Dr Xiaoying Chen

Conjoint Lecturer
Medicine & Health
George Institute for Global Health

Dr Xiaoying Chen is a Heart Foundation Postdoctoral Fellow and a Senior Research Fellow in the Global Brain Health Program at the George Institute for Global Health. She has over 18 years’ experience in international multicenter clinical trials and 14 years in designing and conducting large international clinical trials.  She has led and been pivotal to the success of multiple international randomised controlled trials which have had significant impact on guidelines, and decision-making in clinical practice.  Her research program focuses on treatment in acute stroke care and stroke recovery by designing and implementing innovative large international clinical trials, developing new tools and measures to support stroke care, especially for remote and underserved population.

Phone
+61-2-8052 4549
  • Journal articles | 2024
    Billot L; Chen C; Song L; Lin Y; Liu F; Chen X; Arima H; Bath PM; Ford GA; Robinson TG; Sandset EC; Saver JL; Sprigg N; Van Der Worp HB; Yang J; Li G; Anderson CS, 2024, 'Statistical Analysis Plan for the INTEnsive Ambulance-Delivered Blood Pressure Reduction in Hyper-ACute Stroke Trial', Cerebrovascular Diseases, http://dx.doi.org/10.1159/000539503
    Journal articles | 2024
    Chen C; Ren X; Zhao Y; Ouyang M; Li Mbiostat Q; Wang X; Li Y; You S; Wang Y; Robinson TG; Lindley R; Arima H; Chalmers J; Li G; Chen X; Anderson CS; Song L, 2024, 'Intensive Blood Pressure Lowering and Renal Function in Ischemic Stroke Patients: Secondary Analysis of the ENCHANTED Trial', Cerebrovascular Diseases, http://dx.doi.org/10.1159/000536275
    Journal articles | 2024
    Han Q; You S; Maeda T; Wang Y; Ouyang M; Li Q; Song L; Zhao Y; Ren X; Chen C; Delcourt C; Zhou Z; Cao Y; Liu CF; Zheng D; Arima H; Robinson TG; Chen X; Lindley RI; Chalmers J; Anderson CS; Wang X, 2024, 'Predictors of Early versus Delayed Neurological Deterioration after Thrombolysis for Ischemic Stroke', Cerebrovascular Diseases, http://dx.doi.org/10.1159/000539322
    Journal articles | 2024
    Howard L; Abdelnour C; Abner EL; Allegri RF; Dodge HH; Gauthier S; Hoyos CM; Jicha GA; Kehoe PG; Mummery CJ; Ogunniyi A; Scarmeas N; Chen X; Titiner JR; Weber CR; Peters R, 2024, 'Decentralized clinical trials for medications to reduce the risk of dementia: Consensus report and guidance', Alzheimer's and Dementia, 20, pp. 4625 - 4634, http://dx.doi.org/10.1002/alz.13891
    Journal articles | 2024
    Maeda T; Woodward M; Jun M; Sakamoto Y; Chen X; Matsushita K; Mancia G; Arima H; Anderson CS; Chalmers J; Harris K, 2024, 'Risk of recurrent stroke and dementia following acute stroke by changes in kidney function: results from the Perindopril Protection Against Recurrent Stroke Study', Journal of Hypertension, 42, pp. 1313 - 1321, http://dx.doi.org/10.1097/HJH.0000000000003711
    Journal articles | 2024
    You S; Zheng D; Yoshimura S; Ouyang M; Han Q; Wang X; Cao Y; Delcourt C; Song L; Arima H; Chen X; Liu CF; Lindley RI; Robinson T; Anderson CS; Chalmers J, 2024, 'Optimum Baseline Clinical Severity Scale Cut Points for Prognosticating Intracerebral Hemorrhage: INTERACT Studies', Stroke, 55, pp. 139 - 145, http://dx.doi.org/10.1161/STROKEAHA.123.044538
    Journal articles | 2023
    Banzrai C; Bosookhuu O; Yadamsuren E; Dambasuren B; Turbat S; Erdenedalai T; Myadagsuren M; Munkhtur U; Baatar K; Boldbayar P; Avirmed T; Badrakh B; Ouyang M; Chen X; Wang X; Anderson CS, 2023, 'Incidence and outcomes for stroke in Ulaanbaatar, Mongolia, during 2019–21: a prospective population-based study', The Lancet Global Health, 11, pp. e942 - e952, http://dx.doi.org/10.1016/S2214-109X(23)00130-4
