Associate Professor Thomas Cox
Conjoint Associate Professor

Associate Professor Thomas Cox

Medicine & Health
School of Clinical Medicine

The Matrix and Metastasis Lab is based at the Garvan Institute of Medical Research Kinghorn Cancer Centre in Sydney, Australia.

Research Interests:
Our research focuses on how the extracellular matrix (ECM) and ECM remodelling influences cancer progression, therapy response, and metastasis in solid tumours

Broad Research Areas:
Cancer, Cancer Cell Biology, Biochemistry, Proteomics

Society Memberships & Professional Activities:
Metastasis Research Society (MRS), Matrix Biology Society of Australia & New Zealand (MBSANZ)[President], British Society for Matrix Biology (BSMB), American Association for Cancer Research (AACR), British Association for Cancer Research (BACR)

Specific Research Keywords:
Extracellular Matrix, Cancer Metastasis, Targetted Therapies,

Phone
02 9355 5825
Location
Garvan Institute of Medial Research The Kinghorn Cancer Centre 384 Victoria St Darlinghurst NSW 2010
  • Book Chapters | 2022
    2022, 'Regulation of Tumor Progression and Metastasis by Bone Marrow-Derived Microenvironments', in Biomarkers of the Tumor Microenvironment, Springer International Publishing, pp. 245 - 266, http://dx.doi.org/10.1007/978-3-030-98950-7_14
    Book Chapters | 2021
    2021, 'Extracellular Matrix (ECM)', in Encyclopedia of Molecular Pharmacology, Springer International Publishing, pp. 643 - 650, http://dx.doi.org/10.1007/978-3-030-57401-7_5691
    Book Chapters | 2021
    2021, 'In Vitro 3D Models of Tunable Stiffness', in Metastasis: Methods and Protocols, United States, pp. 27 - 42, http://dx.doi.org/10.1007/978-1-0716-1350-4_3
    Book Chapters | 2020
    2020, 'Extracellular Matrix (ECM)', in Encyclopedia of Molecular Pharmacology, Springer International Publishing, pp. 1 - 8, http://dx.doi.org/10.1007/978-3-030-21573-6_5691-1
    Book Chapters | 2017
    2017, 'Regulation of tumor progression and metastasis by bone marrow-derived microenvironments', in Biomarkers of the Tumor Microenvironment: Basic Studies and Practical Applications, Springer, pp. 303 - 328, http://dx.doi.org/10.1007/978-3-319-39147-2_13
    Book Chapters | 2013
    Cox TR; Erler JT, 2013, 'Remodelling of the extracellular matrix: Implications for cancer', in Cell and Molecular Biology of Breast Cancer, pp. 65 - 90, http://dx.doi.org/10.1007/978-1-62703-634-4_4
  • Journal articles | 2023
    2023, 'Memory of stochastic single-cell apoptotic signaling promotes chemoresistance in neuroblastoma', Science Advances, 9, pp. eabp8314, http://dx.doi.org/10.1126/sciadv.abp8314
    Journal articles | 2023
    2023, 'Spatial analysis of the metastatic brain tumor immune and extracellular matrix microenvironment', Advances in Cancer Biology - Metastasis, 7, pp. 100096 - 100096, http://dx.doi.org/10.1016/j.adcanc.2023.100096
    Journal articles | 2022
    2022, 'ALTEN: A High-Fidelity Primary Tissue-Engineering Platform to Assess Cellular Responses Ex Vivo', Advanced Science, 9, http://dx.doi.org/10.1002/advs.202103332
    Journal articles | 2022
    2022, 'Bovine and human endometrium-derived hydrogels support organoid culture from healthy and cancerous tissues', Proceedings of the National Academy of Sciences of the United States of America, 119, http://dx.doi.org/10.1073/pnas.2208040119
    Journal articles | 2022
    2022, 'Dynamic dentin: A quantitative microscopic assessment of age and spatial changes to matrix architecture, peritubular dentin, and collagens types I and III', Journal of Structural Biology, 214, http://dx.doi.org/10.1016/j.jsb.2022.107899
    Journal articles | 2022
    2022, 'Extracellular matrix profiles determine risk and prognosis of the squamous cell carcinoma subtype of non-small cell lung carcinoma', Genome Medicine, 14, http://dx.doi.org/10.1186/s13073-022-01127-6
    Journal articles | 2022
    2022, 'Genomic and Molecular Analyses Identify Molecular Subtypes of Pancreatic Cancer Recurrence', Gastroenterology, 162, pp. 320 - 324.e4, http://dx.doi.org/10.1053/j.gastro.2021.09.022
