Associate Professor Wallace   Bridge
Honorary Associate Professor

Associate Professor Wallace Bridge

Faculty of Science
Biotech & Biomolecular Science

Research

I have 33 years academic and industrial experience in bioprocessing-based R&D in Australia and overseas (Italy and UK). My major research areas have included: ethanol; cephalosporin C, nisin, thiol antioxidants; isoprenoids; glycosidic enzymes; lactic acid bacteria (dairy starter cultures and probiotics), bakers yeast; yeast extract manufacture; and microbial biotransformations and biocatalysis. I also dabbled in immunology in recent years, which led to a UNSW filed PCT patent application for a protein(HLA)-based tissue typing invention. My current ongoing research activities are in the fields of biocatalysis and bacteriophage-mediated biocontrol.

Biocatalysis

A patent-protected biocatalytic-based process for the manufacture of gamma-linked peptides developed by my research group is in the final stages of commercialisation. A factory for the manufacture of gamma glutamylcysteine has recently been built in Houston, Texas, and is currently being commissioned. By late 2018, it is planned to commence the marketing and retail sale of GGC-based products in the US. The GGC dipeptide is the immediate precursor to the tripeptide glutathione, which is commonly referred to as the master antioxidant as it is produced and used by almost all aerobic cells from bacteria through to humans. Many diseases and disorders - and even ageing itself - are associated with oxidative stress caused by lowered cellular glutathione levels (homeostasis). The exposure to high levels of free radicals, in particular reactive oxygen species (ROS), oxidises lipids, proteins and nucleic acids. This damages cell physiology and leads to loss of cell function and ultimately cell death (apoptosis). As GGC can systemically elevate cellular glutathione content (as confirmed in a UNSW-sponsored human clinical trial), it has a broad range of potential applications as an active ingredient in dietary supplements, cosmetics and functional foods, and possibly as a therapeutic for a large range of clinical disorders and diseases. My group's ongoing research at UNSW continues to work towards advancing the GGC manufacturing process, and to use various in vitro and in vivo models to investigate and define the therapeutic potential of GGC.

Bacteriophage-mediated biocontrol

Bacteria contamination is a significant, difficult-to-control problem in many industrial fermentation processes and in the manufacture of processed foods. To address this, my research group is partnering with industry and other research groups to develop the use of bacteriophage as biocontrol agents to limit contamination levels. 

Education

I have a long-held passion for ensuring that UNSW science students are educated in business so that they can enhance their career preparedness and flexibility, and their future value to employers and society in general.  Since 1999, I have been involved in the establishment of business and professional skill-based undergraduate and postgraduate courses and programs specifically designed for the science student. Currently, I am the Director of the undergraduate Biotechnology program (3053), a degree that covers fundamental science and the technologies it enables, and the translational processes involved in taking a science-based idea through to a marketable product. Over the years, I have collaborated with numerous international tertiary institutes to develop and teach science innovation courses and programs. 

Qualifications

  • BSc (Microbiology and Genetics). University of Sydney. 1984
  • MAppSc (Biotechnology). UNSW. 1989
  • PhD (Bioprocess Engineering). UNSW. 1993

Awards and Achievements

  • 2017: BABS Titans of Teaching award - Best student-rated Semester 1 Lecturer
  • 2017: BABS Titans of Teaching award - Best student-rated Semester 1 small course (BABS3071)
  • 2015: BABS Titans of Teaching award - Best student-rated Semester 1 small course (BABS3071)
  • 2013: BABS Outstanding Contributor Award
  • 2008: Australian Learning and Teaching Council Citation
  • 2007 UNSW Australian School of Business Faculty Entrepreneur Award
Phone
9385 1297
Location
Room: s108, Samuels

