Dr David Khoury

Senior Research Fellow

PhD, UNSW Sydney (2016)

B Science (Advanced Mathematics) (2009)

Medicine & Health

The Kirby Institute

I am an interdisciplinary researcher, with a background in applied mathematics. I completed my PhD in modelling infection and immunity in malaria in 2016. My research interests continue to be in infectious diseases of the developing world, with a special focus on malaria infection, treatment and immunity, and more recently COVID-19. I lead the Malaria Analytics Group at the Kirby Institute, and I hold an Early Career Research Fellow with the National Health and Medical Research Council (NHMRC). My research involves broad collaboration with experimental biologists, immunologists, and clinicians, both in Australia and internationally.

Phone

+61 2 9385 0980

E-mail

dkhoury@kirby.unsw.edu.au

Location

Kirby Institute, L6 Wallace Wurth Building UNSW Sydney

Journal articles | 2023

Cromer D; Steain M; Reynaldi A; Schlub TE; Khan SR; Sasson SC; Kent SJ; Khoury DS; Davenport MP, 2023, 'Predicting vaccine effectiveness against severe COVID-19 over time and against variants: a meta-analysis', Nature Communications, 14, http://dx.doi.org/10.1038/s41467-023-37176-7

Journal articles | 2023

Hogan AB; Doohan P; Wu SL; Mesa DO; Toor J; Watson OJ; Winskill P; Charles G; Barnsley G; Riley EM; Khoury DS; Ferguson NM; Ghani AC, 2023, 'Estimating long-term vaccine effectiveness against SARS-CoV-2 variants: a model-based approach', Nature Communications, 14, http://dx.doi.org/10.1038/s41467-023-39736-3

Journal articles | 2023

Hogan AB; Wu SL; Toor J; Mesa DO; Doohan P; Watson OJ; Winskill P; Charles G; Barnsley G; Riley EM; Khoury DS; Ferguson NM; Ghani AC, 2023, 'Long-term vaccination strategies to mitigate the impact of SARS-CoV-2 transmission: A modelling study', PLoS Medicine, 20, http://dx.doi.org/10.1371/journal.pmed.1004195

Journal articles | 2023

Khoury DS; Docken SS; Subbarao K; Kent SJ; Davenport MP; Cromer D, 2023, 'Predicting the efficacy of variant-modified COVID-19 vaccine boosters', Nature Medicine, 29, pp. 574 - 578, http://dx.doi.org/10.1038/s41591-023-02228-4

Journal articles | 2023

Khoury DS; Schlub TE; Cromer D; Steain M; Fong Y; Gilbert PB; Subbarao K; Triccas JA; Kent SJ; Davenport MP, 2023, 'Correlates of Protection, Thresholds of Protection, and Immunobridging among Persons with SARS-CoV-2 Infection', Emerging Infectious Diseases, 29, pp. 381 - 388, http://dx.doi.org/10.3201/eid2902.221422

Journal articles | 2023

Koutsakos M; Reynaldi A; Lee WS; Nguyen J; Amarasena T; Taiaroa G; Kinsella P; Liew KC; Tran T; Kent HE; Tan HX; Rowntree LC; Nguyen THO; Thomas PG; Kedzierska K; Petersen J; Rossjohn J; Williamson DA; Khoury D; Davenport MP; Kent SJ; Wheatley AK; Juno JA, 2023, 'SARS-CoV-2 breakthrough infection induces rapid memory and de novo T cell responses', Immunity, 56, pp. 879 - 892.e4, http://dx.doi.org/10.1016/j.immuni.2023.02.017

Journal articles | 2023

Lansink LIM; Skinner OP; Engel JA; Lee HJ; Soon MSF; Williams CG; SheelaNair A; Pernold CPS; Laohamonthonkul P; Akter J; Stoll T; Hill MM; Talman AM; Russell A; Lawniczak M; Jia X; Chua B; Anderson D; Creek DJ; Davenport MP; Khoury DS; Haque A, 2023, 'Systemic host inflammation induces stage-specific transcriptomic modification and slower maturation in malaria parasites', mBio, 14, pp. e0112923, http://dx.doi.org/10.1128/mbio.01129-23

Journal articles | 2023

Lee WS; Tan HX; Reynaldi A; Esterbauer R; Koutsakos M; Nguyen J; Amarasena T; Kent HE; Aggarwal A; Turville SG; Taiaroa G; Kinsella P; Liew KC; Tran T; Williamson DA; Cromer D; Davenport MP; Kent SJ; Juno JA; Khoury DS; Wheatley AK, 2023, 'Durable reprogramming of neutralizing antibody responses following Omicron breakthrough infection', Science Advances, 9, http://dx.doi.org/10.1126/sciadv.adg5301

Journal articles | 2023

Parkyn Schneider M; Looker O; Rebelo M; Khoury DS; Dixon MWA; Oeuvray C; Crabb BS; McCarthy J; Gilson PR, 2023, 'The delayed bloodstream clearance of Plasmodium falciparum parasites after M5717 treatment is attributable to the inability to modify their red blood cell hosts', Frontiers in Cellular and Infection Microbiology, 13, http://dx.doi.org/10.3389/fcimb.2023.1211613

Journal articles | 2023

Stadler E; Burgess MT; Schlub TE; Khan SR; Chai KL; McQuilten ZK; Wood EM; Polizzotto MN; Kent SJ; Cromer D; Davenport MP; Khoury DS, 2023, 'Monoclonal antibody levels and protection from COVID-19', Nature Communications, 14, http://dx.doi.org/10.1038/s41467-023-40204-1