    Journal articles | 2022
    2022, 'Micromechanical characterisation of 3D bioprinted neural cell models using Brillouin microspectroscopy', Bioprinting, 25, pp. e00179 - e00179, http://dx.doi.org/10.1016/j.bprint.2021.e00179
    Journal articles | 2022
    2022, 'Temporal profiling of the breast tumour microenvironment reveals collagen XII as a driver of metastasis', Nature Communications, 13, pp. 4587, http://dx.doi.org/10.1038/s41467-022-32255-7
    Journal articles | 2021
    2021, 'Automated annotation and visualisation of high-resolution spatial proteomic mass spectrometry imaging data using HIT-MAP', Nature Communications, 12, pp. 3241, http://dx.doi.org/10.1038/s41467-021-23461-w
    Journal articles | 2021
    2021, 'Cancer-associated fibroblasts in pancreatic ductal adenocarcinoma determine response to slc7a11 inhibition', Cancer Research, 81, pp. 3461 - 3479, http://dx.doi.org/10.1158/0008-5472.CAN-20-2496
    Journal articles | 2021
    2021, 'DNA methylation patterns identify subgroups of pancreatic neuroendocrine tumors with clinical association', Communications Biology, 4, http://dx.doi.org/10.1038/s42003-020-01469-0
    Journal articles | 2021
    2021, 'Inhibitor of Differentiation 4 (ID4) represses mammary myoepithelial differentiation via inhibition of HEB', iScience, 24, pp. 102072 - 102072, http://dx.doi.org/10.1016/j.isci.2021.102072
    Journal articles | 2021
    2021, 'Intravital imaging technology guides FAK-mediated priming in pancreatic cancer precision medicine according to Merlin status', Science Advances, 7, http://dx.doi.org/10.1126/sciadv.abh0363
    Journal articles | 2021
    2021, 'Pirfenidone reduces epithelial–mesenchymal transition and spheroid formation in breast carcinoma through targeting cancer-associated fibroblasts (Cafs)', Cancers, 13, http://dx.doi.org/10.3390/cancers13205118
    Journal articles | 2021
    2021, 'ROR1 and ROR2 expression in pancreatic cancer', BMC Cancer, 21, pp. 1199, http://dx.doi.org/10.1186/s12885-021-08952-9
    Journal articles | 2021
    2021, 'Single-cell transcriptomics reveals involution mimicry during the specification of the basal breast cancer subtype', Cell Reports, 35, http://dx.doi.org/10.1016/j.celrep.2021.108945
    Journal articles | 2021
    2021, 'Targeting lysyl oxidase family meditated matrix cross‐linking as an anti‐stromal therapy in solid tumours', Cancers, 13, pp. 1 - 26, http://dx.doi.org/10.3390/cancers13030491
    Journal articles | 2021
    2021, 'The matrix in cancer', Nature Reviews Cancer, 21, pp. 217 - 238, http://dx.doi.org/10.1038/s41568-020-00329-7
    Journal articles | 2021
    2021, 'Towards engineering heart tissues from bioprinted cardiac spheroids', Biofabrication, 13, http://dx.doi.org/10.1088/1758-5090/ac14ca
    Journal articles | 2020
    Nobis M; Herrmann D; Warren SC; Strathdee D; Cox TR; Anderson KI; Timpson P, 2020, 'Shedding new light on RhoA signalling as a drug target in vivo using a novel RhoA-FRET biosensor mouse', Small GTPases, 11, pp. 240 - 247, http://dx.doi.org/10.1080/21541248.2018.1438024
    Journal articles | 2020
    2020, 'Cancer Metastasis: The Role of the Extracellular Matrix and the Heparan Sulfate Proteoglycan Perlecan', Frontiers in Oncology, 9, http://dx.doi.org/10.3389/fonc.2019.01482
    Journal articles | 2020
    2020, 'Plasma polymerized nanoparticles effectively deliver dual siRNA and drug therapy in vivo', Scientific Reports, 10, http://dx.doi.org/10.1038/s41598-020-69591-x
    Journal articles | 2020
    2020, 'Single-cell analysis reveals diverse stromal subsets associated with immune evasion in triple-negative breast cancer', bioRxiv, http://dx.doi.org/10.1101/2020.06.04.135327
    Journal articles | 2020
    2020, 'Stromal cell diversity associated with immune evasion in human triple-negative breast cancer', EMBO Journal, 39, http://dx.doi.org/10.15252/embj.2019104063
    Journal articles | 2020
    2020, 'The Mini-Organo: A rapid high-throughput 3D coculture organotypic assay for oncology screening and drug development', Cancer Reports, 3, http://dx.doi.org/10.1002/cnr2.1209
