Dr Tsz Tin Yu

Dr Tsz Tin Yu

Associate Lecturer

B.Sc. UNSW, B.Sc.(Hons) UNSW, Ph.D. UNSW

Science
School of Chemistry

Tsz Tin Yu completed his Bachelor of Science in Chemistry and Pharmacology (with Distinction) at the University of New South Wales. He then continued his studies and completed his Bachelor of Science (Hons) in Chemistry (with first class honours) and Doctor of Philosophy in synthetic organic and medicinal chemistry under the supervision of Prof. Naresh Kumar at the University of New South Wales. After some research and teaching positions at the University of New South Wales, he was appointed as an associate lecturer in the School of Chemistry at the University of New South Wales

His research interests mainly focus on synthetic organic and medicinal chemistry, especially on the synthesis of bioactive compounds and the development of novel antimicrobial agents in response to antimicrobial resistance.
 

Phone
+61 2 9348 1738
Location
Room 113, Dalton Building
  • Journal articles | 2025
    Cheng Y; Yu TT; Bhadbhade M; Black DSC; Kumar N, 2025, 'Synthesis of Indoles through C2-C3 Bond Formation Using Lawesson’s Reagent', Journal of Organic Chemistry, http://dx.doi.org/10.1021/acs.joc.4c02922
    Journal articles | 2025
    Cheng Y; Yu TT; Olzomer EM; Beretta M; Katen A; Su J; Jones JP; Black DSC; Hoehn KL; Byrne FL; Kumar N, 2025, 'Design, synthesis and biological evaluation of naphthalene-1,4-dione analogues as anticancer agents', RSC Medicinal Chemistry, http://dx.doi.org/10.1039/d4md00987h
    Journal articles | 2025
    Cheng Y; Yu TT; Olzomer EM; Hoehn KL; Byrne FL; Kumar N; Black DS, 2025, 'Design, Synthesis, and Biological Evaluation of Naphthoquinone Salts as Anticancer Agents', Molecules, 30, pp. 1938 - 1938, http://dx.doi.org/10.3390/molecules30091938
    Journal articles | 2025
    Suresh D; Yu TT; Kuppusamy R; Sabir S; Das T; Black DSC; Willcox MDP; Kumar N, 2025, 'Novel cationic dihydropyrrol-2-one compounds as antimicrobial agents and quorum sensing inhibitors', Bioorganic and Medicinal Chemistry, 122, http://dx.doi.org/10.1016/j.bmc.2025.118137
    Journal articles | 2024
    Cheng Y; Jones JP; Yu TT; Olzomer EM; Su J; Katen A; Black DSC; Hart-Smith G; Childress ES; Beretta M; Wilkins MR; Mateos IA; Santos WL; Hoehn KL; Byrne FL; Kumar N, 2024, 'Corrigendum to “Design, synthesis and biological evaluation of glucose metabolism inhibitors as anticancer agents” [Bioorg. Chem. 151 (2024) 107665] (Bioorganic Chemistry (2024) 151, (S0045206824005704), (10.1016/j.bioorg.2024.107665))', Bioorganic Chemistry, 151, http://dx.doi.org/10.1016/j.bioorg.2024.107725
    Journal articles | 2024
    Cheng Y; Jones JP; Yu TT; Olzomer EM; Su J; Katen A; Black DSC; Hart-Smith G; Childress ES; Wilkins MR; Mateos IA; Santos WL; Hoehn KL; Byrne FL; Kumar N, 2024, 'Design, synthesis and biological evaluation of glucose metabolism inhibitors as anticancer agents', Bioorganic Chemistry, 151, http://dx.doi.org/10.1016/j.bioorg.2024.107665
    Journal articles | 2024
    Hong Z; Yu TT; Yasir M; Sara M; Black DSC; Willcox MDP; Kuppusamy R; Kumar N, 2024, 'Daidzein-Based Amphiphilic Small Molecular Antimicrobial Peptidomimetics as Novel Antimicrobial Agents with Anti-Biofilm Activity', ChemistrySelect, 9, http://dx.doi.org/10.1002/slct.202400502
    Journal articles | 2024
    Sara M; Yasir M; Kalaiselvan P; Hui A; Kuppusamy R; Kumar N; Chakraborty S; Yu TT; Wong EHH; Molchanova N; Jenssen H; Lin JS; Barron AE; Willcox M, 2024, 'The activity of antimicrobial peptoids against multidrug-resistant ocular pathogens', Contact Lens and Anterior Eye, 47, http://dx.doi.org/10.1016/j.clae.2024.102124
    Journal articles | 2024
