Associate Professor Carsten   Schmitz-Peiffer
Conjoint Associate Professor

Associate Professor Carsten Schmitz-Peiffer

BA (Natural Sciences) Cambridge, UK

PhD (Biochemistry) Bristol, UK

medicine-health
St Vincent's Clinical School

Research Interests:
The development of insulin resistance in skeletal muscle and liver is a key feature in the pathogenesis of type 2 diabetes. Insulin resistance is strongly associated with increased lipid availability, although the precise mechanisms involved remain to be elucidated. The Insulin Signalling Group at the Garvan Institute employs animal and cell culture models to study lipid metabolism and the inhibitory signalling pathways initiated by lipids which interfere with normal insulin action, with an interest in crosstalk between different tissues such as adipose tissue, the brain and liver. We are also developing small molecules inhibitors against a target we have identified in the development of glucose intolerance.

Broad Research Areas:
Diabetes, Obesity, Biochemistry, Metabolism, Proteomics

Qualifications:
BA (Natural Sciences) Cambridge, UK; PhD (Biochemistry) Bristol, UK

Specific Research Keywords:
Type 2 diabetes, Signalling and Transcription, Endocrinology, Molecular Mechanisms, Cell Metabolism

Phone
02 9295 8212
Location
Diabetes and Metabolism Division Level 6, Garvan Institute 384 Victoria Street DARLINGHURST NSW 2010