Journal articles | 2023

Stadler E; Chai KL; Schlub TE; Cromer D; Khan SR; Polizzotto MN; Kent SJ; Beecher C; White H; Turner T; Skoetz N; Estcourt L; McQuilten ZK; Wood EM; Khoury DS; Davenport MP, 2023, 'Determinants of passive antibody efficacy in SARS-CoV-2 infection: a systematic review and meta-analysis', The Lancet Microbe, 4, pp. e883 - e892, http://dx.doi.org/10.1016/S2666-5247(23)00194-5

Journal articles | 2023

Stadler E; Cromer D; Ogunlade S; Ongoiba A; Doumbo S; Kayentao K; Traore B; Crompton PD; Portugal S; Davenport MP; Khoury DS, 2023, 'Evidence for exposure dependent carriage of malaria parasites across the dry season: modelling analysis of longitudinal data', Malaria Journal, 22, http://dx.doi.org/10.1186/s12936-023-04461-1

Journal articles | 2023

Stadler E; Maiga M; Friedrich L; Thathy V; Demarta-Gatsi C; Dara A; Sogore F; Striepen J; Oeuvray C; Djimdé AA; Lee MCS; Dembélé L; Fidock DA; Khoury DS; Spangenberg T, 2023, 'Author Correction: Propensity of selecting mutant parasites for the antimalarial drug cabamiquine (Nature Communications, (2023), 14, 1, (5205), 10.1038/s41467-023-40974-8)', Nature Communications, 14, http://dx.doi.org/10.1038/s41467-023-41287-6

Journal articles | 2023

Stadler E; Maiga M; Friedrich L; Thathy V; Demarta-Gatsi C; Dara A; Sogore F; Striepen J; Oeuvray C; Djimdé AA; Lee MCS; Dembélé L; Fidock DA; Khoury DS; Spangenberg T, 2023, 'Propensity of selecting mutant parasites for the antimalarial drug cabamiquine', Nature Communications, 14, http://dx.doi.org/10.1038/s41467-023-40974-8

Journal articles | 2023

Zhang W; Kedzierski L; Chua BY; Mayo M; Lonzi C; Rigas V; Middleton BF; McQuilten HA; Rowntree LC; Allen LF; Purcell RA; Tan HX; Petersen J; Chaurasia P; Mordant F; Pogorelyy MV; Minervina AA; Crawford JC; Perkins GB; Zhang E; Gras S; Clemens EB; Juno JA; Audsley J; Khoury DS; Holmes NE; Thevarajan I; Subbarao K; Krammer F; Cheng AC; Davenport MP; Grubor-Bauk B; Coates PT; Christensen B; Thomas PG; Wheatley AK; Kent SJ; Rossjohn J; Chung AW; Boffa J; Miller A; Lynar S; Nelson J; Nguyen THO; Davies J; Kedzierska K, 2023, 'Robust and prototypical immune responses toward COVID-19 vaccine in First Nations peoples are impacted by comorbidities', Nature Immunology, 24, pp. 966 - 978, http://dx.doi.org/10.1038/s41590-023-01508-y

Journal articles | 2022

Aggarwal A; Stella AO; Walker G; Akerman A; Esneau C; Milogiannakis V; Burnett DL; McAllery S; Silva MR; Lu Y; Foster CSP; Brilot F; Pillay A; Van Hal S; Mathivanan V; Fichter C; Kindinger A; Hoppe AC; Munier ML; Amatayakul-Chantler S; Roth N; Coppola G; Symonds GP; Schofield P; Jackson J; Lenthall H; Henry JY; Mazigi O; Jäck HM; Davenport MP; Darley DR; Matthews GV; Khoury DS; Cromer D; Goodnow CC; Christ D; Robosa R; Starck DJ; Bartlett NW; Rawlinson WD; Kelleher AD; Turville SG, 2022, 'Platform for isolation and characterization of SARS-CoV-2 variants enables rapid characterization of Omicron in Australia', Nature Microbiology, 7, pp. 896 - 908, http://dx.doi.org/10.1038/s41564-022-01135-7

Journal articles | 2022

Cele S; Jackson L; Khoury DS; Khan K; Moyo-Gwete T; Tegally H; San JE; Cromer D; Scheepers C; Amoako DG; Karim F; Bernstein M; Lustig G; Archary D; Smith M; Ganga Y; Jule Z; Reedoy K; Hwa SH; Giandhari J; Blackburn JM; Gosnell BI; Abdool Karim SS; Hanekom W; Davies MA; Hsiao M; Martin D; Mlisana K; Wibmer CK; Williamson C; York D; Harrichandparsad R; Herbst K; Jeena P; Khoza T; Kløverpris H; Leslie A; Madansein R; Magula N; Manickchund N; Marakalala M; Mazibuko M; Moshabela M; Mthabela N; Naidoo K; Ndhlovu Z; Ndung’u T; Ngcobo N; Nyamande K; Patel V; Smit T; Steyn A; Wong E; von Gottberg A; Bhiman JN; Lessells RJ; Moosa MYS; Davenport MP; de Oliveira T; Moore PL; Sigal A, 2022, 'Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization', Nature, 602, pp. 654 - 656, http://dx.doi.org/10.1038/s41586-021-04387-1

