Dr Bill   Giannakopoulos
Senior Lecturer

Dr Bill Giannakopoulos

medicine-health
St. George Clin Sch- Operating

Dr Bill Giannakopoulos is a Clinical Academic Senior Lecturer at the St George & Sutherland Clinical School located at St George Hospital, Kogarah.

Research Interests:
Systemic lupus erythematousus (SLE) is the prototypical autoimmune disease. Patients have a significant risk of death at a young age attributed to thrombosis, and infection related to immunosuppression. My research interests span the areas of basic science and clinical epidemiology, looking at understanding the contributing factors to the elevated risk of thrombosis in the SLE setting, and developing novel laboratory tests which will allow clinicians to accurately risk stratify patients at high risk of thrombosis and death. This has major clinical implications for preventative treatment strategies. My group's major focus is specifically on the pathophysiolgical mechanisms by which antiphospholipid antibodies, which have a high prevalence in the SLE setting are associated with elevated risk of thrombosis. We are also actively exploring the pathogenic mechanisms, using novel murine models of SLE, to understand how antiphospholipid antibodies are generated, and why they are closely linked with the autoantibodies more typical of SLE.

Broad Research Areas:
Arthritis / Rheumatology, Immunology, Inflammation, Lipids, Cardiology and Vascular Disease

Qualifications:
BSc(Med) MBBS PhD

Society Memberships & Professional Activities:
Fellow of The Royal Australian College of Physicians, Member of the Australian Rheumatology Association

Specific Research Keywords:
Autoimmune Disease, Animal Models, Vascular Biology, Thrombosis, Cardiology and Vascular Disease

