Associate Professor Dorit Samocha-Bonet

Associate Professor Dorit Samocha-Bonet

Conjoint Associate Professor

Academic Record

2001 - 2006

PhD, Physiology and Pharmacology, Sackler School of Medicine, Tel-Aviv University, Israel.

1993 - 1996

MSc, Clinical Biochemistry, Sackler School of Medicine, Tel-Aviv University, Israel. With Honours.

1989 - 1992

BSc, Nutritional Sciences, Hebrew University, Faculty of Agricultural, Food and Environmental Quality Sciences, Israel. Cum Laude.

 

Other Qualifications

1993                                Dietitian (recognition by the Israeli Ministry of Health, Department of Medical Professions)

Medicine & Health
School of Clinical Medicine

Samocha-Bonet is Group leader, Clinical Insulin Resistance at the Healthy Ageing Theme at the Garvan Institute of Medical Research, and a Conjoint Senior Lecturer, School of Medical Sciences UNSW. Samocha-Bonet completed a BSc degree (Cum Laude) in Nutritional Sciences at the Hebrew University, Israel and joined the Nutrition & Dietetics Department at Tel Aviv Medical Centre as a clinical dietician where she worked for a decade (1993-2003). She completed MSc degree (with Honours) in Clinical Biochemistry (1996) and PhD in Physiology & Pharmacology (2006) at Tel Aviv University, Israel prior to relocating to Sydney. She joined the Garvan Institute of Medical Research in 2007 as a postdoctoral fellow. In 2013 she established the Clinical Insulin Resistance Group with a focus on exploring the metabolic factors underlying insulin resistance and insulin sensitivity in obesity and on developing approaches to promoting insulin sensitivity in obesity. She has been the Australian Diabetes Society (ADS) Skip Martin Early Career Fellow in 2011, and the recipient of the top ranked project grant from the Diabetes Australia Research Program in 2016.