Journal articles | 2022

Cromer D; Reynaldi A; Steain M; Triccas JA; Davenport MP; Khoury DS, 2022, 'Relating in Vitro Neutralization Level and Protection in the CVnCoV (CUREVAC) Trial', Clinical Infectious Diseases, 75, pp. E878 - E879, http://dx.doi.org/10.1093/cid/ciac075

Journal articles | 2022

Cromer D; Steain M; Reynaldi A; Schlub TE; Wheatley AK; Juno JA; Kent SJ; Triccas JA; Khoury DS; Davenport MP, 2022, 'Neutralising antibody titres as predictors of protection against SARS-CoV-2 variants and the impact of boosting: a meta-analysis', The Lancet Microbe, 3, pp. e52 - e61, http://dx.doi.org/10.1016/S2666-5247(21)00267-6

Journal articles | 2022

Goel RR; Painter MM; Lundgreen KA; Apostolidis SA; Baxter AE; Giles JR; Mathew D; Pattekar A; Reynaldi A; Khoury DS; Gouma S; Hicks P; Dysinger S; Hicks A; Sharma H; Herring S; Korte S; KC W; Oldridge DA; Erickson RI; Weirick ME; McAllister CM; Awofolaju M; Tanenbaum N; Dougherty J; Long S; D'Andrea K; Hamilton JT; McLaughlin M; Williams JC; Adamski S; Kuthuru O; Drapeau EM; Davenport MP; Hensley SE; Bates P; Greenplate AR; Wherry EJ, 2022, 'Efficient recall of Omicron-reactive B cell memory after a third dose of SARS-CoV-2 mRNA vaccine', Cell, 185, pp. 1875 - 1887.e8, http://dx.doi.org/10.1016/j.cell.2022.04.009

Journal articles | 2022

Kent SJ; Khoury DS; Reynaldi A; Juno JA; Wheatley AK; Stadler E; John Wherry E; Triccas J; Sasson SC; Cromer D; Davenport MP, 2022, 'Disentangling the relative importance of T cell responses in COVID-19: leading actors or supporting cast?', Nature Reviews Immunology, 22, pp. 387 - 397, http://dx.doi.org/10.1038/s41577-022-00716-1

Journal articles | 2022

Koutsakos M; Lee WS; Reynaldi A; Tan HX; Gare G; Kinsella P; Liew KC; Taiaroa G; Williamson DA; Kent HE; Stadler E; Cromer D; Khoury DS; Wheatley AK; Juno JA; Davenport MP; Kent SJ, 2022, 'The magnitude and timing of recalled immunity after breakthrough infection is shaped by SARS-CoV-2 variants', Immunity, 55, pp. 1316 - 1326.e4, http://dx.doi.org/10.1016/j.immuni.2022.05.018

Journal articles | 2022

Mehra S; Stadler E; Khoury D; McCaw JM; Flegg JA, 2022, 'Hypnozoite dynamics for Plasmodium vivax malaria: The epidemiological effects of radical cure', Journal of Theoretical Biology, 537, http://dx.doi.org/10.1016/j.jtbi.2022.111014

Journal articles | 2022

Radohery GFR; Gower J; Barber BE; Kansagra K; Möhrle JJ; Davenport MP; McCarthy JS; Khoury DS; Rebelo M, 2022, 'Effect of novel antimalarial ZY-19489 on Plasmodium falciparum viability in a volunteer infection study', The Lancet Infectious Diseases, 22, pp. 760 - 761, http://dx.doi.org/10.1016/S1473-3099(22)00294-8

Journal articles | 2022

Radohery GFR; Walz A; Gumpp C; Cherkaoui-Rbati MH; Gobeau N; Gower J; Davenport MP; Rottmann M; McCarthy JS; Möhrle JJ; Rebelo M; Demarta-Gatsi C; Khoury DS, 2022, 'Parasite Viability as a Measure of in Vivo Drug Activity in Preclinical and Early Clinical Antimalarial Drug Assessment', Antimicrobial Agents and Chemotherapy, 66, http://dx.doi.org/10.1128/aac.00114-22

Journal articles | 2022

SheelaNair A; Romanczuk AS; Aogo RA; Haldar RN; Lansink LIM; Cromer D; Salinas YG; Guy RK; McCarthy JS; Davenport MP; Haque A; Khoury DS, 2022, 'Similarly efficacious anti-malarial drugs SJ733 and pyronaridine differ in their ability to remove circulating parasites in mice', Malaria Journal, 21, http://dx.doi.org/10.1186/s12936-022-04075-z

Journal articles | 2022

Stadler E; Cromer D; Mehra S; Adekunle AI; Flegg JA; Anstey NM; Watson JA; Chu CS; Mueller I; Robinson LJ; Schlub TE; Davenport MP; Khoury DS, 2022, 'Population heterogeneity in Plasmodium vivax relapse risk', PLoS Neglected Tropical Diseases, 16, http://dx.doi.org/10.1371/journal.pntd.0010990

Journal articles | 2022

2022, 'Efficient recall of Omicron-reactive B cell memory after a third dose of SARS-CoV-2 mRNA vaccine.', bioRxiv, http://dx.doi.org/10.1101/2022.02.20.481163

Journal articles | 2021

Cromer D; Juno JA; Khoury D; Reynaldi A; Wheatley AK; Kent SJ; Davenport MP, 2021, 'Prospects for durable immune control of SARS-CoV-2 and prevention of reinfection', Nature Reviews Immunology, 21, pp. 395 - 404, http://dx.doi.org/10.1038/s41577-021-00550-x

