Associate Professor Thomas Robert Cox
Conjoint Associate Professor

Associate Professor Thomas Robert Cox

Medicine & Health
St Vincent's Clinical School

The Matrix and Metastasis Lab is based at the Garvan Institute of Medical Research Kinghorn Cancer Centre in Sydney, Australia.

Research Interests:
Our research focuses on how the extracellular matrix (ECM) and ECM remodelling influences cancer progression, therapy response, and metastasis in solid tumours

Broad Research Areas:
Cancer, Cancer Cell Biology, Biochemistry, Proteomics

Society Memberships & Professional Activities:
Metastasis Research Society (MRS), Matrix Biology Society of Australia & New Zealand (MBSANZ)[Vice-President], British Society for Matrix Biology (BSMB), American Association for Cancer Research (AACR), British Association for Cancer Research (BACR)

Specific Research Keywords:
Extracellular Matrix, Cancer Metastasis, Targetted Therapies,

Phone
02 9355 5825
Location
Garvan Institute of Medial Research The Kinghorn Cancer Centre 384 Victoria St Darlinghurst NSW 2010

Publications

  • Book Chapters | 2020
    Papanicolaou M; Cox TR, 2020, 'Extracellular Matrix (ECM)', in Encyclopedia of Molecular Pharmacology, Springer International Publishing, pp. 1 - 8, http://dx.doi.org/10.1007/978-3-030-21573-6_5691-1
    Book Chapters | 2017
    El Rayes T; Gao D; Altorki NK; Cox TR; Erler JT; Mittal V, 2017, 'Regulation of tumor progression and metastasis by bone marrow-derived microenvironments', in Biomarkers of the Tumor Microenvironment: Basic Studies and Practical Applications, Springer, pp. 303 - 328, http://dx.doi.org/10.1007/978-3-319-39147-2_13
    Book Chapters | 2013
    Cox TR; Erler JT, 2013, 'Remodelling of the extracellular matrix: Implications for cancer', in Cell and Molecular Biology of Breast Cancer, pp. 65 - 90, http://dx.doi.org/10.1007/978-1-62703-634-4_4
  • Journal articles | 2021
    Lakis V; Lawlor RT; Newell F; Patch AM; Mafficini A; Sadanandam A; Koufariotis LT; Johnston RL; Leonard C; Wood S; Rusev B; Corbo V; Luchini C; Cingarlini S; Landoni L; Salvia R; Milella M; Chang D; Bailey P; Jamieson NB; Duthie F; Gingras MC; Muzny DM; Wheeler DA; Gibbs RA; Milione M; Chantrill LA; Timpson P; Chou A; Pajic M; Murphy A; Dwarte T; Hermann D; Vennin C; Cox TR; Pereira B; Ritchie S; Reed DA; Chambers CR; Metcalf X; Nobis M; Mukhopadhyay P; Addala V; Kazakoff S; Holmes O; Xu Q; Hofmann O; Samra JS; Pavlakis N; Arena J; High HA; Asghari R; Merrett ND; Pavey D; Das A; Cosman PH; Ismail K; O’Connnor C; Stoita A; Williams D; Spigellman A; Lam VW; McLeod D; Kirk J; Kench JG; Grimison P; Sandroussi C; Goodwin A; Mead RS; Tucker K; Andrews L; Texler M; Forest C; Ballal M; Fletcher DR; Zeps N; Nguyen NQ; Ruszkiewicz AR; Worthley C; Chen J; Brooke-Smith ME; Papangelis V; Clouston AD; Barbour AP; O’Rourke TJ; Fawcett JW; Slater K; Hatzifotis M; Hodgkinson P; Nikfarjam M; Eshleman JR; Hruban RH; Wolfgang CL; Dixon J; Scardoni M; Bassi C; Grimaldi S; Cantù C; Bonizzato G; Bersani S, 2021, 'DNA methylation patterns identify subgroups of pancreatic neuroendocrine tumors with clinical association', Communications Biology, vol. 4, http://dx.doi.org/10.1038/s42003-020-01469-0
    Journal articles | 2021
    Sharbeen G; McCarroll JA; Akerman A; Kopecky C; Youkhana J; Kokkinos J; Holst J; Boyer C; Erkan M; Goldstein D; Timpson P; Cox TR; Pereira BA; Chitty JL; Fey SK; Najumudeen AK; Campbell AD; Sansom OJ; Ignacio RMC; Naim S; Liu J; Russia N; Lee J; Chou A; Johns A; Gill AJ; Gonzales-Aloy E; Gebski V; Guan YF; Pajic M; Turner N; Apte MV; Davis TP; Morton JP; Haghighi KS; Kasparian J; McLean BJ; Setargew YF; Phillips PA, 2021, 'Cancer-associated fibroblasts in pancreatic ductal adenocarcinoma determine response to slc7a11 inhibition', Cancer Research, vol. 81, pp. 3461 - 3479, http://dx.doi.org/10.1158/0008-5472.CAN-20-2496
    Journal articles | 2021
    Valdés-Mora F; Salomon R; Gloss BS; Law AMK; Venhuizen J; Castillo L; Murphy KJ; Magenau A; Papanicolaou M; Rodriguez de la Fuente L; Roden DL; Colino-Sanguino Y; Kikhtyak Z; Farbehi N; Conway JRW; Sikta N; Oakes SR; Cox TR; O'Donoghue SI; Timpson P; Ormandy CJ; Gallego-Ortega D, 2021, 'Single-cell transcriptomics reveals involution mimicry during the specification of the basal breast cancer subtype', Cell Reports, vol. 35, http://dx.doi.org/10.1016/j.celrep.2021.108945
    Journal articles | 2021
    Cox TR, 2021, 'The matrix in cancer', Nature Reviews Cancer, vol. 21, pp. 217 - 238, http://dx.doi.org/10.1038/s41568-020-00329-7
    Journal articles | 2021
    Polonchuk L; Surija L; Lee MH; Sharma P; Ming CLC; Richter F; Ben-Sefer E; Rad MA; Sarmast HMS; Al Shamery W; Tran HA; Vettori L; Haeusermann F; Filipe EC; Rnjak-Kovacina J; Cox T; Tipper J; Kabakova I; Gentile C, 2021, 'Towards engineering heart tissues from bioprinted cardiac spheroids', Biofabrication, vol. 13, http://dx.doi.org/10.1088/1758-5090/ac14ca
    Journal articles | 2021
    Guo G; Papanicolaou M; Demarais NJ; Wang Z; Schey KL; Timpson P; Cox TR; Grey AC, 2021, 'Automated annotation and visualisation of high-resolution spatial proteomic mass spectrometry imaging data using HIT-MAP', Nature Communications, vol. 12, pp. 3241, http://dx.doi.org/10.1038/s41467-021-23461-w
    Book Chapters | 2021
    Filipe EC; Parker AL; Cadell AL; Major G; Croucher DR; Cox TR, 2021, 'In Vitro 3D Models of Tunable Stiffness', in Methods in Molecular Biology, United States, pp. 27 - 42, http://dx.doi.org/10.1007/978-1-0716-1350-4_3
    Journal articles | 2021
    Setargew YFI; Wyllie K; Grant RD; Chitty JL; Cox TR, 2021, 'Targeting lysyl oxidase family meditated matrix cross‐linking as an anti‐stromal therapy in solid tumours', Cancers, vol. 13, pp. 1 - 26, http://dx.doi.org/10.3390/cancers13030491
    Journal articles | 2021
    Holliday H; Roden D; Junankar S; Wu SZ; Baker LA; Krisp C; Chan CL; McFarland A; Skhinas JN; Cox TR; Pal B; Huntington ND; Ormandy CJ; Carroll JS; Visvader J; Molloy MP; Swarbrick A, 2021, 'Inhibitor of Differentiation 4 (ID4) represses mammary myoepithelial differentiation via inhibition of HEB', iScience, vol. 24, pp. 102072 - 102072, http://dx.doi.org/10.1016/j.isci.2021.102072
    Journal articles | 2020
    Wu SZ; Roden DL; Wang C; Holliday H; Harvey K; Cazet AS; Murphy KJ; Pereira B; Al-Eryani G; Bartonicek N; Hou R; Torpy JR; Junankar S; Chan CL; Lam CE; Hui MN; Gluch L; Beith J; Parker A; Robbins E; Segara D; Mak C; Cooper C; Warrier S; Forrest A; Powell J; O'Toole S; Cox TR; Timpson P; Lim E; Liu XS; Swarbrick A, 2020, 'Stromal cell diversity associated with immune evasion in human triple-negative breast cancer', EMBO Journal, vol. 39, http://dx.doi.org/10.15252/embj.2019104063
    Journal articles | 2020
    Nobis M; Herrmann D; Warren SC; Strathdee D; Cox TR; Anderson KI; Timpson P, 2020, 'Shedding new light on RhoA signalling as a drug target in vivo using a novel RhoA-FRET biosensor mouse', Small GTPases, vol. 11, pp. 240 - 247, http://dx.doi.org/10.1080/21541248.2018.1438024
    Journal articles | 2020
    Chitty JL; Skhinas JN; Filipe EC; Wang S; Cupello CR; Grant RD; Yam M; Papanicolaou M; Major G; Zaratzian A; Da Silva AM; Tayao M; Vennin C; Timpson P; Madsen CD; Cox TR, 2020, 'The Mini-Organo: A rapid high-throughput 3D coculture organotypic assay for oncology screening and drug development', Cancer Reports, vol. 3, http://dx.doi.org/10.1002/cnr2.1209
    Journal articles | 2020
    Michael P; Lam YT; Filipe EC; Tan RP; Chan AHP; Lee BSL; Feng N; Hung J; Cox TR; Santos M; Wise SG, 2020, 'Plasma polymerized nanoparticles effectively deliver dual siRNA and drug therapy in vivo', Scientific Reports, vol. 10, http://dx.doi.org/10.1038/s41598-020-69591-x
    Journal articles | 2020
    Wu S; Roden D; Wang C; Holliday H; Harvey K; Cazet A; Murphy K; Pereira B; Al-Eryani G; Bartonicek N; Hou R; Torpy J; Junankar S; Chan C-L; Lam E; Hui M; Gluch L; Beith J; Parker A; Robbins E; Segara D; Mak C; Cooper C; Warrier S; Forrest A; Powell J; O’Toole S; Cox T; Timpson P; Lim E; Liu S; Swarbrick A, 2020, 'Single-cell analysis reveals diverse stromal subsets associated with immune evasion in triple-negative breast cancer', bioRxiv, http://dx.doi.org/10.1101/2020.06.04.135327