Phone
+61292958309
Location
Garvan Institute of Medical Research 384 Victoria Street Darlinghurst 2010
  • Book Chapters | 2023
    Wark G; Samocha-Bonet D; Ghaly S; Danta M, 2023, 'The role of nutrition in inflammatory bowel disease: Disease associations, management of active disease and maintenance of remission', in Encyclopedia of Human Nutrition: Volume 1-4, Fourth Edition, Elsevier, pp. 669 - 697, http://dx.doi.org/10.1016/B978-0-12-821848-8.00104-9
    Book Chapters | 2015
    Greenfield JR; Samocha-Bonet D, 2015, 'Glutamine and glucagon-like peptide-1 response', in Rajendram R; Preedy VR; Patel VB (ed.), Glutamine in Clinical Nutrition, Springer, London, pp. 277 - 291, http://dx.doi.org/10.1007/978-1-4939-1932-1_21
  • Journal articles | 2024
    Katsoudas N; Tavakoli P; Wu N; Shapiro A; Leach ST; Williams A-J; Paramsothy R; Ghaly S; Connor SJ; Samocha-Bonet D; Lambert K; Hold GL, 2024, 'Dietary Emulsifier Exposure in People With Inflammatory Bowel Disease Compared With Healthy Controls: Is There a Cause for Concern?', Inflamm Bowel Dis, http://dx.doi.org/10.1093/ibd/izad318
    Journal articles | 2024
    Wark G; Kaakoush NO; Samocha-Bonet D; Ghaly S; Danta M, 2024, 'P1233 Serum insulin is associated with c-reactive protein and gut microbial diversity in inflammatory bowel disease', Journal of Crohn's and Colitis, 18, pp. i2183 - i2183, http://dx.doi.org/10.1093/ecco-jcc/jjad212.1363
    Journal articles | 2023
    Shalaby N; Samocha-Bonet D; Kaakoush NO; Danta M, 2023, 'The Role of the Gastrointestinal Microbiome in Liver Disease', Pathogens, 12, http://dx.doi.org/10.3390/pathogens12091087
    Journal articles | 2022
    Koay YC; Coster ACF; Chen DL; Milner B; Batarseh A; O’Sullivan JF; Greenfield JR; Samocha-Bonet D, 2022, 'Metabolomics and Lipidomics Signatures of Insulin Resistance and Abdominal Fat Depots in People Living with Obesity', Metabolites, 12, pp. 1272, http://dx.doi.org/10.3390/metabo12121272
    Journal articles | 2021
    Bishay RH; Tonks KT; George J; Samocha-Bonet D; Meyerowitz-Katz G; Chisholm DJ; James DE; Greenfield JR, 2021, 'Plasma Bile Acids More Closely Align with Insulin Resistance, Visceral and Hepatic Adiposity Than Total Adiposity', Journal of Clinical Endocrinology and Metabolism, 106, pp. E1131 - E1139, http://dx.doi.org/10.1210/clinem/dgaa940
    Journal articles | 2021
    Lambert K; Pappas D; Miglioretto C; Javadpour A; Reveley H; Frank L; Grimm MC; Samocha-Bonet D; Hold GL, 2021, 'Systematic review with meta-analysis: dietary intake in adults with inflammatory bowel disease', Alimentary Pharmacology and Therapeutics, 54, pp. 742 - 754, http://dx.doi.org/10.1111/apt.16549
    Journal articles | 2021
    Samocha-Bonet D; Wu B; Ryugo DK, 2021, 'Diabetes mellitus and hearing loss: A review', Ageing Research Reviews, 71, pp. 101423, http://dx.doi.org/10.1016/j.arr.2021.101423
    Journal articles | 2021
    Snaith JR; Samocha-Bonet D; Evans J; Liu Z; Kowalski G; Bruce C; Holmes-Walker DJ; Greenfield JR, 2021, 'Insulin resistance in type 1 diabetes managed with metformin (INTIMET): Study protocol of a double-blind placebo-controlled, randomised trial', Diabetic Medicine, 38, http://dx.doi.org/10.1111/dme.14564
    Journal articles | 2021
    Wark G; Samocha-Bonet D; Ghaly S; Danta M, 2021, 'The role of diet in the pathogenesis and management of inflammatory bowel disease: A review', Nutrients, 13, pp. 1 - 26, http://dx.doi.org/10.3390/nu13010135
    Journal articles | 2021
    Watt KI; Henstridge DC; Ziemann M; Sim CB; Montgomery MK; Samocha-Bonet D; Parker BL; Dodd GT; Bond ST; Salmi TM; Lee RS; Thomson RE; Hagg A; Davey JR; Qian H; Koopman R; El-Osta A; Greenfield JR; Watt MJ; Febbraio MA; Drew BG; Cox AG; Porrello ER; Harvey KF; Gregorevic P, 2021, 'Yap regulates skeletal muscle fatty acid oxidation and adiposity in metabolic disease', Nature Communications, 12, http://dx.doi.org/10.1038/s41467-021-23240-7
    Journal articles | 2021
    Williams AJ; Paramsothy R; Wu N; Ghaly S; Leach S; Paramsothy S; Corte C; O'Brien C; Burke C; Wark G; Samocha-Bonet D; Lambert K; Ahlenstiel G; Wasinger V; Dutt S; Pavli P; Grimm M; Lemberg D; Connor S; Leong R; Hold G, 2021, 'Australia IBD Microbiome (AIM) Study: Protocol for a multicentre longitudinal prospective cohort study', BMJ Open, 11, http://dx.doi.org/10.1136/bmjopen-2020-042493
    Journal articles | 2020
    Chalmers E; Samocha-Bonet D, 2020, 'The effect of body acid–base state and manipulations on body glucose regulation in human', European Journal of Clinical Nutrition, 74, pp. 20 - 26, http://dx.doi.org/10.1038/s41430-020-0692-6
    Journal articles | 2020
    Harari A; Coster ACF; Jenkins A; Xu A; Greenfield JR; Harats D; Shaish A; Samocha-Bonet D, 2020, 'Obesity and Insulin Resistance Are Inversely Associated with Serum and Adipose Tissue Carotenoid Concentrations in Adults', Journal of Nutrition, 150, pp. 38 - 46, http://dx.doi.org/10.1093/jn/nxz184
    Journal articles | 2020
    Htet TD; Godneva A; Liu Z; Chalmers E; Kolobkov D; Snaith JR; Richens R; Toth K; Danta M; Hng TM; Elinav E; Segal E; Greenfield JR; Samocha-Bonet D, 2020, 'Rationale and design of a randomised controlled trial testing the effect of personalised diet in individuals with pre-diabetes or type 2 diabetes mellitus treated with metformin', BMJ Open, 10, pp. e037859, http://dx.doi.org/10.1136/bmjopen-2020-037859
    Journal articles | 2020
    Montgomery MK; Bayliss J; Devereux C; Bezawork-Geleta A; Roberts D; Huang C; Schittenhelm RB; Ryan A; Townley SL; Selth LA; Biden TJ; Steinberg GR; Samocha-Bonet D; Meex RCR; Watt MJ, 2020, 'SMOC1 is a glucose-responsive hepatokine and therapeutic target for glycemic control', Science Translational Medicine, 12, http://dx.doi.org/10.1126/SCITRANSLMED.AAZ8048
    Journal articles | 2020
