Dr Dorit Samocha-Bonet
Conjoint Associate Professor

Dr Dorit Samocha-Bonet

Academic Record

2001 - 2006

PhD, Physiology and Pharmacology, Sackler School of Medicine, Tel-Aviv University, Israel.

1993 - 1996

MSc, Clinical Biochemistry, Sackler School of Medicine, Tel-Aviv University, Israel. With Honours.

1989 - 1992

BSc, Nutritional Sciences, Hebrew University, Faculty of Agricultural, Food and Environmental Quality Sciences, Israel. Cum Laude.

 

Other Qualifications

1993                                Dietitian (recognition by the Israeli Ministry of Health, Department of Medical Professions)

Medicine & Health
School of Clinical Medicine

Samocha-Bonet is Group leader, Clinical Insulin Resistance at the Healthy Ageing Theme at the Garvan Institute of Medical Research, and a Conjoint Senior Lecturer, School of Medical Sciences UNSW. Samocha-Bonet completed a BSc degree (Cum Laude) in Nutritional Sciences at the Hebrew University, Israel and joined the Nutrition & Dietetics Department at Tel Aviv Medical Centre as a clinical dietician where she worked for a decade (1993-2003). She completed MSc degree (with Honours) in Clinical Biochemistry (1996) and PhD in Physiology & Pharmacology (2006) at Tel Aviv University, Israel prior to relocating to Sydney. She joined the Garvan Institute of Medical Research in 2007 as a postdoctoral fellow. In 2013 she established the Clinical Insulin Resistance Group with a focus on exploring the metabolic factors underlying insulin resistance and insulin sensitivity in obesity and on developing approaches to promoting insulin sensitivity in obesity. She has been the Australian Diabetes Society (ADS) Skip Martin Early Career Fellow in 2011, and the recipient of the top ranked project grant from the Diabetes Australia Research Program in 2016.

