Dr Vicky Tsai

Back to

Dr Vicky Tsai received her PhD from the University of Queensland, followed by postdoctoral training at Academia Sinica in Taiwan, where she led a study identifying a key neuroinflammatory mechanism driving amyloid plaque accumulation. She later joined Prof. Sam Breit’s team in the Inflammation and Cytokine Biology Program at St Vincent’s Centre for Applied Medical Research, where her research focus shifted to neuronal circuitry underlying appetite regulation and metabolism.

Dr Tsai played a central role in the NHMRC-recognised studies on GDF15/MIC-1 (Project Grant 1057910; NHMRC Ten of the Best Projects 2011), where she defined its signalling pathways and demonstrated its central role in cachexia, appetite control, and metabolic regulation. Her work has significantly contributed to the development of therapeutic strategies targeting GDF15 inhibition for the treatment of cachexia, now validated in Phase II clinical trials.

Phone

02 8382 4920

E-mail

vicky.tsai@svha.org.au

Location

St Vincen'ts Centre for Applied Medical Research (AMR) Level 8, Lowy Packer Building 405 Liverpool Street, Darlinghurst NSW 2010

Journal articles | 2025

Breit SN; Tsai VW, 2025, 'Metabolic Messenger: growth differentiation factor 15', Nature Metabolism, 7, pp. 1732 - 1744, http://dx.doi.org/10.1038/s42255-025-01353-3

Journal articles | 2024

Breit SN; Brown DA; Tsai VWW, 2024, 'GDF15 research from bench to bedside', Cancer Cell, 42, pp. 1823 - 1824, http://dx.doi.org/10.1016/j.ccell.2024.10.002

Journal articles | 2024

Isik FI; Thomson S; Cueto JF; Spathos J; Breit SN; Tsai VWW; Brown DA; Finney CA, 2024, 'A systematic review of the neuroprotective role and biomarker potential of GDF15 in neurodegeneration', Frontiers in Immunology, 15, http://dx.doi.org/10.3389/fimmu.2024.1514518

Journal articles | 2023

Breit SN; Brown DA; Tsai VWW, 2023, 'GDF15 analogs as obesity therapeutics', Cell Metabolism, 35, pp. 227 - 228, http://dx.doi.org/10.1016/j.cmet.2023.01.002

Journal articles | 2023

Breit SN; Manandhar R; Zhang HP; Lee-Ng M; Brown DA; Tsai VWW, 2023, 'GDF15 enhances body weight and adiposity reduction in obese mice by leveraging the leptin pathway', Cell Metabolism, 35, pp. 1341 - 1355.e3, http://dx.doi.org/10.1016/j.cmet.2023.06.009

Journal articles | 2023

Thai LM; O'Reilly L; Reibe-Pal S; Sue N; Holliday H; Small L; Schmitz-Peiffer C; Dhenni R; Wang-Wei Tsai V; Norris N; Yau B; Zhang X; Lee K; Yan C; Shi YC; Kebede MA; Brink R; Cooney GJ; Irvine KM; Breit SN; Phan TG; Swarbrick A; Biden TJ, 2023, 'β-cell function is regulated by metabolic and epigenetic programming of islet-associated macrophages, involving Axl, Mertk, and TGFβ receptor signaling', Iscience, 26, http://dx.doi.org/10.1016/j.isci.2023.106477

Journal articles | 2021

Breit SN; Brown DA; Tsai VWW, 2021, 'The GDF15-GFRAL Pathway in Health and Metabolic Disease: Friend or Foe?', Annual Review of Physiology, 83, pp. 127 - 151, http://dx.doi.org/10.1146/annurev-physiol-022020-045449

Journal articles | 2020

Husaini Y; Tsai VWW; Manandhar R; Zhang HP; Lee-Ng KKM; Lebhar H; Marquis CP; Brown DA; Breit SN, 2020, 'Growth differentiation factor-15 slows the growth of murine prostate cancer by stimulating tumor immunity', Plos One, 15, http://dx.doi.org/10.1371/journal.pone.0233846