    Snaith JR; Samocha-Bonet D; Holmes-Walker DJ; Greenfield JR, 2020, 'MON-LB113 Insulin Resistance in Type 1 Diabetes Managed With Metformin (INTIMET): Rationale and Study Design of a Randomised Placebo-Controlled Trial', Journal of the Endocrine Society, 4, http://dx.doi.org/10.1210/jendso/bvaa046.2038
    Journal articles | 2020
    Wali JA; Koay YC; Chami J; Wood C; Corcilius L; Payne RJ; Rodionov RN; Birkenfeld AL; Samocha-Bonet D; Simpson SJ; O’Sullivan JF, 2020, 'Nutritional and metabolic regulation of the metabolite dimethylguanidino valeric acid: an early marker of cardiometabolic disease', American Journal of Physiology - Endocrinology and Metabolism, 319, pp. E509 - E518, http://dx.doi.org/10.1152/ajpendo.00207.2020
    Journal articles | 2019
    Bishay RH; Tonks KT; George J; Samocha-Bonet D; Chisholm DJ; James DE; Greenfield JR, 2019, 'Circulating bile acids are associated with insulin resistance and visceral and liver fat in human subjects', Obesity Research & Clinical Practice, 13, pp. 28 - 29, http://dx.doi.org/10.1016/j.orcp.2016.10.030
    Journal articles | 2019
    Koay YC; Yang P; Chen D; Jenkins AB; Greenfield J; O'Sullvan JF; Samocha-Bonet D, 2019, 'Novel circulating biomarkers identify insulin resistance phenotypes in obesity', Obesity Research & Clinical Practice, 13, pp. 267 - 268, http://dx.doi.org/10.1016/j.orcp.2018.11.092
    Journal articles | 2019
    Milder TY; Stocker SL; Samocha-Bonet D; Day RO; Greenfield JR, 2019, 'Sodium-glucose cotransporter 2 inhibitors for type 2 diabetes—cardiovascular and renal benefits in patients with chronic kidney disease', European Journal of Clinical Pharmacology, 75, pp. 1481 - 1490, http://dx.doi.org/10.1007/s00228-019-02732-y
    Journal articles | 2019
    Milder TY; Stocker SL; Shaheed CA; McGrath-Cadell L; Samocha-Bonet D; Greenfield JR; Day RO, 2019, 'Combination Therapy with an SGLT2 Inhibitor as Initial Treatment for Type 2 Diabetes: A Systematic Review and Meta-Analysis', JOURNAL OF CLINICAL MEDICINE, 8, http://dx.doi.org/10.3390/jcm8010045
    Journal articles | 2019
    Samocha-Bonet D, 2019, 'The diverse obesity phenotypes – Implication for treatment', Obesity Research & Clinical Practice, 13, pp. 243 - 243, http://dx.doi.org/10.1016/j.orcp.2018.11.021
    Journal articles | 2019
    Tang A; Tonks KT; Heilbronn LK; Pocock NA; Campbell LV; James DE; Chisholm DJ; Greenfield JR; Samocha-Bonet D, 2019, 'Insulin-sensitive overweight/obese individuals remain as insulin sensitive and normotensive as lean subjects over 6 years', Obesity Research & Clinical Practice, 13, pp. 35 - 35, http://dx.doi.org/10.1016/j.orcp.2016.10.042
    Journal articles | 2019
    2019, 'Longitudinal changes in insulin resistance in normal weight, overweight and obese individuals', , http://dx.doi.org/10.3390/jcm8050623
    Journal articles | 2018
    Du YT; Piscitelli D; Ahmad S; Trahair LG; Greenfield JR; Samocha-Bonet D; Rayner CK; Horowitz M; Jones KL, 2018, 'Effects of glutamine on gastric emptying of lowand high-nutrient drinks in healthy young subjects—impact on glycaemia', Nutrients, 10, http://dx.doi.org/10.3390/nu10060739
    Journal articles | 2018
    Elshorbagy AK; Samocha-Bonet D; Jernerén F; Turner C; Refsum H; Heilbronn LK, 2018, 'Food Overconsumption in Healthy Adults Triggers Early and Sustained Increases in Serum Branched-Chain Amino Acids and Changes in Cysteine Linked to Fat Gain', Journal of Nutrition, 148, pp. 1073 - 1080, http://dx.doi.org/10.1093/jn/nxy062
    Journal articles | 2018
    Fazakerley DJ; Chaudhuri R; Yang P; Maghzal GJ; Thomas KC; Krycer JR; Humphrey SJ; Parker BL; Fisher-Wellman KH; Meoli CC; Hoffman NJ; Diskin C; Burchfield JG; Cowley MJ; Kaplan W; Modrusan Z; Kolumam G; Yang JYH; Chen DL; Samocha-Bonet D; Greenfield JR; Hoehn KL; Stocker R; James DE; Chen D; Southwell Keely P, 2018, 'Mitochondrial CoQ deficiency is a common driver of mitochondrial oxidants and insulin resistance', eLife, 7, pp. e32111, http://dx.doi.org/10.7554/elife.32111
    Journal articles | 2018
    Ma C; Tonks KT; Center JR; Samocha-Bonet D; Greenfield JR, 2018, 'Complex interplay among adiposity, insulin resistance and bone health', Clinical Obesity, 8, pp. 131 - 139, http://dx.doi.org/10.1111/cob.12240
    Journal articles | 2018
    Samocha-Bonet D; Debs S; Greenfield JR, 2018, 'Prevention and Treatment of Type 2 Diabetes: A Pathophysiological-Based Approach', Trends in Endocrinology and Metabolism, 29, pp. 370 - 379, http://dx.doi.org/10.1016/j.tem.2018.03.014
    Journal articles | 2017
    Chen DLT; Brown R; Liess C; Poljak A; Xu A; Zhang J; Trenell M; Jenkins A; Chisholm D; Samocha-Bonet D; Macefield VG; Greenfield JR; Chen D; Milliken S; Goodnow C, 2017, 'Muscle sympathetic nerve activity is associated with liver insulin sensitivity in obese non-diabetic men', Frontiers in Physiology, 8, pp. 101, http://dx.doi.org/10.3389/fphys.2017.00101
    Journal articles | 2017
    Kozan P; Blythe JC; Greenfield JR; Samocha-Bonet D, 2017, 'The effect of buffering high acid load meal with sodium bicarbonate on postprandial glucose metabolism in humans—A randomized placebo-controlled study', Nutrients, 9, pp. 861, http://dx.doi.org/10.3390/nu9080861
    Journal articles | 2017
    Mackie GM; Samocha-Bonet D; Tam CS, 2017, 'Does weight cycling promote obesity and metabolic risk factors?', Obesity Research and Clinical Practice, 11, pp. 131 - 139, http://dx.doi.org/10.1016/j.orcp.2016.10.284
    Journal articles | 2017
    Tam CS; Chaudhuri R; Hutchison AT; Samocha-Bonet D; Heilbronn LK, 2017, 'Skeletal muscle extracellular matrix remodeling after short-term overfeeding in healthy humans', Metabolism: Clinical and Experimental, 67, pp. 26 - 30, http://dx.doi.org/10.1016/j.metabol.2016.10.009
    Journal articles | 2017
    Tonks KT; White CP; Center JR; Samocha-Bonet D; Greenfield JR, 2017, 'Bone turnover is suppressed in insulin resistance, independent of adiposity', Journal of Clinical Endocrinology and Metabolism, 102, pp. 1112 - 1121, http://dx.doi.org/10.1210/jc.2016-3282