Publications

  • Journal articles | 2020
    Associate Professor Carsten Schmitz-Peiffer
    Schmitz-Peiffer C, 2020, 'Deconstructing the Role of PKC Epsilon in Glucose Homeostasis', Trends in Endocrinology and Metabolism, vol. 31, pp. 344 - 356, http://dx.doi.org/10.1016/j.tem.2020.01.016
    Journal articles | 2020
    Associate Professor Carsten Schmitz-Peiffer
    Schmitz-Peiffer C, 2020, 'PKC is not a one-trick pony. Invited Comment on CrossTalk 47: ‘Intramuscular lipid accumulation causes insulin resistance’', The Journal of Physiology, vol. 598, pp. 3813 - 3814, http://dx.doi.org/10.1113/JP279715
    Journal articles | 2019
    Associate Professor Carsten Schmitz-Peiffer
    Brandon AE; Liao BM; Diakanastasis B; Parker BL; Raddatz K; McManus SA; O'Reilly L; Kimber E; van der Kraan AG; Hancock D; Henstridge DC; Meikle PJ; Cooney GJ; James DE; Reibe S; Febbraio MA; Biden TJ; Schmitz-Peiffer C, 2019, 'Protein Kinase C Epsilon Deletion in Adipose Tissue, but Not in Liver, Improves Glucose Tolerance', Cell Metabolism, vol. 29, pp. 183 - 191.e7, http://dx.doi.org/10.1016/j.cmet.2018.09.013
    Journal articles | 2018
    Associate Professor Carsten Schmitz-Peiffer
    Schmitz-Peiffer C, 2018, 'Anarchy in the UPR: A Ca2+-insensitive PKC inhibits SERCA activity to promote ER stress', Bioscience Reports, vol. 38, http://dx.doi.org/10.1042/BSR20170966
    Journal articles | 2018
    Associate Professor Carsten Schmitz-Peiffer
    Chandrashekaran IR; Norton RS; Schmitz-Peiffer C, 2018, 'Characterisation of peptide interactions that regulate PKCε activation', FEBS Letters, vol. 592, pp. 179 - 189, http://dx.doi.org/10.1002/1873-3468.12953
    Journal articles | 2018
    Associate Professor Carsten Schmitz-Peiffer
    Turner N; Lim XY; Toop HD; Osborne B; Brandon AE; Taylor EN; Fiveash CE; Govindaraju H; Teo JD; McEwen HP; Couttas TA; Butler SM; Das A; Kowalski GM; Bruce CR; Hoehn KL; Fath T; Schmitz-Peiffer C; Cooney GJ; Montgomery MK; Morris JC; Don AS, 2018, 'A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism', Nature Communications, vol. 9, http://dx.doi.org/10.1038/s41467-018-05613-7
    Journal articles | 2017
    Associate Professor Carsten Schmitz-Peiffer
    Hayward B; Molero JC; Windmill K; Sanigorski A; Weir J; McRae NL; Aston-Mourney K; Osborne B; Liao B; Walder KR; Meikle PJ; Konstantopoulos N; Schmitz-Peiffer C, 2017, 'Pathways of Acetyl-CoA Metabolism Involved in the Reversal of Palmitate-Induced Glucose Production by Metformin and Salicylate', Experimental and Clinical Endocrinology and Diabetes, vol. 124, pp. 602 - 612, http://dx.doi.org/10.1055/s-0042-111516
    Journal articles | 2016
    Associate Professor Carsten Schmitz-Peiffer
    Liao BM; McManus SA; Hughes WE; Schmitz-Peiffer C, 2016, 'Flavin-containing monooxygenase 3 reduces endoplasmic reticulum stress in lipid-treated hepatocytes', Molecular Endocrinology, vol. 30, pp. 417 - 428, http://dx.doi.org/10.1210/me.2015-1217
    Journal articles | 2016
    Associate Professor Carsten Schmitz-Peiffer
    Montgomery MK; Brown SHJ; Lim XY; Fiveash CE; Osborne B; Bentley NL; Braude JP; Mitchell TW; Coster ACF; Don AS; Cooney GJ; Schmitz-Peiffer C; Turner N, 2016, 'Regulation of glucose homeostasis and insulin action by ceramide acyl-chain length: A beneficial role for very long-chain sphingolipid species', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, vol. 1861, pp. 1828 - 1839, http://dx.doi.org/10.1016/j.bbalip.2016.08.016
    Journal articles | 2014
    Associate Professor Carsten Schmitz-Peiffer
    Liao BM; Raddatz K; Zhong L; Parker BL; Raftery MJ; Schmitz-Peiffer C, 2014, 'Proteomic analysis of livers from fat-fed mice deficient in either PKCδ or PKCε identifies Htatip2 as a regulator of lipid metabolism', Proteomics, vol. 14, pp. 2578 - 2587, http://dx.doi.org/10.1002/pmic.201400202
    Journal articles | 2013
    Associate Professor Carsten Schmitz-Peiffer
    Frangioudakis G; Diakanastasis B; Liao BQM; Saville JT; Hoffman NJ; Mitchell TW; Schmitz-Peiffer C, 2013, 'Ceramide accumulation in L6 skeletal muscle cells due to increased activity of ceramide synthase isoforms has opposing effects on insulin action to those caused by palmitate treatment', Diabetologia, vol. 56, pp. 2697 - 2701, http://dx.doi.org/10.1007/s00125-013-3035-5