Journal articles | 2019

Tsai VWW; Zhang HP; Manandhar R; Schofield P; Christ D; Lee-Ng KKM; Lebhar H; Marquis CP; Husaini Y; Brown DA; Breit SN, 2019, 'GDF15 mediates adiposity resistance through actions on GFRAL neurons in the hindbrain AP/NTS', International Journal of Obesity, 43, pp. 2370 - 2380, http://dx.doi.org/10.1038/s41366-019-0365-5

Journal articles | 2018

Tsai VW; Zhang HP; Manandhar R; Lee-Ng KKM; Lebhar H; Marquis CP; Husaini Y; Sainsbury A; Brown DA; Breit SN, 2018, 'Treatment with the TGF-b superfamily cytokine MIC-1/GDF15 reduces the adiposity and corrects the metabolic dysfunction of mice with diet-induced obesity', International Journal of Obesity, 42, pp. 561 - 571, http://dx.doi.org/10.1038/ijo.2017.258

Journal articles | 2018

Tsai VWW; Brown DA; Breit SN, 2018, 'Targeting the divergent TGFb superfamily cytokine MIC-1/GDF15 for therapy of anorexia/ cachexia syndromes', Current Opinion in Supportive and Palliative Care, 12, pp. 404 - 409, http://dx.doi.org/10.1097/SPC.0000000000000384

Journal articles | 2018

Tsai VWW; Husaini Y; Sainsbury A; Brown DA; Breit SN, 2018, 'The MIC-1/GDF15-GFRAL Pathway in Energy Homeostasis: Implications for Obesity, Cachexia, and Other Associated Diseases', Cell Metabolism, 28, pp. 353 - 368, http://dx.doi.org/10.1016/j.cmet.2018.07.018

Journal articles | 2017

Breit SN; Tsai VWW; Brown DA, 2017, 'Targeting Obesity and Cachexia: Identification of the GFRAL Receptor–MIC-1/GDF15 Pathway', Trends in Molecular Medicine, 23, pp. 1065 - 1067, http://dx.doi.org/10.1016/j.molmed.2017.10.005

Journal articles | 2017

Danta M; Barber DA; Zhang HP; Lee-Ng M; Baumgart SWL; Tsai VWW; Husaini Y; Saxena M; Marquis CP; Errington W; Kerr S; Breit SN; Brown DA, 2017, 'Macrophage inhibitory cytokine-1/growth differentiation factor-15 as a predictor of colonic neoplasia', Alimentary Pharmacology and Therapeutics, 46, pp. 347 - 354, http://dx.doi.org/10.1111/apt.14156

Journal articles | 2017

Low JK; Ambikairajah A; Shang K; Brown DA; Tsai VWW; Breit SN; Karl T, 2017, 'First behavioural characterisation of a knockout mouse model for the transforming growth factor (TGF)-β superfamily cytokine, MIC-1/GDF15', Plos One, 12, pp. e0168416, http://dx.doi.org/10.1371/journal.pone.0168416

Journal articles | 2016

Salao K; Jiang L; Li H; Tsai VWW; Husaini Y; Curmi PMG; Brown LJ; Brown DA; Breit SN, 2016, 'CLIC1 regulates dendritic cell antigen processing and presentation by modulating phagosome acidification and proteolysis', Biology Open, 5, pp. 620 - 630, http://dx.doi.org/10.1242/bio.018119

Journal articles | 2016

Tsai VWW; Lin S; Brown DA; Salis A; Breit SN, 2016, 'Anorexia-cachexia and obesity treatment may be two sides of the same coin: Role of the TGF-b superfamily cytokine MIC-1/GDF15', International Journal of Obesity, 40, pp. 193 - 197, http://dx.doi.org/10.1038/ijo.2015.242