    Journal articles | 2020
    Elgundi Z; Papanicolaou M; Major G; Cox TR; Melrose J; Whitelock JM; Farrugia BL, 2020, 'Cancer Metastasis: The Role of the Extracellular Matrix and the Heparan Sulfate Proteoglycan Perlecan', Frontiers in Oncology, vol. 9, http://dx.doi.org/10.3389/fonc.2019.01482
    Journal articles | 2020
    Parker AL; Cox TR, 2020, 'The Role of the ECM in Lung Cancer Dormancy and Outgrowth', Frontiers in Oncology, vol. 10, http://dx.doi.org/10.3389/fonc.2020.01766
    Journal articles | 2019
    Hastings JF; Skhinas JN; Fey D; Croucher DR; Cox TR, 2019, 'The extracellular matrix as a key regulator of intracellular signalling networks', British Journal of Pharmacology, vol. 176, pp. 82 - 92, http://dx.doi.org/10.1111/bph.14195
    Journal articles | 2019
    Vennin C; Mélénec P; Rouet R; Nobis M; Cazet AS; Murphy KJ; Herrmann D; Reed DA; Lucas MC; Warren SC; Elgundi Z; Pinese M; Kalna G; Roden D; Samuel M; Zaratzian A; Grey ST; Da Silva A; Leung W; Johns AL; Chantrill LA; Chou A; Steinmann A; Arshi M; Dwarte T; Froio D; Pereira B; Ritchie S; Chambers CR; Metcalf X; Waddell N; Pearson JV; Patch AM; Nones K; Newell F; Mukhopadhyay P; Addala V; Kazakoff S; Holmes O; Leonard C; Wood S; Grimmond SM; Hofmann O; Christ A; Bruxner T; Samra JS; Pavlakis N; High HA; Asghari R; Merrett ND; Pavey D; Das A; Cosman PH; Ismail K; O’Connnor C; Stoita A; Williams D; Spigellman A; Lam VW; McLeod D; Kirk J; Kench JG; Grimison P; Cooper CL; Sandroussi C; Goodwin A; Mead RS; Tucker K; Andrews L; Texler M; Forest C; Epari KP; Ballal M; Fletcher DR; Mukhedkar S; Zeps N; Beilin M; Feeney K; Nguyen NQ; Ruszkiewicz AR; Worthley C; Chen J; Brooke-Smith ME; Papangelis V; Clouston AD; Barbour AP; O’Rourke TJ; Fawcett JW; Slater K; Hatzifotis M; Hodgkinson P; Nikfarjam M; Eshleman JR; Hruban RH; Wolfgang CL; Lawlor RT; Beghelli S; Corbo V; Scardoni M; Bassi C, 2019, 'CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan', Nature Communications, vol. 10, pp. 3637, http://dx.doi.org/10.1038/s41467-019-10968-6
    Journal articles | 2019
    Nguyen EV; Pereira BA; Lawrence MG; Ma X; Rebello RJ; Chan H; Niranjan B; Wu Y; Ellem S; Guan X; Wu J; Skhinas JN; Cox TR; Risbridger GP; Taylor RA; Lister NL; Daly RJ, 2019, 'Proteomic profiling of human prostate cancer-associated fibroblasts (CAF) reveals LOXL2-dependent regulation of the tumor microenvironment', Molecular and Cellular Proteomics, vol. 18, pp. 1410 - 1427, http://dx.doi.org/10.1074/mcp.RA119.001496
    Journal articles | 2019
    Pereira BA; Vennin C; Papanicolaou M; Chambers CR; Herrmann D; Morton JP; Cox TR; Timpson P, 2019, 'CAF Subpopulations: A New Reservoir of Stromal Targets in Pancreatic Cancer', Trends in Cancer, vol. 5, pp. 724 - 741, http://dx.doi.org/10.1016/j.trecan.2019.09.010
    Journal articles | 2019
    Kennedy SP; Han JZR; Portman N; Nobis M; Hastings JF; Murphy KJ; Latham SL; Cadell AL; Miladinovic D; Marriott GR; O'Donnell YEI; Shearer RF; Williams JT; Munoz AG; Cox TR; Watkins DN; Saunders DN; Timpson P; Lim E; Kolch W; Croucher DR, 2019, 'Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer', Breast Cancer Research, vol. 21, pp. 43, http://dx.doi.org/10.1186/s13058-019-1127-y
    Journal articles | 2019
    Chitty JL; Setargew YFI; Cox TR, 2019, 'Targeting the lysyl oxidases in tumour desmoplasia', Biochemical Society Transactions, vol. 47, pp. 1661 - 1678, http://dx.doi.org/10.1042/BST20190098
    Journal articles | 2019
    Zeltz C; Pasko E; Cox TR; Navab R; Tsao MS, 2019, 'LOXL1 is regulated by integrin α11 and promotes non-small cell lung cancer tumorigenicity', Cancers, vol. 11, http://dx.doi.org/10.3390/cancers11050705
    Journal articles | 2019
    Zijlstra A; Von Lersner A; Yu D; Borrello L; Oudin M; Kang Y; Sahai E; Fingleton B; Stein U; Cox TR; Price JT; Kato Y; Welm AL; Aguirre-Ghiso JA, 2019, 'The importance of developing therapies targeting the biological spectrum of metastatic disease', Clinical and Experimental Metastasis, vol. 36, pp. 305 - 309, http://dx.doi.org/10.1007/s10585-019-09972-3
    Journal articles | 2019
    Beadnell T; Borriello L; Christenson J; Fornetti J; Guldner I; Hanna A; Kyjacova L; Marinak-Whately K; de Melo Martins PC; Rotinen M; te Boekhorst V; Cox TR, 2019, 'Meeting report: Metastasis Research Society (MRS) 17th Biennial conference and associated Young Investigator Satellite Meeting (YISM) on cancer metastasis', Clinical and Experimental Metastasis, vol. 36, pp. 119 - 137, http://dx.doi.org/10.1007/s10585-018-09953-y
    Journal articles | 2019
    Nguyen EV; Pereira BA; Lawrence MG; Ma X; Rebello RJ; Chan H; Niranjan B; Wu Y; Ellem S; Guan X; Wu J; Skhinas JN; Cox TR; Risbridger GP; Taylor RA; Lister NL; Daly RJ, 2019, 'Proteomic Profiling of Human Prostate Cancer-associated Fibroblasts (CAF) Reveals LOXL2-dependent Regulation of the Tumor Microenvironment.', Mol Cell Proteomics, vol. 18, pp. 1410 - 1427, http://dx.doi.org/10.1074/mcp.RA119.001496
    Journal articles | 2018
    Høye AM; Tolstrup SD; Horton ER; Nicolau M; Frost H; Woo JH; Mauldin JP; Frankel AE; Cox TR; Erler JT, 2018, 'Tumor endothelial marker 8 promotes cancer progression and metastasis', Oncotarget, vol. 9, pp. 30173 - 30188, http://dx.doi.org/10.18632/oncotarget.25734
    Journal articles | 2018
    Filipe EC; Chitty JL; Cox TR, 2018, 'Charting the unexplored extracellular matrix in cancer', International Journal of Experimental Pathology, vol. 99, pp. 58 - 76, http://dx.doi.org/10.1111/iep.12269
    Journal articles | 2018
    Xia T; Horton ER; Salcini AE; Pocock R; Cox TR; Erler JT, 2018, 'Proteomic Characterization of Caenorhabditis elegans Larval Development', Proteomics, vol. 18, http://dx.doi.org/10.1002/pmic.201700238
    Journal articles | 2018
    Skhinas JN; Cox TR, 2018, 'The interplay between extracellular matrix remodelling and kinase signalling in cancer progression and metastasis', Cell Adhesion and Migration, vol. 12, pp. 529 - 537, http://dx.doi.org/10.1080/19336918.2017.1405208
    Journal articles | 2018
    Cox TR; Erler JT; Rumney RMH, 2018, 'Established Models and New Paradigms for Hypoxia-Driven Cancer-Associated Bone Disease', Calcified Tissue International, vol. 102, pp. 163 - 173, http://dx.doi.org/10.1007/s00223-017-0352-6
    Journal articles | 2018
    Wullkopf L; West AKV; Leijnse N; Cox TR; Madsen CD; Oddershede LB; Erler JT, 2018, 'Cancer cells' ability to mechanically adjust to extracellular matrix stiffness correlates with their invasive potential', Molecular Biology of the Cell, vol. 29, pp. 2378 - 2385, http://dx.doi.org/10.1091/mbc.E18-05-0319
    Journal articles | 2018
    Chou A; Froio D; Nagrial AM; Parkin A; Murphy KJ; Chin VT; Wohl D; Steinmann A; Stark R; Drury A; Walters SN; Vennin C; Burgess A; Pinese M; Chantrill LA; Cowley MJ; Molloy TJ; Waddell N; Johns A; Grimmond SM; Chang DK; Biankin AV; Sansom OJ; Morton JP; Grey ST; Cox TR; Turchini J; Samra J; Clarke SJ; Timpson P; Gill AJ; Pajic M, 2018, 'Tailored first-line and second-line CDK4-targeting treatment combinations in mouse models of pancreatic cancer', Gut, vol. 67, pp. 2142 - 2155, http://dx.doi.org/10.1136/gutjnl-2017-315144
    Journal articles | 2018
    Chitty JL; Filipe EC; Lucas MC; Herrmann D; Cox TR; Timpson P, 2018, 'Recent advances in understanding the complexities of metastasis', F1000Research, vol. 7, http://dx.doi.org/10.12688/f1000research.15064.2
    Journal articles | 2018
    Cazet AS; Hui MN; Elsworth BL; Wu SZ; Roden D; Chan CL; Skhinas JN; Collot R; Yang J; Harvey K; Johan MZ; Cooper C; Nair R; Herrmann D; McFarland A; Deng N; Ruiz-Borrego M; Rojo F; Trigo JM; Bezares S; Caballero R; Lim E; Timpson P; O’Toole S; Watkins DN; Cox TR; Samuel MS; Martín M; Swarbrick A, 2018, 'Targeting stromal remodeling and cancer stem cell plasticity overcomes chemoresistance in triple negative breast cancer', Nature Communications, vol. 9, http://dx.doi.org/10.1038/s41467-018-05220-6
