Dr Timothy James Williams
Senior Research Associate

Dr Timothy James Williams

Science
Biotech & Biomolecular Science

Professional Experience

  • 2006 - present: Senior, Research Associate (UNSW) Sydney, Australia
  • 2002 - 2006: Postdoctoral Researcher (IOWA State University) Ames, Iowa, USA
  • 2004 - 2006: Researcher (Ames Laboratory - US Department of Energy) Ames, Iowa, USA
  • 2000 - 2002: USDA/ARS Researcher (US Department of Agriculture) Ames, Iowa, USA
  • 1998 - 2000:  Postdoctoral Researcher (University of Connecticut) Storrs, Connecticut, USA
  • 1993 - 1997: PhD Student (School of Microbiology & Immunology - UNSW) Sydney, Australia

Research Contribution

My principal interest is investigating how microorganisms adapt to the environment at a molecular level.  In this endeavor, I have integrated biochemical, genomic and proteomic techniques to study microbial adaptation, especially in marine environments.  My research has allowed me to gain insights into several important topics relevant to microbial ecology, including: 

Reconstruction of Antarctic microbial ecosystems in the Southern Ocean, in both summer and winter seasons.  My metaproteomic and metagenomic research has identified pathways for carbon flow in the dark Antarctic winter, carried out by archaea and bacteria.  Through extensive analysis of metaproteome and metagenomic data I have identified preferred carbon and nitrogen sources for Southern Ocean microorganisms, and identified key proteins involved in carbon fixation, nitrification, and sulfur cycling. This is especially important in the Southern Ocean, given its global importance as a carbon sink, and the fact that during the polar winter the ocean around Antarctic receives very little illumination.  During the winter months, when photosynthesis by algae is impaired, dark autotrophic pathways carried out by archaea and bacteria are extremely important.

Mechanisms of cold adaptation in archaea, using the model psychrophile Methanococcoides burtonii, a resident of Ace Lake.  This has allowed the discovery of novel proteins involved in cold adaptation (cell surface proteins, molecular chaperones), as well as how cold temperatures influence the utilization of nutrients for growth.  This was the first study to describe cold stress in a psychrophilic archaeon, by exposing M. burtonii to conditions below its natural growth temperature.   

The adaptation of bacteria to oligotrophic marine environments, using the model oligotroph Sphingopyxis alaskensis.  This has elucidated how this oligotrophic bacterium is adapted to nutrient limitation, especially with regards to its carbon and nitrogen metabolism.

Phone
(+61 2) 9385 8704
Location
Room: G14A, Ground Floor, Samuels Building

Publications

  • Book Chapters | 2015
    Dr Timothy James Williams
    Lauro FM; Williams TJ, 2015, 'Abyssal Zone, Metagenomics of', in Encyclopedia of Metagenomics, Springer US, pp. 1 - 6, http://dx.doi.org/10.1007/978-1-4899-7475-4_33
    Book Chapters | 2013
    Dr Timothy James Williams
    Lauro FM; Williams TJ, 2013, 'Abyssal Zone, Metagenomics of', in Encyclopedia of Metagenomics, Springer New York, pp. 1 - 6, http://dx.doi.org/10.1007/978-1-4614-6418-1_33-6
    Book Chapters |
    Dr Timothy James Williams
    Frankel RB; Williams TJ; Bazylinski DA, 'Magneto-Aerotaxis', in Microbiology Monographs, Springer Berlin Heidelberg, pp. 1 - 24, http://dx.doi.org/10.1007/7171_2006_036
    Book Chapters |
    Dr Timothy James Williams
