Dr Xiaotao   Jiang
Postdoctoral Fellow

Dr Xiaotao Jiang

Bachelor of Engineering (Bioinformatics)

Doctor of Philosophy (Water and Environmental Microbiology)

medicine-health
St. George Clin Sch- Operating

My Current Research Interests:

1. Microbiome in health and diseases

2. Antimicrobial resistance 

3. Virome

4. Microbiome bioinformatics 

Dr. Jiang leads the bioinformatics unit at the MRC and has been involved in an extensive number of projects for the human microbiome and diseases including liver cancer, colon cancer, IBD, schizophrenia et. al. He is interested in developing bioinformatics algorithms and software to analyze next/third generation sequencing data for multi-omics data (metagenomics, metatranscriptomics, and metabolomics). Another interest of Dr. Jiang is antimicrobial resistance. He is interested in developing methods to combat the ever-increasing issue of antimicrobial resistance from the medical application. 

My Background:

Dr Jiang completed his PhD in The University of Hong Kong, Hong Kong. In his PhD study, he applied large-scale metagenomics sequencing to understand the activated sludge microbial ecology in a spatial and temporal dimension.  He developed ARGs-OAP to obtain the quantitative profiling of resistome for multiple shotgun metagenomics data, which is widely used in the AMR area.  

Publications

  • Journal articles | 2021
    Dr Xiaotao Jiang
    Wang Y; Qin W; Jiang X; Ju F; Mao Y; Zhang A; Stahl DA; Zhang T, 2021, 'Seasonal prevalence of ammonia-oxidizing archaea in a full-scale municipal wastewater treatment plant treating saline wastewater revealed by a 6-year time-series analysis', Environmental Science and Technology, vol. 55, pp. 2662 - 2673, http://dx.doi.org/10.1021/acs.est.0c07703
    Journal articles | 2021
    Dr Xiaotao Jiang
    Behary J; Amorim N; Jiang XT; Raposo A; Gong L; McGovern E; Ibrahim R; Chu F; Stephens C; Jebeili H; Fragomeli V; Koay YC; Jackson M; O’Sullivan J; Weltman M; McCaughan G; El-Omar E; Zekry A, 2021, 'Gut microbiota impact on the peripheral immune response in non-alcoholic fatty liver disease related hepatocellular carcinoma', Nature Communications, vol. 12, pp. 187, http://dx.doi.org/10.1038/s41467-020-20422-7
    Journal articles | 2019
    Dr Xiaotao Jiang
    Liu J; Li B; Wang Y; Zhang G; Jiang X; Li X, 2019, 'Passage and community changes of filterable bacteria during microfiltration of a surface water supply', Environment International, vol. 131, pp. 104998 - 104998, http://dx.doi.org/10.1016/j.envint.2019.104998
    Journal articles | 2019
    Dr Xiaotao Jiang
    Ng C; Tan B; Jiang XT; Gu X; Chen H; Schmitz BW; Haller L; Charles FR; Zhang T; Gin K, 2019, 'Metagenomic and resistome analysis of a full-scale municipal wastewater treatment plant in Singapore containing membrane bioreactors', Frontiers in Microbiology, vol. 10, pp. 172, http://dx.doi.org/10.3389/fmicb.2019.00172
    Journal articles | 2018
    Dr Xiaotao Jiang
    Jiang XT; Ye L; Ju F; Li B; Ma LP; Zhang T, 2018, 'Temporal dynamics of activated sludge bacterial communities in two diversity variant full-scale sewage treatment plants', Applied Microbiology and Biotechnology, vol. 102, pp. 9379 - 9388, http://dx.doi.org/10.1007/s00253-018-9287-8
    Journal articles | 2018
    Dr Xiaotao Jiang