Journal articles | 2021

Cromer D; Reynaldi A; Steain M; Triccas J; Davenport M; Khoury D, 2021, 'Relating in vitro neutralisation level and protection in the CVnCoV (CUREVAC) trial', , http://dx.doi.org/10.1101/2021.06.29.21259504

Journal articles | 2021

Cromer D; Steain M; Reynaldi A; Schlub T; Wheatley A; Juno J; Kent S; Triccas J; Khoury D; Davenport M, 2021, 'SARS-CoV-2 variants: levels of neutralisation required for protective immunity', , http://dx.doi.org/10.1101/2021.08.11.21261876

Journal articles | 2021

Goel RR; Painter MM; Apostolidis SA; Mathew D; Meng W; Rosenfeld AM; Lundgreen KA; Reynaldi A; Khoury DS; Pattekar A; Gouma S; Kuri-Cervantes L; Hicks P; Dysinger S; Hicks A; Sharma H; Herring S; Korte S; Baxter AE; Oldridge DA; Giles JR; Weirick ME; McAllister CM; Awofolaju M; Tanenbaum N; Drapeau EM; Dougherty J; Long S; D’Andrea K; Hamilton JT; McLaughlin M; Williams JC; Adamski S; Kuthuru O; Frank I; Betts MR; Vella LA; Grifoni A; Weiskopf D; Sette A; Hensley SE; Davenport MP; Bates P; Luning Prak ET; Greenplate AR; John Wherry E, 2021, 'mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern', Science, 374, http://dx.doi.org/10.1126/science.abm0829

Journal articles | 2021

Khoury D; Cromer D; Reynaldi A; Schlub T; Wheatley A; Juno J; Subbarao K; Kent S; Triccas J; Davenport M, 2021, 'What level of neutralising antibody protects from COVID-19?', , http://dx.doi.org/10.1101/2021.03.09.21252641

Journal articles | 2021

Khoury DS; Cromer D; Reynaldi A; Schlub TE; Wheatley AK; Juno JA; Subbarao K; Kent SJ; Triccas JA; Davenport MP, 2021, 'Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection', Nature Medicine, 27, pp. 1205 - 1211, http://dx.doi.org/10.1038/s41591-021-01377-8

Journal articles | 2021

Rebelo M; McCarthy JS; Khoury DS, 2021, 'Reply to White and Watson', Journal of Infectious Diseases, 224, pp. 739 - 740, http://dx.doi.org/10.1093/infdis/jiaa791

Journal articles | 2021

Rebelo M; McCarthy JS; Khoury DS, 2021, 'Reply to White and Watson.', J Infect Dis, 224, pp. 739 - 740, http://dx.doi.org/10.1093/infdis/jiaa791

Journal articles | 2021

Rebelo M; Pawliw R; Gower J; Webb L; Mitchell H; Pava Z; Watts RE; Davenport MP; McCarthy JS; Khoury DS, 2021, 'Parasite Viability as a Superior Measure of Antimalarial Drug Activity in Humans', Journal of Infectious Diseases, 223, pp. 2154 - 2163, http://dx.doi.org/10.1093/infdis/jiaa678

Journal articles | 2021

Wheatley AK; Juno JA; Wang JJ; Selva KJ; Reynaldi A; Tan HX; Lee WS; Wragg KM; Kelly HG; Esterbauer R; Davis SK; Kent HE; Mordant FL; Schlub TE; Gordon DL; Khoury DS; Subbarao K; Cromer D; Gordon TP; Chung AW; Davenport MP; Kent SJ, 2021, 'Evolution of immune responses to SARS-CoV-2 in mild-moderate COVID-19', Nature Communications, 12, http://dx.doi.org/10.1038/s41467-021-21444-5

Journal articles | 2020

Collins KA; Wang CYT; Adams M; Mitchell H; Robinson GJ; Rampton M; Elliott S; Odedra A; Khoury D; Ballard E; Shelper TB; Lucantoni L; Avery VM; Chalon S; Moehrle JJ; McCarthy JS, 2020, 'A Plasmodium vivax experimental human infection model for evaluating efficacy of interventions', Journal of Clinical Investigation, 130, pp. 2920 - 2927, http://dx.doi.org/10.1172/JCI134923

Journal articles | 2020

Corder RM; de Lima ACP; Khoury DS; Docken SS; Davenport MP; Ferreira MU, 2020, 'Quantifying and preventing plasmodium vivax recurrences in primaquine-untreated pregnant women: An observational and modeling study in Brazil', PLoS Neglected Tropical Diseases, 14, pp. 1 - 16, http://dx.doi.org/10.1371/journal.pntd.0008526

Journal articles | 2020

Khoury DS; Cao P; Zaloumis SG; Davenport MP, 2020, 'Artemisinin Resistance and the Unique Selection Pressure of a Short-acting Antimalarial', Trends in Parasitology, 36, pp. 884 - 887, http://dx.doi.org/10.1016/j.pt.2020.07.004

Journal articles | 2020

Khoury DS; Wheatley AK; Ramuta MD; Reynaldi A; Cromer D; Subbarao K; O’Connor DH; Kent SJ; Davenport MP, 2020, 'Measuring immunity to SARS-CoV-2 infection: comparing assays and animal models', Nature Reviews Immunology, 20, pp. 727 - 738, http://dx.doi.org/10.1038/s41577-020-00471-1

