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Dr Vaibhao Janbandhu

Dr Vaibhao Janbandhu

Conjoint Lecturer
Medicine & Health
School of Clinical Medicine

Dr Vaibhao is a Postdoctoral Scientist at the Victor Chang Cardiac Research Institute, and a Conjoint Lecturer with the St Vincent's Clinical School.

My Research has focused on - the biology and origins of adult cardiac stromal cells, and understanding the molecular mechanisms of Heart Disease and Cardiac Regeneration. I am currently studying Cardiac Fibroblasts and how they function in the homeostasis and during disease.

 
Phone
+61 2 9295 8622
E-mail
v.janbandhu@victorchang.com.au
Location
Harvey Laboratory, Developmental & Stem Cell Biology Division Victor Chang Cardiac Research Institute Lowy Packer Building 405 Liverpool Street Darlinghurst NSW 2010
  • Journal articles | 2025
    Li JV; Kesteven S; Cheng D; Laden M; Omidkhoda F; Janbandhu V; Tallapragada V; Shewale B; Fneley M; Harvey RP; Cox CD, 2025, 'BPS2025 - PIEZO1 channel-mediated mechanotransduction as a driver of cardiac fibrosis', Biophysical Journal, 124, pp. 179a - 179a, http://dx.doi.org/10.1016/j.bpj.2024.11.1016
    Journal articles | 2025
    Li JV; Kesteven S; Cheng D; Laden M; Omidkhoda F; Janbandhu V; Tallapragada V; Shewale B; Fneley M; Harvey RP; Cox CD, 2025, 'BPS2025 - Piezo1 channel-mediated mechanotransduction as a driver of cardiac fibrosis', Biophysical Journal, 124, pp. 269a - 269a, http://dx.doi.org/10.1016/j.bpj.2024.11.1530
    Journal articles | 2025
    Monteiro JP; Saha D; Spiroski A-M; Mahesh S; Kaltzis P; Nadavallil A; Janbandhu V; Murray NJ; Severi F; De Pace AL; Sánchez-Esteban S; Rodor J; Beqqali A; Bennett M; Stewart K; Thomson A; Hadoke PWF; Markose D; Wilson-Kanamori JR; Henderson NC; O'Carroll D; Quertermous T; Harvey RP; Del Monte-Nieto G; Baker AH, 2025, 'Loss of conserved long non-coding RNA MIR503HG leads to altered NOTCH pathway signalling and left ventricular non-compaction cardiomyopathy.', Cardiovasc Res, http://dx.doi.org/10.1093/cvr/cvaf043
    Journal articles | 2024
    Janbandhu V; Tallapragada V; Li JV; Shewale B; Ghazanfar S; Patrick R; Cox CD; Harvey RP, 2024, 'Novel Mouse Model for Selective Tagging, Purification, and Manipulation of Cardiac Myofibroblasts', Circulation, 149, pp. 1931 - 1934, http://dx.doi.org/10.1161/CIRCULATIONAHA.123.067754
    Journal articles | 2024
    Patrick R; Janbandhu V; Tallapragada V; Tan SSM; McKinna EE; Contreras O; Ghazanfar S; Humphreys DT; Murray NJ; Tran YTH; Hume RD; Chong JJH; Harvey RP, 2024, 'Integration mapping of cardiac fibroblast single-cell transcriptomes elucidates cellular principles of fibrosis in diverse pathologies', Science Advances, 10, http://dx.doi.org/10.1126/sciadv.adk8501
    Journal articles | 2023
    Miranda AMA; Janbandhu V; Maatz H; Kanemaru K; Cranley J; Teichmann SA; Hübner N; Schneider MD; Harvey RP; Noseda M, 2023, 'Single-cell transcriptomics for the assessment of cardiac disease', Nature Reviews Cardiology, 20, pp. 289 - 308, http://dx.doi.org/10.1038/s41569-022-00805-7
    Journal articles | 2023
    Moradi Marjaneh M; Kirk EP; Patrick R; Alankarage D; Humphreys DT; Del Monte-Nieto G; Cornejo-Paramo P; Janbandhu V; Doan TB; Dunwoodie SL; Wong ES; Moran C; Martin ICA; Thomson PC; Harvey RP, 2023, 'Quantitative trait and transcriptome analysis of genetic complexity underpinning cardiac interatrial septation in mice using an advanced intercross line', eLife, 12, http://dx.doi.org/10.7554/eLife.83606
    Journal articles | 2023
    Voges HK; Foster SR; Reynolds L; Parker BL; Devilée L; Quaife-Ryan GA; Fortuna PRJ; Mathieson E; Fitzsimmons R; Lor M; Batho C; Reid J; Pocock M; Friedman CE; Mizikovsky D; Francois M; Palpant NJ; Needham EJ; Peralta M; Monte-Nieto GD; Jones LK; Smyth IM; Mehdiabadi NR; Bolk F; Janbandhu V; Yao E; Harvey RP; Chong JJH; Elliott DA; Stanley EG; Wiszniak S; Schwarz Q; James DE; Mills RJ; Porrello ER; Hudson JE, 2023, 'Vascular cells improve functionality of human cardiac organoids', Cell Reports, 42, http://dx.doi.org/10.1016/j.celrep.2023.112322
