Dr David Samuel Khoury
Lecturer

Dr David Samuel Khoury

PhD, UNSW Sydney (2016)

B Science (Advanced Mathematics) (2009)

medicine-health
The Kirby Institute

I am an interdisciplinary researcher, with a background in applied mathematics. I completed my PhD in modelling infection and immunity in malaria in 2016. My research interests continue to be in infectious diseases of the developing world, with a special focus on malaria infection, treatment and immunity, and more recently COVID-19. I lead the Malaria Analytics Group at the Kirby Institute, and I hold an Early Career Research Fellow with the National Health and Medical Research Council (NHMRC). My research involves broad collaboration with experimental biologists, immunologists, and clinicians, both in Australia and internationally.

Phone
+61 2 9385 0980
Location
Kirby Institute, L6 Wallace Wurth Building UNSW Sydney

Publications

  • Journal articles | 2021
    Dr David Samuel Khoury
    Khoury DS; Cromer D; Reynaldi A; Schlub TE; Wheatley AK; Juno JA; Subbarao K; Kent SJ; Triccas JA; Davenport MP, 2021, 'Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection', Nature Medicine, http://dx.doi.org/10.1038/s41591-021-01377-8
    Journal articles | 2021
    Dr David Samuel Khoury
    Wheatley AK; Juno JA; Wang JJ; Selva KJ; Reynaldi A; Tan HX; Lee WS; Wragg KM; Kelly HG; Esterbauer R; Davis SK; Kent HE; Mordant FL; Schlub TE; Gordon DL; Khoury DS; Subbarao K; Cromer D; Gordon TP; Chung AW; Davenport MP; Kent SJ, 2021, 'Evolution of immune responses to SARS-CoV-2 in mild-moderate COVID-19', Nature Communications, vol. 12, pp. 1162, http://dx.doi.org/10.1038/s41467-021-21444-5
    Journal articles | 2021
    Dr David Samuel Khoury
    Rebelo M; Pawliw R; Gower J; Webb L; Mitchell H; Pava Z; Watts RE; Davenport MP; McCarthy JS; Khoury DS, 2021, 'Parasite Viability as a Superior Measure of Antimalarial Drug Activity in Humans', The Journal of infectious diseases, vol. 223, pp. 2154 - 2163, http://dx.doi.org/10.1093/infdis/jiaa678
    Journal articles | 2021
    Dr David Samuel Khoury
    Cromer D; Juno JA; Khoury D; Reynaldi A; Wheatley AK; Kent SJ; Davenport MP, 2021, 'Prospects for durable immune control of SARS-CoV-2 and prevention of reinfection', Nature Reviews Immunology, vol. 21, pp. 395 - 404, http://dx.doi.org/10.1038/s41577-021-00550-x
    Journal articles | 2021
    Dr David Samuel Khoury
    Cromer D; Reynaldi A; Steain M; Triccas J; Davenport M; Khoury D, 2021, 'Relating in vitro neutralisation level and protection in the CVnCoV (CUREVAC) trial', , http://dx.doi.org/10.1101/2021.06.29.21259504
    Journal articles | 2021
    Dr David Samuel Khoury
    Khoury D; Cromer D; Reynaldi A; Schlub T; Wheatley A; Juno J; Subbarao K; Kent S; Triccas J; Davenport M, 2021, 'What level of neutralising antibody protects from COVID-19?', , http://dx.doi.org/10.1101/2021.03.09.21252641
    Journal articles | 2020
    Dr David Samuel Khoury