    Journal articles | 2023
    Billot L; Song L; Hu X; Ma L; Ouyang M; Chen X; You C; Anderson CS, 2023, 'Statistical Analysis Plan for the INTEnsive Care Bundle with Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial: A Stepped-Wedge Cluster Randomized Controlled Trial', Cerebrovascular Diseases, 52, pp. 251 - 254, http://dx.doi.org/10.1159/000526384
    Journal articles | 2023
    Chen C; Lin Y; Liu F; Chen X; Billot L; Li Q; Guo Y; Liu H; Si L; Ouyang M; Zhang C; Arima H; Bath PM; Ford GA; Robinson T; Sandset EC; Saver JL; Sprigg N; van der Worp HB; Liu G; Song L; Yang J; Li G; Anderson CS, 2023, 'Update on the INTEnsive ambulance-delivered blood pressure Reduction in hyper-ACute stroke Trial (INTERACT4): progress and baseline features in 2053 participants', Trials, 24, http://dx.doi.org/10.1186/s13063-023-07861-5
    Journal articles | 2023
    Chen C; Ouyang M; Ong S; Zhang L; Zhang G; Delcourt C; Mair G; Liu L; Billot L; Li Q; Chen X; Parsons M; Broderick JP; Demchuk AM; Bath PM; Donnan GA; Levi C; Chalmers J; Lindley RI; Martins SO; Pontes-Neto OM; Venturelli PM; Olavarría V; Lavados P; Robinson TG; Wardlaw JM; Li G; Wang X; Song L; Anderson CS; Munoz Venturelli P, 2023, 'Effects of intensive blood pressure lowering on cerebral ischaemia in thrombolysed patients: insights from the ENCHANTED trial', eClinicalMedicine, 57, pp. 101849, http://dx.doi.org/10.1016/j.eclinm.2023.101849
    Journal articles | 2023
    Ma L; Hu X; Song L; Chen X; Ouyang M; Billot L; Li Q; Malavera A; Li X; Muñoz-Venturelli P; de Silva A; Thang NH; Wahab KW; Pandian JD; Wasay M; Pontes-Neto OM; Abanto C; Arauz A; Shi H; Tang G; Zhu S; She X; Liu L; Sakamoto Y; You S; Han Q; Crutzen B; Cheung E; Li Y; Wang X; Chen C; Liu F; Zhao Y; Li H; Liu Y; Jiang Y; Chen L; Wu B; Liu M; Xu J; You C; Anderson CS; Robinson T; Miranda JJ; Parry-Jones A; Sprigg N; Durrans S; Harris C; Bamford A; Smith O; Herbert R; Chen C; Whiteley W; Hu R; Mysore J; Zhang Y; Jan S; Liu H; Sun L; Chu H; Anjum A; Gonzalez Mc Cawley F; Del Rio A; Rimoli B; Cerantola R; Jeevarajah T; Kannangara M; Joseph A; Nanayakkara C; Zhang C; Yang Z; Li B; Meng Z; Ning Y; Dong L; Armenis M; Lim J; Monaghan H; Luo R; Cheng G; Dong Y; Liu Z; Wang S; Zhang Y; Cheng J; Shi H; Li W; Mou L; Yi P; Chen X; Weerawardena S; Ellawala P; Ranasinghe E; Rodrigo C; Adeniyi S; Khanna M; Muñoz Venturelli P; González F; Urrutia Goldsack F, 2023, 'The third Intensive Care Bundle with Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT3): an international, stepped wedge cluster randomised controlled trial', The Lancet, 402, pp. 27 - 40, http://dx.doi.org/10.1016/S0140-6736(23)00806-1
    Journal articles | 2023
    Si L; Chen X; Ouyang M; Wang X; Chen G; Cao YJ; Wu G; Zhang J; Zhang J; Liu YK; Zhang S; Song L; Delcourt C; Arima H; Wang L; Lung T; Chen M; Anderson CS; Jan S, 2023, 'Cost-Effectiveness of Low-Dose Compared to Standard-Dose Alteplase for Acute Ischemic Stroke in China: A Within-Trial Economic Evaluation of the ENCHANTED Study', Cerebrovascular Diseases, 52, pp. 145 - 152, http://dx.doi.org/10.1159/000525869
    Journal articles | 2023
    Song L; Chen X, 2023, 'Trials in intracerebral haemorrhage: a path to success?', The Lancet Neurology, 22, pp. 542 - 543, http://dx.doi.org/10.1016/S1474-4422(23)00201-6
    Journal articles | 2023
