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Dr David Herrmann
Conjoint Senior Lecturer

Dr David Herrmann

Medicine & Health
School of Clinical Medicine
Phone
+61293555851
E-mail
d.herrmann@garvan.org.au
Location
Garvan Institute of Medical Research / The Kinghorn Cancer Centre Darlinghurst
  • Journal articles | 2023
    2023, 'Monitoring AKT activity and targeting in live tissue and disease contexts using a real-time Akt-FRET biosensor mouse.', Sci Adv, 9, pp. eadf9063, http://dx.doi.org/10.1126/sciadv.adf9063
    Journal articles | 2022
    2022, 'Cell-derived Matrix Assays to Assess Extracellular Matrix Architecture and Track Cell Movement', Bio-protocol, 12, http://dx.doi.org/10.21769/BioProtoc.4570
    Journal articles | 2022
    2022, 'Focal adhesion kinase priming in pancreatic cancer, altering biomechanics to improve chemotherapy', Biochemical Society Transactions, 50, pp. 1129 - 1141, http://dx.doi.org/10.1042/BST20220162
    Journal articles | 2022
    2022, 'Genomic and Molecular Analyses Identify Molecular Subtypes of Pancreatic Cancer Recurrence', Gastroenterology, 162, pp. 320 - 324.e4, http://dx.doi.org/10.1053/j.gastro.2021.09.022
    Journal articles | 2022
    2022, 'Multiphoton intravital microscopy of rodents', Nature Reviews Methods Primers, 2, http://dx.doi.org/10.1038/s43586-022-00168-w
    Journal articles | 2022
    2022, 'Temporal profiling of the breast tumour microenvironment reveals collagen XII as a driver of metastasis', Nature Communications, 13, pp. 4587, http://dx.doi.org/10.1038/s41467-022-32255-7
    Journal articles | 2021
    2021, 'Cancer-associated fibroblasts in pancreatic ductal adenocarcinoma determine response to slc7a11 inhibition', Cancer Research, 81, pp. 3461 - 3479, http://dx.doi.org/10.1158/0008-5472.CAN-20-2496
    Journal articles | 2021
    2021, 'DNA methylation patterns identify subgroups of pancreatic neuroendocrine tumors with clinical association', Communications Biology, 4, http://dx.doi.org/10.1038/s42003-020-01469-0
    Journal articles | 2021
    2021, 'Dynamic stromal alterations influence tumor-stroma crosstalk to promote pancreatic cancer and treatment resistance', Cancers, 13, http://dx.doi.org/10.3390/cancers13143481
    Journal articles | 2021
    2021, 'Intravital imaging technology guides FAK-mediated priming in pancreatic cancer precision medicine according to Merlin status', Science Advances, 7, http://dx.doi.org/10.1126/sciadv.abh0363
    Journal articles | 2021
    2021, 'Optimizing metastatic-cascade-dependent Rac1 targeting in breast cancer: Guidance using optical window intravital FRET imaging', Cell Reports, 36, http://dx.doi.org/10.1016/j.celrep.2021.109689
    Journal articles | 2021
    2021, 'Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis', Nature Communications, 12, pp. 3950, http://dx.doi.org/10.1038/s41467-021-24273-8
    Journal articles | 2021
    2021, 'Quantifying and visualising the nuances of cellular dynamics in vivo using intravital imaging', Current Opinion in Cell Biology, 72, pp. 41 - 53, http://dx.doi.org/10.1016/j.ceb.2021.04.007