    Bazylinski DA; Williams TJ, 'Ecophysiology of Magnetotactic Bacteria', in Microbiology Monographs, Springer Berlin Heidelberg, pp. 37 - 75, http://dx.doi.org/10.1007/7171_038
  • Journal articles | 2021
    Dr Timothy James Williams
    Nayfach S; Roux S; Seshadri R; Udwary D; Varghese N; Schulz F; Wu D; Paez-Espino D; Chen IM; Huntemann M; Palaniappan K; Ladau J; Mukherjee S; Reddy TBK; Nielsen T; Kirton E; Faria JP; Edirisinghe JN; Henry CS; Jungbluth SP; Chivian D; Dehal P; Wood-Charlson EM; Arkin AP; Tringe SG; Visel A; Abreu H; Acinas SG; Allen E; Allen MA; Alteio LV; Andersen G; Anesio AM; Attwood G; Avila-Magaña V; Badis Y; Bailey J; Baker B; Baldrian P; Barton HA; Beck DAC; Becraft ED; Beller HR; Beman JM; Bernier-Latmani R; Berry TD; Bertagnolli A; Bertilsson S; Bhatnagar JM; Bird JT; Blanchard JL; Blumer-Schuette SE; Bohannan B; Borton MA; Brady A; Brawley SH; Brodie J; Brown S; Brum JR; Brune A; Bryant DA; Buchan A; Buckley DH; Buongiorno J; Cadillo-Quiroz H; Caffrey SM; Campbell AN; Campbell B; Carr S; Carroll JL; Cary SC; Cates AM; Cattolico RA; Cavicchioli R; Chistoserdova L; Coleman ML; Constant P; Conway JM; Mac Cormack WP; Crowe S; Crump B; Currie C; Daly R; DeAngelis KM; Denef V; Denman SE; Desta A; Dionisi H; Dodsworth J; Dombrowski N; Donohue T; Dopson M; Driscoll T; Dunfield P; Dupont CL; Dynarski KA; Edgcomb V; Edwards EA; Elshahed MS; Figueroa I, 2021, 'A genomic catalog of Earth’s microbiomes', Nature Biotechnology, vol. 39, pp. 499 - 509, http://dx.doi.org/10.1038/s41587-020-0718-6
    Journal articles | 2021
    Dr Timothy James Williams
    Taylor JA; Palladino G; Wemheuer B; Steinert G; Sipkema D; Williams TJ; Thomas T, 2021, 'Phylogeny resolved, metabolism revealed: functional radiation within a widespread and divergent clade of sponge symbionts', ISME Journal, vol. 15, pp. 503 - 519, http://dx.doi.org/10.1038/s41396-020-00791-z
    Journal articles | 2021
    Dr Timothy James Williams
    Nayfach S; Roux S; Seshadri R; Udwary D; Varghese N; Schulz F; Wu D; Paez-Espino D; Chen IM; Huntemann M; Palaniappan K; Ladau J; Mukherjee S; Reddy TBK; Nielsen T; Kirton E; Faria JP; Edirisinghe JN; Henry CS; Jungbluth SP; Chivian D; Dehal P; Wood-Charlson EM; Arkin AP; Tringe SG; Visel A; Abreu H; Acinas SG; Allen E; Allen MA; Andersen G; Anesio AM; Attwood G; Avila-Magaña V; Badis Y; Bailey J; Baker B; Baldrian P; Barton HA; Beck DAC; Becraft ED; Beller HR; Beman JM; Bernier-Latmani R; Berry TD; Bertagnolli A; Bertilsson S; Bhatnagar JM; Bird JT; Blumer-Schuette SE; Bohannan B; Borton MA; Brady A; Brawley SH; Brodie J; Brown S; Brum JR; Brune A; Bryant DA; Buchan A; Buckley DH; Buongiorno J; Cadillo-Quiroz H; Caffrey SM; Campbell AN; Campbell B; Carr S; Carroll JL; Cary SC; Cates AM; Cattolico RA; Cavicchioli R; Chistoserdova L; Coleman ML; Constant P; Conway JM; Mac Cormack WP; Crowe S; Crump B; Currie C; Daly R; Denef V; Denman SE; Desta A; Dionisi H; Dodsworth J; Dombrowski N; Donohue T; Dopson M; Driscoll T; Dunfield P; Dupont CL; Dynarski KA; Edgcomb V; Edwards EA; Elshahed MS; Figueroa I; Flood B; Fortney N; Fortunato CS, 2021, 'Publisher Correction: A genomic catalog of Earth’s microbiomes (Nature Biotechnology, (2021), 39, 4, (499-509), 10.1038/s41587-020-0718-6)', Nature Biotechnology, vol. 39, pp. 520, http://dx.doi.org/10.1038/s41587-020-00769-4
    Journal articles | 2021
    Dr Timothy James Williams
