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Dr Celine Santiago

Dr Celine Santiago

Conjoint Associate Lecturer

Doctor of Philosophy (Medicine), 2021, Victor Chang Cardiac Research Institute & University of New South Wales. 

Bachelor of Biomedical Science (Hons I), 2014, School of Biomedical Sciences, The University of Queensland. 

Medicine & Health
School of Clinical Medicine

Dr. Celine Santiago is a post-doctoral researcher in the Sister Bernice Research Program for Inherited Heart Diseases at the Victor Chang Cardiac Research Institute in Sydney, and a Conjoint Associate Lecturer at the School of Clinical Medicine (St. Vincent's Clinical Campus), University of New South Wales. She completed an undergraduate degree in Biomedical Science at the University of Queensland in 2014 and graduated with Honours (Class I), before moving to Sydney in 2015. Dr. Santiago undertook higher degree research with Professor Diane Fatkin at the Victor Chang Cardiac Research Institute, investigating the role of gene-environment interactions in the common heart muscle disorder dilated cardiomyopathy using a unique zebrafish model from 2016-2020, and graduated with a Doctor of Philosophy in Medicine in 2021. 

Dr. Santiago plays an active role in improving equity, diversity and inclusion for all STEM professionals in the cardiovascular research community both at the national and international level, and she is a strong advocate for wellness and mental health in academia, particularly for early career researchers. 
Phone
+61-2-9295 8624
E-mail
c.santiago@victorchang.edu.au
Location
Victor Chang Cardiac Research Institute, 405 Liverpool St Darlinghurst NSW 2010
  • Journal articles | 2023
    Huttner IG; Santiago CF; Jacoby A; Cheng D; Trivedi G; Cull S; Cvetkovska J; Chand R; Berger J; Currie PD; Smith KA; Fatkin D, 2023, 'Loss of Sec-1 Family Domain-Containing 1 (scfd1) Causes Severe Cardiac Defects and Endoplasmic Reticulum Stress in Zebrafish', Journal of Cardiovascular Development and Disease, 10, http://dx.doi.org/10.3390/jcdd10100408
    Journal articles | 2022
    Santiago C; Huttner IG; Wang LW; Chand R; Cvetkovska J; Zhao G; Hesselson D; Hinits Y; O'Brien A; Feneley M; Smith K; Linke W; Gautel M; Fatkin D, 2022, 'Position-dependent effects of titin truncation on the heart', JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 173, pp. S20 - S21, http://dx.doi.org/10.1016/j.yjmcc.2022.08.042
    Journal articles | 2022
    Santiago CF; Huttner IG; Fatkin D, 2022, 'Titin-related Cardiomyopathy: Is it a Distinct Disease?', Current Cardiology Reports, 24, pp. 1069 - 1075, http://dx.doi.org/10.1007/s11886-022-01726-0
    Journal articles | 2021
    Santiago C; Huttner I; Chand R; Humphreys D; Young P; Ward A; Fatkin D, 2021, 'TTNtv Carriers do not Have Increased Susceptibility to Chemotherapy-Induced Cardiomyopathy', Heart, Lung and Circulation, 30, pp. S97 - S97, http://dx.doi.org/10.1016/j.hlc.2021.06.018
    Journal articles | 2021
    Santiago CF; Huttner IG; Fatkin D, 2021, 'Mechanisms of TTNtv-related dilated cardiomyopathy: Insights from zebrafish models', Journal of Cardiovascular Development and Disease, 8, pp. 1 - 18, http://dx.doi.org/10.3390/jcdd8020010
    Journal articles | 2020
    Santiago C; Chand R; Humphreys D; Young P; Ward A; Huttner I; Fatkin D, 2020, '002 Titin Truncation Provides a Sensitised Template for Cardio-Depressant Effects of Alcohol', Heart, Lung and Circulation, 29, pp. S37 - S38, http://dx.doi.org/10.1016/j.hlc.2020.09.009
    Journal articles | 2018
    Huttner IG; Wang LW; Santiago CF; Horvat C; Johnson R; Cheng D; von Frieling-Salewsky M; Hillcoat K; Bemand TJ; Trivedi G; Braet F; Hesselson D; Alford K; Hayward CS; Seidman JG; Seidman CE; Feneley MP; Linke WA; Fatkin D, 2018, 'A-Band Titin Truncation in Zebrafish Causes Dilated Cardiomyopathy and Hemodynamic Stress Intolerance', Circulation. Genomic and precision medicine, 11, pp. e002135, http://dx.doi.org/10.1161/CIRCGEN.118.002135
    Journal articles | 2018