    Journal articles | 2021
    2021, 'ROR1 and ROR2 expression in pancreatic cancer', BMC Cancer, 21, pp. 1199, http://dx.doi.org/10.1186/s12885-021-08952-9
    Journal articles | 2020
    Nobis M; Herrmann D; Warren SC; Strathdee D; Cox TR; Anderson KI; Timpson P, 2020, 'Shedding new light on RhoA signalling as a drug target in vivo using a novel RhoA-FRET biosensor mouse', Small GTPases, 11, pp. 240 - 247, http://dx.doi.org/10.1080/21541248.2018.1438024
    Journal articles | 2020
    2020, 'Fluids and their mechanics in tumour transit: shaping metastasis', Nature Reviews Cancer, 20, pp. 107 - 124, http://dx.doi.org/10.1038/s41568-019-0221-x
    Journal articles | 2020
    2020, 'Inhibition of PAK1 suppresses pancreatic cancer by stimulation of anti-tumour immunity through down-regulation of PD-L1', Cancer Letters, 472, pp. 8 - 18, http://dx.doi.org/10.1016/j.canlet.2019.12.020
    Journal articles | 2020
    2020, 'MCL-1 antagonism enhances the anti-invasive effects of dasatinib in pancreatic adenocarcinoma', Oncogene, 39, pp. 1821 - 1829, http://dx.doi.org/10.1038/s41388-019-1091-0
    Journal articles | 2020
    2020, 'Precision Oncology in Surgery: Patient Selection for Operable Pancreatic Cancer', Annals of surgery, 272, pp. 366 - 376, http://dx.doi.org/10.1097/SLA.0000000000003143
    Journal articles | 2020
    2020, 'Precision Oncology in Surgery: Patient Selection for Operable Pancreatic Cancer.', Ann Surg, 272, pp. 366 - 376, http://dx.doi.org/10.1097/SLA.0000000000003143
    Journal articles | 2019
    2019, 'CAF Subpopulations: A New Reservoir of Stromal Targets in Pancreatic Cancer', Trends in Cancer, 5, pp. 724 - 741, http://dx.doi.org/10.1016/j.trecan.2019.09.010
    Journal articles | 2019
    2019, 'CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan', Nature Communications, 10, pp. 3637, http://dx.doi.org/10.1038/s41467-019-10968-6
    Journal articles | 2019
    2019, 'Combating pancreatic cancer with PI3K pathway inhibitors in the era of personalised medicine', Gut, 68, pp. 742 - 758, http://dx.doi.org/10.1136/gutjnl-2018-316822
    Journal articles | 2019
    2019, 'Fgfr1 conditional-knockout in neural crest cells induces heterotopic chondrogenesis and osteogenesis in mouse frontal bones', Medical Molecular Morphology, 52, pp. 156 - 163, http://dx.doi.org/10.1007/s00795-018-0213-z
    Journal articles | 2018
    Cazet AS; Hui MN; Elsworth BL; Wu SZ; Roden D; Chan CL; Skhinas JN; Collot R; Yang J; Harvey K; Johan MZ; Cooper C; Nair R; Herrmann D; McFarland A; Deng N; Ruiz-Borrego M; Rojo F; Trigo JM; Bezares S; Caballero R; Lim E; Timpson P; O’Toole S; Watkins DN; Cox TR; Samuel MS; Martín M; Swarbrick A, 2018, 'Targeting stromal remodeling and cancer stem cell plasticity overcomes chemoresistance in triple negative breast cancer', Nature Communications, 9, http://dx.doi.org/10.1038/s41467-018-05220-6
    Journal articles | 2018