    Journal articles | 2018
    Vennin C; Murphy KJ; Morton JP; Cox TR; Pajic M; Timpson P, 2018, 'Reshaping the Tumor Stroma for Treatment of Pancreatic Cancer', Gastroenterology, vol. 154, pp. 820 - 838, http://dx.doi.org/10.1053/j.gastro.2017.11.280
    Journal articles | 2018
    Warren SC; Nobis M; Magenau A; Mohammed YH; Herrmann D; Moran I; Vennin C; Conway JRW; Mélénec P; Cox TR; Wang Y; Morton JP; Welch HCE; Strathdee D; Anderson KI; Phan TG; Roberts MS; Timpson P, 2018, 'Removing physiological motion from Intravital and clinical functional imaging data', eLife, vol. 7, http://dx.doi.org/10.7554/eLife.35800
    Journal articles | 2018
    Murphy K; Vennin C; Cox T; Wang Y; Morton J; Sansom O; Pajic M; Herrmann D; Timpson P, 2018, 'PO-229 Transient tissue ‘priming’ via FAK inhibition to impair pancreatic ductal adenocarcinoma (PDAC) progression to improve sensitivity to gemcitabine/abraxane', ESMO Open, vol. 3, pp. A316 - A317, http://dx.doi.org/10.1136/esmoopen-2018-eacr25.746
    Journal articles | 2017
    Elyas E; Papaevangelou E; Alles EJ; Erler JT; Cox TR; Robinson SP; Bamber JC, 2017, 'Correlation of ultrasound shear wave elastography with pathological analysis in a xenografic tumour model', Scientific Reports, vol. 7, http://dx.doi.org/10.1038/s41598-017-00144-5
    Journal articles | 2017
    Elyas E; Grimwood A; Erler JT; Robinson SP; Cox TR; Woods D; Clowes P; De Luca R; Marinozzi F; Fromageau J; Bamber JC, 2017, 'Multi-channel optical coherence elastography using relative and absolute shear-wave time of flight', PLoS ONE, vol. 12, http://dx.doi.org/10.1371/journal.pone.0169664
    Journal articles | 2017
    Liu N; Cox TR; Cui W; Adell G; Holmlund B; Ping J; Jarlsfelt I; Erler JT; Sun XF, 2017, 'Nuclear expression of lysyl oxidase enzyme is an independent prognostic factor in rectal cancer patients', Oncotarget, vol. 8, pp. 60015 - 60024, http://dx.doi.org/10.18632/oncotarget.9623
    Journal articles | 2017
    Koplev S; Longden J; Ferkinghoff-Borg J; Blicher Bjerregård M; Cox TR; Erler JT; Pedersen JT; Voellmy F; Sommer MOA; Linding R, 2017, 'Dynamic Rearrangement of Cell States Detected by Systematic Screening of Sequential Anticancer Treatments', Cell Reports, vol. 20, pp. 2784 - 2791, http://dx.doi.org/10.1016/j.celrep.2017.08.095
    Journal articles | 2017
    Fingleton B; Lange K; Caldwell B; Bankaitis KV; Kang Y; Yu D; Aguirre-Ghiso J; Cox TR; Erler JT; Gelman IH; Hurst DR; Kato Y; Lynch CC; Price JT; Samant RS; Sleeman J; Stein U; Zijlstra A, 2017, 'Perspective on the interpretation of research and translation to clinical care with therapy-associated metastatic breast cancer progression as an example', Clinical and Experimental Metastasis, vol. 34, pp. 443 - 447, http://dx.doi.org/10.1007/s10585-017-9872-8
    Journal articles | 2017
    Peinado H; Zhang H; Matei IR; Costa-Silva B; Hoshino A; Rodrigues G; Psaila B; Kaplan RN; Bromberg JF; Kang Y; Bissell MJ; Cox TR; Giaccia AJ; Erler JT; Hiratsuka S; Ghajar CM; Lyden D, 2017, 'Pre-metastatic niches: Organ-specific homes for metastases', Nature Reviews Cancer, vol. 17, pp. 302 - 317, http://dx.doi.org/10.1038/nrc.2017.6
    Journal articles | 2017
    Chang J; Lucas MC; Leonte LE; Garcia-Montolio M; Singh LB; Findlay AD; Deodhar M; Foot JS; Jarolimek W; Timpson P; Erler JT; Cox TR, 2017, 'Pre-clinical evaluation of small molecule LOXL2 inhibitors in breast cancer', Oncotarget, vol. 8, pp. 26066 - 26078, http://dx.doi.org/10.18632/oncotarget.15257
    Journal articles | 2017
    Vennin C; Cox TR; Pajic M; Timpson P, 2017, 'Transient targeting of the pancreatic cancer stroma as a 'finetuned' anti-tumor and anti-metastatic therapy', Oncotarget, vol. 8, pp. 84635 - 84636, http://dx.doi.org/10.18632/oncotarget.21468
    Journal articles | 2017
    Conway JRW; Vennin C; Cazet AS; Herrmann D; Murphy KJ; Warren SC; Wullkopf L; Boulghourjian A; Zaratzian A; Da Silva AM; Pajic M; Morton JP; Cox TR; Timpson P, 2017, 'Three-dimensional organotypic matrices from alternative collagen sources as pre-clinical models for cell biology', Scientific Reports, vol. 7, http://dx.doi.org/10.1038/s41598-017-17177-5
    Journal articles | 2017
    Vennin C; Chin VT; Warren SC; Lucas MC; Herrmann D; Magenau A; Melenec P; Walters SN; Del Monte-Nieto G; Conway JRW; Nobis M; Allam AH; McCloy RA; Currey N; Pinese M; Boulghourjian A; Zaratzian A; Adam AAS; Heu C; Nagrial AM; Chou A; Steinmann A; Drury A; Froio D; Giry-Laterriere M; Harris NLE; Phan T; Jain R; Weninger W; McGhee EJ; Whan R; Johns AL; Samra JS; Chantrill L; Gill AJ; Kohonen-Corish M; Harvey RP; Biankin AV; Evans TRJ; Anderson KI; Grey ST; Ormandy CJ; Gallego-Ortega D; Wang Y; Samuel MS; Sansom OJ; Burgess A; Cox TR; Morton JP; Pajic M; Timpson P, 2017, 'Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis', Science Translational Medicine, vol. 9, http://dx.doi.org/10.1126/scitranslmed.aai8504
    Journal articles | 2017
    Mayorca-Guiliani AE; Madsen CD; Cox TR; Horton ER; Venning FA; Erler JT, 2017, 'ISDoT: In situ decellularization of tissues for high-resolution imaging and proteomic analysis of native extracellular matrix', Nature Medicine, vol. 23, pp. 890 - 898, http://dx.doi.org/10.1038/nm.4352
    Journal articles | 2017
    Bankaitis K; Borriello L; Cox T; Lynch C; Zijlstra A; Fingleton B; Gužvić M; Anderson R; Neman J, 2017, 'Meeting report: Metastasis Research Society–Chinese Tumor Metastasis Society joint conference on metastasis', Clinical and Experimental Metastasis, vol. 34, pp. 203 - 213, http://dx.doi.org/10.1007/s10585-017-9842-1
    Journal articles | 2017
    Liu N; Cox TR; Cui W; Adell G; Holmlund B; Ping J; Jarlsfelt I; Erler JT; Sun X-F, 2017, 'Nuclear expression of lysyl oxidase enzyme is an independent prognostic factor in rectal cancer patients.', Oncotarget, vol. 8, pp. 60015 - 60024, http://dx.doi.org/10.18632/oncotarget.9623
    Journal articles | 2017
    Madsen CD; Cox TR, 2017, 'Relative Stiffness Measurements of Tumour Tissues by Shear Rheology', BIO-PROTOCOL, vol. 7, http://dx.doi.org/10.21769/BioProtoc.2265
    Journal articles | 2017
    Cox TR; Madsen CD, 2017, 'Relative Stiffness Measurements of Cell-embedded Hydrogels by Shear Rheology in vitro.', Bio Protoc, vol. 7, pp. e2101, http://dx.doi.org/10.21769/BioProtoc.2101
    Journal articles | 2016
    Cox TR; Gartland A; Erler JT, 2016, 'Lysyl oxidase, a targetable secreted molecule involved in cancer metastasis', Cancer Research, vol. 76, pp. 188 - 192, http://dx.doi.org/10.1158/0008-5472.CAN-15-2306
    Journal articles | 2016
    Gartland A; Erler JT; Cox TR, 2016, 'The role of lysyl oxidase, the extracellular matrix and the pre-metastatic niche in bone metastasis', Journal of Bone Oncology, vol. 5, pp. 100 - 103, http://dx.doi.org/10.1016/j.jbo.2016.04.001
    Journal articles | 2016
    Cox TR; Erler JT, 2016, 'Fibrosis and Cancer: Partners in Crime or Opposing Forces?', Trends in Cancer, vol. 2, pp. 279 - 282, http://dx.doi.org/10.1016/j.trecan.2016.05.004
    Journal articles | 2015
    Madsen CD; Pedersen JT; Venning FA; Singh LB; Moeendarbary E; Charras G; Cox TR; Sahai E; Erler JT, 2015, 'Hypoxia and loss of PHD2 inactivate stromal fibroblasts to decrease tumour stiffness and metastasis', EMBO Reports, vol. 16, pp. 1394 - 1408, http://dx.doi.org/10.15252/embr.201540107
    Journal articles | 2015
    Cox TR; Rumney RMH; Schoof EM; Perryman L; Høye AM; Agrawal A; Bird D; Latif NA; Forrest H; Evans HR; Huggins ID; Lang G; Linding R; Gartland A; Erler JT, 2015, 'The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase', Nature, vol. 522, pp. 106 - 110, http://dx.doi.org/10.1038/nature14492
    Journal articles | 2015
    Creixell P; Schoof EM; Simpson CD; Longden J; Miller CJ; Lou HJ; Perryman L; Cox TR; Zivanovic N; Palmeri A; Wesolowska-Andersen A; Helmer-Citterich M; Ferkinghoff-Borg J; Itamochi H; Bodenmiller B; Erler JT; Turk BE; Linding R, 2015, 'Kinome-wide Decoding of Network-Attacking Mutations Rewiring Cancer Signaling', Cell, vol. 163, pp. 202 - 217, http://dx.doi.org/10.1016/j.cell.2015.08.056