Publications

  • Books | 2008
    Associate Professor Wallace Bridge
    Hine D; Barnard R; Rifkin WD; Bridge WJ; Franco C; Schmidt LC; MacKinnon P, 2008, Extending teaching and learning initiatives in the cross-disciplinary field of Biotechnology: Carrick Discipline-Based Initiatives Scheme 2007, Original, The Carrick Institute for Learning and Teaching in Higher Education, Brisbane, Australia
  • Journal articles | 2021
    Associate Professor Wallace Bridge
    Liu Y; Chen Z; Li B; Yao H; Zarka M; Welch J; Sachdev P; Bridge W; Braidy N, 2021, 'Supplementation with γ-glutamylcysteine (γ-GC) lessens oxidative stress, brain inflammation and amyloid pathology and improves spatial memory in a murine model of AD', Neurochemistry International, vol. 144, pp. 104931, http://dx.doi.org/10.1016/j.neuint.2020.104931
    Journal articles | 2021
    Associate Professor Wallace Bridge
    Ang DL; Hoque MZ; Hossain MA; Guerriero G; Berni R; Hausman JF; Bokhari SA; Bridge WJ; Siddiqui KS, 2021, 'Computational Analysis of Thermal Adaptation in Extremophilic Chitinases: The Achilles' Heel in Protein Structure and Industrial Utilization', Molecules (Basel, Switzerland), vol. 26, http://dx.doi.org/10.3390/molecules26030707
    Journal articles | 2020
    Associate Professor Wallace Bridge
    Damnjanovic D; Vázquez-Campos X; Winter DL; Harvey M; Bridge WJ, 2020, 'Bacteriophage genotyping using BOXA repetitive-PCR', BMC Microbiology, vol. 20, pp. 154, http://dx.doi.org/10.1186/s12866-020-01770-2
    Journal articles | 2020
    Associate Professor Wallace Bridge
    Pressman P; Bridge WJ; Zarka MH; Hayes AW; Clemens R, 2020, 'Dietary γ-Glutamylcysteine: Its Impact on Glutathione Status and Potential Health Outcomes.', J Diet Suppl, pp. 1 - 11, http://dx.doi.org/10.1080/19390211.2020.1856266
    Journal articles | 2020
    Associate Professor Wallace Bridge
    Capraro A; Whan R; Thomas S; Jaffe A; Bridge W; Waters S, 2020, 'Novel Antioxidant Therapy with the Immediate Precursor to Glutathione, -Glutamylcysteine (GGC), Ameliorates LPS-Induced Cellular Stress in In Vitro 3D-Differentiated Airway Model from Primary Cystic Fibrosis Human Bronchial Cells', Antioxidants, http://dx.doi.org/10.3390/antiox9121204
    Journal articles | 2020
    Associate Professor Wallace Bridge
    Hewson C; Capraro A; Wong S; Pandzic E; Fernando BSM; Awatade N; Zhong L; Hart-Smith G; Whan R; Thomas S; Jaffe A; Bridge W; Waters S, 2020, 'Novel antioxidant therapy with the immediate precursor to glutathione, γ-glutamylcysteine (GGC), ameliorates LPS-induced cellular stress in an in vitro cystic fibrosis model', , http://dx.doi.org/10.1101/2020.05.27.119990
    Journal articles | 2019
    Associate Professor Wallace Bridge
    Damnjanovic D; Harvey M; Bridge WJ, 2019, 'Application of colony BOXA2R-PCR for the differentiation and identification of lactic acid COCCI', Food Microbiology, vol. 82, pp. 277 - 286, http://dx.doi.org/10.1016/j.fm.2019.02.011
    Journal articles | 2019
    Associate Professor Wallace Bridge
    Ferguson GD; Bridge WJ, 2019, 'The glutathione system and the related thiol network in Caenorhabditis elegans.', Redox Biol, vol. 24, pp. 101171, http://dx.doi.org/10.1016/j.redox.2019.101171
    Journal articles | 2019
    Associate Professor Wallace Bridge
    Braidy N; Zarka M; Jugder B-E; Welch J; Jayasena T; Chan DKY; Sachdev P; Bridge W, 2019, 'The Precursor to Glutathione (GSH), γ-Glutamylcysteine (GGC), Can Ameliorate Oxidative Damage and Neuroinflammation Induced by Aβ40 Oligomers in Human Astrocytes', Frontiers in Aging Neuroscience, vol. 11, pp. 1 - 1, http://dx.doi.org/10.3389/fnagi.2019.00177
    Journal articles | 2017
    Associate Professor Wallace Bridge
    Zarka MH; Bridge WJ, 2017, 'Oral administration of γ-glutamylcysteine increases intracellular glutathione levels above homeostasis in a randomised human trial pilot study', Redox Biology, vol. 11, pp. 631 - 636, http://dx.doi.org/10.1016/j.redox.2017.01.014
    Journal articles | 2017
    Associate Professor Wallace Bridge
