Professor Adelle   Coster
Head of School

Professor Adelle Coster

Science
Sch of Mathematics & Statistic

Biography

I am an applied mathematician.  I use dynamical systems analyses, stochastic modelling and queueing theory, amongst other techniques to answer questions arising from fields other than mathematics.  My research is in mathematical modelling, particularly in biomedicine and biology. The investigations in which I am currently involved range from understanding the dynamics of fundamental protein-protein interactions, cellular processes, the geometrical morphological features of microfossils, to the interactions in systems at larger scales involving human subjects. Projects include the modelling of

  • cellular glucose transport in response to insulin and the deleterious effects insulin resistance and diabetes;
  • the dynamics of electrically excitable cells such as peripheral nerves and the cardiac pacemaker; and
  • starch grains within edible plants, allowing the identification of both contemporary grains and those found on ancient tools

Education

  • PhD, 1998 University of New South Wales
  • BSc, First Class Honours, University Medal, 1991 University of New South Wales

RESEARCH

Research Opportunities

I am looking for a Research Associate to undertake collaborative and self-directed research on an ARC-funded Discovery Project titled "The mathematics of stochastic transport and signalling in cells". The aim of the project is to develop new stochastic mathematical models of the dynamics of protein transport and cell signalling.

The mathematics will link macro scale biological observations to micro scale molecular movements to characterise the relative role that different components and processes play. Expected outcomes are robust mathematical analyses of the transient dynamics of closed, finite capacity queueing networks and biological insight into the major control mechanisms in cellular insulin signalling. A major objective is the development of methods to quantitatively compare the time courses of stochastic measurements with the outputs of stochastic mathematical models, with a view to driving parameter inference and model selection in these systems.

The position is based at UNSW Sydney and is for up to 3 years. Applications close on May 10, 2021.

Women and people from diverse backgrounds are encouraged to apply.

See https://external-careers.jobs.unsw.edu.au/cw/en/job/501605/research-associate for details.

There are also opportunities for students to get involved in the project. Please get in contact if you are interested.

Research Goals

To use mathematics to go where other disciplines cannot go alone. To develop novel and quantitative insight into interesting biological problems.

Research in Detail

Interdisciplinary research flourishes with the interaction of different discipline experts.  Some of the projects and the collaborators with whom I'm involved are outlined below.

Insulin Signalling, Glucose Transport and Metabolic Health

My research in this area is in collaboration with experimentalists such as Cynthia Mastick of the University of Nevada, Reno, USA, David James at the University of Sydney and Dorit Samocha-Bonet at the Garvan Institute for Medical Research, Sydney. The work focuses on creation of mathematical models that robustly and quantitatively describe the movement of glucose transporters within cells, and how this is regulated and controlled by the insulin signalling network. The quantitative understanding of this dynamic system under normal conditions is essential to the future understanding of the mechanisms underlying insulin resistance and its subsequent progression to Type 2 diabetes. One of the key outcomes will be the ability to quantitatively analyse the impact of differentially regulating the activity of components of the insulin signalling network, and, in the future, be a step in the process of drug design.

An important aspect of this is the integration of the information from various sources including cellular assays, western blot and mass spectrometry techniques as well as single cell experiments using total internal reflection fluorescence (TIRF) microscopy. In order to understand complex images seen in the latter, mathematical models of vesicular events as seen by TIRF were derived as part of the development of automated image analysis and event detection software. This enables the processing of large amounts of biological information which would otherwise be untenable. It also means that the results gathered are robust.

At a higher level, I employ bioinformatic techniques to correlate and understand the large lipidomic and proteomic data sets gathered from studies into the insulin response in human plasma and muscle.

Excitable Cells

The ionic currents underlying the electrical behaviour of neurons and pacemaker cells in the heart may be described using coupled nonlinear differential equations. These have been derived in a number of different models from a wide range of electrophysiological data in the literature.

In the cardiac system the dynamics of both single cells and coupled networks of cells is being explored, and the robustness of the models to changes in parameters ascertained. Different models for the sinoatrial node cells are assessed both analytically and computationally, correlating the different responses with the ionic currents, with a view to further optimising the system.

Explorations are being made of mathematical models of the human motor axon that utilise coupled differential equations to describe the electrical activity within the nerve. These models are being used to interpret the measured responses to extended hyperpolarization and the contribution of different ion currents to the transmission of signals. The responses of sensory neurons to strong long-lasting hyperpolarization are being assessed and contrasted with motor neurons. Extensions to the models are being made to incorporate additional inhomogeneities within the neuron structure. This project is in collaboration with James Howells at the University of Sydney.