    Journal articles | 2015
    Rodriguez-Teja M; Gronau JH; Breit C; Zhang YZ; Minamidate A; Caley MP; McCarthy A; Cox TR; Erler JT; Gaughan L; Darby S; Robson C; Mauri F; Waxman J; Sturge J, 2015, 'AGE-modified basement membrane cooperates with Endo180 to promote epithelial cell invasiveness and decrease prostate cancer survival', Journal of Pathology, vol. 235, pp. 581 - 592, http://dx.doi.org/10.1002/path.4485
    Journal articles | 2015
    Cox TR; Schoof EM; Gartland A; Erler JT; Linding R, 2015, 'Dataset for the proteomic inventory and quantitative analysis of the breast cancer hypoxic secretome associated with osteotropism', Data in Brief, vol. 5, pp. 621 - 625, http://dx.doi.org/10.1016/j.dib.2015.09.039
    Journal articles | 2014
    Cox TR; Erler JT, 2014, 'Molecular pathways: Connecting fibrosis and solid tumor metastasis', Clinical Cancer Research, vol. 20, pp. 3637 - 3643, http://dx.doi.org/10.1158/1078-0432.CCR-13-1059
    Journal articles | 2014
    Cox TR; Erler JT, 2014, 'Fibrosis, cancer and the premetastatic niche', Breast Cancer Management, vol. 3, pp. 453 - 455, http://dx.doi.org/10.2217/bmt.14.36
    Journal articles | 2013
    Baker AM; Bird D; Welti JC; Gourlaouen M; Lang G; Murray GI; Reynolds AR; Cox TR; Erler JT, 2013, 'Lysyl oxidase plays a critical role in endothelial cell stimulation to drive tumor angiogenesis', Cancer Research, vol. 73, pp. 583 - 594, http://dx.doi.org/10.1158/0008-5472.CAN-12-2447
    Journal articles | 2013
    Cox TR; Erler JT, 2013, 'Lysyl oxidase in colorectal cancer', American Journal of Physiology - Gastrointestinal and Liver Physiology, vol. 305, http://dx.doi.org/10.1152/ajpgi.00425.2012
    Journal articles | 2013
    Baker AM; Bird D; Lang G; Cox TR; Erler JT, 2013, 'Lysyl oxidase enzymatic function increases stiffness to drive colorectal cancer progression through FAK', Oncogene, vol. 32, pp. 1863 - 1868, http://dx.doi.org/10.1038/onc.2012.202
    Journal articles | 2013
    Chang J; Nicolau MM; Cox TR; Wetterskog D; Martens JWM; E Barker H; Erler JT, 2013, 'LOXL2 induces aberrant acinar morphogenesis via ErbB2 signaling', Breast Cancer Research, vol. 15, http://dx.doi.org/10.1186/bcr3461
    Journal articles | 2013
    Cox TR; Bird D; Baker AM; Barker HE; Ho MWY; Lang G; Erler JT, 2013, 'LOX-mediated collagen crosslinking is responsible for fibrosis-enhanced metastasis', Cancer Research, vol. 73, pp. 1721 - 1732, http://dx.doi.org/10.1158/0008-5472.CAN-12-2233
    Journal articles | 2013
    R Cox T, 2013, 'The Importance of LOX Family Members on Modulating Cell-ECM Interactions in Carcinogenesis', Journal of Carcinogenesis & Mutagenesis, vol. S13, http://dx.doi.org/10.4172/2157-2518.s13-001
    Journal articles | 2012
    Cox TR; Gartland A; Erler JT, 2012, 'The pre-metastatic niche: is metastasis random?', Bonekey Rep, vol. 1, pp. 80, http://dx.doi.org/10.1038/bonekey.2012.80
    Journal articles | 2012
    Barker HE; Cox TR; Erler JT, 2012, 'The rationale for targeting the LOX family in cancer', Nature Reviews Cancer, vol. 12, pp. 540 - 552, http://dx.doi.org/10.1038/nrc3319
    Journal articles | 2012
    Cox TR; Erler JT, 2012, 'Network biology and the 3-Dimensional tumor microenvironment: personalizing medicine for the future', Tumor Microenvironment and Therapy, vol. 1, http://dx.doi.org/10.2478/tumor-2012-0002
    Journal articles | 2011
    Baker AM; Cox TR; Bird D; Lang G; Murray GI; Sun XF; Southall SM; Wilson JR; Erler JT, 2011, 'The role of lysyl oxidase in SRC-dependent proliferation and metastasis of colorectal cancer', Journal of the National Cancer Institute, vol. 103, pp. 407 - 424, http://dx.doi.org/10.1093/jnci/djq569
    Journal articles | 2011
    Barker HE; Chang J; Cox TR; Lang G; Bird D; Nicolau M; Evans HR; Gartland A; Erler JT, 2011, 'LOXL2-mediated matrix remodeling in metastasis and mammary gland involution', Cancer Research, vol. 71, pp. 1561 - 1572, http://dx.doi.org/10.1158/0008-5472.CAN-10-2868
    Journal articles | 2011
    Cox TR; Erler JT, 2011, 'Remodeling and homeostasis of the extracellular matrix: Implications for fibrotic diseases and cancer', DMM Disease Models and Mechanisms, vol. 4, pp. 165 - 178, http://dx.doi.org/10.1242/dmm.004077
    Journal articles | 2011
    Evans HR; Ab Latif N; Cox TR; Bird D; Lang G; Erler JT; Gartland* A, 2011, 'Tumour-secreted lox mediates osteolytic bone metastases prior to metastatic tumour cell colonisation', Bone, vol. 48, pp. S21 - S21, http://dx.doi.org/10.1016/j.bone.2010.10.054
    Journal articles | 2010
    Graham HK; Hodson NW; Hoyland JA; Millward-Sadler SJ; Garrod D; Scothern A; Griffiths CEM; Watson REB; Cox TR; Erler JT; Trafford AW; Sherratt MJ, 2010, 'Tissue section AFM: In situ ultrastructural imaging of native biomolecules', Matrix Biology, vol. 29, pp. 254 - 260, http://dx.doi.org/10.1016/j.matbio.2010.01.008
    Journal articles | 2009
    Erler JT; Bennewith KL; Cox TR; Lang G; Bird D; Koong A; Le QT; Giaccia AJ, 2009, 'Hypoxia-Induced Lysyl Oxidase Is a Critical Mediator of Bone Marrow Cell Recruitment to Form the Premetastatic Niche', Cancer Cell, vol. 15, pp. 35 - 44, http://dx.doi.org/10.1016/j.ccr.2008.11.012
    Journal articles | 2021
    Murphy KJ; Reed DA; Vennin C; Conway JRW; Nobis M; Yin JX; Chambers CR; Pereira BA; Lee V; Filipe EC; Trpceski M; Ritchie S; Lucas MC; Warren SC; Skhinas JN; Magenau A; Metcalf XL; Stoehr J; Major G; Parkin A; Bidanel R; Lyons RJ; Zaratzian A; Tayao M; Da Silva A; Abdulkhalek L; Gill AJ; Johns AL; Biankin AV; Samra J; Grimmond SM; Chou A; Goetz JG; Samuel MS; Lyons JG; Burgess A; Caldon CE; Horvath LG; Daly RJ; Gadegaard N; Wang Y; Sansom OJ; Morton JP; Cox TR; Pajic M; Herrmann D; Timpson P, 2021, 'Intravital imaging technology guides FAK-mediated priming in pancreatic cancer precision medicine according to Merlin status', Science Advances, vol. 7, http://dx.doi.org/10.1126/sciadv.abh0363
    Journal articles | 2021
    Es HA; Cox TR; Sarafraz-Yazdi E; Thiery JP; Warkiani ME, 2021, 'Pirfenidone reduces epithelial–mesenchymal transition and spheroid formation in breast carcinoma through targeting cancer-associated fibroblasts (Cafs)', Cancers, vol. 13, http://dx.doi.org/10.3390/cancers13205118
    Book Chapters | 2020
    Papanicolaou M; Cox TR, 2020, 'Extracellular Matrix (ECM)', in Encyclopedia of Molecular Pharmacology, Springer International Publishing, pp. 1 - 8, http://dx.doi.org/10.1007/978-3-030-21573-6_5691-1
    Book Chapters | 2017
    El Rayes T; Gao D; Altorki NK; Cox TR; Erler JT; Mittal V, 2017, 'Regulation of tumor progression and metastasis by bone marrow-derived microenvironments', in Biomarkers of the Tumor Microenvironment: Basic Studies and Practical Applications, Springer, pp. 303 - 328, http://dx.doi.org/10.1007/978-3-319-39147-2_13
    Book Chapters | 2013
    Cox TR; Erler JT, 2013, 'Remodelling of the extracellular matrix: Implications for cancer', in Cell and Molecular Biology of Breast Cancer, pp. 65 - 90, http://dx.doi.org/10.1007/978-1-62703-634-4_4
  • Conference Abstracts | 2018
    Hui MN; Cazet A; Elsworth B; Roden D; Cox T; Yang J; McFarland A; Deng N; Chan C-L; O'Toole S; Swarbrick A, 2018, 'Targeting the Hedgehog signalling pathway in triple negative breast cancer.', in JOURNAL OF CLINICAL ONCOLOGY, AMER SOC CLINICAL ONCOLOGY, Vol. 36, http://dx.doi.org/10.1200/JCO.2018.36.15_suppl.e24216
    Conference Papers | 2016
    Høye AM; Tolstrup S; Cox TR; Mauldin JP; Frankel AE; Erler JT, 2016, 'Abstract B17: Disrupting tumor growth through targeting TEM8', in Therapeutic Targeting Tumor Microenvironment, American Association for Cancer Research, presented at Abstracts: AACR Special Conference: The Function of Tumor Microenvironment in Cancer Progression; January 7-10, 2016; San Diego, CA, http://dx.doi.org/10.1158/1538-7445.tme16-b17
    Conference Papers | 2016