Journal articles | 2015

Baracos V; Muscaritoli M; Aversa Z; Fanelli FR; Loumaye A; de Barsy M; Nachit M; Frateur L; Lause P; Van Maanen A; Thissen J; Awasthi R; Gillis C; Liberman S; Stein B; Charlebois P; Carli F; Ahmad ; Chiche D; Kazemi-Bajestani SMR; Becher H; Venner P; North S; Vickie B; Li Y-P; Zhang G; Ma J; Hall D; Patel D; Robinson S; Di Marco S; Gallouzi I-E; Sartori R; Penna F; Costelli P; Sandri M; Gregorevic P; Toth MJ; Miller MS; Callahan DM; Couch ME; Dittus K; Sharma M; Argilés JM; Bedard N; Wiles B; Jammoul S; Miao M; Wykes L; Coyne E; Hallauer P; Hastings K; Stretch C; Baracos V; Chevalier S; Wing S; Marchildon F; Lala N; St-Louis C; Wiper-Bergeron N; Silva KAS; Dong J; Tweardy DJ; Mitch WE; Zhang L; Hall DT; F J; Griss T; Jones RG; Di Marco S; Gallouzi I-E; Marks DL; Rudnicki MA; Laine A; Narayanan S; Choy H; Girard L; Gazdar A; Minna J; Infante R; Iyengar P; Petruzzelli M; Schweiger M; Rincon M; Robertson G; Zechner R; Wagner EF; Penna F; Pin F; Costamagna D; Camperi A; Sampaolesi M; Costelli P; He W; Talbert E; Londhe P; Bloomston M; Croce C; Guttridge D; Breit SN; Tsai VW; Manandhar R; Lin S; Sainsbury A; Brown DA; Ferrara M; Reano S; Angelino E; Sabry O; Filigheddu N; Graziani A; Robertson G; Tsoli M; Allen J; Taylor R; Scwheiger M; Swarbrick MM; Ehteda A; Miekle P; Zechner R; Molloy M; Waning DL; Mohammad KS; Reiken S; Xie W; Marks AR; Guise TA; Moya R; Zhao C; Davies JD; Carson J; Couch ME; Stecher M; Mouelhi ME; Tseng Y-C; Kulp SK; Lai I-L; Hsu E-C; He WA; Frankhouser DE; Yan PS; Mo X; Bloomston M; Lesinski GB; Marcucci G; Guttridge DC; Bekaii-Saab T; Chen C-S; Al Haddad A; Al-Azwani E; Mahamoud Y; Safi F; Salhat HE; Malek J; Adrian T; Fearon K; Temel J; Currow D; Gleich L; Friend J; Abernethy A; Garcia JM; Ma J; Hall DT; Robinson S; Patel D; Di Marco S; Gallouzi I-E; Dubé A; Patoine D; Lemire B; Thériault M-E; Ribeiro F; Debigaré R; Maltais F; Smuder AJ; Min K; Kwon O-S; Wiggs MP; Sollanenk KJ; Christou DD; Yoo J-K; Hwang M-H; Szeto HH; Kavazis AN; Powers SK; Kroenke CH; Meyerhardt JA; Kwan ML; Prado C; Xiao J; Weltzien E; Castillo A; Caan BJ; Guan C; Giles K; Wing S; Mazurak V; Baracos V; Jagoe RT; Wiles B; Miao M; Coyne E; Larose L; Cybulsky AV; Wing SS; Marino FE; Risbridger G; Gold E; Marchildon F; Wiper-Bergeron N; Segatto M; Fittipaldi R; Costelli P; Caretti G; Lee H; Fu D; Lala N; Wiper-Bergeron N; Dwarkasing J; Boekschoten M; Argilès J; van Dijk M; Busquets S; Penna F; Toledo M; Laviano A; Witkamp R; van Norren K; Bédard N; Plourde