    Sun J; Yu TT; Mirabediny M; Lee M; Jones A; O'Carroll DM; Manefield MJ; Kumar PV; Pickford R; Ramadhan ZR; Bhattacharyya SK; Åkermark B; Das B; Kumar N, 2024, 'Soluble metal porphyrins - Zero-valent zinc system for effective reductive defluorination of branched per and polyfluoroalkyl substances (PFASs)', Water Research, 258, http://dx.doi.org/10.1016/j.watres.2024.121803
    Journal articles | 2023
    Gadde S; Kleynhans A; Holien JK; Bhadbhade M; Nguyen PLD; Mittra R; Yu TT; Carter DR; Parker MW; Marshall GM; Cheung BB; Kumar N, 2023, 'Pyrimido[1,2-a]benzimidazoles as inhibitors of oncoproteins ubiquitin specific protease 5 and MYCN in the childhood cancer neuroblastoma', Bioorganic Chemistry, 136, http://dx.doi.org/10.1016/j.bioorg.2023.106462
    Journal articles | 2023
    Kuppusamy R; Yasir M; Yu TT; Voli F; Vittorio O; Miller MJ; Lewis P; Black DSC; Willcox M; Kumar N, 2023, 'Tuning the Anthranilamide Peptidomimetic Design to Selectively Target Planktonic Bacteria and Biofilm', Antibiotics, 12, pp. 585, http://dx.doi.org/10.3390/antibiotics12030585
    Journal articles | 2023
    Mirabediny M; Sun J; Yu TT; Åkermark B; Das B; Kumar N, 2023, 'Effective PFAS degradation by electrochemical oxidation methods-recent progress and requirement', Chemosphere, 321, http://dx.doi.org/10.1016/j.chemosphere.2023.138109
    Journal articles | 2023
    Mirabediny M; Yu TT; Sun J; Lee M; O'Carroll DM; Manefield MJ; Åkermark B; Das B; Kumar N, 2023, 'Fast reductive defluorination of branched perfluorooctane sulfonic acids by cobalt phthalocyanine: electrochemical studies and mechanistic insights', Environmental Science: Water Research and Technology, 10, pp. 216 - 227, http://dx.doi.org/10.1039/d3ew00612c
    Journal articles | 2023
    Sabir S; Das T; Kuppusamy R; Yu TT; Willcox MD; Black DSC; Kumar N, 2023, 'Novel quinazolinone disulfide analogues as pqs quorum sensing inhibitors against Pseudomonas aeruginosa', Bioorganic Chemistry, 130, pp. 106226, http://dx.doi.org/10.1016/j.bioorg.2022.106226
    Journal articles | 2023
    Shandil S; Yu TT; Sabir S; Black DS; Kumar N, 2023, 'Synthesis of Novel Quinazolinone Analogues for Quorum Sensing Inhibition', Antibiotics, 12, http://dx.doi.org/10.3390/antibiotics12071227
    Journal articles | 2023
    Willcox MDP; Bahatheg G; Carnt N; Kalaiselvan P; Kumar N; Kuppusamy R; Rayamajhee B; Sara M; Stapleton F; Vijay AK; Yasir M; Yu TT, 2023, 'Biofilms and contact lenses: problems and solutions', Microbiology Australia, 44, pp. 96 - 99, http://dx.doi.org/10.1071/MA23027
    Journal articles | 2022
    Almohaywi B; Yu TT; Iskander G; Sabir S; Bhadbhade M; Black DS; Kumar N, 2022, 'Synthesis of Alkyne-Substituted Dihydropyrrolones as Bacterial Quorum-Sensing Inhibitors of Pseudomonas aeruginosa', Antibiotics, 11, http://dx.doi.org/10.3390/antibiotics11020151
    Journal articles | 2022
    Wu J; Yu TT; Kuppusamy R; Hassan MM; Alghalayini A; Cranfield CG; Willcox MDP; Black DS; Kumar N, 2022, 'Cholic Acid-Based Antimicrobial Peptide Mimics as Antibacterial Agents', International Journal of Molecular Sciences, 23, pp. 4623, http://dx.doi.org/10.3390/ijms23094623
    Journal articles | 2021
    Lizarme-Salas Y; Yu TT; de Bruin-Dickason C; Kumar N; Hunter L, 2021, 'Fluorinated quorum sensing inhibitors: enhancement of potency through conformational control', Organic and Biomolecular Chemistry, 19, pp. 9629 - 9636, http://dx.doi.org/10.1039/d1ob01649k
    Journal articles | 2021
    Sabir S; Yu TT; Kuppusamy R; Almohaywi B; Iskander G; Das T; Willcox MDP; Black DS; Kumar N, 2021, 'Novel seleno-and thio-urea-containing dihydropyrrol-2-one analogues as antibacterial agents', Antibiotics, 10, pp. 321, http://dx.doi.org/10.3390/antibiotics10030321
