Associate Professor Wei Wen
Associate Professor

Associate Professor Wei Wen

BE, Ph.D.

Medicine & Health
Centre for Healthy Brain Ageing

Research Interests:
Computational neuroanatomy is about a comprehensive structural and functional model of the brain. The distribution of structural changes of human brain reflects the underlying pathology. The increasing sophistication of MRI allows neuroanatomical structures to be visualized in vivo in unprecedented detail. Clinical MRI is able to give good soft-tissue contrast and high spatial (<1 mm) resolution. Due to rapid advances in computing power and algorithm development, we are now well placed to study the extraordinary MRI-visible morphological variability of the human brain through mathematical models sensitive to subtle changes in neuroanatomical shape, complexity and tissue characteristics. One of the key requirements of neuroimaging research is the multi-disciplinary collaborations between neuroscience, engineering and medicine and a host of sub-disciplines. While the research subjects and the clinical needs are provided by medicine, the theoretical underpinnings come from mathematics and statistics, and the methodological approaches from computer science and biomedical engineering, all forming critical components of the enterprise. Our recent work includes mapping and modeling of cerebral white matter hyperintensities, algorithm development for examining the shapes and sizes of brain structures and cortical atrophy. fMRI, pMRI, MRS, and PET are also currently being used as brain imaging modalities in various studies.

Broad Research Areas:
Neurosciences, Brain Ageing, NeuroImaging / Neuro-radiology, Medical Informatics, Pattern Recognition & Data Mining, Markov models

Qualifications:
Ph.D. (Engineering, Sydney University)

Specific Research Keywords:
Computational neuroanatomy, Brain Anatomy, MRI, Mathematical Modelling, Medical Imaging

Meet Our Researcher
Click here to read Associate Professor Wei Wen's ‘Meet Our Researcher’ interview