    Corder RM; de Lima ACP; Khoury DS; Docken SS; Davenport MP; Ferreira MU, 2020, 'Quantifying and preventing plasmodium vivax recurrences in primaquine-untreated pregnant women: An observational and modeling study in Brazil', PLoS Neglected Tropical Diseases, vol. 14, pp. 1 - 16, http://dx.doi.org/10.1371/journal.pntd.0008526
    Journal articles | 2020
    Dr David Samuel Khoury
    Soon MSF; Lee HJ; Engel JA; Straube J; Thomas BS; Pernold CPS; Clarke LS; Laohamonthonkul P; Haldar RN; Williams CG; Lansink LIM; Moreira ML; Bramhall M; Koufariotis LT; Wood S; Chen X; James KR; Lönnberg T; Lane SW; Belz GT; Engwerda CR; Khoury DS; Davenport MP; Svensson V; Teichmann SA; Haque A, 2020, 'Transcriptome dynamics of CD4+ T cells during malaria maps gradual transit from effector to memory', Nature Immunology, vol. 21, pp. 1597 - 1610, http://dx.doi.org/10.1038/s41590-020-0800-8
    Journal articles | 2020
    Dr David Samuel Khoury
    Khoury DS; Cao P; Zaloumis SG; Davenport MP, 2020, 'Artemisinin Resistance and the Unique Selection Pressure of a Short-acting Antimalarial', Trends in Parasitology, vol. 36, pp. 884 - 887, http://dx.doi.org/10.1016/j.pt.2020.07.004
    Journal articles | 2020
    Dr David Samuel Khoury
    Khoury DS; Wheatley AK; Ramuta MD; Reynaldi A; Cromer D; Subbarao K; O’Connor DH; Kent SJ; Davenport MP, 2020, 'Measuring immunity to SARS-CoV-2 infection: comparing assays and animal models', Nature Reviews Immunology, vol. 20, pp. 727 - 738, http://dx.doi.org/10.1038/s41577-020-00471-1
    Journal articles | 2020
    Dr David Samuel Khoury
    Collins KA; Wang CYT; Adams M; Mitchell H; Robinson GJ; Rampton M; Elliott S; Odedra A; Khoury D; Ballard E; Shelper TB; Lucantoni L; Avery VM; Chalon S; Moehrle JJ; McCarthy JS, 2020, 'A Plasmodium vivax experimental human infection model for evaluating efficacy of interventions', Journal of Clinical Investigation, vol. 130, pp. 2920 - 2927, http://dx.doi.org/10.1172/JCI134923
    Journal articles | 2020
    Dr David Samuel Khoury
    Khoury DS; Zaloumis SG; Grigg MJ; Haque A; Davenport MP, 2020, 'Malaria Parasite Clearance: What Are We Really Measuring?', Trends in Parasitology, vol. 36, pp. 413 - 426, http://dx.doi.org/10.1016/j.pt.2020.02.005
    Journal articles | 2020
    Dr David Samuel Khoury
    Rebelo M; McCarthy JS; Khoury DS, 2020, 'Response to White and Watson.', J Infect Dis, http://dx.doi.org/10.1093/infdis/jiaa791
    Journal articles | 2019
    Dr David Samuel Khoury
    Akter J; Khoury DS; Aogo R; Lansink LIM; SheelaNair A; Thomas BS; Laohamonthonkul P; Pernold CPS; Dixon MWA; Soon MSF; Fogg LG; Engel JA; Elliott T; Sebina I; James KR; Cromer D; Davenport MP; Haque A, 2019, 'Plasmodium-specific antibodies block in vivo parasite growth without clearing infected red blood cells', PLoS Pathogens, vol. 15, pp. e1007599, http://dx.doi.org/10.1371/journal.ppat.1007599
    Journal articles | 2019
    Dr David Samuel Khoury
    Davenport MP; Khoury DS; Cromer D; Lewin SR; Kelleher AD; Kent SJ, 2019, 'Functional cure of HIV: the scale of the challenge', Nature Reviews Immunology, vol. 19, pp. 45 - 54, http://dx.doi.org/10.1038/s41577-018-0085-4
    Journal articles | 2019
    Dr David Samuel Khoury