Phone
+61292958309
Location
Garvan Institute of Medical Research 384 Victoria Street Darlinghurst 2010
  • Book Chapters | 2023
    Wark G; Samocha-Bonet D; Ghaly S; Danta M, 2023, 'The role of nutrition in inflammatory bowel disease: Disease associations, management of active disease and maintenance of remission', in Encyclopedia of Human Nutrition, Elsevier, pp. 669 - 697, http://dx.doi.org/10.1016/b978-0-12-821848-8.00104-9
  • Journal articles | 2022
    Koay YC; Coster ACF; Chen DL; Milner B; Batarseh A; O’Sullivan JF; Greenfield JR; Samocha-Bonet D, 2022, 'Metabolomics and Lipidomics Signatures of Insulin Resistance and Abdominal Fat Depots in People Living with Obesity', Metabolites, vol. 12, http://dx.doi.org/10.3390/metabo12121272
    Journal articles | 2021
    Bishay RH; Tonks KT; George J; Samocha-Bonet D; Meyerowitz-Katz G; Chisholm DJ; James DE; Greenfield JR, 2021, 'Plasma Bile Acids More Closely Align with Insulin Resistance, Visceral and Hepatic Adiposity Than Total Adiposity', Journal of Clinical Endocrinology and Metabolism, vol. 106, pp. E1131 - E1139, http://dx.doi.org/10.1210/clinem/dgaa940
    Journal articles | 2021
    Lambert K; Pappas D; Miglioretto C; Javadpour A; Reveley H; Frank L; Grimm MC; Samocha-Bonet D; Hold GL, 2021, 'Systematic review with meta-analysis: dietary intake in adults with inflammatory bowel disease', Alimentary Pharmacology and Therapeutics, vol. 54, pp. 742 - 754, http://dx.doi.org/10.1111/apt.16549
    Journal articles | 2021
    Samocha-Bonet D; Wu B; Ryugo DK, 2021, 'Diabetes mellitus and hearing loss: A review', Ageing Research Reviews, vol. 71, pp. 101423 - 101423, http://dx.doi.org/10.1016/j.arr.2021.101423
    Journal articles | 2021
    Snaith JR; Samocha-Bonet D; Evans J; Liu Z; Kowalski G; Bruce C; Holmes-Walker DJ; Greenfield JR, 2021, 'Insulin resistance in type 1 diabetes managed with metformin (INTIMET): Study protocol of a double-blind placebo-controlled, randomised trial', Diabetic Medicine, vol. 38, pp. e14564, http://dx.doi.org/10.1111/dme.14564
    Journal articles | 2021
    Wark G; Samocha-Bonet D; Ghaly S; Danta M, 2021, 'The role of diet in the pathogenesis and management of inflammatory bowel disease: A review', Nutrients, vol. 13, pp. 1 - 26, http://dx.doi.org/10.3390/nu13010135
    Journal articles | 2021
    Watt KI; Henstridge DC; Ziemann M; Sim CB; Montgomery MK; Samocha-Bonet D; Parker BL; Dodd GT; Bond ST; Salmi TM; Lee RS; Thomson RE; Hagg A; Davey JR; Qian H; Koopman R; El-Osta A; Greenfield JR; Watt MJ; Febbraio MA; Drew BG; Cox AG; Porrello ER; Harvey KF; Gregorevic P, 2021, 'Yap regulates skeletal muscle fatty acid oxidation and adiposity in metabolic disease', Nature Communications, vol. 12, pp. 2887, http://dx.doi.org/10.1038/s41467-021-23240-7
    Journal articles | 2021
    Williams AJ; Paramsothy R; Wu N; Ghaly S; Leach S; Paramsothy S; Corte C; O'Brien C; Burke C; Wark G; Samocha-Bonet D; Lambert K; Ahlenstiel G; Wasinger V; Dutt S; Pavli P; Grimm M; Lemberg D; Connor S; Leong R; Hold G, 2021, 'Australia IBD Microbiome (AIM) Study: Protocol for a multicentre longitudinal prospective cohort study', BMJ Open, vol. 11, pp. e042493, http://dx.doi.org/10.1136/bmjopen-2020-042493
    Journal articles | 2020
    Harari A; Coster ACF; Jenkins A; Xu A; Greenfield JR; Harats D; Shaish A; Samocha-Bonet D, 2020, 'Obesity and Insulin Resistance Are Inversely Associated with Serum and Adipose Tissue Carotenoid Concentrations in Adults', Journal of Nutrition, vol. 150, pp. 38 - 46, http://dx.doi.org/10.1093/jn/nxz184
    Journal articles | 2020
    Htet TD; Godneva A; Liu Z; Chalmers E; Kolobkov D; Snaith JR; Richens R; Toth K; Danta M; Hng TM; Elinav E; Segal E; Greenfield JR; Samocha-Bonet D, 2020, 'Rationale and design of a randomised controlled trial testing the effect of personalised diet in individuals with pre-diabetes or type 2 diabetes mellitus treated with metformin', BMJ Open, vol. 10, pp. e037859, http://dx.doi.org/10.1136/bmjopen-2020-037859
    Journal articles | 2020
    Montgomery MK; Bayliss J; Devereux C; Bezawork-Geleta A; Roberts D; Huang C; Schittenhelm RB; Ryan A; Townley SL; Selth LA; Biden TJ; Steinberg GR; Samocha-Bonet D; Meex RCR; Watt MJ, 2020, 'SMOC1 is a glucose-responsive hepatokine and therapeutic target for glycemic control', Science Translational Medicine, vol. 12, http://dx.doi.org/10.1126/SCITRANSLMED.AAZ8048
