Dr Ashwin Unnikrishnan

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I am a biomedical research scientist and Head of the Molecular Mechanisms in Leukaemia laboratory (https://www.unsw.edu.au/medicine-health/our-schools/clinical-medicine/research-impact/research-groups/cancer/molecular-mechanisms-leukaemia-lab) at the Lowy Cancer Research Centre, University of New South Wales.

My lab uses a combination of genomics, epigenomics, molecular biology and stem cell biology techniques to understand the mechanisms driving leukaemia, as well as those underpinning resistance to therapy. Our research interests are strongly geared towards translational medical outcomes.

We are always looking for talented, motivated scientists and students, so please get in touch (Twitter/LinkedIn/email) if you are interested in discussing opportunities in my lab.

Phone

+61 2 93858045

E-mail

ashwin.unnikrishnan@unsw.edu.au

Location

Adult Cancer Program, Level 2, Lowy Cancer Research Centre, University of New South Wales

Book Chapters | 2010

Tsukiyama T; Bogenschutz N; Kwong T; Rodriguez J; Unnikrishnan A; Yadon A, 2010, 'Chapter 283 ISWI Chromatin Remodeling Complexes', in Handbook of Cell Signaling, Elsevier, pp. 2357 - 2362, http://dx.doi.org/10.1016/b978-0-12-374145-5.00283-7

Book Chapters | 2009

Tsukiyama T; Bogenschutz N; Kwong T; Rodriguez J; Unnikrishnan A, 2009, 'ISWI Chromatin Remodeling Complexes', in Bradshaw RA; Dennis EA (ed.), Handbook of Cell Signaling (Second Edition), Academic Press, Oxford, pp. 2357 - 2362, http://dx.doi.org/10.1016/B978-0-12-374145-5.00283-7
Journal articles | 2023

Schnegg-Kaufmann AS; Thoms JAI; Bhuyan GS; Hampton HR; Vaughan L; Rutherford K; Kakadia PM; Lee HM; Johansson EMV; Failes TW; Arndt GM; Koval J; Lindeman R; Warburton P; Rodriguez-Meira A; Mead AJ; Unnikrishnan A; Davidson S; Polizzotto MN; Hertzberg M; Papaemmanuil E; Bohlander SK; Faridani OR; Jolly CJ; Zanini F; Pimanda JE, 2023, 'Contribution of mutant HSC clones to immature and mature cells in MDS and CMML, and variations with AZA therapy', Blood, 141, pp. 1316 - 1321, http://dx.doi.org/10.1182/blood.2022018602

Journal articles | 2022

Amaldoss MJN; Mehmood R; Yang JL; Koshy P; Kumar N; Unnikrishnan A; Sorrell CC, 2022, 'Anticancer therapeutic effect of cerium-based nanoparticles: known and unknown molecular mechanisms', Biomaterials Science, 10, pp. 3671 - 3694, http://dx.doi.org/10.1039/d2bm00334a

Journal articles | 2022

Amaldoss MJN; Pandzic E; Koshy P; Kumar N; Sorrell CC; Unnikrishnan A, 2022, 'Detection and quantification of nanoparticle-induced intracellular ROS in live cells by laser scanning confocal microscopy', Methods, 207, pp. 11 - 19, http://dx.doi.org/10.1016/j.ymeth.2022.08.005

Journal articles | 2022

Amaldoss MJN; Yang JL; Koshy P; Unnikrishnan A; Sorrell CC, 2022, 'Inorganic nanoparticle-based advanced cancer therapies: Promising combination strategies', Drug Discovery Today, 27, pp. 103386, http://dx.doi.org/10.1016/j.drudis.2022.103386

Journal articles | 2022

Chandrakanthan V; Rorimpandey P; Zanini F; Chacon D; Olivier J; Joshi S; Kang YC; Knezevic K; Huang Y; Qiao Q; Oliver RA; Unnikrishnan A; Carter DR; Lee B; Brownlee C; Power C; Brink R; Mendez-Ferrer S; Enikolopov G; Walsh W; Göttgens B; Taoudi S; Beck D; Pimanda JE, 2022, 'Mesoderm-derived PDGFRA⁺ cells regulate the emergence of hematopoietic stem cells in the dorsal aorta', Nature Cell Biology, 24, pp. 1211 - 1225, http://dx.doi.org/10.1038/s41556-022-00955-3

Journal articles | 2022

Liu L; Vujovic A; Deshpande NP; Sathe S; Anande G; Chen HTT; Xu J; Minden MD; Yeo GW; Unnikrishnan A; Hope KJ; Lu Y, 2022, 'The splicing factor RBM17 drives leukemic stem cell maintenance by evading nonsense-mediated decay of pro-leukemic factors', Nature Communications, 13, pp. 3833, http://dx.doi.org/10.1038/s41467-022-31155-0

Journal articles | 2022

Liu YC; Kwon J; Fabiani E; Xiao Z; Liu YV; Follo MY; Liu J; Huang H; Gao C; Liu J; Falconi G; Valentini L; Gurnari C; Finelli C; Cocco L; Liu JH; Jones AI; Yang J; Yang H; Thoms JAI; Unnikrishnan A; Pimanda JE; Pan R; Bassal MA; Voso MT; Tenen DG; Chai L, 2022, 'Demethylation and Up-Regulation of an Oncogene after Hypomethylating Therapy', New England Journal of Medicine, 386, pp. 1998 - 2010, http://dx.doi.org/10.1056/NEJMoa2119771