    Nayfach S; Roux S; Seshadri R; Udwary D; Varghese N; Schulz F; Wu D; Paez-Espino D; Chen IM; Huntemann M; Palaniappan K; Ladau J; Mukherjee S; Reddy TBK; Nielsen T; Kirton E; Faria JP; Edirisinghe JN; Henry CS; Jungbluth SP; Chivian D; Dehal P; Wood-Charlson EM; Arkin AP; Tringe SG; Visel A; Abreu H; Acinas SG; Allen E; Allen MA; Alteio LV; Andersen G; Anesio AM; Attwood G; Avila-Magaña V; Badis Y; Bailey J; Baker B; Baldrian P; Barton HA; Beck DAC; Becraft ED; Beller HR; Beman JM; Bernier-Latmani R; Berry TD; Bertagnolli A; Bertilsson S; Bhatnagar JM; Bird JT; Blanchard JL; Blumer-Schuette SE; Bohannan B; Borton MA; Brady A; Brawley SH; Brodie J; Brown S; Brum JR; Brune A; Bryant DA; Buchan A; Buckley DH; Buongiorno J; Cadillo-Quiroz H; Caffrey SM; Campbell AN; Campbell B; Carr S; Carroll JL; Cary SC; Cates AM; Cattolico RA; Cavicchioli R; Chistoserdova L; Coleman ML; Constant P; Conway JM; Mac Cormack WP; Crowe S; Crump B; Currie C; Daly R; DeAngelis KM; Denef V; Denman SE; Desta A; Dionisi H; Dodsworth J; Dombrowski N; Donohue T; Dopson M; Driscoll T; Dunfield P; Dupont CL; Dynarski KA; Edgcomb V; Edwards EA; Elshahed MS; Figueroa I, 2021, 'Author Correction: A genomic catalog of Earth’s microbiomes (Nature Biotechnology, (2021), 39, 4, (499-509), 10.1038/s41587-020-0718-6)', Nature Biotechnology, vol. 39, pp. 521, http://dx.doi.org/10.1038/s41587-021-00898-4
    Journal articles | 2021
    Dr Timothy James Williams
    Montgomery K; Williams TJ; Brettle M; Berengut JF; Zhang E; Zaugg J; Hugenholtz P; Ferrari BC, 2021, 'Persistence and resistance: survival mechanisms of Candidatus Dormibacterota from nutrient-poor Antarctic soils', Environmental Microbiology, http://dx.doi.org/10.1111/1462-2920.15610
    Journal articles | 2021
    Dr Timothy James Williams
    Shen L; Liu Y; Allen MA; Xu B; Wang N; Williams TJ; Wang F; Zhou Y; Liu Q; Cavicchioli R, 2021, 'Linking genomic and physiological characteristics of psychrophilic Arthrobacter to metagenomic data to explain global environmental distribution', Microbiome, vol. 9, pp. 136, http://dx.doi.org/10.1186/s40168-021-01084-z
    Journal articles | 2021
    Dr Timothy James Williams
    Williams TJ; Allen MA; Ivanova N; Huntemann M; Haque S; Hancock AM; Brazendale S; Cavicchioli R, 2021, 'Genome Analysis of a Verrucomicrobial Endosymbiont With a Tiny Genome Discovered in an Antarctic Lake', Frontiers in Microbiology, vol. 12, http://dx.doi.org/10.3389/fmicb.2021.674758
    Journal articles | 2021
    Dr Timothy James Williams
    Ji M; Williams TJ; Montgomery K; Wong HL; Zaugg J; Berengut JF; Bissett A; Chuvochina M; Hugenholtz P; Ferrari BC, 2021, 'Candidatus Eremiobacterota, a metabolically and phylogenetically diverse terrestrial phylum with acid-tolerant adaptations', ISME Journal, http://dx.doi.org/10.1038/s41396-021-00944-8
    Journal articles | 2020
    Dr Timothy James Williams
    Yeow M; Liu F; Ma R; Williams TJ; Riordan SM; Zhang L, 2020, 'Analyses of energy metabolism and stress defence provide insights into Campylobacter concisus growth and pathogenicity', Gut Pathogens, vol. 12, http://dx.doi.org/10.1186/s13099-020-00349-6
    Journal articles | 2020
    Dr Timothy James Williams
    Panwar P; Allen MA; Williams TJ; Hancock AM; Brazendale S; Bevington J; Roux S; Páez-Espino D; Nayfach S; Berg M; Schulz F; Chen IMA; Huntemann M; Shapiro N; Kyrpides NC; Woyke T; Eloe-Fadrosh EA; Cavicchioli R, 2020, 'Influence of the polar light cycle on seasonal dynamics of an Antarctic lake microbial community', Microbiome, vol. 8, pp. 116, http://dx.doi.org/10.1186/s40168-020-00889-8
    Journal articles | 2019
    Dr Timothy James Williams