    Khoury DS; Cromer D; Möhrle JJ; McCarthy JS; Davenport MP, 2019, 'Corrigendum: Defining the effectiveness of antimalarial chemotherapy: Investigation of the lag in parasite clearance following drug administration (Journal of Infectious Diseases (2016) 214 (753-761) DOI: 10.1093/infdis/jiw234)', Journal of Infectious Diseases, vol. 219, pp. 1852 - 1853, http://dx.doi.org/10.1093/infdis/jiy729
    Journal articles | 2019
    Dr David Samuel Khoury
    Betts M; Kuri Cervantes L; Pampena MB; Samer S; Khoury D; Frank I; Paiardini M; Davenport M; Bar K; Veazey R, 2019, 'Peripheral blood SIV/HIV originates from infected cells in tissues', Journal of Virus Eradication, vol. 5, pp. 27 - 27, http://dx.doi.org/10.1016/s2055-6640(20)30142-4
    Journal articles | 2018
    Dr David Samuel Khoury
    Zaloumis SG; Cao P; Dini S; Davenport MP; Cromer D; Khoury DS; Fowkes FJI; McCaw JM; Simpson JA, 2018, 'In silico investigation of the decline in clinical efficacy of artemisinin combination therapies due to increasing artemisinin and partner drug resistance', Antimicrobial Agents and Chemotherapy, vol. 62, http://dx.doi.org/10.1128/AAC.01292-18
    Journal articles | 2018
    Dr David Samuel Khoury
    Aogo RA; Khoury DS; Cromer D; Elliott T; Akter J; Fogg LG; Nair AS; Liligeto UN; Soon MSF; Thomas BS; Pernold CPS; Romanczuk AS; Laohamonthonkul P; Haque A; Davenport MP, 2018, 'Quantification of host-mediated parasite clearance during blood-stage Plasmodium infection and anti-malarial drug treatment in mice', International Journal for Parasitology, vol. 48, pp. 903 - 913, http://dx.doi.org/10.1016/j.ijpara.2018.05.010
    Journal articles | 2018
    Dr David Samuel Khoury
    Khoury DS; Aogo R; Randriafanomezantsoa-Radohery G; McCaw JM; Simpson JA; McCarthy JS; Haque A; Cromer D; Davenport MP, 2018, 'Within-host modeling of blood-stage malaria', Immunological Reviews, vol. 285, pp. 168 - 193, http://dx.doi.org/10.1111/imr.12697
    Journal articles | 2017
    Dr David Samuel Khoury
    Khoury DS; Cromer D; Elliott T; Soon MSF; Thomas BS; James KR; Best SE; Aogo RA; Engel JA; Gartlan KH; Akter J; Sebina I; Haque A; Davenport MP, 2017, 'Characterising the effect of antimalarial drugs on the maturation and clearance of murine blood-stage Plasmodium parasites in vivo', International Journal for Parasitology, vol. 47, pp. 913 - 922, http://dx.doi.org/10.1016/j.ijpara.2017.05.009
    Journal articles | 2017
    Dr David Samuel Khoury
    Khoury DS; Cromer D; Akter J; Sebina I; Elliott T; Thomas BS; Soon MSF; James KR; Best SE; Haque A; Davenport MP, 2017, 'Host-mediated impairment of parasite maturation during blood-stage Plasmodium infection', Proceedings of the National Academy of Sciences of the United States of America, vol. 114, pp. 7701 - 7706, http://dx.doi.org/10.1073/pnas.1618939114
    Journal articles | 2017
    Dr David Samuel Khoury
    Cao P; Klonis N; Zaloumis S; Khoury DS; Cromer D; Davenport MP; Tilley L; Simpson JA; McCaw JM, 2017, 'A mechanistic model quantifies artemisinin-induced parasite growth retardation in blood-stage Plasmodium falciparum infection', Journal of Theoretical Biology, vol. 430, pp. 117 - 127, http://dx.doi.org/10.1016/j.jtbi.2017.07.017