    Wang X; You S; Zhou Z; Delcourt C; Wardlaw J; Mair G; Robinson T; Chen X; Yoshimura S; Torii-Yoshimura T; Carcel C; Malavera A; Anderson C; Lindley RI, 2023, 'Baseline brain imaging signs in patients with ischaemic stroke by the presence of atrial fibrillation: the ENCHANTED trial', Journal of Neurology, 270, pp. 2567 - 2575, http://dx.doi.org/10.1007/s00415-023-11580-x
    Journal articles | 2023
    Zhao Y; Hua X; Ren X; Ouyang M; Chen C; Li Y; Yin X; Song P; Chen X; Wu S; Song L; Anderson CS, 2023, 'Increasing burden of stroke in China: A systematic review and meta-analysis of prevalence, incidence, mortality, and case fatality', International Journal of Stroke, 18, pp. 259 - 267, http://dx.doi.org/10.1177/17474930221135983
    Journal articles | 2022
    Chen X; Anderson CS, 2022, 'Revisiting the Adiposity Paradox for the Risk of Stroke Subtypes', JAMA Network Open, 5, pp. E2246621, http://dx.doi.org/10.1001/jamanetworkopen.2022.46621
    Journal articles | 2022
    Ouyang M; Anderson CS; Song L; Jan S; Sun L; Cheng G; Chu H; Hu X; Ma L; Chen X; You C; Liu H, 2022, 'Implementing a Goal-Directed Care Bundle after Acute Intracerebral Haemorrhage: Process Evaluation for the Third INTEnsive Care Bundle with Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial Study in China', Cerebrovascular Diseases, 51, pp. 373 - 383, http://dx.doi.org/10.1159/000520669
    Journal articles | 2022
    Ouyang M; Anderson CS; Song L; Malavera A; Jan S; Cheng G; Chu H; Hu X; Ma L; Chen X; You C; Liu H, 2022, 'Process Evaluation of an Implementation Trial: Design, Rationale, and Early Lessons Learnt From an International Cluster Clinical Trial in Intracerebral Hemorrhage', Frontiers in Medicine, 9, http://dx.doi.org/10.3389/fmed.2022.813749
    Journal articles | 2022
    Song L; Yang P; Zhang Y; Zhang X; Chen X; Li Y; Shen H; Zhang L; Li Z; Zhang Y; Xing P; Zhang P; Zhou Y; Ren X; Billot L; Wang X; Parsons MW; Butcher K; Campbell B; Robinson T; Goyal M; Dippel D; Roos Y; Majoie C; Liu J; Anderson CS, 2022, 'The second randomized controlled ENhanced Control of Hypertension ANd Thrombectomy strokE stuDy (ENCHANTED2): Protocol and progress', International Journal of Stroke, 18, http://dx.doi.org/10.1177/17474930221120345
    Journal articles | 2022
    Wang X; Minhas JS; Moullaali TJ; Luca Di Tanna G; Lindley RI; Chen X; Arima H; Chen G; Delcourt C; Bath PM; Broderick JP; Demchuk AM; Donnan GA; Durham AC; Lavados PM; Lee TH; Levi C; Martins SO; Olavarria VV; Pandian JD; Parsons MW; Pontes-Neto OM; Ricci S; Sato S; Sharma VK; Silva F; Thang NH; Wang JG; Woodward M; Chalmers J; Song L; Anderson CS; Robinson TG; Di Tanna GL, 2022, 'Associations of Early Systolic Blood Pressure Control and Outcome after Thrombolysis-Eligible Acute Ischemic Stroke: Results from the ENCHANTED Study', Stroke, 29, pp. 779 - 787, http://dx.doi.org/10.1161/STROKEAHA.121.034580
    Journal articles | 2022
    Yang P; Song L; Zhang Y; Zhang X; Chen X; Li Y; Sun L; Wan Y; Billot L; Li Q; Ren X; Shen H; Zhang L; Li Z; Xing P; Zhang Y; Zhang P; Hua W; Shen F; Zhou Y; Tian B; Chen W; Han H; Zhang L; Xu C; Li T; Peng Y; Yue X; Chen S; Wen C; Wan S; Yin C; Wei M; Shu H; Nan G; Liu S; Liu W; Cai Y; Sui Y; Chen M; Zhou Y; Zuo Q; Dai D; Zhao R; Huang Q; Xu Y; Deng B; Wu T; Lu J; Wang X; Parsons MW; Butcher K; Campbell B; Robinson TG; Goyal M; Dippel D; Roos Y; Majoie C; Wang L; Wang Y; Liu J; Anderson CS, 2022, 'Intensive blood pressure control after endovascular thrombectomy for acute ischaemic stroke (ENCHANTED2/MT): a multicentre, open-label, blinded-endpoint, randomised controlled trial', The Lancet, 400, pp. 1585 - 1596, http://dx.doi.org/10.1016/S0140-6736(22)01882-7
