Dr Wei-Ju Chang

Dr Wei-Ju Chang

Senior Lecturer
  • Bachelor of Science in Physical Therapy, National Taiwan University, Taiwan
  • Masters of Orthopaedics, Sports and Manual Physiotherapy, University of South Australia, Australia
  • PhD, Western Sydney Australia, Australia

 

 

Medicine & Health
School of Health Sciences

I am a Senior Lecturer in Musculoskeletal Physiotherapy at UNSW Sydney, an honorary Postdoctorate Research Fellow at Neuroscience Research Australia (NeuRA), and an Australia Physiotherapy Association Titled Musculoskeletal Physiotherapist. I have 25 years of clinical experience, specialising in managing complex musculoskeletal pain disorders and Men's health. While working as a research and teaching academic, I continue part-time clinical practice at Macarthur Physiotherapy.

I obtained Bachelor of Science in Physical Therapy (National Taiwan University) and a masters degree in Orthopaedics, Sports and Manual Physiotherapy (University of South Australia). I was awarded a prestigious NHMRC Postgraduate Scholarship to complete my PhD (Western Sydney University) investigated the role of neuroplasticity in the transition from acute to musculoskeletal pain and non-invasive brain stimulation for treating chronic pain. I continued my Postdoctoral research at Neuroscience Research Australia and clinical practice until taking up a Lecturer position in Physiotherapy at the University of Newcastle (2022 January - 2024 June). 

 