    Journal articles | 2016
    Chen DL; Liess C; Poljak A; Xu A; Zhang J; Thoma C; Trenell M; Milner B; Jenkins AB; Chisholm DJ; Samocha-Bonet D; Greenfield JR, 2016, 'Erratum: Phenotypic Characterization of Insulin-Resistant and Insulin-Sensitive Obesity (Journal of Clinical Endocrinology and Metabolism 2015 100(11): (4082-4091)); doi: 10.1210/jc.2015-2712', Journal of Clinical Endocrinology and Metabolism, 101, pp. 757, http://dx.doi.org/10.1210/jc.2015-4260
    Journal articles | 2016
    Elshorbagy AK; Jernerén F; Samocha-Bonet D; Refsum H; Heilbronn LK, 2016, 'Serum S-adenosylmethionine, but not methionine, increases in response to overfeeding in humans', Nutrition and Diabetes, 6, http://dx.doi.org/10.1038/nutd.2015.44
    Journal articles | 2016
    He J; Chen DL; Samocha-Bonet D; Gillinder KR; Barclay JL; Magor GW; Perkins AC; Greenfield JR; Yang G; Whitehead JP, 2016, 'Fibroblast growth factor-1 (FGF-1) promotes adipogenesis by downregulation of carboxypeptidase A4 (CPA4)–a negative regulator of adipogenesis implicated in the modulation of local and systemic insulin sensitivity', Growth Factors, 34, pp. 210 - 216, http://dx.doi.org/10.1080/08977194.2017.1285764
    Journal articles | 2016
    Lee-Young RS; Hoffman NJ; Murphy KT; Henstridge DC; Samocha-Bonet D; Siebel AL; Iliades P; Zivanovic B; Hong YH; Colgan TD; Kraakman MJ; Bruce CR; Gregorevic P; McConell GK; Lynch GS; Drummond GR; Kingwell BA; Greenfield JR; Febbraio MA; Milliken S; Goodnow C, 2016, 'Glucose-6-phosphate dehydrogenase contributes to the regulation of glucose uptake in skeletal muscle', Molecular Metabolism, 5, pp. 1083 - 1091, http://dx.doi.org/10.1016/j.molmet.2016.09.002
    Journal articles | 2016
    Radhakutty A; Mangelsdorf BL; Drake SM; Samocha-Bonet D; Heilbronn LK; Smith MD; Thompson CH; Burt MG, 2016, 'Effects of prednisolone on energy and fat metabolism in patients with rheumatoid arthritis: tissue-specific insulin resistance with commonly used prednisolone doses', Clinical Endocrinology, 85, pp. 741 - 747, http://dx.doi.org/10.1111/cen.13138
    Journal articles | 2016
    Radhakutty A; Mangelsdorf BL; Drake SM; Samocha-Bonet D; Jenkins AB; Heilbronn LK; Smith MD; Thompson CH; Burt MG, 2016, 'Effect of acute and chronic glucocorticoid therapy on insulin sensitivity and postprandial vascular function', Clinical Endocrinology, 84, pp. 501 - 508, http://dx.doi.org/10.1111/cen.12966
    Journal articles | 2016
    Tonks KT; Coster AC; Christopher MJ; Chaudhuri R; Xu A; Gagnon-Bartsch J; Chisholm DJ; James DE; Meikle PJ; Greenfield JR; Samocha-Bonet D; Milliken S; Goodnow C, 2016, 'Skeletal muscle and plasma lipidomic signatures of insulin resistance and overweight/obesity in humans', Obesity, 24, pp. 908 - 916, http://dx.doi.org/10.1002/oby.21448
    Journal articles | 2016
    Williams RS; Kozan P; Samocha-Bonet D, 2016, 'The role of dietary acid load and mild metabolic acidosis in insulin resistance in humans', Biochimie, 124, pp. 171 - 177, http://dx.doi.org/10.1016/j.biochi.2015.09.012
    Journal articles | 2015
    Chaudhuri R; Khoo PS; Tonks K; Junutula JR; Kolumam G; Modrusan Z; Samocha-Bonet D; Meoli CC; Hocking S; Fazakerley DJ; Stöckli J; Hoehn KL; Greenfield JR; Yang JYH; James DE; Milliken S; Goodnow C, 2015, 'Cross-species gene expression analysis identifies a novel set of genes implicated in human insulin sensitivity', npj Systems Biology and Applications, 1, pp. 15010, http://dx.doi.org/10.1038/npjsba.2015.10
    Journal articles | 2015
    Chen DL; Liess C; Poljak A; Xu A; Zhang J; Thoma C; Trenell M; Milner B; Jenkins AB; Chisholm DJ; Samocha-Bonet D; Greenfield JR, 2015, 'Phenotypic characterization of insulin-resistant and insulin-sensitive obesity', Journal of Clinical Endocrinology and Metabolism, 100, pp. 4082 - 4091, http://dx.doi.org/10.1210/jc.2015-2712
    Journal articles | 2015
    Samocha-Bonet D; Chisholm DJ; Holst JJ; Greenfield JR; Milliken S; Goodnow C, 2015, 'L-glutamine and whole protein restore first-phase insulin response and increase glucagon-like peptide-1 in type 2 diabetes patients', Nutrients, 7, pp. 2101 - 2108, http://dx.doi.org/10.3390/nu7042101
    Journal articles | 2015
    Williams RS; Heilbronn LK; Chen DL; Coster A; Greenfield JR; Samocha-Bonet D; Milliken S; Goodnow C; Chen D, 2015, 'Dietary acid load, metabolic acidosis and insulin resistance - Lessons from cross-sectional and overfeeding studies in humans', Clinical Nutrition, 35, pp. 1084 - 1090, http://dx.doi.org/10.1016/j.clnu.2015.08.002
    Journal articles | 2014
    Milner KL; Jenkins AB; Trenell M; Tid-Ang J; Samocha-Bonet D; Weltman M; Xu A; George J; Chisholm DJ, 2014, 'Eradicating hepatitis C virus ameliorates insulin resistance without change in adipose depots', Journal of Viral Hepatitis, 21, pp. 325 - 332, http://dx.doi.org/10.1111/jvh.12143
    Journal articles | 2014
    Samocha-Bonet D; Chisholm DJ; Gribble FM; Coster ACF; Carpenter KH; Jones GRD; Holst JJ; Greenfield JR, 2014, 'Glycemic effects and safety of L-glutamine supplementation with or without sitagliptin in type 2 diabetes patients-a randomized study', PLoS ONE, 9, pp. e113366, http://dx.doi.org/10.1371/journal.pone.0113366
    Journal articles | 2014
    Samocha-Bonet D; Dixit VD; Kahn CR; Leibel RL; Lin X; Nieuwdorp M; Pietiläinen KH; Rabasa-Lhoret R; Roden M; Scherer PE; Klein S; Ravussin E, 2014, 'Metabolically healthy and unhealthy obese - The 2013 stock conference report', Obesity Reviews, 15, pp. 697 - 708, http://dx.doi.org/10.1111/obr.12199
    Journal articles | 2014
    Samocha-Bonet D; Karelis AD; Rabasa-Lhoret R, 2014, 'Metabolically Healthy Overweight and Obesity', Annals of Internal Medicine, http://dx.doi.org/10.7326/L14-5007-2
    Journal articles | 2014
    Samocha-Bonet D; Tam CS; Campbell LV; Heilbronn LK, 2014, 'Raised circulating fetuin-a after 28-day overfeeding in healthy humans', Diabetes Care, 37, http://dx.doi.org/10.2337/dc13-1728