Journal articles | 2022

Pimanda JE; Thoms JA; Hampton HR; Davidson S; Joshi S; Sarowar CH; Lim XY; Nunez AC; Kakadia PM; Pickford R; Raftery M; Hough S; Buckland G; Bailey M; Ghodke Y; Absar N; Vaughan L; Pasalic L; Fong CY; Kenealy M; Hiwase D; Stoddart R; Mohammed S; Lee L; Passam FH; Spring K; Skarratt KK; Rebeiro P; Larsen SR; Presgrave P; Stevenson WS; Ling S; Tiley C; Fuller S; Roncolato F; Enjeti AK; Hoenemann D; Lemech C; Bohlander SK; Olivier J; Hertzberg M; Unnikrishnan A; Polizzotto MN, 2022, 'In Vivo Drug Incorporation and Intracellular Dynamics of Injectable Versus Oral Azacytidine: A Phase II Open Label Multicentre Trial', BLOOD, 140, pp. 6927 - 6929, http://dx.doi.org/10.1182/blood-2022-157634

Journal articles | 2022

Saini SK; Holmberg-Thydén S; Bjerregaard AM; Unnikrishnan A; Dorfmüller S; Platzbecker U; Tirado-Gonzalez I; Bönig H; El Fassi D; Grønbæk K; Pimanda J; Medyouf H; Hadrup SR, 2022, 'Neoantigen reactive T cells correlate with the low mutational burden in hematological malignancies', Leukemia, 36, pp. 2734 - 2738, http://dx.doi.org/10.1038/s41375-022-01705-y

Journal articles | 2022

Schnegg-Kaufmann A; Thoms J; Bhuyan GS; Henry H; Vaughan L; Rutherford K; Kakadia P; Johansson E; Failes T; Greg A; Koval J; Lindeman R; Warburton P; Rodriguez-Meira A; Mead A; Unnikrishnan A; Bohlander S; Pappaemmanuil E; Faridani O; Jolly C; Zanini F; Pimanda J, 2022, 'P748: SINGLE CELL GENOTYPING OF MATCHED BONE MARROW AND PERIPHERAL BLOOD CELLS IN TREATMENT NAIVE AND AZA-TREATED MDS AND CMML', HemaSphere, 6, pp. 643 - 644, http://dx.doi.org/10.1097/01.hs9.0000845876.01682.15

Journal articles | 2022

Thoms JA; Schnegg-Kaufmann A; Bhuyan GS; Hampton HR; Vaughan L; Rutherford K; Kakadia PM; Lee HM; Johansson E; Failes TW; Arndt GM; Koval J; Davidson S; Lindeman R; Warburton P; Rodriguez-Meira A; Mead AJ; Unnikrishnan A; Hertzberg M; Polizzotto MN; Papaemmanuil E; Bohlander SK; Faridani O; Jolly CJ; Zanini F; Pimanda JE, 2022, 'Clinical Response to Azacytidine (AZA) Is Associated with Increased Contribution from Mutated Blood Progenitors: Insights from Single Cell Genotyping of Matched Stem/Progenitor and Mature Blood Cells from MDS/CMML Patients Pre- and Post-AZA Treatment', BLOOD, 140, pp. 9751 - 9752, http://dx.doi.org/10.1182/blood-2022-163158

Journal articles | 2021

Chandrakanthan V; Rorimpandey P; Zanini F; Chacon D; Kang YC; Knezevic K; Huang Y; Qiao Q; Oliver R; Unnikrishnan A; Carter D; Lee B; Brownlee C; Power C; Mendez-Ferrer S; Enikolopov G; Walsh W; Göttgens B; Taoudi S; Beck D; Pimanda J, 2021, 'Mesoderm-Derived PDGFRA⁺Cells Regulate the Emergence of Hematopoietic Stem Cells in the Dorsal Aorta', , http://dx.doi.org/10.1101/2021.08.08.455592

Journal articles | 2021

Liu L; Vujovic A; Deshpande N; Sathe S; Anande G; Xu J; Minden M; Yeo G; Unnikrishnan A; Hope K; Lu Y, 2021, 'RBM17 Mediates Evasion of Pro-Leukemic Factors from Splicing-coupled NMD to Enforce Leukemic Stem Cell Maintenance', , http://dx.doi.org/10.21203/rs.3.rs-728533/v1

Journal articles | 2021

Lorenzi L; Chiu HS; Avila Cobos F; Gross S; Volders PJ; Cannoodt R; Nuytens J; Vanderheyden K; Anckaert J; Lefever S; Tay AP; de Bony EJ; Trypsteen W; Gysens F; Vromman M; Goovaerts T; Hansen TB; Kuersten S; Nijs N; Taghon T; Vermaelen K; Bracke KR; Saeys Y; De Meyer T; Deshpande NP; Anande G; Chen TW; Wilkins MR; Unnikrishnan A; De Preter K; Kjems J; Koster J; Schroth GP; Vandesompele J; Sumazin P; Mestdagh P, 2021, 'Publisher Correction: The RNA Atlas expands the catalog of human non-coding RNAs (Nature Biotechnology, (2021), 39, 11, (1453-1465), 10.1038/s41587-021-00936-1)', Nature Biotechnology, 39, pp. 1467, http://dx.doi.org/10.1038/s41587-021-00996-3

Journal articles | 2021

Lorenzi L; Chiu HS; Avila Cobos F; Gross S; Volders PJ; Cannoodt R; Nuytens J; Vanderheyden K; Anckaert J; Lefever S; Tay AP; de Bony EJ; Trypsteen W; Gysens F; Vromman M; Goovaerts T; Hansen TB; Kuersten S; Nijs N; Taghon T; Vermaelen K; Bracke KR; Saeys Y; De Meyer T; Deshpande NP; Anande G; Chen TW; Wilkins MR; Unnikrishnan A; De Preter K; Kjems J; Koster J; Schroth GP; Vandesompele J; Sumazin P; Mestdagh P, 2021, 'The RNA Atlas expands the catalog of human non-coding RNAs', Nature Biotechnology, 39, pp. 1453 - 1465, http://dx.doi.org/10.1038/s41587-021-00936-1