    Journal articles | 2020
    2020, 'The Role of the ECM in Lung Cancer Dormancy and Outgrowth', Frontiers in Oncology, 10, http://dx.doi.org/10.3389/fonc.2020.01766
    Journal articles | 2019
    2019, 'CAF Subpopulations: A New Reservoir of Stromal Targets in Pancreatic Cancer', Trends in Cancer, 5, pp. 724 - 741, http://dx.doi.org/10.1016/j.trecan.2019.09.010
    Journal articles | 2019
    2019, 'CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan', Nature Communications, 10, pp. 3637, http://dx.doi.org/10.1038/s41467-019-10968-6
    Journal articles | 2019
    2019, 'LOXL1 is regulated by integrin α11 and promotes non-small cell lung cancer tumorigenicity', Cancers, 11, http://dx.doi.org/10.3390/cancers11050705
    Journal articles | 2019
    2019, 'Meeting report: Metastasis Research Society (MRS) 17th Biennial conference and associated Young Investigator Satellite Meeting (YISM) on cancer metastasis', Clinical and Experimental Metastasis, 36, pp. 119 - 137, http://dx.doi.org/10.1007/s10585-018-09953-y
    Journal articles | 2019
    2019, 'Proteomic Profiling of Human Prostate Cancer-associated Fibroblasts (CAF) Reveals LOXL2-dependent Regulation of the Tumor Microenvironment.', Mol Cell Proteomics, 18, pp. 1410 - 1427, http://dx.doi.org/10.1074/mcp.RA119.001496
    Journal articles | 2019
    2019, 'Proteomic profiling of human prostate cancer-associated fibroblasts (CAF) reveals LOXL2-dependent regulation of the tumor microenvironment', Molecular and Cellular Proteomics, 18, pp. 1410 - 1427, http://dx.doi.org/10.1074/mcp.RA119.001496
    Journal articles | 2019
    2019, 'Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer', Breast Cancer Research, 21, pp. 43, http://dx.doi.org/10.1186/s13058-019-1127-y
    Journal articles | 2019
    2019, 'Targeting the lysyl oxidases in tumour desmoplasia', Biochemical Society Transactions, 47, pp. 1661 - 1678, http://dx.doi.org/10.1042/BST20190098
    Journal articles | 2019
    2019, 'The extracellular matrix as a key regulator of intracellular signalling networks', British Journal of Pharmacology, 176, pp. 82 - 92, http://dx.doi.org/10.1111/bph.14195
    Journal articles | 2019
    2019, 'The importance of developing therapies targeting the biological spectrum of metastatic disease', Clinical and Experimental Metastasis, 36, pp. 305 - 309, http://dx.doi.org/10.1007/s10585-019-09972-3
    Journal articles | 2018
    Cazet AS; Hui MN; Elsworth BL; Wu SZ; Roden D; Chan CL; Skhinas JN; Collot R; Yang J; Harvey K; Johan MZ; Cooper C; Nair R; Herrmann D; McFarland A; Deng N; Ruiz-Borrego M; Rojo F; Trigo JM; Bezares S; Caballero R; Lim E; Timpson P; O’Toole S; Watkins DN; Cox TR; Samuel MS; Martín M; Swarbrick A, 2018, 'Targeting stromal remodeling and cancer stem cell plasticity overcomes chemoresistance in triple negative breast cancer', Nature Communications, 9, http://dx.doi.org/10.1038/s41467-018-05220-6
    Journal articles | 2018
    Cox TR; Erler JT; Rumney RM H, 2018, 'Established Models and New Paradigms for Hypoxia-Driven Cancer-Associated Bone Disease', Calcified Tissue International, 102, pp. 163 - 173, http://dx.doi.org/10.1007/s00223-017-0352-6
    Journal articles | 2018
    Filipe EC; Chitty JL; Cox TR, 2018, 'Charting the unexplored extracellular matrix in cancer', International Journal of Experimental Pathology, 99, pp. 58 - 76, http://dx.doi.org/10.1111/iep.12269
    Journal articles | 2018
    Høye AM; Tolstrup SD; Horton ER; Nicolau M; Frost H; Woo JH; Mauldin JP; Frankel AE; Cox TR; Erler JT, 2018, 'Tumor endothelial marker 8 promotes cancer progression and metastasis', Oncotarget, 9, pp. 30173 - 30188, http://dx.doi.org/10.18632/oncotarget.25734
    Journal articles | 2018
    Skhinas JN; Cox TR, 2018, 'The interplay between extracellular matrix remodelling and kinase signalling in cancer progression and metastasis', Cell Adhesion and Migration, 12, pp. 529 - 537, http://dx.doi.org/10.1080/19336918.2017.1405208
    Journal articles | 2018
    Vennin C; Murphy KJ; Morton JP; Cox TR; Pajic M; Timpson P, 2018, 'Reshaping the Tumor Stroma for Treatment of Pancreatic Cancer', Gastroenterology, 154, pp. 820 - 838, http://dx.doi.org/10.1053/j.gastro.2017.11.280
