Dr Ashwin Unnikrishnan
Senior Lecturer

Dr Ashwin Unnikrishnan

Medicine & Health
School of Clinical Medicine

I am a biomedical research scientist and Head of the Molecular Mechanisms in Leukaemia laboratory (https://www.unsw.edu.au/medicine-health/our-schools/clinical-medicine/research-impact/research-groups/cancer/molecular-mechanisms-leukaemia-lab) at the Lowy Cancer Research Centre, University of New South Wales.


My lab uses a combination of genomics, epigenomics, molecular biology and stem cell biology techniques to understand the mechanisms driving leukaemia, as well as those underpinning resistance to therapy. Our research interests are strongly geared towards translational medical outcomes.


We are always looking for talented, motivated scientists and students, so please get in touch (Twitter/LinkedIn/email) if you are interested in discussing opportunities in my lab.

Phone
+61 2 93858045
Location
Adult Cancer Program, Level 2, Lowy Cancer Research Centre, University of New South Wales
  • Journal articles | 2022
    Amaldoss MJN; Yang JL; Koshy P; Unnikrishnan A; Sorrell CC, 2022, 'Inorganic nanoparticle-based advanced cancer therapies: Promising combination strategies', Drug Discovery Today, vol. 27, pp. 103386, http://dx.doi.org/10.1016/j.drudis.2022.103386
    Journal articles | 2022
    Chandrakanthan V; Rorimpandey P; Zanini F; Chacon D; Olivier J; Joshi S; Kang YC; Knezevic K; Huang Y; Qiao Q; Oliver RA; Unnikrishnan A; Carter DR; Lee B; Brownlee C; Power C; Brink R; Mendez-Ferrer S; Enikolopov G; Walsh W; Göttgens B; Taoudi S; Beck D; Pimanda JE, 2022, 'Mesoderm-derived PDGFRA+ cells regulate the emergence of hematopoietic stem cells in the dorsal aorta', Nature Cell Biology, vol. 24, pp. 1211 - 1225, http://dx.doi.org/10.1038/s41556-022-00955-3
    Journal articles | 2022
    Liu YC; Kwon J; Fabiani E; Xiao Z; Liu YV; Follo MY; Liu J; Huang H; Gao C; Liu J; Falconi G; Valentini L; Gurnari C; Finelli C; Cocco L; Liu JH; Jones AI; Yang J; Yang H; Thoms JAI; Unnikrishnan A; Pimanda JE; Pan R; Bassal MA; Voso MT; Tenen DG; Chai L, 2022, 'Demethylation and Up-Regulation of an Oncogene after Hypomethylating Therapy', New England Journal of Medicine, vol. 386, pp. 1998 - 2010, http://dx.doi.org/10.1056/NEJMoa2119771
    Journal articles | 2021
    Chandrakanthan V; Rorimpandey P; Zanini F; Chacon D; Kang YC; Knezevic K; Huang Y; Qiao Q; Oliver R; Unnikrishnan A; Carter D; Lee B; Brownlee C; Power C; Mendez-Ferrer S; Enikolopov G; Walsh W; Göttgens B; Taoudi S; Beck D; Pimanda J, 2021, 'Mesoderm-Derived PDGFRA+ Cells Regulate the Emergence of Hematopoietic Stem Cells in the Dorsal Aorta', , http://dx.doi.org/10.1101/2021.08.08.455592
    Journal articles | 2016
    Botezatu L; Michel LC; Makishima H; Schroeder T; Germing U; Haas R; Van der Reijden B; Marneth AE; Bergevoet SM; Jansen JH; Przychodzen B; Wlodarski M; Niemeyer C; Platzbecker U; Ehninger G; Unnikrishnan A; Beck D; Pimanda J; Hellström-Lindberg E; Malcovati L; Boultwood J; Pellagatti A; Papaemmanuil E; Le Coutre P; Kaeda J; Opalka B; Möröy T; Dührsen U; Maciejewski J; Khandanpour C, 2016, 'GFI136N as a therapeutic and prognostic marker for myelodysplastic syndrome', Experimental Hematology, vol. 44, pp. 590 - 595.e1, http://dx.doi.org/10.1016/j.exphem.2016.04.001
    Journal articles | 2016