Journal articles | 2020

Khoury DS; Zaloumis SG; Grigg MJ; Haque A; Davenport MP; Cromer D; Rebelo M; Cao P; McCaw JM; Simpson JA; Flegg JA; Wilson DW; Anstey NM; McCarthy JS, 2020, 'Malaria Parasite Clearance: What Are We Really Measuring?', Trends in Parasitology, 36, pp. 413 - 426, http://dx.doi.org/10.1016/j.pt.2020.02.005

Journal articles | 2020

Soon MSF; Lee HJ; Engel JA; Straube J; Thomas BS; Pernold CPS; Clarke LS; Laohamonthonkul P; Haldar RN; Williams CG; Lansink LIM; Moreira ML; Bramhall M; Koufariotis LT; Wood S; Chen X; James KR; Lönnberg T; Lane SW; Belz GT; Engwerda CR; Khoury DS; Davenport MP; Svensson V; Teichmann SA; Haque A, 2020, 'Transcriptome dynamics of CD4⁺ T cells during malaria maps gradual transit from effector to memory', Nature Immunology, 21, pp. 1597 - 1610, http://dx.doi.org/10.1038/s41590-020-0800-8

Journal articles | 2019

Akter J; Khoury DS; Aogo R; Lansink LIM; SheelaNair A; Thomas BS; Laohamonthonkul P; Pernold CPS; Dixon MWA; Soon MSF; Fogg LG; Engel JA; Elliott T; Sebina I; James KR; Cromer D; Davenport MP; Haque A, 2019, 'Plasmodium-specific antibodies block in vivo parasite growth without clearing infected red blood cells', PLoS Pathogens, 15, http://dx.doi.org/10.1371/journal.ppat.1007599

Journal articles | 2019

Betts M; Kuri Cervantes L; Pampena MB; Samer S; Khoury D; Frank I; Paiardini M; Davenport M; Bar K; Veazey R, 2019, 'Peripheral blood SIV/HIV originates from infected cells in tissues', Journal of Virus Eradication, 5, pp. 27 - 27, http://dx.doi.org/10.1016/s2055-6640(20)30142-4

Journal articles | 2019

Davenport MP; Khoury DS; Cromer D; Lewin SR; Kelleher AD; Kent SJ, 2019, 'Functional cure of HIV: the scale of the challenge', Nature Reviews Immunology, 19, pp. 45 - 54, http://dx.doi.org/10.1038/s41577-018-0085-4

Journal articles | 2019

Khoury DS; Cromer D; Möhrle JJ; McCarthy JS; Davenport MP, 2019, 'Corrigendum: Defining the effectiveness of antimalarial chemotherapy: Investigation of the lag in parasite clearance following drug administration (Journal of Infectious Diseases (2016) 214 (753-761) DOI: 10.1093/infdis/jiw234)', Journal of Infectious Diseases, 219, pp. 1852 - 1853, http://dx.doi.org/10.1093/infdis/jiy729

Journal articles | 2018

Aogo RA; Khoury DS; Cromer D; Elliott T; Akter J; Fogg LG; Nair AS; Liligeto UN; Soon MSF; Thomas BS; Pernold CPS; Romanczuk AS; Laohamonthonkul P; Haque A; Davenport MP, 2018, 'Quantification of host-mediated parasite clearance during blood-stage Plasmodium infection and anti-malarial drug treatment in mice', International Journal for Parasitology, 48, pp. 903 - 913, http://dx.doi.org/10.1016/j.ijpara.2018.05.010

Journal articles | 2018

Khoury DS; Aogo R; Randriafanomezantsoa-Radohery G; McCaw JM; Simpson JA; McCarthy JS; Haque A; Cromer D; Davenport MP, 2018, 'Within-host modeling of blood-stage malaria', Immunological Reviews, 285, pp. 168 - 193, http://dx.doi.org/10.1111/imr.12697

Journal articles | 2018

Zaloumis SG; Cao P; Dini S; Davenport MP; Cromer D; Khoury DS; Fowkes FJI; McCaw JM; Simpson JA, 2018, 'In silico investigation of the decline in clinical efficacy of artemisinin combination therapies due to increasing artemisinin and partner drug resistance', Antimicrobial Agents and Chemotherapy, 62, http://dx.doi.org/10.1128/AAC.01292-18

Journal articles | 2017

Cao P; Klonis N; Zaloumis S; Khoury DS; Cromer D; Davenport MP; Tilley L; Simpson JA; McCaw JM, 2017, 'A mechanistic model quantifies artemisinin-induced parasite growth retardation in blood-stage Plasmodium falciparum infection', Journal of Theoretical Biology, 430, pp. 117 - 127, http://dx.doi.org/10.1016/j.jtbi.2017.07.017

Journal articles | 2017

Khoury DS; Cromer D; Akter J; Sebina I; Elliott T; Thomas BS; Soon MSF; James KR; Best SE; Haque A; Davenport MP, 2017, 'Host-mediated impairment of parasite maturation during blood-stage Plasmodium infection', Proceedings of the National Academy of Sciences of the United States of America, 114, pp. 7701 - 7706, http://dx.doi.org/10.1073/pnas.1618939114

Journal articles | 2017

Khoury DS; Cromer D; Elliott T; Soon MSF; Thomas BS; James KR; Best SE; Aogo RA; Engel JA; Gartlan KH; Akter J; Sebina I; Haque A; Davenport MP, 2017, 'Characterising the effect of antimalarial drugs on the maturation and clearance of murine blood-stage Plasmodium parasites in vivo', International Journal for Parasitology, 47, pp. 913 - 922, http://dx.doi.org/10.1016/j.ijpara.2017.05.009