    Journal articles | 2018
    Warren SC; Nobis M; Magenau A; Mohammed YH; Herrmann D; Moran I; Vennin C; Conway JR W; Mélénec P; Cox TR; Wang Y; Morton JP; Welch HC E; Strathdee D; Anderson KI; Phan TG; Roberts MS; Timpson P, 2018, 'Removing physiological motion from Intravital and clinical functional imaging data', eLife, 7, http://dx.doi.org/10.7554/eLife.35800
    Journal articles | 2018
    Wullkopf L; West AK V; Leijnse N; Cox TR; Madsen CD; Oddershede LB; Erler JT, 2018, 'Cancer cells' ability to mechanically adjust to extracellular matrix stiffness correlates with their invasive potential', Molecular Biology of the Cell, 29, pp. 2378 - 2385, http://dx.doi.org/10.1091/mbc.E18-05-0319
    Journal articles | 2018
    Xia T; Horton ER; Salcini AE; Pocock R; Cox TR; Erler JT, 2018, 'Proteomic Characterization of Caenorhabditis elegans Larval Development', Proteomics, 18, http://dx.doi.org/10.1002/pmic.201700238
    Journal articles | 2018
    2018, 'PO-229 Transient tissue ‘priming’ via FAK inhibition to impair pancreatic ductal adenocarcinoma (PDAC) progression to improve sensitivity to gemcitabine/abraxane', ESMO Open, 3, pp. A316 - A317, http://dx.doi.org/10.1136/esmoopen-2018-eacr25.746
    Journal articles | 2018
    2018, 'Recent advances in understanding the complexities of metastasis', F1000Research, 7, http://dx.doi.org/10.12688/f1000research.15064.2
    Journal articles | 2018
    2018, 'Tailored first-line and second-line CDK4-targeting treatment combinations in mouse models of pancreatic cancer', Gut, 67, pp. 2142 - 2155, http://dx.doi.org/10.1136/gutjnl-2017-315144
    Journal articles | 2017
    Bankaitis K; Borriello L; Cox T; Lynch C; Zijlstra A; Fingleton B; Gužvić M; Anderson R; Neman J, 2017, 'Meeting report: Metastasis Research Society–Chinese Tumor Metastasis Society joint conference on metastasis', Clinical and Experimental Metastasis, 34, pp. 203 - 213, http://dx.doi.org/10.1007/s10585-017-9842-1
    Journal articles | 2017
    Chang J; Lucas MC; Leonte LE; Garcia-Montolio M; Singh LB; Findlay AD; Deodhar M; Foot JS; Jarolimek W; Timpson P; Erler JT; Cox TR, 2017, 'Pre-clinical evaluation of small molecule LOXL2 inhibitors in breast cancer', Oncotarget, 8, pp. 26066 - 26078, http://dx.doi.org/10.18632/oncotarget.15257
    Journal articles | 2017
    Conway JR W; Vennin C; Cazet AS; Herrmann D; Murphy KJ; Warren SC; Wullkopf L; Boulghourjian A; Zaratzian A; Da Silva AM; Pajic M; Morton JP; Cox TR; Timpson P, 2017, 'Three-dimensional organotypic matrices from alternative collagen sources as pre-clinical models for cell biology', Scientific Reports, 7, http://dx.doi.org/10.1038/s41598-017-17177-5
    Journal articles | 2017
    Elyas E; Grimwood A; Erler JT; Robinson SP; Cox TR; Woods D; Clowes P; De Luca R; Marinozzi F; Fromageau J; Bamber JC, 2017, 'Multi-channel optical coherence elastography using relative and absolute shear-wave time of flight', PLoS ONE, 12, http://dx.doi.org/10.1371/journal.pone.0169664
    Journal articles | 2017
    Elyas E; Papaevangelou E; Alles EJ; Erler JT; Cox TR; Robinson SP; Bamber JC, 2017, 'Correlation of ultrasound shear wave elastography with pathological analysis in a xenografic tumour model', Scientific Reports, 7, http://dx.doi.org/10.1038/s41598-017-00144-5
    Journal articles | 2017
    Fingleton B; Lange K; Caldwell B; Bankaitis KV; Kang Y; Yu D; Aguirre-Ghiso J; Cox TR; Erler JT; Gelman IH; Hurst DR; Kato Y; Lynch CC; Price JT; Samant RS; Sleeman J; Stein U; Zijlstra A, 2017, 'Perspective on the interpretation of research and translation to clinical care with therapy-associated metastatic breast cancer progression as an example', Clinical and Experimental Metastasis, 34, pp. 443 - 447, http://dx.doi.org/10.1007/s10585-017-9872-8
    Journal articles | 2017
    Koplev S; Longden J; Ferkinghoff-Borg J; Blicher Bjerregård M; Cox TR; Erler JT; Pedersen JT; Voellmy F; Sommer MO A; Linding R, 2017, 'Dynamic Rearrangement of Cell States Detected by Systematic Screening of Sequential Anticancer Treatments', Cell Reports, 20, pp. 2784 - 2791, http://dx.doi.org/10.1016/j.celrep.2017.08.095