M; Baracos V; Chevalier S; Wing SS; Lala-Tabbert N; Marchildon F; Fu D; Wiper-Bergeron N; Torabi S; Glare P; Plodkowski A; Margaron Y; Fernandes M; Morales D; Poydenot P; Menager P; Fuchs A; Degot S; He WA; Calore F; Londhe P; Canella A; Guttridge DC; Croce CM; Narayanan S; Laine A; Srinivasan K; Pulliparracharuvil S; Choy H; Meyer J; Gazdar A; Minna J; Scherer PE; Infante R; Iyengar P; Kambadur R; Martinelli GB; Talamini L; Previdi S; Piccirillo R; Jafri SH; Previgliano C; Khandelwal K; Shi R; Mills G; Amato R; Coats V; Ribeiro F; Tremblay L; Lacasse Y; Maltais F; Saey D; AL Vigano A; Ciutto L; Di Tomasso J; Kilgour RD; Morais JA; Borod M; Almasud A; Giles K; Baracos V; Guan L; Mazurak V; Khanuja J; Gresham G; Osipov A; Tan C-R; Tuli R; Hendifar A; Narasimhan A; Greiner R; Yasui Y; Bathe O; Fearon K; Baracos V; Damaraju S; Banh T; Kliewer K; Hsiao Y-H; Belury MA; Caan B; Kroenke CH; Prado C; Meyerhardt JA; Weltzien E; Xiao J; Quesenberry C; Kwan M; Castillo A; Prado CM; Baracos VE; Xiao J; Birdsell L; Stuyckens K; Park YC; Parekh T; Sawyer MB; Wu C; Fernandez ; Criswell T; Chidiac T; Guttridge D; Villalona-Calero M; Bekaii-Saab T; Ciutto L; Di Tomasso J; Kilgour RD; Khan S; Morais JA; Borod M; ALVigano A; Fu D; Wiper-Bergeron N; Matos-Neto E; Figuerêdo R; Camargo R; Lima J; Alves M; Riccardi D; Alcantara P; Pinhata J; Maximiano L; Seelaender M; Lamarche É; Wiper-Bergeron N; Au ED; Desai AP; Koniaris LG; Zimmers TA; Manring H; He W; Guttridge DC; Weisleder N; Okamura H; Tseng Y-C; Kulp SK; Lai I-L; He WA; Frankhouser D; Yan P; Guttridge DC; Marcucci G; Bekaii-Saab T; Chen C-S; di Tomasso J; Del Fabbro EG; Davis MP; Fearon KC; Jatoi AA; Vigano A; Giles K; Putman T; Baracos V; Mazurak V; Kezhuo Z; Sladek R; Enjiu L; Camargo R; Gomes S; Matos-Neto E; Laviano A; Rossi-Fanneli F; Seelaender M; Ebadi M; Baracos VE; Mazurak VC; Bhatia N; Padliya ND; Stadler V; Dariani M; Hariri RJ; Parker VA; Matthews RR; Bonetto A; Puppa M; Kang KS; Carson J; Guise TA; Mohammed KS; Robling AG; Koniaris LG; Zimmers TA; Toledo M; Penna F; Oliva F; Luque M; Betancourt A; Marmonti E; López-Soriano FJ; Argilés JM; Busquets S; Theal R; Jiang H; Sanchez A; Hussain SN; Wing SS; Morais JA; Chevalier S; Serpe R; Madeddu C; Gudiño V; Gabba S; Antoni G; Busquets S; Macciò A; Banni S; Koniaris LG; Zimmers TA, 2015, 'Abstracts of the 2nd Cancer Cachexia Conference, Montreal, Canada, 26–28 September 2014', Journal of Cachexia Sarcopenia and Muscle, 6, pp. 2 - 31, http://dx.doi.org/10.1002/jcsm.12004