Phone
9113 1855 or 9113 2139

Publications

  • Book Chapters | 2019
    Dr Bill Giannakopoulos
    Qi M; Weaver JC; Rahgozar S; Giannakopoulos B; Krilis SA, 2019, 'Quantitation of total and free thiol angiotensinogen as a prognostic marker for preeclampsia', in Functional Disulphide Bonds : Methods and Protocols, pp. 285 - 293, http://dx.doi.org/10.1007/978-1-4939-9187-7_18
    Book Chapters | 2019
    Dr Bill Giannakopoulos
    Qi M; Weaver JC; Krilis SA; Giannakopoulos B, 2019, 'Quantitation of total and free Thiol β2-Glycoprotein I levels for diagnostic and prognostic purposes in the antiphospholipid syndrome', in Functional Disulphide Bonds : Methods and Protocols, pp. 275 - 283, http://dx.doi.org/10.1007/978-1-4939-9187-7_17
    Book Chapters | 2017
    Dr Bill Giannakopoulos
    de Groot PG; de Laat B; Rand J; Vlachoyiannopoulos PG; El-Assaad F; Krilis SA; Giannakopoulos B, 2017, 'Natural Proteins Involved in Antiphospholipid Syndrome', in Antiphospholipid Syndrome, Springer International Publishing, pp. 15 - 27, http://dx.doi.org/10.1007/978-3-319-55442-6_2
    Book Chapters | 2007
    Dr Bill Giannakopoulos
    Giannakopoulos B; Yan XK; Krilis S, 2007, 'Antibodies and their antigenic targets in the antiphospholipid syndrome', in Murphy K; Ray M (ed.), A Companion to Rheumatology: Systemic Lupus Erythematosus, Mosby Elsevier, USA, pp. 233 - 240, http://dx.doi.org/10.1016/B978-0-323-04434-9.50028-2
    Book Chapters | 2007
    Dr Bill Giannakopoulos
    Giannakopoulos B; Yan X; Krilis SA, 2007, 'Chapter 22B Antibodies and their Antigenic Targets in the Antiphospholipid Syndrome', in Systemic Lupus Erythematosus, pp. 233 - 240, http://dx.doi.org/10.1016/b978-0-323-04434-9.50028-2
  • Journal articles | 2021
    Dr Bill Giannakopoulos
    Krilis M; Qi M; Ioannou Y; Zhang JY; Ahmadi Z; Wong JWH; Vlachoyiannopoulos PG; Moutsopoulos HM; Koike T; Sturgess AD; Chong BH; Krilis SA; Giannakopoulos B, 2021, 'Clinical relevance of nitrated beta 2-glycoprotein I in antiphospholipid syndrome: Implications for thrombosis risk', Journal of Autoimmunity, vol. 122, pp. 102675, http://dx.doi.org/10.1016/j.jaut.2021.102675
    Journal articles | 2020
    Dr Bill Giannakopoulos
    Weaver JC; Ullah I; Qi M; Giannakopoulos B; Rye KA; Kockx M; Kritharides L; Krilis SA, 2020, 'Free thiol β2-GPI (β-2-glycoprotein-I) provides a link between inflammation and oxidative stress in atherosclerotic coronary artery disease', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 40, pp. 2794 - 2804, http://dx.doi.org/10.1161/ATVBAHA.120.315156
    Journal articles | 2018
    Dr Bill Giannakopoulos
    Krilis M; Qi M; Qi J; Wong JWH; Guymer R; Liew G; Hunyor AP; Madigan M; McCluskey P; Weaver J; Krilis SA; Giannakopoulos B, 2018, 'Dual roles of different redox forms of complement factor H in protecting against age related macular degeneration', Free Radical Biology and Medicine, vol. 129, pp. 237 - 246, http://dx.doi.org/10.1016/j.freeradbiomed.2018.09.034
    Journal articles | 2018
    Dr Bill Giannakopoulos
    Weaver JC; Krilis SA; Giannakopoulos B, 2018, 'Oxidative post-translational modification of βeta 2-glycoprotein I in the pathophysiology of the anti-phospholipid syndrome', Free Radical Biology and Medicine, vol. 125, pp. 98 - 103, http://dx.doi.org/10.1016/j.freeradbiomed.2018.03.048
    Journal articles | 2017
    Dr Bill Giannakopoulos
    Ullah I; Qi M; Qi J; Giannakopoulos B; Weaver J; Krilis S, 2017, 'Development of Novel Assays for Quantitation of Total and Free Thiol Beta 2 Glycoprotein I', Heart, Lung and Circulation, vol. 26, pp. S55 - S55, http://dx.doi.org/10.1016/j.hlc.2017.06.027
    Journal articles | 2017
    Dr Bill Giannakopoulos