Protein-protein interactions: Modelling the interplay between tropomyosin and actin

A combination of, both continuous dynamical systems and discrete mathematical modelling and single molecule fluorescence microscopy is being used to probe the dynamic interactions of two proteins, actin and tropomyosin. With experimental partners including Till Böcking in the Faculty of Medicine the aim is to resolve how filaments of these proteins are assembled. This is important because these proteins form the cytoskeleton (the internal scaffolding) of cells. Understanding of their interactions can then be used in the future to understand how drugs can target specific components and functions of the cytoskeleton that are hijacked in cancer cells. This project focuses on the formulation of a quantitative dynamical description of the processes taking place, using experimental information to estimate meaningful and quantitative parameters to robustly test and adapt the models of the dynamical systems, enabling the differentiation between different hypotheses of mechanism and function in this interaction. Analysis of microscopy image sequences and deconstruction into a basis set for the laments are being used to estimate the rate constants of the processes. Computational work for image processing as well as analysis is being undertaken alongside dynamical systems modelling.

Identification and Classification of Starch Grains

Moving away from dynamical systems, another interesting problem that benefits from a mathematical approach arises in the identification of the food sources ground on ancient stone tools.  This involves the analysis of starch grains in the residue found on the tools.  I have developed mathematical methods and software based on Fourier decomposition and shape analysis to quantify the geometric morphometric features of the starch grains from microscopy images.  Machine learning algorithms are then developed to classify and characterise the grains, comparing the unknown archeological samples to that from reference material from plants in the region. This work is in collaboration with Judith Field of the School of Biology, Earth and Environmental Sciences.

Recent Research Grants

  • ARC Discovery Project 2021-2023, The mathematics of stochastic transport and signalling in cells
  • ARC Discovery Project 2018-2020, Dynamical systems theory and mathematical modelling of viral infections, with Peter Kim, Federico Frascoli and Chae-Ok Yun.
  • ARC Discovery Project 2013-2015, Resolving the mechanisms of actin filament specialisation through single molecule analysis and modelling, with Till Böcking.

Student Projects (PhD and Honours)

Topics include, but are not limited to those above, i.e.

  • Mathematical modelling of the insulin signalling pathway and glucose transport,
  • The dynamics and stability of cardiac pacemaker cells, and
  • Modelling the interaction of actin and tropomyosin.

Please email me if you are interested in these or other biomathematical projects. Please include some information about your mathematical background and interests.

Advice for prospective students

Maths and science are the building blocks for understanding the world around you. Enjoy, be passionate and above all have fun with your studies. You will find that this will intensify as you discover your specific specialty. Interdisciplinary research is particularly exciting as it integrates the techniques and knowledge of, for instance, biology and mathematics, to create much deeper understanding of the problems than either discipline alone.

 

TEACHING & OUTREACH

 

Courses I teach

I am currently involved in subjects such as

MATH1131 Mathematics 1A

MATH3041 Mathematical Modelling for Real World Systems

MATH3201 Dynamical Systems and Chaos

MATH6781 Biomathematics

MATH3121 Mathematical Methods and Partial Differential Equations

Professional affiliations and service positions

I am currently the Head of the School of Mathematics & Statistics.

Past-President of the Australian Society for Biophysics.

I am a former member of the UNSW Academic Board and serve on many School, Faculty and University committees.

 

Phone
+61 2 9385 7048
Location
School of Mathematics and Statistics University of New South Wales Sydney NSW 2052 The Red Centre Room 2086

