinghoff-Borg J; Itamochi H; Bodenmiller B; Erler JT; Turk BE; Linding R, 2015, 'Kinome-wide Decoding of Network-Attacking Mutations Rewiring Cancer Signaling', Cell, vol. 163, pp. 202 - 217, http://dx.doi.org/10.1016/j.cell.2015.08.056
    Journal articles | 2015
    Associate Professor Thomas Robert Cox
    Rodriguez-Teja M; Gronau JH; Breit C; Zhang YZ; Minamidate A; Caley MP; McCarthy A; Cox TR; Erler JT; Gaughan L; Darby S; Robson C; Mauri F; Waxman J; Sturge J, 2015, 'AGE-modified basement membrane cooperates with Endo180 to promote epithelial cell invasiveness and decrease prostate cancer survival', Journal of Pathology, vol. 235, pp. 581 - 592, http://dx.doi.org/10.1002/path.4485
    Journal articles | 2015
    Associate Professor Thomas Robert Cox
    Cox TR; Schoof EM; Gartland A; Erler JT; Linding R, 2015, 'Dataset for the proteomic inventory and quantitative analysis of the breast cancer hypoxic secretome associated with osteotropism', Data in Brief, vol. 5, pp. 621 - 625, http://dx.doi.org/10.1016/j.dib.2015.09.039
    Journal articles | 2014
    Associate Professor Thomas Robert Cox
    Cox TR; Erler JT, 2014, 'Molecular pathways: Connecting fibrosis and solid tumor metastasis', Clinical Cancer Research, vol. 20, pp. 3637 - 3643, http://dx.doi.org/10.1158/1078-0432.CCR-13-1059
    Journal articles | 2014
    Associate Professor Thomas Robert Cox
    Cox TR; Erler JT, 2014, 'Fibrosis, cancer and the premetastatic niche', Breast Cancer Management, vol. 3, pp. 453 - 455, http://dx.doi.org/10.2217/bmt.14.36
    Journal articles | 2013
    Associate Professor Thomas Robert Cox
    Baker AM; Bird D; Welti JC; Gourlaouen M; Lang G; Murray GI; Reynolds AR; Cox TR; Erler JT, 2013, 'Lysyl oxidase plays a critical role in endothelial cell stimulation to drive tumor angiogenesis', Cancer Research, vol. 73, pp. 583 - 594, http://dx.doi.org/10.1158/0008-5472.CAN-12-2447
    Journal articles | 2013
    Associate Professor Thomas Robert Cox
    Cox TR; Erler JT, 2013, 'Lysyl oxidase in colorectal cancer', American Journal of Physiology - Gastrointestinal and Liver Physiology, vol. 305, http://dx.doi.org/10.1152/ajpgi.00425.2012
    Journal articles | 2013
    Associate Professor Thomas Robert Cox
    Baker AM; Bird D; Lang G; Cox TR; Erler JT, 2013, 'Lysyl oxidase enzymatic function increases stiffness to drive colorectal cancer progression through FAK', Oncogene, vol. 32, pp. 1863 - 1868, http://dx.doi.org/10.1038/onc.2012.202
    Journal articles | 2013
    Associate Professor Thomas Robert Cox
    Chang J; Nicolau MM; Cox TR; Wetterskog D; Martens JWM; E Barker H; Erler JT, 2013, 'LOXL2 induces aberrant acinar morphogenesis via ErbB2 signaling', Breast Cancer Research, vol. 15, http://dx.doi.org/10.1186/bcr3461
    Journal articles | 2013
    Associate Professor Thomas Robert Cox
    Cox TR; Bird D; Baker AM; Barker HE; Ho MWY; Lang G; Erler JT, 2013, 'LOX-mediated collagen crosslinking is responsible for fibrosis-enhanced metastasis', Cancer Research, vol. 73, pp. 1721 - 1732, http://dx.doi.org/10.1158/0008-5472.CAN-12-2233
    Journal articles | 2013
    Associate Professor Thomas Robert Cox
    R Cox T, 2013, 'The Importance of LOX Family Members on Modulating Cell-ECM Interactions in Carcinogenesis', Journal of Carcinogenesis & Mutagenesis, vol. S13, http://dx.doi.org/10.4172/2157-2518.s13-001
    Journal articles | 2012
    Associate Professor Thomas Robert Cox
    Cox TR; Gartland A; Erler JT, 2012, 'The pre-metastatic niche: is metastasis random?', Bonekey Rep, vol. 1, pp. 80, http://dx.doi.org/10.1038/bonekey.2012.80
    Journal articles | 2012
    Associate Professor Thomas Robert Cox
    Barker HE; Cox TR; Erler JT, 2012, 'The rationale for targeting the LOX family in cancer', Nature Reviews Cancer, vol. 12, pp. 540 - 552, http://dx.doi.org/10.1038/nrc3319
