Associate Professor Vincent   Murray
Honorary Associate Professor

Associate Professor Vincent Murray

Science
Biotech & Biomolecular Science

Research Contribution: Vincent Murray obtained his PhD from the National Institute for Medical Research in London. After post-doctoral fellowships at Princeton University and the Cancer Institute, Melbourne, Australia, in 1990 he was appointed as an academic at the University of NSW, Sydney, Australia.

His lab has concentrated on several areas including:- Next-generation DNA sequencing techniques; the DNA sequence specificity of drugs used as cancer chemotherapeutic agents; the development of more efficient anti-tumour agents based on cisplatin and bleomycin; and the interaction of UV light and ionising radiation with DNA.

His lab has made significant research contributions as shown by publication of over 100 papers in high profile international refereed journals. His H-index is 27.


1) The use of Next-generation DNA sequencing techniques to examine the cellular effects of anti-cancer drugs.

2) The DNA sequence specificity of drugs used as cancer chemotherapeutic agents;

3) The development of more efficient anti-tumour agents based on cisplatin and bleomycin;

4) The interaction of UV light and ionising radiation with DNA;

5) The influence of chromatin structure on the control of gene expression;

 

Professional Experience

  • Cancer Institute, Melbourne 1982-1990
  • Princeton University 1980-1982
Phone
(+61 2) 9385 2028
Location
Room: 420E (West end), D26 Biological Science North