    Journal articles | 2021
    Suresh D; Sabir S; Yu TT; Wenholz D; Das T; Black DS; Kumar N, 2021, 'Natural product rottlerin derivatives targeting quorum sensing', Molecules, 26, http://dx.doi.org/10.3390/molecules26123745
    Journal articles | 2021
    Yu TT; Kuppusamy R; Yasir M; Hassan MM; Sara M; Ho J; Willcox MDP; Black DS; Kumar N, 2021, 'Polyphenylglyoxamide‐based amphiphilic small molecular peptidomimetics as antibacterial agents with anti‐biofilm activity', International Journal of Molecular Sciences, 22, pp. 7344, http://dx.doi.org/10.3390/ijms22147344
    Journal articles | 2020
    Yu TT; Bhadbhade M; Kuppusamy R; Black DSC; Kumar N, 2020, 'A facile synthesis of meta- and para-terphenylglyoxamide-based peptidomimetics', Tetrahedron Letters, 61, http://dx.doi.org/10.1016/j.tetlet.2020.152560
    Journal articles | 2020
    Yu TT; Kuppusamy R; Yasir M; Hassan MM; Alghalayini A; Gadde S; Deplazes E; Cranfield C; Willcox MDP; Black DS; Kumar N, 2020, 'Design, synthesis and biological evaluation of biphenylglyoxamide-based small molecular antimicrobial peptide mimics as antibacterial agents', International Journal of Molecular Sciences, 21, pp. 1 - 38, http://dx.doi.org/10.3390/ijms21186789
    Journal articles | 2019
    Almohaywi B; Yu TT; Iskander G; Chan DSH; Ho KKK; Rice S; Black DSC; Griffith R; Kumar N, 2019, 'Dihydropyrrolones as bacterial quorum sensing inhibitors', Bioorganic and Medicinal Chemistry Letters, 29, pp. 1054 - 1059, http://dx.doi.org/10.1016/j.bmcl.2019.03.004
    Journal articles | 2019
    Srinivasarao S; Nandikolla A; Nizalapur S; Yu TT; Pulya S; Ghosh B; Murugesan S; Kumar N; Chandra Sekhar KVG, 2019, 'Design, synthesis and biological evaluation of 1,2,3-triazole based 2-aminobenzimidazoles as novel inhibitors of LasR dependent quorum sensing in: Pseudomonas aeruginosa', RSC Advances, 9, pp. 29273 - 29292, http://dx.doi.org/10.1039/c9ra05059k
    Journal articles | 2018
    Almohaywi B; Iskander G; Yu TT; Bhadbhade M; Black DSC; Kumar N, 2018, 'Copper-mediated Chan-Evans-Lam N-arylation of 5-methylene-4-aryl-1,5-dihydro-2H-pyrrol-2-one derivatives', Tetrahedron Letters, 59, pp. 811 - 814, http://dx.doi.org/10.1016/j.tetlet.2018.01.039
    Journal articles | 2018
    Biswas NN; Iskander GM; Mielczarek M; Yu TT; Black DSC; Kumar N, 2018, 'Alkyne-Substituted Fimbrolide Analogues as Novel Bacterial Quorum-Sensing Inhibitors', Australian Journal of Chemistry, 71, pp. 708 - 715, http://dx.doi.org/10.1071/CH18194
    Journal articles | 2018
    Srinivasarao S; Nizalapur S; Yu TT; Wenholz DS; Trivedi P; Ghosh B; Rangan K; Kumar N; Gowri Chandra Sekhar KV, 2018, 'Design, Synthesis and Biological Evaluation of Triazole-Containing 2-Phenylindole and Salicylic Acid as Quorum Sensing Inhibitors Against Pseudomonas aeruginosa', ChemistrySelect, 3, pp. 9170 - 9180, http://dx.doi.org/10.1002/slct.201801622
    Journal articles | 2017
    Biswas NN; Yu TT; Kimyon Ö; Nizalapur S; Gardner CR; Manefield M; Griffith R; Black DSC; Kumar N, 2017, 'Synthesis of antimicrobial glucosamides as bacterial quorum sensing mechanism inhibitors', Bioorganic and Medicinal Chemistry, 25, pp. 1183 - 1194, http://dx.doi.org/10.1016/j.bmc.2016.12.024
    Journal articles | 2017
    Yu TT; Nizalapur S; Ho KKK; Yee E; Berry T; Cranfield CG; Willcox M; Black DSC; Kumar N, 2017, 'Design, Synthesis and Biological Evaluation of N-Sulfonylphenyl glyoxamide-Based Antimicrobial Peptide Mimics as Novel Antimicrobial Agents', ChemistrySelect, 2, pp. 3452 - 3461, http://dx.doi.org/10.1002/slct.201700336
  • Patents | 2021
    Kumar N; Willcox M; Nizalapur S; Black D; Yu TT; Kuppusamy R, 2021, Antimicrobial compounds, Patent No. United States 2021 pat no. 10988444

