Dr Alastair Stewart

Dr Alastair Stewart

Conjoint Senior Lecturer
Medicine & Health
School of Clinical Medicine
Location
405 Liverpool Street, Darlinghurst, NSW 2010
  • Book Chapters | 2020
    Sobti M; Ishmukhametov R; Stewart AG, 2020, 'ATP Synthase: Expression, Purification, and Function', in Methods in Molecular Biology, Springer US, pp. 73 - 84, http://dx.doi.org/10.1007/978-1-4939-9869-2_5
  • Journal articles | 2023
    Lau C; Flood E; Hunter M; Corbett K; Ng C; Bouwer J; Stewart A; Perozo E; Allen TW; Vandenberg J, 2023, 'Structural basis of rapid inactivation of HERG potassium channels', BIOPHYSICAL JOURNAL, 122, pp. 446A - 446A, http://dx.doi.org/10.1016/j.bpj.2022.11.2409
    Journal articles | 2023
    Rouet R; Henry JY; Johansen MD; Sobti M; Balachandran H; Langley DB; Walker GJ; Lenthall H; Jackson J; Ubiparipovic S; Mazigi O; Schofield P; Burnett DL; Brown SHJ; Martinello M; Hudson B; Gilroy N; Post JJ; Kelleher A; Jäck HM; Goodnow CC; Turville SG; Rawlinson WD; Bull RA; Stewart AG; Hansbro PM; Christ D, 2023, 'Broadly neutralizing SARS-CoV-2 antibodies through epitope-based selection from convalescent patients', Nature Communications, 14, pp. 687, http://dx.doi.org/10.1038/s41467-023-36295-5
    Journal articles | 2023
    Sobti M; Mead BJ; Stewart AG; Igreja C; Christie M, 2023, 'Molecular basis for GIGYF–TNRC6 complex assembly', RNA, 29, pp. 724 - 734, http://dx.doi.org/10.1261/rna.079596.123
    Journal articles | 2023
    Sobti M; Zeng YC; Walshe JL; Brown SHJ; Ishmukhametov R; Stewart AG, 2023, 'Changes within the central stalk of E. coli F1Fo ATP synthase observed after addition of ATP', Communications Biology, 6, pp. 26, http://dx.doi.org/10.1038/s42003-023-04414-z
    Journal articles | 2022
    Stewart AG; Sobti M; Ueno H; Noji H, 2022, 'The rotary catalytic cycle of a thermophilic F-1-ATPase', BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 1863, pp. 60 - 60, http://dx.doi.org/10.1016/j.bbabio.2022.148772
    Journal articles | 2021
    Burnett DL; Jackson KJL; Langley DB; Aggrawal A; Stella AO; Johansen MD; Balachandran H; Lenthall H; Rouet R; Walker G; Saunders BM; Singh M; Li H; Henry JY; Jackson J; Stewart AG; Witthauer F; Spence MA; Hansbro NG; Jackson C; Schofield P; Milthorpe C; Martinello M; Schulz SR; Roth E; Kelleher A; Emery S; Britton WJ; Rawlinson WD; Karl R; Schäfer S; Winkler TH; Brink R; Bull RA; Hansbro PM; Jäck HM; Turville S; Christ D; Goodnow CC, 2021, 'Immunizations with diverse sarbecovirus receptor-binding domains elicit SARS-CoV-2 neutralizing antibodies against a conserved site of vulnerability', Immunity, 54, pp. 2908 - 2921.e6, http://dx.doi.org/10.1016/j.immuni.2021.10.019
    Journal articles | 2021
    Chen I; Pant S; Wu Q; Cater RJ; Sobti M; Vandenberg RJ; Stewart A; Font J; Tajkhorshid E; Ryan RM, 2021, 'Glutamate Transporters (EAATS) Contain a Conserved Chloride Channel with Two Hydrophobic Gates', BIOPHYSICAL JOURNAL, 120, pp. 104A - 105A, http://dx.doi.org/10.1016/j.bpj.2020.11.846
    Journal articles | 2021
    Chen I; Pant S; Wu Q; Cater RJ; Sobti M; Vandenberg RJ; Stewart AG; Tajkhorshid E; Font J; Ryan RM, 2021, 'Glutamate transporters have a chloride channel with two hydrophobic gates', Nature, 591, pp. 327 - 331, http://dx.doi.org/10.1038/s41586-021-03240-9