    Conway JR W; Warren SC; Herrmann D; Murphy KJ; Cazet AS; Vennin C; Shearer RF; Killen MJ; Magenau A; Mélénec P; Pinese M; Nobis M; Zaratzian A; Boulghourjian A; Da Silva AM; del Monte-Nieto G; Adam AS A; Harvey RP; Haigh JJ; Wang Y; Croucher DR; Sansom OJ; Pajic M; Caldon CE; Morton JP; Timpson P, 2018, 'Intravital Imaging to Monitor Therapeutic Response in Moving Hypoxic Regions Resistant to PI3K Pathway Targeting in Pancreatic Cancer', Cell Reports, 23, pp. 3312 - 3326, http://dx.doi.org/10.1016/j.celrep.2018.05.038
    Journal articles | 2018
    Nobis M; Warren SC; Lucas MC; Murphy KJ; Herrmann D; Timpson P, 2018, 'Molecular mobility and activity in an intravital imaging setting - Implications for cancer progression and targeting', Journal of Cell Science, 131, http://dx.doi.org/10.1242/jcs.206995
    Journal articles | 2018
    Warren SC; Nobis M; Magenau A; Mohammed YH; Herrmann D; Moran I; Vennin C; Conway JR W; Mélénec P; Cox TR; Wang Y; Morton JP; Welch HC E; Strathdee D; Anderson KI; Phan TG; Roberts MS; Timpson P, 2018, 'Removing physiological motion from Intravital and clinical functional imaging data', eLife, 7, http://dx.doi.org/10.7554/eLife.35800
    Journal articles | 2018
    2018, 'Mutated in colorectal cancer protein strengthens the intercellular adhesion of colon cancer cells by complexing with E-cadherin and beta-catenin', Oncogene, 37, pp. 663 - 672, http://dx.doi.org/10.1038/onc.2017.362
    Journal articles | 2018
    2018, 'PO-168 Loss of the MCC gene expression promotes invasiveness of colon cancer cells', ESMO Open, 3, pp. A86 - A87, http://dx.doi.org/10.1136/esmoopen-2018-eacr25.207
    Journal articles | 2018
    2018, 'PO-229 Transient tissue ‘priming’ via FAK inhibition to impair pancreatic ductal adenocarcinoma (PDAC) progression to improve sensitivity to gemcitabine/abraxane', ESMO Open, 3, pp. A316 - A317, http://dx.doi.org/10.1136/esmoopen-2018-eacr25.746
    Journal articles | 2018
    2018, 'ROBO2 is a stroma suppressor gene in the pancreas and acts via TGF-β signalling', Nature Communications, 9, pp. 5083, http://dx.doi.org/10.1038/s41467-018-07497-z
    Journal articles | 2018
    2018, 'Recent advances in understanding the complexities of metastasis', F1000Research, 7, http://dx.doi.org/10.12688/f1000research.15064.2
    Journal articles | 2018
    Firatligil B; Bati-Ayaz G; Pesen-Okvur D; Yalcin-Ozuysal O, 2018, 'PO-171 Tissue specific extravasation and invasion of MDA-MB-231 cells in a lab-on-a-chip system', ESMO Open, vol. 3, pp. A88 - A88, http://dx.doi.org/10.1136/esmoopen-2018-eacr25.210
    Journal articles | 2017
    Conway JR W; Vennin C; Cazet AS; Herrmann D; Murphy KJ; Warren SC; Wullkopf L; Boulghourjian A; Zaratzian A; Da Silva AM; Pajic M; Morton JP; Cox TR; Timpson P, 2017, 'Three-dimensional organotypic matrices from alternative collagen sources as pre-clinical models for cell biology', Scientific Reports, 7, http://dx.doi.org/10.1038/s41598-017-17177-5
    Journal articles | 2017
    Harris NL E; Vennin C; Conway JR W; Vine KL; Pinese M; Cowley MJ; Shearer RF; Lucas MC; Herrmann D; Allam AH; Pajic M; Morton JP; Biankin AV; Ranson M; Timpson P; Saunders DN, 2017, 'SerpinB2 regulates stromal remodelling and local invasion in pancreatic cancer', Oncogene, 36, pp. 4288 - 4298, http://dx.doi.org/10.1038/onc.2017.63