    Liu N; Cox TR; Cui W; Adell G; Holmlund B; Erler JT; Sun X, 2016, 'Abstract 5012: Nuclear expression of lysyl oxidase enzyme is an independent prognostic factor in rectal cancer patients', in Clinical Research (Excluding Clinical Trials), American Association for Cancer Research, presented at Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA, http://dx.doi.org/10.1158/1538-7445.am2016-5012
    Preprints |
    Valdes-Mora F; Salomon R; Gloss B; Law AMK; Castillo L; Murphy K; Venhuizen J; Magenau A; Papanicolau M; Rodriguez de la Fuente L; Roden DL; Colino-Sanguino Y; Kikhtyak Z; Farbehi N; Conway JRW; Oakes SR; Sikta N; O'Donoghue SI; Cox TR; Timpson P; Ormandy CJ; Gallego Ortega D, Single Cell Transcriptomics Reveals Involution Mimicry During the Specification of the Basal Breast Cancer Subtype, http://dx.doi.org/10.2139/ssrn.3634808
    Preprints |
    Cazet AS; Hui MN; Elsworth BL; Wu SZ; Roden D; Chan C-L; Skhinas JN; Collot R; Yang J; Harvey K; Johan MZ; Cooper C; Nair R; Herrmann D; McFarland A; Deng N-T; Ruiz-Borrego M; Rojo F; Trigo JM; Bezares S; Caballero R; Lim E; Timpson P; O’Toole S; Watkins DN; Cox TR; Samuel M; Martín M; Swarbrick A, Targeting stromal remodeling and cancer stem cell plasticity to overcome chemoresistance in triple negative breast cancer, http://dx.doi.org/10.1101/215954
    Preprints |
    Sharbeen G; McCarroll JA; Akerman A; Kopecky C; Youkhana J; Holst J; Boyer C; Erkan M; Goldstein D; Timpson P; Cox TR; Pereira BA; Chitty JL; Fey S; Najumudeen AK; Campbell AD; Sansom OJ; Ignacio RMC; Naim S; Liu J; Russia N; Lee J; Chou A; Johns A; Gill A; Gonzales-Aloy E; Kokkinos J; Gebski V; Turner N; Apte M; Davis TP; Morton JP; Haghighi K; Phillips PA, Cancer-associated fibroblasts in pancreatic ductal adenocarcinoma determine response to SLC7A11 inhibition, http://dx.doi.org/10.1101/2020.07.12.199638
    Preprints |
    Es HA; Aref AR; Kulasinghe A; Cox TR; Thiery JP; Ebrahimi Warkiani M, Epithelial-Mesenchymal Transition Inversely Associates With Immune Activity in Breast Cancer Tumour Immune Microenvironment, http://dx.doi.org/10.2139/ssrn.3811836
    Preprints |
    Wullkopf L; Jensen LE; Horton ER; Mayorca Guiliani AE; Madsen CD; Cox TR; Reuten R; Erler JT, Breast Cancer-Secreted Laminin γ2 Promotes Metastatic Progression Through Attraction of Blood Vessels, http://dx.doi.org/10.2139/ssrn.3631394
    Preprints |
    Rad MA; Mahmodi H; Filipe EC; Cox TR; Kabakova I; Tipper JL, Micromechanical Characterisation of 3D Bioprinted neural cell models using Brillouin Microscopy, http://dx.doi.org/10.1101/2021.08.17.456575
    Journal articles | 2022
    Rad MA; Mahmodi H; Filipe EC; Cox TR; Kabakova I; Tipper JL, 2022, 'Micromechanical characterisation of 3D bioprinted neural cell models using Brillouin microspectroscopy', Bioprinting, vol. 25, pp. e00179 - e00179, http://dx.doi.org/10.1016/j.bprint.2021.e00179
    Journal articles | 2021
    Es HA; Cox TR; Sarafraz-Yazdi E; Thiery JP; Warkiani ME, 2021, 'Pirfenidone reduces epithelial–mesenchymal transition and spheroid formation in breast carcinoma through targeting cancer-associated fibroblasts (Cafs)', Cancers, vol. 13, http://dx.doi.org/10.3390/cancers13205118
    Journal articles | 2021
    Valdés-Mora F; Salomon R; Gloss BS; Law AMK; Venhuizen J; Castillo L; Murphy KJ; Magenau A; Papanicolaou M; Rodriguez de la Fuente L; Roden DL; Colino-Sanguino Y; Kikhtyak Z; Farbehi N; Conway JRW; Sikta N; Oakes SR; Cox TR; O'Donoghue SI; Timpson P; Ormandy CJ; Gallego-Ortega D, 2021, 'Single-cell transcriptomics reveals involution mimicry during the specification of the basal breast cancer subtype', Cell Reports, vol. 35, http://dx.doi.org/10.1016/j.celrep.2021.108945
    Journal articles | 2021
    Cox TR, 2021, 'The matrix in cancer', Nature Reviews Cancer, vol. 21, pp. 217 - 238, http://dx.doi.org/10.1038/s41568-020-00329-7
    Journal articles | 2021
    Sharbeen G; McCarroll JA; Akerman A; Kopecky C; Youkhana J; Kokkinos J; Holst J; Boyer C; Erkan M; Goldstein D; Timpson P; Cox TR; Pereira BA; Chitty JL; Fey SK; Najumudeen AK; Campbell AD; Sansom OJ; Ignacio RMC; Naim S; Liu J; Russia N; Lee J; Chou A; Johns A; Gill AJ; Gonzales-Aloy E; Gebski V; Guan YF; Pajic M; Turner N; Apte MV; Davis TP; Morton JP; Haghighi KS; Kasparian J; McLean BJ; Setargew YF; Phillips PA, 2021, 'Cancer-associated fibroblasts in pancreatic ductal adenocarcinoma determine response to slc7a11 inhibition', Cancer Research, vol. 81, pp. 3461 - 3479, http://dx.doi.org/10.1158/0008-5472.CAN-20-2496
    Journal articles | 2021
    Lakis V; Lawlor RT; Newell F; Patch AM; Mafficini A; Sadanandam A; Koufariotis LT; Johnston RL; Leonard C; Wood S; Rusev B; Corbo V; Luchini C; Cingarlini S; Landoni L; Salvia R; Milella M; Chang D; Bailey P; Jamieson NB; Duthie F; Gingras MC; Muzny DM; Wheeler DA; Gibbs RA; Milione M; Chantrill LA; Timpson P; Chou A; Pajic M; Murphy A; Dwarte T; Hermann D; Vennin C; Cox TR; Pereira B; Ritchie S; Reed DA; Chambers CR; Metcalf X; Nobis M; Mukhopadhyay P; Addala V; Kazakoff S; Holmes O; Xu Q; Hofmann O; Samra JS; Pavlakis N; Arena J; High HA; Asghari R; Merrett ND; Pavey D; Das A; Cosman PH; Ismail K; O’Connnor C; Stoita A; Williams D; Spigellman A; Lam VW; McLeod D; Kirk J; Kench JG; Grimison P; Sandroussi C; Goodwin A; Mead RS; Tucker K; Andrews L; Texler M; Forest C; Ballal M; Fletcher DR; Zeps N; Nguyen NQ; Ruszkiewicz AR; Worthley C; Chen J; Brooke-Smith ME; Papangelis V; Clouston AD; Barbour AP; O’Rourke TJ; Fawcett JW; Slater K; Hatzifotis M; Hodgkinson P; Nikfarjam M; Eshleman JR; Hruban RH; Wolfgang CL; Dixon J; Scardoni M; Bassi C; Grimaldi S; Cantù C; Bonizzato G; Bersani S, 2021, 'DNA methylation patterns identify subgroups of pancreatic neuroendocrine tumors with clinical association', Communications Biology, vol. 4, http://dx.doi.org/10.1038/s42003-020-01469-0
    Journal articles | 2021
    Polonchuk L; Surija L; Lee MH; Sharma P; Ming CLC; Richter F; Ben-Sefer E; Rad MA; Sarmast HMS; Al Shamery W; Tran HA; Vettori L; Haeusermann F; Filipe EC; Rnjak-Kovacina J; Cox T; Tipper J; Kabakova I; Gentile C, 2021, 'Towards engineering heart tissues from bioprinted cardiac spheroids', Biofabrication, vol. 13, http://dx.doi.org/10.1088/1758-5090/ac14ca
    Journal articles | 2021
    Setargew YFI; Wyllie K; Grant RD; Chitty JL; Cox TR, 2021, 'Targeting lysyl oxidase family meditated matrix cross‐linking as an anti‐stromal therapy in solid tumours', Cancers, vol. 13, pp. 1 - 26, http://dx.doi.org/10.3390/cancers13030491
    Journal articles | 2021
    Holliday H; Roden D; Junankar S; Wu SZ; Baker LA; Krisp C; Chan CL; McFarland A; Skhinas JN; Cox TR; Pal B; Huntington ND; Ormandy CJ; Carroll JS; Visvader J; Molloy MP; Swarbrick A, 2021, 'Inhibitor of Differentiation 4 (ID4) represses mammary myoepithelial differentiation via inhibition of HEB', iScience, vol. 24, pp. 102072 - 102072, http://dx.doi.org/10.1016/j.isci.2021.102072
    Journal articles | 2021
    Murphy KJ; Reed DA; Vennin C; Conway JRW; Nobis M; Yin JX; Chambers CR; Pereira BA; Lee V; Filipe EC; Trpceski M; Ritchie S; Lucas MC; Warren SC; Skhinas JN; Magenau A; Metcalf XL; Stoehr J; Major G; Parkin A; Bidanel R; Lyons RJ; Zaratzian A; Tayao M; Da Silva A; Abdulkhalek L; Gill AJ; Johns AL; Biankin AV; Samra J; Grimmond SM; Chou A; Goetz JG; Samuel MS; Lyons JG; Burgess A; Caldon CE; Horvath LG; Daly RJ; Gadegaard N; Wang Y; Sansom OJ; Morton JP; Cox TR; Pajic M; Herrmann D; Timpson P, 2021, 'Intravital imaging technology guides FAK-mediated priming in pancreatic cancer precision medicine according to Merlin status', Science Advances, vol. 7, http://dx.doi.org/10.1126/sciadv.abh0363
    Journal articles | 2021
    Guo G; Papanicolaou M; Demarais NJ; Wang Z; Schey KL; Timpson P; Cox TR; Grey AC, 2021, 'Automated annotation and visualisation of high-resolution spatial proteomic mass spectrometry imaging data using HIT-MAP', Nature Communications, vol. 12, pp. 3241, http://dx.doi.org/10.1038/s41467-021-23461-w
    Journal articles | 2020