    Journal articles | 2014
    Sato K; Samocha-Bonet D; Handelsman DJ; Fujita S; Wittert GA; Heilbronn LK, 2014, 'Serum sex steroids and steroidogenesis-related enzyme expression in skeletal muscle during experimental weight gain in men', Diabetes and Metabolism, 40, pp. 439 - 444, http://dx.doi.org/10.1016/j.diabet.2014.03.006
    Journal articles | 2014
    Tonks K; White C; Center J; Chisholm DJ; Greenfield JR; Samocha-Bonet D, 2014, 'Bone phenotype of insulin-resistant and insulin-sensitive overweight and obese humans', Obesity Research & Clinical Practice, 8, pp. 103 - 104, http://dx.doi.org/10.1016/j.orcp.2014.10.189
    Journal articles | 2014
    Wu LE; Samocha-Bonet D; Whitworth PT; Fazakerley DJ; Turner N; Biden TJ; James DE; Cantley J, 2014, 'Identification of fatty acid binding protein 4 as an adipokine that regulates insulin secretion during obesity', Molecular Metabolism, 3, pp. 465 - 473, http://dx.doi.org/10.1016/j.molmet.2014.02.005
    Journal articles | 2013
    Chang J; Wu T; Greenfield JR; Samocha-Bonet D; Horowitz M; Rayner CK, 2013, 'Effects of Intraduodenal Glutamine on Incretin Hormone and Insulin Release, the Glycemic Response to an Intraduodenal Glucose Infusion, and Antropyloroduodenal Motility in Health and Type 2 Diabetes', Diabetes Care, 36, pp. 2262 - 2265, http://dx.doi.org/10.2337/dc12-1663
    Journal articles | 2013
    Heilbronn LK; Campbell LV; Xu A; Samocha-Bonet D, 2013, 'Metabolically Protective Cytokines Adiponectin and Fibroblast Growth Factor-21 Are Increased by Acute Overfeeding in Healthy Humans', PLoS ONE, 8, http://dx.doi.org/10.1371/journal.pone.0078864
    Journal articles | 2013
    Heilbronn LK; Coster ACF; Campbell LV; Greenfield JR; Lange K; Christopher MJ; Meikle PJ; Samocha-Bonet D, 2013, 'The effect of short-term overfeeding on serum lipids in healthy humans', Obesity, 21, pp. e649 - e659, http://dx.doi.org/10.1002/oby.20508
    Journal articles | 2013
    Hocking S; Samocha-Bonet D; Milner KL; Greenfield JR; Chisholm DJ, 2013, 'Adiposity and insulin resistance in humans: The role of the different tissue and cellular lipid depots', Endocrine Reviews, 34, pp. 463 - 500, http://dx.doi.org/10.1210/er.2012-1041
    Journal articles | 2013
    Jenkins AB; Batterham M; Samocha-Bonet D; Tonks K; Greenfield JR; Campbell LV, 2013, 'Segregation of a Latent High Adiposity Phenotype in Families with a History of Type 2 Diabetes Mellitus Implicates Rare Obesity-Susceptibility Genetic Variants with Large Effects in Diabetes-Related Obesity', PLoS ONE, 8, http://dx.doi.org/10.1371/journal.pone.0070435
    Journal articles | 2013
    Samocha-Bonet D, 2013, 'Insulin-sensitive obesity in humans', Obesity Research & Clinical Practice, 7, pp. e24 - e24, http://dx.doi.org/10.1016/j.orcp.2013.12.547
    Journal articles | 2013
    Tonks KT; Ng Y; Miller S; Coster ACF; Samocha-Bonet D; Iseli TJ; Xu A; Patrick E; Yang JYH; Junutula JR; Modrusan Z; Kolumam G; Stöckli J; Chisholm DJ; James DE; Greenfield JR; Stoeckli J, 2013, 'Impaired Akt phosphorylation in insulin-resistant human muscle is accompanied by selective and heterogeneous downstream defects', Diabetologia, 56, pp. 875 - 885, http://dx.doi.org/10.1007/s00125-012-2811-y
    Journal articles | 2012
    Gentilcore D; Ahmad S; Jones K; Greenfield J; Samocha-Bonet D; Mckinnon R, 2012, 'Effects of the amino acid, glutamine, on gastric emptying and the glycaemic response to oral glucose in healthry young subjects', NEUROGASTROENTEROLOGY AND MOTILITY, 24, pp. 170 - 170, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000308435400561&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 2012
    Gregersen S; Samocha-Bonet D; Heilbronn LK; Campbell LV, 2012, 'Inflammatory and oxidative stress responses to high-carbohydrate and high-fat meals in healthy humans', J Nutr Metab, pp. 238056, http://dx.doi.org/10.1155/2012/238056
    Journal articles | 2012
    Lichtenberg DA; Samocha-Bonet D; Pinchuk I, 2012, 'Inhibition of the Peroxidation of Liposomal Lipids by Uric Acid Requires Tocopherol', BIOPHYSICAL JOURNAL, 102, pp. 292A - 292A, http://dx.doi.org/10.1016/j.bpj.2011.11.1616
    Journal articles | 2012
    Samocha-Bonet D; Campbell LV; Mori TA; Croft KD; Greenfield JR; Turner N; Heilbronn LK, 2012, 'Overfeeding reduces insulin sensitivity and increases oxidative stress, without altering markers of mitochondrial content and function in humans', PLoS One, 7, pp. e36320, http://dx.doi.org/10.1371/journal.pone.0036320
    Journal articles | 2012
    Samocha-Bonet D; Chisholm DJ; Tonks K; Campbell LV; Greenfield JR, 2012, 'Insulin-sensitive obesity in humans - a 'favorable fat' phenotype?', Trends Endocrinol Metab, 23, pp. 116 - 124, http://dx.doi.org/10.1016/j.tem.2011.12.005
    Journal articles | 2012
    Viardot A; Heilbronn LK; Samocha-Bonet D; Mackay F; Campbell LV; Samaras K, 2012, 'Obesity is associated with activated and insulin resistant immune cells', Diabetes/metabolism research and reviews, 28, pp. 447 - 454, http://dx.doi.org/10.1002/dmrr.2302
    Journal articles | 2011
    Heilbronn LK; Meikle P; Campbell LV; Samocha-Bonet D, 2011, 'Metabolic consequences of over-nutrition and weight gain in humans', Obesity Research & Clinical Practice, 5, pp. 4 - 4, http://dx.doi.org/10.1016/j.orcp.2011.08.057
    Journal articles | 2011
    Jenkins AB; Samocha-Bonet D; Batterham M; Purtell L; Gregersen S; Heilbronn L; Tonks K; Campbell LV, 2011, 'Increased body fat content and waist circumference in healthy individuals with a family history of type 2 diabetes supports co-inheritance of susceptibilities to weight gain and type 2 diabetes', Obesity Research & Clinical Practice, 5, pp. 46 - 47, http://dx.doi.org/10.1016/j.orcp.2011.08.145
    Journal articles | 2011