    Journal articles | 2017
    Herrmann D; Erami Z; Warren S; Nobis M; Magenau A; Lucas M; Vennin C; McGhee EJ; Leung W; Reischmann N; Mrowinska A; Schwarz JP; Kadir S; Karim SA; Campbell AD; Gallego-Ortega D; Evans J; Sansom OJ; Morton JP; Anderson KI; Timpson P, 2017, 'A biosensor mouse to predict the dissociation and spread of pancreatic cancer', CANCER RESEARCH, 77, http://dx.doi.org/10.1158/1538-7445.EPSO16-PR07
    Journal articles | 2017
    Johns AL; McKay SH; Humphris JL; Pinese M; Chantrill LA; Mead RS; Tucker K; Andrews L; Goodwin A; Leonard C; High HA; Nones K; Waddell N; Patch AM; Merrett ND; Pavlakis N; Kassahn KS; Samra JS; Miller DK; Chang DK; Pajic M; Pearson JV; Grimmond SM; Zeps N; Gill AJ; Biankin AV; Chin VT; Chou A; Steinmann A; Arshi M; Drury A; Froio D; Morgan A; Timpson P; Hermann D; Vennin C; Warren S; Wu J; Pinho AV; Newell F; Mukhopadhyay P; Addala V; Kazakoff S; Holmes O; Wood S; Xu C; Hofmann O; Wilson PJ; Christ A; Bruxner T; Samra S; Arena J; Mittal A; Asghari R; Pavey D; Das A; Cosman PH; Ismail K; O'Connnor C; Williams D; Spigellman A; Lam W; McLeod D; Nagrial AM; Kirk J; James V; Grimison P; Cooper CL; Sandroussi C; Forest C; Epari KP; Ballal M; Fletcher DR; Mukhedkar S; Beilin M; Feeney K; Nguyen NQ; Ruszkiewicz AR; Worthley C; Brooke-Smith ME; Papangelis V; Clouston AD; Martin P; Barbour AP; O'Rourke TJ; Fawcett JW; Slater K; Hatzifotis M; Hodgkinson P; Hruban RH; Wolfgang CL; Hodgin M; Lawlor RT; Beghelli S; Corbo V; Scardoni M; Bassi C; Bailey P; Martin S; Musgrove EA, 2017, 'Lost in translation: Returning germline genetic results in genome-scale cancer research', Genome Medicine, 9, http://dx.doi.org/10.1186/s13073-017-0430-4
    Journal articles | 2017
    Nobis M; Herrmann D; Warren SC; Kadir S; Leung W; Killen M; Magenau A; Stevenson D; Lucas MC; Reischmann N; Vennin C; Conway JR W; Boulghourjian A; Zaratzian A; Law AM; Gallego-Ortega D; Ormandy CJ; Walters SN; Grey ST; Bailey J; Chtanova T; Quinn JM W; Baldock PA; Croucher PI; Schwarz JP; Mrowinska A; Zhang L; Herzog H; Masedunskas A; Hardeman EC; Gunning PW; del Monte-Nieto G; Harvey RP; Samuel MS; Pajic M; McGhee EJ; Johnsson AK E; Sansom OJ; Welch HC E; Morton JP; Strathdee D; Anderson KI; Timpson P, 2017, 'A RhoA-FRET Biosensor Mouse for Intravital Imaging in Normal Tissue Homeostasis and Disease Contexts', Cell Reports, 21, pp. 274 - 288, http://dx.doi.org/10.1016/j.celrep.2017.09.022
    Journal articles | 2017
    Vennin C; Chin VT; Warren SC; Lucas MC; Herrmann D; Magenau A; Melenec P; Walters SN; Del Monte-Nieto G; Conway JR W; Nobis M; Allam AH; McCloy RA; Currey N; Pinese M; Boulghourjian A; Zaratzian A; Adam AA S; Heu C; Nagrial AM; Chou A; Steinmann A; Drury A; Froio D; Giry-Laterriere M; Harris NL E; Phan T; Jain R; Weninger W; McGhee EJ; Whan R; Johns AL; Samra JS; Chantrill L; Gill AJ; Kohonen-Corish M; Harvey RP; Biankin AV; Evans TR J; Anderson KI; Grey ST; Ormandy CJ; Gallego-Ortega D; Wang Y; Samuel MS; Sansom OJ; Burgess A; Cox TR; Morton JP; Pajic M; Timpson P, 2017, 'Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis', Science Translational Medicine, 9, http://dx.doi.org/10.1126/scitranslmed.aai8504
