Dr Angli Xue
Conjoint Associate Lecturer

Dr Angli Xue

2021 - PhD (Statistical Genetics), The University of Queensland - Australia

2015 - BSc (Agronomy), Zhejiang University - China            

 
Medicine & Health
School of Biomedical Sciences

Angli Xue is a Postdoc Scientist in Powell Lab at the Garvan Institute of Medical Research. He obtained his PhD in 2021 at The University of Queensland working with Prof. Jian Yang in the field of statistical genetics. During the PhD, he utilized statistical and computational methods to dissect the genetic architecture of human complex diseases, perform meta-analyses and integrate multi-omics data to identify associated gene loci and gene regulatory mechanisms. He conducted the largest genetic study of type 2 diabetes and highlighted three T2D-associated genes with plausible regulatory mechanisms where a genetic variant exerts an effect on T2D through epigenetic regulation of gene expression. He also co-developed a software tool (GSMR2) for evaluating the causal relationship between modifiable risk factors and complex diseases. He was awarded the DeLill Nasser Award for Professional Development in Genetics and the Chinese Scholarship Council Award for Outstanding Students Abroad in recognization of his PhD work. Before moving to Australia, he completed the BSc at Zhejiang University in 2015.

Angli's current research is focused on identifying the genetic control of gene expression variability at the single-cell level. To achieve this goal, he is developing novel statistical methods for single-cell eQTL mapping and applying them to the OneK1K cohort which contains gene expression profiles of ~1000 peripheral blood mononuclear cells (PBMCs) from ~1000 individuals. This work may help to understand how genetic variants contribute to the immune disease risk at a cellular level.

Angli is actively participating in scientific community service and serves as an early career reviewer in GENETICS. He was also an ad hoc reviewer for many journals including Nature Medicine, Nature Human Behavior, Nucleic Acids Research, G3, EBioMedicine, etc.

