Ms Tien Nga Lam
Senior Technical Officer
- PhD in Biotechnology, UNSW Sydney:
Research & Enterprise
Recombinant Products Facility
I am a biotechnologist specialising in recombinant protein engineering and the development of functional biomaterials. My PhD research focused on the intersection of protein nanotechnology and bioprocessing, specifically exploring how molecular chaperones like prefoldin can be harnessed to scaffold complex enzyme assemblies and fabricate conductive metalloprotein nanowires.
In my current capacity as a Senior Technical Officer at the Recombinant Products Facility (RPF), I lead the end-to-end production of plasmid DNA (pDNA), managing upstream fementation and downstream purification workflows. I collaborate extensively with interdisciplinary research groups to translate complex biotechnological concepts into scalable, high-precision laboratory processes.
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Location
Room 320 Biological Sciences North (D26)
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- 2019: Recipient of UNSW Scientia PhD scholarship for PhD programme in Australia.
- 2022: The best poster award presented at Annual EMBL Australia Posrtgraduate Symposium
- Upstream Processing (USP): Management of high-density microbial fermentation and cell culture workflows. I specialize in media optimization, growth kinetics monitoring, and the implementation of scale-up strategies to maximize volumetric productivity.
- Downstream Processing (DSP): Design of sophisticated purification pipelines, including primary recovery (cell lysis/clarification) and multi-step chromatography (affinity, IEX, SEC). I focus on optimizing yield and purity while maintaining the structural integrity of complex biomolecules.
- Quality Control & In-Process Control (IPC): Implementation of rigorous QC protocols to ensure product consistency. This includes real-time monitoring of process parameters and end-product validation using HPLC/FPLC, gel electrophoresis, mass photometry and prometheus.