    Journal articles | 2013
    Associate Professor Carsten Schmitz-Peiffer
    Schmitz-Peiffer C, 2013, 'The tail wagging the dog - Regulation of lipid metabolism by protein kinase C', FEBS Journal, vol. 280, pp. 5371 - 5383, http://dx.doi.org/10.1111/febs.12285
    Journal articles | 2013
    Associate Professor Carsten Schmitz-Peiffer
    Lismaa SE; Aplin M; Holman S; Yiu T; Jackson K; Burchfield JG; Mitchell CJ; O'Reilly L; Davenport A; Cantley J; Schmitz-Peiffer C; Biden TJ; Cooney GJ; Graham RM, 2013, 'Glucose Homeostasis in Mice Is Transglutaminase 2 Independent', PLoS One, vol. 8, pp. Article numbere63346, http://dx.doi.org/10.1371/journal.pone.0063346
    Journal articles | 2012
    Associate Professor Carsten Schmitz-Peiffer
    Iyoda T; Zhang F; Sun L; Hao F; Schmitz-Peiffer C; Xu X; Cui M, 2012, 'Lysophosphatidic acid induces early growth response-1 (Egr-1) protein expression via protein kinase Cdelta-regulated extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) activation in vascular smooth muscle cells', The Journal of Biological Chemistry, vol. 287, pp. 22635 - 22642, http://dx.doi.org/10.1074/jbc.M111.335695
    Journal articles | 2012
    Associate Professor Carsten Schmitz-Peiffer
    Raddatz K; Frangioudakis G; Diakanastasis B; Liao BM; Leitges M; Schmitz-Peiffer C, 2012, 'Deletion of protein kinase Ce in mice has limited effects on liver metabolite levels but alters fasting ketogenesis and gluconeogenesis', Diabetologia, vol. 55, pp. 2789 - 2793, http://dx.doi.org/10.1007/s00125-012-2647-5
    Journal articles | 2012
    Associate Professor Carsten Schmitz-Peiffer
    Iyota T; Sun L; Hao F; Schmitz-Peiffer C; Xu X; Cui M-Z, 2012, 'Abstract 126: Lysophosphatidic Acid Induces Early Growth Response Protein 1 Expression via the Protein Kinase Cδ-Regulated ERK and JNK Activation in Vascular Smooth Muscle Cells', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 32, http://dx.doi.org/10.1161/atvb.32.suppl_1.a126
    Journal articles | 2012
    Associate Professor Carsten Schmitz-Peiffer
    Schmitz-Peiffer C; Raddatz K; Liao B-QM; Diakanastasis B, 2012, 'Proteomic analysis of livers from fat-fed PKC epsilon and PKC delta KO mice: insights into the modulation hepatic lipid metabolism as well as insulin action by PKC isoforms', DIABETOLOGIA, vol. 55, pp. S15 - S15, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000208826500022&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 2010
    Associate Professor Carsten Schmitz-Peiffer
    Frangioudakis G; Garrard J; Raddatz K; Nadler JL; Mitchell T; Schmitz-Peiffer C, 2010, 'Saturated and n-6 polyunsaturated-fat diets each induce ceramide accumulation in moue skeletal muscle: reversal and improvement of glucose tolerance by lipid metabolism inhibitors', Endocrinology, vol. 151, pp. 4187 - 4196, http://dx.doi.org/10.1210/en.2010-0250
    Journal articles | 2010
    Associate Professor Carsten Schmitz-Peiffer
    Schmitz-Peiffer C; Biden TJ, 2010, 'PKCδ blues for the β-cell', Diabetes, vol. 59, pp. 1 - 3, http://dx.doi.org/10.2337/db09-1439
    Journal articles | 2010
    Associate Professor Carsten Schmitz-Peiffer
    Schmitz-Peiffer C, 2010, 'Targeting ceramide synthesis to reverse insulin resistance', Diabetes, vol. 59, pp. 2351 - 2353, http://dx.doi.org/10.2337/db10-0912
    Journal articles | 2009
    Associate Professor Carsten Schmitz-Peiffer
    Frangioudakis G; Burchfield JG; Narasimhan S; Cooney GJ; Leitges M; Biden TJ; Schmitz-Peiffer C, 2009, 'Diverse roles for protein kinase C delta and protein kinase C epsilon in the generation of high-fat-diet-induced glucose intolerance in mice: regulation of lipogenesis by protein kinase C delta', Diabetologia, vol. 52, pp. 2616, http://dx.doi.org/10.1007/s00125-009-1543-0
    Journal articles | 2009
    Associate Professor Carsten Schmitz-Peiffer
    Cantley J; Burchfield JG; Pearson G; Schmitz-Peiffer C; Leitges M; Biden TJ, 2009, 'Deletion of PKC epsilon Selectively Enhances the Amplifying Pathways of Glucose-Stimulated Insulin Secretion via Increased Lipolysis in Mouse beta-Cells', Diabetes, vol. 58, pp. 1826 - 1834, http://dx.doi.org/10.2337/db09-0132