Location
384 Victoria Street Darlinghurst NSW 2010
  • Journal articles | 2022
    Xiu X; Zhang H; Xue A; Cooper DN; Yan L; Yang Y; Yang Y; Zhao H, 2022, 'Genetic evidence for a causal relationship between type 2 diabetes and peripheral artery disease in both Europeans and East Asians', BMC medicine, vol. 20, pp. 300, http://dx.doi.org/10.1186/s12916-022-02476-0
    Journal articles | 2022
    Zhang H; Xiu X; Xue A; Yang Y; Yang Y; Zhao H, 2022, 'Mendelian randomization study reveals a population-specific putative causal effect of type 2 diabetes in risk of cataract.', Int J Epidemiol, vol. 50, pp. 2024 - 2037, http://dx.doi.org/10.1093/ije/dyab175
    Journal articles | 2021
    Adolphe C; Xue A; Fard AT; Genovesi LA; Yang J; Wainwright BJ, 2021, 'Genetic and functional interaction network analysis reveals global enrichment of regulatory T cell genes influencing basal cell carcinoma susceptibility', Genome Medicine, vol. 13, http://dx.doi.org/10.1186/s13073-021-00827-9
    Journal articles | 2021
    Sun X; Xue A; Qi T; Chen D; Shi D; Wu Y; Zheng Z; Zeng J; Yang J, 2021, 'Tumor mutational burden is polygenic and genetically associated with complex traits and diseases', Cancer Research, vol. 81, pp. 1230 - 1239, http://dx.doi.org/10.1158/0008-5472.CAN-20-3459
    Journal articles | 2021
    Xue A; Jiang L; Zhu Z; Wray NR; Visscher PM; Zeng J; Yang J, 2021, 'Genome-wide analyses of behavioural traits are subject to bias by misreports and longitudinal changes', Nature Communications, vol. 12, http://dx.doi.org/10.1038/s41467-020-20237-6
    Journal articles | 2021
    Xue A; Jiang L; Zhu Z; Wray NR; Visscher PM; Zeng J; Yang J, 2021, 'Publisher Correction: Genome-wide analyses of behavioural traits are subject to bias by misreports and longitudinal changes (Nature Communications, (2021), 12, 1, (20211), 10.1038/s41467-020-20237-6)', Nature Communications, vol. 12, http://dx.doi.org/10.1038/s41467-021-21294-1
    Journal articles | 2021
    Zeng J; Xue A; Jiang L; Lloyd-Jones LR; Wu Y; Wang H; Zheng Z; Yengo L; Kemper KE; Goddard ME; Wray NR; Visscher PM; Yang J, 2021, 'Widespread signatures of natural selection across human complex traits and functional genomic categories', Nature Communications, vol. 12, http://dx.doi.org/10.1038/s41467-021-21446-3
    Journal articles | 2021
    Zhang H; Xiu X; Xue A; Yang Y; Yang Y; Zhao H, 2021, 'Mendelian randomization study reveals a population-specific putative causal effect of type 2 diabetes in risk of cataract', International Journal of Epidemiology, vol. 50, pp. 2024 - 2037, http://dx.doi.org/10.1093/ije/dyab175
    Journal articles | 2020
    Revez JA; Lin T; Qiao Z; Xue A; Holtz Y; Zhu Z; Zeng J; Wang H; Sidorenko J; Kemper KE; Vinkhuyzen AAE; Frater J; Eyles D; Burne THJ; Mitchell B; Martin NG; Zhu G; Visscher PM; Yang J; Wray NR; McGrath JJ, 2020, 'Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration', Nature Communications, vol. 11, http://dx.doi.org/10.1038/s41467-020-15421-7
    Journal articles | 2019
    Byrne EM; Ferreira MAR; Xue A; Lindström S; Jiang X; Yang J; Easton DF; Wray NR; Chenevix-Trench G, 2019, 'Is Schizophrenia a Risk Factor for Breast Cancer?-Evidence from Genetic Data', Schizophrenia Bulletin, vol. 45, pp. 1251 - 1256, http://dx.doi.org/10.1093/schbul/sby162
    Journal articles | 2019