    Journal articles | 2017
    Liu N; Cox TR; Cui W; Adell G; Holmlund B; Ping J; Jarlsfelt I; Erler JT; Sun XF, 2017, 'Nuclear expression of lysyl oxidase enzyme is an independent prognostic factor in rectal cancer patients', Oncotarget, 8, pp. 60015 - 60024, http://dx.doi.org/10.18632/oncotarget.9623
    Journal articles | 2017
    Mayorca-Guiliani AE; Madsen CD; Cox TR; Horton ER; Venning FA; Erler JT, 2017, 'ISDoT: In situ decellularization of tissues for high-resolution imaging and proteomic analysis of native extracellular matrix', Nature Medicine, 23, pp. 890 - 898, http://dx.doi.org/10.1038/nm.4352
    Journal articles | 2017
    Peinado H; Zhang H; Matei IR; Costa-Silva B; Hoshino A; Rodrigues G; Psaila B; Kaplan RN; Bromberg JF; Kang Y; Bissell MJ; Cox TR; Giaccia AJ; Erler JT; Hiratsuka S; Ghajar CM; Lyden D, 2017, 'Pre-metastatic niches: Organ-specific homes for metastases', Nature Reviews Cancer, 17, pp. 302 - 317, http://dx.doi.org/10.1038/nrc.2017.6
    Journal articles | 2017
    Vennin C; Chin VT; Warren SC; Lucas MC; Herrmann D; Magenau A; Melenec P; Walters SN; Del Monte-Nieto G; Conway JR W; Nobis M; Allam AH; McCloy RA; Currey N; Pinese M; Boulghourjian A; Zaratzian A; Adam AA S; Heu C; Nagrial AM; Chou A; Steinmann A; Drury A; Froio D; Giry-Laterriere M; Harris NL E; Phan T; Jain R; Weninger W; McGhee EJ; Whan R; Johns AL; Samra JS; Chantrill L; Gill AJ; Kohonen-Corish M; Harvey RP; Biankin AV; Evans TR J; Anderson KI; Grey ST; Ormandy CJ; Gallego-Ortega D; Wang Y; Samuel MS; Sansom OJ; Burgess A; Cox TR; Morton JP; Pajic M; Timpson P, 2017, 'Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis', Science Translational Medicine, 9, http://dx.doi.org/10.1126/scitranslmed.aai8504
    Journal articles | 2017
    Vennin C; Cox TR; Pajic M; Timpson P, 2017, 'Transient targeting of the pancreatic cancer stroma as a 'finetuned' anti-tumor and anti-metastatic therapy', Oncotarget, 8, pp. 84635 - 84636, http://dx.doi.org/10.18632/oncotarget.21468
    Journal articles | 2017
    2017, 'Nuclear expression of lysyl oxidase enzyme is an independent prognostic factor in rectal cancer patients.', Oncotarget, 8, pp. 60015 - 60024, http://dx.doi.org/10.18632/oncotarget.9623
    Journal articles | 2017
    2017, 'Relative Stiffness Measurements of Cell-embedded Hydrogels by Shear Rheology in vitro.', Bio Protoc, 7, pp. e2101, http://dx.doi.org/10.21769/BioProtoc.2101
    Journal articles | 2017
    2017, 'Relative Stiffness Measurements of Tumour Tissues by Shear Rheology', BIO-PROTOCOL, 7, http://dx.doi.org/10.21769/BioProtoc.2265
    Journal articles | 2016
    Cox TR; Erler JT, 2016, 'Fibrosis and Cancer: Partners in Crime or Opposing Forces?', Trends in Cancer, 2, pp. 279 - 282, http://dx.doi.org/10.1016/j.trecan.2016.05.004
    Journal articles | 2016
    Cox TR; Gartland A; Erler JT, 2016, 'Lysyl oxidase, a targetable secreted molecule involved in cancer metastasis', Cancer Research, 76, pp. 188 - 192, http://dx.doi.org/10.1158/0008-5472.CAN-15-2306
    Journal articles | 2016
    Gartland A; Erler JT; Cox TR, 2016, 'The role of lysyl oxidase, the extracellular matrix and the pre-metastatic niche in bone metastasis', Journal of Bone Oncology, 5, pp. 100 - 103, http://dx.doi.org/10.1016/j.jbo.2016.04.001
    Journal articles | 2015
    Cox TR; Rumney RM H; Schoof EM; Perryman L; Høye AM; Agrawal A; Bird D; Latif NA; Forrest H; Evans HR; Huggins ID; Lang G; Linding R; Gartland A; Erler JT, 2015, 'The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase', Nature, 522, pp. 106 - 110, http://dx.doi.org/10.1038/nature14492
    Journal articles | 2015
    Cox TR; Schoof EM; Gartland A; Erler JT; Linding R, 2015, 'Dataset for the proteomic inventory and quantitative analysis of the breast cancer hypoxic secretome associated with osteotropism', Data in Brief, 5, pp. 621 - 625, http://dx.doi.org/10.1016/j.dib.2015.09.039
    Journal articles | 2015