Phone
+61-2-9348 1633
  • Journal articles | 2024
    Chang WJ; Humburg P; Jenkins LC; Buscemi V; Gonalez-Alvarez ME; McAuley JH; Liston MB; Schabrun SM, 2024, 'Can assessment of human assumed central sensitisation improve the predictive accuracy of the STarT Back screening tool in acute low back pain?', Musculoskeletal Science and Practice, 74, http://dx.doi.org/10.1016/j.msksp.2024.103177
    Journal articles | 2024
    Chang WJ; Jenkins LC; Humburg P; Schabrun SM, 2024, 'The Influence of Pain Hypersensitivity and Psychological Factors on Pain and Disability in the Transition From Acute to Chronic Low Back Pain: A Longitudinal Exploratory Investigation and Cluster Analysis', Journal of Pain, 25, http://dx.doi.org/10.1016/j.jpain.2024.104584
    Journal articles | 2024
    Chowdhury NS; Chang WJ; Cavaleri R; Chiang AKI; Schabrun SM, 2024, 'The reliability and validity of rapid transcranial magnetic stimulation mapping for muscles under active contraction', BMC Neuroscience, 25, http://dx.doi.org/10.1186/s12868-024-00885-w
    Journal articles | 2024
    Jenkins LC; Chang WJ; Humburg P; Wasinger VC; Stone LS; Dorsey SG; Renn C; Starkweather A; Schabrun SM, 2024, 'Sex Differences in the Serum Proteomic Profile During Acute Low Back Pain—A Preliminary Study of the Relationship to Future Low Back Pain', Journal of Pain, 25, http://dx.doi.org/10.1016/j.jpain.2023.11.009
    Journal articles | 2024
    Millard SK; Speis DB; Skippen P; Chiang AKI; Chang WJ; Lin AJ; Furman AJ; Mazaheri A; Seminowicz DA; Schabrun SM, 2024, 'Can non-invasive brain stimulation modulate peak alpha frequency in the human brain? A systematic review and meta-analysis', European Journal of Neuroscience, 60, pp. 4182 - 4200, http://dx.doi.org/10.1111/ejn.16424
    Journal articles | 2023
    Chang WJ; Jenkins LC; Humburg P; Schabrun SM, 2023, 'Human assumed central sensitization in people with acute non-specific low back pain: A cross-sectional study of the association with brain-derived neurotrophic factor, clinical, psychological and demographic factors', European Journal of Pain (United Kingdom), 27, pp. 530 - 545, http://dx.doi.org/10.1002/ejp.2078
    Journal articles | 2023
    Chang WJ; Jenkins LC; Humburg P; Wasinger V; Walton DM; Schabrun SM, 2023, 'Systemic pro- and anti-inflammatory profiles in acute non-specific low back pain: An exploratory longitudinal study of the relationship to six-month outcome', PLoS ONE, 18, http://dx.doi.org/10.1371/journal.pone.0287192
    Journal articles | 2023
    Chowdhury NS; Chiang AKI; Millard SK; Skippen P; Chang W-J; Seminowicz DA; Schabrun SM, 2023, 'Combined transcranial magnetic stimulation and electroencephalography reveals alterations in cortical excitability during pain', eLife, 12, http://dx.doi.org/10.7554/elife.88567.3
    Journal articles | 2023
    Chowdhury NS; Chiang AKI; Millard SK; Skippen P; Chang WJ; Seminowicz DA; Schabrun SM, 2023, 'Combined transcranial magnetic stimulation and electroencephalography reveals alterations in cortical excitability during pain', eLife, 12, http://dx.doi.org/10.7554/eLife.88567
    Journal articles | 2023
    Cunningham CN; Jenkins LC; Chang WJ; McAuley JH; Schabrun SM, 2023, 'Relative and absolute reliability of somatosensory evoked potentials in response to non-noxious electrical stimulation of the paraspinal muscles in healthy participants at an interval of 3-months', International Journal of Neuroscience, 133, pp. 103 - 109, http://dx.doi.org/10.1080/00207454.2021.1893722
    Journal articles | 2023
    Jenkins LC; Chang WJ; Buscemi V; Liston M; Humburg P; Nicholas M; Graven-Nielsen T; Hodges PW; McAuley JH; Schabrun SM, 2023, 'Cortical function and sensorimotor plasticity are prognostic factors associated with future low back pain after an acute episode: The Understanding persistent Pain Where it ResiDes prospective cohort study', Pain, 164, pp. 14 - 26, http://dx.doi.org/10.1097/j.pain.0000000000002684
    Journal articles | 2023
    Jenkins LC; Chang WJ; Buscemi V; Liston M; Nicholas M; Graven-Nielsen T; Hodges PW; Wasinger VC; Stone LS; Dorsey SG; McAuley JH; Schabrun SM, 2023, 'The Understanding Persistent Pain Where it ResiDes Study of Low Back Pain Cohort Profile', New Zealand Journal of Physiotherapy, 51, pp. 199 - 216, http://dx.doi.org/10.15619/nzjp.v51i3.375
    Journal articles | 2023
    Moukhaiber N; Summers SJ; Opar D; Imam J; Thomson D; Chang WJ; Andary T; Cavaleri R, 2023, 'The Effect of Theta Burst Stimulation Over the Primary Motor Cortex on Experimental Hamstring Pain: A Randomized, Controlled Study', Journal of Pain, 24, pp. 593 - 604, http://dx.doi.org/10.1016/j.jpain.2022.11.013
    Journal articles | 2022
    Adie S; Griffin XL; Harris IA; Gorelik A; Chang WJ, 2022, 'Surgical (percutaneous pinning or plate fixation) versus non-surgical interventions for distal radius fractures in adults: an individual participant data review', Cochrane Database of Systematic Reviews, 2022, http://dx.doi.org/10.1002/14651858.CD014933
    Journal articles | 2022