    Nalls MA; Blauwendraat C; Vallerga CL; Heilbron K; Bandres-Ciga S; Chang D; Tan M; Kia DA; Noyce AJ; Xue A; Bras J; Young E; von Coelln R; Simón-Sánchez J; Schulte C; Sharma M; Krohn L; Pihlstrøm L; Siitonen A; Iwaki H; Leonard H; Faghri F; Gibbs JR; Hernandez DG; Scholz SW; Botia JA; Martinez M; Corvol JC; Lesage S; Jankovic J; Shulman LM; Sutherland M; Tienari P; Majamaa K; Toft M; Andreassen OA; Bangale T; Brice A; Yang J; Gan-Or Z; Gasser T; Heutink P; Shulman JM; Wood NW; Hinds DA; Hardy JA; Morris HR; Gratten J; Visscher PM; Graham RR; Singleton AB; Adarmes-Gómez AD; Aguilar M; Aitkulova A; Akhmetzhanov V; Alcalay RN; Alvarez I; Alvarez V; Barrero FJ; Bergareche Yarza JA; Bernal-Bernal I; Billingsley K; Blazquez M; Bonilla-Toribio M; Boungiorno MT; Brockmann K; Bubb V; Buiza-Rueda D; Cámara A; Carrillo F; Carrión-Claro M; Cerdan D; Chelban V; Clarimón J; Clarke C; Compta Y; Cookson MR; Craig DW; Danjou F; Diez-Fairen M; Dols-Icardo O; Duarte J; Duran R; Escamilla-Sevilla F; Escott-Price V; Ezquerra M; Feliz C; Fernández M; Fernández-Santiago R; Finkbeiner S; Foltynie T; Garcia C; García-Ruiz P; Gomez Heredia MJ; Gómez-Garre P; González MM; Gonzalez-Aramburu I; Guelfi S; Guerreiro R, 2019, 'Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies', The Lancet Neurology, vol. 18, pp. 1091 - 1102, http://dx.doi.org/10.1016/S1474-4422(19)30320-5
    Journal articles | 2019
    Noyce AJ; Bandres-Ciga S; Kim J; Heilbron K; Kia D; Hemani G; Xue A; Lawlor DA; Smith GD; Duran R; Gan-Or Z; Blauwendraat C; Gibbs JR; Hinds DA; Yang J; Visscher P; Cuzick J; Morris H; Hardy J; Wood NW; Nalls MA; Singleton AB, 2019, 'The Parkinson's Disease Mendelian Randomization Research Portal', Movement Disorders, vol. 34, pp. 1864 - 1872, http://dx.doi.org/10.1002/mds.27873
    Journal articles | 2019
    Reynolds RH; Botía J; Nalls MA; Noyce AJ; Nicolas A; Cookson MR; Bandres-Ciga S; Gibbs JR; Hernandez DG; Singleton AB; Reed X; Leonard H; Blauwendraat C; Faghri F; Bras J; Guerreiro R; Tucci A; Kia DA; Houlden H; Plun-Favreau H; Mok KY; Wood NW; Lovering R; R’Bibo L; Rizig M; Chelban V; Trabzuni D; Tan M; Morris HR; Middlehurst B; Quinn J; Billingsley K; Holmans P; Kinghorn KJ; Lewis P; Escott-Price V; Williams N; Foltynie T; Brice A; Danjou F; Lesage S; Corvol JC; Martinez M; Giri A; Schulte C; Brockmann K; Simón-Sánchez J; Heutink P; Gasser T; Rizzu P; Sharma M; Shulman JM; Robak L; Lubbe S; Mencacci NE; Finkbeiner S; Lungu C; Scholz SW; Gan-Or Z; Rouleau GA; Krohan L; van Hilten JJ; Marinus J; Adarmes-Gómez AD; Bernal-Bernal I; Bonilla-Toribio M; Buiza-Rueda D; Carrillo F; Carrión-Claro M; Mir P; Gómez-Garre P; Jesús S; Labrador-Espinosa MA; Macias D; Vargas-González L; Méndez-del-Barrio C; Periñán-Tocino T; Tejera-Parrado C; Diez-Fairen M; Aguilar M; Alvarez I; Boungiorno MT; Carcel M; Pastor P; Tartari JP; Alvarez V; González MM; Blazquez M; Garcia C; Suarez-Sanmartin E; Barrero FJ; Rezola EM; Yarza JAB; Pagola AG; de Munain Arregui AL; Ruiz-Martínez J; Cerdan D; Duarte J; Clarimón J; Dols-Icardo O, 2019, 'Moving beyond neurons: the role of cell type-specific gene regulation in Parkinson’s disease heritability', npj Parkinson's Disease, vol. 5, http://dx.doi.org/10.1038/s41531-019-0076-6
    Journal articles | 2019
    Wang H; Zhang F; Zeng J; Wu Y; Kemper KE; Xue A; Zhang M; Powell JE; Goddard ME; Wray NR; Visscher PM; McRae AF; Yang J, 2019, 'Genotype-by-environment interactions inferred from genetic effects on phenotypic variability in the UK Biobank', Science Advances, vol. 5, http://dx.doi.org/10.1126/sciadv.aaw3538
    Journal articles | 2018
    Qi T; Wu Y; Zeng J; Zhang F; Xue A; Jiang L; Zhu Z; Kemper K; Yengo L; Zheng Z; Agbessi M; Ahsan H; Alves I; Andiappan A; Awadalla P; Battle A; Beutner F; Jan Bonder M; Boomsma D; Christiansen M; Claringbould A; Deelen P; Esko T; Favé MJ; Franke L; Frayling T; Gharib S; Gibson G; Hemani G; Jansen R; Kähönen M; Kalnapenkis A; Kasela S; Kettunen J; Kim Y; Kirsten H; Kovacs P; Krohn K; Kronberg-Guzman J; Kukushkina V; Kutalik Z; Lee B; Lehtimäki T; Loeffler M; Marigorta UM; Metspalu A; Milani L; Müller-Nurasyid M; Nauck M; Nivard M; Penninx B; Perola M; Pervjakova N; Pierce B; Powell J; Prokisch H; Psaty B; Raitakari O; Ring S; Ripatti S; Rotzschke O; Ruëger S; Saha A; Scholz M; Schramm K; Seppälä I; Stumvoll M; Sullivan P; Teumer A; Thiery J; Tong L; Tönjes A; Van Dongen J; Van Meurs J; Verlouw J; Völker U; Võsa U; Yaghootkar H; Zeng B; Marioni RE; Montgomery GW; Deary IJ; Wray NR; Visscher PM; McRae AF; Yang J, 2018, 'Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood', Nature Communications, vol. 9, http://dx.doi.org/10.1038/s41467-018-04558-1