Phone
+61 2 9385 0438
Location
Centre for Healthy Brain Ageing, Level 1, AGSM Building UNSW Sydney 2052, NSW
  • Journal articles | 2022
    Dima D; Modabbernia A; Papachristou E; Doucet GE; Agartz I; Aghajani M; Akudjedu TN; Albajes-Eizagirre A; Alnæs D; Alpert KI; Andersson M; Andreasen NC; Andreassen OA; Asherson P; Banaschewski T; Bargallo N; Baumeister S; Baur-Streubel R; Bertolino A; Bonvino A; Boomsma DI; Borgwardt S; Bourque J; Brandeis D; Breier A; Brodaty H; Brouwer RM; Buitelaar JK; Busatto GF; Buckner RL; Calhoun V; Canales-Rodríguez EJ; Cannon DM; Caseras X; Castellanos FX; Cervenka S; Chaim-Avancini TM; Ching CRK; Chubar V; Clark VP; Conrod P; Conzelmann A; Crespo-Facorro B; Crivello F; Crone EA; Dannlowski U; Dale AM; Davey C; de Geus EJC; de Haan L; de Zubicaray GI; den Braber A; Dickie EW; Di Giorgio A; Doan NT; Dørum ES; Ehrlich S; Erk S; Espeseth T; Fatouros-Bergman H; Fisher SE; Fouche JP; Franke B; Frodl T; Fuentes-Claramonte P; Glahn DC; Gotlib IH; Grabe HJ; Grimm O; Groenewold NA; Grotegerd D; Gruber O; Gruner P; Gur RE; Gur RC; Hahn T; Harrison BJ; Hartman CA; Hatton SN; Heinz A; Heslenfeld DJ; Hibar DP; Hickie IB; Ho BC; Hoekstra PJ; Hohmann S; Holmes AJ; Hoogman M; Hosten N; Howells FM; Hulshoff Pol HE; Huyser C; Jahanshad N; James A; Jernigan TL; Jiang J; Jönsson EG; Joska JA; Kahn R; Kalnin A, 2022, 'Subcortical volumes across the lifespan: Data from 18,605 healthy individuals aged 3–90 years', Human Brain Mapping, vol. 43, pp. 452 - 469, http://dx.doi.org/10.1002/hbm.25320
    Journal articles | 2022
    Dong C; Thalamuthu A; Jiang J; Mather KA; Brodaty H; Sachdev PS; Wen W, 2022, 'Parental Life Span and Polygenic Risk Score of Longevity Are Associated With White Matter Hyperintensities', Journals of Gerontology - Series A Biological Sciences and Medical Sciences, vol. 77, pp. 689 - 696, http://dx.doi.org/10.1093/gerona/glab323
    Journal articles | 2022
    Hairu R; Close JCT; Lord SR; Delbaere K; Wen W; Jiang J; Taylor ME, 2022, 'The association between white matter hyperintensity volume and cognitive/physical decline in older people with dementia: A one-year longitudinal study', Aging and Mental Health, vol. 26, pp. 2503 - 2510, http://dx.doi.org/10.1080/13607863.2021.1980859
    Journal articles | 2022
    Koncz R; Thalamuthu A; Wen W; Catts VS; Dore V; Lee T; Mather KA; Slavin MJ; Wegner EA; Jiang J; Trollor JN; Ames D; Villemagne VL; Rowe CC; Sachdev PS, 2022, 'The heritability of amyloid burden in older adults: the Older Australian Twins Study', Journal of neurology, neurosurgery, and psychiatry, vol. 93, pp. 303 - 308, http://dx.doi.org/10.1136/jnnp-2021-326677
    Journal articles | 2022
    Li X; Zhao Y; Jiang J; Cheng J; Zhu W; Wu Z; Jing J; Zhang Z; Wen W; Sachdev PS; Wang Y; Liu T; Li Z, 2022, 'White matter hyperintensities segmentation using an ensemble of neural networks', Human Brain Mapping, vol. 43, pp. 929 - 939, http://dx.doi.org/10.1002/hbm.25695
    Journal articles | 2022
    Sønderby IE; Ching CRK; Thomopoulos SI; van der Meer D; Sun D; Villalon-Reina JE; Agartz I; Amunts K; Arango C; Armstrong NJ; Ayesa-Arriola R; Bakker G; Bassett AS; Boomsma DI; Bülow R; Butcher NJ; Calhoun VD; Caspers S; Chow EWC; Cichon S; Ciufolini S; Craig MC; Crespo-Facorro B; Cunningham AC; Dale AM; Dazzan P; de Zubicaray GI; Djurovic S; Doherty JL; Donohoe G; Draganski B; Durdle CA; Ehrlich S; Emanuel BS; Espeseth T; Fisher SE; Ge T; Glahn DC; Grabe HJ; Gur RE; Gutman BA; Haavik J; Håberg AK; Hansen LA; Hashimoto R; Hibar DP; Holmes AJ; Hottenga JJ; Hulshoff Pol HE; Jalbrzikowski M; Knowles EEM; Kushan L; Linden DEJ; Liu J; Lundervold AJ; Martin-Brevet S; Martínez K; Mather KA; Mathias SR; McDonald-McGinn DM; McRae AF; Medland SE; Moberget T; Modenato C; Monereo Sánchez J; Moreau CA; Mühleisen TW; Paus T; Pausova Z; Prieto C; Ragothaman A; Reinbold CS; Reis Marques T; Repetto GM; Reymond A; Roalf DR; Rodriguez-Herreros B; Rucker JJ; Sachdev PS; Schmitt JE; Schofield PR; Silva AI; Stefansson H; Stein DJ; Tamnes CK; Tordesillas-Gutiérrez D; Ulfarsson MO; Vajdi A; van 't Ent D; van den Bree MBM; Vassos E; Vázquez-Bourgon J; Vila-Rodriguez F; Walters GB; Wen W; Westlye LT; Wittfeld K; Zackai EH; Stefánsson K; Jacquemont S, 2022, 'Effects of copy number variations on brain structure and risk for psychiatric illness: Large-scale studies from the ENIGMA working groups on CNVs', Human Brain Mapping, vol. 43, pp. 300 - 328, http://dx.doi.org/10.1002/hbm.25354
    Journal articles | 2022
    Wierenga LM; Doucet GE; Dima D; Agartz I; Aghajani M; Akudjedu TN; Albajes-Eizagirre A; Alnæs D; Alpert KI; Andreassen OA; Anticevic A; Asherson P; Banaschewski T; Bargallo N; Baumeister S; Baur-Streubel R; Bertolino A; Bonvino A; Boomsma DI; Borgwardt S; Bourque J; den Braber A; Brandeis D; Breier A; Brodaty H; Brouwer RM; Buitelaar JK; Busatto GF; Calhoun VD; Canales-Rodríguez EJ; Cannon DM; Caseras X; Castellanos FX; Chaim-Avancini TM; Ching CRK; Clark VP; Conrod PJ; Conzelmann A; Crivello F; Davey CG; Dickie EW; Ehrlich S; van't Ent D; Fisher SE; Fouche JP; Franke B; Fuentes-Claramonte P; de Geus EJC; Di Giorgio A; Glahn DC; Gotlib IH; Grabe HJ; Gruber O; Gruner P; Gur RE; Gur RC; Gurholt TP; de Haan L; Haatveit B; Harrison BJ; Hartman CA; Hatton SN; Heslenfeld DJ; van den Heuvel OA; Hickie IB; Hoekstra PJ; Hohmann S; Holmes AJ; Hoogman M; Hosten N; Howells FM; Hulshoff Pol HE; Huyser C; Jahanshad N; James AC; Jiang J; Jönsson EG; Joska JA; Kalnin AJ; Klein M; Koenders L; Kolskår KK; Krämer B; Kuntsi J; Lagopoulos J; Lazaro L; Lebedeva IS; Lee PH; Lochner C; Machielsen MWJ; Maingault S; Martin NG; Martínez-Zalacaín I; Mataix-Cols D; Mazoyer B; McDonald BC; McDonald C; McIntosh AM; McMahon KL; McPhilemy G, 2022, 'Greater male than female variability in regional brain structure across the lifespan', Human Brain Mapping, vol. 43, pp. 470 - 499, http://dx.doi.org/10.1002/hbm.25204
