Dr Chai Ng

Dr. Chai-Ann Ng is transforming the landscape of cardiac genetic research through his pioneering work in precision medicine for cardiac channelopathies. He has developed the first globally validated functional assays for ion channel variants, setting new standards in the field. These assays provide reliable, high-throughput data to reclassify Variants of Uncertain Significance (VUS), enabling accurate genetic diagnoses and actionable clinical decisions. His research addresses critical challenges in managing cardiac channelopathies, such as long QT syndrome, a heart rhythm disorder that can cause sudden cardiac death, by distinguishing pathogenic variants from benign ones with unprecedented precision. His functional data not only improves diagnostic accuracy but also facilitates risk stratification, guiding clinicians in identifying high-risk individuals who may require interventions like implantable cardioverter-defibrillators. His work also drives personalised treatment by supporting targeted pharmacotherapy based on variant-specific functional defects. Collaborating with global laboratories and clinicians, Dr. Ng has implemented this approach to reclassify VUS for hundreds of patients, significantly improving outcomes. His research is a cornerstone in the shift towards precision medicine, offering families clear answers, enabling cascade testing, and reducing the risk of sudden cardiac death. Dr. Ng’s contributions exemplify innovation with real-world impact, reshaping the clinical management of genetic cardiac disorders.