Journal articles | 2021

Yang J; Gao C; Liu M; Liu YC; Kwon J; Qi J; Tian X; Stein A; Liu YV; Kong NR; Wu Y; Yin S; Xi J; Chen Z; Kumari K; Wong H; Luo H; Silberstein LE; Thoms JAI; Unnikrishnan A; Pimanda JE; Tenen DG; Chai L, 2021, 'Targeting an Inducible SALL4-Mediated Cancer Vulnerability with Sequential Therapy', Cancer Research, 81, pp. 6018 - 6028, http://dx.doi.org/10.1158/0008-5472.CAN-21-0030

Journal articles | 2020

Anande G; Deshpande N; Mareschal S; Batcha A; Hampton H; Herold T; Lehmann S; Wilkins M; Wong JWH; Unnikrishnan A; Pimanda J, 2020, 'RNA splicing alterations induce a cellular stress response associated with poor prognosis in AML', , http://dx.doi.org/10.1101/2020.01.10.895714

Journal articles | 2020

Anande G; Deshpande NP; Mareschal S; Batcha AMN; Hampton HR; Herold T; Lehmann S; Wilkins MR; Wong JWH; Unnikrishnan A; Pimanda JE, 2020, 'RNA Splicing Alterations Induce a Cellular Stress Response Associated with Poor Prognosis in Acute Myeloid Leukemia', Clinical Cancer Research, 26, pp. 3597 - 3607, http://dx.doi.org/10.1158/1078-0432.CCR-20-0184

Journal articles | 2020

Khanna A; Thoms JAI; Stringer BW; Chung SA; Ensbey KS; Jue TR; Jahan Z; Subramanian S; Anande G; Shen H; Unnikrishnan A; McDonald KL; Day BW; Pimanda JE, 2020, 'Constitutive CHK1 Expression Drives a pSTAT3–CIP2A Circuit that Promotes Glioblastoma Cell Survival and Growth', Molecular Cancer Research, 18, pp. 709 - 722, http://dx.doi.org/10.1158/1541-7786.MCR-19-0934

Journal articles | 2020

Saini SK; Ørskov A; Bjerregaard A-M; Unnikrishnan A; Holmberg-Thydén S; Borch A; Anande G; Bentzen A; Marquard A; Tamhane T; Gang A; Defva I; Szallasi Z; Eklund A; Pimanda J; Grønbæk K; Hadrup S, 2020, 'Human endogenous retroviruses form a reservoir of T cell targets in hematological cancers with low mutational burden', The Journal of Immunology, 204, pp. 242.14 - 242.14, http://dx.doi.org/10.4049/jimmunol.204.supp.242.14

Journal articles | 2020

Saini SK; Ørskov AD; Bjerregaard AM; Unnikrishnan A; Holmberg-Thydén S; Borch A; Jensen KV; Anande G; Bentzen AK; Marquard AM; Tamhane T; Treppendahl MB; Gang AO; Dufva IH; Szallasi Z; Ternette N; Pedersen AG; Eklund AC; Pimanda J; Grønbæk K; Hadrup SR, 2020, 'Human endogenous retroviruses form a reservoir of T cell targets in hematological cancers', Nature Communications, 11, http://dx.doi.org/10.1038/s41467-020-19464-8

Journal articles | 2019

Kumar P; Beck D; Galeev R; Thoms JAI; Talkhoncheh MS; de Jong I; Unnikrishnan A; Baudet A; Subramaniam A; Pimanda JE; Larsson J, 2019, 'HMGA2 promotes long-term engraftment and myeloerythroid differentiation of human hematopoietic stem and progenitor cells', Blood Advances, 3, pp. 681 - 691, http://dx.doi.org/10.1182/bloodadvances.2018023986

Journal articles | 2018

Ali A; Penneroux J; Dal Bello R; Massé A; Quentin S; Unnikrishnan A; Hernandez L; Raffoux E; Ben Abdelali R; Renneville A; Preudhomme C; Pimanda J; Dombret H; Soulier J; Fenaux P; Clappier E; Adès L; Puissant A; Itzykson R, 2018, 'Granulomonocytic progenitors are key target cells of azacytidine in higher risk myelodysplastic syndromes and acute myeloid leukemia', Leukemia, 32, pp. 1856 - 1860, http://dx.doi.org/10.1038/s41375-018-0076-2

Journal articles | 2018

Smeets MF; Tan SY; Xu JJ; Anande G; Unnikrishnan A; Chalk AM; Taylor SR; Pimanda JE; Wall M; Purton LE; Walkley CR, 2018, 'Srsf2^P95H initiates myeloid bias and myelodysplastic/ myeloproliferative syndrome from hemopoietic stem cells', Blood, 132, pp. 608 - 621, http://dx.doi.org/10.1182/blood-2018-04-845602

Journal articles | 2018

Unnikrishnan A; Vo ANQ; Pickford R; Raftery MJ; Nunez AC; Verma A; Hesson LB; Pimanda JE, 2018, 'AZA-MS: A novel multiparameter mass spectrometry method to determine the intracellular dynamics of azacitidine therapy in vivo', Leukemia, 32, pp. 900 - 910, http://dx.doi.org/10.1038/leu.2017.340