    Williams TJ; Allen MA; Liao Y; Raftery MJ; Cavicchioli R, 2019, 'Sucrose metabolism in haloarchaea: Reassessment using genomics, proteomics, and metagenomics', Applied and Environmental Microbiology, vol. 85, http://dx.doi.org/10.1128/AEM.02935-18
    Journal articles | 2019
    Dr Timothy James Williams
    Hamm JN; Erdmann S; Eloe-Fadrosh EA; Angeloni A; Zhong L; Brownlee C; Williams TJ; Barton K; Carswell S; Smith MA; Brazendale S; Hancock AM; Allen MA; Raftery MJ; Cavicchioli R, 2019, 'Unexpected host dependency of Antarctic Nanohaloarchaeota', Proceedings of the National Academy of Sciences of the United States of America, vol. 116, pp. 14661 - 14670, http://dx.doi.org/10.1073/pnas.1905179116
    Journal articles | 2018
    Dr Timothy James Williams
    Tschitschko B; Erdmann S; DeMaere MZ; Roux S; Panwar P; Allen MA; Williams TJ; Brazendale S; Hancock AM; Eloe-Fadrosh EA; Cavicchioli R, 2018, 'Genomic variation and biogeography of Antarctic haloarchaea', Microbiome, vol. 6, http://dx.doi.org/10.1186/s40168-018-0495-3
    Journal articles | 2017
    Dr Timothy James Williams
    Williams TJ; Liao Y; Ye J; Kuchel RP; Poljak A; Raftery MJ; Cavicchioli R, 2017, 'Cold adaptation of the Antarctic haloarchaea Halohasta litchfieldiae and Halorubrum lacusprofundi', Environmental Microbiology, vol. 19, pp. 2210 - 2227, http://dx.doi.org/10.1111/1462-2920.13705
    Journal articles | 2017
    Dr Timothy James Williams
    Williams TJ; Allen M; Tschitschko B; Cavicchioli R, 2017, 'Glycerol metabolism of haloarchaea', Environmental Microbiology, vol. 19, pp. 864 - 877, http://dx.doi.org/10.1111/1462-2920.13580
    Journal articles | 2017
    Dr Timothy James Williams
    Bazylinski DA; Morillo V; Lefèvre CT; Viloria N; Dubbels BL; Williams TJ, 2017, 'Endothiovibrio diazotrophicus gen. nov., sp. nov., a novel nitrogen-fixing, sulfur-oxidizing gammaproteobacterium isolated from a salt marsh', International Journal of Systematic and Evolutionary Microbiology, vol. 67, pp. 1491 - 1498, http://dx.doi.org/10.1099/ijsem.0.001743
    Journal articles | 2016
    Dr Timothy James Williams
    Taha ; Siddiqui KS; Campanaro S; Najnin T; Deshpande N; Williams TJ; Aldrich-Wright J; Wilkins M; Curmi PMG; Cavicchioli R, 2016, 'Single TRAM domain RNA-binding proteins in Archaea: functional insight from Ctr3 from the Antarctic methanogen Methanococcoides burtonii', Environmental microbiology, vol. 18, pp. 2810 - 2824, http://dx.doi.org/10.1111/1462-2920.13229
    Journal articles | 2016
    Dr Timothy James Williams
    Liao Y; Williams TJ; Ye J; Charlesworth J; Burns BP; Poljak A; Raftery MJ; Cavicchioli R, 2016, 'Morphological and proteomic analysis of biofilms from the Antarctic archaeon, Halorubrum lacusprofundi', Scientific Reports, vol. 6, http://dx.doi.org/10.1038/srep37454
    Journal articles | 2016
    Dr Timothy James Williams
    Liao Y; Williams TJ; Walsh JC; Ji M; Poljak A; Curmi PMG; Duggin IG; Cavicchioli R, 2016, 'Developing a genetic manipulation system for the Antarctic archaeon, Halorubrum lacusprofundi: Investigating acetamidase gene function', Scientific Reports, vol. 6, http://dx.doi.org/10.1038/srep34639
    Journal articles | 2016
    Dr Timothy James Williams
    Tschitschko B; Williams TJ; Allen MA; Zhong L; Raftery MJ; Cavicchioli R, 2016, 'Ecophysiological distinctions of haloarchaea from a hypersaline Antarctic lake determined using metaproteomics.', Appl Environ Microbiol, vol. 82, pp. 3165 - 3173, http://dx.doi.org/10.1128/AEM.00473-16
    Journal articles | 2015
    Dr Timothy James Williams
