Dr Yanchuan Shi

Dr Yanchuan Shi

Conjoint Associate Professor

Certificate from the Australian Medical Council (AMC); PhD from UNSW Sydney; MD from Harbin Medical University.

 

 

 

Medicine & Health
School of Clinical Medicine

A/Prof Yanchuan Shi is a clinician scientist and group leader of Neuroendocrinology at the Garvan Institute, who has over 14 years of experience studying metabolic disorders, including obesity, diabetes, and related cardiovascular diseases. Her work utlizes sophisticated transgenic mouse models, cutting edge molecular technologies, and human samples to investigate critical pathways involved in the development of obesity and diabetes. Her combination of expertise in clinical practice and basic research provides her with a unique advantage in conceiving highly clinical relevant research ideas and setting up experiments to test these hypotheses in the lab.

Phone
+61-2-9295 8530
Location
Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst 2010
  • Journal articles | 2024
    Lin F; Chen X; Cai Y; Shi Y; Wang Y; Zeng Y; Ye Q; Chen X; Wu X; Shi Y; Cai G, 2024, 'Accelerated biological aging as potential mediator mediates the relationship between pro-inflammatory diets and the risk of depression and anxiety: A prospective analysis from the UK biobank', Journal of Affective Disorders, 355, pp. 1 - 11, http://dx.doi.org/10.1016/j.jad.2024.03.135
    Journal articles | 2024
    Sue N; Thai LM; Saito A; Boyer CK; Fordham AM; Yan C; Davenport A; Tao J; Bensellam M; Cantley J; Shi YC; Stephens SB; Imaizumi K; Biden TJ, 2024, 'Independent activation of CREB3L2 by glucose fills a regulatory gap in mouse β-cells by co-ordinating insulin biosynthesis with secretory granule formation', Molecular Metabolism, 79, http://dx.doi.org/10.1016/j.molmet.2023.101845
    Journal articles | 2024
    Zhao XY; Wang JQ; Neely GG; Shi YC; Wang QP, 2024, 'Natural compounds as obesity pharmacotherapies', Phytotherapy Research, 38, pp. 797 - 838, http://dx.doi.org/10.1002/ptr.8083
    Journal articles | 2023
    Chen WH; Shi YC; Huang QY; Chen JM; Wang ZY; Lin S; Shi QY, 2023, 'Potential for NPY receptor–related therapies for polycystic ovary syndrome: an updated review', Hormones, 22, pp. 441 - 451, http://dx.doi.org/10.1007/s42000-023-00460-8
    Journal articles | 2023
    Conway JRW; Warren SC; Lee YK; McCulloch AT; Magenau A; Lee V; Metcalf XL; Stoehr J; Haigh K; Abdulkhalek L; Guaman CS; Reed DA; Murphy KJ; Pereira BA; Mélénec P; Chambers C; Latham SL; Lenthall H; Deenick EK; Ma Y; Phan T; Lim E; Joshua AM; Walters S; Grey ST; Shi YC; Zhang L; Herzog H; Croucher DR; Philp A; Scheele CLGJ; Herrmann D; Sansom OJ; Morton JP; Papa A; Haigh JJ; Nobis M; Timpson P, 2023, 'Monitoring AKT activity and targeting in live tissue and disease contexts using a real-time Akt-FRET biosensor mouse', Science Advances, 9, http://dx.doi.org/10.1126/sciadv.adf9063
    Journal articles | 2023
    Ip CK; Rezitis J; Qi Y; Bajaj N; Koller J; Farzi A; Shi YC; Tasan R; Zhang L; Herzog H, 2023, 'Critical role of lateral habenula circuits in the control of stress-induced palatable food consumption', Neuron, 111, pp. 2583 - 2600.e6, http://dx.doi.org/10.1016/j.neuron.2023.05.010