    Journal articles | 2022
    Zhao WY; Zhang L; Wan Y; Chen X; Jin Y; Zhang L; Sum G; Katar A; Song L; Anderson CS, 2022, 'The association between functional status and physical pain with depressive symptoms after a stroke event: A cross-sectional analysis of the China Health and Retirement Longitudinal Study 2018', Frontiers in Psychiatry, 13, http://dx.doi.org/10.3389/fpsyt.2022.927856
    Journal articles | 2022
    Zhou Z; Xia C; Mair G; Delcourt C; Yoshimura S; Liu X; Chen Z; Malavera A; Carcel C; Chen X; Wang X; Al-Shahi Salman R; Robinson TG; Lindley RI; Chalmers J; Wardlaw JM; Parsons MW; Demchuk AM; Anderson CS, 2022, 'Thrombolysis outcomes according to arterial characteristics of acute ischemic stroke by alteplase dose and blood pressure target', International Journal of Stroke, 17, pp. 566 - 575, http://dx.doi.org/10.1177/17474930211025436
    Journal articles | 2021
    Chen C; Wang X; Chen X; Ouyang M; Sun L; Arima H; Robinson T; Lindley RI; Chalmers J; Li G; Song L; Anderson CS, 2021, 'Disparities between Asian and Non-Asian Thrombolyzed Acute Ischemic Stroke Patients in the Enhanced Control of Hypertension and Thrombolysis Stroke Trial', Cerebrovascular Diseases, 50, pp. 560 - 566, http://dx.doi.org/10.1159/000516487
    Journal articles | 2021
    Chen X; Li J; Anderson CS; Lindley RI; Hackett ML; Robinson T; Lavados PM; Wang X; Arima H; Chalmers J; Delcourt C, 2021, 'Validation of the simplified modified Rankin scale for stroke trials: Experience from the ENCHANTED alteplase-dose arm', International Journal of Stroke, 16, pp. 222 - 228, http://dx.doi.org/10.1177/1747493019897858
    Journal articles | 2021
    Song L; Chen C; Chen X; Guo Y; Liu F; Lin Y; Billot L; Li Q; Liu H; Si L; Ouyang M; Arima H; Bath PM; Ford GA; Robinson TG; Sandset EC; Saver JL; Sprigg N; van der Worp HB; Zhang C; Yang J; Li G; Anderson CS; Anderson CS; Li G; Yang J; Song L; Worp B; Liu Z; Dawson J; Wong L; Peng B; Li Q; Ning Y; Song L; Chen X; Yang Z; Yu W; Li G; Chen C; Liu F; Yang J; Guo Y; Lin Y; Hu R; Cheng H; Ma W; Liao K; Zhang C; Jin H; Li G; Yang J; Xu P; Wu X; Wang F; Wu L; Wang C; Peng Y; Zhao X; Xu X; Liu X; Song X; Li Z; Zhang H; Yu D; Wang Y; Tang X; Liu H; Cao X; Liu Y; Duan Y; Liu H; Li C; Huang J; Li H; Fan C; Tang Y; Ji Y; Li G; Huang Y; Chen G; Wang J, 2021, 'INTEnsive ambulance-delivered blood pressure Reduction in hyper-ACute stroke Trial (INTERACT4): study protocol for a randomized controlled trial', Trials, 22, pp. 1 - 14, http://dx.doi.org/10.1186/s13063-021-05860-y
    Journal articles | 2021
    Song L; Hu X; Ma L; Chen X; Ouyang M; Billot L; Li Q; Muñoz-Venturelli P; Abanto C; Pontes-Neto OM; Antonio A; Wasay M; Silva AD; Thang NH; Pandian JD; Wahab KW; You C; Anderson CS; Munoz Venturelli P, 2021, 'INTEnsive care bundle with blood pressure reduction in acute cerebral hemorrhage trial (INTERACT3): study protocol for a pragmatic stepped-wedge cluster-randomized controlled trial', Trials, 22, pp. 1 - 14, http://dx.doi.org/10.1186/s13063-021-05881-7
    Journal articles | 2021
    Song L; Wang X; Ouyang M; Sun L; Chen X; Arima H; Sandset EC; Delcourt C; Wang J; Chen G; Robinson T; Lindley RI; Chalmers J; Anderson CS, 2021, 'Associations of an Abnormal Physiological Score With Outcomes in Acute Intracerebral Hemorrhage: INTERACT2 Study', Stroke, 52, pp. 722 - 725, http://dx.doi.org/10.1161/STROKEAHA.120.030435
    Journal articles | 2021