Journal articles | 2016

Griffin P; Pasay C; Elliott S; Sekuloski S; Sikulu M; Hugo L; Khoury D; Cromer D; Davenport M; Sattabongkot J; Ivinson K; Ockenhouse C; McCarthy J, 2016, 'Safety and Reproducibility of a Clinical Trial System Using Induced Blood Stage Plasmodium vivax Infection and Its Potential as a Model to Evaluate Malaria Transmission', PLoS Neglected Tropical Diseases, 10, http://dx.doi.org/10.1371/journal.pntd.0005139

Journal articles | 2016

Khoury DS; Cromer D; Möhrle JJ; McCarthy JS; Davenport MP, 2016, 'Defining the effectiveness of antimalarial chemotherapy: Investigation of the lag in parasite clearance following drug administration', Journal of Infectious Diseases, 214, pp. 753 - 761, http://dx.doi.org/10.1093/infdis/jiw234

Journal articles | 2015

Khoury DS; Cromer D; Best SE; James KR; Sebina I; Haque A; Davenport MP, 2015, 'Reduced erythrocyte susceptibility and increased host clearance of young parasites slows Plasmodium growth in a murine model of severe malaria', Scientific Reports, 5, http://dx.doi.org/10.1038/srep09412

Journal articles | 2013

Delaney GW; Khoury D, 2013, 'Onset of rigidity in 3D stretched string networks', European Physical Journal B, 86, http://dx.doi.org/10.1140/epjb/e2012-30445-y

Journal articles | 2013

Khoury DS; Barron AB; Myerscough MR, 2013, 'Modelling Food and Population Dynamics in Honey Bee Colonies', PLoS ONE, 8, pp. Article numbere59084, http://dx.doi.org/10.1371/journal.pone.0059084

Journal articles | 2013

Khoury DS; Cromer D; Best SE; James KR; Kim PS; Engwerda CR; Haque A; Davenport MP, 2013, 'Effect of mature, blood-stage Plasmodium parasite sequestration on pathogen biomass in mathematical and in vivo models of malaria.', Infection and Immunity, http://dx.doi.org/10.1128/IAI.00705-13

Journal articles | 2011

Khoury DS; Myerscough MR; Barron AB, 2011, 'A quantitative model of honey bee colony population dynamics', PLoS ONE, 6, http://dx.doi.org/10.1371/journal.pone.0018491
Working Papers | 2022

Goel RR; Painter MM; Lundgreen KA; Apostolidis SA; Baxter AE; Giles JR; Mathew D; Pattekar A; Reynaldi A; Khoury DS; Gouma S; Hicks P; Dysinger S; Hicks A; Sharma H; Herring S; Korte S; Kc W; Oldridge DA; Erickson RI; Weirick ME; McAllister CM; Awofolaju M; Tanenbaum N; Dougherty J; Long S; D'Andrea K; Hamilton JT; McLaughlin M; Williams JC; Adamski S; Kuthuru O; Drapeau EM; Davenport MP; Hensley SE; Bates P; Greenplate AR; Wherry EJ, 2022, Efficient recall of Omicron-reactive B cell memory after a third dose of SARS-CoV-2 mRNA vaccine., http://dx.doi.org10.1101/2022.02.20.481163, https://www.ncbi.nlm.nih.gov/pubmed/35233575

Working Papers | 2021

Cele S; Jackson L; Khoury DS; Khan K; Moyo-Gwete T; Tegally H; San JE; Cromer D; Scheepers C; Amoako D; Karim F; Bernstein M; Lustig G; Archary D; Smith M; Ganga Y; Jule Z; Reedoy K; Hwa S-H; Giandhari J; Blackburn JM; Gosnell BI; Abdool Karim SS; Hanekom W; NGS-SA ; COMMIT-KZN Team ; von Gottberg A; Bhiman J; Lessells RJ; Moosa M-YS; Davenport MP; de Oliveira T; Moore PL; Sigal A, 2021, SARS-CoV-2 Omicron has extensive but incomplete escape of Pfizer BNT162b2 elicited neutralization and requires ACE2 for infection., http://dx.doi.org10.1101/2021.12.08.21267417, https://www.ncbi.nlm.nih.gov/pubmed/34909788
Preprints | 2023

Berry M; Khan S; Schlub T; Notaras A; Kunasekaran M; Grulich A; MacIntyre R; Davenport M; Khoury D, 2023, Predicting vaccine effectiveness in Mpox, , http://dx.doi.org/10.1101/2023.11.23.23298850

Preprints | 2023

Elias K; Khan S; Stadler E; Schlub T; Cromer D; Polizzotto M; Kent S; Turner T; Davenport M; Khoury D, 2023, Viral clearance as a surrogate of clinical efficacy for COVID-19 therapies in outpatients: A systematic review and meta-analysis, , http://dx.doi.org/10.1101/2023.06.18.23291566

Preprints | 2023

Hogan AB; Doohan P; Wu SL; Mesa DO; Toor J; Watson OJ; Winskill P; Charles G; Barnsley G; Riley EM; Khoury DS; Ferguson NM; Ghani AC, 2023, Estimating long-term vaccine effectiveness against SARS-CoV-2 variants: a model-based approach, , http://dx.doi.org/10.1101/2023.01.03.23284131