    Samocha-Bonet D; Wong O; Synnott EL; Piyaratna N; Douglas A; Gribble FM; Holst JJ; Chisholm DJ; Greenfield JR, 2011, 'Glutamine reduces postprandial glycemia and augments the glucagon-like peptide-1 response in type 2 diabetes patients', J Nutr, 141, pp. 1233 - 1238, http://dx.doi.org/10.3945/jn.111.139824
    Journal articles | 2011
    Tonks KT; Ng Y; Miller S; Coster ACF; Samocha-Bonet D; Iseli TJ; Xu A; Stöckli J; Chisholm DJ; James DE; Greenfield JR, 2011, 'Obese, yet insulin sensitive humans', Obesity Research & Clinical Practice, 5, pp. 13 - 13, http://dx.doi.org/10.1016/j.orcp.2011.08.079
    Journal articles | 2010
    Samocha-Bonet D; Campbell LV; Viardot A; Freund J; Tam CS; Greenfield JR; Heilbronn LK, 2010, 'A family history of type 2 diabetes increases risk factors associated with overfeeding', Diabetologia, 53, pp. 1700 - 1708
    Journal articles | 2010
    Samocha-Bonet D; Heilbronn LK; Lichtenberg D; Campbell LV, 2010, 'Does skeletal muscle oxidative stress initiate insulin resistance in genetically predisposed individuals?', Trends Endocrinol Metab, 21 (2), pp. 83 - 87, http://dx.doi.org/10.1016/j.tem.2009.09.008
    Journal articles | 2010
    Tam CS; Viardot A; Clement K; Tordjman J; Tonks K; Greenfield JR; Campbell LV; Samocha-Bonet D; Heilbronn LK, 2010, 'Short-term overfeeding may induce peripheral insulin resistance without altering subcutaneous adipose tissue macrophages in humans', Diabetes, 59, pp. 2164 - 2170, http://dx.doi.org/10.2337/db10-0162
    Journal articles | 2008
    Samocha-Bonet D; Justo D; Rogowski O; Saar N; Abu-Abeid S; Shenkerman G; Shapira I; Berliner S; Tomer A, 2008, 'Platelet counts and platelet activation markers in obese subjects', Mediators of Inflammation, 2008, http://dx.doi.org/10.1155/2008/834153
    Journal articles | 2007
    Shapira I; Rogowski O; Samocha-Bonet D; Berliner S, 2007, 'Inflammation related erythrocyte aggregation and obesity. Possible link to cardiovascular morbidity', ATHEROSCLEROSIS SUPPLEMENTS, 8, pp. 178 - 178, http://dx.doi.org/10.1016/S1567-5688(07)71673-2
    Journal articles | 2007
    Shapira I; Rogowski O; Samocha-Bonet D; Berliner S, 2007, 'P1-16 INFLAMMATION RELATED ERYTHROCYTE AGGREGATION AND OBESITY. POSSIBLE LINK TO CARDIOVASCULAR MORBIDITY', International Journal of Cardiology, 122, pp. S66 - S66, http://dx.doi.org/10.1016/s0167-5273(08)70542-4
    Journal articles | 2005
    Assayag EB; Bornstein N; Shapira I; Mardi T; Goldin Y; Tolshinski T; Vered Y; Zakuth V; Burke M; Berliner S; Bonet DS, 2005, 'Inflammation-sensitive proteins and erythrocyte aggregation in atherothrombosis', Int J Cardiol, 98, pp. 271 - 276, http://dx.doi.org/10.1016/j.ijcard.2003.12.013
    Journal articles | 2005
    Samocha-Bonet D; Lichtenberg D; Pinchuk I, 2005, 'Kinetic studies of copper-induced oxidation of urate, ascorbate and their mixtures', J Inorg Biochem, 99, pp. 1963 - 1972, http://dx.doi.org/10.1016/j.jinorgbio.2005.06.006
    Journal articles | 2004
    Berliner S; Ben-Ami R; Samocha-Bonet D; Abu-Abeid S; Schechner V; Beigel Y; Shapira I; Yedgar S; Barshtein G, 2004, 'The degree of red blood cell aggregation on peripheral blood glass slides corresponds to inter-erythrocyte cohesive forces in laminar flow', Thrombosis Research, 114, pp. 37 - 44, http://dx.doi.org/10.1016/j.thromres.2004.04.009
    Journal articles | 2004
    Samocha-Bonet D; Ben-Ami R; Shapira I; Shenkerman G; Abu-Abeid S; Stern N; Mardi T; Tulchinski T; Deutsch V; Yedgar S; Barshtein G; Berliner S, 2004, 'Flow-resistant red blood cell aggregation in morbid obesity', International Journal of Obesity, 28, pp. 1528 - 1534, http://dx.doi.org/10.1038/sj.ijo.0802791
    Journal articles | 2004
    Samocha-Bonet D; Gal S; Schnitzer E; Lichtenberg D; Pinchuk I, 2004, 'Lipid peroxidation in the presence of albumin, inhibitory and prooxidative effects', Free Radical Research, 38, pp. 1173 - 1181, http://dx.doi.org/10.1080/10715760400016113
    Journal articles | 2003
    Samocha-Bonet D; Lichtenberg D; Tomer A; Deutsch V; Mardi T; Goldin Y; Abu-Abeid S; Shenkerman G; Patshomik H; Shapira I; Berliner S, 2003, 'Enhanced erythrocyte adhesiveness/aggregation in obesity corresponds to low-grade inflammation', Obesity Research, 11, pp. 403 - 407, http://dx.doi.org/10.1038/oby.2003.54
    Journal articles | 2003
    Shapira I; Rogowski O; Justo D; Samocha-Bonet D; Mardi T; Goldin Y; Tulshinski T; Shenkerman G; Stern N; Abu-Abeid S; Zeltser D, 2003, '2P-0387 Morbid obesity association with increased erythrocyte adhesiveness/aggregation in the peripheral blood. Possible implications for the pathophysiology of the disease', Atherosclerosis Supplements, 4, pp. 124 - 124, http://dx.doi.org/10.1016/s1567-5688(03)90529-0
    Journal articles | 2003
    Shapira I; Rogowski O; Samocha-Bonet D; Goldin Y; Tulshinski T; Mardi T; Shenkerman G; Abu-Abeid S; Stern N; Zeltser D; Berliner S, 2003, '2P-0388 The detection of low-grade and smoldering internal inflammation in obese individuals — Comparative analysis between C-reactive protein and other simple biomarkers', Atherosclerosis Supplements, 4, pp. 124 - 124, http://dx.doi.org/10.1016/s1567-5688(03)90530-7
    Journal articles | 2003
    Shapira I; Rogowski O; Zeltser D; Serov J; Justo D; Samocha-Bonet D; Ben-Assayag E; Berliner S, 2003, 'The elevated leukocyte count in individuals with atherothrombotic risk factors is associated with increased leukocyte adhesiveness/aggregation', ATHEROSCLEROSIS SUPPLEMENTS, 4, pp. 206 - 206, http://dx.doi.org/10.1016/S1567-5688(03)90879-8
    Journal articles | 1999
    Soffery ; Samocha-Bone D; Weissenberg R; Madgar Y; Golan R; Shochat L; Lewin LM, 1999, 'Defaut de decondensation nucleaire du sperme humain détecte par la cytometrie en flux', Andrologie, 9, pp. 117
    Journal articles | 1998
    Samocha-Bone D; Lewin LM; Weissenberg R; Madgar Y; Soffer Y; Shochat L; Golan R, 1998, 'In-vitro human spermatozoa nuclear decondensation assessed by flow cytometry', Mol Hum Reprod, 4, pp. 133 - 137, http://dx.doi.org/10.1093/molehr/4.2.133
  • Conference Papers | 2022