    Chang WJ; Adie S; Naylor JM; Chowdhury N; Finn H; Rizzo RRN; O'Hagan E; Schabrun SM, 2022, 'Feasibility and safety of combining repetitive transcranial magnetic stimulation and quadriceps strengthening exercise for chronic pain in knee osteoarthritis: A study protocol for a pilot randomised controlled trial', BMJ Open, 12, pp. e062577, http://dx.doi.org/10.1136/bmjopen-2022-062577
    Journal articles | 2022
    Chang WJ; Naylor J; Natarajan P; Liu V; Adie S, 2022, 'Evaluating methodological quality of prognostic prediction models on patient reported outcome measurements after total hip replacement and total knee replacement surgery: a systematic review protocol', Systematic Reviews, 11, http://dx.doi.org/10.1186/s13643-022-02039-7
    Journal articles | 2022
    Chowdhury NS; Chang WJ; Millard SK; Skippen P; Bilska K; Seminowicz DA; Schabrun SM, 2022, 'The Effect of Acute and Sustained Pain on Corticomotor Excitability: A Systematic Review and Meta-Analysis of Group and Individual Level Data', Journal of Pain, 23, pp. 1680 - 1696, http://dx.doi.org/10.1016/j.jpain.2022.04.012
    Journal articles | 2022
    Chowdhury NS; Rogasch NC; Chiang AKI; Millard SK; Skippen P; Chang WJ; Bilska K; Si E; Seminowicz DA; Schabrun SM, 2022, 'The influence of sensory potentials on transcranial magnetic stimulation – Electroencephalography recordings', Clinical Neurophysiology, 140, pp. 98 - 109, http://dx.doi.org/10.1016/j.clinph.2022.05.015
    Journal articles | 2022
    Hesam-Shariati N; Chang WJ; Wewege MA; McAuley JH; Booth A; Trost Z; Lin CT; Newton-John T; Gustin SM, 2022, 'The analgesic effect of electroencephalographic neurofeedback for people with chronic pain: A systematic review and meta-analysis', European Journal of Neurology, 29, pp. 921 - 936, http://dx.doi.org/10.1111/ene.15189
    Journal articles | 2022
    Jenkins LC; Chang WJ; Buscemi V; Liston M; Skippen P; Cashin AG; McAuley JH; Schabrun SM, 2022, 'Low Somatosensory Cortex Excitability in the Acute Stage of Low Back Pain Causes Chronic Pain', Journal of Pain, 23, pp. 289 - 304, http://dx.doi.org/10.1016/j.jpain.2021.08.003
    Journal articles | 2022
    Moukhaiber N; Summers S; Chang W; Andary T; Imam S; Thomson D; Cavaleri R, 2022, 'Investigating the effects of Theta Burst Stimulation (TBS) on experimentally-induced hamstring pain (vol 24, pg S27, 2021)', JOURNAL OF SCIENCE AND MEDICINE IN SPORT, 25, pp. E5 - E5, http://dx.doi.org/10.1016/j.jsams.2021.09.073
    Journal articles | 2021
    Jenkins L; Chang W-J; Buscemi V; Liston M; Skippen P; Cashin A; McAuley J; Schabrun S, 2021, 'Low somatosensory cortex excitability in the acute stage of low back pain causes chronic pain', , http://dx.doi.org/10.1101/2021.02.18.21251719
    Journal articles | 2020
    Chang WJ; Buscemi V; Liston MB; McAuley JH; Schabrun SM, 2020, 'Central pain processing does not differ between first episode and recurrent acute low back pain', Physiotherapy Practice and Research, 41, pp. 35 - 42, http://dx.doi.org/10.3233/PPR-190143
    Journal articles | 2020
    Hesam-Shariati N; Chang W-J; McAuley JH; Booth A; Trost Z; Lin C-T; Newton-John T; Gustin SM, 2020, 'The Analgesic Effect of Electroencephalographic Neurofeedback for People With Chronic Pain: Protocol for a Systematic Review and Meta-analysis (Preprint)', , http://dx.doi.org/10.2196/preprints.22821
    Journal articles | 2020
    Hesam-Shariati N; Chang WJ; McAuley JH; Booth A; Trost Z; Lin CT; Newton-John T; Gustin SM, 2020, 'The analgesic effect of electroencephalographic neurofeedback for people with chronic pain: Protocol for a systematic review and meta-analysis', JMIR Research Protocols, 9, pp. e22821, http://dx.doi.org/10.2196/22821
    Journal articles | 2019
    Buscemi V; Chang WJ; Liston MB; McAuley JH; Schabrun SM, 2019, 'The Role of Perceived Stress and Life Stressors in the Development of Chronic Musculoskeletal Pain Disorders: A Systematic Review', Journal of Pain, 20, pp. 1127 - 1139, http://dx.doi.org/10.1016/j.jpain.2019.02.008
    Journal articles | 2019
    Chang WJ; Buscemi V; Liston MB; McAuley JH; Hodges PW; Schabrun SM, 2019, 'Sensorimotor Cortical Activity in Acute Low Back Pain: A Cross-Sectional Study', Journal of Pain, 20, pp. 819 - 829, http://dx.doi.org/10.1016/j.jpain.2019.01.006
    Journal articles | 2019
    Jenkins L; Chang WJ; Buscemi V; Cunningham C; Cashin A; Mcauley JH; Liston M; Schabrun SM, 2019, 'Is there a causal relationship between acute stage sensorimotor cortex activity and the development of chronic low back pain? a protocol and statistical analysis plan', BMJ Open, 9, http://dx.doi.org/10.1136/bmjopen-2019-035792
    Journal articles | 2019
    Jenkins LC; Chang WJ; Buscemi V; Liston M; Toson B; Nicholas M; Graven-Nielsen T; Ridding M; Hodges PW; McAuley JH; Schabrun SM, 2019, 'Do sensorimotor cortex activity, an individual's capacity for neuroplasticity, and psychological features during an episode of acute low back pain predict outcome at 6 months: A protocol for an Australian, multisite prospective, longitudinal cohort study', BMJ Open, 9, http://dx.doi.org/10.1136/bmjopen-2019-029027
    Journal articles | 2018
    Chang WJ; O'Connell NE; Beckenkamp PR; Alhassani G; Liston MB; Schabrun SM, 2018, 'Altered Primary Motor Cortex Structure, Organization, and Function in Chronic Pain: A Systematic Review and Meta-Analysis', Journal of Pain, 19, pp. 341 - 359, http://dx.doi.org/10.1016/j.jpain.2017.10.007
