Dr David Herrmann

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Phone

+61293555851

E-mail

d.herrmann@garvan.org.au

Location

Garvan Institute of Medical Research / The Kinghorn Cancer Centre Darlinghurst

Journal articles | 2024

Pereira BA; Ritchie S; Chambers CR; Gordon KA; Magenau A; Murphy KJ; Nobis M; Tyma VM; Liew YF; Lucas MC; Naeini MM; Barkauskas DS; Chacon-Fajardo D; Howell AE; Parker AL; Warren SC; Reed DA; Lee V; Metcalf XL; Lee YK; O'Regan LP; Zhu J; Trpceski M; Fontaine ARM; Stoehr J; Rouet R; Lin X; Chitty JL; Porazinski S; Wu SZ; Filipe EC; Cadell AL; Holliday H; Yang J; Papanicolaou M; Lyons RJ; Zaratzian A; Tayao M; Da Silva A; Vennin C; Yin J; Dew AB; McMillan PJ; Goldstein LD; Deveson IW; Croucher DR; Samuel MS; Sim HW; Batten M; Chantrill L; Grimmond SM; Gill AJ; Samra J; Jeffry Evans TR; Sasaki T; Phan TG; Swarbrick A; Sansom OJ; Morton JP; Pajic M; Parker BL; Herrmann D; Cox TR; Timpson P, 2024, 'Temporally resolved proteomics identifies nidogen-2 as a cotarget in pancreatic cancer that modulates fibrosis and therapy response', Science Advances, 10, http://dx.doi.org/10.1126/sciadv.adl1197

Journal articles | 2024

Sugiyama Y; Reed DA; Herrmann D; Lovicu FJ; Robinson ML; Timpson P; Masai I, 2024, 'Fibroblast growth factor-induced lens fiber cell elongation is driven by the stepwise activity of Rho and Rac', Development (Cambridge), 151, pp. 1 - 9, http://dx.doi.org/10.1242/dev.202123

Journal articles | 2024

Tyma V; Liew Y-F; Tran A; Howell A; Ritchie S; Pancreatic Cancer Matrix Atlas AA; Genome Initiative AP; Cox T; Pajic M; Herrmann D; Pereira B; Timpson P; Gordon K, 2024, 'Abstract A067: Identifying and targeting FOLFIRINOX resistance mechanisms to improve outcomes in pancreatic cancer', Cancer Research, 84, pp. A067 - A067, http://dx.doi.org/10.1158/1538-7445.pancreatic24-a067

Journal articles | 2023

Burns C; Murphy K; Cock T-A; Devlin M; Herrmann D; Timpson P, 2023, 'The effect of adding a selective FAK inhibitor AMP945 to FOLFIRINOX in a model of pancreatic cancer.', Journal of Clinical Oncology, 41, pp. e15128 - e15128, http://dx.doi.org/10.1200/jco.2023.41.16_suppl.e15128

Journal articles | 2023

Chitty JL; Yam M; Perryman L; Parker AL; Skhinas JN; Setargew YFI; Mok ETY; Tran E; Grant RD; Latham SL; Pereira BA; Ritchie SC; Murphy KJ; Trpceski M; Findlay AD; Melenec P; Filipe EC; Nadalini A; Velayuthar S; Major G; Wyllie K; Papanicolaou M; Ratnaseelan S; Phillips PA; Sharbeen G; Youkhana J; Russo A; Blackwell A; Hastings JF; Lucas MC; Chambers CR; Reed DA; Stoehr J; Vennin C; Pidsley R; Zaratzian A; Da Silva AM; Tayao M; Charlton B; Herrmann D; Nobis M; Clark SJ; Biankin AV; Johns AL; Croucher DR; Nagrial A; Gill AJ; Grimmond SM; Chantrill LA; Chou A; Dwarte T; Metcalf XL; Jeong G; Kenyon L; Waddell N; Pearson JV; Patch AM; Nones K; Newell F; Mukhopadhyay P; Addala V; Kazakoff S; Holmes O; Leonard C; Wood S; Hofmann O; Samra JS; Pavlakis N; Arena J; High HA; Asghari R; Merrett ND; Das A; Cosman PH; Ismail K; Stoita A; Williams D; Spigellman A; McLeo D; Kirk J; Kench JG; Grimison P; Sandroussi C; Goodwin A; Mead RS; Tucker K; Andrews L; Texler M; Forrest C; Ballal M; Fletcher D; Beilin M; Feeney K; Epari K; Mukhedkar S; Zeps N; Nguyen NQ; Ruszkiewicz AR; Worthley C; Chen J, 2023, 'A first-in-class pan-lysyl oxidase inhibitor impairs stromal remodeling and enhances gemcitabine response and survival in pancreatic cancer', Nature Cancer, 4, pp. 1326 - 1344, http://dx.doi.org/10.1038/s43018-023-00614-y

Journal articles | 2023

Conway JRW; Warren SC; Lee YK; McCulloch AT; Magenau A; Lee V; Metcalf XL; Stoehr J; Haigh K; Abdulkhalek L; Guaman CS; Reed DA; Murphy KJ; Pereira BA; Mélénec P; Chambers C; Latham SL; Lenthall H; Deenick EK; Ma Y; Phan T; Lim E; Joshua AM; Walters S; Grey ST; Shi YC; Zhang L; Herzog H; Croucher DR; Philp A; Scheele CLGJ; Herrmann D; Sansom OJ; Morton JP; Papa A; Haigh JJ; Nobis M; Timpson P, 2023, 'Monitoring AKT activity and targeting in live tissue and disease contexts using a real-time Akt-FRET biosensor mouse', Science Advances, 9, http://dx.doi.org/10.1126/sciadv.adf9063

Journal articles | 2023

Dreyer SB; Rae S; Bisset K; Upstill-Goddard R; Gemenetzis G; Johns AL; Dickson EJ; Mittal A; Gill AJ; Duthie F; Pea A; Lawlor RT; Scarpa A; Salvia R; Pulvirenti A; Zerbi A; Marchesi F; McKay CJ; Biankin AV; Samra JS; Chang DK; Jamieson NB, 2023, 'The Impact of Molecular Subtyping on Pathological Staging of Pancreatic Cancer', Annals of Surgery, 277, pp. E396 - E405, http://dx.doi.org/10.1097/SLA.0000000000005050