    Reveley H; Frank L; Javadpour A; Samocha-Bonet D; Hold G; Lambert K, 2022, 'Emulsifier intake in a cohort of Australians with inflammatory bowel disease', in JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, WILEY, pp. 219 - 219, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000852585700328&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2022
    Tavakoli P; Wu N; Shapiro AJ; Sanchez-Lomba B; Pipicella JL; Lo L; Williams A-J; Ghaly S; Leach ST; Corte C; Burke C; Samocha-Bonet D; Lambert K; Wasinger V; Dutt S; Pavli P; Grimm MC; Lemberg D; Connor S; Leong R; Hold G; Paramsothy R; O'Brien C, 2022, 'A snapshot of inflammatory bowel disease in Australia: Interim analysis of the Australian IBD Microbiome (AIM) Study cohort', in JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, WILEY, Vol. 37, pp. 159 - 159, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000852585700240&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2022
    Wark G; Kaakoush N; Samocha-Bonet D; Ghaly S; Danta M, 2022, 'Body mass index is associated with reduced stool diversity in patients with inflammatory bowel disease: Key dietary considerations in management', in JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, WILEY, Vol. 37, pp. 103 - 103, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000852585700165&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2022
    Wark G; Kaakoush N; Samocha-Bonet D; Ghaly S; Danta M, 2022, 'Fasting insulin level correlates with microbial diversity in patients with inflammatory bowel disease', in JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, WILEY, Vol. 37, pp. 103 - 104, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000852585700166&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2020
    Wark G; Shi Y; Read M; Burke C; Samocha-Bonet D; Macia L; Ghaly S; Danta M, 2020, 'A machine learning algorithm based on a combination of an individual's meal features, microbiome, and activity can predict postprandial glycemic response in inflammatory bowel disease', in JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, WILEY, Vol. 35, pp. 134 - 135, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000589476200194&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2018
    Du YT; Piscitelli D; Ahmad S; Trahair LG; Greenfield JR; Samocha-Bonet D; Rayner CK; Horowitz M; Jones KL, 2018, 'Effects of glutamine on gastric emptying of low- and high-nutrient drinks in healthy young subjects: impact on glycaemia', in DIABETOLOGIA, SPRINGER, GERMANY, Berlin, Vol. 61, pp. S335 - S335, presented at 54th Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), GERMANY, Berlin, 01 October 2018 - 05 October 2018, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000443556004057&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2016
    Elshorbagy AK; Jerneren F; Samocha-Bonet D; Refsum H; Heilbronn LK, 2016, 'Plasma S-adenosylmethionine, but not methionine, increases in response to overfeeding in humans', in AMINO ACIDS, SPRINGER WIEN, pp. 629 - 629, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000369307700064&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2015
    Chen DLT; Chisholm D; Brown R; Macefield V; Samocha-Bonet D; Greenfield J, 2015, 'Liver insulin sensitivity is linked with resting sympathetic nervous activity in non-diabetic obese men', in DIABETOLOGIA, SPRINGER, SWEDEN, Stockholm, Vol. 58, pp. S121 - S121, presented at 51st Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), SWEDEN, Stockholm, 14 September 2015 - 18 September 2015, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000359820900241&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2015
    Tang A; Tonks K; Pocock N; Campbell LV; Chisholm DJ; Samocha-Bonet D; Greenfield JR, 2015, 'Lower Visceral Android Fat Mass Identifies Insulin-Sensitive Overweight / Obese Women, but Not Men', in Lower Visceral Android Fat Mass Identifies Insulin-Sensitive Overweight / Obese Women, but Not Men, ENDO 2015, presented at ENDO 2015, 05 March 2015 - 08 March 2015
    Conference Papers | 2015
    Tonks K; White C; Center J; Chisholm DJ; Greenfield JR; Samocha-Bonet D, 2015, 'Bone Turnover Markers Are Suppressed in Insulin Resistant Humans, Independent of Adiposity, Suggesting Bone Remains Insulin Responsive in Insulin Resistant States', in Bone Turnover Markers Are Suppressed in Insulin Resistant Humans, Independent of Adiposity, Suggesting Bone Remains Insulin Responsive in Insulin Resistant States, ENDO 2015, presented at ENDO 2015, 05 March 2015 - 08 January 2015
    Conference Papers | 2014
    Chen DLT; Samocha-Bonet D; Liess C; Poljak A; Xu A; Zhang J; Thoma C; Trenell M; Jenkins A; Milner B; Chisholm DC; Greenfield JR, 2014, 'Dual Insulin Resistance in Muscle and Liver, but Not a Single Site, Is Associated with Visceral and Liver Lipid Accumulation in Obesity', in Clinical Studies in Obesity: Endocrine Society, USA, presented at Endo, USA, 21 June 2014 - 24 June 2014
    Conference Papers | 2010
    Samocha-Bonet D; Turner N; Mori TA; Croft K; Viardot A; Tam CS; Greenfield JR; Campbell LV; Heilbronn LK, 2010, 'Short-Term Overfeeding and Moderate Weight Gain Induces Peripheral Insulin Resistance and Increases Systemic Oxidative Stress in Healthy Humans', in DIABETES, AMER DIABETES ASSOC, FL, Orlando, pp. A422 - A422, presented at 70th Annual Meeting of the American-Diabetes-Association, FL, Orlando, 25 June 2010 - 29 June 2010, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000278844602211&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2009
    Heilbronn L; Samocha-Bonet D; Viardot A; Tam C; Campbell L, 2009, 'Experimental Weight Gain Induces Insulin Resistance without Altering Adipose Tissue Macrophages in Individuals with and without a Family History of Type 2 Diabetes', in OBESITY, NATURE PUBLISHING GROUP, DC, Washington, pp. S72 - S72, presented at 27th Annual Scientific Meeting of the Obesity-Society, DC, Washington, 24 October 2009 - 28 October 2009, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000271237800087&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2009