Journal articles | 2017

Unnikrishnan A; Papaemmanuil E; Beck D; Deshpande NP; Verma A; Kumari A; Woll PS; Richards LA; Knezevic K; Chandrakanthan V; Thoms JAI; Tursky ML; Huang Y; Ali Z; Olivier J; Galbraith S; Kulasekararaj AG; Tobiasson M; Karimi M; Pellagatti A; Wilson SR; Lindeman R; Young B; Ramakrishna R; Arthur C; Stark R; Crispin P; Curnow J; Warburton P; Roncolato F; Boultwood J; Lynch K; Jacobsen SEW; Mufti GJ; Hellstrom-Lindberg E; Wilkins MR; MacKenzie KL; Wong JWH; Campbell PJ; Pimanda JE, 2017, 'Integrative Genomics Identifies the Molecular Basis of Resistance to Azacitidine Therapy in Myelodysplastic Syndromes', Cell Reports, 20, pp. 572 - 585, http://dx.doi.org/10.1016/j.celrep.2017.06.067

Journal articles | 2016

Botezatu L; Michel LC; Makishima H; Schroeder T; Germing U; Haas R; Van der Reijden B; Marneth AE; Bergevoet SM; Jansen JH; Przychodzen B; Wlodarski M; Niemeyer C; Platzbecker U; Ehninger G; Unnikrishnan A; Beck D; Pimanda J; Hellström-Lindberg E; Malcovati L; Boultwood J; Pellagatti A; Papaemmanuil E; Le Coutre P; Kaeda J; Opalka B; Möröy T; Dührsen U; Maciejewski J; Khandanpour C, 2016, 'GFI1^36N as a therapeutic and prognostic marker for myelodysplastic syndrome', Experimental Hematology, 44, pp. 590 - 595.e1, http://dx.doi.org/10.1016/j.exphem.2016.04.001

Journal articles | 2016

Chandrakanthan V; Yeola A; Kwan JC; Oliver RA; Qiao Q; Kang YC; Zarzour P; Beck D; Boelen L; Unnikrishnan A; Villanueva JE; Nunez AC; Knezevic K; Palu C; Nasrallah R; Carnell M; Macmillan A; Whan R; Yu Y; Hardy P; Grey ST; Gladbach A; Delerue F; Ittner L; Mobbs R; Walkley CR; Purton LE; Ward RL; Wong JWH; Hesson LB; Walsh W; Pimanda JE, 2016, 'Pdgf-ab and 5-Azacytidine induce conversion of somatic cells into tissue-regenerative multipotent stem cells', Proceedings of the National Academy of Sciences of the United States of America, 113, pp. E2306 - E2315, http://dx.doi.org/10.1073/pnas.1518244113

Journal articles | 2016

Nasrallah R; Fast EM; Solaimani P; Knezevic K; Eliades A; Patel R; Thambyrajah R; Unnikrishnan A; Thoms J; Beck D; Vink CS; Smith A; Wong J; Shepherd M; Kent D; Roychoudhuri R; Paul F; Klippert J; Hammes A; Willnow T; Göttgens B; Dzierzak E; Zon LI; Lacaud G; Kouskoff V; Pimanda JE, 2016, 'Identification of novel regulators of developmental hematopoiesis using Endoglin regulatory elements as molecular probes', Blood, 128, pp. 1928 - 1939, http://dx.doi.org/10.1182/blood-2016-02-697870

Journal articles | 2016

Poulos RC; Thoms JAI; Guan YF; Unnikrishnan A; Pimanda JE; Wong JWH, 2016, 'Functional Mutations Form at CTCF-Cohesin Binding Sites in Melanoma Due to Uneven Nucleotide Excision Repair across the Motif', Cell Reports, 17, pp. 2865 - 2872, http://dx.doi.org/10.1016/j.celrep.2016.11.055

Journal articles | 2016

Unnikrishnan A; Guan YF; Huang Y; Beck D; Thoms JAI; Peirs S; Knezevic K; Ma S; De Walle IV; De Jong IDE; Ali Z; Zhong L; Raftery MJ; Taghon T; Larsson J; MacKenzie KL; Van Vlierberghe P; Wong JWH; Pimanda JE, 2016, 'A quantitative proteomics approach identifies ETV6 and IKZF1 as new regulators of an ERG-driven transcriptional network', Nucleic Acids Research, 44, pp. 10644 - 10661, http://dx.doi.org/10.1093/nar/gkw804

Journal articles | 2015

Lacramioara B; Makishima H; Michel L; Hoenes J; Marneth A; van der Reijden B; Radiovoyevich T; Germing U; Haas R; Schroeder T; Vadnais C; Helness A; Pimanda J; Jansen J; Unnikrishnan A; Platzbecker U; Papaemmanuil E; Ehninger G; Moroy T; Duhrsen U; Maciejewski J; Khandanpour C, 2015, '72 PERSONALIZED TREATMENT APPROACH FOR GFI136N HETEROZYGOUS OR HOMOZYGOUS MDS PATIENTS', Leukemia Research, 39, pp. S35 - S35, http://dx.doi.org/10.1016/s0145-2126(15)30073-4

Journal articles | 2015

Tursky ML; Beck D; Thoms JAI; Huang Y; Kumari A; Unnikrishnan A; Knezevic K; Evans K; Richards LA; Lee E; Morris J; Goldberg L; Izraeli S; Wong JWH; Olivier J; Lock RB; MacKenzie KL; Pimanda JE, 2015, 'Overexpression of ERG in cord blood progenitors promotes expansion and recapitulates molecular signatures of high ERG leukemias', Leukemia, 29, pp. 819 - 827, http://dx.doi.org/10.1038/leu.2014.299