    Journal articles | 2008
    Associate Professor Carsten Schmitz-Peiffer
    Schmitz-Peiffer C; Biden TJ, 2008, 'Protein kinase C function in muscle, liver, and beta-cells and its therapeutic implications for type 2 diabetes', Diabetes, vol. 57, pp. 1774 - 1783, http://dx.doi.org/10.2337/db07-1769
    Journal articles | 2008
    Associate Professor Carsten Schmitz-Peiffer
    Biden TJ; Schmitz-Peiffer C; Burchfield JG; Gurisik E; Cantley J; Mitchell CJ; Carpenter L, 2008, 'The diverse roles of protein kinase C in pancreatic beta-cell function', Biochemical Society Transactions, vol. 36, pp. 916 - 919, http://dx.doi.org/10.1042/BST0360916
    Journal articles | 2007
    Associate Professor Carsten Schmitz-Peiffer
    Cazzolli R; Mitchell T; Burchfield JG; Pedersen D; Turner N; Biden TJ; Schmitz-Peiffer C, 2007, 'Dilinoleoyl-phosphatidic acid mediates reduced IRS-1 tyrosine phosphorylation in rat skeletal muscle cells and mouse muscle', Diabetologia, vol. 50, pp. 1732 - 1742, http://dx.doi.org/10.1007/s00125-007-0709-x
    Journal articles | 2007
    Associate Professor Carsten Schmitz-Peiffer
    Schmitz-Peiffer C; Laybutt DR; Burchfield JG; Gurisik E; Narasimhan S; Mitchell CJ; Pedersen D; Braun U; Cooney GJ; Leitges M; Biden TJ, 2007, 'Inhibition of PKC epsilon improves glucose-stimulated insulin secretion and reduces insulin clearance', Cell Metabolism, vol. 6, pp. 320 - 328, http://dx.doi.org/10.1016/j.cmet.2007.08.012
    Journal articles | 2006
    Associate Professor Carsten Schmitz-Peiffer
    Rolph MS; Young TR; Shum BOV; Gorgun CZ; Schmitz-Peiffer C; Ramshaw IA; Hotamisligil GS; Mackay CR, 2006, 'Regulation of dendritic cell function and T cell priming by the fatty acid-binding protein aP2', Journal of Immunology, vol. 177, pp. 7794 - 7801, http://dx.doi.org/10.4049/jimmunol.177.11.7794
    Journal articles | 2006
    Associate Professor Carsten Schmitz-Peiffer
    Taylor AJ; Ye J; Schmitz-Peiffer C, 2006, 'Inhibition of glycogen synthesis by increased lipid availability is associated with subcellular redistribution of glycogen synthase', Journal of Endocrinology, vol. 188, pp. 11 - 23, http://dx.doi.org/10.1677/joe.1.06381
    Journal articles | 2006
    Associate Professor Carsten Schmitz-Peiffer
    Ludowyke RI; Elgund Z; Kranenburg T; Stehn J; Schmitz-Peiffer C; Hughes WE; Biden TJ, 2006, 'Phosphorylation of non-muscle myosin heavy chain IIA on serine-1917 is mediated by protein kinase CâII and coincides with the onset of stimulated degranulation of RBL-2H3 mast cells', Journal of Immunology, vol. 177, pp. 1492 - 1499
    Journal articles | 2006
    Associate Professor Carsten Schmitz-Peiffer
    Thomas E; Zhe Y; Molero JC; Schmitz-Peiffer C; Ramm G; James DE; Whitehead J, 2006, 'The subcellular fractionation properties and function of insulin receptor substrate-1 (IRS-1) are independent of cytoskeletal integrity', International Journal of Biochemistry and Cell Biology, vol. 38, pp. 1686 - 1699, http://dx.doi.org/10.1016/j.biocel.2006.03.009
    Journal articles | 2005
    Associate Professor Carsten Schmitz-Peiffer
    Schmitz-Peiffer C, 2005, 'Targeting protein kinase C epsilon or theta as a therapeutic strategy for insulin resistance', Drug Discovery Today: Therapeutic Strategies, vol. 2, pp. 105 - 110, http://dx.doi.org/10.1016/j.ddstr.2005.04.002
    Journal articles | 2002
    Associate Professor Carsten Schmitz-Peiffer
    Cazzolli R; Craig DL; Biden TJ; Schmitz-Peiffer C, 2002, 'Inhibition of glycogen synthesis by fatty acid in C2C12 muscle cells is independent of PKC-alpha, -epsilon, and -theta', AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, vol. 282, pp. E1204 - E1213, http://dx.doi.org/10.1152/ajpendo.00487.2001
    Journal articles | 2002
    Associate Professor Carsten Schmitz-Peiffer
    Schmitz-Peiffer C, 2002, 'Protein kinase C and lipid-induced insulin resistance in skeletal muscle', Annals of the New York Academy of Sciences, vol. 967, pp. 146 - 157, http://dx.doi.org/10.1111/j.1749-6632.2002.tb04272.x
    Journal articles | 2001
    Associate Professor Carsten Schmitz-Peiffer