    Viardot A; Samocha-Bonet D; Greenfield JR; Campbell LV; Heilbronn LK, 2009, 'Experimental weight gain in humans induces insulin resistance in absence of systemic or adipose tissue inflammation', in DIABETOLOGIA, SPRINGER, AUSTRIA, Vienna, pp. S74 - S74, presented at 45th Annual Meeting of the European-Association-for-the-Study-of-Diabetes, AUSTRIA, Vienna, 30 September 2009 - 02 October 2009, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000269262400165&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2008
    Viardot AC; Samocha-Bonet D; Greenfield JR; Campbell LV; Heilbronn L, 2008, 'Experimental weight gain in humans induces insulin resistance in absence of systemic or adipose tissue inflammation', in Diabetologia, Springer, New York, NY, USA, pp. 164 - 165, presented at Diabetologia
    Conference Papers | 2007
    Shapira I; Rogowski O; Samocha-Bonet D; Berliner S, 2007, 'Inflammation related erythrocyte aggregation and obesity. Possible link to cardiovascular morbidity', in INTERNATIONAL JOURNAL OF CARDIOLOGY, ELSEVIER IRELAND LTD, pp. 66 - 66, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000252310200254&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2005
    Shapira I; Rogowski O; Samocha-Bonet D; Goldin Y; Tolshinsky T; Mardi T; Zeltser D; Berliner S, 2005, 'The detection of low-grade and smoldering internal inflammation in obese individuals', in Kimchi A (ed.), ADVANCES IN HEART DISEASE, MEDIMOND S R L, CANADA, Vancouver, pp. 293 - +, presented at 12th World Congress on Heart Disease, CANADA, Vancouver, 16 July 2005 - 19 July 2005, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000243576100049&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2003
    Samocha-Bonet D; Justo D; Rogowski O; Deutsch V; Abu-Abied S; Shenkerman G; Lichtenberg D; Zeltser D; Mardi T; Shapira I; Berliner S; Tomer A, 2003, 'Platelet count and activation in obesity', in EXPERIMENTAL HEMATOLOGY, ELSEVIER SCIENCE INC, FRANCE, PARIS, pp. 167 - 167, presented at 32nd Annual Scientific Meeting of the International-Society-for-Experimental-Hematology, FRANCE, PARIS, 05 July 2003 - 08 July 2003, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000184162600307&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2003
    Samocha-Bonet D; Justo D; Rogowsky O; Deutsch V; Abu-Abied S; Shenkerman G; Zeltser D; Mardi T; Shapira I; Berliner S; Tomer A, 2003, 'Platelet count and activation in obesity.', in BLOOD, AMER SOC HEMATOLOGY, CALIFORNIA, SAN DIEGO, pp. 67B - 67B, presented at 45th Annual Meeting of the American-Society-of-Hematology, CALIFORNIA, SAN DIEGO, 06 December 2003 - 09 December 2003, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000186537100263&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2003
    Shapira I; Justo D; Marilus R; Mardi T; Tulshinski T; Goldin Y; Rozenblat M; Rogowski O; Yerushalmi Y; Stern N; Shenkerman G; Zeltser D; Berliner S, 2003, 'The appearance of aggregated erythrocytes in the peripheral blood of individuals with insulin resistance', in ATHEROSCLEROSIS SUPPLEMENTS, ELSEVIER IRELAND LTD, JAPAN, KYOTO, pp. 124 - 124, presented at 13th International Symposium on Atherosclerosis, JAPAN, KYOTO, 28 September 2003 - 02 October 2003, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000186926500528&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2003
    Shapira I; Rogowski O; Justo D; Samocha-Bonet D; Mardi T; Goldin Y; Tulshinski T; Shenkerman G; Stern N; Abu-Abeid S; Zeltser D, 2003, 'Morbid obesity association with increased erythrocyte adhesiveness/aggregation in the peripheral blood. Possible implications for the pathophysiology of the disease', in ATHEROSCLEROSIS SUPPLEMENTS, ELSEVIER IRELAND LTD, JAPAN, KYOTO, pp. 124 - 124, presented at 13th International Symposium on Atherosclerosis, JAPAN, KYOTO, 28 September 2003 - 02 October 2003, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000186926500526&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2003
    Shapira I; Rogowski O; Samocha-Bonet D; Goldin Y; Tulshinski T; Mardi T; Shenkerman G; Abu-Abeid S; Stern N; Zeltser D; Berliner S, 2003, 'The detection of low-grade and smoldering internal inflammation in obese individuals - Comparative analysis between C-reactive protein and other simple biomarkers', in ATHEROSCLEROSIS SUPPLEMENTS, ELSEVIER IRELAND LTD, JAPAN, KYOTO, pp. 124 - 124, presented at 13th International Symposium on Atherosclerosis, JAPAN, KYOTO, 28 September 2003 - 02 October 2003, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000186926500527&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Research at the Clinical Insulin Resistance Group at the Garvan is focused on uncovering the molecular pathways involved in the transition from health to insulin resistance and metabolic disease related to overweight and obesity in humans. In our clinical studies, we use gold-standard protocols to deeply phenotype individuals at risk of type 2 diabetes. Using gold-standard tools to characterise whole-body glucose regulation, abdominal fat distribution and liver fat, we find a wide range of phenotypic variation in obesity and prediabetes.

Current projects:

  1. A randomised clinical trial (https://clinicaltrials.gov/NCT03558867) to test the efficacy of an algorithm-based (personalised) diet in combination with metformin on glycaemia in individuals with prediabetes and type 2 diabetes (in collaboration with Prof Elinav and Prof Segal, The Weizmann Institute of Science).
  2. Reverse engineering insulin secretion in health and disease (in collaboration with leading obesity clinicians in hospitals across Sydney) - PhD project available in clinical study settings