    Journal articles | 2023
    Li Y; Buys N; Ferguson S; Li Z; Shi YC; Li L; Sun J, 2023, 'The evaluation of cognitive-behavioral therapy-based intervention on type 2 diabetes patients with comorbid metabolic syndrome: a randomized controlled trial', Diabetology and Metabolic Syndrome, 15, http://dx.doi.org/10.1186/s13098-023-01100-2
    Journal articles | 2023
    Peng S; Wu WQ; Li LY; Shi YC; Lin S; Song ZY, 2023, 'Deficiency of neuropeptide Y attenuates neointima formation after vascular injury in mice', BMC Cardiovascular Disorders, 23, http://dx.doi.org/10.1186/s12872-023-03267-y
    Journal articles | 2023
    Shi YC, 2023, 'ACE2: A Dilemma in Regulating SARS-CoV-2 Infection and its Metabolic Complications', BIO Integration, 4, pp. 3 - 6, http://dx.doi.org/10.15212/bioi-2022-0026
    Journal articles | 2023
    Thai LM; O'Reilly L; Reibe-Pal S; Sue N; Holliday H; Small L; Schmitz-Peiffer C; Dhenni R; Wang-Wei Tsai V; Norris N; Yau B; Zhang X; Lee K; Yan C; Shi YC; Kebede MA; Brink R; Cooney GJ; Irvine KM; Breit SN; Phan TG; Swarbrick A; Biden TJ, 2023, 'β-cell function is regulated by metabolic and epigenetic programming of islet-associated macrophages, involving Axl, Mertk, and TGFβ receptor signaling', iScience, 26, http://dx.doi.org/10.1016/j.isci.2023.106477
    Journal articles | 2023
    Wang B; Wan AH; Xu Y; Zhang RX; Zhao BC; Zhao XY; Shi YC; Zhang X; Xue Y; Luo Y; Deng Y; Neely GG; Wan G; Wang QP, 2023, 'Identification of indocyanine green as a STT3B inhibitor against mushroom α-amanitin cytotoxicity', Nature Communications, 14, http://dx.doi.org/10.1038/s41467-023-37714-3
    Journal articles | 2023
    Wu Q; Burley G; Li LC; Lin S; Shi YC, 2023, 'The role of dietary salt in metabolism and energy balance: Insights beyond cardiovascular disease', Diabetes, Obesity and Metabolism, 25, pp. 1147 - 1161, http://dx.doi.org/10.1111/dom.14980
    Journal articles | 2023
    Zheng J; Chen L; Cai G; Wang Y; Huang J; Lin X; Li Y; Yu Q; Chen X; Shi Y; Ye Q, 2023, 'The effect of Parkin gene S/N 167 polymorphism on resting spontaneous brain functional activity in Parkinson's Disease', Parkinsonism and Related Disorders, 113, http://dx.doi.org/10.1016/j.parkreldis.2023.105484
    Journal articles | 2022
    Cai PY; Zheng YL; Zhou YF; Wang WD; Li MM; Shi YC; Lin HL; Lin S, 2022, 'Research progress on the role of exosomes in obstructive sleep apnea-hypopnea syndrome-related atherosclerosis', Sleep Medicine Reviews, 66, http://dx.doi.org/10.1016/j.smrv.2022.101696
    Journal articles | 2022
    Lai JQ; Shi YC; Lin S; Chen XR, 2022, 'Metabolic disorders on cognitive dysfunction after traumatic brain injury', Trends in Endocrinology and Metabolism, 33, pp. 451 - 462, http://dx.doi.org/10.1016/j.tem.2022.04.003
    Journal articles | 2022
    Lee K; Chan JY; Liang C; Ip CK; Shi YC; Herzog H; Hughes WE; Bensellam M; Delghingaro-Augusto V; Koina ME; Nolan CJ; Laybutt DR, 2022, 'XBP1 maintains beta cell identity, represses beta-to-alpha cell transdifferentiation and protects against diabetic beta cell failure during metabolic stress in mice', Diabetologia, 65, pp. 984 - 996, http://dx.doi.org/10.1007/s00125-022-05669-7