    Elgundi Z; Papanicolaou M; Major G; Cox TR; Melrose J; Whitelock JM; Farrugia BL, 2020, 'Cancer Metastasis: The Role of the Extracellular Matrix and the Heparan Sulfate Proteoglycan Perlecan', Frontiers in Oncology, vol. 9, http://dx.doi.org/10.3389/fonc.2019.01482
    Journal articles | 2020
    Parker AL; Cox TR, 2020, 'The Role of the ECM in Lung Cancer Dormancy and Outgrowth', Frontiers in Oncology, vol. 10, http://dx.doi.org/10.3389/fonc.2020.01766
    Journal articles | 2020
    Chitty JL; Skhinas JN; Filipe EC; Wang S; Cupello CR; Grant RD; Yam M; Papanicolaou M; Major G; Zaratzian A; Da Silva AM; Tayao M; Vennin C; Timpson P; Madsen CD; Cox TR, 2020, 'The Mini-Organo: A rapid high-throughput 3D coculture organotypic assay for oncology screening and drug development', Cancer Reports, vol. 3, http://dx.doi.org/10.1002/cnr2.1209
    Journal articles | 2020
    Wu SZ; Roden DL; Wang C; Holliday H; Harvey K; Cazet AS; Murphy KJ; Pereira B; Al-Eryani G; Bartonicek N; Hou R; Torpy JR; Junankar S; Chan CL; Lam CE; Hui MN; Gluch L; Beith J; Parker A; Robbins E; Segara D; Mak C; Cooper C; Warrier S; Forrest A; Powell J; O'Toole S; Cox TR; Timpson P; Lim E; Liu XS; Swarbrick A, 2020, 'Stromal cell diversity associated with immune evasion in human triple-negative breast cancer', EMBO Journal, vol. 39, http://dx.doi.org/10.15252/embj.2019104063
    Journal articles | 2020
    Michael P; Lam YT; Filipe EC; Tan RP; Chan AHP; Lee BSL; Feng N; Hung J; Cox TR; Santos M; Wise SG, 2020, 'Plasma polymerized nanoparticles effectively deliver dual siRNA and drug therapy in vivo', Scientific Reports, vol. 10, http://dx.doi.org/10.1038/s41598-020-69591-x
    Journal articles | 2020
    Wu S; Roden D; Wang C; Holliday H; Harvey K; Cazet A; Murphy K; Pereira B; Al-Eryani G; Bartonicek N; Hou R; Torpy J; Junankar S; Chan C-L; Lam E; Hui M; Gluch L; Beith J; Parker A; Robbins E; Segara D; Mak C; Cooper C; Warrier S; Forrest A; Powell J; O’Toole S; Cox T; Timpson P; Lim E; Liu S; Swarbrick A, 2020, 'Single-cell analysis reveals diverse stromal subsets associated with immune evasion in triple-negative breast cancer', bioRxiv, http://dx.doi.org/10.1101/2020.06.04.135327
    Journal articles | 2020
    Nobis M; Herrmann D; Warren SC; Strathdee D; Cox TR; Anderson KI; Timpson P, 2020, 'Shedding new light on RhoA signalling as a drug target in vivo using a novel RhoA-FRET biosensor mouse', Small GTPases, vol. 11, pp. 240 - 247, http://dx.doi.org/10.1080/21541248.2018.1438024
    Journal articles | 2019
    Kennedy SP; Han JZR; Portman N; Nobis M; Hastings JF; Murphy KJ; Latham SL; Cadell AL; Miladinovic D; Marriott GR; O'Donnell YEI; Shearer RF; Williams JT; Munoz AG; Cox TR; Watkins DN; Saunders DN; Timpson P; Lim E; Kolch W; Croucher DR, 2019, 'Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer', Breast Cancer Research, vol. 21, pp. 43, http://dx.doi.org/10.1186/s13058-019-1127-y
    Journal articles | 2019
    Hastings JF; Skhinas JN; Fey D; Croucher DR; Cox TR, 2019, 'The extracellular matrix as a key regulator of intracellular signalling networks', British Journal of Pharmacology, vol. 176, pp. 82 - 92, http://dx.doi.org/10.1111/bph.14195
    Journal articles | 2019
    Vennin C; Mélénec P; Rouet R; Nobis M; Cazet AS; Murphy KJ; Herrmann D; Reed DA; Lucas MC; Warren SC; Elgundi Z; Pinese M; Kalna G; Roden D; Samuel M; Zaratzian A; Grey ST; Da Silva A; Leung W; Johns AL; Chantrill LA; Chou A; Steinmann A; Arshi M; Dwarte T; Froio D; Pereira B; Ritchie S; Chambers CR; Metcalf X; Waddell N; Pearson JV; Patch AM; Nones K; Newell F; Mukhopadhyay P; Addala V; Kazakoff S; Holmes O; Leonard C; Wood S; Grimmond SM; Hofmann O; Christ A; Bruxner T; Samra JS; Pavlakis N; High HA; Asghari R; Merrett ND; Pavey D; Das A; Cosman PH; Ismail K; O’Connnor C; Stoita A; Williams D; Spigellman A; Lam VW; McLeod D; Kirk J; Kench JG; Grimison P; Cooper CL; Sandroussi C; Goodwin A; Mead RS; Tucker K; Andrews L; Texler M; Forest C; Epari KP; Ballal M; Fletcher DR; Mukhedkar S; Zeps N; Beilin M; Feeney K; Nguyen NQ; Ruszkiewicz AR; Worthley C; Chen J; Brooke-Smith ME; Papangelis V; Clouston AD; Barbour AP; O’Rourke TJ; Fawcett JW; Slater K; Hatzifotis M; Hodgkinson P; Nikfarjam M; Eshleman JR; Hruban RH; Wolfgang CL; Lawlor RT; Beghelli S; Corbo V; Scardoni M; Bassi C, 2019, 'CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan', Nature Communications, vol. 10, pp. 3637, http://dx.doi.org/10.1038/s41467-019-10968-6
    Journal articles | 2019
    Zijlstra A; Von Lersner A; Yu D; Borrello L; Oudin M; Kang Y; Sahai E; Fingleton B; Stein U; Cox TR; Price JT; Kato Y; Welm AL; Aguirre-Ghiso JA, 2019, 'The importance of developing therapies targeting the biological spectrum of metastatic disease', Clinical and Experimental Metastasis, vol. 36, pp. 305 - 309, http://dx.doi.org/10.1007/s10585-019-09972-3
    Journal articles | 2019
    Nguyen EV; Pereira BA; Lawrence MG; Ma X; Rebello RJ; Chan H; Niranjan B; Wu Y; Ellem S; Guan X; Wu J; Skhinas JN; Cox TR; Risbridger GP; Taylor RA; Lister NL; Daly RJ, 2019, 'Proteomic profiling of human prostate cancer-associated fibroblasts (CAF) reveals LOXL2-dependent regulation of the tumor microenvironment', Molecular and Cellular Proteomics, vol. 18, pp. 1410 - 1427, http://dx.doi.org/10.1074/mcp.RA119.001496
    Journal articles | 2019
    Beadnell T; Borriello L; Christenson J; Fornetti J; Guldner I; Hanna A; Kyjacova L; Marinak-Whately K; de Melo Martins PC; Rotinen M; te Boekhorst V; Cox TR, 2019, 'Meeting report: Metastasis Research Society (MRS) 17th Biennial conference and associated Young Investigator Satellite Meeting (YISM) on cancer metastasis', Clinical and Experimental Metastasis, vol. 36, pp. 119 - 137, http://dx.doi.org/10.1007/s10585-018-09953-y
    Journal articles | 2019
    Chitty JL; Setargew YFI; Cox TR, 2019, 'Targeting the lysyl oxidases in tumour desmoplasia', Biochemical Society Transactions, vol. 47, pp. 1661 - 1678, http://dx.doi.org/10.1042/BST20190098
    Journal articles | 2019
    Zeltz C; Pasko E; Cox TR; Navab R; Tsao MS, 2019, 'LOXL1 is regulated by integrin α11 and promotes non-small cell lung cancer tumorigenicity', Cancers, vol. 11, http://dx.doi.org/10.3390/cancers11050705
    Journal articles | 2019
    Pereira BA; Vennin C; Papanicolaou M; Chambers CR; Herrmann D; Morton JP; Cox TR; Timpson P, 2019, 'CAF Subpopulations: A New Reservoir of Stromal Targets in Pancreatic Cancer', Trends in Cancer, vol. 5, pp. 724 - 741, http://dx.doi.org/10.1016/j.trecan.2019.09.010
    Journal articles | 2019
    Nguyen EV; Pereira BA; Lawrence MG; Ma X; Rebello RJ; Chan H; Niranjan B; Wu Y; Ellem S; Guan X; Wu J; Skhinas JN; Cox TR; Risbridger GP; Taylor RA; Lister NL; Daly RJ, 2019, 'Proteomic Profiling of Human Prostate Cancer-associated Fibroblasts (CAF) Reveals LOXL2-dependent Regulation of the Tumor Microenvironment.', Mol Cell Proteomics, vol. 18, pp. 1410 - 1427, http://dx.doi.org/10.1074/mcp.RA119.001496
    Journal articles | 2018
    Warren SC; Nobis M; Magenau A; Mohammed YH; Herrmann D; Moran I; Vennin C; Conway JRW; Mélénec P; Cox TR; Wang Y; Morton JP; Welch HCE; Strathdee D; Anderson KI; Phan TG; Roberts MS; Timpson P, 2018, 'Removing physiological motion from Intravital and clinical functional imaging data', eLife, vol. 7, http://dx.doi.org/10.7554/eLife.35800
    Journal articles | 2018
    Chou A; Froio D; Nagrial AM; Parkin A; Murphy KJ; Chin VT; Wohl D; Steinmann A; Stark R; Drury A; Walters SN; Vennin C; Burgess A; Pinese M; Chantrill LA; Cowley MJ; Molloy TJ; Waddell N; Johns A; Grimmond SM; Chang DK; Biankin AV; Sansom OJ; Morton JP; Grey ST; Cox TR; Turchini J; Samra J; Clarke SJ; Timpson P; Gill AJ; Pajic M, 2018, 'Tailored first-line and second-line CDK4-targeting treatment combinations in mouse models of pancreatic cancer', Gut, vol. 67, pp. 2142 - 2155, http://dx.doi.org/10.1136/gutjnl-2017-315144
    Journal articles | 2018