    Cazzolli R; Carpenter L; Biden TJ; Schmitz-Peiffer C, 2001, 'A Role for Protein Phosphatase 2A-Like Activity, but Not Atypical Protein Kinase Cζ, in the Inhibition of Protein Kinase B/Akt and Glycogen Synthesis by Palmitate', Diabetes, vol. 50, pp. 2210 - 2218, http://dx.doi.org/10.2337/diabetes.50.10.2210
    Journal articles | 2000
    Associate Professor Carsten Schmitz-Peiffer
    Schmitz-Peiffer C, 2000, 'Signalling aspects of insulin resistance in skeletal muscle: Mechanisms induced by lipid oversupply', Cellular Signalling, vol. 12, pp. 583 - 594, http://dx.doi.org/10.1016/S0898-6568(00)00110-8
    Journal articles | 2000
    Associate Professor Carsten Schmitz-Peiffer
    Bell KS; Schmitz-Peiffer C; Lim-Fraser M; Biden TJ; Cooney GJ; Kraegen EW, 2000, 'Acute reversal of lipid-induced muscle insulin resistance is associated with rapid alteration in PKC-θ localization', American Journal of Physiology - Endocrinology and Metabolism, vol. 279, http://dx.doi.org/10.1152/ajpendo.2000.279.5.e1196
    Journal articles | 2000
    Associate Professor Carsten Schmitz-Peiffer
    Bell KS; Schmitz-Peiffer C; Lim-Fraser M; Biden TJ; Cooney GJ; Kraegen EW, 2000, 'Acute reversal of lipid-induced muscle insulin resistance is associated with rapid alteration in PKC-theta localization', AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, vol. 279, pp. E1196 - E1201, http://dx.doi.org/10.1152/ajpendo.2000.279.5.E1196
    Journal articles | 1996
    Associate Professor Carsten Schmitz-Peiffer
    Schmitz-Peiffer C; Browne CL; Biden TJ, 1996, 'Characterization of two forms of protein kinase C α, with different substrate specificities, from skeletal muscle', Biochemical Journal, vol. 320, pp. 207 - 214, http://dx.doi.org/10.1042/bj3200207
    Journal articles | 1996
    Associate Professor Carsten Schmitz-Peiffer
    Schmitz-Peiffer C; Browne CL; Oakes ND; Watkinson A; Chisholm DJ; Kraegen EW; Biden TJ, 1996, 'P-101: Alterations in the expression and cellular localization of protein kinase C isozymes are associated with insulin resistance in skeletal muscle of the high-fat-fed rat', Experimental and Clinical Endocrinology and Diabetes, vol. 104, pp. 161 - 162, http://dx.doi.org/10.1055/s-0029-1211645
    Journal articles | 1993
    Associate Professor Carsten Schmitz-Peiffer
    Selbie LA; Schmitz-Peiffer C; Sheng Y; Biden TJ, 1993, 'Molecular cloning and characterization of PKC(t), an atypical isoform of protein kinase C derived from insulin-secreting cells', Journal of Biological Chemistry, vol. 268, pp. 24296 - 24302
    Journal articles | 1992
    Associate Professor Carsten Schmitz-Peiffer
    Schmitz-Peiffer C; Reeves ML; Denton RM, 1992, 'Characterization of the cyclic nucleotide phosphodiesterase isoenzymes present in rat epididymal fat cells', Cellular Signalling, vol. 4, pp. 37 - 49, http://dx.doi.org/10.1016/0898-6568(92)90006-T
    Journal articles | 1992
    Associate Professor Carsten Schmitz-Peiffer
    Denton RM; Tavare JM; Borthwick A; Dickens M; Diggle TA; Edgell NJ; Heesom KJ; Isaad T; Lynch DF; Moule SK; Schmitz-Peiffer C; Welsh GI, 1992, 'Insulin-activated protein kinases in fat and other cells', Biochemical Society Transactions, vol. 20, pp. 659 - 664, http://dx.doi.org/10.1042/bst0200659
    Journal articles | 1991
    Associate Professor Carsten Schmitz-Peiffer
    Diggle TA; Schmitz-Peiffer C; Borthwick AC; Welsh GI; Denton RM, 1991, 'Evidence that insulin activates casein kinase 2 in rat epididymal fat-cells and that this may result in the increased phosphorylation of an acid-soluble 22 kDa protein', Biochemical Journal, vol. 279, pp. 545 - 551, http://dx.doi.org/10.1042/bj2790545
    Journal articles | 1990
    Associate Professor Carsten Schmitz-Peiffer
    Murray KJ; England PJ; Lynham JA; Mills D; Schmitz-Peiffer C; Reeves ML, 1990, 'Use of a synthetic dodecapeptide (malantide) to measure the cyclic AMP-dependent protein kinase activity ratio in a variety of tissues', Biochemical Journal, vol. 267, pp. 703 - 708, http://dx.doi.org/10.1042/bj2670703
  • Conference Abstracts | 2015
    Associate Professor Carsten Schmitz-Peiffer