    El-Assaad F; Qi M; Gordon AK; Qi J; Dong S; Passam F; Weaver JC; Giannakopoulos B; Krilis SA, 2017, 'Βeta 2-glycoprotein i protects mice against gram-negative septicaemia in a sexually dimorphic manner', Scientific Reports, vol. 7, http://dx.doi.org/10.1038/s41598-017-07945-8
    Journal articles | 2017
    Dr Bill Giannakopoulos
    Dong S; Qi M; Wang Y; Chen L; Weaver JC; Krilis SA; Giannakopoulos B, 2017, 'β2GPI exerts an anti-obesity effect in female mice by inhibiting lipogenesis and promoting lipolysis', Oncotarget, vol. 8, pp. 92652 - 92666, http://dx.doi.org/10.18632/oncotarget.21536
    Journal articles | 2017
    Dr Bill Giannakopoulos
    Krilis M; Qi M; Madigan MC; Wong JWH; Abdelatti M; Guymer RH; Whitelock J; McCluskey P; Zhang P; Qi J; Hunyor AP; Krilis SA; Giannakopoulos B, 2017, 'Nitration of tyrosines in complement factor H domains alters its immunological activity and mediates a pathogenic role in age related macular degeneration', Oncotarget, vol. 8, pp. 49016 - 49032, http://dx.doi.org/10.18632/oncotarget.14940
    Journal articles | 2016
    Dr Bill Giannakopoulos
    Zhou S; Tanaka K; O'Keeffe M; Qi M; El-Assaad F; Weaver JC; Chen G; Weatherall C; Wang Y; Giannakopoulos B; Chen L; Yu DM; Hamilton MJ; Wensing LA; Stevens RL; Krilis SA, 2016, 'CD117+ dendritic and mast cells are dependent on RasGRP4 to function as accessory cells for optimal natural killer cell-mediated responses to lipopolysaccharide', PLoS ONE, vol. 11, http://dx.doi.org/10.1371/journal.pone.0151638
    Journal articles | 2016
    Dr Bill Giannakopoulos
    Zhang P; Weaver JC; Chen G; Beretov J; Atsumi T; Qi M; Bhindi R; Qi JC; Madigan MC; Giannakopoulos B; Krilis SA, 2016, 'The fifth domain of beta 2 glycoprotein I protects from natural IgM mediated cardiac ischaemia reperfusion injury', PLoS ONE, vol. 11, http://dx.doi.org/10.1371/journal.pone.0152681
    Journal articles | 2016
    Dr Bill Giannakopoulos
    Qi M; Abdelatti M; Krilis M; Madigan MC; Weaver J; Guymer RH; McCluskey P; Wang Y; Zhou S; Krilis SA; Giannakopoulos B, 2016, 'Do Beta 2-Glycoprotein i Disulfide Bonds Protect the Human Retina in the Setting of Age-Related Macular Degeneration?', Antioxidants and Redox Signaling, vol. 24, pp. 32 - 38, http://dx.doi.org/10.1089/ars.2014.6052
    Journal articles | 2016
    Dr Bill Giannakopoulos
    El-Assaad F; Krilis SA; Giannakopoulos B, 2016, 'Posttranslational forms of beta 2-glycoprotein I in the pathogenesis of the antiphospholipid syndrome', Thrombosis Journal, vol. 14, http://dx.doi.org/10.1186/s12959-016-0115-z
    Journal articles | 2016
    Dr Bill Giannakopoulos
    Zhou S; Chen G; Qi M; El-Assaad F; Wang Y; Dong S; Chen L; Yu D; Weaver JC; Beretov J; Krilis SA; Giannakopoulos B, 2016, 'Gram negative bacterial inflammation ameliorated by the plasma protein beta 2-Glycoprotein I', Scientific Reports, vol. 6, http://dx.doi.org/10.1038/srep33656
    Journal articles | 2015
    Dr Bill Giannakopoulos
    Rahgozar S; Amirian T; Qi M; Shahshahan Z; Entezar-E-Ghaem M; Tehrani HG; Miroliaei M; Krilis SA; Giannakopoulos B, 2015, 'Improved assay for quantifying a redox form of angiotensinogen as a biomarker for pre-eclampsia: A case-control study', PLoS ONE, vol. 10, http://dx.doi.org/10.1371/journal.pone.0135905
    Journal articles | 2014
    Dr Bill Giannakopoulos
    Krilis SA; Giannakopoulos B, 2014, 'Laboratory methods to detect antiphospholipid antibodies', Hematology (United States), vol. 2014, pp. 321 - 328, http://dx.doi.org/10.1182/asheducation-2014.1.321
    Journal articles | 2014
    Dr Bill Giannakopoulos