    Wullkopf L; West AKV; Leijnse N; Cox TR; Madsen CD; Oddershede LB; Erler JT, 2018, 'Cancer cells' ability to mechanically adjust to extracellular matrix stiffness correlates with their invasive potential', Molecular Biology of the Cell, vol. 29, pp. 2378 - 2385, http://dx.doi.org/10.1091/mbc.E18-05-0319
    Journal articles | 2018
    Chitty JL; Filipe EC; Lucas MC; Herrmann D; Cox TR; Timpson P, 2018, 'Recent advances in understanding the complexities of metastasis', F1000Research, vol. 7, http://dx.doi.org/10.12688/f1000research.15064.2
    Journal articles | 2018
    Xia T; Horton ER; Salcini AE; Pocock R; Cox TR; Erler JT, 2018, 'Proteomic Characterization of Caenorhabditis elegans Larval Development', Proteomics, vol. 18, http://dx.doi.org/10.1002/pmic.201700238
    Journal articles | 2018
    Cazet AS; Hui MN; Elsworth BL; Wu SZ; Roden D; Chan CL; Skhinas JN; Collot R; Yang J; Harvey K; Johan MZ; Cooper C; Nair R; Herrmann D; McFarland A; Deng N; Ruiz-Borrego M; Rojo F; Trigo JM; Bezares S; Caballero R; Lim E; Timpson P; O’Toole S; Watkins DN; Cox TR; Samuel MS; Martín M; Swarbrick A, 2018, 'Targeting stromal remodeling and cancer stem cell plasticity overcomes chemoresistance in triple negative breast cancer', Nature Communications, vol. 9, http://dx.doi.org/10.1038/s41467-018-05220-6
    Journal articles | 2018
    Vennin C; Murphy KJ; Morton JP; Cox TR; Pajic M; Timpson P, 2018, 'Reshaping the Tumor Stroma for Treatment of Pancreatic Cancer', Gastroenterology, vol. 154, pp. 820 - 838, http://dx.doi.org/10.1053/j.gastro.2017.11.280
    Journal articles | 2018
    Skhinas JN; Cox TR, 2018, 'The interplay between extracellular matrix remodelling and kinase signalling in cancer progression and metastasis', Cell Adhesion and Migration, vol. 12, pp. 529 - 537, http://dx.doi.org/10.1080/19336918.2017.1405208
    Journal articles | 2018
    Høye AM; Tolstrup SD; Horton ER; Nicolau M; Frost H; Woo JH; Mauldin JP; Frankel AE; Cox TR; Erler JT, 2018, 'Tumor endothelial marker 8 promotes cancer progression and metastasis', Oncotarget, vol. 9, pp. 30173 - 30188, http://dx.doi.org/10.18632/oncotarget.25734
    Journal articles | 2018
    Murphy K; Vennin C; Cox T; Wang Y; Morton J; Sansom O; Pajic M; Herrmann D; Timpson P, 2018, 'PO-229 Transient tissue ‘priming’ via FAK inhibition to impair pancreatic ductal adenocarcinoma (PDAC) progression to improve sensitivity to gemcitabine/abraxane', ESMO Open, vol. 3, pp. A316 - A317, http://dx.doi.org/10.1136/esmoopen-2018-eacr25.746
    Journal articles | 2018
    Filipe EC; Chitty JL; Cox TR, 2018, 'Charting the unexplored extracellular matrix in cancer', International Journal of Experimental Pathology, vol. 99, pp. 58 - 76, http://dx.doi.org/10.1111/iep.12269
    Journal articles | 2018
    Cox TR; Erler JT; Rumney RMH, 2018, 'Established Models and New Paradigms for Hypoxia-Driven Cancer-Associated Bone Disease', Calcified Tissue International, vol. 102, pp. 163 - 173, http://dx.doi.org/10.1007/s00223-017-0352-6
    Journal articles | 2017
    Vennin C; Chin VT; Warren SC; Lucas MC; Herrmann D; Magenau A; Melenec P; Walters SN; Del Monte-Nieto G; Conway JRW; Nobis M; Allam AH; McCloy RA; Currey N; Pinese M; Boulghourjian A; Zaratzian A; Adam AAS; Heu C; Nagrial AM; Chou A; Steinmann A; Drury A; Froio D; Giry-Laterriere M; Harris NLE; Phan T; Jain R; Weninger W; McGhee EJ; Whan R; Johns AL; Samra JS; Chantrill L; Gill AJ; Kohonen-Corish M; Harvey RP; Biankin AV; Evans TRJ; Anderson KI; Grey ST; Ormandy CJ; Gallego-Ortega D; Wang Y; Samuel MS; Sansom OJ; Burgess A; Cox TR; Morton JP; Pajic M; Timpson P, 2017, 'Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis', Science Translational Medicine, vol. 9, http://dx.doi.org/10.1126/scitranslmed.aai8504
    Journal articles | 2017
    Liu N; Cox TR; Cui W; Adell G; Holmlund B; Ping J; Jarlsfelt I; Erler JT; Sun XF, 2017, 'Nuclear expression of lysyl oxidase enzyme is an independent prognostic factor in rectal cancer patients', Oncotarget, vol. 8, pp. 60015 - 60024, http://dx.doi.org/10.18632/oncotarget.9623
    Journal articles | 2017
    Liu N; Cox TR; Cui W; Adell G; Holmlund B; Ping J; Jarlsfelt I; Erler JT; Sun X-F, 2017, 'Nuclear expression of lysyl oxidase enzyme is an independent prognostic factor in rectal cancer patients.', Oncotarget, vol. 8, pp. 60015 - 60024, http://dx.doi.org/10.18632/oncotarget.9623
    Journal articles | 2017
    Mayorca-Guiliani AE; Madsen CD; Cox TR; Horton ER; Venning FA; Erler JT, 2017, 'ISDoT: In situ decellularization of tissues for high-resolution imaging and proteomic analysis of native extracellular matrix', Nature Medicine, vol. 23, pp. 890 - 898, http://dx.doi.org/10.1038/nm.4352
    Journal articles | 2017
    Peinado H; Zhang H; Matei IR; Costa-Silva B; Hoshino A; Rodrigues G; Psaila B; Kaplan RN; Bromberg JF; Kang Y; Bissell MJ; Cox TR; Giaccia AJ; Erler JT; Hiratsuka S; Ghajar CM; Lyden D, 2017, 'Pre-metastatic niches: Organ-specific homes for metastases', Nature Reviews Cancer, vol. 17, pp. 302 - 317, http://dx.doi.org/10.1038/nrc.2017.6
    Journal articles | 2017
    Madsen CD; Cox TR, 2017, 'Relative Stiffness Measurements of Tumour Tissues by Shear Rheology', BIO-PROTOCOL, vol. 7, http://dx.doi.org/10.21769/BioProtoc.2265
    Journal articles | 2017
    Fingleton B; Lange K; Caldwell B; Bankaitis KV; Kang Y; Yu D; Aguirre-Ghiso J; Cox TR; Erler JT; Gelman IH; Hurst DR; Kato Y; Lynch CC; Price JT; Samant RS; Sleeman J; Stein U; Zijlstra A, 2017, 'Perspective on the interpretation of research and translation to clinical care with therapy-associated metastatic breast cancer progression as an example', Clinical and Experimental Metastasis, vol. 34, pp. 443 - 447, http://dx.doi.org/10.1007/s10585-017-9872-8
    Journal articles | 2017
    Conway JRW; Vennin C; Cazet AS; Herrmann D; Murphy KJ; Warren SC; Wullkopf L; Boulghourjian A; Zaratzian A; Da Silva AM; Pajic M; Morton JP; Cox TR; Timpson P, 2017, 'Three-dimensional organotypic matrices from alternative collagen sources as pre-clinical models for cell biology', Scientific Reports, vol. 7, http://dx.doi.org/10.1038/s41598-017-17177-5
    Journal articles | 2017
    Vennin C; Cox TR; Pajic M; Timpson P, 2017, 'Transient targeting of the pancreatic cancer stroma as a 'finetuned' anti-tumor and anti-metastatic therapy', Oncotarget, vol. 8, pp. 84635 - 84636, http://dx.doi.org/10.18632/oncotarget.21468
    Journal articles | 2017
    Chang J; Lucas MC; Leonte LE; Garcia-Montolio M; Singh LB; Findlay AD; Deodhar M; Foot JS; Jarolimek W; Timpson P; Erler JT; Cox TR, 2017, 'Pre-clinical evaluation of small molecule LOXL2 inhibitors in breast cancer', Oncotarget, vol. 8, pp. 26066 - 26078, http://dx.doi.org/10.18632/oncotarget.15257
    Journal articles | 2017
    Cox TR; Madsen CD, 2017, 'Relative Stiffness Measurements of Cell-embedded Hydrogels by Shear Rheology in vitro.', Bio Protoc, vol. 7, pp. e2101, http://dx.doi.org/10.21769/BioProtoc.2101
    Journal articles | 2017
    Elyas E; Papaevangelou E; Alles EJ; Erler JT; Cox TR; Robinson SP; Bamber JC, 2017, 'Correlation of ultrasound shear wave elastography with pathological analysis in a xenografic tumour model', Scientific Reports, vol. 7, http://dx.doi.org/10.1038/s41598-017-00144-5
    Journal articles | 2017
    Koplev S; Longden J; Ferkinghoff-Borg J; Blicher Bjerregård M; Cox TR; Erler JT; Pedersen JT; Voellmy F; Sommer MOA; Linding R, 2017, 'Dynamic Rearrangement of Cell States Detected by Systematic Screening of Sequential Anticancer Treatments', Cell Reports, vol. 20, pp. 2784 - 2791, http://dx.doi.org/10.1016/j.celrep.2017.08.095
    Journal articles | 2017
    Elyas E; Grimwood A; Erler JT; Robinson SP; Cox TR; Woods D; Clowes P; De Luca R; Marinozzi F; Fromageau J; Bamber JC, 2017, 'Multi-channel optical coherence elastography using relative and absolute shear-wave time of flight', PLoS ONE, vol. 12, http://dx.doi.org/10.1371/journal.pone.0169664
    Journal articles | 2017