Journal articles | 2015

Woll PS; Kjaellquist U; Chowdhury O; Doolittle H; Wedge DC; Thongjuea S; Erlandsson R; Ngara M; Anderson K; Deng Q; Mead AJ; Stenson L; Giustacchini A; Duarte S; Giannoulatou E; Taylor S; Karimi M; Scharenberg C; Mortera-Blanco T; Macaulay IC; Clark S-A; Dybedal I; Josefsen D; Fenaux P; Hokland P; Holm MS; Cazzola M; Malcovati L; Tauro S; Bowen D; Boultwood J; Pellagatti A; Pimanda JE; Unnikrishnan A; Vyas P; Goehring G; Schlegelberger B; Tobiasson M; Kvalheim G; Constantinescu SN; Nerlov C; Nilsson L; Campbell PJ; Sandberg R; Papaemmanuil E; Hellstroem-Lindberg E; Linnarsson S; Jacobsen SEW, 2015, 'Myelodysplastic Syndromes Are Propagated by Rare and Distinct Human Cancer Stem Cells In Vivo (vol 25, pg 794, 2014)', CANCER CELL, 27, pp. 603 - 605, http://dx.doi.org/10.1016/j.ccell.2015.03.003

Journal articles | 2015

Woll PS; Kjällquist U; Chowdhury O; Doolittle H; Wedge DC; Thongjuea S; Erlandsson R; Ngara M; Anderson K; Deng Q; Mead AJ; Stenson L; Giustacchini A; Duarte S; Giannoulatou E; Taylor S; Karimi M; Scharenberg C; Mortera-Blanco T; Macaulay IC; Clark SA; Dybedal I; Josefsen D; Fenaux P; Hokland P; Holm MS; Cazzola M; Malcovati L; Tauro S; Bowen D; Boultwood J; Pellagatti A; Pimanda JE; Unnikrishnan A; Vyas P; Göhring G; Schlegelberger B; Tobiasson M; Kvalheim G; Constantinescu SN; Nerlov C; Nilsson L; Campbell PJ; Sandberg R; Papaemmanuil E; Hellström-Lindberg E; Linnarsson S; Jacobsen SEW, 2015, 'Erratum to Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo, [Cancer Cell, 25, 2014, 794-808]', Cancer Cell, 27, pp. 603 - 605, http://dx.doi.org/10.1016/j.ccell.2015.03.003

Journal articles | 2014

Ju YSE; Alexandrov LB; Gerstung M; Martincorena I; Nik-Zainal S; Ramakrishna M; Davies HR; Papaemmanuil E; Gundem G; Shlien A; Bolli N; Behjati S; Tarpey PS; Nangalia J; Massie CE; Butler AP; Teague JW; Vassiliou GS; Green AR; Du MQ; Unnikrishnan A; Pimanda JE; Teh BTE; Munshi N; Greaves M; Vyas P; El-Naggar AK; Santarius T; Collins VP; Grundy R; Taylor JA; Hayes DN; Malkin D; Foster CS; Warren AY; Whitaker HC; Brewer D; Eeles R; Cooper C; Neal D; Visakorpi T; Isaacs WB; Bova GS; Flanagan AM; Futreal PA; Lynch AG; Chinnery PF; McDermott U; Stratton MR; Campbell PJ, 2014, 'Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer', eLife, 3, http://dx.doi.org/10.7554/eLife.02935

Journal articles | 2014

Tobiasson M; Karimi M; Dimitriou M; Qu Y; Lennartsson A; Ali HA; Unnikrishnan A; Jadersten M; Jansson M; Ben Azenkoud A; Pimanda JE; Ekwall K; Ungerstedt J; Lehmann S; Hellstrom-Lindberg E, 2014, 'Mutations in Histone Modulators and HOXA5 Methylation Levels Affects Survival in Azacitidine Treated MDS Patients', BLOOD, 124, http://www.bloodjournal.org/content/124/21/4613

Journal articles | 2014

Woll PS; Kjaellquist U; Chowdhury O; Doolittle H; Wedge DC; Thongjuea S; Erlandsson R; Ngara M; Anderson K; Deng Q; Mead AJ; Stenson L; Giustacchini A; Duarte S; Giannoulatou E; Taylor S; Karimi M; Scharenberg C; Mortera-Blanco T; Macaulay IC; Clark S-A; Dybedal I; Josefsen D; Fenaux P; Hokland P; Holm MS; Cazzola M; Malcovati L; Tauro S; Bowen D; Boultwood J; Pellagatti A; Pimanda JE; Unnikrishnan A; Vyas P; Goehring G; Schlegelberger B; Tobiasson M; Kvalheim G; Constantinescu SN; Nerlov C; Nilsson L; Campbell PJ; Sandberg R; Papaemmanuil E; Hellstroem-Lindberg E; Linnarsson S; Jacobsen SEW, 2014, 'Myelodysplastic Syndromes Are Propagated by Rare and Distinct Human Cancer Stem Cells In Vivo (vol 25, pg 794, 2014)', CANCER CELL, 25, pp. 861 - 861, http://dx.doi.org/10.1016/j.ccr.2014.05.027

Journal articles | 2013

Beck D; Thoms JAI; Perera D; Schütte J; Unnikrishnan A; Knezevic K; Kinston SJ; Wilson NK; O'Brien TA; Göttgens B; Wong JWH; Pimanda JE, 2013, 'Genome-wide analysis of transcriptional regulators in human HSPCs reveals a densely interconnected network of coding and noncoding genes', Blood, 122, pp. e12 - e22, http://dx.doi.org/10.1182/blood-2013-03-490425

Journal articles | 2012

Beck D; Brandl MB; boelen L; Unnikrishnan A; Pimanda JE; Wong JWH, 2012, 'Signal analysis for genome-wide maps of histone modifications measured by ChIP-seq', Bioinformatics, 28, pp. 1062 - 1069, http://dx.doi.org/10.1093/bioinformatics/bts085