    Journal articles | 2017
    Buscemi V; Chang WJ; Liston MB; McAuley JH; Schabrun S, 2017, 'The role of psychosocial stress in the development of chronic musculoskeletal pain disorders: Protocol for a systematic review and meta-analysis', Systematic Reviews, 6, pp. 224, http://dx.doi.org/10.1186/s13643-017-0618-0
    Journal articles | 2017
    Chang WJ; Bennell KL; Hodges PW; Hinman RS; Young CL; Buscemi V; Liston MB; Schabrun SM, 2017, 'Addition of transcranial direct current stimulation to quadriceps strengthening exercise in knee osteoarthritis: A pilot randomised controlled trial', PLoS ONE, 12, http://dx.doi.org/10.1371/journal.pone.0180328
    Journal articles | 2017
    Ouellette AL; Liston MB; Chang WJ; Walton DM; Wand BM; Schabrun SM, 2017, 'Safety and feasibility of transcranial direct current stimulation (tDCS) combined with sensorimotor retraining in chronic low back pain: A protocol for a pilot randomised controlled trial', BMJ Open, 7, http://dx.doi.org/10.1136/bmjopen-2016-013080
    Journal articles | 2015
    Chang WJ; Bennell KL; Hodges PW; Hinman RS; Liston MB; Schabrun SM, 2015, 'Combined Exercise and transcranial direct current stimulation intervention for knee osteoarthritis: Protocol for a pilot randomised controlled trial', BMJ Open, 5, http://dx.doi.org/10.1136/bmjopen-2015-008482
    Journal articles | 2015
    Chang WJ; O'Connell NE; Burns E; Chipchase LS; Liston MB; Schabrun SM, 2015, 'Organisation and function of the primary motor cortex in chronic pain: protocol for a systematic review and meta-analysis', BMJ Open, 5, http://dx.doi.org/10.1136/BMJOPEN-2015-008540
    Journal articles | 2012
    Chang WJ, 2012, 'Active Straight Leg Raise', Journal of Physiotherapy, 58, pp. 132, http://dx.doi.org/10.1016/S1836-9553(12)70098-X
  • Preprints | 2024
    Chowdhury NS; Taseen K; Chiang A; Chang W-J; Millard SK; Seminowicz DA; Schabrun SM, 2024, A 5-day course of rTMS before pain onset ameliorates future pain and increases sensorimotor peak alpha frequency., http://dx.doi.org/10.1101/2024.06.11.598596
    Preprints | 2024
    Millard S; Chiang AKI; Chowdhury N; Chang W-J; Furman A; De Martino E; Graven-Nielsen T; Schabrun S; Seminowicz D, 2024, Peak alpha frequency is not significantly altered by five days of experimental pain and repetitive transcranial stimulation of the left dorsolateral prefrontal cortex, http://dx.doi.org/10.1101/2024.06.14.599003
    Preprints | 2023
    Chowdhury NS; Chiang AK; Millard SK; Skippen P; Chang W-J; Seminowicz DA; Schabrun SM, 2023, Alterations in cortical excitability during pain: A combined TMS-EEG Study., http://dx.doi.org/10.1101/2023.04.20.537735
    Preprints | 2023
    Chowdhury NS; Chiang AKI; Millard SK; Skippen P; Chang W-J; Seminowicz DA; Schabrun SM, 2023, Alterations in cortical excitability during pain: A combined TMS-EEG Study, http://dx.doi.org/10.7554/elife.88567.2
    Preprints | 2023
    Millard SK; Speis DB; Skippen P; Chiang AKI; Chang WJ; Lin AJ; Furman AJ; Mazaheri A; Seminowicz DA; Schabrun SM, 2023, Can non-invasive brain stimulation modulate peak alpha frequency in the human brain? A systematic review and meta-analysis, http://dx.doi.org/10.1101/2023.11.13.566909
    Preprints | 2021
    Chang W-J; Naylor J; Liu V; Monuja M; Adie S, 2021, Preoperative optimisation in fast-track and enhanced recovery after surgery (ERAS) programs for total hip and knee joint replacement: a systematic review protocol, http://dx.doi.org/10.1101/2021.09.27.21264189
    Preprints | 2021
    Chang W-J; Naylor J; Natarajan P; Menounos S; Monuja M; Adie S, 2021, Evaluating Methodological Quality of Prognostic Prediction Models on Patient Reported Outcome Measurements after Total Hip Replacement and Total Knee Replacement Surgery: a systematic review protocol, http://dx.doi.org/10.21203/rs.3.rs-903247/v1
    Preprints | 2021
    Chowdhury N; Rogasch N; Chiang A; Millard S; Skippen P; Chang W-J; Bilska K; Si E; Seminowicz D; Schabrun S, 2021, The influence of somatosensory and auditory evoked potentials on concurrent transcranial-magnetic stimulation – electroencephalography recordings, http://dx.doi.org/10.1101/2021.11.17.469035
    Preprints | 2021
    Jenkins L; Chang W-J; Buscemi V; Liston M; Humburg P; Nicholas M; Graven-Nielsen T; Hodges P; McAuley J; Schabrun S, 2021, Cortical function and sensorimotor plasticity predict future low back pain after an acute episode: the UPWaRD prospective cohort study, http://dx.doi.org/10.1101/2021.07.14.21260552
    Preprints | 2021
    Jenkins L; Chang W-J; Buscemi V; Liston M; Nicholas M; Graven-Nielsen T; Hodges P; Wasinger V; Stone L; Dorsey S; McAuley J; Schabrun S, 2021, The Understanding persistent Pain Where it ResiDes study of low back pain cohort profile, http://dx.doi.org/10.1101/2021.11.24.21266794
    Preprints | 2020
    Chowdhury N; Chang W-J; Millard S; Skippen P; Bilska K; Seminowicz D; Schabrun S, 2020, The Influence of Experimental Pain on Primary Motor Cortex Function: Protocol for a Systematic Review and Meta-analysis, http://dx.doi.org/10.21203/rs.3.rs-33009/v1