    Journal articles | 2022
    Liang B; Burley G; Lin S; Shi YC, 2022, 'Osteoporosis pathogenesis and treatment: existing and emerging avenues', Cellular and Molecular Biology Letters, 27, http://dx.doi.org/10.1186/s11658-022-00371-3
    Journal articles | 2022
    Yang CH; Ann-Onda D; Lin X; Fynch S; Nadarajah S; Pappas EG; Liu X; Scott JW; Oakhill JS; Galic S; Shi Y; Moreno-Asso A; Smith C; Loudovaris T; Levinger I; Eizirik DL; Laybutt DR; Herzog H; Thomas HE; Loh K, 2022, 'Neuropeptide Y1 receptor antagonism protects β-cells and improves glycemic control in type 2 diabetes', Molecular Metabolism, 55, http://dx.doi.org/10.1016/j.molmet.2021.101413
    Journal articles | 2022
    Yang YS; He SL; Chen WC; Wang CM; Huang QM; Shi YC; Lin S; He HF, 2022, 'Recent progress on the role of non-coding RNA in postoperative cognitive dysfunction', Frontiers in Cellular Neuroscience, 16, http://dx.doi.org/10.3389/fncel.2022.1024475
    Journal articles | 2022
    Zammit NW; McDowell J; Warren J; Muskovic W; Gamble J; Shi YC; Kaczorowski D; Chan CL; Powell J; Ormandy C; Brown D; Oakes SR; Grey ST, 2022, 'TNFAIP3 Reduction-of-Function Drives Female Infertility and CNS Inflammation', Frontiers in Immunology, 13, http://dx.doi.org/10.3389/fimmu.2022.811525
    Journal articles | 2022
    Zhang CL; Lin YZ; Wu Q; Yan C; Wong MWK; Zeng F; Zhu P; Bowes K; Lee K; Zhang X; Song ZY; Lin S; Shi YC, 2022, 'Arcuate NPY is involved in salt-induced hypertension via modulation of paraventricular vasopressin and brain-derived neurotrophic factor', Journal of Cellular Physiology, 237, pp. 2574 - 2588, http://dx.doi.org/10.1002/jcp.30719
    Journal articles | 2021
    Wu W; Peng S; Shi Y; Li L; Song Z; Lin S, 2021, 'NPY promotes macrophage migration by upregulating matrix metalloproteinase-8 expression', Journal of Cellular Physiology, 236, pp. 1903 - 1912, http://dx.doi.org/10.1002/jcp.29973
    Journal articles | 2021
    Yan C; Zeng T; Lee K; Nobis M; Loh K; Gou L; Xia Z; Gao Z; Bensellam M; Hughes W; Lau J; Zhang L; Ip CK; Enriquez R; Gao H; Wang QP; Wu Q; Haigh JJ; Laybutt DR; Timpson P; Herzog H; Shi YC, 2021, 'Peripheral-specific Y1 receptor antagonism increases thermogenesis and protects against diet-induced obesity', Nature Communications, 12, http://dx.doi.org/10.1038/s41467-021-22925-3
    Journal articles | 2021
    Yu J; Shi YC; Ping F; Li W; Zhang HB; He SL; Zhao Y; Xu LL; Li YX, 2021, 'Liraglutide Inhibits Osteoclastogenesis and Improves Bone Loss by Downregulating Trem2 in Female Type 1 Diabetic Mice: Findings From Transcriptomics', Frontiers in Endocrinology, 12, http://dx.doi.org/10.3389/fendo.2021.763646
    Journal articles | 2021
    Zhang Y; Liu CY; Chen WC; Shi YC; Wang CM; Lin S; He HF, 2021, 'Regulation of neuropeptide Y in body microenvironments and its potential application in therapies: a review', Cell and Bioscience, 11, http://dx.doi.org/10.1186/s13578-021-00657-7
    Journal articles | 2021