Journal articles | 2012

Unnikrishnan A; Akiyoshi B; Biggins S; Tsukiyama T, 2012, 'An efficient purification system for native minichromosome from Saccharomyces cerevisiae', Methods in Molecular Biology, 833, pp. 115 - 123, http://dx.doi.org/10.1007/978-1-61779-477-3_8

Journal articles | 2010

Unnikrishnan A; Gafken PR; Tsukiyama T, 2010, 'Dynamic changes in histone acetylation regulate origins of DNA replication', Nature Structural & Molecular Biology, 17, pp. 430 - 437, http://dx.doi.org/10.1038/nsmb.1780
Other | 2023

Khanna A; Thoms JAI; Stringer BW; Chung SA; Ensbey KS; Jue TR; Jahan Z; Subramanian S; Anande G; Shen H; Unnikrishnan A; McDonald KL; Day BW; Pimanda JE, 2023, Supplementary methods and figures from Constitutive CHK1 Expression Drives a pSTAT3–CIP2A Circuit that Promotes Glioblastoma Cell Survival and Growth, , http://dx.doi.org/10.1158/1541-7786.22515163

Other | 2023

Khanna A; Thoms JAI; Stringer BW; Chung SA; Ensbey KS; Jue TR; Jahan Z; Subramanian S; Anande G; Shen H; Unnikrishnan A; McDonald KL; Day BW; Pimanda JE, 2023, Supplementary methods and figures from Constitutive CHK1 Expression Drives a pSTAT3–CIP2A Circuit that Promotes Glioblastoma Cell Survival and Growth, , http://dx.doi.org/10.1158/1541-7786.22515163.v1

Preprints | 2023

Tan S; Joseph C; Chalk AM; Hendy J; Fabb S; Schleibs K; Lee SC; Tjin G; Grace CS; Madugalle V; Smeets MF; Maluenda AC; Rice KL; Baker EK; Nandurkar H; Slape CI; Parker MW; Unnikrishnan A; Mufti GJ; Tobiasson M; Hellstrom-Lindberg E; Pimanda JE; Gudas LJ; Holien JK; Walkley CR; Wall M; Purton LE, 2023, Dysregulated expression ofHoxa1isoforms in hematopoietic stem and progenitor cells causes myelodysplastic syndromes, , http://dx.doi.org/10.1101/2023.04.24.538176

Preprints | 2022

Schnegg-Kaufmann A; Thoms J; Bhuyan GS; Hampton H; Vaughan L; Rutherford K; Kakadia P; Johansson E; Failes T; Arndt G; Koval J; Lindeman R; Warburton P; Rodriguez-Meira A; Mead A; Unnikrishnan A; Bohlander S; Papaemmanuil E; Faridani O; Jolly C; Zanini F; Pimanda J, 2022, Single cell genotyping of matched bone marrow and peripheral blood cells in treatment naive and AZA-treated MDS and CMML, , http://dx.doi.org/10.1101/2022.01.20.476890

Preprints | 2020

Liu Y-C; Fabiani E; Kwon J; Gao C; Falconi G; Valentini L; Gurnari C; Liu YV; Jones AI; Yang J; Yang H; Thoms JAI; Unnikrishnan A; Pimanda JE; Pan R; Voso MT; Tenen DG; Chai L, 2020, Demethylation and upregulation of an oncogene post hypomethylating treatment, , http://dx.doi.org/10.1101/2020.07.21.20157776

Preprints | 2020

Yang J; Gao C; Liu M; Chen Z; Liu Y-C; Kwon J; Qi J; Tian X; Stein A; Liu Y; Kong NR; Wu Y; Yin S; Xi JJ; Luo H; Silberstein LE; Thoms JAI; Unnikrishnan A; Pimanda JE; Tenen DG; Chai L, 2020, Induction of a SALL4-dependency for targeted cancer therapy, , http://dx.doi.org/10.1101/2020.07.10.197434

Conference Papers | 2019

Anande G; Unnikrishnan A; Deshpande N; Mareschal S; Batcha AMN; Herold T; Lehmann S; Wilkins M; Wong J; Pimanda J, 2019, 'Identification of Recurrent Alternative RNA Splicing in Adverse-Risk Acute Myeloid Leukemia', in BLOOD, AMER SOC HEMATOLOGY, FL, Orlando, presented at 61st Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), FL, Orlando, 07 December 2019 - 10 December 2019, http://dx.doi.org/10.1182/blood-2019-129537

Preprints | 2019

Lorenzi L; Chiu H-S; Cobos FA; Gross S; Volders P-J; Cannoodt R; Nuytens J; Vanderheyden K; Anckaert J; Lefever S; Goovaerts T; Hansen TB; Kuersten S; Nijs N; Taghon T; Vermaelen K; Bracke KR; Saeys Y; De Meyer T; Deshpande N; Anande G; Chen T-W; Wilkins MR; Unnikrishnan A; De Preter K; Kjems J; Koster J; Schroth GP; Vandesompele J; Sumazin P; Mestdagh P, 2019, The RNA Atlas, a single nucleotide resolution map of the human transcriptome, , http://dx.doi.org/10.1101/807529

Conference Papers | 2019

Saini SK; Bjerregaard A-M; Orskov AD; Unnikrishnan A; Holmberg S; Anande G; Bentzen AK; Szallasi Z; Eklund AC; Gronbaek K; Hadrup SR, 2019, 'Human endogenous retroviruses as a potential reservoir for T-cell mediated cancer immunotherapy', in CANCER IMMUNOLOGY RESEARCH, AMER ASSOC CANCER RESEARCH, http://dx.doi.org/10.1158/2326-6074.CRICIMTEATIAACR18-B129