    Creixell P; Schoof EM; Simpson CD; Longden J; Miller CJ; Lou HJ; Perryman L; Cox TR; Zivanovic N; Palmeri A; Wesolowska-Andersen A; Helmer-Citterich M; Ferkinghoff-Borg J; Itamochi H; Bodenmiller B; Erler JT; Turk BE; Linding R, 2015, 'Kinome-wide Decoding of Network-Attacking Mutations Rewiring Cancer Signaling', Cell, 163, pp. 202 - 217, http://dx.doi.org/10.1016/j.cell.2015.08.056
    Journal articles | 2015
    Madsen CD; Pedersen JT; Venning FA; Singh LB; Moeendarbary E; Charras G; Cox TR; Sahai E; Erler JT, 2015, 'Hypoxia and loss of PHD2 inactivate stromal fibroblasts to decrease tumour stiffness and metastasis', EMBO Reports, 16, pp. 1394 - 1408, http://dx.doi.org/10.15252/embr.201540107
    Journal articles | 2015
    Rodriguez-Teja M; Gronau JH; Breit C; Zhang YZ; Minamidate A; Caley MP; McCarthy A; Cox TR; Erler JT; Gaughan L; Darby S; Robson C; Mauri F; Waxman J; Sturge J, 2015, 'AGE-modified basement membrane cooperates with Endo180 to promote epithelial cell invasiveness and decrease prostate cancer survival', Journal of Pathology, 235, pp. 581 - 592, http://dx.doi.org/10.1002/path.4485
    Journal articles | 2014
    Cox TR; Erler JT, 2014, 'Fibrosis, cancer and the premetastatic niche', Breast Cancer Management, 3, pp. 453 - 455, http://dx.doi.org/10.2217/bmt.14.36
    Journal articles | 2014
    Cox TR; Erler JT, 2014, 'Molecular pathways: Connecting fibrosis and solid tumor metastasis', Clinical Cancer Research, 20, pp. 3637 - 3643, http://dx.doi.org/10.1158/1078-0432.CCR-13-1059
    Journal articles | 2013
    Baker AM; Bird D; Lang G; Cox TR; Erler JT, 2013, 'Lysyl oxidase enzymatic function increases stiffness to drive colorectal cancer progression through FAK', Oncogene, 32, pp. 1863 - 1868, http://dx.doi.org/10.1038/onc.2012.202
    Journal articles | 2013
    Baker AM; Bird D; Welti JC; Gourlaouen M; Lang G; Murray GI; Reynolds AR; Cox TR; Erler JT, 2013, 'Lysyl oxidase plays a critical role in endothelial cell stimulation to drive tumor angiogenesis', Cancer Research, 73, pp. 583 - 594, http://dx.doi.org/10.1158/0008-5472.CAN-12-2447
    Journal articles | 2013
    Chang J; Nicolau MM; Cox TR; Wetterskog D; Martens JW M; E Barker H; Erler JT, 2013, 'LOXL2 induces aberrant acinar morphogenesis via ErbB2 signaling', Breast Cancer Research, 15, http://dx.doi.org/10.1186/bcr3461
    Journal articles | 2013
    Cox TR; Bird D; Baker AM; Barker HE; Ho MW Y; Lang G; Erler JT, 2013, 'LOX-mediated collagen crosslinking is responsible for fibrosis-enhanced metastasis', Cancer Research, 73, pp. 1721 - 1732, http://dx.doi.org/10.1158/0008-5472.CAN-12-2233
    Journal articles | 2013
    Cox TR; Erler JT, 2013, 'Lysyl oxidase in colorectal cancer', American Journal of Physiology - Gastrointestinal and Liver Physiology, 305, http://dx.doi.org/10.1152/ajpgi.00425.2012
    Journal articles | 2013
    R Cox T, 2013, 'The Importance of LOX Family Members on Modulating Cell-ECM Interactions in Carcinogenesis', Journal of Carcinogenesis & Mutagenesis, S13, http://dx.doi.org/10.4172/2157-2518.s13-001
    Journal articles | 2012
    Barker HE; Cox TR; Erler JT, 2012, 'The rationale for targeting the LOX family in cancer', Nature Reviews Cancer, 12, pp. 540 - 552, http://dx.doi.org/10.1038/nrc3319
    Journal articles | 2012
    Cox TR; Erler JT, 2012, 'Network biology and the 3-Dimensional tumor microenvironment: personalizing medicine for the future', Tumor Microenvironment and Therapy, 1, http://dx.doi.org/10.2478/tumor-2012-0002
    Journal articles | 2012
    Cox TR; Gartland A; Erler JT, 2012, 'The pre-metastatic niche: is metastasis random?', Bonekey Rep, 1, pp. 80, http://dx.doi.org/10.1038/bonekey.2012.80
    Journal articles | 2011
    Baker AM; Cox TR; Bird D; Lang G; Murray GI; Sun XF; Southall SM; Wilson JR; Erler JT, 2011, 'The role of lysyl oxidase in SRC-dependent proliferation and metastasis of colorectal cancer', Journal of the National Cancer Institute, 103, pp. 407 - 424, http://dx.doi.org/10.1093/jnci/djq569
    Journal articles | 2011