    Journal articles | 2018
    Xue A; Wu Y; Zhu Z; Zhang F; Kemper KE; Zheng Z; Yengo L; Lloyd-Jones LR; Sidorenko J; Wu Y; Agbessi M; Ahsan H; Alves I; Andiappan A; Awadalla P; Battle A; Beutner F; Bonder MJ; Boomsma D; Christiansen M; Claringbould A; Deelen P; Esko T; Favé MJ; Franke L; Frayling T; Gharib S; Gibson G; Hemani G; Jansen R; Kähönen M; Kalnapenkis A; Kasela S; Kettunen J; Kim Y; Kirsten H; Kovacs P; Krohn K; Kronberg-Guzman J; Kukushkina V; Kutalik Z; Lee B; Lehtimäki T; Loeffler M; Marigorta UM; Metspalu A; Milani L; Müller-Nurasyid M; Nauck M; Nivard M; Penninx B; Perola M; Pervjakova N; Pierce B; Powell J; Prokisch H; Psaty B; Raitakari O; Ring S; Ripatti S; Rotzschke O; Ruëger S; Saha A; Scholz M; Schramm K; Seppälä I; Stumvoll M; Sullivan P; Teumer A; Thiery J; Tong L; Tönjes A; van Dongen J; van Meurs J; Verlouw J; Völker U; Võsa U; Yaghootkar H; Zeng B; McRae AF; Visscher PM; Zeng J; Yang J, 2018, 'Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes', Nature Communications, vol. 9, http://dx.doi.org/10.1038/s41467-018-04951-w
    Journal articles | 2018
    Zeng J; De Vlaming R; Wu Y; Robinson MR; Lloyd-Jones LR; Yengo L; Yap CX; Xue A; Sidorenko J; McRae AF; Powell JE; Montgomery GW; Metspalu A; Esko T; Gibson G; Wray NR; Visscher PM; Yang J, 2018, 'Signatures of negative selection in the genetic architecture of human complex traits', Nature Genetics, vol. 50, pp. 746 - 753, http://dx.doi.org/10.1038/s41588-018-0101-4
    Journal articles | 2017
    Mei Y; Yu J; Xue A; Fan S; Song M; Pang C; Pei W; Yu S; Zhu J, 2017, 'Dissecting genetic network of fruit branch traits in upland cotton by association mapping using SSR markers', PLoS ONE, vol. 12, http://dx.doi.org/10.1371/journal.pone.0162815
    Journal articles | 2017
    Xue A; Wang H; Zhu J, 2017, 'Dissecting genetic architecture of startle response in Drosophila melanogaster using multi-omics information', Scientific Reports, vol. 7, http://dx.doi.org/10.1038/s41598-017-11676-1
    Journal articles | 2014
    Wang J; Ding K; Chen Y; Zhang L; Liu Z; Xue A; Gu W; Yang X; Li X; Huang J; Xing C; Cao Y; Chen M, 2014, 'Detection of thrombin with an Aptamer-based macromolecule biosensor using bacterial ghost system', ACS Synthetic Biology, vol. 3, pp. 963 - 965, http://dx.doi.org/10.1021/sb500018f
  • Preprints | 2020
    Xue A; Jiang L; Zhu Z; Wray NR; Visscher PM; Zeng J; Yang J, 2020, Genome-wide analyses of behavioural traits biased by misreports and longitudinal changes, http://dx.doi.org/10.1101/2020.06.15.20131284
    Preprints | 2019
    Cheng F-F; Zhuang Y-Y; Wen X-R; Xue A; Yang J; Jin Z-B, 2019, Towards the identification of causal genes for age-related macular degeneration, http://dx.doi.org/10.1101/778613
    Preprints | 2019
    Noyce AJ; Bandres-Ciga S; Kim J; Heilbron K; Kia D; Hemani G; Xue A; Lawlor DA; Smith GD; Duran R; Gan-Or Z; Blauwendraat C; Gibbs JR; Hinds DA; Yang J; Visscher P; Cuzick J; Morris H; Hardy J; Wood NW; Nalls MA; Singleton AB, 2019, The Parkinson’s Disease Mendelian Randomization Research Portal, http://dx.doi.org/10.1101/604033
    Preprints | 2019
    Revez JA; Lin T; Qiao Z; Xue A; Holtz Y; Zhu Z; Zeng J; Wang H; Sidorenko J; Kemper KE; Vinkhuyzen AAE; Frater J; Eyles D; Burne THJ; Mitchell B; Martin NG; Zhu G; Visscher PM; Yang J; Wray NR; McGrath JJ, 2019, Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration, http://dx.doi.org/10.1101/860767
    Preprints | 2019
    Wang H; Zhang F; Zeng J; Wu Y; Kemper KE; Xue A; Zhang M; Powell JE; Goddard ME; Wray NR; Visscher PM; McRae AF; Yang J, 2019, Genotype-by-environment interactions inferred from genetic effects on phenotypic variability in the UK Biobank, http://dx.doi.org/10.1101/519538