My research interests lie primarily in the area of synthetic organic and medicinal chemistry.

Research focuses:
- Development of novel methods for the synthesis of bioactive natural products and their derivatives

- Design and synthesis of novel class of antimicrobial agents with unique mechanism of action in response to antimicrobial resistance:
   - Small molecular antimicrobial peptidomimetics targeting bacterial cell membrane
   - Quorum sensing inhibitors targeting the bacterial AHL and PQS quorum sensing systems

- Development of dual action antimicrobial agents to target bacterial biofilms and reduce the chance of development of antimicrobial resistance
 

My Teaching

Dr. Yu currently teaches multiple courses (first year through to third year) across the School of Chemistry:
CHEM1011 Chemistry 1A: Atoms, Molecules and Energy – Tutor
CHEM1021 Chemistry 1B: Elements, Compounds and Life – Course coordinator and lecturer
CHEM1829 Biological Chemistry for Optometry Students – Lecturer
PHRM1021 Introductory Pharmaceutical Sciences – Lecturer
CHEM2021 Organic Chemistry: Mechanisms and Biomolecules – Lab supervisor
CHEM2051 Analytical Chemistry for the Pharmaceutical Sciences – Lab supervisor
CHEM3021 Organic Chemistry: Modern Synthetic Strategies – Lab supervisor
CHEM3051 Medicinal Organic Chemistry – Course coordinator, lecturer and lab supervisor