    Journal articles | 2023
    Zhou Z; Ma X; Lin Y; Cheng D; Bavi N; Secker GA; Li JV; Janbandhu V; Sutton DL; Scott HS; Yao M; Harvey RP; Harvey NL; Corry B; Zhang Y; Cox CD, 2023, 'MyoD-family inhibitor proteins act as auxiliary subunits of Piezo channels', Science, 381, pp. 799 - 804, http://dx.doi.org/10.1126/science.adh8190
    Journal articles | 2022
    Harvey RP; Patrick R; Janbandhu V; Contreras O, 2022, 'Cardiac fibroblast heterogeneity and dynamics through the lens of single-cell dual 'omics', Cardiovascular Research, 118, pp. 1380 - 1382, http://dx.doi.org/10.1093/cvr/cvac037
    Journal articles | 2022
    Janbandhu V; Martin EMMA; Chapman G; Dunwoodie SL; Harvey RP, 2022, 'Quantitative 3D analysis and visualization of cardiac fibrosis by microcomputed tomography', STAR Protocols, 3, http://dx.doi.org/10.1016/j.xpro.2021.101055
    Journal articles | 2022
    Janbandhu V; Tallapragada V; Patrick R; Li Y; Abeygunawardena D; Humphreys DT; Martin EMMA; Ward AO; Contreras O; Farbehi N; Yao E; Du J; Dunwoodie SL; Bursac N; Harvey RP, 2022, 'Hif-1a suppresses ROS-induced proliferation of cardiac fibroblasts following myocardial infarction', Cell Stem Cell, 29, pp. 281 - 297.e12, http://dx.doi.org/10.1016/j.stem.2021.10.009
    Journal articles | 2022
    Ward AO; Janbandhu V; Chapman G; Dunwoodie SL; Harvey RP, 2022, 'An image analysis protocol using CellProfiler for automated quantification of post-ischemic cardiac parameters', STAR Protocols, 3, http://dx.doi.org/10.1016/j.xpro.2021.101097
    Journal articles | 2021
    Farbehi N; Janbandhu V; Nordon RE; Harvey RP, 2021, 'Facs enrichment of total interstitial cells and fibroblasts from adult mouse ventricles', Bio-protocol, 11, http://dx.doi.org/10.21769/BioProtoc.4028
    Journal articles | 2020
    Patrick R; Humphreys DT; Janbandhu V; Oshlack A; Ho JWK; Harvey RP; Lo KK, 2020, 'Sierra: Discovery of differential transcript usage from polyA-captured single-cell RNA-seq data', Genome Biology, 21, http://dx.doi.org/10.1186/s13059-020-02071-7
    Journal articles | 2019
    Farbehi N; Patrick R; Dorison A; Xaymardan M; Janbandhu V; Wystub-Lis K; Ho JWK; Nordon RE; Harvey RP, 2019, 'Single-cell expression profiling reveals dynamic flux of cardiac stromal, vascular and immune cells in health and injury', eLife, 8, pp. e43882, http://dx.doi.org/10.7554/eLife.43882
    Journal articles | 2017
    Asli N; Xaymardan M; Patrick R; Farbehi N; Cornwell J; Forte E; Waardenberg A; Janbandhu V; Kesteven S; Chandrakanthan V; Malinowska H; Reinhard H; Schofield P; Christ D; Ahmed I; Bouveret R; Srivastava S; Mishra R; Dhawan J; Chong JJH; Nordon R; Macdonald P; Graham R; Feneley M; Harvey R, 2017, 'PDGFRα signaling in cardiac fibroblasts modulates quiescence, metabolism and self-renewal, and promotes anatomical and functional repair', , http://dx.doi.org/10.1101/225979
    Journal articles | 2015
    Forte E; Janbandhu V; Asli NS; Cornwell J; Abeygunawardena D; Xaymardan M; Harvey RP, 2015, 'Abstract 12: Physiological Role of Endogenous Adult Cardiac Colony-forming Unit Fibroblasts', Circulation Research, 117, http://dx.doi.org/10.1161/res.117.suppl_1.12
    Journal articles | 2014
    Janbandhu VC; Moik D; Fässler R, 2014, 'Cre recombinase induces DNA damage and tetraploidy in the absence of LoxP sites', Cell Cycle, 13, pp. 462 - 470, http://dx.doi.org/10.4161/cc.27271
    Journal articles | 2011
    Moik DV; Janbandhu VC; Fässler R, 2011, 'Loss of migfilin expression has no overt consequences on murine development and homeostasis', Journal of Cell Science, 124, pp. 414 - 421, http://dx.doi.org/10.1242/jcs.075960
    Journal articles | 2010
    Janbandhu VC; Singh AK; Mukherji A; Kumar V, 2010, 'p65 negatively regulates transcription of the cyclin E gene', Journal of Biological Chemistry, 285, pp. 17453 - 17464, http://dx.doi.org/10.1074/jbc.M109.058974