Publications

  • Book Chapters | 1991
    Associate Professor Vincent Murray
    MARTIN RF; FITZGERALD DJ; MURRAY V; D'CUNHA G, 1991, 'BrUdR SENSITISATION: MECHANISMS OF STRAND CLEAVAGE BY UV-B', in Radiation Research: A Twentieth-century Perspective, Elsevier, pp. 419 - 419, http://dx.doi.org/10.1016/b978-0-12-168561-4.50185-2
    Book Chapters | 1991
    Associate Professor Vincent Murray
    Murray V; Martin RF, 1991, 'The Sequence Specificity of Ultraviolet Light Damage to DNA Containing Bromodeoxyuridine or Iododeoxyuridine', in Photobiology, Springer US, pp. 135 - 140, http://dx.doi.org/10.1007/978-1-4615-3732-8_16
    Book Chapters | 1990
    Associate Professor Vincent Murray
    Murray V, 1990, 'The sequence specificity of damage caused by [125I]-labelled Hoechst 33258 and UV / iodoHoechst 33258 in intact cells and in cloned sequences of purified DNA which differ by a small number of base substitutions', in The Jerusalem Symposia on Quantum Chemistry and Biochemistry, Springer Netherlands, pp. 67 - 73, http://dx.doi.org/10.1007/978-94-011-3728-7_5
  • Journal articles | 2021
    Associate Professor Vincent Murray
    Leung WY; Murray V, 2021, 'The influence of DNA methylation on the sequence specificity of UVB- and UVC-induced DNA damage', Journal of Photochemistry and Photobiology B: Biology, vol. 221, http://dx.doi.org/10.1016/j.jphotobiol.2021.112225
    Journal articles | 2021
    Associate Professor Vincent Murray
    Kava HW; Leung WY; Galea AM; Murray V, 2021, 'The DNA binding properties of 9-aminoacridine carboxamide Pt complexes', Bioorganic and Medicinal Chemistry, vol. 40, http://dx.doi.org/10.1016/j.bmc.2021.116191
    Journal articles | 2020
    Associate Professor Vincent Murray
    Nguyen GTH; Leung WY; Tran TN; Wang H; Murray V; Donald WA, 2020, 'Mechanism for the Binding of Netropsin to Hairpin DNA Revealed Using Nanoscale Ion Emitters in Native Mass Spectrometry', Analytical Chemistry, vol. 92, pp. 1130 - 1137, http://dx.doi.org/10.1021/acs.analchem.9b04209
    Journal articles | 2020
    Associate Professor Vincent Murray
    Murray V; Hardie ME; Gautam SD, 2020, 'Comparison of different methods to determine the DNA sequence preference of ionising radiation-induced DNA damage', Genes, vol. 11, http://dx.doi.org/10.3390/genes11010008
    Journal articles | 2019
    Associate Professor Vincent Murray
    Hardie ME; Murray V, 2019, 'The sequence preference of gamma radiation-induced DNA damage as determined by a polymerase stop assay', International Journal of Radiation Biology, vol. 95, pp. 1613 - 1626, http://dx.doi.org/10.1080/09553002.2019.1665216
    Journal articles | 2019
    Associate Professor Vincent Murray
    Hardie ME; Gautam SD; Murray V, 2019, 'The genome-wide sequence preference of ionising radiation-induced cleavage in human DNA', Molecular Biology Reports, vol. 46, pp. 3731 - 3745, http://dx.doi.org/10.1007/s11033-019-04815-6
    Journal articles | 2018
    Associate Professor Vincent Murray
    Johnson BW; Burgess MW; Murray V; Aldrich-Wright JR; Temple MD, 2018, 'The interactions of novel mononuclear platinum-based complexes with DNA', BMC Cancer, vol. 18, pp. 1284, http://dx.doi.org/10.1186/s12885-018-5194-8
    Journal articles | 2018
    Associate Professor Vincent Murray
    Chung LH; Murray V, 2018, 'An extended sequence specificity for UV-induced DNA damage', Journal of Photochemistry and Photobiology B: Biology, vol. 178, pp. 133 - 142, http://dx.doi.org/10.1016/j.jphotobiol.2017.10.034
    Journal articles | 2018
    Associate Professor Vincent Murray
    Murray V; Chen JK; Yang D; Shen B, 2018, 'The genome-wide sequence specificity of DNA cleavage by bleomycin analogues in human cells', Bioorganic and Medicinal Chemistry, vol. 26, pp. 4168 - 4178, http://dx.doi.org/10.1016/j.bmc.2018.07.006
    Journal articles | 2018
    Associate Professor Vincent Murray
    Khoe CV; Chung LH; Murray V, 2018, 'The sequence specificity of UV-induced DNA damage in a systematically altered DNA sequence', Journal of Photochemistry and Photobiology B: Biology, vol. 183, pp. 88 - 100, http://dx.doi.org/10.1016/j.jphotobiol.2018.04.023
    Journal articles | 2018
    Associate Professor Vincent Murray
    Murray V; Chen JK; Chung LH, 2018, 'The interaction of the metallo-glycopeptide anti-tumour drug bleomycin with DNA', International Journal of Molecular Sciences, vol. 19, http://dx.doi.org/10.3390/ijms19051372
    Journal articles | 2018
    Associate Professor Vincent Murray
    Gautam SD; Hardie ME; Murray V, 2018, 'The Sequence Preference of Gamma-Radiation-Induced Damage in End-Labeled DNA after Heat Treatment', Radiation Research, vol. 189, pp. 238 - 250, http://dx.doi.org/10.1667/RR14886.1
    Journal articles | 2018
    Associate Professor Vincent Murray
    Hardie ME; Murray V, 2018, 'The sequence preference of DNA cleavage by T4 endonuclease VII', Biochimie, vol. 146, pp. 1 - 13, http://dx.doi.org/10.1016/j.biochi.2017.11.002
    Journal articles | 2018
    Associate Professor Vincent Murray
    Leung WY; Chung LH; Kava HW; Murray V, 2018, 'RecBCD (Exonuclease V) is inhibited by DNA adducts produced by cisplatin and ultraviolet light', Biochemical and Biophysical Research Communications, vol. 495, pp. 666 - 671, http://dx.doi.org/10.1016/j.bbrc.2017.11.060
    Journal articles | 2017
    Associate Professor Vincent Murray
    Chen JK; Yang D; Shen B; Murray V, 2017, 'Bleomycin analogues preferentially cleave at the transcription start sites of actively transcribed genes in human cells', International Journal of Biochemistry and Cell Biology, vol. 85, pp. 56 - 65, http://dx.doi.org/10.1016/j.biocel.2017.02.001
    Journal articles | 2017
    Associate Professor Vincent Murray
    Gautam SD; Chen JK; Murray V, 2017, 'The DNA sequence specificity of bleomycin cleavage in a systematically altered DNA sequence', Journal of Biological Inorganic Chemistry, vol. 22, pp. 881 - 892, http://dx.doi.org/10.1007/s00775-017-1466-z
    Journal articles | 2016
    Associate Professor Vincent Murray
    Chen JK; Murray V, 2016, 'The determination of the DNA sequence specificity of bleomycin-induced abasic sites', Journal of Biological Inorganic Chemistry, vol. 21, pp. 395 - 406, http://dx.doi.org/10.1007/s00775-016-1349-8