Journal articles | 2015

Husaini Y; Lockwood GP; Nguyen TV; Tsai VWW; Mohammad MG; Russell PJ; Brown DA; Breit SN, 2015, 'Macrophage inhibitory cytokine-1 (MIC-1/GDF15) gene deletion promotes cancer growth in TRAMP prostate cancer prone mice', Plos One, 10, pp. e0115189, http://dx.doi.org/10.1371/journal.pone.0115189

Journal articles | 2015

Tsai VW-W; Macia L; Feinle-Bisset C; Manandhar R; Astrup A; Raben A; Lorenzen JK; Schmidt PT; Wiklund F; Pedersen NL; Campbell L; Kriketos A; Xu A; Zhou P; Jia W; Curmi PMG; Angstmann CN; Lee-Ng KKM; Zhang HP; Marquis CP; Husaini Y; Beglinger C; Lin S; Herzog H; Brown DA; Sainsbury A; Breit SN, 2015, 'Serum Levels of Human MIC-1/GDF15 Vary in a Diurnal Pattern, Do Not Display a Profile Suggestive of a Satiety Factor and Are Related to BMI', PLOS ONE, 10, http://dx.doi.org/10.1371/journal.pone.0133362

Journal articles | 2014

Mohammad MG; Tsai VWW; Ruitenberg MJ; Hassanpour M; Li H; Hart PH; Breit SN; Sawchenko PE; Brown DA; Hassanpour Golakani M, 2014, 'Immune cell trafficking from the brain maintains CNS immune tolerance', Journal of Clinical Investigation, 124, pp. 1228 - 1241, http://dx.doi.org/10.1172/JCI71544

Journal articles | 2014

Mohammad MG; Tsai VWW; Ruitenberg MJ; Hassanpour M; Li H; Hart PH; Breit SN; Sawchenko PE; Brown DA, 2014, 'A forebrain-immune cell pathway for the maintenance of CNS immune tolerance', Neurology, Psychiatry and Brain Research, 20, pp. 8 - 9, http://dx.doi.org/10.1016/j.npbr.2014.01.144

Journal articles | 2014

Tsai VW-W; Macia L; Manandhar R; Wiklund F; Grönberg H; Pedersen N; Lee-Ng M; Zhang HP; Brown D; Herzog H; Sainsbury A; Breit SN, 2014, 'Macrophage inhibitory cytokine 1 (MIC-1/GDF15), a novel regulator of body weight and appetite and a potential therapeutic for obesity', Obesity Research & Clinical Practice, 8, pp. 105 - 105, http://dx.doi.org/10.1016/j.orcp.2014.10.191

Journal articles | 2014

Tsai VWW; Manandhar R; Jrøgensen SB; Lee-Ng KKM; Zhang HP; Marquis CP; Jiang L; Husaini Y; Lin S; Sainsbury A; Sawchenko PE; Brown DA; Breit SN; Lee-Ng M, 2014, 'The anorectic actions of the TGFβ cytokine MIC-1/GDF15 require an intact brainstem area postrema and nucleus of the solitary tract', Plos One, 9, pp. e100370, http://dx.doi.org/10.1371/journal.pone.0100370

Journal articles | 2012

Breit SN; Carrero JJ; Tsai VW-W; Yagoutifam N; Luo W; Kuffner T; Bauskin AR; Wu L; Jiang L; Barany P; Heimburger O; Murikami M-A; Apple FS; Marquis CP; Macia L; Lin S; Sainsbury A; Herzog H; Law M; Stenvinkel P; Brown DA, 2012, 'Macrophage inhibitory cytokine-1 (MIC-1/GDF15) and mortality in end-stage renal disease', Nephrology Dialysis Transplantation, 27, pp. 70 - 75, http://dx.doi.org/10.1093/ndt/gfr575

Journal articles | 2012

Husaini Y; Qiu MR; Lockwood GP; Luo XW; Shang P; Kuffner T; Tsai VW-W; Jiang L; Russell PJ; Brown DA; Breit SN, 2012, 'Macrophage inhibitory cytokine-1 (MIC-1/GDF15) slows cancer development but increases metastases in TRAMP prostate cancer prone mice.', PLoS One, 7, pp. e43833, http://dx.doi.org/10.1371/journal.pone.0043833