    Zhao YX; Chen SR; Huang QY; Chen WC; Xia T; Shi YC; Gao HZ; Shi QY; Lin S, 2021, 'Repair abilities of mouse autologous adipose-derived stem cells and ShakeGel™3D complex local injection with intrauterine adhesion by BMP7-Smad5 signaling pathway activation', Stem Cell Research and Therapy, 12, pp. 191, http://dx.doi.org/10.1186/s13287-021-02258-0
    Journal articles | 2020
    Hu X; Zhou J; Song SS; Kong W; Shi YC; Chen LL; Zeng TS, 2020, 'TLR4/AP-1-Targeted Anti-Inflammatory Intervention Attenuates Insulin Sensitivity and Liver Steatosis', Mediators of Inflammation, 2020, http://dx.doi.org/10.1155/2020/2960517
    Journal articles | 2020
    Wan XQ; Zeng F; Huang XF; Yang HQ; Wang L; Shi YC; Zhang ZH; Lin S, 2020, 'Risperidone stimulates food intake and induces body weight gain via the hypothalamic arcuate nucleus 5-HT2c receptor—NPY pathway', CNS Neuroscience and Therapeutics, 26, pp. 558 - 566, http://dx.doi.org/10.1111/cns.13281
    Journal articles | 2020
    Wang QP; Lin YQ; Lai ML; Su Z; Oyston LJ; Clark T; Park SJ; Khuong TM; Lau MT; Shenton V; Shi YC; James DE; Ja WW; Herzog H; Simpson SJ; Neely GG, 2020, 'PGC1α Controls Sucrose Taste Sensitization in Drosophila', Cell Reports, 31, http://dx.doi.org/10.1016/j.celrep.2020.03.044
    Journal articles | 2019
    Bensellam M; Shi YC; Chan JY; Laybutt DR; Chae H; Abou-Samra M; Pappas EG; Thomas HE; Gilon P; Jonas JC, 2019, 'Metallothionein 1 negatively regulates glucose-stimulated insulin secretion and is differentially expressed in conditions of beta cell compensation and failure in mice and humans', Diabetologia, 62, pp. 2273 - 2286, http://dx.doi.org/10.1007/s00125-019-05008-3
    Journal articles | 2019
    Chen X; Zhou Y-L; Liang S-Y; Shi Y-C; Lin S; Shu M-Q, 2019, 'Overexpression of UHRF1 promoted the proliferation of vascular smooth cells via the regulation of Geminin protein levels', BIOSCIENCE REPORTS, 39, http://dx.doi.org/10.1042/BSR20181341
    Journal articles | 2019
    Ip CK; Zhang L; Farzi A; Qi Y; Clarke I; Reed F; Shi YC; Enriquez R; Dayas C; Graham B; Begg D; Brüning JC; Lee NJ; Hernandez-Sanchez D; Gopalasingam G; Koller J; Tasan R; Sperk G; Herzog H, 2019, 'Amygdala NPY Circuits Promote the Development of Accelerated Obesity under Chronic Stress Conditions', Cell Metabolism, 30, pp. 111 - 128.e6, http://dx.doi.org/10.1016/j.cmet.2019.04.001
    Journal articles | 2019
    Liu Y; Yu J; Shi YC; Zhang Y; Lin S, 2019, 'The role of inflammation and endoplasmic reticulum stress in obesity-related cognitive impairment', Life Sciences, 233, http://dx.doi.org/10.1016/j.lfs.2019.116707
    Journal articles | 2019
    Yi TY; Chen WH; Wu YM; Zhang MF; Zhan AL; Chen YH; Wu ZZ; Shi YC; Chen BL, 2019, 'Microcatheter "first-Pass Effect" Predicts Acute Intracranial Artery Atherosclerotic Disease-Related Occlusion', Clinical Neurosurgery, 84, pp. 1296 - 1305, http://dx.doi.org/10.1093/neuros/nyy183
    Journal articles | 2019
    Zhao YX; Chen SR; Su PP; Huang FH; Shi YC; Shi QY; Lin S, 2019, 'Using Mesenchymal Stem Cells to Treat Female Infertility: An Update on Female Reproductive Diseases', Stem Cells International, 2019, http://dx.doi.org/10.1155/2019/9071720
    Journal articles | 2018
