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Dr Xenia Kaidonis
Conjoint Lecturer

Dr Xenia Kaidonis

Bachelor of Biomedical Science (The University of Adelaide)

Bachelor of Science Honours (The University of Adelaide)

Doctor of Philosophy (The University of Adelaide)

Medicine & Health
School of Clinical Medicine

Dr Kaidonis is a Post-doctoral Scientist at the Victor Chang Cardiac Research Institute. She is dedicated to understanding cardiac biology in two key areas: (i) the role of adrenergic signaling in the heart's response to pathological (eg. myocardial infarction and hypertension) and physiological (eg. exercise and the 'fight or flight' response) stress and (ii) changing biochemical pathways involved in cardiomyocyte maturation. 
Phone
+61 2 9295 8631
E-mail
x.kaidonis@victorchang.edu.au
Location
Victor Chang Cardiac Research Institute Level 5, 405 Liverpool St, Darlinghurst, NSW, 2010
  • Book Chapters | 2023
    Kaidonis X; Mohl MC; Graham RM, 2023, 'α1-Adrenergic receptors', in Primer on the Autonomic Nervous System, Elsevier, pp. 43 - 47, http://dx.doi.org/10.1016/b978-0-323-85492-4.00057-0
    Book Chapters | 2022
    Kaidonis X; Mohl MC; Graham RM, 2022, 'α1-Adrenergic receptors', in Primer on the Autonomic Nervous System, Fourth Edition, pp. 43 - 47, http://dx.doi.org/10.1016/B978-0-323-85492-4.00057-0
  • Journal articles | 2022
    Derrick-Roberts A; Kaidonis X; Jackson MR; Liaw WC; Ding XD; Ong C; Ranieri E; Sharp P; Fletcher J; Byers S, 2022, 'Corrigendum to “Comparative analysis of brain pathology in heparan sulphate storing mucopolysaccharidosis” [Molecular Genetics and Metabolism 131 (2020) pages 197–205](S109671922030175X)(10.1016/j.ymgme.2020.07.006)', Molecular Genetics and Metabolism, 135, pp. 114, http://dx.doi.org/10.1016/j.ymgme.2021.12.011
    Journal articles | 2022
    Yu ZY; Gong H; Kesteven S; Guo Y; Wu J; Li JV; Cheng D; Zhou Z; Iismaa SE; Kaidonis X; Graham RM; Cox CD; Feneley MP; Martinac B, 2022, 'Piezo1 is the cardiac mechanosensor that initiates the cardiomyocyte hypertrophic response to pressure overload in adult mice', Nature Cardiovascular Research, 1, pp. 577 - 591, http://dx.doi.org/10.1038/s44161-022-00082-0
    Journal articles | 2021
    Kaidonis X; Niu W; Chan AY; Kesteven S; Wu J; Iismaa SE; Vatner S; Feneley M; Graham RM, 2021, 'Adaptation to exercise-induced stress is not dependent on cardiomyocyte α1A-adrenergic receptors', Journal of Molecular and Cellular Cardiology, 155, pp. 78 - 87, http://dx.doi.org/10.1016/j.yjmcc.2021.02.010
    Journal articles | 2021
    Yew WP; Djukic ND; Jayaseelan JSP; Kaidonis X; Kremer KL; Choy FC; Woodman RJ; Koblar SA; Sims NR, 2021, 'Delayed Treatment with Human Dental Pulp Stem Cells Accelerates Functional Recovery and Modifies Responses of Peri-Infarct Astrocytes Following Photothrombotic Stroke in Rats', Cell Transplantation, 30, http://dx.doi.org/10.1177/0963689720984437
    Journal articles | 2020
    Derrick-Roberts A; Kaidonis X; Jackson MR; Liaw WC; Ding XD; Ong C; Ranieri E; Sharp P; Fletcher J; Byers S, 2020, 'Comparative analysis of brain pathology in heparan sulphate storing mucopolysaccharidoses', Molecular Genetics and Metabolism, 131, pp. 197 - 205, http://dx.doi.org/10.1016/j.ymgme.2020.07.006
    Journal articles | 2019
    Kaidonis X; Niu W; Chan AY; Kesteven S; Wu J; Iismaa SE; Feneley M; Graham RM, 2019, 'Abstract 579: Involvement of the Alpha 1A-Adrenergic Receptor in the Cardiac Adaptation to Physiological Stress', Circulation Research, 125, http://dx.doi.org/10.1161/res.125.suppl_1.579
    Journal articles | 2018
    Iismaa SE; Kaidonis X; Nicks AM; Bogush N; Kikuchi K; Naqvi N; Harvey RP; Husain A; Graham RM, 2018, 'Comparative regenerative mechanisms across different mammalian tissues', npj Regenerative Medicine, 3, http://dx.doi.org/10.1038/s41536-018-0044-5
    Journal articles | 2017