Conference Papers | 2019

Unnikrishnan A; Lim XY; Joshi S; Nunez AC; Vaughan L; Pickford R; Hough S; Davidson S; Fong C; Kenealy M; Hiwase DK; Pasalic L; Mohammed S; Lee L; Passam FH; Spring K; Rebeiro P; Ling S; Fuller S; Presgrave P; Roncolato F; Larsen S; Enjeti AK; Stevenson WS; Tiley C; Campbell PJ; Lemech C; Olivier J; Hertzberg M; Polizzotto MN; Pimanda J, 2019, 'In Vivo Assessment of Intracellular Dynamics Comparing Injection Versus Oral Azacitidine in a Phase IIb Investigator Initiated Clinical Trial', in BLOOD, AMER SOC HEMATOLOGY, FL, Orlando, presented at 61st Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), FL, Orlando, 07 December 2019 - 10 December 2019, http://dx.doi.org/10.1182/blood-2019-123921

Conference Abstracts | 2018

Sonderegger S; Cerruti L; Tremblay C; Toulmin E; Saw J; Nebl T; Hannan KM; Lane SW; Falk H; Unnikrishnan A; Stupple P; Street I; Jane S; Altura R; Nicholson B; Curtis DJ, 2018, 'Small-Molecule Inhibition of PRMT5 Induces Translational Stress and p53 in JAK2V617F Mutant Myeloproliferative Neoplasms', in BLOOD, AMER SOC HEMATOLOGY, CA, San Diego, Vol. 132, presented at 60th Annual Meeting of the American-Society-of-Hematology (ASH), CA, San Diego, 01 December 2018 - 04 December 2018, http://dx.doi.org/10.1182/blood-2018-99-118406

Conference Papers | 2017

Ali A; Penneroux J; Dal Bello R; Masse A; Quentin S; Unnikrishnan A; Hernandez L; Raffoux E; Benabelali R; Renneville A; Preudhomme C; Pimanda J; Dombret H; Soulier J; Fenaux P; Clappier E; Ades L; Itzykson R, 2017, 'Granulomonocytic Progenitors (GMPs) Are Key Target Cells of Azacitidine in MDS and AML', in BLOOD, AMER SOC HEMATOLOGY, GA, Atlanta, presented at 59th Annual Meeting of the American-Society-of-Hematology (ASH), GA, Atlanta, 09 December 2017 - 12 December 2017, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000432419401234&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Presentations | 2017

Chandrakanthan V; Kang YC; Knezevic K; Qiao Q; Oliver R; Unnikrishnan A; Huang Y; Walsh W; Lee B; Lee CB; Power C; Beck D; Taoudi S; Pimanda J, 2017, 'DECLINED PRESENTATION MESENCHYMAL STEM CELL-LIKE CELL MEDIATED HEMATOPOIETIC STEM CELL GENERATION FROM NON-HEMOGENIC ENDOTHELIAL CELLS', Vol. 53, pp. S118 - S119, http://dx.doi.org/10.1016/j.exphem.2017.06.296

Conference Abstracts | 2017

Unnikrishnan A; Quynh AVN; Pickford R; Nunez A; Hesson L; Pimanda J, 2017, 'A NOVEL MASS SPECTROMETRY METHOD REVEALS THE INTRACELLULAR PHARMACOKINETICS OF AZACYTIDINE THERAPY IN VIVO', in HAEMATOLOGICA, FERRATA STORTI FOUNDATION, SPAIN, Madrid, Vol. 102, pp. 258 - 259, presented at 22nd Congress of the European-Hematology-Association, SPAIN, Madrid, 22 June 2017 - 25 June 2017, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000404127002145&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Proceedings (Editor of) | 2017

2017, 'Genetic Fate Mapping of Mesenchymal Stem-Like Cells in the Aorta-Gonad Mesonephros (AGM) and Their Contribution to Definitive Hematopoiesis', ELSEVIER SCIENCE BV, SINGAPORE, Natil Univ Singapore, Singapore, Vol. 145, pp. S55 - S56, presented at 18th International Congress of Developmental Biology, SINGAPORE, Natil Univ Singapore, Singapore, 18 June 2017 - 22 June 2017, http://dx.doi.org/10.1016/j.mod.2017.04.109

Conference Abstracts | 2016

Chandrakanthan V; Yeola A; Kwan JC; Oliver RA; Qiao Q; Kang YC; Zarzour P; Beck D; Boelen L; Unnikrishnan A; Villanueva JE; Nunez AC; Knezevic K; Palu C; Nasrallah R; Carnell M; Macmillan A; Whan R; Yu Y; Hardy P; Grey ST; Gladbach A; Delerue F; Ittner L; Mobbs R; Walkley CR; Purton LE; Ward RL; Wong JWH; Hesson LB; Walsh W; Pimanda JE, 2016, 'PDGF-AB and 5-Azacytidine induce conversion of somatic cells into tissue-regenerative multipotent stem cells', in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, NATL ACAD SCIENCES, Vol. 113, pp. E2306 - E2315, http://dx.doi.org/10.1073/pnas.1518244113

Conference Abstracts | 2016

Unnikrishnan A; Papaemmanuil E; Beck D; Verma A; Kumari A; Woll P; Richards L; Knezevic K; Chandrakanthan V; Thoms J; Tursky M; Huang Y; Ali Z; Olivier J; Galbraith S; Kulasekararaj A; Tobiasson M; Karimi M; Pellagatti A; Wilson S; Lindeman R; Young B; Ramakrishna R; Arthur C; Stark R; Crispin P; Curnow J; Warburton P; Roncolato F; Boultwood J; Lynch K; Jacobsen S; Mufti G; Hellstrom-Lindberg E; MacKenzie K; Wong J; Campbell P; Pimanda J, 2016, 'INTEGRATIVE GENOMICS IDENTIFIES THE MOLECULAR BASIS OF RESISTANCE TO AZACITIDINE THERAPY IN MYELODYSPLASTIC SYNDROMES', in HAEMATOLOGICA, FERRATA STORTI FOUNDATION, DENMARK, Copenhagen, Vol. 101, pp. 157 - 158, presented at 21st Congress of the European-Hematology-Association, DENMARK, Copenhagen, 09 June 2016 - 12 June 2016, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000379484600349&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Papers | 2016