Publications

  • Book Chapters | 2021
    Professor Adelle Coster
    Gray CW; Coster ACF, 2021, 'Models of Membrane-Mediated Processes: Cascades and Cycles in Insulin Action', in Systems Medicine, Elsevier, pp. 143 - 155, http://dx.doi.org/10.1016/b978-0-12-801238-3.11348-0
    Book Chapters | 2018
    Professor Adelle Coster
    Coster ACF; Field JH, 2018, 'The Shape of Things to Come—Using Geometric and Morphometric Analyses to Identify Archaeological Starch Grains', in Agriculture as a Metaphor for Creativity in All Human Endeavors, Springer Singapore, pp. 1 - 6, http://dx.doi.org/10.1007/978-981-10-7811-8_1
    Book Chapters | 2008
    Professor Adelle Coster
    Govers R; James DE; Coster A, 2008, 'High-throughput analysis of the dynamics of recycling cell surface proteins', in Ivanov AI (ed.), Exocytosis and Endocytosis, Humana Press, NJ USA, pp. 129 - 146, http://dx.doi.org/10.1007/978-1-59745-178-9_10
    Book Chapters | 1995
    Professor Adelle Coster
    Coster A, 1995, 'Neural Thermodynamics for Biological Ensembles', in Cho S; Oh J-H; Kwon C (ed.), Neural Networks: The Statistical Mechanics Perspective, edn. Progress in Neural Processing, World Scientific Publishing Company Incorporated
  • Journal articles | 2021
    Professor Adelle Coster
    Hayes EH; Field JH; Coster ACF; Fullagar R; Matheson C; Florin SA; Nango M; Djandjomerr D; Marwick B; Wallis LA; Smith MA; Clarkson C, 2021, 'Holocene grinding stones at Madjedbebe reveal the processing of starchy plant taxa and animal tissue', Journal of Archaeological Science: Reports, vol. 35, http://dx.doi.org/10.1016/j.jasrep.2020.102754
    Journal articles | 2020
    Professor Adelle Coster
    Harari A; Coster ACF; Jenkins A; Xu A; Greenfield JR; Harats D; Shaish A; Samocha-Bonet D, 2020, 'Obesity and Insulin Resistance Are Inversely Associated with Serum and Adipose Tissue Carotenoid Concentrations in Adults', Journal of Nutrition, vol. 150, pp. 38 - 46, http://dx.doi.org/10.1093/jn/nxz184
    Journal articles | 2020
    Professor Adelle Coster
    Jenner AL; Frascoli F; Coster ACF; Kim PS, 2020, 'Enhancing oncolytic virotherapy: Observations from a Voronoi Cell-Based model', Journal of Theoretical Biology, vol. 485, pp. 110052 - 110052, http://dx.doi.org/10.1016/j.jtbi.2019.110052
    Journal articles | 2020
    Professor Adelle Coster
    Amorim NML; Kee A; Coster ACF; Lucas C; Bould S; Daniel S; Weir JM; Mellett NA; Barbour J; Meikle PJ; Cohn RJ; Turner N; Hardeman EC; Simar D, 2020, 'Irradiation impairs mitochondrial function and skeletal muscle oxidative capacity: significance for metabolic complications in cancer survivors', Metabolism: clinical and experimental, vol. 103, pp. 154025, http://dx.doi.org/10.1016/j.metabol.2019.154025
    Journal articles | 2020
    Professor Adelle Coster
    Field JH; Summerhayes GR; Luu S; Coster ACF; Ford A; Mandui H; Fullagar R; Hayes E; Leavesley M; Lovave M; Kealhofer L, 2020, 'Functional studies of flaked and ground stone artefacts reveal starchy tree nut and root exploitation in mid-Holocene highland New Guinea', Holocene, vol. 30, pp. 1360 - 1374, http://dx.doi.org/10.1177/0959683620919983
    Journal articles | 2020
    Professor Adelle Coster
    Shaw B; Field JH; Summerhayes GR; Coxe S; Coster ACF; Ford A; Haro J; Arifeae H; Hull E; Jacobsen G; Fullagar R; Hayes E; Kealhofer L, 2020, 'Emergence of a Neolithic in highland New Guinea by 5000 to 4000 years ago', Science Advances, vol. 6, http://dx.doi.org/10.1126/sciadv.aay4573
    Journal articles | 2020
    Professor Adelle Coster
    Gray CW; Coster ACF, 2020, 'From insulin to Akt: Time delays and dominant processes', Journal of Theoretical Biology, vol. 507, http://dx.doi.org/10.1016/j.jtbi.2020.110454
    Journal articles | 2020
    Professor Adelle Coster
    Gaffney D; Greig K; Stoddart D; Tromp M; Field JH; Luu S; Coster ACF; Russell T; Mandui H; Summerhayes GR, 2020, 'Tropical Foodways and Exchange along the Coastal Margin of Northeastern New Guinea', Journal of Field Archaeology, pp. 498 - 511, http://dx.doi.org/10.1080/00934690.2020.1786285
    Journal articles | 2019
    Professor Adelle Coster