    Journal articles | 2009
    Mukherji A; Janbandhu VC; Kumar V, 2009, 'HBx protein modulates PI3K/Akt pathway to overcome genotoxic Stress-induced destabilization of cvclin Dl and arrest of cell cvcle', Indian Journal of Biochemistry and Biophysics, 46, pp. 37 - 44
    Journal articles | 2008
    Mukherji A; Janbandhu VC; Kumar V, 2008, 'GSK-3β-dependent destabilization of cyclin D1 mediates replicational stress-induced arrest of cell cycle', FEBS Letters, 582, pp. 1111 - 1116, http://dx.doi.org/10.1016/j.febslet.2008.02.068
    Journal articles | 2007
    Mukherji A; Janbandhu VC; Kumar V, 2007, 'HBx protein modulates PI3K/Akt pathway to overcome genotoxic stress-induced destabilization of cyclin D1 and arrest of cell cycle', Indian Journal of Geo-Marine Sciences, 46, pp. 37 - 44
    Journal articles | 2007
    Mukherji A; Janbandhu VC; Kumar V, 2007, 'HBx-dependent cell cycle deregulation involves interaction with cyclin E/A-cdk2 complex and destabilization of p27Kip1', Biochemical Journal, 401, pp. 247 - 256, http://dx.doi.org/10.1042/BJ20061091
  • Working Papers | 2019
    Patrick R; Humphreys D; Janbandhu V; Oshlack A; Ho JWK; Ho JWK; Harvey R; Lo K, 2019, Sierra: discovery of differential transcript usage from polyA-captured single-cell RNA-seq data, http://dx.doi.org10.1101/867309
  • Preprints | 2022
    Marjaneh MM; Kirk E; Patrick R; Alankerage D; Humphreys D; Del Monte-Nieto G; Cornejo-Paramo P; Janbandhu V; Doan T; Dunwoodie S; Wong E; Moran C; Martin ICA; Thomson P; Harvey R, 2022, Quantitative trait and transcriptome analysis of genetic complexity underpinning cardiac interatrial septation in mice using an advanced intercross line, http://dx.doi.org/10.1101/2022.10.31.514499
    Conference Abstracts | 2017
    Abeygunawardena D; Forte E; Janbandhu V; Xaymarden M; Harvey RP, 2017, 'COMPARISON OF CARDIAC MESENCHYMAL STEM CELLS DERIVED FROM ATRIA AND VENTRICLES', in JOURNAL OF GENE MEDICINE, WILEY, AUSTRALIA, Univ Technol Sydney, Sydney, Vol. 20, presented at Joint 10th Annual Scientific Meeting of the Australian-Gene-and-Cell-Therapy-Society (AGCTS) and Australasian-Society-for-Stem-Cell-Research (ASSCR), AUSTRALIA, Univ Technol Sydney, Sydney, 24 May 2017 - 26 May 2017, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000426528300045&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2015
    Forte E; Janbandhu V; Asli NS; Cornwell J; Abeygunawardena D; Xaymardan M; Harvey RP, 2015, 'Physiological Role of Endogenous Adult Cardiac Colony-forming Unit Fibroblasts', in CIRCULATION RESEARCH, LIPPINCOTT WILLIAMS & WILKINS, LA, New Orleans, presented at American-Stroke-Association/American-Heart-Association Basic Cardiovascular Sciences Scientific Sessions - Pathways to Cardiovascular Therapeutics, LA, New Orleans, 13 July 2015 - 16 July 2015, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000374552800012&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2015
    Harvey R; Asli N; Janbandhu V; Xaymardan M; Cornwell J; Nordon R; Waardenberg A; Forte E; Chandrakanthan V; Abeygunawardena D, 2015, 'CARDIAC STEM CELLS AND REGENERATION THERAPIES.', in TRANSPLANTATION, LIPPINCOTT WILLIAMS & WILKINS, AUSTRALIA, Lorne, Vol. 99, pp. S43 - S43, presented at 14th Transplantation Science Symposium of the Transplantation-Society (TSS), AUSTRALIA, Lorne, 11 November 2015 - 13 November 2015, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000368625900078&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2008
    Kumar V; Mukherji A; Janbandhu V, 2008, 'Abstract B78: The X protein of hepatitis B virus induces PI3K/Akt pathway to overcome gentoxic stress-related cyclin D1 degradation and growth arrest', in Cancer Prevention Research, American Association for Cancer Research (AACR), pp. B78 - B78, http://dx.doi.org/10.1158/1940-6207.prev-08-b78

Molecular Cardiovascular Biology and Cardiac Regeneration, Cardiac Fibrosis