Journal articles | 2012

Macia L; Tsai VW-W; Nguyen AD; Johnen H; Kuffner T; Shi Y-C; Lin S; Herzog H; Brown DA; Breit SN; Sainsbury A, 2012, 'Macrophage inhibitory cytokine 1 (MIC-1/GDF15) decreases food intake, body weight and improves glucose tolerance in mice on normal & obesogenic diets.', PLoS One, 7, pp. e34868, http://dx.doi.org/10.1371/journal.pone.0034868

Journal articles | 2012

Mohammad M; Hassanpour M; Tsai V; Li H; Ruitenberg M; Booth D; Serrats J; Hart P; Symonds G; Sawchenko P; Breit S; Brown D, 2012, 'Dendritic Cells and Multiple Sclerosis: Disease, Tolerance and Therapy', International Journal of Molecular Sciences, 14, pp. 547 - 562, http://dx.doi.org/10.3390/ijms14010547

Journal articles | 2011

Breit SN; Johnen H; Cook AD; Tsai VWW; Mohammad MG; Kuffner T; Zhang HP; Marquis CP; Jiang L; Lockwood G; Lee-Ng M; Husaini Y; Wu L; Hamilton JA; Brown DA, 2011, 'The TGF-β superfamily cytokine, MIC-1/GDF15: A pleotrophic cytokine with roles in inflammation, cancer and metabolism', Growth Factors, 29, pp. 187 - 195, http://dx.doi.org/10.3109/08977194.2011.607137

Journal articles | 2011

Brown DA; Tsai VWW; Mohammad MG; Tolhurst O; Breit SN; Sawchenko PE, 2011, 'CCAAT/enhancer binding protein-delta (C/EBPdelta) regulates Th17/Treg balance via an antigen presenting cell - interleukin-10 dependent mechanism in neuroinflammation', MULTIPLE SCLEROSIS JOURNAL, 17, pp. S344 - S344, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209137301142&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Journal articles | 2008

Kuo L-H; Hu M-K; Hsu W-M; Tung Y-T; Wang B-J; Tsai W-W; Yen C-T; Liao Y-F, 2008, 'Tumor necrosis factor-alpha-elicited stimulation of gamma-secretase is mediated by c-Jun N-terminal kinase-dependent phosphorylation of presenilin and nicastrin.', Mol Biol Cell, 19, pp. 4201 - 4212, http://dx.doi.org/10.1091/mbc.e07-09-0987

Journal articles | 2007

Johnen H; Lin S; Kuffner T; Brown DA; Tsai VW-W; Bauskin AR; Wu L; Pankhurst G; Jiang L; Junankar S; Hunter M; Fairlie WD; Lee NJ; Enriquez RF; Baldock PA; Corey E; Apple FS; Murakami MM; Lin E-J; Wang C; During MJ; Sainsbury A; Herzog H; Breit SN, 2007, 'Tumor-induced anorexia and weight loss are mediated by the TGF-beta superfamily cytokine MIC-1.', Nat Med, 13, pp. 1333 - 1340, http://dx.doi.org/10.1038/nm1677

Journal articles | 2005

Tsai VWW; Dodd PR; Lewis RJ, 2005, 'The effects of alanine-substituted conantokin-G and ifenprodil on the human spermine-activated N-methyl-D-aspartate receptor', Neuroscience, 130, pp. 457 - 464, http://dx.doi.org/10.1016/j.neuroscience.2004.09.039

Journal articles | 2005

Tsai VWW; Scott HL; Lewis RJ; Dodd PR, 2005, 'The role of group I metabotropic glutamate receptors in neuronal excitotoxicity in alzheimer's disease', Neurotoxicity Research, 7, pp. 125 - 141, http://dx.doi.org/10.1007/BF03033782

Journal articles | 2002

Andersen DL; Eckert AL; Tsai VWW; Burke CJ; Tannenberg AEG; Dodd PR, 2002, 'GABAA receptor sites in the developing human foetus', Developmental Brain Research, 139, pp. 107 - 119, http://dx.doi.org/10.1016/S0165-3806(02)00534-5
Conference Abstracts | 2016