    O'Reilly L; Cantley J; Turner V; Brink R; Schmitz-Peiffer C; Biden TJ, 2015, 'Deletion of PKC epsilon in islet-associated macrophages improves beta cell function', in DIABETOLOGIA, SPRINGER, Stockholm, SWEDEN, Vol. 58, pp. S219 - S219, presented at 51st Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Stockholm, SWEDEN, 14 September 2015 - 18 September 2015, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000359820901131&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2010
    Associate Professor Carsten Schmitz-Peiffer
    Pedersen D; Schmitz-Peiffer C, 2010, 'The Role of Protein Kinase C epsilon in the Regulation of Insulin Receptor Trafficking and Insulin Action', in DIABETES, AMER DIABETES ASSOC, Orlando, FL, pp. A383 - A383, presented at 70th Annual Meeting of the American-Diabetes-Association, Orlando, FL, 25 June 2010 - 29 June 2010, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000278844602061&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2008
    Associate Professor Carsten Schmitz-Peiffer
    Cantley J; Pearson GL; Burchfield JG; Schmitz-Peiffer C; Biden TJ, 2008, 'Deletion of protein kinase C epsilon in mice enhances glucose stimulated insulin secretion following lipid exposure by up-regulation of the amplifying pathways of insulin secretion', in DIABETOLOGIA, SPRINGER, Rome, ITALY, Vol. 51, pp. S202 - S202, presented at 44th Annual Meeting of the European-Association-for-the-Study-of-Diabetes, Rome, ITALY, 07 September 2008 - 11 September 2008, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000258660200490&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2003
    Associate Professor Carsten Schmitz-Peiffer
    Burchfield J; Biden T; Schmitz-Peiffer C, 2003, 'Diacylglycerol kinase reverses unsaturated fatty acid-induced translocation of protein kinase C in skeletal muscle cells', in DIABETES, AMER DIABETES ASSOC, NEW ORLEANS, LOUISIANA, pp. A305 - A305, presented at 63rd Scientific Sessions of the American-Diabetes-Association, NEW ORLEANS, LOUISIANA, 13 June 2003 - 17 June 2003, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000183173801305&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2003
    Associate Professor Carsten Schmitz-Peiffer
    Taylor A; Biden T; Schmitz-Peiffer C, 2003, 'Unsaturated free fatty acid treatment lowers glycogen synthase protein in L6 skeletal muscle cells', in DIABETES, AMER DIABETES ASSOC, NEW ORLEANS, LOUISIANA, pp. A295 - A296, presented at 63rd Scientific Sessions of the American-Diabetes-Association, NEW ORLEANS, LOUISIANA, 13 June 2003 - 17 June 2003, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000183173801265&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 1999
    Associate Professor Carsten Schmitz-Peiffer
    Schmitz-Peiffer C; Craig DL; Biden TJ, 1999, 'Evidence for the involvement of ceramide in the inhibition of insulin action by palmitate in mouse C2C12 skeletal muscle cells', in DIABETES, AMER DIABETES ASSOC, Vol. 48, pp. A331 - A331, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000080215401423&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 1997
    Associate Professor Carsten Schmitz-Peiffer
    Laybutt DR; SchmitzPeiffer C; Saha A; Ruderman N; Chisholm D; Biden T; Kraegen E, 1997, 'Activation of protein kinase C epsilon may contribute to muscle insulin resistance induced by lipid accumulation during chronic glucose infusion in rats.', in DIABETES, AMER DIABETES ASSOC, pp. 923 - 923, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1997WX38000920&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 1993
    Associate Professor Carsten Schmitz-Peiffer
    BIDEN TJ; SCHMITZPEIFFER C; SHENG Y; SELBIE LA, 1993, 'ISOLATION AND CLONING OF A NOVEL PROTEIN-KINASE-C ISOFORM FROM RINM5F CELLS', in DIABETOLOGIA, SPRINGER VERLAG, Vol. 36, pp. A5 - A5, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1993LZ27400010&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 1993
    Associate Professor Carsten Schmitz-Peiffer
    SCHMITZPEIFFER C; BIDEN TJ, 1993, 'REGULATION OF PROTEIN-KINASE-C ALPHA-SUBSTRATE SPECIFICITY IN RED SKELETAL-MUSCLE', in DIABETOLOGIA, SPRINGER VERLAG, Vol. 36, pp. A44 - A44, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1993LZ27400166&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Awards