    Xia C; Wang X; Lindley RI; Delcourt C; Chen X; Zhou Z; Guo R; Carcel C; Malavera A; Calic Z; Mair G; Wardlaw JM; Robinson TG; Anderson CS, 2021, 'Early decompressive hemicraniectomy in thrombolyzed acute ischemic stroke patients from the international ENCHANTED trial', Scientific Reports, 11, pp. 16495, http://dx.doi.org/10.1038/s41598-021-96087-z
    Journal articles | 2021
    Zhou Z; Delcourt C; Xia C; Yoshimura S; Carcel C; Torii-Yoshimura T; You S; Malavera A; Chen X; Hackett M; Woodward M; Chalmers J; Xu J; Robinson TG; Parsons MW; Demchuk AM; Lindley R; Mair G; Wardlaw JM; Anderson CS, 2021, 'Low Dose versus Standard Dose Alteplase in Acute Lacunar Ischemic Stroke.', STROKE, 52, http://dx.doi.org/10.1161/str.52.suppl_1.MP3
    Journal articles | 2021
    Zhou Z; Delcourt C; Xia C; Yoshimura S; Carcel C; Torii-Yoshimura T; You S; Malavera A; Chen X; Hackett ML; Woodward M; Chalmers J; Xu J; Robinson TG; Parsons MW; Demchuk AM; Lindley RI; Mair G; Wardlaw JM; Anderson CS, 2021, 'Low-Dose vs Standard-Dose Alteplase in Acute Lacunar Ischemic Stroke: The ENCHANTED Trial', Neurology, 96, pp. E1512 - E1526, http://dx.doi.org/10.1212/WNL.0000000000011598
    Journal articles | 2021
    Zhou Z; Xia C; Carcel C; Yoshimura S; Wang X; Delcourt C; Malavera A; Chen X; Mair G; Woodward M; Chalmers J; Demchuk AM; Lindley RI; Robinson TG; Parsons MW; Wardlaw JM; Anderson CS, 2021, 'Intensive versus guideline-recommended blood pressure reduction in acute lacunar stroke with intravenous thrombolysis therapy: The ENCHANTED trial', European Journal of Neurology, 28, pp. 783 - 793, http://dx.doi.org/10.1111/ene.14598
    Journal articles | 2020
    Chen X; Delcourt C; Sun L; Zhou Z; Yoshimura S; You S; Malavera A; Torii-Yoshimura T; Carcel C; Arima H; Hackett ML; Robinson T; Song L; Wang X; Lindley RI; Chalmers J; Anderson CS, 2020, 'Brain Imaging Signs and Health-Related Quality of Life after Acute Ischemic Stroke: Analysis of ENCHANTED Alteplase Dose Arm', Cerebrovascular Diseases, 49, pp. 427 - 436, http://dx.doi.org/10.1159/000509226
    Journal articles | 2020
    Chen X; Wang X; Delcourt C; Li J; Arima H; Hackett ML; Robinson T; Lavados PM; Lindley RI; Chalmers J; Anderson CS, 2020, 'Ethnicity and Other Determinants of Quality of Functional Outcome in Acute Ischemic Stroke: The ENCHANTED Trial', Stroke, 51, pp. 588 - 593, http://dx.doi.org/10.1161/STROKEAHA.119.027639
    Journal articles | 2020
    Delcourt C; Wang X; Zhou Z; Wardlaw JM; Mair G; Robinson TG; Chen X; Yoshimura S; Torii-Yoshimura T; Carcel C; Calic Z; Tan WY; Malavera A; Anderson CS; Lindley RI, 2020, 'Brain imaging abnormalities and outcome after acute ischaemic stroke: The ENCHANTED trial', Journal of Neurology, Neurosurgery and Psychiatry, 91, pp. 1290 - 1296, http://dx.doi.org/10.1136/jnnp-2020-323015
    Journal articles | 2020
    Song L; Chen C; Wang X; Chen X; Ouyang M; Sun L; Hisatomi A; Robinson T; Lindley RI; Chalmers J; Li G; Anderson CS, 2020, 'Abstract TMP15: Asian versus Non-Asian, Differences in Characteristics, Management & Outcomes in the Enchanted Trial', Stroke, 51, http://dx.doi.org/10.1161/str.51.suppl_1.tmp15
    Journal articles | 2020
    Wang X; Moullaali TJ; Li Q; Berge E; Robinson TG; Lindley R; Zheng D; Delcourt C; Arima H; Song L; Chen X; Yang J; Chalmers J; Anderson CS; Sandset EC, 2020, 'Utility-Weighted Modified Rankin Scale Scores for the Assessment of Stroke Outcome: Pooled Analysis of 20 000+ Patients', Stroke, 51, pp. 2411 - 2417, http://dx.doi.org/10.1161/STROKEAHA.119.028523
    Journal articles | 2020