    Jiang X-T; Ye L; Ju F; Wang Y-L; Zhang T, 2018, 'Toward an Intensive Longitudinal Understanding of Activated Sludge Bacterial Assembly and Dynamics', Environmental Science & Technology, vol. 52, pp. 8224 - 8232
    Journal articles | 2018
    Dr Xiaotao Jiang
    Yin X; Jiang XT; Chai B; Li L; Yang Y; Cole JR; Tiedje JM; Zhang T, 2018, 'ARGs-OAP v2.0 with an expanded SARG database and Hidden Markov Models for enhancement characterization and quantification of antibiotic resistance genes in environmental metagenomes', Bioinformatics, vol. 34, pp. 2263 - 2270, http://dx.doi.org/10.1093/bioinformatics/bty053
    Journal articles | 2018
    Dr Xiaotao Jiang
    Liu T; Zhang AN; Wang J; Liu S; Jiang X; Dang C; Ma T; Liu S; Chen Q; Xie S; others , 2018, 'Integrated biogeography of planktonic and sedimentary bacterial communities in the Yangtze River', Microbiome, vol. 6, pp. 16 - 16, http://dx.doi.org/10.1186/s40168-017-0388-x
    Journal articles | 2018
    Dr Xiaotao Jiang
    Feng J; Li B; Jiang X; Yang Y; Wells GF; Zhang T; Li X, 2018, 'Antibiotic resistome in a large-scale healthy human gut microbiota deciphered by metagenomic and network analyses', Environmental microbiology, vol. 20, pp. 355 - 368, http://dx.doi.org/10.1111/1462-2920.14009
    Journal articles | 2018
    Dr Xiaotao Jiang
    Xiong W; Wang Y; Sun Y; Ma L; Zeng Q; Jiang X; Li A; Zeng Z; Zhang T, 2018, 'Antibiotic-mediated changes in the fecal microbiome of broiler chickens define the incidence of antibiotic resistance genes', Microbiome, vol. 6, pp. 34 - 34, http://dx.doi.org/10.1186/s40168-018-0419-2
    Journal articles | 2018
    Dr Xiaotao Jiang
    Zhang G; Li B; Liu J; Luan M; Yue L; Jiang XT; Yu K; Guan Y, 2018, 'The bacterial community significantly promotes cast iron corrosion in reclaimed wastewater distribution systems', Microbiome, vol. 6, http://dx.doi.org/10.1186/s40168-018-0610-5
    Journal articles | 2018
    Dr Xiaotao Jiang
    Wang Y; Jiang X-T; Liu L; Li B; Zhang T, 2018, 'High-Resolution Temporal and Spatial Patterns of Virome in Wastewater Treatment Systems', Environmental science & technology
    Journal articles | 2017
    Dr Xiaotao Jiang
    Yuan K; Xiao S; Jiang X; Yang L; Chen B; Luan T; Lin L; Tam NFY, 2017, 'Effects of endocrine disrupting chemicals (EDCs) on bacterial communities in mangrove sediments', Marine Pollution Bulletin, vol. 122, pp. 122 - 128, http://dx.doi.org/10.1016/j.marpolbul.2017.06.035
    Journal articles | 2017
    Dr Xiaotao Jiang
    Li AD; Ma L; Jiang XT; Zhang T, 2017, 'Cultivation-dependent and high-throughput sequencing approaches studying the co-occurrence of antibiotic resistance genes in municipal sewage system', Applied Microbiology and Biotechnology, vol. 101, pp. 8197 - 8207, http://dx.doi.org/10.1007/s00253-017-8573-1
    Journal articles | 2017
    Dr Xiaotao Jiang
    Xia Y; Li AD; Deng Y; Jiang XT; Li LG; Zhang T, 2017, 'MinION Nanopore sequencing enables correlation between resistome phenotype and genotype of coliform bacteria in municipal sewage', Frontiers in Microbiology, vol. 8, http://dx.doi.org/10.3389/fmicb.2017.02105
    Journal articles | 2017
    Dr Xiaotao Jiang
    Ma L; Li B; Jiang X-T; Wang Y-L; Xia Y; Li A-D; Zhang T, 2017, 'Catalogue of antibiotic resistome and host-tracking in drinking water deciphered by a large scale survey', Microbiome, vol. 5, pp. 154 - 154, http://dx.doi.org/10.1186/s40168-017-0369-0
    Journal articles | 2017
    Dr Xiaotao Jiang