    Farzi A; Lau J; Ip CK; Qi Y; Shi YC; Zhang L; Tasan R; Sperk G; Herzog H, 2018, 'Arcuate nucleus and lateral hypothalamic cart neurons in the mouse brain exert opposing effects on energy expenditure', eLife, 7, http://dx.doi.org/10.7554/eLife.36494
    Journal articles | 2018
    Lau J; Farzi A; Qi Y; Heilbronn R; Mietzsch M; Shi YC; Herzog H, 2018, 'CART neurons in the arcuate nucleus and lateral hypothalamic area exert differential controls on energy homeostasis', Molecular Metabolism, 7, pp. 102 - 118, http://dx.doi.org/10.1016/j.molmet.2017.10.015
    Journal articles | 2018
    Loh K; Shi YC; Bensellam M; Lee K; Laybutt DR; Herzog H, 2018, 'Y1 receptor deficiency in β-cells leads to increased adiposity and impaired glucose metabolism', Scientific Reports, 8, http://dx.doi.org/10.1038/s41598-018-30140-2
    Journal articles | 2018
    Zhu P; Zhang ZH; Huang XF; Shi YC; Khandekar N; Yang HQ; Liang SY; Song ZY; Lin S, 2018, 'Cold exposure promotes obesity and impairs glucose homeostasis in mice subjected to a high-fat diet', Molecular Medicine Reports, 18, pp. 3923 - 3931, http://dx.doi.org/10.3892/mmr.2018.9382
    Journal articles | 2017
    Lau J; Farzi A; Enriquez RF; Shi YC; Herzog H, 2017, 'GPR88 is a critical regulator of feeding and body composition in mice', Scientific Reports, 7, pp. 9912, http://dx.doi.org/10.1038/s41598-017-10058-x
    Journal articles | 2017
    Loh K; Shi YC; Walters S; Bensellam M; Lee K; Dezaki K; Nakata M; Ip CK; Chan JY; Gurzov EN; Thomas HE; Waibel M; Cantley J; Kay TW; Yada T; Laybutt DR; Grey ST; Herzog H, 2017, 'Inhibition of Y1 receptor signaling improves islet transplant outcome', Nature Communications, 8, http://dx.doi.org/10.1038/s41467-017-00624-2
    Journal articles | 2017
    Shi YC; Ip CK; Reed F; Sarruf DA; Wulff BS; Herzog H, 2017, 'Y5 receptor signalling counteracts the anorectic effects of PYY3-36 in diet-induced obese mice', Journal of Neuroendocrinology, 29, http://dx.doi.org/10.1111/jne.12483
    Journal articles | 2017
    Sun W-W; Li L-Y; Huang X-F; Shi Y-C; Yang H-Q; Song Z-Y; Lin S, 2017, 'The central mechanism of risperidone-induced hyperprolactinemia', PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 76, pp. 134 - 139, http://dx.doi.org/10.1016/j.pnpbp.2017.03.009
    Journal articles | 2017
    Sun WW; Li LY; Huang XF; Shi YC; Yang HQ; Song ZY; Lin S, 2017, 'The central mechanism of risperidone-induced hyperprolactinemia', Progress in Neuro-Psychopharmacology and Biological Psychiatry, 76, pp. 134 - 139, http://dx.doi.org/10.1016/j.pnpbp.2017.03.009
    Journal articles | 2017
    Sun WW; Zhu P; Shi YC; Zhang CL; Huang XF; Liang SY; Song ZY; Lin S, 2017, 'Current views on neuropeptide y and diabetes-related atherosclerosis', Diabetes and Vascular Disease Research, 14, pp. 277 - 284, http://dx.doi.org/10.1177/1479164117704380
    Journal articles | 2017
    Worton LE; Shi YC; Smith EJ; Barry SC; Gonda TJ; Whitehead JP; Gardiner EM, 2017, 'Ectodermal-Neural Cortex 1 Isoforms Have Contrasting Effects on MC3T3-E1 Osteoblast Mineralization and Gene Expression', Journal of Cellular Biochemistry, 118, pp. 2141 - 2150, http://dx.doi.org/10.1002/jcb.25851