    Giannakopoulos B; Mirarabshahi P; Qi M; Weatherall C; Qi JC; Tanaka K; Millar E; Vonthethoff L; Gatto D; Spielman D; Krilis SA, 2014, 'Deletion of the antiphospholipid syndrome autoantigen β2- glycoprotein i potentiates the lupus autoimmune phenotype in a toll-like receptor 7-mediated murine model', Arthritis and Rheumatology, vol. 66, pp. 2270 - 2280, http://dx.doi.org/10.1002/art.38646
    Journal articles | 2014
    Dr Bill Giannakopoulos
    Giannakopoulos B; Krilis S, 2014, 'In APS, two A1's are better than one!', Blood, vol. 123, pp. 955 - 956, http://dx.doi.org/10.1182/blood-2013-12-542506
    Journal articles | 2013
    Dr Bill Giannakopoulos
    Giannakopoulos B; Krilis S, 2013, 'The Pathogenesis of the Antiphospholipid Syndrome', New England Journal of Medicine, vol. 368, pp. 1033 - 1044, http://dx.doi.org/10.1056/NEJMra1112830
    Journal articles | 2013
    Dr Bill Giannakopoulos
    Krilis M; Mao Q; Madigan M; Wong J; Abulatti M; Guymer R; McCluskey P; Zhang P; Qi J; Krilis S; Giannakopoulos B, 2013, 'POST TRANSLATIONALLY MODIFIED COMPLEMENT FACTOR H IN AGE RELATED MACULAR DEGENERATION', CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, vol. 41, pp. 17 - 17, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000329507100022&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 2012
    Dr Bill Giannakopoulos
    Giannakopoulos B; Gao L; Qi M; Wong JW; Yu D; Vlachoyiannopoulos P; Moutsopoulos HM; Atsumi T; Koike T; Hogg PJ; Qi JC; Krilis S, 2012, 'Factor XI is a substrate for oxidoreductases: Enhanced activation of reduced FXI and its role in antiphospholipid syndrome thrombosis.', Journal of Autoimmunity, vol. 39, pp. 121 - 129, http://dx.doi.org/10.1016/j.jaut.2012.05.005
    Journal articles | 2011
    Dr Bill Giannakopoulos
    Passam F; Rahgozar S; Qi M; Raftery MJ; Wong JWH; Tanaka K; Ioannou Y; Zhang JY; Gemmell R; Qi JC; Giannakopoulos B; Hughes WE; Hogg PJ; Krilis S, 2011, 'Redox control of â2-glycoprotein I-von Willebrand factor interaction by thioredoxin-1.', Journal of Thrombosis and Haemostasis, vol. 8, pp. 1754 - 1762, http://dx.doi.org/10.1111/j.1538-7836.2010.03944.x
    Journal articles | 2011
    Dr Bill Giannakopoulos
    Giannakopoulos B; Mirarabshahi P; Krilis S, 2011, 'New insights into the biology and pathobiology of beta2-glycoprotein I.', Current Rheumatology Reports, vol. 13, pp. 90 - 95, http://dx.doi.org/10.1007/s11926-010-0151-9
    Journal articles | 2011
    Dr Bill Giannakopoulos
    Krilis S; Passam F; Giannakopoulos B; Mirarabshahi P, 2011, 'Molecular pathophysiology of the antiphospholipid syndrome: the role of oxidative posttranslational modification of beta 2 glycoprotein I', JOURNAL OF THROMBOSIS AND HAEMOSTASIS, vol. 9, pp. 715 - 715, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000208992803015&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 2010
    Dr Bill Giannakopoulos
    Passam F; Rahgozar S; Qi M; Raftery MJ; Wong J; Tanaka K; Ioannou Y; Zhang JY; Gemmell R; Qi JC; Giannakopoulos B; Hughes WE; Hogg PJ; Krilis S, 2010, 'Beta 2 glycoprotein I is a substrate of thiol oxidoreductases', Blood, vol. 116, pp. 1995 - 1997, http://dx.doi.org/10.1182/blood-2010-02-271494
    Journal articles | 2010
    Dr Bill Giannakopoulos
    Ioannou Y; Zhang JY; Passam FH; Rahgozar S; Qi JC; Giannakopoulos B; Qi M; Yu P; Yu DM; Hogg PJ; Krilis SA, 2010, 'Naturally occurring free thiols within β2-glycoprotein I in vivo: Nitrosylation, redox modification by endothelial cells, and regulation of oxidative stress-induced cell injury', Blood, vol. 116, pp. 1961 - 1970, http://dx.doi.org/10.1182/blood-2009-04-215335
    Journal articles | 2009
    Dr Bill Giannakopoulos
    Krilis S; Giannakopoulos B; Passam F; Ioannou Y, 2009, 'How we diagnose the antiphospholipid syndrome', Blood, vol. 113, pp. 985 - 994, http://dx.doi.org/10.1182/blood-2007-12-129627