Journal articles | 2023

Sugiyama Y; Reed DA; Herrmann D; Lovicu FJ; Robinson ML; Timpson P; Masai I, 2023, 'Fibroblast Growth Factor-induced lens fiber cell elongation is driven by the stepwise activity of Rho and Rac.', bioRxiv, http://dx.doi.org/10.1101/2023.12.03.569812

Journal articles | 2023

Uceda-Castro R; Margarido AS; Song JY; de Gooijer MC; Messal HA; Chambers CR; Nobis M; Çitirikkaya CH; Hahn K; Seinstra D; Herrmann D; Timpson P; Wesseling P; van Tellingen O; Vennin C; van Rheenen J, 2023, 'BCRP drives intrinsic chemoresistance in chemotherapy-naïve breast cancer brain metastasis', Science Advances, 9, http://dx.doi.org/10.1126/sciadv.abp9530

Journal articles | 2022

Dreyer SB; Upstill-Goddard R; Legrini A; Biankin AV; Allison S; Beraldi D; Cameron E; Chang DK; Cooke SL; Cunningham R; Grimwood P; Kelly S; Marshall J; McDade B; Musgrove EA; Ramsay D; Evers L; Rebus S; Rahib L; Serrels B; Jamieson NB; McKay CJ; Westwood P; Williams N; Duthie F; Shen W; Pea A; Johns AL; Gill AJ; Chantrill LA; Timpson P; Chou A; Pajic M; Dwarte T; Herrmann D; Vennin C; Cox TR; Pereira B; Ritchiee S; Reed DA; Chambers CR; Metcalf X; Nobis M; Jeong G; Kenyon L; Lyons RJ; Waddell N; Pearson JV; Patch AM; Nones K; Newell F; Mukhopadhyay P; Addala V; Kazakoff S; Holmes O; Leonard C; Wood S; Grimmond SM; Hofmann O; Samra JS; Pavlakis N; Arena J; High HA; Asghari R; Merrett ND; Das A; Cosman PH; Ismail K; Stoita A; Williams D; Spigellman A; McLeod D; Kirk J; Kench JG; Grimison P; Sandroussi C; Goodwin A; Mead RS; Tucker K; Andrews L; Texler M; Forrest C; Ballal M; Fletcher D; Beilin M; Feeney K; Epari K; Mukhedkar S; Zeps N; Nguyen NQ; Ruszkiewicz AR; Worthley C; Chen J; Brooke-Smith ME; Papangelis V; Clouston AD; Barbour AP; O'Rourke TJ; Fawcett JW, 2022, 'Genomic and Molecular Analyses Identify Molecular Subtypes of Pancreatic Cancer Recurrence', Gastroenterology, 162, pp. 320 - 324.e4, http://dx.doi.org/10.1053/j.gastro.2021.09.022

Journal articles | 2022

Meagher NS; Gorringe KL; Wakefield M; Bolithon A; Pang CNI; Chiu DS; Anglesio MS; Mallitt KA; Doherty JA; Harris HR; Schildkraut JM; Berchuck A; Cushing-Haugen KL; Chezar K; Chou A; Tan A; Alsop J; Barlow E; Beckmann MW; Boros J; Bowtell DDL; Brand AH; Brenton JD; Campbell I; Cheasley D; Cohen J; Cybulski C; Elishaev E; Erber R; Farrell R; Fischer A; Fu Z; Gilks B; Gill AJ; Gourley C; Grube M; Harnett PR; Hartmann A; Hettiaratchi A; Høgdall CK; Huzarski T; Jakubowska A; Jimenez-Linan M; Kennedy CJ; Kim BG; Kim JW; Kim JH; Klett K; Koziak JM; Lai T; Laslavic A; Lester J; Leung Y; Li N; Liauw W; Lim BWX; Linder A; Lubinski J; Mahale S; Mateoiu C; McInerny S; Menkiszak J; Minoo P; Mittelstadt S; Morris D; Orsulic S; Park SY; Pearce CL; Pearson JV; Pike MC; Quinn CM; Mohan GR; Rao J; Riggan MJ; Ruebner M; Salfinger S; Scott CL; Shah M; Steed H; Stewart CJR; Subramanian D; Sung S; Tang K; Timpson P; Ward RL; Wiedenhoefer R; Thorne H; Cohen PA; Crowe P; Fasching PA; Gronwald J; Hawkins NJ; Høgdall E; Huntsman DG; James PA; Karlan BY; Kelemen LE; Kommoss S; Konecny GE; Modugno F, 2022, 'Gene-Expression Profiling of Mucinous Ovarian Tumors and Comparison with Upper and Lower Gastrointestinal Tumors Identifies Markers Associated with Adverse Outcomes', Clinical Cancer Research, 28, pp. 5383 - 5395, http://dx.doi.org/10.1158/1078-0432.CCR-22-1206

Journal articles | 2022

Murphy KJ; Reed DA; Chambers CR; Zhu J; Magenau A; Pereira BA; Timpson P; Herrmann D, 2022, 'Cell-derived Matrix Assays to Assess Extracellular Matrix Architecture and Track Cell Movement', Bio-protocol, 12, http://dx.doi.org/10.21769/BioProtoc.4570

Journal articles | 2022

Murphy KJ; Zhu J; Trpceski M; Pereira BA; Timpson P; Herrmann D, 2022, 'Focal adhesion kinase priming in pancreatic cancer, altering biomechanics to improve chemotherapy', Biochemical Society Transactions, 50, pp. 1129 - 1141, http://dx.doi.org/10.1042/BST20220162

Journal articles | 2022

Papanicolaou M; Parker AL; Yam M; Filipe EC; Wu SZ; Chitty JL; Wyllie K; Tran E; Mok E; Nadalini A; Skhinas JN; Lucas MC; Herrmann D; Nobis M; Pereira BA; Law AMK; Castillo L; Murphy KJ; Zaratzian A; Hastings JF; Croucher DR; Lim E; Oliver BG; Mora FV; Parker BL; Gallego-Ortega D; Swarbrick A; O’Toole S; Timpson P; Cox TR, 2022, 'Temporal profiling of the breast tumour microenvironment reveals collagen XII as a driver of metastasis', Nature Communications, 13, http://dx.doi.org/10.1038/s41467-022-32255-7