    Journal articles | 2016
    Dr David Samuel Khoury
    Khoury DS; Cromer D; Möhrle JJ; McCarthy JS; Davenport MP, 2016, 'Defining the effectiveness of antimalarial chemotherapy: Investigation of the lag in parasite clearance following drug administration', Journal of Infectious Diseases, vol. 214, pp. 753 - 761, http://dx.doi.org/10.1093/infdis/jiw234
    Journal articles | 2016
    Dr David Samuel Khoury
    Griffin P; Pasay C; Elliott S; Sekuloski S; Sikulu M; Hugo L; Khoury D; Cromer D; Davenport M; Sattabongkot J; Ivinson K; Ockenhouse C; McCarthy J, 2016, 'Safety and Reproducibility of a Clinical Trial System Using Induced Blood Stage Plasmodium vivax Infection and Its Potential as a Model to Evaluate Malaria Transmission', PLoS Neglected Tropical Diseases, vol. 10, http://dx.doi.org/10.1371/journal.pntd.0005139
    Journal articles | 2015
    Dr David Samuel Khoury
    Khoury DS; Cromer D; Best SE; James KR; Sebina I; Haque A; Davenport MP, 2015, 'Reduced erythrocyte susceptibility and increased host clearance of young parasites slows Plasmodium growth in a murine model of severe malaria', Scientific Reports, vol. 5, http://dx.doi.org/10.1038/srep09412
    Journal articles | 2013
    Dr David Samuel Khoury
    Khoury DS; Barron AB; Myerscough MR, 2013, 'Modelling Food and Population Dynamics in Honey Bee Colonies', PLoS ONE, vol. 8, pp. Article numbere59084, http://dx.doi.org/10.1371/journal.pone.0059084
    Journal articles | 2013
    Dr David Samuel Khoury
    Khoury DS; Cromer D; Best SE; James KR; Kim PS; Engwerda CR; Haque A; Davenport MP, 2013, 'Effect of mature, blood-stage Plasmodium parasite sequestration on pathogen biomass in mathematical and in vivo models of malaria.', Infection and Immunity, vol. 82, pp. 212 - 220, http://dx.doi.org/10.1128/IAI.00705-13
    Journal articles | 2013
    Dr David Samuel Khoury
    Delaney GW; Khoury D, 2013, 'Onset of rigidity in 3D stretched string networks', European Physical Journal B, vol. 86, http://dx.doi.org/10.1140/epjb/e2012-30445-y
    Journal articles | 2011
    Dr David Samuel Khoury
    Khoury DS; Myerscough MR; Barron AB, 2011, 'A quantitative model of honey bee colony population dynamics', PLoS ONE, vol. 6, http://dx.doi.org/10.1371/journal.pone.0018491
  • Conference Papers | 2015
    Dr David Samuel Khoury
    Myerscough MR; Khoury DS; Ronzani S; Barron AB, 2015, 'Why Do Hives Die? Using Mathematics to Solve the Problem of Honey Bee Colony Collapse', in Anderssen B; Broadbridge P; Fukumoto Y; Kamiyama N; Mizoguchi Y; Polthier K; Saeki O (eds.), ROLE AND IMPORTANCE OF MATHEMATICS IN INNOVATION, SPRINGER-VERLAG SINGAPORE PTE LTD, Kyushu Univ, Ito Campus, Inst Math Ind, Fukuoka, JAPAN, pp. 35 - 50, presented at Forum on Math-for-Industry - Role and Importance of Mathematics in Innovation, Kyushu Univ, Ito Campus, Inst Math Ind, Fukuoka, JAPAN, 26 October 2015 - 30 October 2015, http://dx.doi.org/10.1007/978-981-10-0962-4_4

Awards

Grants

Early Career Fellowship, NHMRC (commenced 2018)

Discovery Project, ARC (commenced 2018)

Media