Dr Celine Santiago
Conjoint Associate Lecturer

Dr Celine Santiago

Doctor of Philosophy (Medicine), 2021, Victor Chang Cardiac Research Institute & University of New South Wales. 

Bachelor of Biomedical Science (Hons I), 2014, School of Biomedical Sciences, The University of Queensland. 

Medicine & Health
School of Clinical Medicine

Dr. Celine Santiago is a post-doctoral researcher in the Sister Bernice Research Program for Inherited Heart Diseases at the Victor Chang Cardiac Research Institute in Sydney, and a Conjoint Associate Lecturer at the School of Clinical Medicine (St. Vincent's Clinical Campus), University of New South Wales. She completed an undergraduate degree in Biomedical Science at the University of Queensland in 2014 and graduated with Honours (Class I), before moving to Sydney in 2015. Dr. Santiago undertook higher degree research with Professor Diane Fatkin at the Victor Chang Cardiac Research Institute, investigating the role of gene-environment interactions in the common heart muscle disorder dilated cardiomyopathy using a unique zebrafish model from 2016-2020, and graduated with a Doctor of Philosophy in Medicine in 2021. 

Dr. Santiago plays an active role in improving equity, diversity and inclusion for all STEM professionals in the cardiovascular research community both at the national and international level, and she is a strong advocate for wellness and mental health in academia, particularly for early career researchers. 

Phone
+61-2-9295 8624
Location
Victor Chang Cardiac Research Institute, 405 Liverpool St Darlinghurst NSW 2010
  • Journal articles | 2018
    Zhang H; Dvornikov AV; Huttner IG; Ma X; Santiago CF; Fatkin D; Xu X, 2018, 'A Langendorff-like system to quantify cardiac pump function in adult zebrafish', DMM Disease Models and Mechanisms, vol. 11, http://dx.doi.org/10.1242/dmm.034819

Dr. Santiago has a continued interest in investigating gene-environment interactions and genetic causes of dilated cardiomyopathy (DCM). Using genome-engineering to replicate genetic variants found in human DCM patients in zebrafish, Dr. Santiago can identify potential new genetic causes of DCM and study how these variants affect heart structure and function overall, and at the molecular level, from youth to adulthood - something that is highly challenging to do in human cohort and rodent studies. As part of her research, Dr. Santiago develops novel miniaturised tools to increase the utility of zebrafish as a model for cardiovascular research, such as high-frequency underwater echocardiography, non-invasive electrocardiography, cardio-metabolomics and transcriptomics.