    Journal articles | 2021
    Alqarni A; Jiang J; Crawford JD; Koch F; Brodaty H; Sachdev P; Wen W, 2021, 'Sex differences in risk factors for white matter hyperintensities in non-demented older individuals', Neurobiology of Aging, vol. 98, pp. 197 - 204, http://dx.doi.org/10.1016/j.neurobiolaging.2020.11.001
    Journal articles | 2021
    Cheng J; Liu Z; Guan H; Wu Z; Zhu H; Jiang J; Wen W; Tao D; Liu T, 2021, 'Brain Age Estimation from MRI Using Cascade Networks with Ranking Loss', IEEE Transactions on Medical Imaging, vol. 40, pp. 3400 - 3412, http://dx.doi.org/10.1109/TMI.2021.3085948
    Journal articles | 2021
    Doborjeh M; Doborjeh Z; Merkin A; Bahrami H; Sumich A; Krishnamurthi R; Medvedev ON; Crook-Rumsey M; Morgan C; Kirk I; Sachdev PS; Brodaty H; Kang K; Wen W; Feigin V; Kasabov N, 2021, 'Personalised predictive modelling with brain-inspired spiking neural networks of longitudinal MRI neuroimaging data and the case study of dementia', Neural Networks, vol. 144, pp. 522 - 539, http://dx.doi.org/10.1016/j.neunet.2021.09.013
    Journal articles | 2021
    Du J; Koch FC; Xia A; Jiang J; Crawford JD; Lam BCP; Thalamuthu A; Lee T; Kochan N; Fawns-Ritchie C; Brodaty H; Xu Q; Sachdev PS; Wen W, 2021, 'Difference in distribution functions: A new diffusion weighted imaging metric for estimating white matter integrity', NeuroImage, vol. 240, pp. 118381, http://dx.doi.org/10.1016/j.neuroimage.2021.118381
    Journal articles | 2021
    Foo H; Thalamuthu A; Jiang J; Koch F; Mather KA; Wen W; Sachdev PS, 2021, 'Age- and Sex-Related Topological Organization of Human Brain Functional Networks and Their Relationship to Cognition', Frontiers in Aging Neuroscience, vol. 13, pp. 758817, http://dx.doi.org/10.3389/fnagi.2021.758817
    Journal articles | 2021
    Foo H; Thalamuthu A; Jiang J; Koch F; Mather KA; Wen W; Sachdev PS, 2021, 'Associations between Alzheimer's disease polygenic risk scores and hippocampal subfield volumes in 17,161 UK Biobank participants', Neurobiology of Aging, vol. 98, pp. 108 - 115, http://dx.doi.org/10.1016/j.neurobiolaging.2020.11.002
    Journal articles | 2021
    Foo H; Thalamuthu A; Jiang J; Koch FC; Mather KA; Wen W; Sachdev PS, 2021, 'Novel genetic variants associated with brain functional networks in 18,445 adults from the UK Biobank', Scientific Reports, vol. 11, pp. 14633, http://dx.doi.org/10.1038/s41598-021-94182-9
    Journal articles | 2021
    Geng C; Sun T; Wang Z; Wu JM; Gu YJ; Kobayashi H; Yang P; Hai J; Wen W, 2021, 'Surface-Induced Desolvation of Hydronium Ion Enables Anatase TiO2as an Efficient Anode for Proton Batteries', Nano Letters, vol. 21, pp. 7021 - 7029, http://dx.doi.org/10.1021/acs.nanolett.1c02421
    Journal articles | 2021
    Hairu R; Close JCT; Lord SR; Delbaere K; Wen W; Jiang J; Taylor ME, 2021, 'The association between white matter hyperintensity volume and gait performance under single and dual task conditions in older people with dementia: A cross-sectional study', Archives of Gerontology and Geriatrics, vol. 95, pp. 104427, http://dx.doi.org/10.1016/j.archger.2021.104427
    Journal articles | 2021
    Jia T; Chu C; Liu Y; van Dongen J; Papastergios E; Armstrong NJ; Bastin ME; Carrillo-Roa T; den Braber A; Harris M; Jansen R; Liu J; Luciano M; Ori APS; Roiz Santiañez R; Ruggeri B; Sarkisyan D; Shin J; Sungeun K; Tordesillas Gutiérrez D; van’t Ent D; Ames D; Artiges E; Bakalkin G; Banaschewski T; Bokde ALW; Brodaty H; Bromberg U; Brouwer R; Büchel C; Burke Quinlan E; Cahn W; de Zubicaray GI; Ehrlich S; Ekström TJ; Flor H; Fröhner JH; Frouin V; Garavan H; Gowland P; Heinz A; Hoare J; Ittermann B; Jahanshad N; Jiang J; Kwok JB; Martin NG; Martinot JL; Mather KA; McMahon KL; McRae AF; Nees F; Papadopoulos Orfanos D; Paus T; Poustka L; Sämann PG; Schofield PR; Smolka MN; Stein DJ; Strike LT; Teeuw J; Thalamuthu A; Trollor J; Walter H; Wardlaw JM; Wen W; Whelan R; Apostolova LG; Binder EB; Boomsma DI; Calhoun V; Crespo-Facorro B; Deary IJ; Hulshoff Pol H; Ophoff RA; Pausova Z; Sachdev PS; Saykin A; Wright MJ; Thompson PM; Schumann G; Desrivières S, 2021, 'Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group', Molecular Psychiatry, vol. 26, pp. 3884 - 3895, http://dx.doi.org/10.1038/s41380-019-0605-z
    Journal articles | 2021
    Paradise M; Crawford JD; Lam BCP; Wen W; Kochan NA; Makkar S; Dawes L; Trollor J; Draper B; Brodaty H; Sachdev PS, 2021, 'Association of Dilated Perivascular Spaces With Cognitive Decline and Incident Dementia', Neurology, vol. 96, pp. E1501 - E1511, http://dx.doi.org/10.1212/WNL.0000000000011537
    Journal articles | 2021
    Shin J; Ma S; Hofer E; Patel Y; Vosberg DE; Tilley S; Roshchupkin GV; Sousa AMM; Jian X; Gottesman R; Mosley TH; Fornage M; Saba Y; Pirpamer L; Schmidt R; Schmidt H; Carrion-Castillo A; Crivello F; Mazoyer B; Bis JC; Li S; Yang Q; Luciano M; Karama S; Lewis L; Bastin ME; Harris MA; Wardlaw JM; Deary IE; Scholz M; Loeffler M; Witte AV; Beyer F; Villringer A; Armstrong NJ; Mather KA; Ames D; Jiang J; Kwok JB; Schofield PR; Thalamuthu A; Trollor JN; Wright MJ; Brodaty H; Wen W; Sachdev PS; Terzikhan N; Evans TE; Adams HHHH; Ikram MA; Frenzel S; van der Auwera-Palitschka S; Wittfeld K; Bülow R; Grabe HJ; Tzourio C; Mishra A; Maingault S; Debette S; Gillespie NA; Franz CE; Kremen WS; Ding L; Jahanshad N; Sestan N; Pausova Z; Seshadri S; Paus T, 2021, 'Global and regional development of the human cerebral cortex: Molecular architecture and occupational aptitudes', Cerebral Cortex, vol. 30, pp. 4121 - 4139, http://dx.doi.org/10.1093/CERCOR/BHAA035
    Journal articles | 2021