    Bankaitis K; Borriello L; Cox T; Lynch C; Zijlstra A; Fingleton B; Gužvić M; Anderson R; Neman J, 2017, 'Meeting report: Metastasis Research Society–Chinese Tumor Metastasis Society joint conference on metastasis', Clinical and Experimental Metastasis, vol. 34, pp. 203 - 213, http://dx.doi.org/10.1007/s10585-017-9842-1
    Journal articles | 2016
    Cox TR; Erler JT, 2016, 'Fibrosis and Cancer: Partners in Crime or Opposing Forces?', Trends in Cancer, vol. 2, pp. 279 - 282, http://dx.doi.org/10.1016/j.trecan.2016.05.004
    Journal articles | 2016
    Gartland A; Erler JT; Cox TR, 2016, 'The role of lysyl oxidase, the extracellular matrix and the pre-metastatic niche in bone metastasis', Journal of Bone Oncology, vol. 5, pp. 100 - 103, http://dx.doi.org/10.1016/j.jbo.2016.04.001
    Journal articles | 2016
    Cox TR; Gartland A; Erler JT, 2016, 'Lysyl oxidase, a targetable secreted molecule involved in cancer metastasis', Cancer Research, vol. 76, pp. 188 - 192, http://dx.doi.org/10.1158/0008-5472.CAN-15-2306
    Journal articles | 2015
    Madsen CD; Pedersen JT; Venning FA; Singh LB; Moeendarbary E; Charras G; Cox TR; Sahai E; Erler JT, 2015, 'Hypoxia and loss of PHD2 inactivate stromal fibroblasts to decrease tumour stiffness and metastasis', EMBO Reports, vol. 16, pp. 1394 - 1408, http://dx.doi.org/10.15252/embr.201540107
    Journal articles | 2015
    Cox TR; Rumney RMH; Schoof EM; Perryman L; Høye AM; Agrawal A; Bird D; Latif NA; Forrest H; Evans HR; Huggins ID; Lang G; Linding R; Gartland A; Erler JT, 2015, 'The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase', Nature, vol. 522, pp. 106 - 110, http://dx.doi.org/10.1038/nature14492
    Journal articles | 2015
    Rodriguez-Teja M; Gronau JH; Breit C; Zhang YZ; Minamidate A; Caley MP; McCarthy A; Cox TR; Erler JT; Gaughan L; Darby S; Robson C; Mauri F; Waxman J; Sturge J, 2015, 'AGE-modified basement membrane cooperates with Endo180 to promote epithelial cell invasiveness and decrease prostate cancer survival', Journal of Pathology, vol. 235, pp. 581 - 592, http://dx.doi.org/10.1002/path.4485
    Journal articles | 2015
    Creixell P; Schoof EM; Simpson CD; Longden J; Miller CJ; Lou HJ; Perryman L; Cox TR; Zivanovic N; Palmeri A; Wesolowska-Andersen A; Helmer-Citterich M; Ferkinghoff-Borg J; Itamochi H; Bodenmiller B; Erler JT; Turk BE; Linding R, 2015, 'Kinome-wide Decoding of Network-Attacking Mutations Rewiring Cancer Signaling', Cell, vol. 163, pp. 202 - 217, http://dx.doi.org/10.1016/j.cell.2015.08.056
    Journal articles | 2015
    Cox TR; Schoof EM; Gartland A; Erler JT; Linding R, 2015, 'Dataset for the proteomic inventory and quantitative analysis of the breast cancer hypoxic secretome associated with osteotropism', Data in Brief, vol. 5, pp. 621 - 625, http://dx.doi.org/10.1016/j.dib.2015.09.039
    Journal articles | 2014
    Cox TR; Erler JT, 2014, 'Molecular pathways: Connecting fibrosis and solid tumor metastasis', Clinical Cancer Research, vol. 20, pp. 3637 - 3643, http://dx.doi.org/10.1158/1078-0432.CCR-13-1059
    Journal articles | 2014
    Cox TR; Erler JT, 2014, 'Fibrosis, cancer and the premetastatic niche', Breast Cancer Management, vol. 3, pp. 453 - 455, http://dx.doi.org/10.2217/bmt.14.36
    Journal articles | 2013
    Cox TR; Bird D; Baker AM; Barker HE; Ho MWY; Lang G; Erler JT, 2013, 'LOX-mediated collagen crosslinking is responsible for fibrosis-enhanced metastasis', Cancer Research, vol. 73, pp. 1721 - 1732, http://dx.doi.org/10.1158/0008-5472.CAN-12-2233
    Journal articles | 2013
    Baker AM; Bird D; Lang G; Cox TR; Erler JT, 2013, 'Lysyl oxidase enzymatic function increases stiffness to drive colorectal cancer progression through FAK', Oncogene, vol. 32, pp. 1863 - 1868, http://dx.doi.org/10.1038/onc.2012.202
    Journal articles | 2013
    Baker AM; Bird D; Welti JC; Gourlaouen M; Lang G; Murray GI; Reynolds AR; Cox TR; Erler JT, 2013, 'Lysyl oxidase plays a critical role in endothelial cell stimulation to drive tumor angiogenesis', Cancer Research, vol. 73, pp. 583 - 594, http://dx.doi.org/10.1158/0008-5472.CAN-12-2447
    Journal articles | 2013
    Cox TR; Erler JT, 2013, 'Lysyl oxidase in colorectal cancer', American Journal of Physiology - Gastrointestinal and Liver Physiology, vol. 305, http://dx.doi.org/10.1152/ajpgi.00425.2012
    Journal articles | 2013
    Chang J; Nicolau MM; Cox TR; Wetterskog D; Martens JWM; E Barker H; Erler JT, 2013, 'LOXL2 induces aberrant acinar morphogenesis via ErbB2 signaling', Breast Cancer Research, vol. 15, http://dx.doi.org/10.1186/bcr3461
    Journal articles | 2013
    R Cox T, 2013, 'The Importance of LOX Family Members on Modulating Cell-ECM Interactions in Carcinogenesis', Journal of Carcinogenesis & Mutagenesis, vol. S13, http://dx.doi.org/10.4172/2157-2518.s13-001
    Journal articles | 2012
    Barker HE; Cox TR; Erler JT, 2012, 'The rationale for targeting the LOX family in cancer', Nature Reviews Cancer, vol. 12, pp. 540 - 552, http://dx.doi.org/10.1038/nrc3319
    Journal articles | 2012
    Cox TR; Gartland A; Erler JT, 2012, 'The pre-metastatic niche: is metastasis random?', Bonekey Rep, vol. 1, pp. 80, http://dx.doi.org/10.1038/bonekey.2012.80
    Journal articles | 2012
    Cox TR; Erler JT, 2012, 'Network biology and the 3-Dimensional tumor microenvironment: personalizing medicine for the future', Tumor Microenvironment and Therapy, vol. 1, http://dx.doi.org/10.2478/tumor-2012-0002
    Journal articles | 2011
    Cox TR; Erler JT, 2011, 'Remodeling and homeostasis of the extracellular matrix: Implications for fibrotic diseases and cancer', DMM Disease Models and Mechanisms, vol. 4, pp. 165 - 178, http://dx.doi.org/10.1242/dmm.004077
    Journal articles | 2011
    Baker AM; Cox TR; Bird D; Lang G; Murray GI; Sun XF; Southall SM; Wilson JR; Erler JT, 2011, 'The role of lysyl oxidase in SRC-dependent proliferation and metastasis of colorectal cancer', Journal of the National Cancer Institute, vol. 103, pp. 407 - 424, http://dx.doi.org/10.1093/jnci/djq569
    Journal articles | 2011
    Barker HE; Chang J; Cox TR; Lang G; Bird D; Nicolau M; Evans HR; Gartland A; Erler JT, 2011, 'LOXL2-mediated matrix remodeling in metastasis and mammary gland involution', Cancer Research, vol. 71, pp. 1561 - 1572, http://dx.doi.org/10.1158/0008-5472.CAN-10-2868
    Journal articles | 2011
    Evans HR; Ab Latif N; Cox TR; Bird D; Lang G; Erler JT; Gartland* A, 2011, 'Tumour-secreted lox mediates osteolytic bone metastases prior to metastatic tumour cell colonisation', Bone, vol. 48, pp. S21 - S21, http://dx.doi.org/10.1016/j.bone.2010.10.054
    Journal articles | 2010
    Graham HK; Hodson NW; Hoyland JA; Millward-Sadler SJ; Garrod D; Scothern A; Griffiths CEM; Watson REB; Cox TR; Erler JT; Trafford AW; Sherratt MJ, 2010, 'Tissue section AFM: In situ ultrastructural imaging of native biomolecules', Matrix Biology, vol. 29, pp. 254 - 260, http://dx.doi.org/10.1016/j.matbio.2010.01.008
    Journal articles | 2009
    Erler JT; Bennewith KL; Cox TR; Lang G; Bird D; Koong A; Le QT; Giaccia AJ, 2009, 'Hypoxia-Induced Lysyl Oxidase Is a Critical Mediator of Bone Marrow Cell Recruitment to Form the Premetastatic Niche', Cancer Cell, vol. 15, pp. 35 - 44, http://dx.doi.org/10.1016/j.ccr.2008.11.012

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Our research focuses on how the ECM and ECM remodelling influences cancer progression, therapy response, and metastatic dissemination in solid tumours. In particular we work on the role of post-translational modification of the ECM, including Lysyl Oxidase (LOX) and Lysyl Oxidase Like (LOXL) family members. Our work looks at the importance of these changes in regulating both the biochemical and biomechanical properties of the ECM during fibrosis, cancer progression and metastasis. These ECM changes lead to significant alterations in cellular response to drugs, and we work to understand how we can use dual therapy approaches to improve drug efficacy. Our research includes multidisciplinary, international collaborative projects working with biologists, physicists, engineers and clinicians to study disease progression at a systems biology level.