    Wang Y; Ma L; Mao Y; Jiang X; Xia Y; Yu K; Li B; Zhang T, 2017, 'Comammox in drinking water systems', Water Research, vol. 116, pp. 332 - 341, http://dx.doi.org/10.1016/j.watres.2017.03.042
    Journal articles | 2016
    Dr Xiaotao Jiang
    Yang Y; Jiang X; Chai B; Ma L; Li B; Zhang A; Cole JR; Tiedje JM; Zhang T, 2016, 'ARGs-OAP: Online analysis pipeline for antibiotic resistance genes detection from metagenomic data using an integrated structured ARG-database', Bioinformatics, vol. 32, pp. 2346 - 2351, http://dx.doi.org/10.1093/bioinformatics/btw136
    Journal articles | 2016
    Dr Xiaotao Jiang
    Mao Y; Wang Z; Li L; Jiang X; Zhang X; Ren H; Zhang T, 2016, 'Exploring the shift in structure and function of microbial communities performing biological phosphorus removal', PLoS ONE, vol. 11, pp. e0161506, http://dx.doi.org/10.1371/journal.pone.0161506
    Journal articles | 2016
    Dr Xiaotao Jiang
    Jiang XT; Guo F; Zhang T, 2016, 'Population dynamics of bulking and foaming bacteria in a full-scale wastewater treatment plant over five years', Scientific Reports, vol. 6, http://dx.doi.org/10.1038/srep24180
    Journal articles | 2015
    Dr Xiaotao Jiang
    He Y; Caporaso JG; Jiang X-T; Sheng H-F; Huse SM; Rideout JR; Edgar RC; Kopylova E; Walters WA; Knight R; Zhou H-W, 2015, 'Stability of operational taxonomic units: an important but neglected property for analyzing microbial diversity', MICROBIOME, vol. 3, http://dx.doi.org/10.1186/s40168-015-0081-x
    Journal articles | 2014
    Dr Xiaotao Jiang
    Yang Y; Jiang XT; Zhang T, 2014, 'Evaluation of a hybrid approach using UBLAST and BLASTX for metagenomic sequences annotation of specific functional genes', PLoS ONE, vol. 9, pp. e110947, http://dx.doi.org/10.1371/journal.pone.0110947
    Journal articles | 2013
    Dr Xiaotao Jiang
    He Y; Zhou BJ; Deng GH; Jiang XT; Zhang H; Zhou HW, 2013, 'Comparison of microbial diversity determined with the same variable tag sequence extracted from two different PCR amplicons', BMC Microbiology, vol. 13, http://dx.doi.org/10.1186/1471-2180-13-208
    Journal articles | 2013
    Dr Xiaotao Jiang
    Jiang XT; Peng X; Deng GH; Sheng HF; Wang Y; Zhou HW; Tam NFY, 2013, 'Illumina Sequencing of 16S rRNA Tag Revealed Spatial Variations of Bacterial Communities in a Mangrove Wetland', Microbial Ecology, vol. 66, pp. 96 - 104, http://dx.doi.org/10.1007/s00248-013-0238-8
    Journal articles | 2012
    Dr Xiaotao Jiang
    Jiang XT; Zhang H; Sheng HF; Wang Y; He Y; Zou F; Zhou HW, 2012, 'Two-stage clustering (TSC): A pipeline for selecting operational taxonomic units for the high-throughput sequencing of PCR amplicons', PLoS ONE, vol. 7, pp. e30230, http://dx.doi.org/10.1371/journal.pone.0030230
    Journal articles | 2011
    Dr Xiaotao Jiang
    Zhou HW; Li DF; Tam NFY; Jiang XT; Zhang H; Sheng HF; Qin J; Liu X; Zou F, 2011, 'BIPES, a cost-effective high-throughput method for assessing microbial diversity', ISME Journal, vol. 5, pp. 741 - 749, http://dx.doi.org/10.1038/ismej.2010.160
    Journal articles | 2010
    Dr Xiaotao Jiang
    Wu JY; Jiang XT; Jiang YX; Lu SY; Zou F; Zhou HW, 2010, 'Effects of polymerase, template dilution and cycle number on PCR based 16 S rRNA diversity analysis using the deep sequencing method', BMC Microbiology, vol. 10, http://dx.doi.org/10.1186/1471-2180-10-255

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