    Sønderby IE; van der Meer D; Moreau C; Kaufmann T; Walters GB; Ellegaard M; Abdellaoui A; Ames D; Amunts K; Andersson M; Armstrong NJ; Bernard M; Blackburn NB; Blangero J; Boomsma DI; Brodaty H; Brouwer RM; Bülow R; Bøen R; Cahn W; Calhoun VD; Caspers S; Ching CRK; Cichon S; Ciufolini S; Crespo-Facorro B; Curran JE; Dale AM; Dalvie S; Dazzan P; de Geus EJC; de Zubicaray GI; de Zwarte SMC; Desrivieres S; Doherty JL; Donohoe G; Draganski B; Ehrlich S; Eising E; Espeseth T; Fejgin K; Fisher SE; Fladby T; Frei O; Frouin V; Fukunaga M; Gareau T; Ge T; Glahn DC; Grabe HJ; Groenewold NA; Gústafsson Ó; Haavik J; Haberg AK; Hall J; Hashimoto R; Hehir-Kwa JY; Hibar DP; Hillegers MHJ; Hoffmann P; Holleran L; Holmes AJ; Homuth G; Hottenga JJ; Hulshoff Pol HE; Ikeda M; Jahanshad N; Jockwitz C; Johansson S; Jönsson EG; Jørgensen NR; Kikuchi M; Knowles EEM; Kumar K; Le Hellard S; Leu C; Linden DEJ; Liu J; Lundervold A; Lundervold AJ; Maillard AM; Martin NG; Martin-Brevet S; Mather KA; Mathias SR; McMahon KL; McRae AF; Medland SE; Meyer-Lindenberg A; Moberget T; Modenato C; Sánchez JM; Morris DW; Mühleisen TW; Murray RM; Nielsen J; Nordvik JE; Nyberg L; Loohuis LMO; Ophoff RA, 2021, '1q21.1 distal copy number variants are associated with cerebral and cognitive alterations in humans', Translational Psychiatry, vol. 11, pp. 182, http://dx.doi.org/10.1038/s41398-021-01213-0
    Journal articles | 2021
    Wu W; He Z; Xu J; Wen W; Wang J; Zhu Q; Chen L, 2021, 'Anatomical Pulmonary Sublobar Resection Based on Subsegment', Annals of Thoracic Surgery, vol. 111, pp. e447 - e450, http://dx.doi.org/10.1016/j.athoracsur.2020.10.083
    Journal articles | 2021
    Yang W; Liu Z; Yang C; Liu S; Guo M; Wen W; Wang J; Liu C; Zhu Q, 2021, 'Combination of nitrous oxide and the modified inflation-deflation method for identifying the intersegmental plane in segmentectomy: A randomized controlled trial', Thoracic Cancer, vol. 12, pp. 1398 - 1406, http://dx.doi.org/10.1111/1759-7714.13919
    Journal articles | 2021
    Zhao H; Cheng J; Liu T; Jiang J; Koch F; Sachdev PS; Basser PJ; Wen W, 2021, 'Orientational changes of white matter fibers in Alzheimer's disease and amnestic mild cognitive impairment', Human Brain Mapping, vol. 42, pp. 5397 - 5408, http://dx.doi.org/10.1002/hbm.25628
    Journal articles | 2020
    Broadhouse KM; Singh MF; Suo C; Gates N; Wen W; Brodaty H; Jain N; Wilson GC; Meiklejohn J; Singh N; Baune BT; Baker M; Foroughi N; Wang Y; Kochan N; Ashton K; Brown M; Li Z; Mavros Y; Sachdev PS; Valenzuela M, 2020, 'Hippocampal plasticity underpins long-term cognitive gains from resistance exercise in MCI', NeuroImage: Clinical, vol. 25, pp. 102182 - 102182, http://dx.doi.org/10.1016/j.nicl.2020.102182
    Journal articles | 2020
    Brouwer R; Klein M; Grasby K; Schnack H; Jahanshad N; Teeuw J; Thomopoulos S; Sprooten E; Franz C; Gogtay N; Kremen W; Panizzon M; Olde Loohuis L; Whelan C; Aghajani M; Alloza C; Alnæs D; Artiges E; Ayesa-Arriola R; Barker G; Bastin M; Blok E; Bøen E; Breukelaar I; Bright J; Buimer E; Bülow R; Cannon D; Ciufolini S; Crossley N; Damatac C; Dazzan P; de Mol C; de Zwarte S; Desrivières S; Díaz-Caneja C; Doan NT; Dohm K; Fröhner J; Goltermann J; Grigis A; Grotegerd D; Han L; Harris M; Hartman C; Heany S; Heindel W; Heslenfeld D; Hohmann S; Ittermann B; Jansen P; Janssen J; Jia T; Jiang J; Jockwitz C; Karali T; Keeser D; Koevoets M; Lenroot R; Malchow B; Mandl R; Medel V; Meinert S; Morgan C; Mühleisen T; Nabulsi L; Opel N; de la Foz VO-G; Overs B; Martinot M-LP; Quinlan E; Redlich R; Marques TR; Repple J; Roberts G; Roshchupkin G; Setiaman N; Shumskaya E; Stein F; Sudre G; Takahashi S; Thalamuthu A; Tordesillas-Gutiérrez D; van der Lugt A; van Haren N; Wardlaw J; Wen W; Westeneng H-J; Wittfeld K; Zhu A; Zugman A; Armstrong N; Bonfiglio G; Bralten J; Dalvie S; Davies G; Di Forti M; Ding L; Donohoe G; Forstner A; Gonzalez-Peñas J; Guimaraes J; Homuth G; Hottenga J-J; Knol M; Kwok J; Le Hellard S; Mather K; Milaneschi Y; Morris D; Nöthen M; Papiol S; Rietschel M; Santoro M; Steen V; Stein J; Streit F; Tankard R; Teumer A; van ‘t Ent D; van der Meer D; van Eijk K; Vassos E; Vázquez-Bourgon J; Witt S; Adams H; Agartz I; Ames D; Amunts K; Andreassen O; Arango C; Banaschewski T; Baune B; Belangero S; Bokde A; Boomsma D; Bressan R; Brodaty H; Buitelaar J; Cahn W; Caspers S; Cichon S; Facorro BC; Cox S; Dannlowski U; Elvsåshagen T; Espeseth T; Falkai P; Fisher S; Flor H; Fullerton J; Garavan H; Gowland P; Gowland P; Grabe H; Hahn T; Heinz A; Hillegers M; Hoare J; Hoekstra P; Ikram M; Jackowski A; Jansen A; Jönsson E; Kahn R; Kircher T; Korgaonkar M; Krug A; Lemaitre H; Malt U; Martinot J-L; McDonald C; Mitchell P; Muetzel R; Murray R; Nees F; Nenadic I; Oosterlaan J; Ophoff R; Pan P; Penninx B; Poustka L; Sachdev P; Salum G; Schofield P; Schumann G; Shaw P; Sim K; Smolka M; Stein D; Trollor J; van den Berg L; Veldink J; Walter H; Westlye L; Whelan R; White T; Wright M; Medland S; Franke B; Thompson P; Hulshoff Pol H; Alzheimer’s Disease Neuroimaging Initiative ; the IMAGEN consortium , 2020, 'Age-dependent genetic variants associated with longitudinal changes in brain structure across the lifespan', , http://dx.doi.org/10.1101/2020.04.24.031138
    Journal articles | 2020
    Foo H; Thalamuthu A; Jiang J; Koch F; Mather K; Wen W; Sachdev P, 2020, 'Associations between Alzheimer’s disease polygenic risk scores and hippocampal subfield volumes in 17,161 UK Biobank participants', , http://dx.doi.org/10.1101/2020.10.24.20218925
    Journal articles | 2020
    Foo H; Thalamuthu A; Jiang J; Koch F; Mather K; Wen W; Sachdev P, 2020, 'Novel genetic variants associated with brain functional networks in 18,445 adults from the UK Biobank', , http://dx.doi.org/10.1101/2020.09.17.268029
    Journal articles | 2020