Garvan Institute High Impact Publication Prize 2019

Garvan Institute High Impact Publication Prize 2007

 

Grants

Carsten Schmitz-Peiffer has obtained over $3 million in peer-reviewed grant funding as CIA. He has been awarded 6 NHMRC project grants as CIA since 2003, and an NHMRC Development Grant as CIB (2007). He has also received funding from Diabetes Australia Research Trust (9 grants since 2002), Eli Lilly Endocrinology Research Grants (2 grants) and a recent Perpetual Impact Grant (2019-2020) as CIA.

 

NHMRC

2015-2019 NHMRC Project Grant $872,512

Action of PKC epsilon in Adipose Tissue Regulates Hepatic Glucose Production

CIA: C. Schmitz-Peiffer, CIB: T.J. Biden

 

2011-2013 NHMRC Project Grant $583,390

Targeting ceramide metabolism to improve insulin resistance

CIA: C. Schmitz-Peiffer, CIB: T. Mitchell

 

2009-2011 Project Grant $622,500

The regulation of insulin action in liver and skeletal muscle by Protein kinase C epsilon

CIA: C. Schmitz-Peiffer, CIB: T.J. Biden

 

2008-2010 Project Grant $483,750

Dilinoleoyl phosphatidic acid as a novel mediator of insulin resistance in muscle.

CIA: C. Schmitz-Peiffer, CIB: T. Mitchell

 

2006-2008 Project Grant $614,625

Investigation of the roles of Protein Kinase Cε in insulin secretion and insulin clearance.

CIA: C. Schmitz-Peiffer, CIB: T.J. Biden

 

2007 Development Grant $154,500

Therapeutic Strategies and Screening Methods for PKC epsilon antagonists in the treatment of Type 2 diabetes

CIA: T.J. Biden,  CIB: C. Schmitz-Peiffer

 

2003-2005 New Investigator Grant $450,000

The Role of Protein Kinase Cε in the Generation of Lipid-Induced Insulin Resistance in Skeletal Muscle

CIA: C. Schmitz-Peiffer

 

Other Grants

2019-2020       Perpetual Impact Grant $65,000

Identifying new dual action therapies for the treatment of type 2 diabetes

Chief Investigator: C. Schmitz-Peiffer

 