    Journal articles | 2016
    Associate Professor Vincent Murray
    Johnson BW; Murray V; Temple MD, 2016, 'Characterisation of the DNA sequence specificity, cellular toxicity and cross-linking properties of novel bispyridine-based dinuclear platinum complexes', BMC Cancer, vol. 16, http://dx.doi.org/10.1186/s12885-016-2368-0
    Journal articles | 2016
    Associate Professor Vincent Murray
    Chen JK; Yang D; Shen B; Neilan BA; Murray V, 2016, 'Zorbamycin has a different DNA sequence selectivity compared with bleomycin and analogues', Bioorganic and Medicinal Chemistry, vol. 24, pp. 6094 - 6101, http://dx.doi.org/10.1016/j.bmc.2016.09.072
    Journal articles | 2016
    Associate Professor Vincent Murray
    Kava HW; Murray V, 2016, 'CpG methylation increases the DNA binding of 9-aminoacridine carboxamide Pt analogues', Bioorganic and Medicinal Chemistry, vol. 24, pp. 4701 - 4710, http://dx.doi.org/10.1016/j.bmc.2016.08.011
    Journal articles | 2016
    Associate Professor Vincent Murray
    Murray V; Chen JK; Tanaka MM, 2016, 'The genome-wide DNA sequence specificity of the anti-tumour drug bleomycin in human cells', Molecular Biology Reports, vol. 43, pp. 639 - 651, http://dx.doi.org/10.1007/s11033-016-3998-7
    Journal articles | 2016
    Associate Professor Vincent Murray
    Chung LH; Murray V, 2016, 'The mitochondrial DNA sequence specificity of the anti-tumour drug bleomycin using end-labeled DNA and capillary electrophoresis and a comparison with genome-wide DNA sequencing', Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, vol. 1008, pp. 87 - 97, http://dx.doi.org/10.1016/j.jchromb.2015.11.029
    Journal articles | 2016
    Associate Professor Vincent Murray
    Hardie ME; Kava HW; Murray V, 2016, 'Cisplatin Analogues with an Increased Interaction with DNA: Prospects for Therapy.', Curr Pharm Des, vol. 22, pp. 6645 - 6664, http://dx.doi.org/10.2174/1381612822666160831101529
    Journal articles | 2015
    Associate Professor Vincent Murray
    Murray V; Taylor CB; Gero AM; Lutze-Mann LH, 2015, 'The influence of p53 status on the cytotoxicity of fluorinated pyrimidine L-nucleosides', Chemico-Biological Interactions, vol. 240, pp. 102 - 109, http://dx.doi.org/10.1016/j.cbi.2015.08.010
    Journal articles | 2015
    Associate Professor Vincent Murray
    Murray V, 2015, 'The frequency of poly(G) tracts in the human genome and their use as a sensor of DNA damage', Computational Biology and Chemistry, vol. 54, pp. 13 - 17, http://dx.doi.org/10.1016/j.compbiolchem.2014.11.006
    Journal articles | 2014
    Associate Professor Vincent Murray
    Murray V; Chen JK; Galea AM, 2014, 'The anti-tumor drug bleomycin preferentially cleaves at the transcription start sites of actively transcribed genes in human cells', Cellular and Molecular Life Sciences, vol. 71, pp. 1505 - 1512, http://dx.doi.org/10.1007/s00018-013-1456-4
    Journal articles | 2014
    Associate Professor Vincent Murray
    Kava HW; Galea AM; Md. Jamil F; Feng Y; Murray V, 2014, 'Characterising the atypical 5′-CG DNA sequence specificity of 9-aminoacridine carboxamide Pt complexes', Journal of Biological Inorganic Chemistry, vol. 19, pp. 997 - 1007, http://dx.doi.org/10.1007/s00775-014-1144-3
    Journal articles | 2014
    Associate Professor Vincent Murray
    Murray V; Chen JK; Galea AM, 2014, 'The potential of acridine carboxamide Pt complexes as anti-cancer agents: A review', Anti-Cancer Agents in Medicinal Chemistry, vol. 14, pp. 695 - 705, http://dx.doi.org/10.2174/18715206113136660361
    Journal articles | 2014
    Associate Professor Vincent Murray
    Murray V; Chen JK; Galea AM, 2014, 'Enhanced DNA repair of bleomycin-induced 3'-phosphoglycolate termini at the transcription start sites of actively transcribed genes in human cells', Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, vol. 769, pp. 93 - 99, http://dx.doi.org/10.1016/j.mrfmmm.2014.06.006
    Journal articles | 2013
    Associate Professor Vincent Murray
    Nguyen HT; Galea AM; Murray V, 2013, 'The interaction of cisplatin with a human telomeric DNA sequence containing seventeen tandem repeats', Bioorganic and Medicinal Chemistry Letters, vol. 23, pp. 1041 - 1045, http://dx.doi.org/10.1016/j.bmcl.2012.12.021
    Journal articles | 2013
    Associate Professor Vincent Murray
    Nguyen TVT; Chen JK; Murray V, 2013, 'Bleomycin DNA damage: Anomalous mobility of 3'-phosphoglycolate termini in an automated capillary DNA sequencer', Journal of Chromatography B - Analytical Technologies in the Biomedical and Life Sciences, vol. 913-914, pp. 113 - 122, http://dx.doi.org/10.1016/j.jchromb.2012.11.029
    Journal articles | 2013
    Associate Professor Vincent Murray
    Nguyen TVT; Murray V, 2013, 'The electrophoretic mobility of DNA fragments differing by a single 3'-terminal nucleotide in an automated capillary DNA sequencer', Biomedical Chromatography, vol. 27, pp. 390 - 395, http://dx.doi.org/10.1002/bmc.2804
    Journal articles | 2012
    Associate Professor Vincent Murray
    Paul M; Murray V, 2012, 'Use of an automated capillary DNA sequencer to investigate the interaction of cisplatin with telomeric DNA sequences', Biomedical Chromatography, vol. 26, pp. 350 - 354, http://dx.doi.org/10.1002/bmc.1664
    Journal articles | 2012
    Associate Professor Vincent Murray
    Murray V; Nguyen TVT; Chen JK, 2012, 'The use of automated sequencing techniques to investigate the sequence selectivity of DNA-damaging agents.', Chemical Biology and Drug Design, vol. 80, pp. 1 - 8, http://dx.doi.org/10.1111/j.1747-0285.2012.01379.x
    Journal articles | 2012
    Associate Professor Vincent Murray
    Nguyen H; Murray V, 2012, 'The DNA sequence specificity of bleomycin cleavage in telomeric sequences in human cells.', Journal of Biological Inorganic Chemistry, vol. 17, pp. 1209 - 1215, http://dx.doi.org/10.1007/s00775-012-0934-8
    Journal articles | 2012
    Associate Professor Vincent Murray