    Grasby KL; Jahanshad N; Painter JN; Colodro-Conde L; Bralten J; Hibar DP; Lind PA; Pizzagalli F; Ching CRK; McMahon MAB; Shatokhina N; Zsembik LCP; Thomopoulos SI; Zhu AH; Strike LT; Agartz I; Alhusaini S; Almeida MAA; Alnæs D; Amlien IK; Andersson M; Ard T; Armstrong NJ; Ashley-Koch A; Atkins JR; Bernard M; Brouwer RM; Buimer EEL; Bülow R; Bürger C; Cannon DM; Chakravarty M; Chen Q; Cheung JW; Couvy-Duchesne B; Dale AM; Dalvie S; de Araujo TK; de Zubicaray GI; de Zwarte SMC; den Braber A; Doan NT; Dohm K; Ehrlich S; Engelbrecht HR; Erk S; Fan CC; Fedko IO; Foley SF; Ford JM; Fukunaga M; Garrett ME; Ge T; Giddaluru S; Goldman AL; Green MJ; Groenewold NA; Grotegerd D; Gurholt TP; Gutman BA; Hansell NK; Harris MA; Harrison MB; Haswell CC; Hauser M; Herms S; Heslenfeld DJ; Ho NF; Hoehn D; Hoffmann P; Holleran L; Hoogman M; Hottenga JJ; Ikeda M; Janowitz D; Jansen IE; Jia T; Jockwitz C; Kanai R; Karama S; Kasperaviciute D; Kaufmann T; Kelly S; Kikuchi M; Klein M; Knapp M; Knodt AR; Krämer B; Lam M; Lancaster TM; Lee PH; Lett TA; Lewis LB; Lopes-Cendes I; Luciano M; Macciardi F; Marquand AF; Mathias SR; Melzer TR; Milaneschi Y, 2020, 'The genetic architecture of the human cerebral cortex', Science, vol. 367, http://dx.doi.org/10.1126/science.aay6690
    Journal articles | 2020
    Hofer E; Roshchupkin GV; Adams HHH; Knol MJ; Lin H; Li S; Zare H; Ahmad S; Armstrong NJ; Satizabal CL; Bernard M; Bis JC; Gillespie NA; Luciano M; Mishra A; Scholz M; Teumer A; Xia R; Jian X; Mosley TH; Saba Y; Pirpamer L; Seiler S; Becker JT; Carmichael O; Rotter JI; Psaty BM; Lopez OL; Amin N; van der Lee SJ; Yang Q; Himali JJ; Maillard P; Beiser AS; Decarli C; Karama S; Lewis L; Harris M; Bastin ME; Deary IJ; Witte AV; Beyer F; Loeffler M; Mather KA; Schofield PR; Thalamuthu A; Kwok JB; Wright MJ; Ames D; Trollor J; Jiang J; Brodaty H; Wen W; Vernooij MW; Hofman A; Uitterlinden AG; Niessen WJ; Wittfeld K; Bülow R; Völker U; Pausova Z; Pike GB; Maingault S; Crivello F; Tzourio C; Amouyel P; Mazoyer B; Neale MC; Franz CE; Lyons MJ; Panizzon MS; Andreassen OA; Dale AM; Logue M; Grasby KL; Jahanshad N; Painter JN; Colodro-Conde L; Bralten J; Hibar DP; Lind PA; Pizzagalli F; Stein JL; Thompson PM; Medland SE; Sachdev PS; Kremen WS; Wardlaw JM; Villringer A; van Duijn CM; Grabe HJ; Longstreth WT; Fornage M; Paus T; Debette S; Ikram MA; Schmidt H; Schmidt R; Seshadri S; Ching CRK, 2020, 'Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults', Nature Communications, vol. 11, http://dx.doi.org/10.1038/s41467-020-18367-y
    Journal articles | 2020
    Liu H; Liu T; Jiang J; Cheng J; Liu Y; Li D; Dong C; Niu H; Li S; Zhang J; Brodaty H; Sachdev P; Wen W, 2020, 'Differential longitudinal changes in structural complexity and volumetric measures in community-dwelling older individuals', Neurobiology of Aging, http://dx.doi.org/10.1016/j.neurobiolaging.2020.02.023
    Journal articles | 2020
    Liu Y; Chan DKY; Thalamuthu A; Wen W; Jiang J; Paradise M; Lee T; Crawford J; Wai Kin Wong M; Hua Xu Y; Poljak A; Pickford R; Sachdev PS; Braidy N, 2020, 'Plasma lipidomic biomarker analysis reveals distinct lipid changes in vascular dementia', Computational and Structural Biotechnology Journal, vol. 18, pp. 1613 - 1624, http://dx.doi.org/10.1016/j.csbj.2020.06.001
    Journal articles | 2020
    Samaras K; Makkar S; Crawford JD; Kochan NA; Wen W; Draper B; Trollor JN; Brodaty H; Sachdev PS, 2020, 'Metformin use is associated with slowed cognitive decline and reduced incident dementia in older adults with type 2 diabetes: The Sydney memory and ageing study', Diabetes Care, vol. 43, pp. 2691 - 2701, http://dx.doi.org/10.2337/dc20-0892
    Journal articles | 2020
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    Adams HHH; Hibar DP; Chouraki V; Stein JL; Nyquist PA; Rentería ME; Trompet S; Arias-Vasquez A; Seshadri S; Desrivières S; Beecham AH; Jahanshad N; Wittfeld K; Van Der Lee SJ; Abramovic L; Alhusaini S; Amin N; Andersson M; Arfanakis K; Aribisala BS; Armstrong NJ; Athanasiu L; Axelsson T; Beiser A; Bernard M; Bis JC; Blanken LME; Blanton SH; Bohlken MM; Boks MP; Bralten J; Brickman AM; Carmichael O; Chakravarty MM; Chauhan G; Chen Q; Ching CRK; Cuellar-Partida G; Braber AD; Doan NT; Ehrlich S; Filippi I; Ge T; Giddaluru S; Goldman AL; Gottesman RF; Greven CU; Grimm O; Griswold ME; Guadalupe T; Hass J; Haukvik UK; Hilal S; Hofer E; Hoehn D; Holmes AJ; Hoogman M; Janowitz D; Jia T; Kasperaviciute D; Kim S; Klein M; Kraemer B; Lee PH; Liao J; Liewald DCM; Lopez LM; Luciano M; Macare C; Marquand A; Matarin M; Mather KA; Mattheisen M; Mazoyer B; McKay DR; McWhirter R; Milaneschi Y; Mirza-Schreiber N; Muetzel RL; Maniega SM; Nho K; Nugent AC; Loohuis LMO; Oosterlaan J; Papmeyer M; Pappa I; Pirpamer L; Pudas S; Pütz B; Rajan KB; Ramasamy A; Richards JS; Risacher SL; Roiz-Santiañez R; Rommelse N; Rose EJ; Royle NA; Rundek T; Sämann PG; Satizabal CL, 2016, 'Novel genetic loci underlying human intracranial volume identified through genome-wide association', Nature Neuroscience, vol. 19, pp. 1569 - 1582, http://dx.doi.org/10.1038/nn.4398
    Journal articles | 2016
    Franke B; van Hulzen KJE; Arias-Vasquez A; Bralten J; Hoogman M; Klein M; van Donkelaar MMJ; Hakobjan MMH; Heister AJGAM; Makkinje RRR; Naber MAM; van der Marel SSL; Mostert JC; Brunner HG; van Bokhoven H; Zwiers MP; Buitelaar JK; Fernández G; Fisher SE; Francks C; Stein JL; Hibar DP; Thompson PM; Ripke S; Anttila V; Neale BM; Farh KH; Bulik-Sullivan B; Huang H; Fromer M; Goldstein JI; Daly MJ; Walters RK; Smoller JW; Lee P; Belliveau RA; Bergen SE; Bevilacqua E; Chambert KD; Genovese G; O'Dushlaine C; Scolnick EM; McCarroll SA; Moran JL; Palotie A; Petryshen TL; Erk S; Heinz A; Mohnke S; Romanczuk-Seiferth N; Walter H; DeLisi LE; McCarley RW; Mesholam-Gately RI; Seidman LJ; Nichols TE; Neale MC; McIntosh AM; Papmeyer M; Sprooten E; Lawrie SM; Sussmann JE; McMahon FJ; Yao Y; Meyer-Lindenberg A; Schwarz E; Grimm O; Mattheisen M; Agerbo E; Demontis D; Hansen T; Mors O; Olsen L; Rasmussen HB; Børglum AD; Mortensen PB; Werge T; Andreassen OA; Brown AA; Athanasiu L; Hartberg CB; Haukvik U; Melle I; Gruber O; Kraemer B; Keil M; Sachdev PS; Mather KA; Thalamuthu A; Armstrong NJ; Assareh AA; Brodaty H; Reppermund S; Wen W; Roiz-Santiañez R; Perez-Iglesias R; Saykin AJ; Kim S; Nho K; Risacher SL, 2016, 'Genetic influences on schizophrenia and subcortical brain volumes: Large-scale proof of concept', Nature Neuroscience, vol. 19, pp. 420 - 431, http://dx.doi.org/10.1038/nn.4228