    Tschitschko B; Williams TJ; Allen MA; Páez-Espino D; Kyrpides N; Zhong L; Raftery MJ; Cavicchioli R, 2015, 'Antarctic archaea–virus interactions: metaproteome-led analysis of invasion, evasion and adaptation', The ISME Journal, vol. 9, pp. 2094 - 2107, http://dx.doi.org/10.1038/ismej.2015.110
    Journal articles | 2014
    Dr Timothy James Williams
    Luk AWS; Williams TJ; Erdmann S; Thane Papke R; Cavicchioli R, 2014, 'Viruses of haloarchaea', Life, vol. 4, pp. 681 - 715, http://dx.doi.org/10.3390/life4040681
    Journal articles | 2014
    Dr Timothy James Williams
    Williams TJ; Cavicchioli R, 2014, 'Marine metaproteomics: Deciphering the microbial metabolic food web', Trends in Microbiology, vol. 22, pp. 248 - 260, http://dx.doi.org/10.1016/j.tim.2014.03.004
    Journal articles | 2014
    Dr Timothy James Williams
    Williams TJ; Allen MA; DeMaere MZ; Kyrpides NC; Tringe SG; Woyke T; Cavicchioli R, 2014, 'Microbial ecology of an Antarctic hypersaline lake: genomic assessment of ecophysiology among dominant haloarchaea', ISME JOURNAL, vol. 8, pp. 1645 - 1658, http://dx.doi.org/10.1038/ismej.2014.65
    Journal articles | 2013
    Dr Timothy James Williams
    Wilkins D; Lauro FM; Williams TJ; De Maere M; Brown MV; Hoffman JM; Andrews-Pfannkoch C; McQuaid J; Riddle M; Rintoul S; Cavicchioli R, 2013, 'Biogeographic partitioning of Southern Ocean microorganisms revealed by metagenomics', Environmental Microbiology, vol. 15, pp. 1318 - 1333, http://dx.doi.org/10.1111/1462-2920.12035
    Journal articles | 2013
    Dr Timothy James Williams
    Yau S; Lauro FM; Williams TJ; Brown MV; Demaere MZ; Rich J; Gibson J; Cavicchioli R, 2013, 'Metagenomic insights into strategies of carbon conservation and unusual sulfur biogeochemistry in a hypersaline Antarctic lake', ISME Journal, vol. 7, pp. 1944 - 1961, http://dx.doi.org/10.1038/ismej.2013.69
    Journal articles | 2013
    Dr Timothy James Williams
    Williams TJ; Wilkins D; Long E; Evans FF; De Maere MZ; Raftery MJ; Cavicchioli R, 2013, 'The role of planktonic Flavobacteria in processing algal organic matter in coastal East Antarctica revealed using metagenomics and metaproteomics', Environmental Microbiology, vol. 15, pp. 1302 - 1317, http://dx.doi.org/10.1111/1462-2920.12017
    Journal articles | 2013
    Dr Timothy James Williams
    Demaere MZ; Williams TJ; Allen MA; Brown MV; Gibson JAE; Rich J; Lauro FM; Dyall-Smith M; Davenport KW; Woyke T; Kyrpides NC; Tringe SG; Cavicchioli R, 2013, 'High level of intergenera gene exchange shapes the evolution of haloarchaea in an isolated Antarctic lake', Proceedings of the National Academy of Sciences of the United States of America, vol. 110, pp. 16939 - 16944, http://dx.doi.org/10.1073/pnas.1307090110
    Journal articles | 2013
    Dr Timothy James Williams
    Siddiqui KS; Williams TJ; Wilkins D; Yau S; Allen MA; Brown MV; Lauro FM; Cavicchioli R, 2013, 'Psychrophiles', Annual Review of Earth and Planetary Sciences, vol. 41, pp. 87 - 115, http://dx.doi.org/10.1146/annurev-earth-040610-133514
    Journal articles | 2013
    Dr Timothy James Williams
    Wilkins D; Yau S; Williams TJ; Allen MA; Brown MV; Demaere MZ; Lauro FM; Cavicchioli R, 2013, 'Key microbial drivers in Antarctic aquatic environments', FEMS Microbiology Reviews, vol. 37, pp. 303 - 335, http://dx.doi.org/10.1111/1574-6976.12007
    Journal articles | 2012
    Dr Timothy James Williams