Journal articles | 2022

Scheele CLGJ; Herrmann D; Yamashita E; Lo Celso C; Jenne CN; Oktay MH; Entenberg D; Friedl P; Weigert R; Meijboom FLB; Ishii M; Timpson P; van Rheenen J, 2022, 'Multiphoton intravital microscopy of rodents', Nature Reviews Methods Primers, 2, http://dx.doi.org/10.1038/s43586-022-00168-w

Journal articles | 2021

Floerchinger A; Murphy KJ; Latham SL; Warren SC; McCulloch AT; Lee YK; Stoehr J; Mélénec P; Guaman CS; Metcalf XL; Lee V; Zaratzian A; Da Silva A; Tayao M; Rolo S; Phimmachanh M; Sultani G; McDonald L; Mason SM; Ferrari N; Ooms LM; Johnsson AKE; Spence HJ; Olson MF; Machesky LM; Sansom OJ; Morton JP; Mitchell CA; Samuel MS; Croucher DR; Welch HCE; Blyth K; Caldon CE; Herrmann D; Anderson KI; Timpson P; Nobis M, 2021, 'Optimizing metastatic-cascade-dependent Rac1 targeting in breast cancer: Guidance using optical window intravital FRET imaging', Cell Reports, 36, http://dx.doi.org/10.1016/j.celrep.2021.109689

Journal articles | 2021

Lakis V; Lawlor RT; Newell F; Patch AM; Mafficini A; Sadanandam A; Koufariotis LT; Johnston RL; Leonard C; Wood S; Rusev B; Corbo V; Luchini C; Cingarlini S; Landoni L; Salvia R; Milella M; Chang D; Bailey P; Jamieson NB; Duthie F; Gingras MC; Muzny DM; Wheeler DA; Gibbs RA; Milione M; Chantrill LA; Timpson P; Chou A; Pajic M; Murphy A; Dwarte T; Hermann D; Vennin C; Cox TR; Pereira B; Ritchie S; Reed DA; Chambers CR; Metcalf X; Nobis M; Mukhopadhyay P; Addala V; Kazakoff S; Holmes O; Xu Q; Hofmann O; Samra JS; Pavlakis N; Arena J; High HA; Asghari R; Merrett ND; Pavey D; Das A; Cosman PH; Ismail K; O’Connnor C; Stoita A; Williams D; Spigellman A; Lam VW; McLeod D; Kirk J; Kench JG; Grimison P; Sandroussi C; Goodwin A; Mead RS; Tucker K; Andrews L; Texler M; Forest C; Ballal M; Fletcher DR; Zeps N; Nguyen NQ; Ruszkiewicz AR; Worthley C; Chen J; Brooke-Smith ME; Papangelis V; Clouston AD; Barbour AP; O’Rourke TJ; Fawcett JW; Slater K; Hatzifotis M; Hodgkinson P; Nikfarjam M; Eshleman JR; Hruban RH; Wolfgang CL; Dixon J; Scardoni M; Bassi C; Grimaldi S; Cantù C; Bonizzato G; Bersani S; Biankin A; Johns A; Herrmann D, 2021, 'DNA methylation patterns identify subgroups of pancreatic neuroendocrine tumors with clinical association', Communications Biology, 4, pp. 155, http://dx.doi.org/10.1038/s42003-020-01469-0

Journal articles | 2021

Liu D; Sharbeen G; Phillips P; Johns AL; Gill AJ; Chantrill LA; Timpson P; Chou A; Pajic M; Dwarte T; Herrmann D; Vennin C; Cox TR; Pereira B; Ritchie S; Reed DA; Chambers CR; Metcalf X; Nobis M; Waddell N; Pearson JV; Patch AM; Nones K; Newell F; Mukhopadhyay P; Addala V; Kazakoff S; Holmes O; Leonard C; Wood S; Grimmond SM; Hofmann O; Samra JS; Pavlakis N; Arena J; High HA; Asghari R; Merrett ND; Das A; Cosman PH; Ismail K; Stoita A; Williams D; Spigellman A; Lam VW; McLeod D; Kirk J; Kench JG; Grimison P; Sandroussi C; Goodwin A; Mead RS; Tucker K; Andrews L; Texler M; Forrest C; Ballal M; Fletcher D; Beilin M; Feeney K; Epari K; Mukhedkar S; Zeps N; Nguyen NQ; Ruszkiewicz AR; Worthley C; Chen J; Brooke-Smith ME; Papangelis V; Clouston AD; Barbour AP; O’Rourke TJ; Fawcett JW; Slater K; Hatzifotis M; Hodgkinson P; Nikfarjam M; Eshleman JR; Hruban RH; Wolfgang CL; Scarpa A; Lawlor RT; Corbo V; Bassi C; Biankin AV; Jamieson NB; Chang DK; Dreyer SB; Ford CE, 2021, 'ROR1 and ROR2 expression in pancreatic cancer', BMC Cancer, 21, http://dx.doi.org/10.1186/s12885-021-08952-9

Journal articles | 2021

Murphy KJ; Chambers CR; Herrmann D; Timpson P; Pereira BA, 2021, 'Dynamic stromal alterations influence tumor-stroma crosstalk to promote pancreatic cancer and treatment resistance', Cancers, 13, http://dx.doi.org/10.3390/cancers13143481

Journal articles | 2021

Murphy KJ; Reed DA; Trpceski M; Herrmann D; Timpson P, 2021, 'Quantifying and visualising the nuances of cellular dynamics in vivo using intravital imaging', Current Opinion in Cell Biology, 72, pp. 41 - 53, http://dx.doi.org/10.1016/j.ceb.2021.04.007