    Journal articles | 2016
    Lau J; Shi YC; Herzog H, 2016, 'Temperature dependence of the control of energy homeostasis requires CART signaling', Neuropeptides, 59, pp. 97 - 109, http://dx.doi.org/10.1016/j.npep.2016.03.006
    Journal articles | 2016
    Seimon RV; Shi YC; Slack K; Lee K; Fernando HA; Nguyen AD; Zhang L; Lin S; Enriquez RF; Lau J; Herzog H; Sainsbury A, 2016, 'Intermittent Moderate Energy Restriction Improves Weight Loss Efficiency in Diet-Induced Obese Mice', PLoS ONE, 11, http://dx.doi.org/10.1371/journal.pone.0145157
    Journal articles | 2015
    Loh K; Herzog H; Shi YC, 2015, 'Regulation of energy homeostasis by the NPY system', Trends in Endocrinology and Metabolism, 26, pp. 125 - 135, http://dx.doi.org/10.1016/j.tem.2015.01.003
    Journal articles | 2015
    Shi YC; Loh K; Bensellam M; Lee K; Zhai L; Lau J; Cantley J; Luzuriaga J; Laybutt DR; Herzog H, 2015, 'Pancreatic PYY is critical in the control of insulin secretion and glucose homeostasis in female mice', Endocrinology (United States), 156, pp. 3122 - 3136, http://dx.doi.org/10.1210/en.2015-1168
    Journal articles | 2014
    Baldock PA; Lin S; Zhang L; Karl T; Shi Y; Driessler F; Zengin A; Hörmer B; Lee NJ; Wong IPL; Lin EJD; Enriquez RF; Stehrer B; During MJ; Yulyaningsih E; Zolotukhin S; Ruohonen ST; Savontaus E; Sainsbury A; Herzog H, 2014, 'Neuropeptide Y attenuates stress-induced bone loss through suppression of noradrenaline circuits', Journal of Bone and Mineral Research, 29, pp. 2238 - 2249, http://dx.doi.org/10.1002/jbmr.2205
    Journal articles | 2014
    Nguyen AD; Slack K; Schwarzer C; Lee NJ; Boey D; Macia L; Yulyaningsih E; Enriquez RF; Zhang L; Lin S; Shi YC; Baldock PA; Herzog H; Sainsbury A, 2014, 'Double deletion of orexigenic neuropeptide Y and dynorphin results in paradoxical obesity in mice', Neuropeptides, 48, pp. 143 - 151, http://dx.doi.org/10.1016/j.npep.2014.03.001
    Journal articles | 2014
    Yulyaningsih E; Loh K; Lin S; Lau J; Zhang L; Shi Y; Berning BA; Enriquez R; Driessler F; Macia L; Khor EC; Qi Y; Baldock P; Sainsbury A; Herzog H, 2014, 'Pancreatic polypeptide controls energy homeostasis via Npy6r signaling in the suprachiasmatic nucleus in mice', Cell Metabolism, 19, pp. 58 - 72, http://dx.doi.org/10.1016/j.cmet.2013.11.019
    Journal articles | 2013
    Seimon RV; Slack K; Shi Y; Zhang L; Lin S; Enriquez RF; Herzog H; Salis AS, 2013, 'Intermittent energy restriction improves fat loss efficiency in diet-induced obese mice', Obesity Research & Clinical Practice, 7, pp. e25 - e25, http://dx.doi.org/10.1016/j.orcp.2013.12.550
    Journal articles | 2013
    Shi YC; Lau J; Lin Z; Zhang H; Zhai L; Sperk G; Heilbronn R; Mietzsch M; Weger S; Huang XF; Enriquez R; Castillo L; Baldock P; Zhang L; Sainsbury A; Herzog H; Lin S, 2013, 'Erratum: Arcuate NPY controls sympathetic output and BAT function via a relay of tyrosine hydroxylase neurons in the PVN (Cell Metabolism 17 (236-248))', Cell Metabolism, 18, pp. 144, http://dx.doi.org/10.1016/j.cmet.2013.06.012
    Journal articles | 2013