    Williams TJ; Lefevre CT; Zhao W; Beveridge TJ; Bazylinski D, 2012, 'Magnetospira thiophila, gen. nov. sp. nov., a new marine magnetotactic bacterium that represents a novel lineage within the Rhodospirillaceae (Alphaproteobacteria).', International Journal of Systematic and Evolutionary Microbiology, vol. 62, pp. 2443 - 2450, http://dx.doi.org/10.1099/ijs.0.037697-0
    Journal articles | 2012
    Dr Timothy James Williams
    Williams TJ; Long E; Evans F; DeMaere M; Lauro FM; Raftery MJ; Ducklow H; Grzymski J; Murray A; Cavicchioli R, 2012, 'A metaproteomic assessment of winter and summer bacterioplankton from Antarctic Peninsula coastal surface waters', ISME Journal, vol. 6, pp. 1883 - 1900, http://dx.doi.org/10.1038/ismej.2012.28
    Journal articles | 2012
    Dr Timothy James Williams
    Bazylinski D; Williams TJ; Lefevre C; Berg RJ; Zhang CL; Bowser SS; Dean AJ; Beveridge TJ, 2012, 'Magnetococcus marinus gen. nov., sp. nov., a marine, magnetotactic bacterium that represents a novel lineage (Magnetococcaceae fam. nov.; Magnetococcales ord. nov.) at the base of the Alphaproteobacteria', International Journal of Systematic and Evolutionary Microbiology, vol. 63, pp. 801 - 808, http://dx.doi.org/10.1099/ijs.0.038927-0
    Journal articles | 2012
    Dr Timothy James Williams
    Bazylinski D; Williams TJ; Lefevre C; Trubitsyn D; Fang J; Beveridge TJ; Moskowitz BM; Ward B; Schubbe S; Dubbels BL; Simpson B, 2012, 'Magnetovibrio blakemorei, gen. nov. sp. nov., a new magnetotactic bacterium (Alphaproteobacteria: Rhodospirillaceae) isolated from a salt marsh.', International Journal of Systematic and Evolutionary Microbiology, vol. published online 14 September 2012, pp. 1824 - 1833, http://dx.doi.org/10.1099/ijs.0.044453-0
    Journal articles | 2012
    Dr Timothy James Williams
    Grzymski J; Riesenfeld C; Williams TJ; Dussaq A; Ducklow H; Erickson M; Cavicchioli R; Murray A, 2012, 'A metagenomic assessment of winter and summer bacterioplankton from Antarctic Peninsula coastal surface waters', ISME Journal, vol. 6, pp. 1901 - 1915, http://dx.doi.org/10.1038/ismej.2012.31
    Journal articles | 2012
    Dr Timothy James Williams
    Williams TJ; Willcox MD; Schneider RP, 2012, 'Interactions of ocular isolates of gram-negative bacteria with lactoferrin', Eye and Contact Lens, vol. 38, pp. 208 - 213, http://dx.doi.org/10.1097/ICL.0b013e318248292c
    Journal articles | 2011
    Dr Timothy James Williams
    Campanaro S; Williams TJ; Burg DW; De Francisci D; Treu L; Lauro FM; Cavicchioli R, 2011, 'Temperature-dependent global gene expression in the Antarctic archaeon, Methanococcoides burtonii.', Environmental Microbiology, vol. 13, pp. 2018 - 2038, http://dx.doi.org/10.1111/j.1462-2920.2010.02367.x
    Journal articles | 2011
    Dr Timothy James Williams
    Cavicchioli R; Charlton T; Ertan H; Mohd Omar S; Siddiqui KS; Williams TJ, 2011, 'Biotechnological uses of enzymes from psychrophiles', Microbial Biotechnology, vol. 4, pp. 449 - 460, http://dx.doi.org/10.1111/j.1751-7915.2011.00258.x
    Journal articles | 2011
    Dr Timothy James Williams
    Williams TJ; Lauro FM; Ertan H; Burg DW; Poljak A; Raftery MJ; Cavicchioli R, 2011, 'Defining the response of a microorganism to temperatures that span its complete growth temperature range (-2°C to 28°C) using multiplex quantitative proteomics', Environmental Microbiology, vol. 13, pp. 2186 - 2203, http://dx.doi.org/10.1111/j.1462-2920.2011.02467.x
    Journal articles | 2011
    Dr Timothy James Williams
    Pilak O; Harrop SJ; Siddiqui KS; Chong K; De Francisci D; Burg DW; Williams TJ; Cavicchioli R; Curmi PM, 2011, 'Chaperonins from an Antarctic archaeon are predominantly monomeric: open state crystal structure.', Environmental Microbiology, vol. 13, pp. 2232 - 2249, http://dx.doi.org/10.1111/j.1462-2920.2011.02477.x