Journal articles | 2021

Murphy KJ; Reed DA; Vennin C; Conway JRW; Nobis M; Yin JX; Chambers CR; Pereira BA; Lee V; Filipe EC; Trpceski M; Ritchie S; Lucas MC; Warren SC; Skhinas JN; Magenau A; Metcalf XL; Stoehr J; Major G; Parkin A; Bidanel R; Lyons RJ; Zaratzian A; Tayao M; Da Silva A; Abdulkhalek L; Gill AJ; Johns AL; Biankin AV; Samra J; Grimmond SM; Chou A; Goetz JG; Samuel MS; Lyons JG; Burgess A; Caldon CE; Horvath LG; Daly RJ; Gadegaard N; Wang Y; Sansom OJ; Morton JP; Cox TR; Pajic M; Herrmann D; Timpson P, 2021, 'Intravital imaging technology guides FAK-mediated priming in pancreatic cancer precision medicine according to Merlin status', Science Advances, 7, http://dx.doi.org/10.1126/sciadv.abh0363

Journal articles | 2021

Samuel M; Fonseka P; Sanwlani R; Gangoda L; Chee SH; Keerthikumar S; Spurling A; Chitti SV; Zanker D; Ang CS; Atukorala I; Kang T; Shahi S; Marzan AL; Nedeva C; Vennin C; Lucas MC; Cheng L; Herrmann D; Pathan M; Chisanga D; Warren SC; Zhao K; Abraham N; Anand S; Boukouris S; Adda CG; Jiang L; Shekhar TM; Baschuk N; Hawkins CJ; Johnston AJ; Orian JM; Hoogenraad NJ; Poon IK; Hill AF; Jois M; Timpson P; Parker BS; Mathivanan S, 2021, 'Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis', Nature Communications, 12, http://dx.doi.org/10.1038/s41467-021-24273-8

Journal articles | 2021

Sharbeen G; McCarroll JA; Akerman A; Kopecky C; Youkhana J; Kokkinos J; Holst J; Boyer C; Erkan M; Goldstein D; Timpson P; Cox TR; Pereira BA; Chitty JL; Fey SK; Najumudeen AK; Campbell AD; Sansom OJ; Ignacio RMC; Naim S; Liu J; Russia N; Lee J; Chou A; Johns A; Gill AJ; Gonzales-Aloy E; Gebski V; Guan YF; Pajic M; Turner N; Apte MV; Davis TP; Morton JP; Haghighi KS; Kasparian J; McLean BJ; Setargew YF; Phillips PA, 2021, 'Cancer-associated fibroblasts in pancreatic ductal adenocarcinoma determine response to slc7a11 inhibition', Cancer Research, 81, pp. 3461 - 3479, http://dx.doi.org/10.1158/0008-5472.CAN-20-2496

Journal articles | 2020

Castillo L; Young AIJ; Mawson A; Schafranek P; Steinmann AM; Nessem D; Parkin A; Johns A; Chou A; Law AMK; Lucas MC; Murphy KJ; Deng N; Gallego-Ortega D; Caldon CE; Timpson P; Pajic M; Ormandy CJ; Oakes SR, 2020, 'MCL-1 antagonism enhances the anti-invasive effects of dasatinib in pancreatic adenocarcinoma', Oncogene, 39, pp. 1821 - 1829, http://dx.doi.org/10.1038/s41388-019-1091-0

Journal articles | 2020

Dreyer SB; Pinese M; Jamieson NB; Scarlett CJ; Colvin EK; Pajic M; Johns AL; Humphris JL; Wu J; Cowley MJ; Chou A; Nagrial AM; Chantrill L; Chin VT; Jones MD; Moran-Jones K; Carter CR; Dickson EJ; Samra JS; Merrett ND; Gill AJ; Kench JG; Duthie F; Miller DK; Cooke S; Aust D; Knösel T; Rümmele P; Grützmann R; Pilarsky C; Nguyen NQ; Musgrove EA; Bailey PJ; McKay CJ; Biankin AV; Chang DK; Australian Pancreatic Cancer Genome Initiative ; Glasgow Precision Oncology Laboratory , 2020, 'Precision Oncology in Surgery: Patient Selection for Operable Pancreatic Cancer.', Ann Surg, 272, pp. 366 - 376, http://dx.doi.org/10.1097/SLA.0000000000003143

Journal articles | 2020

Dreyer SB; Pinese M; Jamieson NB; Scarlett CJ; Colvin EK; Pajic M; Johns AL; Humphris JL; Wu J; Cowley MJ; Chou A; Nagrial AM; Chantrill L; Chin VT; Jones MD; Moran-Jones K; Carter CR; Dickson EJ; Samra JS; Merrett ND; Gill AJ; Kench JG; Duthie F; Miller DK; Cooke S; Aust D; Knösel T; Rümmele P; Grützmann R; Pilarsky C; Nguyen NQ; Musgrove EA; Bailey PJ; McKay CJ; Biankin AV; Chang DK, 2020, 'Precision Oncology in Surgery: Patient Selection for Operable Pancreatic Cancer', Annals of Surgery, 272, pp. 366 - 376, http://dx.doi.org/10.1097/SLA.0000000000003143

Journal articles | 2020

Follain G; Herrmann D; Harlepp S; Hyenne V; Osmani N; Warren SC; Timpson P; Goetz JG, 2020, 'Fluids and their mechanics in tumour transit: shaping metastasis', Nature Reviews Cancer, 20, pp. 107 - 124, http://dx.doi.org/10.1038/s41568-019-0221-x

Journal articles | 2020

Nobis M; Herrmann D; Warren SC; Strathdee D; Cox TR; Anderson KI; Timpson P, 2020, 'Shedding new light on RhoA signalling as a drug target in vivo using a novel RhoA-FRET biosensor mouse', Small GTPases, 11, pp. 240 - 247, http://dx.doi.org/10.1080/21541248.2018.1438024

Journal articles | 2020

Wang K; Zhan Y; Huynh N; Dumesny C; Wang X; Asadi K; Herrmann D; Timpson P; Yang Y; Walsh K; Baldwin GS; Nikfarjam M; He H, 2020, 'Inhibition of PAK1 suppresses pancreatic cancer by stimulation of anti-tumour immunity through down-regulation of PD-L1', Cancer Letters, 472, pp. 8 - 18, http://dx.doi.org/10.1016/j.canlet.2019.12.020