    Journal articles | 2016
    Lupton MK; Strike L; Hansell NK; Wen W; Mather KA; Armstrong NJ; Thalamuthu A; McMahon KL; de Zubicaray GI; Assareh AA; Simmons A; Proitsi P; Powell JF; Montgomery GW; Hibar DP; Westman E; Tsolaki M; Kloszewska I; Soininen H; Mecocci P; Velas B; Lovestone S; Brodaty H; Ames D; Trollor JN; Martin NG; Thompson PM; Sachdev PS; Wright MJ, 2016, 'The effect of increased genetic risk for Alzheimer's disease on hippocampal and amygdala volume', Neurobiology of Aging, vol. 40, pp. 68 - 77, http://dx.doi.org/10.1016/j.neurobiolaging.2015.12.023
    Journal articles | 2016
    Roberts G; Lenroot R; Frankland A; Yeung PK; Gale N; Wright A; Lau P; Levy F; Wen W; Mitchell PB, 2016, 'Abnormalities in left inferior frontal gyral thickness and parahippocampal gyral volume in young people at high genetic risk for bipolar disorder', Psychological Medicine, vol. 46, pp. 2083 - 2096, http://dx.doi.org/10.1017/S0033291716000507
    Journal articles | 2016
    Suo C; Singh MF; Gates N; Wen W; Sachdev P; Brodaty H; Saigal N; Wilson GC; Meiklejohn J; Singh N; Baune BT; Baker M; Foroughi N; Wang Y; Mavros Y; Lampit A; Leung I; Valenzuela MJ, 2016, 'Therapeutically relevant structural and functional mechanisms triggered by physical and cognitive exercise', Molecular Psychiatry, vol. 21, pp. 1633 - 1642, http://dx.doi.org/10.1038/mp.2016.19
    Journal articles | 2015
    Hibar DP; Stein JL; Renteria ME; Arias-Vasquez A; Desrivières S; Jahanshad N; Toro R; Wittfeld K; Abramovic L; Andersson M; Aribisala BS; Armstrong NJ; Bernard M; Bohlken MM; Boks MP; Bralten J; Brown AA; Mallar Chakravarty M; Chen Q; Ching CRK; Cuellar-Partida G; Den Braber A; Giddaluru S; Goldman AL; Grimm O; Guadalupe T; Hass J; Woldehawariat G; Holmes AJ; Hoogman M; Janowitz D; Jia T; Kim S; Klein M; Kraemer B; Lee PH; Olde Loohuis LM; Luciano M; MacAre C; Mather KA; Mattheisen M; Milaneschi Y; Nho K; Papmeyer M; Ramasamy A; Risacher SL; Roiz-Santiañez R; Rose EJ; Salami A; Sämann PG; Schmaal L; Schork AJ; Shin J; Strike LT; Teumer A; Van Donkelaar MMJ; Van Eijk KR; Walters RK; Westlye LT; Whelan CD; Winkler AM; Zwiers MP; Alhusaini S; Athanasiu L; Ehrlich S; Hakobjan MMH; Hartberg CB; Haukvik UK; Heister AJGAM; Hoehn D; Kasperaviciute D; Liewald DCM; Lopez LM; Makkinje RRR; Matarin M; Naber MAM; Reese McKay D; Needham M; Nugent AC; Pütz B; Royle NA; Shen L; Sprooten E; Trabzuni D; Van Der Marel SSL; Van Hulzen KJE; Walton E; Wolf C; Almasy L; Ames D; Arepalli S; Assareh AA; Bastin ME; Brodaty H; Bulayeva KB; Carless MA; Cichon S; Corvin A; Curran JE; Czisch M, 2015, 'Common genetic variants influence human subcortical brain structures', Nature, vol. 520, pp. 224 - 229, http://dx.doi.org/10.1038/nature14101
    Journal articles | 2014
    Batouli SAH; Sachdev PS; Wen W; Trollor JN; Wright MJ; Ames D, 2014, 'Heritability of brain volumes in older adults: The Older Australian Twins Study', Neurobiology of Aging, vol. 35, pp. 937e5 - 937e18, http://dx.doi.org/10.1016/j.neurobiolaging.2013.10.079
    Journal articles | 2014
    Fiatarone Singh MA; Gates N; Saigal N; Wilson GC; Meiklejohn J; Brodaty H; Wen W; Singh N; Baune BT; Suo C; Baker MK; Foroughi N; Wang Y; Sachdev PS; Valenzuela M, 2014, 'The Study of Mental and Resistance Training (SMART) Study-Resistance Training and/or Cognitive Training in Mild Cognitive Impairment: A Randomized, Double-Blind, Double-Sham Controlled Trial', Journal of the American Medical Directors Association, vol. 15, pp. 873 - 880, http://dx.doi.org/10.1016/j.jamda.2014.09.010
    Journal articles | 2014
    Jiang J; Sachdev P; Lipnicki DM; Zhang H; Liu T; Suo C; Zhuang L; Crawford J; Reppermund S; Trollor J; Brodaty H; Wen W; Zhu W, 2014, 'A longitudinal study of brain atrophy over two years in community-dwelling older individuals', NeuroImage, vol. 86, pp. 203 - 211, http://dx.doi.org/10.1016/j.neuroimage.2013.08.022
    Journal articles | 2014
    Thompson PM; Stein JL; Medland SE; Hibar DP; Vasquez AA; Renteria ME; Toro R; Jahanshad N; Schumann G; Franke B; Wright MJ; Martin NG; Agartz I; Alda M; Alhusaini S; Almasy L; Almeida J; Alpert K; Andreasen NC; Andreassen OA; Apostolova LG; Appel K; Armstrong NJ; Aribisala B; Bastin ME; Bauer M; Bearden CE; Bergmann Ø; Binder EB; Blangero J; Bockholt HJ; Bøen E; Bois C; Boomsma DI; Booth T; Bowman IJ; Bralten J; Brouwer RM; Brunner HG; Brohawn DG; Buckner RL; Buitelaar J; Bulayeva K; Bustillo JR; Calhoun VD; Cannon DM; Cantor RM; Carless MA; Caseras X; Cavalleri GL; Chakravarty MM; Chang KD; Ching CRK; Christoforou A; Cichon S; Clark VP; Conrod P; Coppola G; Crespo-Facorro B; Curran JE; Czisch M; Deary IJ; de Geus EJC; den Braber A; Delvecchio G; Depondt C; de Haan L; de Zubicaray GI; Dima D; Dimitrova R; Djurovic S; Dong H; Donohoe G; Duggirala R; Dyer TD; Ehrlich S; Ekman CJ; Elvsåshagen T; Emsell L; Erk S; Espeseth T; Fagerness J; Fears S; Fedko I; Fernández G; Fisher SE; Foroud T; Fox PT; Francks C; Frangou S; Frey EM; Frodl T; Frouin V; Garavan H; Giddaluru S; Glahn DC; Godlewska B; Goldstein RZ; Gollub RL; Grabe HJ, 2014, 'The ENIGMA Consortium: Large-scale collaborative analyses of neuroimaging and genetic data', Brain Imaging and Behavior, vol. 8, pp. 153 - 182, http://dx.doi.org/10.1007/s11682-013-9269-5
    Journal articles | 2013