2019    Diabetes Australia Research Trust $60,000

Using Biosensors To Determine the Role of PKCε in Adipose Tissue

Chief Investigator: C. Schmitz-Peiffer

 

2018    Diabetes Australia Research Trust $60,000

Dual Deletion of PKCepsilon and CerS6 in Adipose Tissue to Protect Insulin Sensitivity

Chief Investigator: C. Schmitz-Peiffer

 

2016   Diabetes Australia Research Trust $60,000

Inhibitors of Protein Kinase C Epsilon (PKCe) for the Treatment of Type 2 Diabetes

Chief Investigators: R. Norton, C. Schmitz-Peiffer

 

2015    Diabetes Australia Research Trust $60,000

The role of protein kinase C in the regulation of lipid metabolism and glucose homeostasis

Chief Investigator: C. Schmitz-Peiffer

 

2012    Diabetes Australia Research Trust $39,000

The role of branched chain amino acid degradation in the improvement of glucose homeostasis caused by protein kinase C epsilon deletion

Chief Investigator: C. Schmitz-Peiffer

 

2011    Diabetes Australia Research Trust $60,000

Regulation of Insulin Receptor Function by PKC epsilon

Chief Investigator: C. Schmitz-Peiffe

 

2008    Eli Lilly Endocrinology Research Grant, $40,000

Project: Inhibition of lysophosphatidic acid acyl transferase (LPAAT) as a treatment for insulin resistance and Type 2 diabetes

Chief Investigator: C. Schmitz-Peiffer

 

2007    Rebecca L. Cooper Medical Research Foundation

Equipment Grant: $20,000

Chief Investigator: C. Schmitz-Peiffer

 

2006    Diabetes Australia Research Trust, $30,000

Project: Investigation of the role of Protein Kinase Cε in insulin clearance.

Chief Investigator: C. Schmitz-Peiffer

 

2005    Eli Lilly Endocrinology Research Grant, $30,000

Project: The Role Of The Protein Kinase mTOR In Lipid-Induced Insulin Resistance In Skeletal Muscle Cells

Chief Investigator: C. Schmitz-Peiffer

 

2004    Diabetes Australia Research Trust, $40,000

Project: Inhibitory Regulation of Glycogen Synthase by Unsaturated Fatty Acid

Chief Investigator: C. Schmitz-Peiffer

 

2002    Diabetes Australia Research Trust, $40,000

Project: Unsaturated Fatty Acid, PKC And n-3 Fatty Acid Effects On Insulin Signalling.

Chief Investigator: C. Schmitz-Peiffer

 

Support for Translational Projects

2015 European Lead Factory Public Target Programme ELFSC13_04

Inhibitors Of the interaction of PKCe and RACK2 As Agents For The Treatment Of T2D

ELF to perform HTS AlphaScreen for inhibitors of PKCε-RACK2 interaction, confirm hits, deselect non-specific hits, dose response curve, selectivity profile, orthogonal assays.

Chief Investigators: Dr Graeme Wilkinson (The Research Network, UK); C. Schmitz-Peiffer

 

2014 AstraZeneca / Academic Drug Discovery Consortium

Free access to ready-to-screen 250,000 compound library worth $130,000

Inhibitors of protein kinase C epsilon as agents for the treatment of type 2 diabetes

Chief Investigators: C. Schmitz-Peiffer, J. Baell, K. Laclovic, T.J. Biden

 

2012  Regeneus Pty Ltd, $30,000

Mesenchymal stem cells as a therapy for Type 2 diabetes

Chief Investigator: C. Schmitz-Peiffer

 

2010    Garvan Institute Business Development funding $97,000

Use of peptide inhibitors of PKCε to treat glucose intolerance

Chief Investigators: T.J. Biden, C. Schmitz-Peiffer

 

2006    Devgen NV, $20,000

Treatment of pancreatic β-cell dysfunction and insulin resistance by inhibition of PKCε

Chief Investigators: C. Schmitz-Peiffer, T.J. Biden

Media