Journal articles | 2019

Conway JR; Herrmann D; Evans TJ; Morton JP; Timpson P, 2019, 'Combating pancreatic cancer with PI3K pathway inhibitors in the era of personalised medicine', Gut, 68, pp. 742 - 758, http://dx.doi.org/10.1136/gutjnl-2018-316822

Journal articles | 2019

Kawai M; Herrmann D; Fuchs A; Cheng S; Ferrer-Vaquer A; Götz R; Driller K; Neubüser A; Ohura K, 2019, 'Fgfr1 conditional-knockout in neural crest cells induces heterotopic chondrogenesis and osteogenesis in mouse frontal bones', Medical Molecular Morphology, 52, pp. 156 - 163, http://dx.doi.org/10.1007/s00795-018-0213-z

Journal articles | 2019

Pereira BA; Vennin C; Papanicolaou M; Chambers CR; Herrmann D; Morton JP; Cox TR; Timpson P, 2019, 'CAF Subpopulations: A New Reservoir of Stromal Targets in Pancreatic Cancer', Trends in Cancer, 5, pp. 724 - 741, http://dx.doi.org/10.1016/j.trecan.2019.09.010

Journal articles | 2019

Vennin C; Mélénec P; Rouet R; Nobis M; Cazet AS; Murphy KJ; Herrmann D; Reed DA; Lucas MC; Warren SC; Elgundi Z; Pinese M; Kalna G; Roden D; Samuel M; Zaratzian A; Grey ST; Da Silva A; Leung W; Johns AL; Chantrill LA; Chou A; Steinmann A; Arshi M; Dwarte T; Froio D; Pereira B; Ritchie S; Chambers CR; Metcalf X; Waddell N; Pearson JV; Patch AM; Nones K; Newell F; Mukhopadhyay P; Addala V; Kazakoff S; Holmes O; Leonard C; Wood S; Grimmond SM; Hofmann O; Christ A; Bruxner T; Samra JS; Pavlakis N; High HA; Asghari R; Merrett ND; Pavey D; Das A; Cosman PH; Ismail K; O’Connnor C; Stoita A; Williams D; Spigellman A; Lam VW; McLeod D; Kirk J; Kench JG; Grimison P; Cooper CL; Sandroussi C; Goodwin A; Mead RS; Tucker K; Andrews L; Texler M; Forest C; Epari KP; Ballal M; Fletcher DR; Mukhedkar S; Zeps N; Beilin M; Feeney K; Nguyen NQ; Ruszkiewicz AR; Worthley C; Chen J; Brooke-Smith ME; Papangelis V; Clouston AD; Barbour AP; O’Rourke TJ; Fawcett JW; Slater K; Hatzifotis M; Hodgkinson P; Nikfarjam M; Eshleman JR; Hruban RH; Wolfgang CL; Lawlor RT; Beghelli S; Corbo V; Scardoni M; Bassi C; Christ D; Cox T; Timpson P; Phillips P; Whitelock J; Pajic M; Gill A; Croucher D, 2019, 'CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan', Nature Communications, 10, pp. 3637, http://dx.doi.org/10.1038/s41467-019-10968-6

Journal articles | 2018

Benthani F; Herrman D; Tran P; Pangon L; Currey N; Lucas M; Allam A; Giry-Laterriere M; Al-Sohaily S; Timpson P; Kohonen-Corish M, 2018, 'Mutated in colorectal cancer protein strengthens the intercellular adhesion of colon cancer cells by complexing with E-cadherin and beta-catenin', Oncogene

Journal articles | 2018

Cazet AS; Hui MN; Elsworth BL; Wu SZ; Roden D; Chan CL; Skhinas JN; Collot R; Yang J; Harvey K; Johan MZ; Cooper C; Nair R; Herrmann D; McFarland A; Deng N; Ruiz-Borrego M; Rojo F; Trigo JM; Bezares S; Caballero R; Lim E; Timpson P; O’Toole S; Watkins DN; Cox TR; Samuel MS; Martín M; Swarbrick A; O'Toole S, 2018, 'Targeting stromal remodeling and cancer stem cell plasticity overcomes chemoresistance in triple negative breast cancer', Nature Communications, 9, pp. 2897, http://dx.doi.org/10.1038/s41467-018-05220-6

Journal articles | 2018

Chitty JL; Filipe EC; Lucas MC; Herrmann D; Cox TR; Timpson P, 2018, 'Recent advances in understanding the complexities of metastasis', F1000Research, 7, http://dx.doi.org/10.12688/f1000research.15064.2

Journal articles | 2018

Conway JRW; Warren SC; Herrmann D; Murphy KJ; Cazet AS; Vennin C; Shearer RF; Killen MJ; Magenau A; Mélénec P; Pinese M; Nobis M; Zaratzian A; Boulghourjian A; Da Silva AM; del Monte-Nieto G; Adam ASA; Harvey RP; Haigh JJ; Wang Y; Croucher DR; Sansom OJ; Pajic M; Caldon CE; Morton JP; Timpson P; del Monte Nieto G; Gallego-Ortega D, 2018, 'Intravital Imaging to Monitor Therapeutic Response in Moving Hypoxic Regions Resistant to PI3K Pathway Targeting in Pancreatic Cancer', Cell Reports, 23, pp. 3312 - 3326, http://dx.doi.org/10.1016/j.celrep.2018.05.038

Journal articles | 2018

Kohonen-Corish M; Benthani F; Herrmann D; Phuong T; Currey N; Lucas M; Allam A; Al-Sohaily S; Warusavitarne J; Timpson P, 2018, 'PO-168 Loss of the MCC gene expression promotes invasiveness of colon cancer cells', ESMO Open, 3, pp. A86 - A87, http://dx.doi.org/10.1136/esmoopen-2018-eacr25.207

Journal articles | 2018

Murphy K; Vennin C; Cox T; Wang Y; Morton J; Sansom O; Pajic M; Herrmann D; Timpson P, 2018, 'PO-229 Transient tissue ‘priming’ via FAK inhibition to impair pancreatic ductal adenocarcinoma (PDAC) progression to improve sensitivity to gemcitabine/abraxane', ESMO Open, 3, pp. A316 - A317, http://dx.doi.org/10.1136/esmoopen-2018-eacr25.746