    He Z; Zhu Q; Wen W; Chen L; Xu H; Li H, 2013, 'Surgical approaches for stage I and II thymoma-associated myasthenia gravis: Feasibility of complete video-assisted thoracoscopic surgery (VATS) thymectomy in comparison with trans-sternal resection', Journal of Biomedical Research, vol. 27, pp. 62 - 70, http://dx.doi.org/10.7555/JBR.27.20120060
    Journal articles | 2013
    Quah-Smith I; Wen W; Chen X; Williams MA; Sachdev PS; Bäumler P, 2013, 'The brain effects of laser acupuncture in depressed individuals: An fMRI investigation', Deutsche Zeitschrift fur Akupunktur, vol. 56, pp. 27 - 28, http://dx.doi.org/10.1016/j.dza.2013.06.008
    Journal articles | 2013
    Sachdev PS; Zhuang L; Braidy N; Wen W, 2013, 'Is Alzheimer’s a disease of the white matter?', Current Opinion in Psychiatry, vol. 26, pp. 244 - 251, http://dx.doi.org/10.1097/YCO.0b013e32835ed6e8
    Journal articles | 2012
    Thillainadesan S; Wen W; Zhuang L; Crawford J; Kochan NA; Reppermund S; Slavin MJ; Trollor JN; Brodaty H; Sachdev PS, 2012, 'Changes in mild cognitive impairment and its subtypes as seen on diffusion tensor imaging', International Psychogeriatrics, vol. 24, pp. 1483 - 1489, http://dx.doi.org/10.1017/S1041610212000270
    Journal articles | 2012
    Wen W; Wu JM; Tu JP, 2012, 'A novel solution combustion synthesis of cobalt oxide nanoparticles as negative-electrode materials for lithium ion batteries', Journal of Alloys and Compounds, vol. 513, pp. 592 - 596, http://dx.doi.org/10.1016/j.jallcom.2011.11.019
    Journal articles | 2012
    Zhuang L; Wen W; Trollor JN; Kochan NA; Reppermund S; Brodaty H; Sachdev PS, 2012, 'Abnormalities of the fornix in mild cognitive impairment are related to episodic memory loss', Journal of Alzheimer's Disease, vol. 29, pp. 629 - 639, http://dx.doi.org/10.3233/jad-2012-111766
    Journal articles | 2011
    Khan AR; Cherbuin N; Wen W; Anstey KJ; Sachdev PS; Beg MF, 2011, 'Optimal weights for local multi-atlas fusion using supervised learning and dynamic information (SuperDyn): Validation on hippocampus segmentation', Neuroimage, vol. 56, pp. 126 - 139, http://dx.doi.org/10.1016/j.neuroimage.2011.01.078
    Journal articles | 2011
    Wen W; Zhu W; He Y; Kochan NA; Reppermund S; Slavin MJ; Brodaty H; Crawford J; Xia A; Sachdev PS, 2011, 'Discrete Neuroanatomical Networks Are Associated with Specific Cognitive Abilities in Old Age', Journal of Neuroscience, vol. 31, pp. 1204 - 1212, http://dx.doi.org/10.1523/JNEUROSCI.4085-10.2011
    Journal articles | 2010
    Li Y; Yao S; Wen W; Xue L; Yan Y, 2010, 'Sol-gel combustion synthesis and visible-light-driven photocatalytic property of perovskite LaNiO3', Journal of Alloys and Compounds, vol. 491, pp. 560 - 564, http://dx.doi.org/10.1016/j.jallcom.2009.10.269
    Journal articles | 2009
    Sachdev PS; Chen X; Brodaty H; Thompson C; Altendorf A; Wen W, 2009, 'The determinants and longitudinal course of post-stroke mild cognitive impairment', Journal of the International Neuropsychological Society, vol. 117, pp. 55 - 62, http://dx.doi.org/10.1017/S1355617709990579
    Journal articles | 2009
    Sachdev PS; Parslow R; Wen W; Anstey KJ; Easteal S, 2009, 'Sex differences in the causes and consequences of white matter hyperintensities', Neurobiology of Aging, vol. 30, pp. 946 - 956, http://dx.doi.org/10.1016/j.neurobiolaging.2007.08.023
    Journal articles | 2009
    Wen W; Sachdev PS; Li JJ; Chen X; Anstey KJ, 2009, 'White matter hyperintensities in the forties: Their prevalence and topography in an epidemiological sample aged 44-48', Human Brain Mapping, vol. 30, pp. 1155 - 1167, http://dx.doi.org/10.1002/hbm.20586
    Journal articles | 2008
    Chua TC; Wen W; Slavin MJ; Sachdev PS, 2008, 'Diffusion tensor imaging in mild cognitive impairment and Alzheimer's disease: a review', Current Opinion in Neurology, vol. 21, pp. 83 - 92, http://dx.doi.org/10.1097/WCO.0b013e3282f4594b
    Journal articles | 2008
    Sachdev PS; Chen X; Wen W; Anstey K, 2008, 'Light to moderate alcohol use is associated with increased cortical gray matter in middle-aged men: A voxel-based morphometric study', Psychiatry Research: Neuroimaging Section, vol. 163, pp. 61 - 69, http://dx.doi.org/10.1016/j.pscychresns.2007.08.009
    Journal articles | 2007
    Sachdev PS; Chen X; Joscelyne A; Wen W; Altendorf A; Brodaty H, 2007, 'Hippocampal size and dementia in stroke patients: the Sydney stroke study', Journal of the Neurological Sciences, vol. 260, pp. 71 - 77, http://dx.doi.org/10.1016/j.jns.2007.04.006
    Journal articles | 2007
    Sachdev PS; Chen X; Joscelyne A; Wen W; Brodaty H, 2007, 'Amygdala in stroke/transient ischemic attack patients and its relationship to cognitive impairment and psychopathology: The Sydney Stroke Study', American Journal of Geriatric Psychiatry, vol. 15, pp. 487 - 496, http://dx.doi.org/10.1097/JGP.0b013e3180581fe6
    Journal articles | 2004
    Jorm AF; Butterworth P; Anstey KJ; Christensen H; Easteal S; Maller J; Mather KA; Turakulov RI; Wen W; Sachdev PS, 2004, 'Memory complaints in a community sample aged 60-64 years: associations with cognitive functioning, psychiatric symptoms, medical conditions, APOE genotype, hippocampus and amygdala volumes, and white-matter hyperintensities', Psychological Medicine, vol. 34, pp. 1495 - 1506, http://dx.doi.org/10.1017/S0033291704003162
    Journal articles | 2004
    Sachdev PS; Brodaty H; Valenzuela MJ; Lorentz L; Looi JC; Wen W; Zagami AS, 2004, 'The neuropsychological profile of vascular cognitive impairment in stroke and TIA patients', Neurology, vol. 62, pp. 912 - 919, http://dx.doi.org/10.1212/01.WNL.0000115108.65264.4B
    Journal articles | 2004
    Wen W; Sachdev PS, 2004, 'The topography of white matter hyperintensities on brain MRI in healthy 60- to 64-year-old individuals', Neuroimage, vol. 22, pp. 144 - 154, http://dx.doi.org/10.1016/j.neuroimage.2003.12.027
