W. Alexander Donald is an Associate Professor in the School of Chemistry at UNSW Sydney who is developing and applying analytical and mass spectrometry methodologies with an emphasis on problems in chemistry and biochemistry.
Graduate of University of California, Berkeley (Ph.D., 2010). Postdoctoral Fellow & Centenary Research Fellow, University of Melbourne (2010-2012). Lecturer, UNSW Sydney (2013). Senior Lecturer, UNSW Sydney (2016). Associate Professor, UNSW Sydney (2020). ARC Future Fellowship (2020). Scientia Associate Professor (2021).
International Union of Pure and Applied Chemists Prize for Young Chemists (2011). New South Wales Fresh Science Finalist (2013). ARC Discovery Early Career Researcher Award (2013). Australian and New Zealand Society for Mass Spectrometry Michael Guilhaus Research Award (2015). RACI Physical Chemistry Division Lectureship (2016). RACI Analytical and Environmental Chemistry Division Peter W. Alexander Medal (2016). Emerging Investigator, Analytical Methods (2015), The Analyst (2016), and The Journal of the American Society for Mass Spectrometry (2017). Australian and New Zealand Society for Mass Spectrometry Bowie Medal (2019). The Analytical Scientist 2020 Power List (2020). ARC Future Fellowship (2020).
Vice President, Australian and New Zealand Society for Mass Spectrometry (2020-current). Past Chair, RACI NSW Analytical and Environmental Chemistry Group (2020-current). Treasurer, Australian and New Zealand Society for Mass Spectrometry (2016-2020). Chair, RACI NSW Analytical and Environmental Chemistry Group (2017-2020). Member, ANZSMS and RACI.
WA Donald, Cracking post-translational modification codes in high molecular definition; ARC Future Fellowship; 2020-2023
AJ Trevitt, WA Donald, C Jouvet; New laser and mass spectrometry methods for detecting protonation isomers; ARC Discovery Projects; 2020-2022
WA Donald, CT Supuran; Ultrasensitive chemical analysis of single cells by mass spectrometry; ARC Discovery Project; 2019-2021
WA Donald, CT Supuran; Rapid, Ultra-sensitive Protein Structure Elucidation by Mass Spectrometry; ARC Discovery Project; 2016-2018
Mass spectrometry is a core enabling technology that is used in many emerging and existing scientific fields. We are developing and applying experimental methods in mass spectrometry with an emphasis on fundamental and applied problems in chemistry and biochemistry.
Our current objectives are to:
Our research is highly interdisciplinary and we actively collaborate with other researchers in pharmacology & medicinal chemistry, protein engineering, bioinorganic chemistry, molecular biology, surface & materials chemistry, and electrical engineering.
1. Nguyen, G. T. H.; Tran, T. N.; Podgorski, M. N.; Bell, S. G.; Supuran, C. T.; Donald, W. A. Nanoscale ion emitters in native mass spectrometry for measuring ligand-protein binding affinities. ACS Central Science, 2019, 5, 308-318.
2. Winter, D. L.; Wilkins, M. R.; Donald, W. A. Differential ion mobility-mass spectrometry for detailed analysis of the proteome. Trends in Biotechnology, 2019, 37, 198-213.
3. Zenaidee, M. A.; Leeming, M. G.; Zhang, F.; Funston, T. T.; Donald, W. A. Highly charged protein ions: The strongest organic acids to date. Angewandte Chemie International Edition, 2017, 56, 8522-26 ("Very Important Paper").
4. Kabir, K. M. M.; Donald, W. A. Microscale differential ion mobility spectrometry for field deployable chemical analysis. Trends in Analytical Chemistry, 2017, 97, 399-427.
5. Dumlao, M. C.; Xiao, D.; Zhang, D.; Fletcher, J.; Donald, W. A. Effects of different waveforms on the performance of active capillary dielectric barrier discharge ionization mass spectrometry. Journal of the American Society for Mass Spectrometry, 2017, 28, 575-78 (Cover of Emerging Investigator Issue).
6. Leeming, M. G.; Donald, W. A.; O'Hair, R. A. J. Non-targeted identification of reactive metabolite protein adducts. Analytical Chemistry, 2017, 89, 5748-56.
7. Dumlao, M. C.; Jeffress, L. E.; Gooding, J. J.; Donald, W. A. Solid-phase microextraction low temperature plasma mass spectrometry for the direct and rapid analysis of chemical warfare simulants in complex mixtures. Analyst, 2016, 141, 3714-21 (Emerging Investigator Issue).
8. Leeming, M. G.; Isaac, A. P.; Pope, B. J.; Cranswick, N.; Wright, C. E.; Ziogas, J.; O'Hair, R. A. J.; Donald, W. A. High-Resolution Twin-Ion Metabolite Extraction (HiTIME) Mass Spectrometry: Nontargeted Detection of Unknown Drug Metabolites by Isotope Labeling, Liquid Chromatography Mass Spectrometry, and Automated High-Performance Computing. Analytical Chemistry, 2015, 87, 4104-09.
9. Zenaidee, M. A.; Donald, W. A. Electron capture dissociation of extremely supercharged protein ions formed by electrospray ionisation. Analytical Methods, 2015, 7, 7132 (Emerging Investigator Issue).
10. Teo, C. A.; Donald, W. A. Solution Additives for Supercharging Proteins Beyond the Theoretical Maximum Proton-Transfer Limit in Electrospray Ionization Mass Spectrometry. Analytical Chemistry, 2014, 86, 4455-62.
Book editor, Advances in ion-mobility mass spectrometry: Fundamentals, instrumentation, and applications (Comprehensive Analytical Chemistry, Vol. 83; Elsevier, 2019)
Associate Editor (Handling Editor), Journal of Enzyme Inhibition and Medicinal Chemistry (2019-current)
Editorial Board, International Journal of Molecular Sciences (2018-current)
Editorial Board, Expert Opinion on Therapeutic Patents (2017-current)
Editorial Board, Journal of Enzyme Inhibition and Medicinal Chemistry (2017-current)
Vice president, Australian & New Zealand Society for Mass Spectrometry (2020-current)
Past chair, Royal Australian Chemical Institute NSW Analytical and Environmental Chemistry Group (2020-current)
Treasurer, Australian & New Zealand Society for Mass Spectrometry (2016-2020)
Chair, Royal Australian Chemical Institute NSW Analytical and Environmental Chemistry Group (2017-2020)
Chair-elect, Royal Australian Chemical Institute NSW Analytical and Environmental Chemistry Group (2015-17)
Management committee, NSW Smart Sensing Network (2016-17)
Course Coordinator and Lecturer, Analytical Chemistry: Essential Methods (Second Year Level, Terms 1 and 3)
Lecturer, Chemistry 1A (First Year Level, Term 3)