    Journal articles | 2011
    Dr Timothy James Williams
    De Francisci D; Campanaro S; Kornfeld GD; Siddiqui KS; Williams TJ; Ertan H; Treu L; Pilak O; Lauro FM; Harrop SJ; Curmi PM; Cavicchioli R, 2011, 'The RNA polymerase subunits E/F from the Antarctic archaeon, Methanococcoides burtonii bind to specific classes of mRNA.', Environmental Microbiology, vol. 13, pp. 2039 - 2055, http://dx.doi.org/10.1111/j.1462-2920.2010.02385.x
    Journal articles | 2010
    Dr Timothy James Williams
    Williams TJ; Burg DW; Raftery MJ; Poljak A; Guilhaus M; Pilak O; Cavicchioli R, 2010, 'Global proteomic analysis of the insoluble, soluble, and supernatant fractions of the psychrophilic archaeon Methanococcoides burtonii. Part I: The effect of growth temperature', Journal of Proteome Research, vol. 9, pp. 640 - 652, http://dx.doi.org/10.1021/pr900509n
    Journal articles | 2010
    Dr Timothy James Williams
    Ting LL; Williams TJ; Cowley MJ; Lauro FM; Guilhaus M; Raftery MJ; Cavicchioli R, 2010, 'Cold adaptation in the marine bacterium, Sphingopyxis alaskensis assessed using quantitative proteomics.', Environmental Microbiology, vol. 12, pp. 2658 - 2676, http://dx.doi.org/10.1111/j.1462-2920.2010.02235.x
    Journal articles | 2010
    Dr Timothy James Williams
    Ng SC; De Maere M; Williams TJ; Lauro FM; Raftery MJ; Gibson J; Andrews-Pfannkoch C; Lewis M; Hoffman J; Thomas T; Cavicchioli R, 2010, 'Metaproteogenomic analysis of a dominant green sulfur bacterium from Ace Lake, Antarctica.', ISME Journal, vol. 4, pp. 1002 - 1019, http://dx.doi.org/10.1038/ismej.2010.28
    Journal articles | 2010
    Dr Timothy James Williams
    Williams TJ; Burg DW; Ertan H; Raftery MJ; Poljak A; Guilhaus M; Cavicchioli R, 2010, 'Global proteomic analysis of the insoluble, soluble, and supernatant fractions of the psychrophilic archaeon Methanococcoides burtonii. Part II: The effect of different methylated growth substrates', Journal of Proteome Research, vol. 9, pp. 653 - 663, http://dx.doi.org/10.1021/pr9005102
    Journal articles | 2010
    Dr Timothy James Williams
    Burg DW; Lauro FM; Williams TJ; Raftery MJ; Guilhaus M; Cavicchioli R, 2010, 'Analyzing the hydrophobic proteome of the Antarctic archaeon Methanococcoides burtonii using differential solubility fractionation', Journal of Proteome Research, vol. 9, pp. 664 - 676, http://dx.doi.org/10.1021/pr9007865
    Journal articles | 2009
    Dr Timothy James Williams
    Williams TJ; Ertan H; Ting LL; Cavicchioli R, 2009, 'Carbon and nitrogen substrate utilization in the marine bacterium Sphingopyxis alaskensis strain RB2256', ISME Journal, vol. 3, pp. 1036 - 1052, http://dx.doi.org/10.1038/ismej.2009.52
    Journal articles | 2009
    Dr Timothy James Williams
    Lauro FM; McDougald D; Thomas T; Williams TJ; Egan SG; Rice SA; Demaere MZ; Ting LL; Ertan H; Johnson J; Ferriera S; Lapidus A; Anderson IM; Kyrpides N; Munkf A; Detter C; Hang C; Brown M; Robb F; Kjelleberg S; Cavicchioli R, 2009, 'The genomic basis of trophic strategy in marine bacteria', Proceedings of the National Academy of Sciences of the United States of America, vol. 106, pp. 15527 - 15533, http://dx.doi.org/10.1073/pnas.0903507106
    Journal articles | 2009
    Dr Timothy James Williams