    Barker HE; Chang J; Cox TR; Lang G; Bird D; Nicolau M; Evans HR; Gartland A; Erler JT, 2011, 'LOXL2-mediated matrix remodeling in metastasis and mammary gland involution', Cancer Research, 71, pp. 1561 - 1572, http://dx.doi.org/10.1158/0008-5472.CAN-10-2868
    Journal articles | 2011
    Cox TR; Erler JT, 2011, 'Remodeling and homeostasis of the extracellular matrix: Implications for fibrotic diseases and cancer', DMM Disease Models and Mechanisms, 4, pp. 165 - 178, http://dx.doi.org/10.1242/dmm.004077
    Journal articles | 2011
    2011, 'Tumour-secreted lox mediates osteolytic bone metastases prior to metastatic tumour cell colonisation', Bone, 48, pp. S21 - S21, http://dx.doi.org/10.1016/j.bone.2010.10.054
    Journal articles | 2010
    Graham HK; Hodson NW; Hoyland JA; Millward-Sadler SJ; Garrod D; Scothern A; Griffiths CE M; Watson RE B; Cox TR; Erler JT; Trafford AW; Sherratt MJ, 2010, 'Tissue section AFM: In situ ultrastructural imaging of native biomolecules', Matrix Biology, 29, pp. 254 - 260, http://dx.doi.org/10.1016/j.matbio.2010.01.008
    Journal articles | 2009
    Erler JT; Bennewith KL; Cox TR; Lang G; Bird D; Koong A; Le QT; Giaccia AJ, 2009, 'Hypoxia-Induced Lysyl Oxidase Is a Critical Mediator of Bone Marrow Cell Recruitment to Form the Premetastatic Niche', Cancer Cell, 15, pp. 35 - 44, http://dx.doi.org/10.1016/j.ccr.2008.11.012
  • Other | 2023
    2023, Data from Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma Determine Response to SLC7A11 Inhibition, , http://dx.doi.org/10.1158/0008-5472.c.6512931.v1
    Other | 2023
    2023, Figure S1 from Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma Determine Response to SLC7A11 Inhibition, , http://dx.doi.org/10.1158/0008-5472.22428180
    Other | 2023
    2023, Figure S1 from Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma Determine Response to SLC7A11 Inhibition, , http://dx.doi.org/10.1158/0008-5472.22428180.v1
    Other | 2023
    2023, Figure S2 from Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma Determine Response to SLC7A11 Inhibition, , http://dx.doi.org/10.1158/0008-5472.22428177
    Other | 2023
    2023, Figure S2 from Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma Determine Response to SLC7A11 Inhibition, , http://dx.doi.org/10.1158/0008-5472.22428177.v1
    Other | 2023
    2023, Figure S3 from Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma Determine Response to SLC7A11 Inhibition, , http://dx.doi.org/10.1158/0008-5472.22428168
    Other | 2023
    2023, Figure S3 from Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma Determine Response to SLC7A11 Inhibition, , http://dx.doi.org/10.1158/0008-5472.22428168.v1
    Other | 2023
    2023, Figure S4 from Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma Determine Response to SLC7A11 Inhibition, , http://dx.doi.org/10.1158/0008-5472.22428165
    Other | 2023
    2023, Figure S4 from Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma Determine Response to SLC7A11 Inhibition, , http://dx.doi.org/10.1158/0008-5472.22428165.v1
    Other | 2023
    2023, Supplementary Table 1 from Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma Determine Response to SLC7A11 Inhibition, , http://dx.doi.org/10.1158/0008-5472.22428162
    Other | 2023
    2023, Supplementary Table 1 from Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma Determine Response to SLC7A11 Inhibition, , http://dx.doi.org/10.1158/0008-5472.22428162.v1
    Other | 2023
    2023, Supplementary Table 2 from Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma Determine Response to SLC7A11 Inhibition, , http://dx.doi.org/10.1158/0008-5472.22428159
    Other | 2023
    2023, Supplementary Table 2 from Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma Determine Response to SLC7A11 Inhibition, , http://dx.doi.org/10.1158/0008-5472.22428159.v1
    Other | 2023
    2023, Supplementary Table 3 from Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma Determine Response to SLC7A11 Inhibition, , http://dx.doi.org/10.1158/0008-5472.22428156
    Other | 2023
    2023, Supplementary Table 3 from Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma Determine Response to SLC7A11 Inhibition, , http://dx.doi.org/10.1158/0008-5472.22428156.v1