    Gray CW; Coster ACF, 2019, 'Crosstalk in transition: the translocation of Akt', Journal of Mathematical Biology, vol. 78, pp. 919 - 942, http://dx.doi.org/10.1007/s00285-018-1297-8
    Journal articles | 2019
    Professor Adelle Coster
    Tang A; Coster ACE; Tonks KT; Heilbronn LK; Pocock N; Purtell L; Govendir M; Blythe J; Zhang J; Xu A; Chisholm DJ; Johnson NA; Greenfield JR; Samocha-Bonet D, 2019, 'Longitudinal Changes in Insulin Resistance in Normal Weight, Overweight and Obese Individuals', JOURNAL OF CLINICAL MEDICINE, vol. 8, http://dx.doi.org/10.3390/jcm8050623
    Journal articles | 2019
    Professor Adelle Coster
    Owen T; Field J; Luu S; Kokatha Aboriginal People ; Stephenson B; Coster ACF, 2019, 'Ancient starch analysis of grinding stones from Kokatha Country, South Australia', Journal of Archaeological Science: Reports, vol. 23, pp. 178 - 188, http://dx.doi.org/10.1016/j.jasrep.2018.10.023
    Journal articles | 2018
    Professor Adelle Coster
    Janco M; Böcking T; He S; Coster ACF, 2018, 'Interactions of tropomyosin Tpm1.1 on a single actin filament: A method for extraction and processing of high resolution TIRF microscopy data', PLoS ONE, vol. 13, pp. e0208586, http://dx.doi.org/10.1371/journal.pone.0208586
    Journal articles | 2018
    Professor Adelle Coster
    Jennera A; Yun C-O; Yoon A; Coster A; Kim P, 2018, 'Modelling Combined Virotherapy and Immunotherapy: Strengthening the Antitumour Immune Response Mediated by IL-12 and GM-CSF Expression', Letters in Biomathematics, vol. 5, http://dx.doi.org/10.30707/lib5.2jennera
    Journal articles | 2018
    Professor Adelle Coster
    Jenner AL; Coster ACF; Kim PS; Frascoli F, 2018, 'Treating cancerous cells with viruses: insights from a minimal model for oncolytic virotherapy', Letters in Biomathematics, vol. 5, pp. S117 - S136, http://dx.doi.org/10.1080/23737867.2018.1440977
    Journal articles | 2018
    Professor Adelle Coster
    Jenner AL; Yun CO; Yoon A; Coster ACF; Kim PS, 2018, 'Modelling combined virotherapy and immunotherapy: strengthening the antitumour immune response mediated by IL-12 and GM-CSF expression', Letters in Biomathematics, vol. 5, pp. S99 - S116, http://dx.doi.org/10.1080/23737867.2018.1438216
    Journal articles | 2018
    Professor Adelle Coster
    Jenner AL; Yun CO; Kim PS; Coster ACF, 2018, 'Mathematical Modelling of the Interaction Between Cancer Cells and an Oncolytic Virus: Insights into the Effects of Treatment Protocols', Bulletin of Mathematical Biology, vol. 80, pp. 1615 - 1629, http://dx.doi.org/10.1007/s11538-018-0424-4
    Journal articles | 2018
    Professor Adelle Coster
    Lape P; Peterson E; Tanudirjo D; Shiung CC; Lee GA; Field J; Coster A, 2018, 'New data from an open Neolithic site in Eastern Indonesia', Asian Perspectives, vol. 57, pp. 222 - 243, http://dx.doi.org/10.1353/asi.2018.0015
    Journal articles | 2018
    Professor Adelle Coster
    Jenner A; Yun CO; Yoon A; Kim PS; Coster ACF, 2018, 'Modelling heterogeneity in viral-tumour dynamics: The effects of gene-attenuation on viral characteristics', Journal of Theoretical Biology, vol. 454, pp. 41 - 52, http://dx.doi.org/10.1016/j.jtbi.2018.05.030
    Journal articles | 2018
    Professor Adelle Coster
    Jenner A; Coster A; Kim P; Frascoli F, 2018, 'Treating Cancerous Cells with Viruses: Insights from Aminimal Model for Oncolytic Virotherapy', Letters in Biomathematics, vol. 5, http://dx.doi.org/10.30707/lib5.2jenner
    Journal articles | 2017
    Professor Adelle Coster
    Montgomery MK; Brown SHJ; Mitchell TW; Coster ACF; Cooney GJ; Turner N, 2017, 'Association of muscle lipidomic profile with high-fat diet-induced insulin resistance across five mouse strains', Scientific Reports, vol. 7, http://dx.doi.org/10.1038/s41598-017-14214-1
    Journal articles | 2016
    Professor Adelle Coster
    Al-Zyoud WA; Hynson RMG; Ganuelas LA; Coster ACF; Duff AP; Baker MAB; Stewart AG; Giannoulatou E; Ho JWK; Gaus K; Liu D; Lee LK; Böcking T, 2016, 'Binding of transcription factor GabR to DNA requires recognition of DNA shape at a location distinct from its cognate binding site', Nucleic Acids Research, vol. 44, pp. 1411 - 1420, http://dx.doi.org/10.1093/nar/gkv1466