    Altaii M; Kaidonis X; Koblar S; Cathro P; Richards L, 2017, 'Platelet rich plasma and dentine effect on sheep dental pulp cells regeneration/revitalization ability (in vitro)', Australian Dental Journal, 62, pp. 39 - 46, http://dx.doi.org/10.1111/adj.12426
    Journal articles | 2016
    Kaidonis X; Byers S; Ranieri E; Sharp P; Fletcher J; Derrick-Roberts A, 2016, 'N-butyldeoxynojirimycin treatment restores the innate fear response and improves learning in mucopolysaccharidosis IIIA mice', Molecular Genetics and Metabolism, 118, pp. 100 - 110, http://dx.doi.org/10.1016/j.ymgme.2016.04.002
    Journal articles | 2016
    Nagpal A; Kremer KL; Hamilton-Bruce MA; Kaidonis X; Milton AG; Levi C; Shi S; Carey L; Hillier S; Rose M; Zacest A; Takhar P; Koblar SA, 2016, 'TOOTH (The Open study Of dental pulp stem cell Therapy in Humans): Study protocol for evaluating safety and feasibility of autologous human adult dental pulp stem cell therapy in patients with chronic disability after stroke', International Journal of Stroke, 11, pp. 575 - 585, http://dx.doi.org/10.1177/1747493016641111
    Journal articles | 2016
    Pan W; Kremer KL; Kaidonis X; Ludlow VE; Rogers ML; Xie J; Proud CG; Koblar SA, 2016, 'Characterization of p75 neurotrophin receptor expression in human dental pulp stem cells', International Journal of Developmental Neuroscience, 53, pp. 90 - 98, http://dx.doi.org/10.1016/j.ijdevneu.2016.07.007
    Journal articles | 2014
    Derrick-Roberts ALK; Pyragius CE; Kaidonis XM; Jackson MR; Anson DS; Byers S, 2014, 'Lentiviral-mediated gene therapy results in sustained expression of β-Glucuronidase for up to 12 Months in the Gusmps/mpsand up to 18 Months in the Gustm(L175F)Slymouse models of mucopolysaccharidosis type VII', Human Gene Therapy, 25, pp. 798 - 810, http://dx.doi.org/10.1089/hum.2013.141
    Journal articles | 2010
    Kaidonis X; Liaw WC; Roberts AD; Ly M; Anson D; Byers S, 2010, 'Gene silencing of EXTL2 and EXTL3 as a substrate deprivation therapy for heparan sulphate storing mucopolysaccharidoses', European Journal of Human Genetics, 18, pp. 194 - 199, http://dx.doi.org/10.1038/ejhg.2009.143
  • Conference Abstracts | 2022
    Yu Z-Y; Gong H; Kesteven S; Guo Y; Wu J; Li J; Iismaa S; Kaidonis X; Graham RM; Cox CD; Feneley MP; Martinac B, 2022, 'Piezo1 and TRPM4 work in tandem to initiate cardiac hypertrophic signalling in response to pressure overload', in BIOPHYSICAL JOURNAL, CELL PRESS, Vol. 121, pp. 493A - 493A, http://dx.doi.org/10.1016/j.bpj.2021.11.321
    Conference Abstracts | 2019
    Kaidonis X; Niu W; Chan AY; Kesteven S; Wu J; Iismaa SE; Feneley M; Graham RM, 2019, 'Involvement of the Alpha 1A-Adrenergic Receptor in the Cardiac Adaptation to Physiological Stress', in CIRCULATION RESEARCH, LIPPINCOTT WILLIAMS & WILKINS, MA, Boston, Vol. 125, presented at 14th Annual American-Heart-Association's Basic Cardiovascular Sciences (BCVS) Scientific Sessions - Integrative Approaches to Complex Cardiovascular Diseases, MA, Boston, 29 July 2019 - 01 August 2019, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000511467800348&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Elucidating the cardioprotective role of the α1A-adrenergic receptor

The α1A-adrenergic receptor (α1A-AR) protects cardiomyocytes from catacholamine-mediated damage in the failing heart. However, it is not known whether α1A-ARs also play a role in cardioprotection when the heart is challenged with a physiological stress, such as occurs during the ‘fight or flight’ response. This area of research is important to understanding how the heart has evolved to facilitate the survival of the fittest.

 

Understanding metabolomic changes during cardiac development

The ability of the heart to repair after injury is lost as the heart grows and matures. Our investigation into developmental changes to cardiac metabolites may provide insights into pathways that can be targeted so that regeneration can be enhanced after cardiac injury in adults. We have used mass spectrometry at key developmental time points to identify these metabolic changes.