    Other | 2023
    2023, Supplementary Table 4 from Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma Determine Response to SLC7A11 Inhibition, , http://dx.doi.org/10.1158/0008-5472.22428153
    Other | 2023
    2023, Supplementary Table 4 from Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma Determine Response to SLC7A11 Inhibition, , http://dx.doi.org/10.1158/0008-5472.22428153.v1
    Preprints | 2022
    2022, Spatial Analysis of the Metastatic Brain Tumor Immune and Extracellular Matrix Microenvironment, , http://dx.doi.org/10.2139/ssrn.4214030
    Preprints | 2022
    2022, Spatial analysis of the metastatic brain tumor immune and extracellular matrix microenvironment, , http://dx.doi.org/10.1101/2022.08.30.505945
    Preprints | 2021
    2021, Micromechanical Characterisation of 3D Bioprinted neural cell models using Brillouin Microscopy, , http://dx.doi.org/10.1101/2021.08.17.456575
    Preprints | 2020
    2020, Cancer-associated fibroblasts in pancreatic ductal adenocarcinoma determine response to SLC7A11 inhibition, , http://dx.doi.org/10.1101/2020.07.12.199638
    Conference Abstracts | 2018
    2018, 'Targeting the Hedgehog signalling pathway in triple negative breast cancer.', in JOURNAL OF CLINICAL ONCOLOGY, AMER SOC CLINICAL ONCOLOGY, Vol. 36, http://dx.doi.org/10.1200/JCO.2018.36.15_suppl.e24216
    Preprints | 2017
    2017, Targeting stromal remodeling and cancer stem cell plasticity to overcome chemoresistance in triple negative breast cancer, , http://dx.doi.org/10.1101/215954
    Conference Papers | 2016
    2016, 'Abstract 5012: Nuclear expression of lysyl oxidase enzyme is an independent prognostic factor in rectal cancer patients', in Cancer Research, American Association for Cancer Research (AACR), pp. 5012 - 5012, presented at Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA, http://dx.doi.org/10.1158/1538-7445.am2016-5012
    Conference Papers | 2016
    2016, 'Abstract B17: Disrupting tumor growth through targeting TEM8', in Cancer Research, American Association for Cancer Research (AACR), pp. B17 - B17, presented at Abstracts: AACR Special Conference: The Function of Tumor Microenvironment in Cancer Progression; January 7-10, 2016; San Diego, CA, http://dx.doi.org/10.1158/1538-7445.tme16-b17
    Preprints |
    Breast Cancer-Secreted Laminin γ2 Promotes Metastatic Progression Through Attraction of Blood Vessels, , http://dx.doi.org/10.2139/ssrn.3631394
    Preprints |
    Epithelial-Mesenchymal Transition Inversely Associates With Immune Activity in Breast Cancer Tumour Immune Microenvironment, , http://dx.doi.org/10.2139/ssrn.3811836
    Preprints |
    Single Cell Transcriptomics Reveals Involution Mimicry During the Specification of the Basal Breast Cancer Subtype, , http://dx.doi.org/10.2139/ssrn.3634808

The labs creative research program integrates matrix biology with precision oncology, aligning with Garvan’s strategic vision to make fundamental advances in the understanding, treatment and prevention of human disease, in this case, personalised stromal targeting in solid tumours.

The goals of the team are to develop, deploy and repurpose anti-stromal/anti-fibrotic therapies for cancer treatment, and maximise the effectiveness of pre-clinical cancer models through the following parallel, complementary research streams:

(1) Expanding the repertoire of anti-cancer therapeutic targets to include matrix molecules and their effectors, critical component of all solid tumours, and drive forward our already established pipeline of anti-ECM drugs.

(2) Continue to develop and utilise powerful, state-of-the-art, physiologically relevant in vitro and in vivo 3D models that include native ECM to assay and streamline the evaluation of novel and existing therapies.

(3) Reshape the way we view the matrix, as an active contributor to cancer, not just a passive bystander, and leverage this to better stratify cancer patients for personalised stromal targeting in solid tumours.

My Research Supervision

B.Sc. placement

Honours

Ph.D

Visiting International Students