    Journal articles | 2009
    Dr Bill Giannakopoulos
    Giannakopoulos B; Krilis S, 2009, 'How I treat the antiphospholipid syndrome', Blood, vol. 114, pp. 2020 - 2030, http://dx.doi.org/10.1182/blood-2009-05-220756
    Journal articles | 2009
    Dr Bill Giannakopoulos
    Reed J; Giannakopoulos B; Jackson M; Krilis S; Gordon T, 2009, 'Ro 60 functions as a receptor for β2-glycoprotein I on apoptotic cells', Arthritis Care & Research, vol. 60, pp. 860 - 869, http://dx.doi.org/10.1002/art.24361
    Journal articles | 2009
    Dr Bill Giannakopoulos
    Krilis S; Reed J; Giannakopoulos B; Jackson M; Gordon T, 2009, 'Ro60 Functions as a receptor for B2-glycoprotein I on apoptotic cells', Arthritis Care & Research, vol. 60, pp. 985 - 994
    Journal articles | 2008
    Dr Bill Giannakopoulos
    Rahgozar S; Giannakopoulos B; Yan X; Wei J; Jian CQ; Gemmell R; Krilis SA, 2008, 'Beta2-glycoprotein I protects thrombin from inhibition by heparin cofactor II: Potentiation of this effect in the presence of anti-β2-glycoprotein I autoantibodies', Arthritis and Rheumatism, vol. 58, pp. 1146 - 1155, http://dx.doi.org/10.1002/art.23387
    Journal articles | 2008
    Dr Bill Giannakopoulos
    Krilis S; Rahgozar S; Giannakopoulos B; Qi JC; Gemmell R; Yan X; Wei J, 2008, 'Beta2- Glycoprotein I Protects Thrombin from Inhibition by Heparin Cofactor II', Arthritis Care & Research, vol. 58, pp. 1146 - 1155
    Journal articles | 2007
    Dr Bill Giannakopoulos
    Giannakopoulos B; Passam F; Rahgozar S; Krilis S, 2007, 'Current concepts on the pathogenesis of the antiphospholipid syndrome', Blood, vol. 109, pp. 422 - 430, http://dx.doi.org/10.1182/blood-2006-04-001206
    Journal articles | 2007
    Dr Bill Giannakopoulos
    Giannakopoulos B; Shi T; Yan XK; Yu P; Berndt MC; Andrew R; Rivera J; Iverson GM; Cockerill KA; Linnik MD; Krilis S, 2007, 'Anti-beta(2)-glycoprotein I antibodies in complex with beta(2)-glycoprotein I can activate platelets via glycoprotein Ib-IX-V', Clinical and Experimental Rheumatology, vol. 25, pp. 159 - 160, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000246882200181&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
    Journal articles | 2007
    Dr Bill Giannakopoulos
    Rahgozar S; Yang Q; Giannakopoulos B; Yan X; Miyakis S; Krilis SA, 2007, 'Beta2-glycoprotein I binds thrombin via exosite I and exosite II: Anti-β2-glycoprotein I antibodies potentiate the inhibitory effect of β2-glycoprotein I on thrombin-mediated factor XIa generation', Arthritis and Rheumatism, vol. 56, pp. 605 - 613, http://dx.doi.org/10.1002/art.22367
    Journal articles | 2007
    Dr Bill Giannakopoulos
    Rahgozar S; Yang Q; Giannakopoulos B; Yan XK; Miyakis S; Krilis S, 2007, 'Beta(2)-glycoprotein I binds thrombin via exosite I and exosite II Anti-beta(2)-glycoprotein I antibodies potentiate the inhibitory effect of beta(2)-glycoprotein I on thrombin-mediated factor XIa generation', Arthritis Care & Research, vol. 56, pp. 605 - 613, http://dx.doi.org/10.1002/art.22367
    Journal articles | 2006
    Dr Bill Giannakopoulos
    Shi T; Giannakopoulos B; Yan XK; Yu P; Berndt MC; Andrews RK; Rivera J; Iverson M; Cockerill KA; Linnik MD; Krilis S, 2006, 'Anti-Beta2-Glycoprotein I Antibodies in Complex With Beta2-Glycoprotein I Can Activate Platelets in a Dysregulated Manner Via Glycoprotein Ib-IX-V', Arthritis Care & Research, vol. 54, pp. 2558 - 2567, http://dx.doi.org/10.1002/art.21968
    Journal articles | 2006
    Dr Bill Giannakopoulos