    Nguyen TVT; Murray V, 2012, 'Human telomeric DNA sequences are a major target for the anti-tumour drug, Bleomycin.', Journal of Biological Inorganic Chemistry, vol. 17, pp. 1 - 9, http://dx.doi.org/10.1007/s00775-011-0818-3
    Journal articles | 2012
    Associate Professor Vincent Murray
    Murray V; Kandasamy N, 2012, 'The sequence specificity of the anti-tumour drug, Cisplatin, in telomeric DNA sequences compared with consecutive guanine DNA sequences', Anti-Cancer Agents in Medicinal Chemistry, vol. 12, pp. 177 - 181, http://dx.doi.org/10.2174/187152012800228742
    Journal articles | 2012
    Associate Professor Vincent Murray
    Lung MS; Zhang N; Murray V, 2012, 'Site-directed mutagenesis of human papillomavirus 18 promoter elements and tissue-specific expression in cervical carcinoma cells.', Virus Genes, vol. 44, pp. 395 - 402, http://dx.doi.org/10.1007/s11262-012-0723-z
    Journal articles | 2012
    Associate Professor Vincent Murray
    Murray V; Campbell HM; Gero AM, 2012, 'Plasmodium falciparum: The potential of the cancer chemotherapeutic agent cisplatin and its analogues as anti-malarials.', Experimental Parasitology, vol. 132, pp. 440 - 443, http://dx.doi.org/10.1016/j.exppara.2012.09.004
    Journal articles | 2012
    Associate Professor Vincent Murray
    Murray V; Galea AM, 2012, 'Gene expression profiling of the cancer chemotherapeutic agent, Cisplatin, compared with its ineffective isomer, Transplatin.', Journal of Computer Science and Systems Biology, vol. 5, pp. 37, http://dx.doi.org/10.4172/0974-7230.S1.02
    Journal articles | 2012
    Associate Professor Vincent Murray
    Nguyen HTQ; Murray V, 2012, 'The DNA sequence specificity of bleomycin cleavage in telomeric sequences in human cells', Journal of Biological Inorganic Chemistry, pp. 1 - 7, http://dx.doi.org/10.1007/s00775-012-0934-8
    Journal articles | 2011
    Associate Professor Vincent Murray
    Lung ; Lung ; Murray V, 2011, 'The use of a human papillomavirus 18 promoter for tissue specific expression in cervical carcinoma cells.', Cellular and Molecular Biology Letters, vol. 16, pp. 477 - 492, http://dx.doi.org/10.2478/s11658-011-0018-8
    Journal articles | 2011
    Associate Professor Vincent Murray
    Paul M; Murray V, 2011, 'The sequence selectivity of DNA-targeted 9-aminoacridine cisplatin analogues in a telomere-containing DNA sequence.', Journal of Biological Inorganic Chemistry, vol. 16, pp. 735 - 743, http://dx.doi.org/10.1007/s00775-011-0774-y
    Journal articles | 2011
    Associate Professor Vincent Murray
    Murray V; Campbell HM; Gero AM, 2011, 'Plasmodium falciparum: DNA sequence specificity of cisplatin and cisplatin analogues', Experimental Parasitology, vol. 128, pp. 396 - 400, http://dx.doi.org/10.1016/j.exppara.2011.05.002
    Journal articles | 2010
    Associate Professor Vincent Murray
    Galea AM; Murray V, 2010, 'The influence of chromatin structure on DNA damage induced by nitrogen mustards and cisplatin analogues.', Chemical Biology and Drug Design, vol. 75, pp. 578 - 589, http://dx.doi.org/10.1111/j.1747-0285.2010.00969.x
    Journal articles | 2010
    Associate Professor Vincent Murray
    Carland M; Grannas MJ; Cairns MJ; Roknic VJ; Denny WA; David McFadyen W; Murray V, 2010, 'Substituted 9-aminoacridine-4-carboxamides tethered to platinum(II)diamine complexes: Chemistry, cytotoxicity and DNA sequence selectivity.', Journal of Inorganic Biochemistry, vol. 104, pp. 815 - 819, http://dx.doi.org/10.1016/j.jinorgbio.2010.03.011
    Journal articles | 2010
    Associate Professor Vincent Murray
    Holmes RJ; Abrahams B; Murray V; Denny WA; David McFadyen W, 2010, 'A 2D hydrogen-bonded network constructed from large organic dications.', Journal of Molecular Structure, vol. 975, pp. 186 - 189, http://dx.doi.org/10.1016/j.molstruc.2010.04.020
    Journal articles | 2010
    Associate Professor Vincent Murray
    Murray V, 2010, 'Nucleosomes and Cisplatin.', Chemistry and biology, vol. 17, pp. 1271 - 1272, http://dx.doi.org/10.1016/j.chembiol.2010.12.002
    Journal articles | 2009
    Associate Professor Vincent Murray
    Cairns MJ; Carland M; David McFadyen W; Denny WA; Murray VM, 2009, 'The DNA sequence selectivity of maltolato-containing cisplatin analogues in purified plasmid DNA and in intact human cells', Journal of Inorganic Biochemistry, vol. 103, pp. 1151 - 1155, http://dx.doi.org/10.1016/j.jinorgbio.2009.06.001
    Journal articles | 2008
    Associate Professor Vincent Murray
    Galea AM; Murray VM, 2008, 'The anti-tumour agent, Cisplatin, and its clinically ineffective isomer, Transplatin, produce unique gene expression profiles in human cells', Cancer Informatics, vol. 6, pp. 315 - 355
    Journal articles | 2006
    Associate Professor Vincent Murray
    Carland M; Abrahams B; Rede T; Stephenson J; Murray VM; Denny WA; Mcfadyen WD, 2006, 'Syntheses and structural studies of platinum(II) complexes of O-methylselenomethionine and related ligands', Inorganica Chimica Acta, vol. 359, pp. 3252 - 3256, http://dx.doi.org/10.1016/j.ica.2006.03.008
    Journal articles | 2006
    Associate Professor Vincent Murray
    White JM; Mcfadyen WD; Carland M; Denny WA; Murray VM, 2006, '9,9a-diphenyl-1,3,4,6,7,9a-hexahydro-2H-pyrazino[1,2-a]pyrimidine at 130 K', ACTA Crystallographica Section E - Structure Reports Online, vol. 62, pp. O1846 - O1848, http://dx.doi.org/10.1107/S1600536806012463
    Journal articles | 2005
    Associate Professor Vincent Murray
    Carland M; Tan KJ; White JM; Stephenson J; Murray VM; Denny WA; Mcfadyen WD, 2005, 'Syntheses, crystal structure and cytotoxicity of diamine platinum(II) complexes containing maltol', Journal of Inorganic Biochemistry, vol. 99, pp. 1738 - 1743, http://dx.doi.org/10.1016/j.jinorgbio.2005.06.003
    Journal articles | 2005
    Associate Professor Vincent Murray
    Temple MD; Murray VM, 2005, 'Footprinting the `essential regulatory region` of the retinoblastoma gene promoter in intact human cells', International Journal of Biochemistry and Cell Biology, vol. 37, pp. 665 - 678, http://dx.doi.org/10.1016/j.biocel.2004.09.005
    Journal articles | 2005
    Associate Professor Vincent Murray