    Preprints | 2019
    Zeng J; Xue A; Jiang L; Lloyd-Jones LR; Wu Y; Wang H; Zheng Z; Yengo L; Kemper KE; Goddard ME; Wray NR; Visscher PM; Yang J, 2019, Bayesian analysis of GWAS summary data reveals differential signatures of natural selection across human complex traits and functional genomic categories, http://dx.doi.org/10.1101/752527
    Preprints | 2018
    Nalls MA; Blauwendraat C; Vallerga CL; Heilbron K; Bandres-Ciga S; Chang D; Tan M; Kia DA; Noyce AJ; Xue A; Bras J; Young E; von Coelln R; Simón-Sánchez J; Schulte C; Sharma M; Krohn L; Pihlstrom L; Siitonen A; Iwaki H; Leonard H; Faghri F; Raphael Gibbs J; Hernandez DG; Scholz SW; Botia JA; Martinez M; Corvol J-C; Lesage S; Jankovic J; Shulman LM; Sutherland M; Tienari P; Majamaa K; Toft M; Andreassen OA; Bangale T; Brice A; Yang J; Gan-Or Z; Gasser T; Heutink P; Shulman JM; Wood N; Hinds DA; Hardy JA; Morris HR; Gratten J; Visscher PM; Graham RR; Singleton AB, 2018, Expanding Parkinson’s disease genetics: novel risk loci, genomic context, causal insights and heritable risk, http://dx.doi.org/10.1101/388165
    Preprints | 2018
    Qi T; Wu Y; Zeng J; Zhang F; Xue A; Jiang L; Zhu Z; Kemper K; Yengo L; Zheng Z; Marioni RE; Montgomery GW; Deary IJ; Wray NR; Visscher PM; McRae AF; Yang J, 2018, Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood, http://dx.doi.org/10.1101/274472
    Preprints | 2018
    Xue A; Wu Y; Zhu Z; Zhang F; Kemper KE; Zheng Z; Yengo L; Lloyd-Jones LR; Sidorenko J; Wu Y; McRae AF; Visscher PM; Zeng J; Yang J, 2018, Novel susceptibility loci and genetic regulation mechanisms for type 2 diabetes, http://dx.doi.org/10.1101/284570
    Conference Papers | 2018
    Zeng J; de Vlaming R; Wu Y; Robinson MR; Lloyd-Jones LR; Yengo L; Yap CX; Xue A; Sidorenko J; Mcrae AF; Powell JE; Montgomery GW; Metspalu A; Esko T; Gibson G; Wray NR; Visscher PM; Yang J, 2018, 'Signatures of negative selection in the genetic architecture of human complex traits', in BEHAVIOR GENETICS, SPRINGER, MA, Boston, pp. 525 - 525, presented at 48th Annual Meeting of the Behavior-Genetics-Association (BGA), MA, Boston, 20 June 2018 - 23 June 2018, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000448359800199&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Preprints | 2017
    Zeng J; de Vlaming R; Wu Y; Robinson MR; Lloyd-Jones L; Yengo L; Yap C; Xue A; Sidorenko J; McRae AF; Powell JE; Montgomery GW; Metspalu A; Esko T; Gibson G; Wray NR; Visscher PM; Yang J, 2017, Widespread signatures of negative selection in the genetic architecture of human complex traits, http://dx.doi.org/10.1101/145755
    Theses / Dissertations |
    Xue A, Identification of genetic and modifiable risk factors for complex diseases, http://dx.doi.org/10.14264/8ec6fc5

2021 - DeLill Nasser Award for Professional Development in Genetics, Genetics Society of America

2020 - Chinese Scholarship Council Award for Outstanding Students Abroad

2020 - UQ IMB Writing-up Award

2019 - UQ IMB Travel Award for International Conference

2018 - UQ IMB Research Higher Degree Top-Up Scholarships

2018 - Outstanding Contribution in Reviewing Award, EBioMedicine Journal

2016 - University of Queensland International (UQI) Scholarship   

2015 - Outstanding Thesis Award for Bachelor Degree, Zhejiang University   

2015 - Summer Program Scholarship of the Council for Higher Education, the Government of Israel

2014 - Scholarship for Outstanding Performance in Research and Innovation, Zhejiang University

2013 - Gold Medal & Best Biobrick Measurement Approach, International Genetically Engineered Machine Competition, Asian region

Statistical genetics

Computational biology

Statistical modelling

Human complex traits

Single-cell genomics

eQTL mapping