    Journal articles | 2012
    Associate Professor Thomas Robert Cox
    Cox TR; Erler JT, 2012, 'Network biology and the 3-Dimensional tumor microenvironment: personalizing medicine for the future', Tumor Microenvironment and Therapy, vol. 1, http://dx.doi.org/10.2478/tumor-2012-0002
    Journal articles | 2011
    Associate Professor Thomas Robert Cox
    Baker AM; Cox TR; Bird D; Lang G; Murray GI; Sun XF; Southall SM; Wilson JR; Erler JT, 2011, 'The role of lysyl oxidase in SRC-dependent proliferation and metastasis of colorectal cancer', Journal of the National Cancer Institute, vol. 103, pp. 407 - 424, http://dx.doi.org/10.1093/jnci/djq569
    Journal articles | 2011
    Associate Professor Thomas Robert Cox
    Barker HE; Chang J; Cox TR; Lang G; Bird D; Nicolau M; Evans HR; Gartland A; Erler JT, 2011, 'LOXL2-mediated matrix remodeling in metastasis and mammary gland involution', Cancer Research, vol. 71, pp. 1561 - 1572, http://dx.doi.org/10.1158/0008-5472.CAN-10-2868
    Journal articles | 2011
    Associate Professor Thomas Robert Cox
    Cox TR; Erler JT, 2011, 'Remodeling and homeostasis of the extracellular matrix: Implications for fibrotic diseases and cancer', DMM Disease Models and Mechanisms, vol. 4, pp. 165 - 178, http://dx.doi.org/10.1242/dmm.004077
    Journal articles | 2011
    Associate Professor Thomas Robert Cox
    Evans HR; Ab Latif N; Cox TR; Bird D; Lang G; Erler JT; Gartland* A, 2011, 'Tumour-secreted lox mediates osteolytic bone metastases prior to metastatic tumour cell colonisation', Bone, vol. 48, pp. S21 - S21, http://dx.doi.org/10.1016/j.bone.2010.10.054
    Journal articles | 2010
    Associate Professor Thomas Robert Cox
    Graham HK; Hodson NW; Hoyland JA; Millward-Sadler SJ; Garrod D; Scothern A; Griffiths CEM; Watson REB; Cox TR; Erler JT; Trafford AW; Sherratt MJ, 2010, 'Tissue section AFM: In situ ultrastructural imaging of native biomolecules', Matrix Biology, vol. 29, pp. 254 - 260, http://dx.doi.org/10.1016/j.matbio.2010.01.008
    Journal articles | 2009
    Associate Professor Thomas Robert Cox
    Erler JT; Bennewith KL; Cox TR; Lang G; Bird D; Koong A; Le QT; Giaccia AJ, 2009, 'Hypoxia-Induced Lysyl Oxidase Is a Critical Mediator of Bone Marrow Cell Recruitment to Form the Premetastatic Niche', Cancer Cell, vol. 15, pp. 35 - 44, http://dx.doi.org/10.1016/j.ccr.2008.11.012
  • Conference Abstracts | 2018
    Associate Professor Thomas Robert Cox
    Hui MN; Cazet A; Elsworth B; Roden D; Cox T; Yang J; McFarland A; Deng N; Chan C-L; O'Toole S; Swarbrick A, 2018, 'Targeting the Hedgehog signalling pathway in triple negative breast cancer.', in JOURNAL OF CLINICAL ONCOLOGY, AMER SOC CLINICAL ONCOLOGY, Vol. 36, http://dx.doi.org/10.1200/JCO.2018.36.15_suppl.e24216
    Conference Papers | 2016
    Associate Professor Thomas Robert Cox
    Høye AM; Tolstrup S; Cox TR; Mauldin JP; Frankel AE; Erler JT, 2016, 'Abstract B17: Disrupting tumor growth through targeting TEM8', in Therapeutic Targeting Tumor Microenvironment, American Association for Cancer Research, presented at Abstracts: AACR Special Conference: The Function of Tumor Microenvironment in Cancer Progression; January 7-10, 2016; San Diego, CA, http://dx.doi.org/10.1158/1538-7445.tme16-b17
    Conference Papers | 2016
    Associate Professor Thomas Robert Cox
    Liu N; Cox TR; Cui W; Adell G; Holmlund B; Erler JT; Sun X, 2016, 'Abstract 5012: Nuclear expression of lysyl oxidase enzyme is an independent prognostic factor in rectal cancer patients', in Clinical Research (Excluding Clinical Trials), American Association for Cancer Research, presented at Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA, http://dx.doi.org/10.1158/1538-7445.am2016-5012

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