    Carland M; Abrahams B; Denny WA; Murray VM; Mcfadyen WD, 2005, 'Hydrogen-bonded networks from novel platinum(II) dimers', CrystEngComm, vol. 7, pp. 701 - 705, http://dx.doi.org/10.1039/b511536a
    Journal articles | 2004
    Associate Professor Vincent Murray
    Temple MD; Freebody J; Murray VM, 2004, 'Genomic and phylogenetic footprinting at the epsilon-globin silencer region in intact human cells', Biochimica et Biophysica ACTA, vol. 1678, pp. 126 - 134, http://dx.doi.org/10.1016/j.bbaexp.2004.03.003
    Journal articles | 2004
    Associate Professor Vincent Murray
    Davies NP; Freebody J; Murray VM, 2004, 'Chromatin structure at the flanking regions of the human beta-globin locus control region DNase I hypersensitive site-2: proposed nucleosome positioning by DNA-binding proteins including GATA-1', Biochimica et Biophysica ACTA, vol. 1679, pp. 201 - 213, http://dx.doi.org/10.1016/j.bbaexp.2004.04.002
    Journal articles | 2003
    Associate Professor Vincent Murray
    Robillard MS; Davies NP; van der Marel GA; van Boom JH; Reedijk J; Murray VM, 2003, 'The interaction of peptide-tethered platinum(II) complexes with DNA', Journal of Inorganic Biochemistry, vol. 96, pp. 331 - 338, http://dx.doi.org/10.1016/S0162-0134(03)00180-6
    Journal articles | 2002
    Associate Professor Vincent Murray
    Temple MD; Mcfadyen WD; Holmes RJ; Denny WA; Murray VM, 2002, 'The interaction of DNA-targeted 9-aminoacridine-4-carboxamide platinum complexes with DNA in intact human cells', Biochim Biophys ACTA, vol. 1574, pp. 223 - 230, http://dx.doi.org/10.1016/S0167-4781(01)00365-7
    Journal articles | 2002
    Associate Professor Vincent Murray
    Attema JL; Reeves R; Murray V; Levichkin I; Temple MD; Tremethick DJ; Shannon AF, 2002, 'The human IL-2 gene promoter can assemble a positioned nucleosome that becomes remodeled upon T cell activation', JOURNAL OF IMMUNOLOGY, vol. 169, pp. 2466 - 2476, http://dx.doi.org/10.4049/jimmunol.169.5.2466
    Journal articles | 2002
    Associate Professor Vincent Murray
    Galea AM; Murray V, 2002, 'The interaction of cisplatin and analogues with DNA in reconstituted chromatin', Biochimica et Biophysica Acta - Gene Structure and Expression, vol. 1579, pp. 142 - 152, http://dx.doi.org/10.1016/S0167-4781(02)00535-3
    Journal articles | 2002
    Associate Professor Vincent Murray
    Murray VM; Tremethick D; Temple MD, 2002, 'The proximal promoter of the human interleukin-2 gene is occupied by a positional nucleosome that becomes remodelled upon T-cell activation', Journal of Immunology, vol. 169, pp. 2466 - 2476
    Journal articles | 2002
    Associate Professor Vincent Murray
    Galea AM; Murray VM, 2002, 'Cisplatin preferentially targets the linker region of the nucleosome', Biochim Biophys ACTA, vol. 1579, pp. 142 - 152
    Journal articles | 2001
    Associate Professor Vincent Murray
    Holmes RJ; Mckeage M; Murray VM; Denny WA; Mcfadyen DW, 2001, 'cis-Dichloroplatinum(II) complexes tethered to 9-aminoacridine-4-carboxamides: synthesis and action in resistant cell lines in vitro', Journal of Inorganic Biochemistry, vol. 85, pp. 209 - 217, http://dx.doi.org/10.1016/S0162-0134(01)00188-X
    Journal articles | 2001
    Associate Professor Vincent Murray
    Whittaker J; McFadyen WD; Baguley BC; Murray V, 2001, 'The interaction of DNA-targeted platinum phenanthridinium complexes with DNA in human cells', Anti-Cancer Drug Design, vol. 16, pp. 81 - 89
    Journal articles | 2001
    Associate Professor Vincent Murray
    Kim A; Murray VM, 2001, 'Chromatin structure at the 3`-boundary of the human B-globin locus control region hypersensitive site-2', International Journal of Biochemistry and Cell Biology, vol. 33, pp. 1183 - 1192, http://dx.doi.org/10.1016/S1357-2725(01)00087-5
    Journal articles | 2001
    Associate Professor Vincent Murray
    Whittaker JK; Mcfadyen DW; Baguley BC; Murray VM, 2001, 'The interaction of DNA-targeted platinum phenanthridinium complexes with DNA in human cells', Anti-Cancer Drug Design, vol. 16, pp. 1 - 9
    Journal articles | 2000
    Associate Professor Vincent Murray
    Kim A; Murray VM, 2000, 'A large `footprint` at the boundary of the human beta-globin locus control region hypersensitive site-2', International Journal of Biochemistry and Cell Biology, vol. 32, pp. 695 - 702, http://dx.doi.org/10.1016/S1357-2725(00)00023-6
    Journal articles | 2000
    Associate Professor Vincent Murray
    Davies NP; Hardman LC; Murray VM, 2000, 'The effect of chromatin structure on cisplatin damage in intact human cells', Nucleic Acids Research, vol. 28, pp. 2954 - 2958
    Journal articles | 2000
    Associate Professor Vincent Murray
    Temple MD; Mcfadyen DW; Holmes RJ; Denny WA; Murray VM, 2000, 'Interaction of cisplatin and DNA-targeted 9-aminoacridine platinum complexes with DNA', Biochemistry, vol. 39, pp. 5593 - 5599, http://dx.doi.org/10.1021/bi9922143
    Journal articles | 2000
    Associate Professor Vincent Murray
    Murray VM, 2000, 'A survey of the sequence-specific interaction of damaging agents with DNA: emphasis on antitumor agents', Progress in Nucleic Acid Research and Molecular Biology, vol. 63, pp. 367 - 415
    Journal articles | 2000
    Associate Professor Vincent Murray
    Davies NP; Murray VM, 2000, 'Shortened protocol for terminal deoxynucleotidyl transferase-dependent PCR', BioTechniques, vol. 29, pp. 1168 - 1172
    Journal articles | 1999
    Associate Professor Vincent Murray
    Temple MD; Cairns MJ; Kim A; Murray VM, 1999, 'Protein-DNA footprinting of the human epsilon-globin promoter in human intact cells using nitrogen mustard analogues and other DNA-damaging agents', Biochimica et Biophysica ACTA - Bioenergetics, vol. 1445, pp. 245 - 256, http://dx.doi.org/10.1016/S0167-4781(99)00057-3
    Journal articles | 1998
    Associate Professor Vincent Murray
    Whittaker JK; Mcfadyen DW; Wickham G; Wakelin L; Murray VM, 1998, 'The interaction of DNA-targeted platinum phenanthridinium complexes with DNA', Nucleic Acids Research, vol. 26, pp. 3933 - 3939
    Journal articles | 1998
    Associate Professor Vincent Murray