    Schubbe S; Williams TJ; Xie G; Kiss H; Brettin T; Martinez D; Ross C; Schuler D; Cox B; Nealson K; Bazylinski D, 2009, 'Complete genome sequence of the chemolithoautotrophic marine magnetotactic coccus strain MC-1', Applied and Environmental Microbiology, vol. 75, pp. 4835 - 4852, http://dx.doi.org/10.1128/AEM.02874-08
    Journal articles | 2009
    Dr Timothy James Williams
    Allen MA; Lauro FM; Williams TJ; Burg DW; Siddiqui KS; De Francisci D; Chong K; Pilak O; Chew H; De Maere M; Ting LL; Katrib M; Ng SC; Sowers KR; Galperin M; Anderson I; Ivanova N; Dalin E; Martinez MP; Lapidus A; Hauser L; Land MH; Thomas T; Cavicchioli R, 2009, 'The genome sequence of the psychrophilic archaeon, Methanococcoides burtonii: The role of genome evolution in cold adaptation', ISME Journal, vol. 3, pp. 1012 - 1035, http://dx.doi.org/10.1038/ismej.2009.45
    Journal articles | 2007
    Dr Timothy James Williams
    Prozorov R; Prozorov T; Mallapragada SK; Narasimhan B; Williams TJ; Bazylinski DA, 2007, 'Magnetic irreversibility and the Verwey transition in nanocrystalline bacterial magnetite', Physical Review B, vol. 76, http://dx.doi.org/10.1103/physrevb.76.054406
    Journal articles | 2007
    Dr Timothy James Williams
    Prozorov T; Mallapragada SK; Narasimhan B; Wang L; Palo P; Nilsen-Hamilton M; Williams TJ; Bazylinski DA; Prozorov R; Canfield PC, 2007, 'Protein-Mediated Synthesis of Uniform Superparamagnetic Magnetite Nanocrystals', Advanced Functional Materials, vol. 17, pp. 951 - 957, http://dx.doi.org/10.1002/adfm.200600448
    Journal articles | 2006
    Dr Timothy James Williams
    Williams TJ; Zhang CL; Scott JH; Bazylinski D, 2006, 'Evidence for Autotrophy via the Reverse Tricarboxylic Acid Cycle in the Marine Magnetotactic Coccus Strain MC-1', Applied and Environmental Microbiology, vol. 72, pp. 1322 - 1329, http://dx.doi.org/10.1128/AEM.72.2.1322-1329.2006
    Journal articles | 2004
    Dr Timothy James Williams
    Bazylinski DA; Dean AJ; Williams TJ; Long LK; Middleton SL; Dubbels BL, 2004, 'Chemolithoautotrophy in the marine, magnetotactic bacterial strains MV-1 and MV-2.', Archives of Microbiology, vol. 182, pp. 373 - 387
    Journal articles | 2003
    Dr Timothy James Williams
    Williams TJ; Schneider RP; Willcox MD, 2003, 'The effect of protein-coated contact lenses on the adhesion and viability of gram negative bacteria', Current Eye Research, vol. 27, pp. 227 - 235, http://dx.doi.org/10.1076/ceyr.27.4.227.16602
    Journal articles | 1998
    Dr Timothy James Williams
    Williams TJ; Willcox MDP; Schneider RP, 1998, 'Interactions of bacteria with contact lenses: The effect of soluble protein and carbohydrate on bacterial adhesion to contact lenses', Optometry and Vision Science, vol. 75, pp. 266 - 271, http://dx.doi.org/10.1097/00006324-199804000-00023
    Journal articles | 1998
    Dr Timothy James Williams
    Taylor RB; Willcox MD; Williams TJ; Verran J, 1998, 'Modulation of bacterial adhesion to hydrogel contact lenses by albumin', Optometry and Vision Science, vol. 75, pp. 23 - 29, http://dx.doi.org/10.1097/00006324-199801000-00021
    Journal articles | 1997
    Dr Timothy James Williams
    Williams TJ; Willcox MD; Schneider RP, 1997, 'The role of tear fluid in the growth of Gram-negative bacteria on contact lenses', Australian and New Zealand Journal of Ophthalmology, vol. 25, pp. S30 - S32
    Journal articles | 1996
    Dr Timothy James Williams
    Williams TJ; Willcox MDP; Schneider RP, 1996, 'The effect of protein deposits on bacterial adhesion to contact lenses', Investigative Ophthalmology and Visual Science, vol. 37

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