    Journal articles | 2003
    Valenzuela MJ; Jones M; Wen W; Rae CD; Graham SL; Schnier R; Sachdev PS, 2003, 'Memory training alters hippocampal neurochemistry in healthy elderly', Neuroreport, vol. 14, pp. 1333 - 1337, http://dx.doi.org/10.1097/00001756-200307180-00010
    Journal articles | 2001
    Sachdev PS; Trollor JN; Walker A; Wen W; Fulham MJ; Smith JS; Matheson JM, 2001, 'Bilateral orbitomedial leucotomy for obsessive-compulsive disorder: a single-case study using positron emission tomography', Australian and New Zealand Journal of Psychiatry, vol. 35, pp. 684 - 690, http://dx.doi.org/10.1046/j.1440-1614.2001.00941.x
  • Working Papers | 2021
    Dong C; Thalamuthu A; Jiang J; Mather K; Brodaty H; Sachdev P; Wen W, 2021, Parental lifespan and polygenic risk score of longevity are associated with white matter hyperintensities, Cold Spring Harbor Laboratory, http://dx.doi.org10.1101/2021.02.02.21251026
  • Preprints | 2021
    Foo H; Thalamuthu A; Jiang J; Koch F; Mather KA; Wen W; Sachdev PS, 2021, Age- and sex-related topological organisation of human brain functional networks and their relationship to cognition, http://dx.doi.org/10.1101/2021.07.25.453293
    Preprints | 2020
    Wierenga L; Doucet G; Dima D; Agartz I; Aghajani M; Akudjedu T; Albajes-Eizagirre A; Alnæs D; Alpert K; Andreassen O; Anticevic A; Asherson P; Banaschewski T; Bargallo N; Baumeister S; Baur-Streubel R; Bertolino A; Bonvino A; Boomsma D; Borgwardt S; Bourque J; den Braber A; Brandeis D; Breier A; Brodaty H; Brouwer R; Buitelaar J; Busatto G; Calhoun V; Canales-Rodríguez E; Cannon D; Caseras X; Castellanos F; Chaim-Avancini T; Ching CRK; Clark V; Conrod P; Conzelmann A; Crivello F; Davey C; Dickie E; Ehrlich S; van ’t Ent D; Fisher S; Fouche J-P; Franke B; Fuentes-Claramonte P; de Geus EJC; Di Giorgio A; Glahn D; Gotlib I; Grabe H; Gruber O; Gruner P; Gur R; Gur R; Gurholt T; de Haan L; Haatveit B; Harrison B; Hartman C; Hatton S; Heslenfeld D; van den Heuvel O; Hickie I; Hoekstra P; Hohmann S; Holmes A; Hoogman M; Hosten N; Howells F; Hulshoff Pol H; Huyser C; Jahanshad N; James A; Jiang J; Jönsson E; Joska J; Kalnin A; Klein M; Koenders L; Kolskår K; Krämer B; Kuntsi J; Lagopoulos J; Lazaro L; Lebedeva I; Lee P; Lochner C; Machielsen MWJ; Maingault S; Martin N; Martínez-Zalacaín I; Mataix-Cols D; Mazoyer B; McDonald B; McDonald C; McIntosh A; McMahon K; McPhilemy G; van der Meer D; Menchón J; Naaijen J; Nyberg L; Oosterlaan J; Paloyelis Y; Pauli P; Pergola G; Pomarol-Clotet E; Portella M; Radua J; Reif A; Richard G; Roffman J; Rosa PGP; Sacchet M; Sachdev P; Salvador R; Sarró S; Satterthwaite T; Saykin A; Serpa M; Sim K; Simmons A; Smoller J; Sommer I; Soriano-Mas C; Stein D; Strike L; Szeszko P; Temmingh H; Thomopoulos S; Tomyshev A; Trollor J; Uhlmann A; Veer I; Veltman D; Voineskos A; Völzke H; Walter H; Wang L; Wang Y; Weber B; Wen W; West J; Westlye L; Whalley H; Williams SCR; Wittfeld K; Wolf D; Wright M; Yoncheva Y; Zanetti M; Ziegler G; de Zubicaray G; Thompson P; Crone E; Frangou S; Tamnes C; Karolinska Schizophrenia Project (KaSP) Consortium , 2020, Greater male than female variability in regional brain structure across the lifespan, http://dx.doi.org/10.1101/2020.02.17.952010
    Conference Posters | 2016
    Perry A; Wen W; Kochan N; Sachdev PS; Breakspear , 2016, 'The independent influences of age and education on functional brain networks and cognition in healthy older adults [Poster]', Vienna, Austria, Vol. 38, pp. 5094 - 5114, presented at Resting State and Brain Connectivity 2016, Vienna, Austria, 21 September 2016 - 23 September 2016, http://dx.doi.org/10.1002/hbm.23717
    Conference Presentations | 2015
    Roberts G; Breakspear M; Wen W; Frankland A; Lau P; Wright A; Perich T; Levy F; Lenroot R; Mitchell P, 2015, 'White Matter Integrity in Young People with Bipolar Disorder are at High Genetic Risk: Tract-Based Spatial Statistics and Probabilistic Tractography', Vol. 77, presented at 70th Annual Scientific Convention and Meeting of the Society-of-Biological-Psychiatry on Stress, Emotion, Neurodevelopment and Psychopathology, CANADA, Toronto, 14 May 2015 - 16 May 2015, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000352207501253&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2007
    Chen X; Sachdev PS; Wen W; Anstey KJ, 2007, 'Risk factors of incidental lacunar infarcts in a community population aged 60-64 years: The path through life study [Abstract]', in Journal of Neurological Sciences, ELSEVIER SCIENCE BV, Budapest, Hungary, Vol. 283, pp. 310 - 310, presented at 5th International Congress on Vascular Dementia, Budapest, Hungary, 08 November 2007 - 11 November 2007, http://dx.doi.org/10.1016/j.jns.2009.02.267

1. Chief Investigator A (CIA): One ARC Discovery project (https://www.arc.gov.au/grants/discovery-program/discovery-projects ); and three NHMRC projects (https://nhmrc.gov.au/funding/find-funding/project-grants ).

2. Chief Investigator (CIx): NHMRC projects.

 

Current Research Themes:

  • Connectome of older brains – both structural and functional descriptions.
  • Longitudinal study of brain in older brains – atrophy, connectivity and functionality.
  • Predicting brain ageing trajectory using imaging, genetics and clinical data.
  • Mapping genetic influences on brain structures and functions with twins design.
  • Functional and structural connectivity and its cognitive relevance.
  • Development of computational algorithms to segment brain lesions – development of a pipeline for automatic lesion detection and computation.
  • Construction of a MRI index for measuring cerebrovascular disease (CVD) burden: a computational approach (together with Dr. Anbu Thalamuthu)

My Research Supervision

Ph.D. and Master's students, ILP and Honours students, and Postdoc fellows.