    Shi YC; Lau J; Lin Z; Zhang H; Zhai L; Sperk G; Heilbronn R; Mietzsch M; Weger S; Huang XF; Enriquez RF; Baldock PA; Zhang L; Sainsbury A; Herzog H; Lin S, 2013, 'Arcuate NPY controls sympathetic output and BAT function via a relay of tyrosine hydroxylase neurons in the PVN', Cell Metabolism, 17, pp. 236 - 248, http://dx.doi.org/10.1016/j.cmet.2013.01.006
    Journal articles | 2013
    Shi YC; Lin Z; Lau J; Zhang H; Yagi M; Kanzler I; Sainsbury A; Herzog H; Lin S, 2013, 'PYY3-36 and pancreatic polypeptide reduce food intake in an additive manner via distinct hypothalamic dependent pathways in mice', Obesity, 21, http://dx.doi.org/10.1002/oby.20534
    Journal articles | 2012
    Baldock PA; Driessler F; Lin S; Wong I; Shi Y; Yulyaningsih E; Castillo L; Janmaat S; Enriquez R; Zengin A; Kieffer B; Schwarzer C; Eisman JA; Sainsbury-Salis A; Herzog H, 2012, 'The endogenous opioid dynorphin is required for normal bone homeostasis in mice', Neuropeptides, 46, pp. 383 - 394, http://dx.doi.org/10.1016/j.npep.2012.08.010
    Journal articles | 2012
    Macia L; Yulyaningsih E; Pangon L; Nguyen AD; Lin S; Shi Y; Zhang L; Bijker MS; Grey ST; Mackay F; Herzog H; Sainsbury-Salis A, 2012, 'Neuropeptide y1 receptor in immune cells regulates inflammation and insulin resistance associated with diet-induced obesity', Diabetes, 61, pp. 3228 - 3238, http://dx.doi.org/10.2337/db12-0156
    Journal articles | 2012
    Nguyen AD; Mitchell NF; Lin S; Macia L; Yulyaningsih E; Baldock PA; Enriquez R; Zhang L; Shi Y; Zolotukhin S; Herzog H; Sainsbury-Salis A, 2012, 'Y1 and y5 receptors are both required for the regulation of food intake and energy homeostasis in mice', PLoS ONE, 7, pp. e40191, http://dx.doi.org/10.1371/journal.pone.0040191
    Journal articles | 2012
    Wong I; Driessler F; Khor EC; Shi Y; Hormer B; Nguyen AD; Enriquez R; Eisman JA; Sainsbury-Salis A; Herzog H; Baldock PA, 2012, 'Peptide YY regulates bone remodeling in mice: a link between gut and skeletal biology', PLoS One, 7, pp. e40038, http://dx.doi.org/10.1371/journal.pone.0040038
    Journal articles | 2012
    Zhang L; Nguyen A; Lee I; Yulyaningsih E; Riepler S; Stehrer B; Enriquez R; Lin S; Shi Y; Baldock PA; Sainsbury-Salis A; Herzog H, 2012, 'NPY modulates PYY function in the regulation of energy balance and glucose homeostasis', Diabetes Obesity and Metabolism, 14, pp. 727 - 736, http://dx.doi.org/10.1111/j.1463-1326.2012.01592.x
    Journal articles | 2009
    Baldock PA; Lee NJ; Driessler F; Lin S; Allison SJ; Stehrer B; Enriquez R; Zhang L; Lin E; Wong I; Mcdonald M; During M; Pierroz D; Slack K; Shi Y; Yulyaningsih E; Aljanova A; Little DG; Ferrari S; Sainsbury-Salis A; Eisman JA; Herzog H, 2009, 'Neuropeptide Y knockout mice reveal a central role of NPY in the coordination of bone mass to body weight', PLoS Clinical Trials, 4, pp. e8415 - e
    Journal articles | 2009
    Lin S; Shi Y; Yulyaningsih E; Aljanova A; Macia L; Nguyen A; Lin ED; Zhang L; During M; Herzog H; Sainsbury A, 2009, 'Critical role of arcuate Y4 receptors and the melanocortin system in pancreatic polypeptide-induced reduction in food intake in mice', PLoS One, 4, pp. 8488, http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=20041129