    Journal articles | 2016
    Professor Adelle Coster
    Minard AY; Wong MKL; Chaudhuri R; Tan SX; Humphrey SJ; Parker BL; Yang JY; Laybutt DR; Cooney GJ; Coster ACF; Stöckli J; James DE, 2016, 'Hyperactivation of the insulin signaling pathway improves intracellular proteostasis by coordinately up-regulating the proteostatic machinery in adipocytes', Journal of Biological Chemistry, vol. 291, pp. 25629 - 25640, http://dx.doi.org/10.1074/jbc.M116.741140
    Journal articles | 2016
    Professor Adelle Coster
    Brewer PD; Habtemichael EN; Romenskaia I; Coster ACF; Mastick CC, 2016, 'Rab14 limits the sorting of Glut4 from endosomes into insulin-sensitive regulated secretory compartments in adipocytes', Biochemical Journal, vol. 473, pp. 1315 - 1327, http://dx.doi.org/10.1042/BCJ20160020
    Journal articles | 2016
    Professor Adelle Coster
    Brewer PD; Habtemichael EN; Romenskaia I; Mastick CC; Coster ACF, 2016, 'Glut4 is sorted from a Rab10 GTPase-independent constitutive recycling pathway into a highly insulinresponsive Rab10 GTPase-dependent sequestration pathway after adipocyte differentiation', Journal of Biological Chemistry, vol. 291, pp. 773 - 789, http://dx.doi.org/10.1074/jbc.M115.694919
    Journal articles | 2016
    Professor Adelle Coster
    Tonks KT; Coster AC; Christopher MJ; Chaudhuri R; Xu A; Gagnon-Bartsch J; Chisholm DJ; James DE; Meikle PJ; Greenfield JR; Samocha-Bonet D, 2016, 'Skeletal muscle and plasma lipidomic signatures of insulin resistance and overweight/obesity in humans', Obesity, vol. 24, pp. 908 - 916, http://dx.doi.org/10.1002/oby.21448
    Journal articles | 2016
    Professor Adelle Coster
    Gray CW; Coster ACF, 2016, 'The Akt switch model: Is location sufficient?', Journal of Theoretical Biology, vol. 398, pp. 103 - 111, http://dx.doi.org/10.1016/j.jtbi.2016.03.005
    Journal articles | 2016
    Professor Adelle Coster
    Montgomery MK; Brown SHJ; Lim XY; Fiveash CE; Osborne B; Bentley NL; Braude JP; Mitchell TW; Coster ACF; Don AS; Cooney GJ; Schmitz-Peiffer C; Turner N, 2016, 'Regulation of glucose homeostasis and insulin action by ceramide acyl-chain length: A beneficial role for very long-chain sphingolipid species', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, vol. 1861, pp. 1828 - 1839, http://dx.doi.org/10.1016/j.bbalip.2016.08.016
    Journal articles | 2016
    Professor Adelle Coster
    Nicovich PR; Janco M; Sobey T; Gajwani M; Obeidy P; Whan R; Gaus K; Gunning PW; Coster ACF; Böcking T, 2016, 'Effect of surface chemistry on tropomyosin binding to actin filaments on surfaces', Cytoskeleton, vol. 73, pp. 729 - 738, http://dx.doi.org/10.1002/cm.21342
    Journal articles | 2016
    Professor Adelle Coster
    Janco M; Bonello TT; Byun A; Coster ACF; Lebhar H; Dedova I; Gunning PW; Böcking T, 2016, 'The impact of tropomyosins on actin filament assembly is isoform specific', BioArchitecture, vol. 6, pp. 61 - 75, http://dx.doi.org/10.1080/19490992.2016.1201619
    Journal articles | 2016
    Professor Adelle Coster
    Field JH; Kealhofer L; Cosgrove R; Coster ACF, 2016, 'Human-environment dynamics during the Holocene in the Australian Wet Tropics of NE Queensland: A starch and phytolith study', Journal of Anthropological Archaeology, vol. 44, pp. 216 - 234, http://dx.doi.org/10.1016/j.jaa.2016.07.007
    Journal articles | 2015
    Professor Adelle Coster
    Williams RS; Heilbronn LK; Chen DL; Coster A; Greenfield JR; Samocha-Bonet D, 2015, 'Dietary acid load, metabolic acidosis and insulin resistance - Lessons from cross-sectional and overfeeding studies in humans', Clinical Nutrition, vol. 35, pp. 1084 - 1090, http://dx.doi.org/10.1016/j.clnu.2015.08.002
    Journal articles | 2015
    Professor Adelle Coster
    Tan SX; Fisher-Wellman KH; Fazakerley DJ; Ng Y; Pant H; Li J; Meoli CC; Coster ACF; Stöckli J; James DE, 2015, 'Selective insulin resistance in adipocytes', Journal of Biological Chemistry, vol. 290, pp. 11337 - 11348, http://dx.doi.org/10.1074/jbc.M114.623686
    Journal articles | 2015
    Professor Adelle Coster