    Murray VM; Whittaker JK; Mcfadyen DW, 1998, 'DNA sequence selectivity of cisplatin analogues in intact human cells', Chemico - Biological Interactions, vol. 110, pp. 27 - 37, http://dx.doi.org/10.1016/S0009-2797(97)00110-5
    Journal articles | 1998
    Associate Professor Vincent Murray
    Cairns MJ; Murray VM, 1998, 'The DNA sequence specificity of hedamycin damage determined by ligation-mediated PCR and linear amplification', Biochemistry and Molecular Biology International, vol. 46, pp. 267 - 275
    Journal articles | 1998
    Associate Professor Vincent Murray
    Cairns MJ; Murray VM, 1998, 'Detection of protein-DNA interactions at beta-globin gene cluster in intact human cells utilizing hedamycin as DNA-damaging agent', DNA and Cell Biology, vol. 17, pp. 325 - 333, http://dx.doi.org/10.1089/dna.1998.17.325
    Journal articles | 1997
    Associate Professor Vincent Murray
    Temple MD; Cairns MJ; Denny WA; Murray VM, 1997, 'Protein-DNA interactions in the human beta-globin locus control region hypersensitive site-2 as revealed by four nitrogen mustards', Nucleic Acids Research, vol. 25, pp. 3255 - 3260, http://dx.doi.org/10.1093/nar/25.16.3255
    Journal articles | 1997
    Associate Professor Vincent Murray
    Murray VM; Whittaker JK; Temple MD; Mcfadyen DW, 1997, 'Interaction of 11 cisplatin analogues with DNA: characteristic pattern of damage with monofunctional analogues', Biochimica et Biophysica ACTA - Gene Structure and Expression, vol. 1354, pp. 261 - 271, http://dx.doi.org/10.1016/S0167-4781(97)00087-0
    Journal articles | 1997
    Associate Professor Vincent Murray
    Hardman LC; Murray VM, 1997, 'Use of an automated sequencer to determine the sequence specificity of DNA damage', Biochemistry and Molecular Biology International, vol. 42, pp. 349 - 359
    Journal articles | 1996
    Associate Professor Vincent Murray
    Murray VM; Matias C; Mcfadyen WD; Wickham G, 1996, 'The influence of linker chain length on the sequence specificity of DNA damage by n-bromoalkylphenenthridinium bromides in plasmid DNA and in intact human cells', Biochimica et Biophysica ACTA, vol. 1305, pp. 79 - 86, http://dx.doi.org/10.1016/0167-4781(95)00211-1
    Journal articles | 1996
    Associate Professor Vincent Murray
    Cairns MJ; Murray V, 1996, 'Influence of chromatin structure on bleomycin-DNA interactions at base pair resolution in the human β-globin gene cluster', Biochemistry, vol. 35, pp. 8753 - 8760, http://dx.doi.org/10.1021/bi9600207
    Journal articles | 1995
    Associate Professor Vincent Murray
    Prakash AS; Moore A; Murray VM; Matias C; Mcfadyen WD; Wickham G, 1995, 'Comparison of the sequence selectivity of the DNA-alkylating pluramycin antitumour antibiotics DC92-B and hedamycin', Chemico - Biological Interactions, vol. 95, pp. 17 - 28, http://dx.doi.org/10.1016/0009-2797(94)03341-2
    Journal articles | 1995
    Associate Professor Vincent Murray
    Murray V; Moore AG; Matias C; Wickham G, 1995, 'The interaction of hedamycin and DC92-B in a sequence selective manner with DNA in intact human cells', BBA - Gene Structure and Expression, vol. 1261, pp. 195 - 200, http://dx.doi.org/10.1016/0167-4781(94)00236-V
    Journal articles | 1995
    Associate Professor Vincent Murray
    Murray VM; Moore A; Matias C; Wickham G, 1995, 'The influence of chromatin structure on the sequence specific interaction of hedamycin and DC92-B with DNA in intact human cells', Biochimica et Biophysica ACTA - Bioenergetics, vol. 1261, pp. 195 - 200
    Journal articles | 1994
    Associate Professor Vincent Murray
    Cairns MJ; Murray V, 1994, 'Comparison of the sequence specificity of cis-diamminedichloroplatinum (II) damage in guanine- and 7-deazaguanine-containing DNA', BBA - Gene Structure and Expression, vol. 1218, pp. 315 - 321, http://dx.doi.org/10.1016/0167-4781(94)90183-X
    Journal articles | 1994
    Associate Professor Vincent Murray
    Murray V; Martin RF, 1994, 'Ultraviolet light-induced cleavage of DNA in presence of iodoHoechst 33258: The sequence specificity of the reaction', Nucleic Acids Research, vol. 22, pp. 506 - 513, http://dx.doi.org/10.1093/nar/22.3.506
    Journal articles | 1994
    Associate Professor Vincent Murray
    Cairns MJ; Murray V, 1994, 'Dideoxy genomic sequencing of a single-copy mammalian gene using more than two hundred cycles of linear amplification', BioTechniques, vol. 17, pp. 910 - 913+914
    Journal articles | 1994
    Associate Professor Vincent Murray
    Murray V; Monchawin C, 1994, 'A polymerase chain reaction on human alphoid DNA produces a characteristic ladder of bands', Biochemistry and Molecular Biology International, vol. 34, pp. 323 - 327
    Journal articles | 1994
    Associate Professor Vincent Murray
    Holliday R; Murray V, 1994, 'Specificity in splicing', BioEssays, vol. 16, pp. 771 - 774, http://dx.doi.org/10.1002/bies.950161013
    Journal articles | 1993
    Associate Professor Vincent Murray
    Murray V; Monchawin C; Cairns MJ; England PR; Leigh D; McDonald BL, 1993, 'Detection of polymorphisms using thermal cycling with a single oligonucleotide on a DNA sequencing gel', Human Mutation, vol. 2, pp. 118 - 122, http://dx.doi.org/10.1002/humu.1380020210
    Journal articles | 1993
    Associate Professor Vincent Murray
    England PR; Murray V, 1993, 'Sequence-Specific DNA Damage Using Iodine-125-Labeled Antisense Oligonucleotides', Antisense Research and Development, vol. 3, pp. 219 - 224, http://dx.doi.org/10.1089/ard.1993.3.219
    Journal articles | 1993
    Associate Professor Vincent Murray
    Murray V; Monchawin C; England PR, 1993, 'The determination of the sequences present in the shadow bands of a dinucleotide repeat PCR', Nucleic Acids Research, vol. 21, pp. 2395 - 2398, http://dx.doi.org/10.1093/nar/21.10.2395
    Journal articles | 1992
    Associate Professor Vincent Murray
    Murray V; Motyka H; England PR; Wickham G; Lee HH; Denny WA; McFadyen WD, 1992, 'An Investigation of the Sequence-Specific Interaction of Cis-Diamminedichloroplatinum(Ii) and Four Analogs, Including two Acridine-Tethered Complexes with DNA Inside Human Cells', Biochemistry, vol. 31, pp. 11812 - 11817, http://dx.doi.org/10.1021/bi00162a020
    Journal articles | 1992