    Shi T; Giannakopoulos B; Yan X; Yu P; Berndt MC; Andrews RK; Rivera J; Iverson GM; Cockerill KA; Linnik MD; Krilis SA, 2006, 'Anti-β2-glycoprotein I antibodies in complex with β2-glycoprotein I can activate platelets in a dysregulated manner via glycoprotein Ib-IX-V', Arthritis and Rheumatism, vol. 54, pp. 2558 - 2567, http://dx.doi.org/10.1002/art.21968
    Journal articles | 2005
    Dr Bill Giannakopoulos
    Shi T; Giannakopoulos B; Iverson M; Cockerill KA; Linnik MD; Krilis S, 2005, 'Domain V of B2-Glycoprotein I Binds Factor XI/XIa and Is Cleaved of Lys317-Thr318', The Journal of Biological Chemistry, vol. 280, pp. 907 - 912, http://dx.doi.org/10.1074/jbc.M410291200
    Journal articles | 2004
    Dr Bill Giannakopoulos
    Miyakis S; Giannakopoulos B; Krilis S, 2004, 'Beta 2-Glycoprotein I-function in health and disease', Thrombosis Research, vol. 114, pp. 335 - 346, http://dx.doi.org/10.1016/j.thromres.2004.07.017
    Journal articles | 2004
    Dr Bill Giannakopoulos
    Yang Q; Shi T; Cheyne B; Giannakopoulos B; Krilis S, 2004, 'Anti-beta(2) glycoprotein I antibodies potentiate the inhibitory effects of beta(2)glycoprotein I on the activation of FXI by FIIa: Effect of clipped beta(2) glycoprotein I', Thrombosis Research, vol. 114, pp. 608 - 608, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000228015200055&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
  • Conference Abstracts | 2016
    Dr Bill Giannakopoulos
    El-Assaad F; Gordon KA; Zhou S; Qi M; Beretov J; Chen G; Giannakopoulos B; Krilis S, 2016, 'Gender dimorphism in the immunomodulatory role of beta eta 2-glycoprotein I in sepsis', in EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY-BLACKWELL, Melbourne, AUSTRALIA, Vol. 46, pp. 104 - 104, presented at International Congress of Immunology (ICI), Melbourne, AUSTRALIA, 21 August 2016 - 26 August 2016, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000383610400207&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2016
    Dr Bill Giannakopoulos
    Chen G; Weaver JC; Zhang P; Beretov J; Tatsuya A; Qi M; Bhindi R; Qi JC; Madigan MC; Giannakopoulos B; Krilis SA, 2016, 'BETA 2 GLYCOPROTEIN I PEPTIDE PROTECTS FROM CARDIAC ISCHEMIA REPERFUSION INJURY IN MICE', in CARDIOLOGY, KARGER, pp. 112 - 112, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000383053200100&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2010
    Dr Bill Giannakopoulos
    Ioannou Y; Zhang J-Y; Passam FH; Rahgozar S; Qi JC; Giannakopoulos B; Qi M; Yu P; Yu D; Hogg PJ; Krilis S, 2010, 'HUMAN ENDOTHELIAL CELLS SECRETE OXIDOREDUCTASES ON THE CELL SURFACE AND CAN BOTH NITROSYLATE AND MODULATE THE REDOX STATE OF beta 2-GLYCOPROTEIN I', in RHEUMATOLOGY, OXFORD UNIV PRESS, Birmingham, ENGLAND, pp. I120 - I120, presented at Annual Meeting of the British-Society-Rheumatology/Spring Meeting of British-Health-Professional-in-Rheumatology, Birmingham, ENGLAND, 21 April 2010 - 23 April 2010, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000276047500304&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2010
    Dr Bill Giannakopoulos
    Ioannou Y; Zhang J-Y; Passam FH; Rahgozar S; Qi JC; Giannakopoulos B; Qi M; Yu P; Yu DM; Hogg PJ; Krilis SA, 2010, 'NATURALLY OCCURRING FREE THIOLS WITHIN beta 2-GLYCOPROEIN I IN VIVO: FUNCTIONAL IMPLICATIONS IN THE REGULATION OF OXIDATIVE STRESS INDUCED ENDOTHELIAL CELL INJURY', in RHEUMATOLOGY, OXFORD UNIV PRESS, Birmingham, ENGLAND, pp. I30 - I30, presented at Annual Meeting of the British-Society-Rheumatology/Spring Meeting of British-Health-Professional-in-Rheumatology, Birmingham, ENGLAND, 21 April 2010 - 23 April 2010, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000276047500072&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2010
    Dr Bill Giannakopoulos