    Journal articles | 2021
    Ngo T; Ilatovskiy AV; Stewart AG; Coleman JLJ; McRobb FM; Riek RP; Graham RM; Abagyan R; Kufareva I; Smith NJ, 2021, 'Retraction Note: Orphan receptor ligand discovery by pickpocketing pharmacological neighbors (Nature Chemical Biology, (2017), 13, 2, (235-242), 10.1038/nchembio.2266)', Nature Chemical Biology, 17, pp. 501, http://dx.doi.org/10.1038/s41589-021-00746-1
    Journal articles | 2021
    Pant S; Chen I; Wu Q; Cater R; Sobti M; Vandenberg RJ; Stewart AG; Font J; Ryan RM; Tajkhorshid E, 2021, 'A Novel Chloride Conducting Conformation in Human Glutamate Transporters', BIOPHYSICAL JOURNAL, 120, pp. 171A - 171A, http://dx.doi.org/10.1016/j.bpj.2020.11.1209
    Journal articles | 2021
    Rouet R; Mazigi O; Walker GJ; Langley DB; Sobti M; Schofield P; Lenthall H; Jackson J; Ubiparipovic S; Henry JY; Abayasingam A; Burnett D; Kelleher A; Brink R; Bull RA; Turville S; Stewart AG; Goodnow CC; Rawlinson WD; Christ D, 2021, 'Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1 antibodies', mAbs, 13, pp. 1922134, http://dx.doi.org/10.1080/19420862.2021.1922134
    Journal articles | 2021
    Sobti M; Mead BJ; Igreja C; Stewart AG; Christie M, 2021, 'Molecular basis for GIGYF-TNRC6 complex assembly in miRNA-mediated translational repression', , http://dx.doi.org/10.1101/2021.08.20.457040
    Journal articles | 2021
    Sobti M; Ueno H; Noji H; Stewart AG, 2021, 'The six steps of the complete F1-ATPase rotary catalytic cycle', Nature Communications, 12, pp. 4690, http://dx.doi.org/10.1038/s41467-021-25029-0
    Journal articles | 2021
    Zeng YC; Sobti M; Stewart AG, 2021, 'Structural analysis of the Sulfolobus solfataricus TF55β chaperonin by cryo-electron microscopy', Acta Crystallographica Section F: Structural Biology Communications, 77, pp. 79 - 84, http://dx.doi.org/10.1107/S2053230X21002223
    Journal articles | 2020
    Rouet R; Mazigi O; Walker G; Langley D; Sobti M; Schofield P; Lenthall H; Jackson J; Ubiparipovic S; Henry J; Abayasingam A; Burnett D; Kelleher A; Brink R; Bull R; Turville S; Stewart A; Goodnow C; Rawlinson W; Christ D, 2020, 'Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1 antibodies', , http://dx.doi.org/10.1101/2020.12.14.422791
    Journal articles | 2020
    Sobti M; Walshe J; Zeng Y; Ishmukhametov R; Stewart A, 2020, 'Subunit epsilon ofE. coliF1FoATP synthase attenuates enzyme activity by modulating central stalk flexibility', , http://dx.doi.org/10.1101/2020.09.30.320408
    Journal articles | 2020
    Sobti M; Walshe JL; Wu D; Ishmukhametov R; Zeng YC; Robinson CV; Berry RM; Stewart AG, 2020, 'Cryo-EM structures provide insight into how E. coli F1Fo ATP synthase accommodates symmetry mismatch', Nature Communications, 11, http://dx.doi.org/10.1038/s41467-020-16387-2
    Journal articles | 2020
    Zeng YC; Sobti M; Stewart A, 2020, 'Structural analysis of Sulfolobus solfataricus TF55β chaperonin in open and filamentous states', , http://dx.doi.org/10.1101/2020.01.13.905216
    Journal articles | 2019
    Sobti M; Ishmukhametov R; Bouwer JC; Ayer A; Suarna C; Smith NJ; Christie M; Stocker R; Duncan TM; Stewart AG, 2019, 'Cryo-EM reveals distinct conformations of E. coli ATP synthase on exposure to ATP', eLife, 8, http://dx.doi.org/10.7554/eLife.43864