Grants and funds received in the last five years – total AUD$49212.35

2019- Physiotherapy Research Foundation Seeding Grant (CIA). Chang WJ, Schabrun SM, Naylor J and Gibson K. “Why Does Quadriceps Weakness Persist after Total Knee Replacement? An Exploratory Investigation of Neuroplastic Mechanisms”. AUD$9511.

2021- Australia & New Zealand Musculoskeletal (ANZMUSC) Clinical Trials Network Seeding Grant (CIA). Chang WJ, Schabrun SM, Naylor JM and Adie S. “Repetitive Transcranial Magnetic Stimulation to Bolster Analgesic Effects of Exercise in Knee Osteoarthritis”. AUD$20000.

2022 The University of Newcastle College of Health, Medicine and Wellbeing Strategic Research Pilot Grant (CIA). Chang WJ, Breakspear M, Schabrun SM, Naylor JM and Adie S. “Exploratory investigation of novel brain biomarkers for predicting chronic postsurgical pain.” AUD$9783.3. 

2022 The University of Newcastle College of Health, Medicine and Wellbeing Research Start-Up Fund- AUD$4918.05.

2023 The University of Newcastle Pilot Research Fund (CIA). Chang WJ, Breakspear M, Schabrun SM.

“Investigation of the mechanisms underlying analgesic effects of repetitive transcranial magnetic stimulation.” AUD$5000.

Scholarships

  • 2014 Western Sydney University PhD Scholarship
  • 2015-2017 NHMRC Postgraduate Scholarship

 

  1. Marie Hammond Postgraduate Award for the highest academic achievement on completion of the Master program at University of South Australia in 2005
  2. Financial Aid Award by the International Association for the Study of Pain to attend and present at the World Congress on Pain in 2016
  3. Financial Aid Award by the International Association for the Study of Pain to attend and present at the World Congress on Pain in 2018

I am passionate about better understand chronic pain and developing new treatments for treating chronic pain. My research focuses on investigating physiological mechanisms of the development of chronic pain (including low back pain, post-surgical pain) and novel treatments for treating chronic pain. I am highly experienced in using neurophysiological techniques such as transcranial magnetic stimulation, electroencephalography, electromyography and quantitative sensory testing.

I have led clinical trials to test novel pain treatments: 2 pilot clinical trials were completed to examine the effects of adding transcranial direct current stimulation current and repetitive transcranial magnetic stimulation to strengthening exercise in knee osteoarthritis. I have published 30 peer-reviewed papers in high impact journals such as Cochrane Database of Systematic Reviews, eLife, Pain and Journal of Pain.