    Coster AC; Field JH, 2015, 'What starch grain is that? - A geometric morphometric approach to determining plant species origin', Journal of Archaeological Science, vol. 58, pp. 9 - 25, http://dx.doi.org/10.1016/j.jas.2015.03.014
    Journal articles | 2015
    Professor Adelle Coster
    Gray CW; Coster A, 2015, 'A receptor state space model of insulin signalling system in glucose transport', Mathematical Medicine and Biology, vol. First published online: February 10, 2015, pp. 1 - 17, http://dx.doi.org/10.1093/imammb/dqv003
    Journal articles | 2014
    Professor Adelle Coster
    Samocha-Bonet D; Chisholm DJ; Gribble FM; Coster ACF; Carpenter KH; Jones GRD; Holst JJ; Greenfield JR, 2014, 'Glycemic effects and safety of L-glutamine supplementation with or without sitagliptin in type 2 diabetes patients-a randomized study', PLoS ONE, vol. 9, http://dx.doi.org/10.1371/journal.pone.0113366
    Journal articles | 2014
    Professor Adelle Coster
    Brewer PD; Habtemichael EN; Romenskaia I; Mastick CC; Coster ACF, 2014, 'Insulin-regulated Glut4 translocation: Membrane protein trafficking with six distinctive steps', Journal of Biological Chemistry, vol. 289, pp. 17280 - 17298, http://dx.doi.org/10.1074/jbc.M114.555714
    Journal articles | 2014
    Professor Adelle Coster
    Polwiang S; Coster A, 2014, 'Coupling and synchronization of oscillators in the sinoatrial node', Experimental and Clinical Cardiology, vol. 20, pp. 1788 - 1797
    Journal articles | 2013
    Professor Adelle Coster
    Heilbronn LK; Coster ACF; Campbell LV; Greenfield JR; Lange K; Christopher MJ; Meikle PJ; Samocha-Bonet D, 2013, 'The effect of short-term overfeeding on serum lipids in healthy humans', Obesity, vol. 21, http://dx.doi.org/10.1002/oby.20508
    Journal articles | 2013
    Professor Adelle Coster
    Tonks KT; Ng Y; Miller S; Coster ACF; Samocha-Bonet D; Iseli TJ; Xu A; Patrick E; Yang JYH; Junutula JR; Modrusan Z; Kolumam G; Stöckli J; Chisholm DJ; James DE; Greenfield JR, 2013, 'Impaired Akt phosphorylation in insulin-resistant human muscle is accompanied by selective and heterogeneous downstream defects', Diabetologia, vol. 56, pp. 875 - 885, http://dx.doi.org/10.1007/s00125-012-2811-y
    Journal articles | 2011
    Professor Adelle Coster
    Tonks KT; Ng Y; Miller S; Coster ACF; Samocha-Bonet D; Iseli TJ; Xu A; Stöckli J; Chisholm DJ; James DE; Greenfield JR, 2011, 'Obese, yet insulin sensitive humans', Obesity Research & Clinical Practice, vol. 5, pp. 13 - 13, http://dx.doi.org/10.1016/j.orcp.2011.08.079
    Journal articles | 2010
    Professor Adelle Coster
    Ng Y; Ramm G; Burchfield JG; Coster A; Stockli J; James DE, 2010, 'Cluster analysis of insulin action adipocytes reveals a key role for Akt at the plasma membrane', The Journal of Biological Chemistry, vol. 285, pp. 2245 - 2257, http://dx.doi.org/10.1074/jbc.M109.060236
    Journal articles | 2010
    Professor Adelle Coster
    Fazakerley DJ; Holman GD; Marley A; Stockli J; James DE; Coster A, 2010, 'Kinetic evidence for unique regulation of GLUT4 trafficking by insulin and AMPK activators in L6 myotubes', The Journal of Biological Chemistry, vol. 285, pp. 1653 - 1660, http://dx.doi.org/10.1074/jbc.M109.051185
    Journal articles | 2010
    Professor Adelle Coster
    Stockli J; Fazakerley DJ; Coster A; Holman GD; James DE, 2010, 'Muscling in on GLUT4 kinetics', Communicative & Integrative Biology, vol. 3, pp. 260 - 262, http://dx.doi.org/10.4161/cib
    Journal articles | 2009
    Professor Adelle Coster
    Chilcott TC; Wong EL; Coster HG; Coster A; James M, 2009, 'Ionic double layer of atomically flat gold formed on mica templates', Electrochimica ACTA, vol. 54, pp. 3766 - 3774, http://dx.doi.org/10.1016/j.electacta.2009.01.069
    Journal articles | 2009
    Professor Adelle Coster
    Mele K; Burchfield JG; Lopez J; James DE; Hughes WE; Coster A; Vallotton P, 2009, 'TIRF microscopy software for automated vesicle fusion detection', American Biotechnology Laboratory, vol. 27, pp. 8 - 9
    Journal articles | 2006
    Professor Adelle Coster
    Chik DT; Coster A, 2006, 'Noise accelerates synchronization of coupled nonlinear oscillators', Physical Review E, vol. 74, pp. 041128, http://dx.doi.org/10.1103/PhysRevE.74.041128