Preprints | 2023

Hogan AB; Wu SL; Toor J; Mesa DO; Doohan P; Watson OJ; Winskill P; Charles G; Barnsley G; Riley EM; Khoury DS; Ferguson NM; Ghani AC, 2023, Long term vaccination strategies to mitigate the impact of SARS-CoV-2 transmission: a modelling study, , http://dx.doi.org/10.1101/2023.02.09.23285743

Preprints | 2023

Lee WS; Tan H-X; Reynaldi A; Esterbauer R; Koutsakos M; Nguyen J; Amarasena T; Kent HE; Aggarwal A; Turville SG; Taiaroa G; Kinsella P; Liew KC; Tran T; Williamson DA; Cromer D; Davenport MP; Kent SJ; Juno JA; Khoury DS; Wheatley AK, 2023, Durable reprogramming of neutralising antibody responses following breakthrough Omicron infection, , http://dx.doi.org/10.1101/2023.02.19.23286159

Preprints | 2023

Williams CG; Moreira ML; Asatsuma T; Skinner OP; Lee HJ; Li S; Barrera I; Murray E; Soon MSF; Engel JA; Khoury DS; Asad S; Steiner TM; Joseph R; Alexandre Y; Mueller SN; Chen F; Haque A, 2023, Spatial transcriptomics maps molecular and cellular requirements for CD4⁺T cell-dependent immunity to malaria, , http://dx.doi.org/10.1101/2023.02.23.529309

Preprints | 2022

Cromer D; Steain M; Reynaldi A; Schlub T; Sasson S; Kent S; Khoury D; Davenport MP, 2022, Neutralising antibodies predict protection from severe COVID-19, , http://dx.doi.org/10.1101/2022.06.09.22275942

Preprints | 2022

Hogan AB; Wu SL; Doohan P; Watson OJ; Winskill P; Charles G; Barnsley G; Riley EM; Khoury DS; Ferguson NM; Ghani AC, 2022, The value of vaccine booster doses to mitigate the global impact of the Omicron SARS-CoV-2 variant, , http://dx.doi.org/10.1101/2022.01.17.22269222

Preprints | 2022

Khoury D; Docken S; Subbarao K; Kent S; Davenport M; Cromer D, 2022, Predicting the efficacy of variant-modified COVID-19 vaccine boosters, , http://dx.doi.org/10.1101/2022.08.25.22279237

Preprints | 2022

Khoury D; Schlub T; Cromer D; Steain M; Fong Y; Gilbert P; Subbarao K; Triccas J; Kent S; Davenport M, 2022, Correlates of protection, thresholds of protection, and immunobridging in SARS-CoV-2 infection, , http://dx.doi.org/10.1101/2022.06.05.22275943

Preprints | 2022

Koutsakos M; Reynaldi A; Lee WS; Nguyen J; Amarasena T; Taiaroa G; Kinsella P; Liew KC; Tran T; Kent HE; Tan H-X; Rowntree LC; Nguyen THO; Thomas PG; Kedzierska K; Petersen J; Rossjohn J; Williamson DA; Khoury D; Davenport MP; Kent SJ; Wheatley AK; Juno JA, 2022, Rapid recall andde novoT cell responses during SARS-CoV-2 breakthrough infection, , http://dx.doi.org/10.1101/2022.12.19.521129

Preprints | 2022

Stadler E; Burgess M; Schlub T; Chai KL; McQuilten Z; Wood E; Polizzotto M; Kent S; Cromer D; Davenport M; Khoury D, 2022, Monoclonal antibody levels and protection from COVID-19, , http://dx.doi.org/10.1101/2022.11.22.22282199

Preprints | 2022

Stadler E; Chai KL; Schlub T; Cromer D; Polizzotto M; Kent S; Beecher C; White H; White H; Turner T; Skoetz N; Skoetz N; Estcourt L; McQuilten Z; Wood E; Khoury D; Davenport M, 2022, Determinants of passive antibody efficacy in SARS-CoV-2 infection, , http://dx.doi.org/10.1101/2022.03.21.22272672

Preprints | 2022

Stadler E; Cromer D; Mehra S; Adekunle A; Flegg J; Anstey N; Watson J; Chu C; Mueller I; Robinson L; Schlub T; Davenport M; Khoury D, 2022, Risk of Plasmodium vivax recurrences follows a 30-70 rule and indicates relapse heterogeneity in the population, , http://dx.doi.org/10.1101/2022.05.18.22275180

Preprints | 2022

Stadler E; Cromer D; Ogunlade S; Ongoiba A; Doumbo S; Kayentao K; Traore B; Crompton P; Portugal S; Davenport M; Khoury D, 2022, A role for super-spreaders in carrying malaria parasites across the months-long dry season, , http://dx.doi.org/10.1101/2022.04.28.22274398

Preprints | 2021

Goel RR; Painter MM; Apostolidis SA; Mathew D; Meng W; Rosenfeld AM; Lundgreen KA; Reynaldi A; Khoury DS; Pattekar A; Gouma S; Kuri-Cervantes L; Hicks P; Dysinger S; Hicks A; Sharma H; Herring S; Korte S; Baxter AE; Oldridge DA; Giles JR; Weirick ME; McAllister CM; Awofolaju M; Tanenbaum N; Drapeau EM; Dougherty J; Long S; D'Andrea K; Hamilton JT; McLaughlin M; Williams JC; Adamski S; Kuthuru O; UPenn COVID Processing Unit ; Frank I; Betts MR; Vella LA; Grifoni A; Weiskopf D; Sette A; Hensley SE; Davenport MP; Bates P; Luning Prak ET; Greenplate AR; Wherry EJ, 2021, mRNA Vaccination Induces Durable Immune Memory to SARS-CoV-2 with Continued Evolution to Variants of Concern., , http://dx.doi.org/10.1101/2021.08.23.457229