    Associate Professor Vincent Murray
    Murray V; Motyka H; England PR; Wickham G; Lee HH; Denny WA; McFadyen WD, 1992, 'The use of Taq DNA polymerase to determine the sequence specificity of DNA damage caused by cis-diamminedichloroplatinum(II), acridine-tethered platinum(II) diammine complexes or two analogues', Journal of Biological Chemistry, vol. 267, pp. 18805 - 18809
    Journal articles | 1992
    Associate Professor Vincent Murray
    Murray V; Monchawin C; England PR; Neilan BA; Leigh D; Mcdonald BL, 1992, 'Direct PCR Sequencing of Dystrophin Polymorphic CACA Alleles after Purification to Remove Shadow Bands', DNA and Cell Biology, vol. 11, pp. 637 - 640, http://dx.doi.org/10.1089/dna.1992.11.637
    Journal articles | 1990
    Associate Professor Vincent Murray
    Martin RF; Murray V; D'Cunha G; Pardee M; Kampouris E; Haigh A; Kelly DP; Hodgson GS, 1990, 'Radiation sensitization by an iodine-labelled DNA ligand.', Int J Radiat Biol, vol. 57, pp. 939 - 946, http://dx.doi.org/10.1080/09553009014551061
    Journal articles | 1990
    Associate Professor Vincent Murray
    Murray V, 1990, 'Are transposons a cause of ageing?', Mutation Research DNAging, vol. 237, pp. 59 - 63, http://dx.doi.org/10.1016/0921-8734(90)90011-F
    Journal articles | 1989
    Associate Professor Vincent Murray
    Murray V, 1989, 'Improved double-stranded DNA sequencing using the linear polymerase chain reaction', Nucleic Acids Research, vol. 17, pp. 8889, http://dx.doi.org/10.1093/nar/17.21.8889
    Journal articles | 1989
    Associate Professor Vincent Murray
    Murray V; Martin RF, 1989, 'The degree of ultraviolet light damage to DNA containing iododeoxyuridine or bromodeoxyuridine is dependent on the DNA sequence', Nucleic Acids Research, vol. 17, pp. 2675 - 2691, http://dx.doi.org/10.1093/nar/17.7.2675
    Journal articles | 1988
    Associate Professor Vincent Murray
    Murray V; Martin RF, 1988, 'Sequence specificity of 125I-labelled Hoechst 33258 damage in six closely related DNA sequences.', J Mol Biol, vol. 203, pp. 63 - 73, http://dx.doi.org/10.1016/0022-2836(88)90091-5
    Journal articles | 1988
    Associate Professor Vincent Murray
    Murray V; Tan L; Matthews J; Martin RF, 1988, 'The sequence specificity of bleomycin damage in three cloned DNA sequences that differ by a small number of base substitutions', Journal of Biological Chemistry, vol. 263, pp. 12854 - 12859
    Journal articles | 1988
    Associate Professor Vincent Murray
    Murray V; Martin RF, 1988, 'Sequence specificity of 125I-labelled Hoechst 33258 in intact human cells.', J Mol Biol, vol. 201, pp. 437 - 442, http://dx.doi.org/10.1016/0022-2836(88)90150-7
    Journal articles | 1987
    Associate Professor Vincent Murray
    Murray V, 1987, 'Transversion-specific purine analogue mutagens and the mechanism of hydroxylaminopurine mutagenesis', Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, vol. 177, pp. 189 - 199, http://dx.doi.org/10.1016/0027-5107(87)90002-9
    Journal articles | 1987
    Associate Professor Vincent Murray
    Murray V, 1987, '5-Amino-4-imidazolecarboxamide is a mutagen in E. coli', Mutation Research Letters, vol. 190, pp. 89 - 94, http://dx.doi.org/10.1016/0165-7992(87)90037-6
    Journal articles | 1987
    Associate Professor Vincent Murray
    Murray V, 1987, 'O6-Methylguanine specifically induces AT→GC transition mutations', Mutation Research Letters, vol. 190, pp. 267 - 270, http://dx.doi.org/10.1016/0165-7992(87)90007-8
    Journal articles | 1987
    Associate Professor Vincent Murray
    Murray V; Martin RF, 1987, 'Nucleotide sequences of human α-DNA repeats', Gene, vol. 57, pp. 255 - 259, http://dx.doi.org/10.1016/0378-1119(87)90129-6
    Journal articles | 1985
    Associate Professor Vincent Murray
    Murray V; Martin RF, 1985, 'The sequence specificity of bleomycin-induced DNA damage in intact cells', Journal of Biological Chemistry, vol. 260, pp. 10389 - 10391
    Journal articles | 1985
    Associate Professor Vincent Murray
    Murray V; Martin RF, 1985, 'A novel method for the purification of DNA single strands suitable for DNA sequencing', Gene Analysis Techniques, vol. 2, pp. 95 - 99, http://dx.doi.org/10.1016/0735-0651(85)90004-4
    Journal articles | 1981
    Associate Professor Vincent Murray
    Murray V; Holliday R, 1981, 'Increased error frequency of DNA polymerases from senescent human fibroblasts', Journal of Molecular Biology, vol. 146, pp. 55 - 76, http://dx.doi.org/10.1016/0022-2836(81)90366-1
    Journal articles | 1981
    Associate Professor Vincent Murray
    Murray V, 1981, 'Properties of DNA polymerases from young and ageing human fibroblasts', Mechanisms of Ageing and Development, vol. 16, pp. 327 - 343, http://dx.doi.org/10.1016/0047-6374(81)90017-8
    Journal articles | 1979
    Associate Professor Vincent Murray
    Murray V; Holliday R, 1979, 'Mechanism for RNA splicing of gene transcripts', FEBS Letters, vol. 106, pp. 5 - 7, http://dx.doi.org/10.1016/0014-5793(79)80682-1
    Journal articles | 1979
    Associate Professor Vincent Murray
    Holliday R; Pukkila PJ; Dickson JM; Spanos A; Murray V, 1979, 'Relationships between the correction of mismatched bases in DNA and mutability', Cold Spring Harbor Symposia on Quantitative Biology, vol. 43, pp. 1317 - 1323, http://dx.doi.org/10.1101/sqb.1979.043.01.151
    Journal articles | 1979
    Associate Professor Vincent Murray
    Murray V; Holliday R, 1979, 'A mechanism for RNA–RNA splicing and a model for the control of gene expression', Genetical Research, vol. 34, pp. 173 - 188, http://dx.doi.org/10.1017/S0016672300019406
  • Conference Papers | 2009
    Associate Professor Vincent Murray
    Murray V; Galea AM, 2009, 'The Unique Gene Expression Profile of the Anti-tumour Agent, Cisplatin, Compared with its Clinically Ineffective Isomer, Transplatin.', in Proceedings of the 2nd International Conference on Biomedical and Pharmaceutical Engineering, IEEE, Singapore, presented at 2nd International Conference on Biomedical and Pharmaceutical Engineering, Singapore, 02 December 2009 - 04 December 2009, http://dx.doi.org/10.1109/ICBPE.2009.5384103