    Chandrakanthan V; Yeola A; Kwan JC; Oliver RA; Qiao Q; Kang YC; Zarzour P; Beck D; Boelen L; Unnikrishnan A; Villanueva JE; Nunez AC; Knezevic K; Palu C; Nasrallah R; Carnell M; Macmillan A; Whan R; Yu Y; Hardy P; Grey ST; Gladbach A; Delerue F; Ittner L; Mobbs R; Walkley CR; Purton LE; Ward RL; Wong JWH; Hesson LB; Walsh W; Pimanda JE, 2016, 'Pdgf-ab and 5-Azacytidine induce conversion of somatic cells into tissue-regenerative multipotent stem cells', Proceedings of the National Academy of Sciences of the United States of America, vol. 113, pp. E2306 - E2315, http://dx.doi.org/10.1073/pnas.1518244113
    Journal articles | 2015
    Tursky ML; Beck D; Thoms JAI; Huang Y; Kumari A; Unnikrishnan A; Knezevic K; Evans K; Richards LA; Lee E; Morris J; Goldberg L; Izraeli S; Wong JWH; Olivier J; Lock RB; MacKenzie KL; Pimanda JE, 2015, 'Overexpression of ERG in cord blood progenitors promotes expansion and recapitulates molecular signatures of high ERG leukemias', Leukemia, vol. 29, pp. 819 - 827, http://dx.doi.org/10.1038/leu.2014.299
    Journal articles | 2014
    Ju YSE; Alexandrov LB; Gerstung M; Martincorena I; Nik-Zainal S; Ramakrishna M; Davies HR; Papaemmanuil E; Gundem G; Shlien A; Bolli N; Behjati S; Tarpey PS; Nangalia J; Massie CE; Butler AP; Teague JW; Vassiliou GS; Green AR; Du MQ; Unnikrishnan A; Pimanda JE; Teh BTE; Munshi N; Greaves M; Vyas P; El-Naggar AK; Santarius T; Collins VP; Grundy R; Taylor JA; Hayes DN; Malkin D; Foster CS; Warren AY; Whitaker HC; Brewer D; Eeles R; Cooper C; Neal D; Visakorpi T; Isaacs WB; Bova GS; Flanagan AM; Futreal PA; Lynch AG; Chinnery PF; McDermott U; Stratton MR; Campbell PJ, 2014, 'Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer', eLife, vol. 3, http://dx.doi.org/10.7554/eLife.02935
    Journal articles | 2013
    Beck D; Thoms JAI; Perera D; Schütte J; Unnikrishnan A; Knezevic K; Kinston SJ; Wilson NK; O'Brien TA; Göttgens B; Wong JWH; Pimanda JE, 2013, 'Genome-wide analysis of transcriptional regulators in human HSPCs reveals a densely interconnected network of coding and noncoding genes', Blood, vol. 122, pp. e12 - e22, http://dx.doi.org/10.1182/blood-2013-03-490425
    Journal articles | 2012
    Unnikrishnan A; Akiyoshi B; Biggins S; Tsukiyama T, 2012, 'An efficient purification system for native minichromosome from Saccharomyces cerevisiae', Methods in Molecular Biology, vol. 833, pp. 115 - 123, http://dx.doi.org/10.1007/978-1-61779-477-3_8
    Journal articles | 2010
    Unnikrishnan A; Gafken PR; Tsukiyama T, 2010, 'Dynamic changes in histone acetylation regulate origins of DNA replication', Nature Structural & Molecular Biology, vol. 17, pp. 430 - 437, http://dx.doi.org/10.1038/nsmb.1780
  • Preprints | 2020
    Liu Y-C; Fabiani E; Kwon J; Gao C; Falconi G; Valentini L; Gurnari C; Liu YV; Jones AI; Yang J; Yang H; Thoms JAI; Unnikrishnan A; Pimanda JE; Pan R; Voso MT; Tenen DG; Chai L, 2020, Demethylation and upregulation of an oncogene post hypomethylating treatment, http://dx.doi.org/10.1101/2020.07.21.20157776
    Preprints | 2020
    Yang J; Gao C; Liu M; Chen Z; Liu Y-C; Kwon J; Qi J; Tian X; Stein A; Liu Y; Kong NR; Wu Y; Yin S; Xi JJ; Luo H; Silberstein LE; Thoms JAI; Unnikrishnan A; Pimanda JE; Tenen DG; Chai L, 2020, Induction of a SALL4-dependency for targeted cancer therapy, http://dx.doi.org/10.1101/2020.07.10.197434

My Research Supervision

Postdoctoral researchers:

Dr. Govardhan Anande

 

Higher Degree Students:

Dr. Lachlin Vaughan (Haematologist, PhD Student)

Newton Amaldoss (UNSW Scientia PhD Student)

Onkar Mulay (Masters Student)

 

Undergraduate Students:

Rohan Barar (Undergraduate Medical Student, Honours)

Beau Jesser (School of Medical Sciences, Honours)

Jungmin Ryu (School of Medical Sciences, Honours)

 

Research Staff:

Mangalangi Udayakumar

Lizzie Richardson