Preprints | 2021

Khoury D; Steain M; Triccas J; Sigal A; Davenport M; Cromer D, 2021, A meta-analysis of Early Results to predict Vaccine efficacy against Omicron, , http://dx.doi.org/10.1101/2021.12.13.21267748

Preprints | 2021

Koutsakos M; Lee WS; Reynaldi A; Tan H-X; Gare G; Kinsella P; Liew KC; Williamson DA; Kent HE; Stadler E; Cromer D; Khoury DS; Wheatley AK; Juno JA; Davenport MP; Kent SJ, 2021, Dynamics of immune recall following SARS-CoV-2 vaccination or breakthrough infection, , http://dx.doi.org/10.1101/2021.12.23.21268285

Conference Abstracts | 2021

Lansink LIM; Engel JA; Lee HJ; Soon MSF; Williams CG; Aogo RA; Cromer D; Davenport MP; Khoury DS; Haque A, 2021, 'Exposure to host inflammation in vivo induces rapid transcriptomic change and impaired maturation in malaria parasites', in JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 206, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000713665801305&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Preprints | 2021

Lansink LIM; Engel JA; Lee HJ; Soon MSF; Williams CG; SheelaNair A; Pernold CPS; Laohamonthonkul P; Akter J; Stoll T; Hill MM; Talman AM; Russell A; Lawniczak M; Davenport MP; Khoury DS; Haque A, 2021, Systemic host inflammation induces stage-specific transcriptomic modification and slower maturation in malaria parasites, , http://dx.doi.org/10.1101/2021.08.18.456784

Preprints | 2021

Mehra S; Stadler E; Khoury D; McCaw JM; Flegg JA, 2021, Hypnozoite dynamics for Plasmodium vivax malaria: the epidemiological effects of radical cure, , http://dx.doi.org/10.48550/arxiv.2107.00779

Preprints | 2020

Wheatley AK; Juno JA; Wang JJ; Selva KJ; Reynaldi A; Tan H-X; Shi Lee W; Wragg KM; Kelly HG; Esterbauer R; Davis SK; Kent HE; Mordant FL; Schlub TE; Gordon DL; Khoury DS; Subbarao K; Cromer D; Gordon TP; Chung AW; Davenport MP; Kent SJ, 2020, Evolution of immunity to SARS-CoV-2, , http://dx.doi.org/10.1101/2020.09.09.20191205

Preprints | 2019

Soon M; Lee HJ; Engel J; Straube J; Thomas B; Clarke L; Laohamonthonkul P; Pernold C; Haldar R; Williams C; Lansink L; Koufariotis R; Lakis V; Wood S; Chen X; James K; Lönnberg T; Lane S; Davenport M; Khoury D; Svensson V; Teichmann S; Haque A, 2019, Transcriptome Dynamics Reveals Progressive Transition from Effector to Memory in CD4⁺T cells, , http://dx.doi.org/10.1101/675967

Preprints | 2017

Cao P; Klonis N; Zaloumis S; Khoury DS; Cromer D; Davenport MP; Tilley L; Simpson JA; McCaw JM, 2017, A mechanistic model quantifies artemisinin-induced parasite growth retardation in blood-stage Plasmodium falciparum infection, , http://dx.doi.org/10.48550/arxiv.1701.05302

Conference Papers | 2015

Myerscough MR; Khoury DS; Ronzani S; Barron AB, 2015, 'Why Do Hives Die? Using Mathematics to Solve the Problem of Honey Bee Colony Collapse', in Anderssen B; Broadbridge P; Fukumoto Y; Kamiyama N; Mizoguchi Y; Polthier K; Saeki O (eds.), ROLE AND IMPORTANCE OF MATHEMATICS IN INNOVATION, SPRINGER-VERLAG SINGAPORE PTE LTD, JAPAN, Kyushu Univ, Ito Campus, Inst Math Ind, Fukuoka, pp. 35 - 50, presented at Forum on Math-for-Industry - Role and Importance of Mathematics in Innovation, JAPAN, Kyushu Univ, Ito Campus, Inst Math Ind, Fukuoka, 26 October 2015 - 30 October 2015, http://dx.doi.org/10.1007/978-981-10-0962-4_4

Preprints |

Hogan AB; Wu SL; Toor J; Doohan P; Watson OJ; Winskill P; Charles G; Barnsley G; Riley EM; Khoury DS; Ferguson NM; Ghani AC, Long Term Vaccination Strategies to Mitigate the Global Impact of SARS-CoV-2 Transmission: A Modelling Study, , http://dx.doi.org/10.2139/ssrn.4135323

Preprints |

Koutsakos M; Reynaldi A; Lee WS; Nguyen J; Amarasena T; Taiaroa G; Kinsella P; Liew KC; Tran T; Kent H; Tan H-X; Rowntree LC; Nguyen THO; Thomas P; Kedzierska K; Petersen J; Rossjohn J; Williamson D; Khoury D; Davenport M; Kent SJ; Wheatley AK; Juno JA, Rapid Recall and <i>de novo</i> T Cell Responses During SARS-CoV-2 Breakthrough Infection, , http://dx.doi.org/10.2139/ssrn.4311124

Early Career Fellowship, NHMRC (commenced 2018)

Discovery Project, ARC (commenced 2018)

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Dr David Khoury