    Conference Papers | 2002
    Associate Professor Vincent Murray
    Galea AM; Murray VM, 2002, 'Investigating the effect of cisplatin on human gene expression using cDNA microarrays', in Takayama K (ed.), School of Biotechnology and Biomolecular Sciences 1st Annual Symposium, School of Biotechnology and Biomolecular Sciences 1st Annual Symposium, Sydney, presented at School of Biotechnology and Biomolecular Sciences 1st Annual Symposium, Sydney, 08 November 2002
    Conference Proceedings (Editor of) | 2002
    Associate Professor Vincent Murray
    Temple MD; Murray VM, (ed.), 2002, 'Genome Conference 2001: 22nd Annual Conference on the Organisation and Expression of the Genome', Lorne, Victoria, presented at Genome Conference 2001: 22nd Annual Conference on the Organisation and Expression of the Genome, Lorne, Victoria, 17 February 2002 - 21 February 2002
    Conference Proceedings (Editor of) | 2002
    Associate Professor Vincent Murray
    Murray VM; Kim A, (ed.), 2002, 'Genome Conference 2001: 22nd Annual Conference on the Organisation and Expression of the Genome', Lorne, Victoria, presented at Genome Conference 2001: 22nd Annual Conference on the Organisation and Expression of the Genome, Lorne, Victoria, 17 February 2002 - 21 February 2002
    Conference Papers | 2002
    Associate Professor Vincent Murray
    Galea AM; Murray VM, 2002, 'The Interaction of cisplatin with DNA in reconstituted chromatin', in Genome Conference 2001: 22nd Annual Conference on the Organisation and Expression of the Genome, Genome Conference 2001: 22nd Annual Conference on the Organisation and Expression of the Genome, Lorne, Victoria, pp. 44 - 44, presented at Genome Conference 2001: 22nd Annual Conference on the Organisation and Expression of the Genome, Lorne, Victoria, 17 February 2002 - 21 February 2002
    Conference Papers | 2002
    Associate Professor Vincent Murray
    Davies NP; Hardman LC; Murray VM, 2002, 'The influence of chromatin structure on cisplatin damage in intact human cells at the epsilon-globin gene promoter', in Genome Conference 2001: 22nd Annual Conference on the Organisation and Expression of the Genome, Genome Conference 2001: 22nd Annual Conference on the Organisation and Expression of the Genome, Lorne, Victoria, pp. 33 - 33, presented at Genome Conference 2001: 22nd Annual Conference on the Organisation and Expression of the Genome, Lorne, Victoria, 17 February 2002 - 21 February 2002
    Conference Papers | 2002
    Associate Professor Vincent Murray
    Kim A; Davies NP; Murray VM, 2002, 'What is present at the boundary of a DNASE I hypersensitive site? Chromatin structure at the human beta globin locus control region hypersensitive site-2', in Genome Conference 2001: 22nd Annual Conference on the Organisation and Expression of the Genome, Genome Conference 2001: 22nd Annual Conference on the Organisation and Expression of the Genome, Lorne, Victoria, pp. 11 - 11, presented at Genome Conference 2001: 22nd Annual Conference on the Organisation and Expression of the Genome, Lorne, Victoria, 17 February 2002 - 21 February 2002
    Conference Papers | 2002
    Associate Professor Vincent Murray
    Campbell HM; Katrib M; Murray VM; Gero AM, 2002, 'Potential of DNA damaging agents for antimalarial chemotherapy', in 51st ASTMH Meeting, 51st ASTMH Meeting, Denver, Colorado, presented at 51st ASTMH Meeting, Denver, Colorado
    Conference Papers | 2002
    Associate Professor Vincent Murray
    Galea AM; Murray VM, 2002, 'The interaction of anti-tumour agents with nucleosomal core DNA in reconstituted chromatin', in ComBio Conference, ComBio Conference, Sydney, presented at ComBio Conference, Sydney
    Conference Papers | 2002
    Associate Professor Vincent Murray
    Galea AM; Murray VM, 2002, 'Gene expression profiling of human tumour cells using cDNA microarrays: a model test system for anti-tumour drug development', in 2nd Australian Microarray Meeting, 2nd Australian Microarray Meeting, Sth Stradbroke Island, Australia, presented at 2nd Australian Microarray Meeting, Sth Stradbroke Island, Australia
    Conference Papers | 2002
    Associate Professor Vincent Murray
    Davies NP; Hardman LC; Murray VM, 2002, 'The influence of chromatin structure on cisplatin damage in intact human cells at the epsilon globin gene promoter', in ComBio Conference, ComBio Conference, Sydney, presented at ComBio Conference, Sydney
    Conference Papers | 2001
    Associate Professor Vincent Murray
    Temple MD; Murray VM, 2001, 'Footprinting of chromatin structure in the human beta globin gene cluster', in ComBio 2001, ComBio 2001, Canberra, pp. 43 - 43, presented at ComBio 2001, Canberra, 01 October 2001 - 04 October 2001
    Conference Papers | 1999
    Associate Professor Vincent Murray
    Kim A; Murray VM, 1999, 'Chromatin structure in locus control region hypersensitive site-2 of human beta -globin gene cluster', in World Congress of Korean Scientists and Engineers 1999, World Congress of Korean Scientists and Engineers 1999, Seoul, South Korea, presented at World Congress of Korean Scientists and Engineers 1999, Seoul, South Korea, 06 July 1999 - 16 July 1999
    Conference Proceedings (Editor of) | 1997
    Associate Professor Vincent Murray
    Murray VM; Temple MD; Cairns MJ, (eds.), 1997, 'European Molecular Biology Organisation Workshop on "Chromatin and Epigenetic Regulation', Heidelberg, Germany, presented at European Molecular Biology Organisation Workshop on "Chromatin and Epigenetic Regulation, Heidelberg, Germany, 04 October 1997 - 09 October 1997
    Conference Proceedings (Editor of) | 1997
    Associate Professor Vincent Murray
    Hardman LC; Temple MD; Murray VM, (eds.), 1997, 'Genome Conference 1997', Lorne, Victoria, presented at Genome Conference 1997, Lorne, Victoria, 17 February 1997 - 21 February 1997
    Conference Proceedings (Editor of) | 1997
    Associate Professor Vincent Murray
    Murray VM; Temple MD; Cairns MJ, (eds.), 1997, 'Genome Conference 1997', Lorne, Victoria, presented at Genome Conference 1997, Lorne, Victoria, 17 February 1997 - 21 February 1997

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