Journal articles | 2018

Nobis M; Warren SC; Lucas MC; Murphy KJ; Herrmann D; Timpson P, 2018, 'Molecular mobility and activity in an intravital imaging setting - Implications for cancer progression and targeting', Journal of Cell Science, 131, http://dx.doi.org/10.1242/jcs.206995

Journal articles | 2018

Pinho AV; Van Bulck M; Chantrill L; Arshi M; Sklyarova T; Herrmann D; Vennin C; Gallego-Ortega D; Mawson A; Giry-Laterriere M; Magenau A; Leuckx G; Baeyens L; Gill AJ; Phillips P; Timpson P; Biankin AV; Wu J; Rooman I, 2018, 'ROBO2 is a stroma suppressor gene in the pancreas and acts via TGF-β signalling', Nature Communications, 9, http://dx.doi.org/10.1038/s41467-018-07497-z

Journal articles | 2018

Warren SC; Nobis M; Magenau A; Mohammed YH; Herrmann D; Moran I; Vennin C; Conway JRW; Mélénec P; Cox TR; Wang Y; Morton JP; Welch HCE; Strathdee D; Anderson KI; Phan TG; Roberts MS; Timpson P, 2018, 'Removing physiological motion from Intravital and clinical functional imaging data', eLife, 7, http://dx.doi.org/10.7554/eLife.35800

Journal articles | 2018

Firatligil B; Bati-Ayaz G; Pesen-Okvur D; Yalcin-Ozuysal O, 2018, 'PO-171 Tissue specific extravasation and invasion of MDA-MB-231 cells in a lab-on-a-chip system', ESMO Open, vol. 3, pp. A88 - A88, http://dx.doi.org/10.1136/esmoopen-2018-eacr25.210

Journal articles | 2017

Balachandran VP; Łuksza M; Zhao JN; Makarov V; Moral JA; Remark R; Herbst B; Askan G; Bhanot U; Senbabaoglu Y; Wells DK; Cary CIO; Grbovic-Huezo O; Attiyeh M; Medina B; Zhang J; Loo J; Saglimbeni J; Abu-Akeel M; Zappasodi R; Riaz N; Smoragiewicz M; Larkin Kelley Z; Basturk O; Gönen M; Levine AJ; Allen PJ; Fearon DT; Merad M; Gnjatic S; Iacobuzio-Donahue CA; Wolchok JD; Dematteo RP; Chan TA; Greenbaum BD; Merghoub T; Leach SD; Johns AL; Scott Mead R; Gill AJ; Chang DK; McKay SH; Chantrill LA; Chin VT; Chou A; Humphris JL; Pajic M; Steinmann A; Arshi M; Drury A; Froio D; Morgan A; Timpson P; Hermann D; Vennin C; Warren S; Pinese M; Wu J; Pinho AV; Tucker K; Andrews L; Samra JS; Arena J; Pavlakis N; High HA; Mittal A; Biankin AV; Bailey P; Martin S; Musgrove EA; Jones MD; Nourse C; Jamieson NB; Stoita A; Williams D; Spigelman A; Waddell N; Pearson JV; Patch AM; Nones K; Newell F; Mukhopadhyay P; Addala V; Kazakoff S; Holmes O; Leonard C; Wood S; Xu C; Grimmond SM; Hofmann O; Wilson PJ; Christ A; Bruxner T; Asghari R; Merrett ND; Pavey D; Das A; Goodwin A; Cosman PH; Ismail K, 2017, 'Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer', Nature, 551, pp. S12 - S16, http://dx.doi.org/10.1038/nature24462

Journal articles | 2017

Conway JRW; Vennin C; Cazet AS; Herrmann D; Murphy KJ; Warren SC; Wullkopf L; Boulghourjian A; Zaratzian A; Da Silva AM; Pajic M; Morton JP; Cox TR; Timpson P, 2017, 'Three-dimensional organotypic matrices from alternative collagen sources as pre-clinical models for cell biology', Scientific Reports, 7, pp. 16887, http://dx.doi.org/10.1038/s41598-017-17177-5

Journal articles | 2017

Harris NLE; Vennin C; Conway JRW; Vine KL; Pinese M; Cowley MJ; Shearer RF; Lucas MC; Herrmann D; Allam AH; Pajic M; Morton JP; Biankin AV; Ranson M; Timpson P; Saunders DN, 2017, 'SerpinB2 regulates stromal remodelling and local invasion in pancreatic cancer', Oncogene, 36, pp. 4288 - 4298, http://dx.doi.org/10.1038/onc.2017.63

Journal articles | 2017

Herrmann D; Erami Z; Warren S; Nobis M; Magenau A; Lucas M; Vennin C; McGhee EJ; Leung W; Reischmann N; Mrowinska A; Schwarz JP; Kadir S; Karim SA; Campbell AD; Gallego-Ortega D; Evans J; Sansom OJ; Morton JP; Anderson KI; Timpson P, 2017, 'A biosensor mouse to predict the dissociation and spread of pancreatic cancer', CANCER RESEARCH, 77, http://dx.doi.org/10.1158/1538-7445.EPSO16-PR07