    Journal articles | 2019
    Sobti M; Walshe J; Ishmukhametov R; Stewart A, 2019, 'Visualizing movements inE. coliF1FoATP synthase indicates how the F1and Fomotors are coupled', , http://dx.doi.org/10.1101/622084
    Journal articles | 2018
    Berger J; Berger S; Li M; Jacoby AS; Arner A; Bavi N; Stewart AG; Currie PD, 2018, 'In Vivo Function of the Chaperonin TRiC in α-Actin Folding during Sarcomere Assembly', Cell Reports, 22, pp. 313 - 322, http://dx.doi.org/10.1016/j.celrep.2017.12.069
    Journal articles | 2018
    Chorev DS; Baker LA; Wu D; Beilsten-Edmands V; Rouse SL; Zeev-Ben-Mordehai T; Jiko C; Samsudin F; Gerle C; Khalid S; Stewart AG; Matthews SJ; Grünewald K; Robinson CV, 2018, 'Protein assemblies ejected directly from native membranes yield complexes for mass spectrometry', Science, 362, pp. 829 - 834, http://dx.doi.org/10.1126/science.aau0976
    Journal articles | 2018
    Lau C; Hunter MJ; Stewart A; Perozo E; Vandenberg JI, 2018, 'Never at rest: insights into the conformational dynamics of ion channels from cryo-electron microscopy', Journal of Physiology, 596, pp. 1107 - 1119, http://dx.doi.org/10.1113/JP274888
    Journal articles | 2017
    Chaston JJ; Stewart AG; Christie M, 2017, 'Structural characterisation of TNRC6A nuclear localisation signal in complex with importin-alpha', PLoS ONE, 12, http://dx.doi.org/10.1371/journal.pone.0183587
    Journal articles | 2017
    Davies RB; Smits C; Wong ASW; Stock D; Christie M; Sandin S; Stewart AG, 2017, 'Cryo-EM analysis of a domain antibody bound rotary ATPase complex', Journal of Structural Biology, 197, pp. 350 - 353, http://dx.doi.org/10.1016/j.jsb.2017.01.002
    Journal articles | 2017
    Ngo T; Ilatovskiy AV; Stewart AG; Coleman JLJ; McRobb FM; Riek RP; Graham RM; Abagyan R; Kufareva I; Smith NJ, 2017, 'Orphan receptor ligand discovery by pickpocketing pharmacological neighbors', Nature Chemical Biology, 13, pp. 235 - 242, http://dx.doi.org/10.1038/nchembio.2266
    Journal articles | 2016
    Al-Zyoud WA; Hynson RMG; Ganuelas LA; Coster ACF; Duff AP; Baker MAB; Stewart AG; Giannoulatou E; Ho JWK; Gaus K; Liu D; Lee LK; Böcking T, 2016, 'Binding of transcription factor GabR to DNA requires recognition of DNA shape at a location distinct from its cognate binding site', Nucleic Acids Research, 44, pp. 1411 - 1420, http://dx.doi.org/10.1093/nar/gkv1466
    Journal articles | 2016
    Chaston JJ; Smits C; Aragão D; Wong ASW; Ahsan B; Sandin S; Molugu SK; Molugu SK; Bernal RA; Stock D; Stewart AG, 2016, 'Structural and Functional Insights into the Evolution and Stress Adaptation of Type II Chaperonins', Structure, 24, pp. 364 - 374, http://dx.doi.org/10.1016/j.str.2015.12.016
    Journal articles | 2016
    Christie M; Chang CW; Róna G; Smith KM; Stewart AG; Takeda AAS; Fontes MRM; Stewart M; Vértessy BG; Forwood JK; Kobe B, 2016, 'Structural Biology and Regulation of Protein Import into the Nucleus', Journal of Molecular Biology, 428, pp. 2060 - 2090, http://dx.doi.org/10.1016/j.jmb.2015.10.023
    Journal articles | 2016
    Christie M; Chang CW; Róna G; Smith KM; Stewart AG; Takeda AAS; Fontes MRM; Stewart M; Vértessy BG; Forwood JK; Kobe B, 2016, 'Structural Biology and Regulation of Protein Import into the Nucleus', Journal of molecular biology, 428, pp. 2060 - 2090, http://dx.doi.org/10.1016/j.jmb.2015.10.023