    Journal articles | 2007
    Shi Y; Worton L; Esteban L; Baldock P; Fong C; Eisman JA; Gardiner EM, 2007, 'Effects of continuous activation of vitamin D and Wnt response pathways on osteoblastic proliferation and differentiation', Bone, 41, pp. 87 - 96
    Journal articles | 2004
    Shi YD; Worton L; Eisman JA; Gardiner EM, 2004, '1,25(OH)2D3 regulates Wnt signaling pathway in osteblast-like MC3T3-E1 cells', Journal of Bone and Mineral Research, 19, pp. S271 - S271, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000224326801442&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
  • Preprints | 2021
    Yang C-H; Ann-Onda D; Lin X; Fynch S; Nadarajah S; Pappas E; Liu X; Scott JW; Oakhill JS; Galic S; Shi Y; Moreno-Asso A; Smith C; Loudovaris T; Levinger I; Eizirik DL; Laybutt RD; Herzog H; Thomas HE; Loh K, 2021, Elevated Neuropeptide Y1 Receptor Signaling Contributes to β-cell Dysfunction and Failure in Type 2 Diabetes, , http://dx.doi.org/10.1101/2021.05.14.444149
    Conference Papers | 2016
    Walters S; Loh K; Shi Y-C; Lee K; Herzog H; Grey S, 2016, 'Y1 receptor antagonism enhances insulin secretion and improves islet transplantation efficiency', in TRANSPLANTATION, LIPPINCOTT WILLIAMS & WILKINS, pp. S90 - S90, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000436953200145&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2002
    Zhu W; Thomas GP; Worton LE; Baldock PA; Enriquez RF; Bake SUK; Alles CM; Shi Y; Eisman JA; Gardiner EM, 2002, 'Increased Wnt-frizzled gene expression in cortical bone from transgenic mice with elevated osteoblastic VDR expression.', in JOURNAL OF BONE AND MINERAL RESEARCH, AMER SOC BONE & MINERAL RES, TEXAS, SAN ANTONIO, pp. S152 - S153, presented at 24th Annual Meeting of the American-Society-for-Bone-and-Mineral-Research, TEXAS, SAN ANTONIO, 20 September 2002 - 24 September 2002, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000177952800118&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Since establishing her independent lab at Garvan Institute of Medical Research in Nov 2014, she has secured 3 NHMRC Project or Ideas grants as CIA or sole CI (2017, 2018, 2022), and 4 Diabetes Australia DART grants (category one) as sole CI (2016, 2018, 2019, 2021).

Travel grant: ANZBMS Annual Scientific Meeting in Perth in 2005

WHO fellowship: Visit the Royal Adelaide Hospital for one year in 2001.

 

  • Central and peripheral control of appetite, body weight, adiposity, and pancreatic beta cell function in obesity, diabetes, their related cardiovascular diseases (CVD) like hypertension, and osteoporosis.
  • Inter-organ cross talk, especially communication networks between the brain, fat tissue (white and brown) and pancreatic beta cells.
  • How lifestyle factors such as fasting, exercise and non-caloric nutrients (i.e. salt) modulate energy and glucose homeostasis, and inter-organ communication dynamics.

My Research Supervision

As primary supervisor, I am currently supervising 4 PhD students:

Ms Jade Zhang

Mr Loki Yan

Mr Kevin Wu

Mr Divyesh Naidu