Journal articles | 2017

Johns AL; McKay SH; Humphris JL; Pinese M; Chantrill LA; Mead RS; Tucker K; Andrews L; Goodwin A; Leonard C; High HA; Nones K; Waddell N; Patch AM; Merrett ND; Pavlakis N; Kassahn KS; Samra JS; Miller DK; Chang DK; Pajic M; Pearson JV; Grimmond SM; Zeps N; Gill AJ; Biankin AV; Chin VT; Chou A; Steinmann A; Arshi M; Drury A; Froio D; Morgan A; Timpson P; Hermann D; Vennin C; Warren S; Wu J; Pinho AV; Newell F; Mukhopadhyay P; Addala V; Kazakoff S; Holmes O; Wood S; Xu C; Hofmann O; Wilson PJ; Christ A; Bruxner T; Samra S; Arena J; Mittal A; Asghari R; Pavey D; Das A; Cosman PH; Ismail K; O'Connnor C; Williams D; Spigellman A; Lam W; McLeod D; Nagrial AM; Kirk J; James V; Grimison P; Cooper CL; Sandroussi C; Forest C; Epari KP; Ballal M; Fletcher DR; Mukhedkar S; Beilin M; Feeney K; Nguyen NQ; Ruszkiewicz AR; Worthley C; Brooke-Smith ME; Papangelis V; Clouston AD; Martin P; Barbour AP; O'Rourke TJ; Fawcett JW; Slater K; Hatzifotis M; Hodgkinson P; Hruban RH; Wolfgang CL; Hodgin M; Lawlor RT; Beghelli S; Corbo V; Scardoni M; Bassi C; Bailey P; Martin S; Musgrove EA; Herrmann D, 2017, 'Lost in translation: Returning germline genetic results in genome-scale cancer research', Genome Medicine, 9, pp. 41, http://dx.doi.org/10.1186/s13073-017-0430-4

Journal articles | 2017

Nobis M; Herrmann D; Warren SC; Kadir S; Leung W; Killen M; Magenau A; Stevenson D; Lucas MC; Reischmann N; Vennin C; Conway JRW; Boulghourjian A; Zaratzian A; Law AM; Gallego-Ortega D; Ormandy CJ; Walters SN; Grey ST; Bailey J; Chtanova T; Quinn JMW; Baldock PA; Croucher PI; Schwarz JP; Mrowinska A; Zhang L; Herzog H; Masedunskas A; Hardeman EC; Gunning PW; del Monte-Nieto G; Harvey RP; Samuel MS; Pajic M; McGhee EJ; Johnsson AKE; Sansom OJ; Welch HCE; Morton JP; Strathdee D; Anderson KI; Timpson P; del Monte Nieto G, 2017, 'A RhoA-FRET Biosensor Mouse for Intravital Imaging in Normal Tissue Homeostasis and Disease Contexts', Cell Reports, 21, pp. 274 - 288, http://dx.doi.org/10.1016/j.celrep.2017.09.022

Journal articles | 2017

Vennin C; Chin VT; Warren SC; Lucas MC; Herrmann D; Magenau A; Melenec P; Walters SN; Del Monte-Nieto G; Conway JRW; Nobis M; Allam AH; McCloy RA; Currey N; Pinese M; Boulghourjian A; Zaratzian A; Adam AAS; Heu C; Nagrial AM; Chou A; Steinmann A; Drury A; Froio D; Giry-Laterriere M; Harris NLE; Phan T; Jain R; Weninger W; McGhee EJ; Whan R; Johns AL; Samra JS; Chantrill L; Gill AJ; Kohonen-Corish M; Harvey RP; Biankin AV; Evans TRJ; Anderson KI; Grey ST; Ormandy CJ; Gallego-Ortega D; Wang Y; Samuel MS; Sansom OJ; Burgess A; Cox TR; Morton JP; Pajic M; Timpson P, 2017, 'Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis', Science Translational Medicine, 9, http://dx.doi.org/10.1126/scitranslmed.aai8504

Journal articles | 2016

Erami Z; Herrmann D; Warren SC; Nobis M; McGhee EJ; Lucas MC; Leung W; Reischmann N; Mrowinska A; Schwarz JP; Kadir S; Conway JRW; Vennin C; Karim SA; Campbell AD; Gallego-Ortega D; Magenau A; Murphy KJ; Ridgway RA; Law AM; Walters SN; Grey ST; Croucher DR; Zhang L; Herzog H; Hardeman EC; Gunning PW; Ormandy CJ; Evans TRJ; Strathdee D; Sansom OJ; Morton JP; Anderson KI; Timpson P; Zhang L, 2016, 'Intravital FRAP Imaging using an E-cadherin-GFP Mouse Reveals Disease- and Drug-Dependent Dynamic Regulation of Cell-Cell Junctions in Live Tissue', Cell Reports, 14, pp. 152 - 167, http://dx.doi.org/10.1016/j.celrep.2015.12.020

Journal articles | 2016

Nobis M; Herrmann D; Timpson P; Erami Z; Anderson K, 2016, 'Imaging Molecular Dynamics for Drug Discovery', Physiology News, pp. 27 - 29, http://dx.doi.org/10.36866/pn.104.27

Journal articles | 2016

Vennin C; Herrmann D; Lucas MC; Timpson P, 2016, 'Intravital imaging reveals new ancillary mechanisms co-opted by cancer cells to drive tumor progression.', F1000Research, 5, http://dx.doi.org/10.12688/F1000RESEARCH.8090.1

Journal articles | 2016

Young AIJ; Law AMK; Castillo L; Chong S; Cullen HD; Koehler M; Herzog S; Brummer T; Lee EF; Fairlie WD; Lucas MC; Herrmann D; Allam A; Timpson P; Watkins DN; Millar EKA; O'Toole SA; Gallego-Ortega D; Ormandy CJ; Oakes SR, 2016, 'MCL-1 inhibition provides a new way to suppress breast cancer metastasis and increase sensitivity to dasatinib', Breast Cancer Research, 18, http://dx.doi.org/10.1186/s13058-016-0781-6

Journal articles | 2015

Belle L; Ali N; Lonic A; Li X; Paltridge JL; Roslan S; Herrmann D; Conway JRW; Gehling FK; Bert AG; Crocker LA; Tsykin A; Farshid G; Goodall GJ; Timpson P; Daly RJ; Khew-Goodall Y, 2015, 'The tyrosine phosphatase PTPN14 (Pez) inhibits metastasis by altering protein trafficking', Science Signaling, 8, http://dx.doi.org/10.1126/scisignal.2005547