    Xia C; Wang X; Lindley RI; Delcourt C; Zhou Z; Chen X; Carcel C; Malavera A; Calic Z; Anderson CS, 2020, 'Combined utility of blood glucose and white blood cell in predicting outcome after acute ischemic stroke: The ENCHANTED trial', Clinical Neurology and Neurosurgery, 198, http://dx.doi.org/10.1016/j.clineuro.2020.106254
    Journal articles | 2020
    Zhou Z; Zhou Z; Yoshimura S; Delcourt C; Delcourt C; Delcourt C; Lindley RI; You S; You S; Malavera A; Torii-Yoshimura T; Carcel C; Carcel C; Wang X; Chen X; Parsons MW; Demchuk AM; Wardlaw JM; Mair G; Robinson TG; Chalmers J; Xu J; Anderson CS; Anderson CS; Anderson CS, 2020, 'Thrombolysis Outcomes in Acute Ischemic Stroke by Fluid-Attenuated Inversion Recovery Hyperintense Arteries', Stroke, 51, pp. 2240 - 2243, http://dx.doi.org/10.1161/STROKEAHA.119.028550
    Journal articles | 2019
    Anderson CS; Huang Y; Lindley RI; Chen X; Arima H; Chen G; Li Q; Billot L; Delcourt C; Bath PM; Broderick JP; Demchuk AM; Donnan GA; Durham AC; Lavados PM; Martins SO; Olavarria VV; Levi C; Parsons MW; Pontes-Neto OM; Ricci S; Sato S; Sharma VK; Silva F; Song L; Thang NH; Wardlaw JM; Wang JG; Wang X; Woodward M; Chalmers J; Robinson TG; Kim JS; Stapf C; Simes RJ; Hankey GJ; Sandercock P; Bousser MG; Wong KSL; Scaria A; Hirakawa Y; Moullaali TJ; Carcel C; Gordon P; Fuentes-Patarroyo SX; Benito D; Chen R; Cao Y; Kunchok A; Winters S; Coutts S; Yoshimura S; You S; Yang J; Wu G; Zhang S; Manning L; Mistri A; Haunton V; Minhas J; Malavera A; Lim J; Liu L; Kumar NN; Tay N; Jenson K; Richtering S; Tucker S; Knight E; Ivanova E; Thembani E; Odgers E; Sanders E; Small S; Vaghasiya R; Armenis M; Donnelly P; Baig MA; Blacklock N; Naidu B; Monaghan H; Smith P; Glass P; Bai X; Li Q; Zhu P; Kong L; He R; Zhao H; Lv J; Jia H; Xi Z; Cong Y; Cui B; Deng H; Guo Y; He L, 2019, 'Intensive blood pressure reduction with intravenous thrombolysis therapy for acute ischaemic stroke (ENCHANTED): an international, randomised, open-label, blinded-endpoint, phase 3 trial', The Lancet, 393, pp. 877 - 888, http://dx.doi.org/10.1016/S0140-6736(19)30038-8
    Journal articles | 2019
    Chen X; Anderson CS; Wang X; Robinson T; Lavados PM; Lindley RI; Chalmers J; Delcourt C, 2019, 'Abstract TP362: Comparison of the Simplified Modified Rankin Scale Questionnaire With Conventional Neurological Scales in the Dose Arm of the Enchanted Study', Stroke, 50, http://dx.doi.org/10.1161/str.50.suppl_1.tp362
    Journal articles | 2018
    Anderson CS; Woodward M; Arima H; Chen X; Lindley RI; Wang X; Chalmers J; Robinson TG, 2018, 'Statistical analysis plan for evaluating different intensities of blood pressure control in the ENhanced Control of Hypertension And Thrombolysis strokE stuDy.', International Journal of Stroke, pp. 1 - 4, http://dx.doi.org/10.1177/1747493018806170
    Journal articles | 2017
    Delcourt C; Sato S; Zhang S; Sandset EC; Zheng D; Chen X; Hackett ML; Arima H; Hata J; Heeley E; Salman RAS; Robinson T; Davies L; Lavados PM; Lindley RI; Stapf C; Chalmers J; Anderson CS; Li Q; Billot L; Neal B; Woodward M, 2017, 'Intracerebral hemorrhage location and outcome among INTERACT2 participants', Neurology, 88, pp. 1408 - 1414, http://dx.doi.org/10.1212/WNL.0000000000003771
    Journal articles | 2017
    Delcourt C; Zheng D; Chen X; Hackett M; Arima H; Hata J; Heeley E; Al-Shahi Salman R; Woodward M; Huang Y; Robinson T; Lavados PM; Lindley RI; Stapf C; Davies L; Chalmers J; Anderson CS; Sato S, 2017, 'Associations with health-related quality of life after intracerebral haemorrhage: Pooled analysis of INTERACT studies', Journal of Neurology, Neurosurgery and Psychiatry, 88, pp. 70 - 75, http://dx.doi.org/10.1136/jnnp-2016-314414