    Journal articles | 2004
    Professor Adelle Coster
    Govers R; Coster A; James DD, 2004, 'Insulin increases cell surface GLUT4 levels by dose dependently discharging GLUT4 into a cell surface recycling pathway', Molecular and Cellular Biology, vol. 24, pp. 6456 - 6466, http://dx.doi.org/10.1128/MCB.24.14.6456-6466.2004
    Journal articles | 2004
    Professor Adelle Coster
    Coster A; Govers R; James DD, 2004, 'Insulin stimulates the entry of GLUT4 into the endosomal recycling pathway by a quantal mechanism', Traffic (Malden), vol. 5, pp. 763 - 771, http://dx.doi.org/10.1111/j.1600-0854.2004.00218.x
    Journal articles | 2004
    Professor Adelle Coster
    Mathie MJ; Celler BG; Lovell NH; Coster A, 2004, 'Classification of basic daily movements using a triaxial accelerometer', Medical and Biological Engineering and Computing, vol. 42, pp. 679 - 687, http://dx.doi.org/10.1007/BF02347551
    Journal articles | 2004
    Professor Adelle Coster
    Mathie MJ; Coster A; Lovell NH; Celler BG; Lord SR; Tiedemann A, 2004, 'A pilot study of long-term monitoring of human movements in the home using accelerometry', Journal of Telemedicine and Telecare, vol. 10, pp. 144 - 151, http://dx.doi.org/10.1258/135763304323070788
    Journal articles | 2004
    Professor Adelle Coster
    Mathie MJ; Coster A; Lovell NH, 2004, 'Accelerometry: providing an integrated, practical method for long-term, ambulatory monitoring of human movement', Physiological Measurement, vol. 25, pp. 1 - 20, http://dx.doi.org/10.1088/0967-3334/25/2/R01
    Journal articles | 2003
    Professor Adelle Coster
    Mathie MJ; Coster AC; Lovell NH; Celler BG, 2003, 'Detection of daily physical activities using a triaxial accelerometer', Medical and Biological Engineering and Computing, vol. 41, pp. 296 - 301, http://dx.doi.org/10.1007/BF02348434
    Journal articles | 2003
    Professor Adelle Coster
    Coster ACF; Celler BG, 2003, 'Phase response of model sinoatrial node cells', Annals of Biomedical Engineering, vol. 31, pp. 271 - 283, http://dx.doi.org/10.1114/1.1553455
    Journal articles | 2001
    Professor Adelle Coster
    Coster AC; Alstrom P, 2001, 'Expectation and conditioning', Physica A - Statistical Mechanics and Its Applications, vol. 290, pp. 251 - 267, http://dx.doi.org/10.1016/S0378-4371(00)00552-5
    Journal articles | 1996
    Professor Adelle Coster
    Coster HG; Chilcott TC; Coster AC, 1996, 'Impedance spectroscopy of interfaces, membranes and ultrastructures', Bioelectrochemistry and Bioenergetics, vol. 40, pp. 79 - 98, http://dx.doi.org/10.1016/0302-4598(96)05064-7
    Journal articles | 1996
    Professor Adelle Coster
    Coster ACF, 1996, 'On the ensemble properties of interacting neurons', PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY, vol. 65, pp. PG307 - PG307, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1996WE75300679&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
  • Conference Abstracts | 2015
    Professor Adelle Coster
    Obeidy P; Sobey TL; Pandzic E; Nicovich PR; Coster A; Gunning P; Boecking T, 2015, 'Actin Tropomyosin Assembly Intermediates', in BIOPHYSICAL JOURNAL., CELL PRESS, Vol. 108, pp. 298A - 298A, presented at AACR Special Conference on Advances in Pediatric Cancer Research, http://dx.doi.org/10.1016/j.bpj.2014.11.1619
    Conference Papers | 2014
    Professor Adelle Coster
    Brewer PD; Habtemichael EN; Romenskaia I; Coster A; Mastick C, 2014, 'Mapping Sites of Insulin Regulation in Glut4 Trafficking: Insulin Regulates Fusion, Sequestration into and Release from GSVs', in DIABETES, AMER DIABETES ASSOC, pp. A653 - A653, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000359481603424&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2013
    Professor Adelle Coster
    Brewer PD; Romenskaia I; Habtemichael EN; Coster A; Mastick CC, 2013, 'Identification of Regulatory Nodes in Glut4 Trafficking', in DIABETES, AMER DIABETES ASSOC, pp. A465 - A465, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209473602389&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2011
    Professor Adelle Coster