Journal articles | 2015

Gallego-Ortega D; Ledger A; Roden DL; Law AMK; Magenau A; Kikhtyak Z; Cho C; Allerdice SL; Lee HJ; Valdes-Mora F; Herrmann D; Salomon R; Young AIJ; Lee BY; Sergio CM; Kaplan W; Piggin C; Conway JRW; Rabinovich B; Millar EKA; Oakes SR; Chtanova T; Swarbrick A; Naylor MJ; O’Toole S; Green AR; Timpson P; Gee JMW; Ellis IO; Clark SJ; Ormandy CJ, 2015, 'ELF5 Drives Lung Metastasis in Luminal Breast Cancer through Recruitment of Gr1+ CD11b+ Myeloid-Derived Suppressor Cells', PLoS Biology, 13, http://dx.doi.org/10.1371/journal.pbio.1002330

Journal articles | 2015

Pajic M; Herrmann D; Vennin C; Conway JRW; Chin VT; Johnsson AKE; Welch HCE; Timpson P, 2015, 'The dynamics of Rho GTPase signaling and implications for targeting cancer and the tumor microenvironment', Small GTPases, 6, pp. 123 - 133, http://dx.doi.org/10.4161/21541248.2014.973749

Journal articles | 2014

Herrmann D; Conway JRW; Vennin C; Magenau A; Hughes WG; Morton JP; Timpson P, 2014, 'Three-dimensional cancer models mimic cell-matrix interactions in the tumour microenvironment', Carcinogenesis, 35, pp. 1671 - 1679, http://dx.doi.org/10.1093/carcin/bgu108

Journal articles | 2014

Nobis M; McGhee EJ; Herrmann D; Magenau A; Morton JP; Anderson KI; Timpson P, 2014, 'Monitoring the dynamics of Src activity in response to anti-invasive dasatinib treatment at a subcellular level using dual intravital imaging', Cell Adhesion and Migration, 8, pp. 478 - 486, http://dx.doi.org/10.4161/19336918.2014.970004

Journal articles | 2010

Fuchs A; Inthal A; Herrmann D; Cheng S; Nakatomi M; Peters H; Neubüser A, 2010, 'Regulation of Tbx22 during facial and palatal development', Developmental Dynamics, 239, pp. 2860 - 2874, http://dx.doi.org/10.1002/dvdy.22421

Journal articles | 2010

Herrmann D; Ferrer-Vaquer A; Lahsnig C; Firnberg N; Leibbrandt A; Neubüser A, 2010, 'Expression and regulation of ANTXR1 in the chick embryo', Developmental Dynamics, 239, pp. 688 - 702, http://dx.doi.org/10.1002/dvdy.22196
Conference Papers | 2019

Pinho AV; Van Bulck M; Chantrill L; Arshi M; Herrmann D; Vennin C, 2019, 'ROBO2 is a stroma suppressor gene in the pancreas through regulation of TGF-beta', in CANCER IMMUNOLOGY RESEARCH, AMER ASSOC CANCER RESEARCH, http://dx.doi.org/10.1158/2326-6074.CRICIMTEATIAACR18-A100

Conference Abstracts | 2018

Pinho AV; Bulck MV; Chantrill L; Arshi M; Sklyarova T; Herrmann D; Vennin C; Gallego-Ortega D; Mawson A; Giry-Laterriere M; Magenau A; Baeyens L; Gill AJ; Phillips P; Timpson P; Biankin AV; Wu J; Rooman I, 2018, 'ROBO2 is a Stroma Suppressor Gene in the Pancreas Through Regulation of TGF-beta', in PANCREAS, LIPPINCOTT WILLIAMS & WILKINS, Vol. 47, pp. 1417 - 1417, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000449304600212&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Papers | 2018

Warren SC; Magenau A; Nobis M; Herrmann D; Mélénec P; Anderson KI; Sansom OJ; Morton JP; Welch HC; Timpson P, 2018, 'Unmixing spectrally overlapping FRET biosensors in vivo using multispectral FLIM (Conference Presentation)', in Periasamy A; So PT; Xie XS; König K (eds.), Multiphoton Microscopy in the Biomedical Sciences XVIII, SPIE, pp. 23 - 23, presented at Multiphoton Microscopy in the Biomedical Sciences XVIII, 27 January 2018 - 01 February 2018, http://dx.doi.org/10.1117/12.2290152

Preprints | 2017

Cazet A; Hui M; Elsworth B; Wu S; Roden D; Chan C-L; Skhinas J; Collot R; Yang J; Harvey K; Johan Z; Cooper C; Nair R; Herrmann D; McFarland A; Deng N-T; Ruiz-Borrego M; Rojo F; Trigo J; Bezares S; Caballero R; Lim E; Timpson P; O’Toole S; Watkins N; Cox T; Samuel M; Martín M; Swarbrick A, 2017, Targeting stromal remodeling and cancer stem cell plasticity to overcome chemoresistance in triple negative breast cancer, http://dx.doi.org/10.1101/215954

Conference Papers | 2009

Herrmann D; Cheng S; Driller K; Partanen J; Neubser A, 2009, 'Analysis of facial and palatal defects in Fgfr1 mutant mice', in MECHANISMS OF DEVELOPMENT, ELSEVIER SCIENCE BV, SCOTLAND, Edinburgh, pp. S166 - S166, presented at 16th Annual Conference of the International-Society-of-Development-Biologists, SCOTLAND, Edinburgh, 06 September 2009 - 10 September 2009, http://dx.doi.org/10.1016/j.mod.2009.06.384

Sydney Catalyst Pilot & Seed Funding Award, 2019, Sydney, Australia

Hunter Cell Biology F1000prime Poster Prize, 2019, Lovedale, Australia

Australian BioResources 10th Anniversary Competition Major Prize, 2018, Moss Vale, Australia

Cold Spring Harbor Laboratories Travel Stipend, 2017, Cold Spring Harbor Laboratories, New York, USA.

Young Garvan Award Finalist, 2016, Sydney, Australia.

Traveling grant from the CDB Riken Center, Japan, to attend the symposium “Frontiers in Organogenesis”, 2010, Kobe, Japan.

PhD Fellowship: GRK1104 “From Cells to Organs: Molecular Mechanisms of Organogenesis“, 2008-2010, Freiburg, Germany.

Alumni-Diploma Award, University of Freiburg, Faculty of Biology, 2008, Freiburg, Germany.

My Research Supervision

4 PhD students

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Dr David Herrmann