    Journal articles | 2017
    Song L; Wang X; Robinson T; Lindley RI; Arima H; Lavados PM; Chen X; Chalmers J; Anderson CS, 2017, 'Characteristics, management and response to alteplase in China versus non-China participants of the ENCHANTED trial', Stroke and Vascular Neurology, 2, pp. 53 - 58, http://dx.doi.org/10.1136/svn-2017-000085
    Journal articles | 2016
    Anderson CS; Robinson T; Lindley RI; Arima H; Lavados PM; Lee TH; Broderick JP; Chen X; Chen G; Sharma VK; Kim JS; Thang NH; Cao Y; Parsons MW; Levi C; Huang Y; Olavarría VV; Demchuk AM; Bath PM; Donnan GA; Martins S; Pontes-Neto OM; Silva F; Ricci S; Roffe C; Pandian J; Billot L; Woodward M; Li Q; Wang X; Wang J; Chalmers J, 2016, 'Low-dose versus standard-dose intravenous alteplase in acute ischemic stroke', New England Journal of Medicine, 374, pp. 2313 - 2323, http://dx.doi.org/10.1056/NEJMoa1515510
    Journal articles | 2016
    Yu S; Arima H; Heeley E; Delcourt C; Krause M; Peng B; Yang J; Wu G; Chen X; Chalmers J; Anderson CS, 2016, 'White blood cell count and clinical outcomes after intracerebral hemorrhage: The INTERACT2 trial', Journal of the Neurological Sciences, 361, pp. 112 - 116, http://dx.doi.org/10.1016/j.jns.2015.12.033
    Journal articles | 2015
    Anderson CS; Woodward M; Arima H; Chen X; Lindley RI; Wang X; Chalmers J, 2015, 'Statistical analysis plan for evaluating low- vs. Standard-dose alteplase in the ENhanced Control of Hypertension and Thrombolysis strokE stuDy (ENCHANTED)', International Journal of Stroke, 10, pp. 1313 - 1315, http://dx.doi.org/10.1111/ijs.12602
    Journal articles | 2015
    Huang Y; Sharma VK; Robinson T; Lindley RI; Chen X; Kim JS; Lavados P; Olavarría V; Arima H; Fuentes S; Nguyen HT; Lee TH; Parsons MW; Levi C; Demchuk AM; Bath PMW; Broderick JP; Donnan GA; Martins S; Pontes-Neto OM; Silva F; Pandian J; Ricci S; Stapf C; Woodward M; Wang J; Chalmers J; Anderson CS, 2015, 'Rationale, design, and progress of the ENhanced Control of Hypertension ANd Thrombolysis strokE stuDy (ENCHANTED) trial: An international multicenter 2×2 quasi-factorial randomized controlled trial of low- vs. standard-dose rt-PA and early intensive vs. guideline-recommended blood pressure lowering in patients with acute ischaemic stroke eligible for thrombolysis treatment', International Journal of Stroke, 10, pp. 778 - 788, http://dx.doi.org/10.1111/ijs.12486
    Journal articles | 2014
    Chen G; Arima H; Wu G; Heeley E; Delcourt C; Zhang P; Rabinstein AA; Robinson T; Stapf C; Huang Y; Song L; Yang J; Wang X; Li Q; Chen X; Chalmers J; Anderson C, 2014, 'Subarachnoid extension of intracerebral hemorrhage and 90-day outcomes in INTERACT2', Stroke, 45, pp. 258 - 260, http://dx.doi.org/10.1161/Strokeaha.113.003524
  • Conference Abstracts | 2019
    Chen X; Anderson CS; Wang X; Robinson T; Lavados PM; Lindley R; Chalmers J; Delcourt C, 2019, 'Comparison of the Simplified Modified Rankin Scale Questionnaire With Conventional Neurological Scales in the Dose Arm of the Enchanted Study.', in STROKE, LIPPINCOTT WILLIAMS & WILKINS, HI, Honolulu, Vol. 50, presented at American-Heart-Association/American-Stroke-Association International Stroke Conference / State-of-the-Science Stroke Nursing Symposium, HI, Honolulu, 06 February 2019 - 08 February 2019, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000478733401093&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2019
    Delcourt C; Zhou Z; Wang X; Wardlaw J; Mair G; Robinson T; Chen X; Yoshimura S; Torii-Yoshimura T; Carcel C; Calic Z; Tan W-Y; Malavera A; Anderson C; Lindley R, 2019, 'Baseline brain imaging signs and outcomes in the ENCHANTED trial', in INTERNATIONAL JOURNAL OF STROKE, SAGE PUBLICATIONS LTD, pp. 7 - 7