    Polwiang S; Coster A, 2011, 'The effect of gap junction conductance on synchronisation of sinoatrial node central cells', in AIP Conference Proceedings, volume 1371, American Institute of Physics, Toyama City, Japan, pp. 146 - 155, presented at 2011 International Symposium on Computational Models for Life Sciences, CMLS-11, Toyama City, Japan, 11 October 2011 - 13 October 2011, http://dx.doi.org/10.1063/1.3596637
    Conference Papers | 2010
    Professor Adelle Coster
    Polwiang S; Coster A, 2010, 'The Synchronization of Sinoatrial Node Cells: The Transition from Centre to Periphery', in Proceedings of the IASTED International Conference on Computational Bioscience, CompBio 2010, ACTA Press, Calgary, AB, Canada, pp. 581 - 586, presented at IASTED International Conference on Computational Bioscience, CompBio 2010, Cambridge, Massachusetts, USA, 01 November 2010 - 03 November 2010, http://dx.doi.org/10.2316/P.2010.728-022
    Conference Papers | 2009
    Professor Adelle Coster
    Mele K; Coster A; Burchfield JG; Lopez J; James DE; Hughes WE; Vallotton P, 2009, 'Automatic identification of fusion events in TIRF microscopy image sequences', in IEEE (ed.), IEEE 12th International Conference on Computer Vision Workshops, ICCV Workshops 2009, IEEE, Kyoto, pp. 578 - 584, presented at IEEE 12th International Conference on Computer Vision Workshops, Kyoto, 27 September 2009 - 04 October 2009, http://dx.doi.org/10.1109/ICCVW.2009.5457651
    Conference Papers | 2005
    Professor Adelle Coster
    Chik D; Coster A, 2005, 'Modelling cardiac dynamics with integral pulse frequency modulated units', in Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, pp. 933 - 935, http://dx.doi.org/10.1109/iembs.2005.1616568
    Conference Papers | 2003
    Professor Adelle Coster
    Mathie MJ; Coster A; Lovell NH; Celler BG; Wang L, 2003, 'Use of a Triaxial Accelerometer in Unsupervised Monitoring of Human Movement', in Proceedings of the World Congress on Medical Physics and Biomedical Engineering, World Congress on Medical Physics and Biomedical Engineering 2003, Sydney, Convention and Exhibition Centre, Sydney, Australia, presented at World Congress on Medical Physics and Biomedical Engineering 2003, Sydney, Convention and Exhibition Centre, Sydney, Australia, 24 August 2003 - 29 August 2003
    Conference Papers | 2003
    Professor Adelle Coster
    Mathie MJ; Coster A; Lovell NH; Celler BG, 2003, 'Design of a Study for Unsupervised Monitoring using a Triaxial Accelerometer', in Proceedings of the World Congress on Medical Physics and Biomedical Engineering, World Congress on Medical Physics and Biomedical Engineering 2003, Sydney, Convention and Exhibition Centre, Sydney, Australia, presented at World Congress on Medical Physics and Biomedical Engineering 2003, Sydney, Convention and Exhibition Centre, Sydney, Australia, 24 August 2003 - 29 August 2003
    Conference Papers | 2002
    Professor Adelle Coster
    Mathie MJ; Lovell NH; Coster AC; Celler BG, 2002, 'Determining activity using a triaxial accelerometer', in EMBS-BMES 2002 Joint Conference, Houston, Texas, pp. 2481 - 2482, presented at EMBS-BMES 2002 Joint Conference, Houston, Texas, 23 October 2002 - 26 October 2002
    Conference Papers | 2001
    Professor Adelle Coster
    Coster AC; Celler BG, 2001, 'Phase Response of Model Sinoatrial Node Cells - an Investigation of the Influence of Stimulus Parameters', in EMBC2001 23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Istanbul, Turkey, pp. 40 - 43, presented at EMBC2001 23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Istanbul, Turkey, 25 October 2001 - 28 October 2001
    Conference Papers | 2001
    Professor Adelle Coster
    Celler BG; Coster AC, 2001, 'The Memory Effect and Phase Response of Model Sinoatrial Node Cells', in EMBC2001 23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Istanbul, Turkey, pp. 36 - 39, presented at EMBC2001 23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Istanbul, Turkey, 25 October 2001 - 28 October 2001
    Theses / Dissertations | 1998
    Professor Adelle Coster
    Coster AC, 1998, Neural ensembles: A statistical mechanical exploration

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