    Bridge W, 2017, 'The Struggle to Establish Bioentrepreneurship Education Programs: An Australian Perspective', Technology Transfer and Entrepreneurship, vol. 4, http://dx.doi.org/10.2174/2213809904666170809145045
    Journal articles | 2016
    Associate Professor Wallace Bridge
    Ferguson G; Bridge W, 2016, 'Glutamate cysteine ligase and the age-related decline in cellular glutathione: The therapeutic potential of γ-glutamylcysteine.', Arch Biochem Biophys, vol. 593, pp. 12 - 23, http://dx.doi.org/10.1016/j.abb.2016.01.017
    Journal articles | 2016
    Associate Professor Wallace Bridge
    Cao P; Braidy N; Zarka M; Welch J; Bridge W, 2016, 'Therapeutic Approaches to Modulating Glutathione Levels as a Pharmacological Strategy in Alzheimer's Disease (vol 12, pg 298, 2015)', CURRENT ALZHEIMER RESEARCH, vol. 13, pp. 1198 - 1198, http://dx.doi.org/10.2174/156720501310160825221218
    Journal articles | 2015
    Associate Professor Wallace Bridge
    Braidy N; Zarka M; Welch J; Bridge W, 2015, 'Therapeutic approaches to modulating glutathione levels as a pharmacological strategy in Alzheimer’s disease', Current Alzheimer Research, vol. 12, pp. 298 - 313, http://dx.doi.org/10.2174/1567205012666150302160308
    Journal articles | 2014
    Associate Professor Wallace Bridge
    Braidy N; Essa MM; Bridge WB; Subash SS; Manivasagam TM; Vijayan RKV; Al-Adawi SA; Guillemin GG, 2014, 'REVIEW OF NATURAL PRODUCTS ON PARKINSON’S DISEASE PATHOLOGY', Journal of Aging Research & Clinical Practice, vol. 3, pp. 127 - 136
    Journal articles | 2012
    Associate Professor Wallace Bridge
    Bridge WJ; Chandler SD; Zarka M; Vinaya Babu SN; Suhas Y; Raghunatha Reddy K, 2012, 'Safety assessment of gamma-glutamylcysteine sodium salt', Regulatory Toxicology and Pharmacology, vol. 64, pp. 17 - 25, http://dx.doi.org/10.1016/j.yrtph.2012.05.008
    Journal articles | 2008
    Associate Professor Wallace Bridge
    Hine D; Barnard R; Rifkin W; Bridge W; Franco C; Schmidt L; MacKinnon P, 2008, 'University biotechnology education in Australia in an international context', JOURNAL OF BIOTECHNOLOGY, vol. 136, pp. S770 - S770, http://dx.doi.org/10.1016/j.jbiotec.2008.07.1665
    Journal articles | 2007
    Associate Professor Wallace Bridge
    Boonmee M; Leksawasdi N; Bridge WJ; Rogers PL, 2007, 'Electrodialysis for lactate removal in the production of the dairy starter culture Lactococcus lactis NZ133', International Journal of Food Science and Technology, vol. 42, pp. 567 - 572, http://dx.doi.org/10.1111/j.1365-2621.2006.01276.x
    Journal articles | 2003
    Associate Professor Wallace Bridge
    Boonmee M; Leksawasdi N; Bridge WJ; Rogers PL, 2003, 'Batch and continuous culture of Lactococcus lactis NZ133: experimental data and model development', Biochemical Engineering Journal, vol. 14, pp. 127 - 135, http://dx.doi.org/10.1016/S1369-703X(02)00171-7
  • Conference Abstracts | 2020
    Associate Professor Wallace Bridge
    Hewson C; Wong S; Awatade N; Bridge W; Jaffe A; Waters S, 2020, 'A NOVEL COMPOUND FOR CYSTIC FIBROSIS THERAPY, TARGETING THE PROTEOSTASIS NETWORK', in Respirology, Wiley, Melbourne, Australia_Cancelled due to COVID-19, presented at TSANZ20_The Thoracic Society of Australia and New Zealand (ANZSRS/TSANZ) Annual Scientific Meeting for Leaders in Lung Health, Melbourne, Australia_Cancelled due to COVID-19, http://dx.doi.org/10.1111/resp.13777
    Conference Abstracts | 2013
    Associate Professor Wallace Bridge
    Braidy N; Poljak A; Zarka M; Bridge W; Sachdev P, 2013, 'γ-glutamylcysteine (GGC)-mediated upregulation of glutathione levels can ameliorate toxicity of natural beta-amyloid oligomers in primary adult human neurons [Abstract P4-332]', in Alzheimer's & Dementia, Alzheimer’s Association International Conference (AAIC) 2013, Boston, MA, USA, Vol. 9, pp. P854 - P854, presented at Alzheimer’s Association International Conference (AAIC) 2013, Boston, MA, USA, 13 July 2013 - 18 July 2013, http://dx.doi.org/10.1016/j.jalz.2013.08.166

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