    Qi M; Passam F; Qi JC; Giannakopoulos B; Krilis S, 2010, 'Participation of reduced beta 2 glycoprotein I by thioredoxin-1 (TRX-1) in the regulation of platelet adhesion through binding of von Willebrand factor in a thiol dependent manner', in Hughes GRV (ed.), Lupus, SAGE Publications, London, England, pp. 500 - 500, presented at 13th International Congress on Antiphospholipid Antibodies, Galveston, Texas US, 13 April 2010 - 16 April 2010
    Conference Papers | 2010
    Dr Bill Giannakopoulos
    Giannakopoulos B; Rahgozar S; Passam F; Gemmell R; Qi M; Qi JC; Krilis S, 2010, 'Reduction of Beta 2 glycoprotein I by thioredoxin-1 promotes binding to von Willebrand factor', in Hughes GRV (ed.), Lupus, SAGE Publications, London, England, pp. 504 - 504, presented at 13th International Congress on Antiphospholipid Antibodies, Galveston, Texas US, 13 April 2010 - 16 April 2010
    Conference Papers | 2010
    Dr Bill Giannakopoulos
    Ioannou Y; Zhang JY; Passam F; Rahgozar S; Qi JC; Giannakopoulos B; Qi M; Yu P; Yu D; Hogg PJ; Krilis S, 2010, 'Human endothelial cells secrete oxidoreductases on the cell surface and can both nitrosylate and modulate the redox state of Beta 2 glycoprotein I', in Hughes GRV (ed.), Lupus, SAGE Publications, London, England, pp. 503 - 503, presented at 13th International Congress on Antiphospholipid Antibodies, Galveston, Texas US, 13 April 2010 - 16 April 2010
    Conference Papers | 2010
    Dr Bill Giannakopoulos
    Giannakopoulos B; Qi JC; Qi M; Matthaei K; Rye KA; Krilis S, 2010, 'Beta 2 glycoprotein I directly modulates the level of plasma cholesterol in-vivo', in Hughes GRV (ed.), Lupus, SAGE Publications, London, England, pp. 503 - 503, presented at 13th International Congress on Antiphospholipid Antibodies, Galveston, Texas US, 13 April 2010 - 16 April 2010
    Conference Papers | 2010
    Dr Bill Giannakopoulos
    Ioannou Y; Zhang JY; Passam F; Rahgozar S; Qi JC; Giannakopoulos B; Qi M; Yu P; Yu D; Hogg PJ; Krilis S, 2010, 'Naturally occurring free thiols within Beta 2 glycoprotein I in-vivo: functional implications in the regulation of oxidative stress induced endothelial cell injury', in Hughes GRV (ed.), Lupus, SAGE Publications, London, England, pp. 502 - 502, presented at 13th International Congress on Antiphospholipid Antibodies, Galveston, Texas US, 13 April 2010 - 16 April 2010, http://bloodjournal.hematologylibrary.org/cgi/content/abstract/116/11/1961
    Conference Papers | 2008
    Dr Bill Giannakopoulos
    Reed J; Giannakopoulos B; Jackson M; Krilis S; Gordon T, 2008, 'Ro60 functions as a receptor for beta2-glycoprotein I on apoptotic cells', in Arthritis Care & Research, John Wiley & Sons, Inc., United States, pp. S612 - S612, presented at Association-of-Rheumatology-Health-Professionals, San Francisco, California USA, 24 October 2008 - 29 October 2008, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000259244202616&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
    Conference Papers | 2004
    Dr Bill Giannakopoulos
    Bester C; Shi T; Yang Q; Giannakopoulos B; Iverson GM; Qi JC; Cokerill KA; Linnik MD; Konecny P; Krilis SA, 2004, 'B-2-glycoprotein I binds factor XI and inhibits its activation by thrombin and factor XIIA: Loss of inhibition by clipped B-2-glycoprotein I', in THROMBOSIS RESEARCH, PERGAMON-ELSEVIER SCIENCE LTD, Sydney, AUSTRALIA, pp. 609 - 609, presented at 11th International Congress on Antiphospholipid Antibodies, Sydney, AUSTRALIA, 14 November 2004 - 18 November 2004, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000228015200057&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Awards

Grants

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