Mohammad MG; Tsai V; Li H; Hassanpour M; Hart P; Breit S; Sawchenko P; Brown D, 2016, 'A choroid-forebrain-lymphatic pathway for the maintenance of CNS immune tolerance', in EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY-BLACKWELL, AUSTRALIA, Melbourne, Vol. 46, pp. 166 - 166, presented at International Congress of Immunology (ICI), AUSTRALIA, Melbourne, 21 August 2016 - 26 August 2016, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000383610400332&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Papers | 2014

Mohammad M; Tsai VWW; Ruitenberg M; Hassanpour M; Li H; Hart P; Breit S; Sawchenko P; Brown D, 2014, 'CNS DCs modulate peripheral anti-CNS immunity', in JOURNAL OF NEUROIMMUNOLOGY, ELSEVIER SCIENCE BV, GERMANY, Mainz, pp. 82 - 82, presented at 12th International Congress of Neuroimmunology (ISNI), GERMANY, Mainz, 09 November 2014 - 13 November 2014, http://dx.doi.org/10.1016/j.jneuroim.2014.08.218

Conference Papers | 2012

Mohammad MG; Tsai VWW; Hassanpour M; Li H; Breit SN; Hart PH; Sawchenko PE; Brown DA, 2012, 'A Forebrain Immune Cellular Pathway for the Prevention of CNS Autoimmunity', in JOURNAL OF NEUROIMMUNOLOGY, ELSEVIER SCIENCE BV, Boston, MA, pp. 124 - 124, presented at 11th International Congress of Neuroimmunology (ISNI), Boston, MA, 04 November 2012 - 08 November 2012, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000312764800334&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Papers | 2011

Breit SN; Husaini Y; Lockwood G; Kuffner T; Tsai V; Luo XW; Jiang L; Lee-Ng M; Zhang HP; Wu L; Brown DA, 2011, 'PS1-090 The role of the TGF-β superfamily cytokine MIC-1/GDF15 in biology and medicine', in Cytokine, Elsevier BV, pp. 40 - 40, http://dx.doi.org/10.1016/j.cyto.2011.07.122

Conference Papers | 2008

Breit SN; Johnen H; Lin S; Kuffner T; Brown DA; Tsai V; Bauskin AR; Corey L; Sainsbury A; Herzog H, 2008, 'The TGF-beta superfamily cytokine MIC-1 causes tumour-induced anorexia/cachexia by modulating appetite control centres in the hypothalamus', in Cytokine, Academic Press Ltd Elsevier Science Ltd, London, England, pp. 323 - 323, presented at Cytokine, -

Major Publications:

1. Breit, S. N. & Tsai, V. W. Metabolic Messenger: growth differentiation factor 15. Nat Metab (2025).

2. Breit, S. N., Brown, D. A. & Tsai, V. W. W. GDF15 research from bench to bedside. Cancer Cell S1535-6108(24)00365 (2024).

3. Breit, S. N. et al. GDF15 enhances body weight and adiposity reduction in obese mice by leveraging the leptin pathway. Cell Metab 35, 1341-1355.e3 (2023).

4. Breit, S. N., Brown, D. A. & Tsai, V. W. W. GDF15 analogs as obesity therapeutics. Cell Metab 35, 227-228 (2023).

5. Tsai, V. W. et al. GDF15 mediates adiposity resistance through actions on GFRAL neurons in the hindbrain AP/NTS. Int J Obes (Lond) 43, 2370-2380 (2019).

6. Tsai, V. W. et al. Treatment with the TGF-b superfamily cytokine MIC-1/GDF15 reduces the adiposity and corrects the metabolic dysfunction of mice with diet-induced obesity. Int J Obes (Lond) 42, 561-571 (2018).

7. Tsai, V. W. W., Husaini, Y., Sainsbury, A., Brown, D. A. & Breit, S. N. The MIC-1/GDF15-GFRAL Pathway in Energy Homeostasis: Implications for Obesity, Cachexia, and Other Associated Diseases. Cell Metab 28, 353-368 (2018).

Follow

Dr Vicky Tsai