    Journal articles | 2016
    Sobti M; Smits C; Wong ASW; Ishmukhametov R; Stock D; Sandin S; Stewart AG, 2016, 'Cryo-EM structures of the autoinhibited E. coli ATP synthase in three rotational states', eLife, 5, http://dx.doi.org/10.7554/eLife.21598
    Journal articles | 2014
    Stewart AG; Laming EM; Sobti M; Stock D, 2014, 'Rotary ATPases-dynamic molecular machines', Current Opinion in Structural Biology, 25, pp. 40 - 48, http://dx.doi.org/10.1016/j.sbi.2013.11.013
    Journal articles | 2014
    Stewart AG, 2014, 'The molecular v brake', Journal of Molecular Biology, 426, pp. 273 - 274, http://dx.doi.org/10.1016/j.jmb.2013.10.003
    Journal articles | 2014
    Zhou M; Politis A; Davies RB; Liko I; Wu KJ; Stewart AG; Stock D; Robinson CV, 2014, 'Ion mobility-mass spectrometry of a rotary ATPase reveals ATP-induced reduction in conformational flexibility', Nature Chemistry, 6, pp. 208 - 215, http://dx.doi.org/10.1038/nchem.1868
    Journal articles | 2013
    Stewart AG; Sobti M; Harvey RP; Stock D, 2013, 'Rotary ATPases: models, machine elements and technical specifications.', Bioarchitecture, 3, pp. 2 - 12, http://dx.doi.org/10.4161/bioa.23301
    Journal articles | 2012
    Stewart A; Lee L; Donohoe M; Chaston J; Stock D, 2012, 'The dynamic stator stalk of rotary ATPases', PROTEIN SCIENCE, 21, pp. 73 - 73, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000307019800060&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 2012
    Stewart AG; Lee LK; Donohoe M; Chaston JJ; Stock D, 2012, 'The dynamic stator stalk of rotary ATPases', Nature communications, 3, http://dx.doi.org/10.1038/ncomms1693
    Journal articles | 2012
    Stock D; Stewart GS, 2012, 'Priming a Molecular Motor for Disassembly', Structure, 20, pp. 1799 - 1800, http://dx.doi.org/10.1016/j.str.2012.10.003
    Journal articles | 2010
    Lee LK; Stewart AG; Donohoe M; Bernal RA; Stock D, 2010, 'The Structure of the peripheral stalk of Thermus thermophilus H+-ATPase/Synthase', Nature Structural and Molecular Biology, 17, pp. 373 - 378, http://dx.doi.org/10.1038/nsmb.1761
  • Preprints | 2022
    Rouet R; Henry J; Johansen M; Sobti M; Balachandran H; Langley D; Walker G; Lenthall H; Jackson J; Ubiparipovic S; Mazigi O; Schofield P; Burnett D; Brown S; Martinello M; Hudson B; Gilroy N; Post J; Kelleher A; Jäck H-M; Goodnow C; Turville S; Rawlinson W; Bull R; Stewart A; Hansbro P; Christ D, 2022, Broadly neutralizing SARS-CoV-2 antibodies through epitope-based selection from convalescent patients, , http://dx.doi.org/10.1101/2022.10.19.512954
    Preprints | 2021
    Vandenberg J; Lau C; Flood E; Hunter M; Ng C-A; Bouwer J; Stewart A; Perozo E; Allen T, 2021, Structural Basis for Rapid Voltage Dependent Inactivation of HERG Potassium Channels, , http://dx.doi.org/10.21203/rs.3.rs-1105661/v1
    Preprints | 2020
    Chen I; Pant S; Wu Q; Cater R; Sobti M; Vandenberg R; Stewart AG; Tajkhorshid E; Font J; Ryan R, 2020, Glutamate transporters contain a conserved chloride channel with two hydrophobic gates, , http://dx.doi.org/10.1101/2020.05.25.115360
    Preprints | 2020
    Sobti M; Ueno H; Noji H; Stewart AG, 2020, The six steps of the F1-ATPase rotary catalytic cycle, , http://dx.doi.org/10.1101/2020.12.15.422962