    Conference Papers | 2019
    Yang J; Song L; Li G; Chen X; Chen C; Liu F; Lin Y; Guo Y; Sun L; Arima H; Anderson CS, 2019, 'Intensive Ambulance-delivered Blood Pressure Reduction In Hyper-acute Stroke Trial', in CEREBROVASCULAR DISEASES, KARGER, Manila, Philippines, pp. 111 - 111, presented at APSC 2019, Manila, Philippines, 02 October 2019
    Conference Abstracts | 2019
    Zhou Z; Yoshimura S; Delcourt C; Lindley R; You S; Malavera A; Torii-Yoshimura T; Carcel C; Wang X; Chen X; Parsons M; Demchuk A; Wardlaw J; Mair G; Robinson T; Chalmers J; Xu J; Anderson C, 2019, 'Thrombolysis outcomes in acute ischemic stroke by FLAIR hyper intense arteries', in INTERNATIONAL JOURNAL OF STROKE, SAGE PUBLICATIONS LTD, Vol. 14, pp. 6 - 7, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000485243200021&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2017
    Ge X; Wang X; Anderson C; Chen X; Liu L; Li Q, 2017, 'Impact of Disparities in Acute Stroke Care Between High and Middle Income Countries', in CEREBROVASCULAR DISEASES, KARGER, pp. 2 - 3, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000415238400006&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2013
    Chen X; Anderson C; Robinson T; Lavados P; Fuentes S; Lindley R; Arima H; Kim JS; Lee T-A; Chalmers J, 2013, 'The Enhanced Control of Hypertension and Thrombolysis Stroke Study (ENCHANTED): Complexity of Set-Up Large International Clinical Trial', in CEREBROVASCULAR DISEASES, KARGER, pp. 20 - 20, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000323941400047&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Dr Chen is an early career researcher in Clinical trials and stroke.  She has vast experience in large scale stroke trials and has been pivotal to the success of multiple world-class large international clinical trials, including as Global Project Lead of The third, INTEnsive care bundle with blood pressure Reduction in Acute Cerebral haemorrhage Trial (INTERACT3) with 7000+ stroke patients enrolled from 130+ centres from 10 countries, Global Project Lead of the completed Intensive blood pressure reduction with intravenous thrombolysis therapy for acute ischaemic stroke (ENCHANTED), and Project manager of The Second Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT2) and The Sleep Apnea Cardiovascular Endpoints (SAVE) study.

As the Lead on stroke and digital health themes in Global Brain Health Program at the George Institute for Global Health, Dr Chen leads and collaborates with international experts on developing a multi-factorial, multi-arm, multi-stage, global randomised adaptive platform trial for stroke, and leads multiple digital health projects including OPTICS, a project to develop a decision supporting system which will be based on predictive models developed using deep learning techniques on the large amount of clinical data and imaging data in Intracerebral haemorrhage to assist clinician’s decision-making; FULMA, a project to develop an upper limb function assessment system with artificial intelligence and multimedia technology to help rehabilitation for chronic stroke patients with upper limb impairment; and CONNECT, a clinical trial to evaluate a medical device called Nuroflux which is a wearable device that can continuously monitor brain activities and blood flow, to demonstrate its efficacy in acute ischaemic stroke patients to detect neurological deteriorations.