    Journal articles | 2017
    2017, 'Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer', Nature, 551, pp. S12 - S16, http://dx.doi.org/10.1038/nature24462
    Journal articles | 2016
    Vennin C; Herrmann D; Lucas MC; Timpson P, 2016, 'Intravital imaging reveals new ancillary mechanisms co-opted by cancer cells to drive tumor progression [version 1; referees: 2 approved]', F1000Research, 5, http://dx.doi.org/10.12688/F1000RESEARCH.8090.1
    Journal articles | 2016
    Young AI J; Law AM K; Castillo L; Chong S; Cullen HD; Koehler M; Herzog S; Brummer T; Lee EF; Fairlie WD; Lucas MC; Herrmann D; Allam A; Timpson P; Watkins DN; Millar EK A; O'Toole SA; Gallego-Ortega D; Ormandy CJ; Oakes SR, 2016, 'MCL-1 inhibition provides a new way to suppress breast cancer metastasis and increase sensitivity to dasatinib', Breast Cancer Research, 18, http://dx.doi.org/10.1186/s13058-016-0781-6
    Journal articles | 2016
    2016, 'Imaging Molecular Dynamics for Drug Discovery', Physiology News, pp. 27 - 29, http://dx.doi.org/10.36866/pn.104.27
    Journal articles | 2016
    2016, 'Intravital FRAP Imaging using an E-cadherin-GFP Mouse Reveals Disease- and Drug-Dependent Dynamic Regulation of Cell-Cell Junctions in Live Tissue', Cell Reports, 14, pp. 152 - 167, http://dx.doi.org/10.1016/j.celrep.2015.12.020
    Journal articles | 2015
    Belle L; Ali N; Lonic A; Li X; Paltridge JL; Roslan S; Herrmann D; Conway JR W; Gehling FK; Bert AG; Crocker LA; Tsykin A; Farshid G; Goodall GJ; Timpson P; Daly RJ; Khew-Goodall Y, 2015, 'The tyrosine phosphatase PTPN14 (Pez) inhibits metastasis by altering protein trafficking', Science Signaling, 8, http://dx.doi.org/10.1126/scisignal.2005547
    Journal articles | 2015
    Gallego-Ortega D; Ledger A; Roden DL; Law AM K; Magenau A; Kikhtyak Z; Cho C; Allerdice SL; Lee HJ; Valdes-Mora F; Herrmann D; Salomon R; Young AI J; Lee BY; Sergio CM; Kaplan W; Piggin C; Conway JR W; Rabinovich B; Millar EK A; Oakes SR; Chtanova T; Swarbrick A; Naylor MJ; O’Toole S; Green AR; Timpson P; Gee JM W; Ellis IO; Clark SJ; Ormandy CJ, 2015, 'ELF5 Drives Lung Metastasis in Luminal Breast Cancer through Recruitment of Gr1+ CD11b+ Myeloid-Derived Suppressor Cells', PLoS Biology, 13, http://dx.doi.org/10.1371/journal.pbio.1002330
    Journal articles | 2015
    Pajic M; Herrmann D; Vennin C; Conway JR W; Chin VT; Johnsson AK E; Welch HC E; Timpson P, 2015, 'The dynamics of Rho GTPase signaling and implications for targeting cancer and the tumor microenvironment', Small GTPases, 6, pp. 123 - 133, http://dx.doi.org/10.4161/21541248.2014.973749
    Journal articles | 2014
    Herrmann D; Conway JR W; Vennin C; Magenau A; Hughes WG; Morton JP; Timpson P, 2014, 'Three-dimensional cancer models mimic cell-matrix interactions in the tumour microenvironment', Carcinogenesis, 35, pp. 1671 - 1679, http://dx.doi.org/10.1093/carcin/bgu108
    Journal articles | 2014