Unnikrishnan A; Papaemmanuil E; Beck D; Verma A; Kumari A; Woll P; Richards L; Knezevic K; Chandrakanthan V; Thoms J; Tursky ML; Huang Y; Ali Z; Olivier S; Galbraith S; Kulasekararaj A; Tobiasson M; Karimi M; Pellagatti A; Wilson S; Lindeman R; Young B; Ramakrishna R; Arthur C; Stark R; Crispin P; Curnow J; Warburton P; Roncolato F; Boultwood J; Lynch K; Jacobsen S; Mufti G; Hellstrom-Lindberg E; MacKenzie K; Wong J; Campbell P; Pimanda J, 2016, 'Integrative genomics identifies the molecular basis of resistance to Azacitidine therapy in Myelodysplastic Syndromes', in Integrative genomics identifies the molecular basis of resistance to Azacitidine therapy in Myelodysplastic Syndromes, Ferrata Storti Foundation, Copenhagen, Denmark, pp. 157 - 158, presented at 21st Congress Of The European Hematology Association (EHA), Copenhagen, Denmark, 09 June 2016 - 12 June 2016, https://synapse.mskcc.org/synapse/works/97032

Conference Papers | 2015

Lacramioara B; Makishima H; Michel L; Hoenes J; Marneth A; van der Reijden B; Radiovoyevich T; Germing U; Haas R; Schroeder T; Vadnais C; Helness A; Pimanda J; Jansen J; Unnikrishnan A; Platzbecker U; Papaemmanuil E; Ehninger G; Moroy T; Duhrsen U; Maciejewski J; Khandanpour C, 2015, 'PERSONALIZED TREATMENT APPROACH FOR GFI136N HETEROZYGOUS OR HOMOZYGOUS MDS PATIENTS', in LEUKEMIA RESEARCH, PERGAMON-ELSEVIER SCIENCE LTD, DC, Washington, pp. S35 - S35, presented at 13th International Symposium on Myelodysplastic Syndromes (MDS), DC, Washington, 29 April 2015 - 02 May 2015, http://dx.doi.org/10.1016/S0145-2126(15)30073-4

Conference Papers | 2015

Unnikrishnan A; Papaemmanuil E; Beck D; Kumari A, 2015, 'An Integrative Genomics Approach Uncovers the Basis of Resistance to AZA Therapy in MDS and CMML', in An Integrative Genomics Approach Uncovers the Basis of Resistance to, AMER SOC HEMATOLOGY, USA, presented at ASH Annual Meeting, USA, 05 December 2015 - 08 December 2015, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000368019002147&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Conference Papers | 2014

Unnikrishnan A; Beck D; Verma A; Richards LA; Thoms JAI; Kumari A; Galbraith S; Kulasekararaj A; Tobiasson M; Woll PS; Pellagatti A; Papaemmanuil E; Wilson SR; Lindeman R; Campbell PJ; Boultwood J; Lynch K; Jacobsen SEW; Mufti GJ; Hellstrom-Lindberg E; MacKenzie KL; Wong JWH; Pimanda JE, 2014, 'Identification of a Prognostic Gene Expression Signature for AZA Response in MDS and CMML Patients', in BLOOD, AMER SOC HEMATOLOGY, CA, San Francisco, presented at 56th Annual Meeting of the American-Society-of-Hematology, CA, San Francisco, 06 December 2014 - 09 December 2014, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000349243501166&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Papers | 2013

Beck D; Thoms J; Perera D; Unnikrishnan A; Knezevic K; O'Brien T; Gottgens B; Wong J; Pimanda J, 2013, 'GENOME-WIDE ANALYSIS OF TRANSCRIPTIONAL REGULATORS IN HUMAN HSCS REVEALS A DENSELY INTERCONNECTED NETWORK OF CODING AND NON-CODING GENES', in EXPERIMENTAL HEMATOLOGY, ELSEVIER SCIENCE INC, AUSTRIA, Vienna, pp. S17 - S17, presented at 42nd Annual Scientific Meeting of the International-Society-for-Experimental-Hematology-and-Stem-Cells (ISEH), AUSTRIA, Vienna, 22 August 2013 - 25 August 2013, http://dx.doi.org/10.1016/j.exphem.2013.05.063

Conference Papers | 2013

Donald MR; Unnikrishnan A; Pimanda JE; Wilson S, 2013, 'Model Comparisons for RNA-Seq Data', in Proceedings of the 28th International Workshop on Statistical Modelling, 28th International Workshop on Statistical Modelling, Palermo, Italy, pp. 563 - 566, presented at 28th International Workshop on Statistical Modelling, Palermo, Italy, 08 July 2013 - 12 July 2014

My Research Supervision

Postdoctoral researchers:

Dr. Govardhan Anande

Higher Degree Students:

Dr. Lachlin Vaughan (Haematologist, PhD Student)

Newton Amaldoss (UNSW Scientia PhD Student)

Onkar Mulay (Masters Student)

Undergraduate Students:

Rohan Barar (Undergraduate Medical Student, Honours)

Beau Jesser (School of Medical Sciences, Honours)

Jungmin Ryu (School of Medical Sciences, Honours)

Research Staff:

Mangalangi Udayakumar

Lizzie Richardson

Dr Ashwin Unnikrishnan

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