    Wang L; Huttner I; Santiago C; Hesselson D; Smith K; Linke W; Feneley M; Fatkin D, 2018, 'Titin Truncation Position Determines Propensity for Dilated Cardiomyopathy, Impaired Ventricular Relaxation and Passive Stiffness in Zebrafish', Heart, Lung and Circulation, 27, pp. S42 - S43, http://dx.doi.org/10.1016/j.hlc.2018.06.004
    Journal articles | 2018
    Zhang H; Dvornikov AV; Huttner IG; Ma X; Santiago CF; Fatkin D; Xu X, 2018, 'A Langendorff-like system to quantify cardiac pump function in adult zebrafish', DMM Disease Models and Mechanisms, 11, http://dx.doi.org/10.1242/dmm.034819
    Journal articles | 2017
    Fatkin D; Santiago CF; Huttner IG; Lubitz SA; Ellinor PT, 2017, 'Genetics of Atrial Fibrillation: State of the Art in 2017', Heart Lung and Circulation, 26, pp. 894 - 901, http://dx.doi.org/10.1016/j.hlc.2017.04.008
    Journal articles | 2017
    Huttner I; Wang L; Santiago C; Horvat C; Johnson R; Cheng D; Braet F; Hesselson D; Feneley M; Fatkin D, 2017, 'A Zebrafish Model of a Human Titin-truncating Mutation Exhibits Spontaneous, Age-dependent and Load-exacerbated Dilated Cardiomyopathy', Heart, Lung and Circulation, 26, pp. S43 - S43, http://dx.doi.org/10.1016/j.hlc.2017.06.002
    Journal articles | 2017
    Wang LW; Huttner IG; Santiago CF; Kesteven SH; Yu ZY; Feneley MP; Fatkin D; Martin I, 2017, 'Standardized echocardiographic assessment of cardiac function in normal adult zebrafish and heart disease models', DMM Disease Models and Mechanisms, 10, pp. 63 - 76, http://dx.doi.org/10.1242/dmm.026989
    Journal articles | 2016
    Christensen AH; Chatelain FC; Huttner IG; Olesen MS; Soka M; Feliciangeli S; Horvat C; Santiago CF; Vandenberg JI; Schmitt N; Olesen SP; Lesage F; Fatkin D; Martin I, 2016, 'The two-pore domain potassium channel, TWIK-1, has a role in the regulation of heart rate and atrial size', Journal of Molecular and Cellular Cardiology, 97, pp. 24 - 35, http://dx.doi.org/10.1016/j.yjmcc.2016.04.006
    Journal articles | 2016
    Wang L; Huttner I; Santiago C; Yu Z; Kesteven S; Feneley M; Fatkin D, 2016, 'Development and Validation of a Novel Technique for High Frequency Echocardiography in Zebrafish Models of Health and Disease Provide Key Insights into Cardiac Physiology and Applications for Studying Heart Failure', Heart, Lung and Circulation, 25, pp. S106 - S106, http://dx.doi.org/10.1016/j.hlc.2016.06.251
  • Conference Abstracts | 2019
    Santiago C; Huttner I; Fatkin D, 2019, 'Chronic alcohol exposure exacerbates cardiac dysfunction in TTNtv-related dilated cardiomyopathy', in JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, ELSEVIER SCI LTD, PEOPLES R CHINA, Beijing, Vol. 140, pp. 23 - 23, presented at 23rd World Congress of the International-Society-for-Heart-Research (ISHR), PEOPLES R CHINA, Beijing, 03 June 2019 - 06 June 2019, http://dx.doi.org/10.1016/j.yjmcc.2019.11.053
    Reports | 2016
    Wang LW; Huttner IG; Santiago CF; Fatkin D; Martin I, 2016, Bradycardia in Zebrafish Heart Failure: A True Physiological Response or Anesthetic-Induced Red Herring?, http://dx.doi.org/10.1089/zeb.2016.1367
    Preprints |
    Fatkin D; Huttner IG; Santiago CF; Jacoby A; Cheng D; Trivedi G; Cull S; Cvetkovska J; Chand R; Berger J; Currie PD; Smith KA, Loss of Sec-1 Family Domain-Containing 1 (Scfd1) Causes Severe Cardiac Defects and Endoplasmic Reticulum Stress in Zebrafish, , http://dx.doi.org/10.2139/ssrn.4329887

Dr. Santiago has a continued interest in investigating gene-environment interactions and genetic causes of dilated cardiomyopathy (DCM). Using genome-engineering to replicate genetic variants found in human DCM patients in zebrafish, Dr. Santiago can identify potential new genetic causes of DCM and study how these variants affect heart structure and function overall, and at the molecular level, from youth to adulthood - something that is highly challenging to do in human cohort and rodent studies. As part of her research, Dr. Santiago develops novel miniaturised tools to increase the utility of zebrafish as a model for cardiovascular research, such as high-frequency underwater echocardiography, non-invasive electrocardiography, cardio-metabolomics and transcriptomics.