    Nobis M; McGhee EJ; Herrmann D; Magenau A; Morton JP; Anderson KI; Timpson P, 2014, 'Monitoring the dynamics of Src activity in response to anti-invasive dasatinib treatment at a subcellular level using dual intravital imaging', Cell Adhesion and Migration, 8, pp. 478 - 486, http://dx.doi.org/10.4161/19336918.2014.970004
    Journal articles | 2010
    Fuchs A; Inthal A; Herrmann D; Cheng S; Nakatomi M; Peters H; Neubüser A, 2010, 'Regulation of Tbx22 during facial and palatal development', Developmental Dynamics, 239, pp. 2860 - 2874, http://dx.doi.org/10.1002/dvdy.22421
    Journal articles | 2010
    Herrmann D; Ferrer-Vaquer A; Lahsnig C; Firnberg N; Leibbrandt A; Neubüser A, 2010, 'Expression and regulation of ANTXR1 in the chick embryo', Developmental Dynamics, 239, pp. 688 - 702, http://dx.doi.org/10.1002/dvdy.22196
  • Conference Papers | 2019
    2019, 'ROBO2 is a stroma suppressor gene in the pancreas through regulation of TGF-beta', in CANCER IMMUNOLOGY RESEARCH, AMER ASSOC CANCER RESEARCH, http://dx.doi.org/10.1158/2326-6074.CRICIMTEATIAACR18-A100
    Conference Abstracts | 2018
    2018, 'ROBO2 is a Stroma Suppressor Gene in the Pancreas Through Regulation of TGF-beta', in PANCREAS, LIPPINCOTT WILLIAMS & WILKINS, Vol. 47, pp. 1417 - 1417, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000449304600212&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2018
    2018, 'Unmixing spectrally overlapping FRET biosensors in vivo using multispectral FLIM (Conference Presentation)', in Periasamy A; So PT; Xie XS; König K (eds.), Multiphoton Microscopy in the Biomedical Sciences XVIII, SPIE, pp. 23, presented at Multiphoton Microscopy in the Biomedical Sciences XVIII, 27 January 2018 - 01 February 2018, http://dx.doi.org/10.1117/12.2290152
    Preprints | 2017
    2017, Targeting stromal remodeling and cancer stem cell plasticity to overcome chemoresistance in triple negative breast cancer, , http://dx.doi.org/10.1101/215954
    Conference Papers | 2009
    Herrmann D; Cheng S; Driller K; Partanen J; Neubser A, 2009, 'Analysis of facial and palatal defects in Fgfr1 mutant mice', in MECHANISMS OF DEVELOPMENT, ELSEVIER SCIENCE BV, SCOTLAND, Edinburgh, pp. S166 - S166, presented at 16th Annual Conference of the International-Society-of-Development-Biologists, SCOTLAND, Edinburgh, 06 September 2009 - 10 September 2009, http://dx.doi.org/10.1016/j.mod.2009.06.384

 Sydney Catalyst Pilot & Seed Funding Award, 2019, Sydney, Australia

Hunter Cell Biology F1000prime Poster Prize, 2019, Lovedale, Australia

Australian BioResources 10th Anniversary Competition Major Prize, 2018, Moss Vale, Australia

Cold Spring Harbor Laboratories Travel Stipend, 2017, Cold Spring Harbor Laboratories, New York, USA.

Young Garvan Award Finalist, 2016, Sydney, Australia.

Traveling grant from the CDB Riken Center, Japan, to attend the symposium “Frontiers in Organogenesis”, 2010, Kobe, Japan.

PhD Fellowship: GRK1104 “From Cells to Organs: Molecular Mechanisms of Organogenesis“, 2008-2010, Freiburg, Germany.

Alumni-Diploma Award, University of Freiburg, Faculty of Biology, 2008, Freiburg, Germany.

My Research Supervision

4 PhD students