    Journal articles | 2020
    Snaith JR; Samocha-Bonet D; Holmes-Walker DJ; Greenfield JR, 2020, 'MON-LB113 Insulin Resistance in Type 1 Diabetes Managed With Metformin (INTIMET): Rationale and Study Design of a Randomised Placebo-Controlled Trial', Journal of the Endocrine Society, vol. 4, http://dx.doi.org/10.1210/jendso/bvaa046.2038
    Journal articles | 2020
    Wali JA; Koay YC; Chami J; Wood C; Corcilius L; Payne RJ; Rodionov RN; Birkenfeld AL; Samocha-Bonet D; Simpson SJ; O’Sullivan JF, 2020, 'Nutritional and metabolic regulation of the metabolite dimethylguanidino valeric acid: an early marker of cardiometabolic disease', American Journal of Physiology - Endocrinology and Metabolism, vol. 319, pp. E509 - E518, http://dx.doi.org/10.1152/ajpendo.00207.2020
    Journal articles | 2019
    Milder TY; Stocker SL; Samocha-Bonet D; Day RO; Greenfield JR, 2019, 'Sodium-glucose cotransporter 2 inhibitors for type 2 diabetes—cardiovascular and renal benefits in patients with chronic kidney disease', European Journal of Clinical Pharmacology, vol. 75, pp. 1481 - 1490, http://dx.doi.org/10.1007/s00228-019-02732-y
    Journal articles | 2019
    Milder TY; Stocker SL; Shaheed CA; McGrath-Cadell L; Samocha-Bonet D; Greenfield JR; Day RO, 2019, 'Combination Therapy with an SGLT2 Inhibitor as Initial Treatment for Type 2 Diabetes: A Systematic Review and Meta-Analysis', JOURNAL OF CLINICAL MEDICINE, vol. 8, http://dx.doi.org/10.3390/jcm8010045
    Journal articles | 2019
    Tang A; Coster ACF; Tonks KT; Heilbronn LK; Pocock N; Purtell L; Govendir M; Blythe J; Zhang J; Xu A; Chisholm DJ; Johnson NA; Greenfield JR; Samocha-Bonet D, 2019, 'Longitudinal changes in insulin resistance in normal weight, overweight and obese individuals', Journal of Clinical Medicine, vol. 8, http://dx.doi.org/10.3390/jcm8050623
    Journal articles | 2018
    Du YT; Piscitelli D; Ahmad S; Trahair LG; Greenfield JR; Samocha-Bonet D; Rayner CK; Horowitz M; Jones KL, 2018, 'Effects of glutamine on gastric emptying of lowand high-nutrient drinks in healthy young subjects—impact on glycaemia', Nutrients, vol. 10, http://dx.doi.org/10.3390/nu10060739
    Journal articles | 2018
    Elshorbagy AK; Samocha-Bonet D; Jernerén F; Turner C; Refsum H; Heilbronn LK, 2018, 'Food Overconsumption in Healthy Adults Triggers Early and Sustained Increases in Serum Branched-Chain Amino Acids and Changes in Cysteine Linked to Fat Gain', The Journal of nutrition, vol. 148, pp. 1073 - 1080, http://dx.doi.org/10.1093/jn/nxy062
    Journal articles | 2018
    Fazakerley DJ; Chaudhuri R; Yang P; Maghzal GJ; Thomas KC; Krycer JR; Humphrey SJ; Parker BL; Fisher-Wellman KH; Meoli CC; Hoffman NJ; Diskin C; Burchfield JG; Cowley MJ; Kaplan W; Modrusan Z; Kolumam G; Yang JYH; Chen DL; Samocha-Bonet D; Greenfield JR; Hoehn KL; Stocker R; James DE, 2018, 'Mitochondrial CoQ deficiency is a common driver of mitochondrial oxidants and insulin resistance', eLife, vol. 7, http://dx.doi.org/10.7554/eLife.32111
    Journal articles | 2018
    Ma C; Tonks KT; Center JR; Samocha-Bonet D; Greenfield JR, 2018, 'Complex interplay among adiposity, insulin resistance and bone health', Clinical Obesity, vol. 8, pp. 131 - 139, http://dx.doi.org/10.1111/cob.12240
    Journal articles | 2018
    Samocha-Bonet D; Debs S; Greenfield JR, 2018, 'Prevention and Treatment of Type 2 Diabetes: A Pathophysiological-Based Approach', Trends in Endocrinology and Metabolism, vol. 29, pp. 370 - 379, http://dx.doi.org/10.1016/j.tem.2018.03.014
    Journal articles | 2017
    Chen DLT; Brown R; Liess C; Poljak A; Xu A; Zhang J; Trenell M; Jenkins A; Chisholm D; Samocha-Bonet D; Macefield VG; Greenfield JR, 2017, 'Muscle sympathetic nerve activity is associated with liver insulin sensitivity in obese non-diabetic men', Frontiers in Physiology, vol. 8, http://dx.doi.org/10.3389/fphys.2017.00101
    Journal articles | 2017
    Mackie GM; Samocha-Bonet D; Tam CS, 2017, 'Does weight cycling promote obesity and metabolic risk factors?', Obesity Research and Clinical Practice, vol. 11, pp. 131 - 139, http://dx.doi.org/10.1016/j.orcp.2016.10.284
    Journal articles | 2017
    Tam CS; Chaudhuri R; Hutchison AT; Samocha-Bonet D; Heilbronn LK, 2017, 'Skeletal muscle extracellular matrix remodeling after short-term overfeeding in healthy humans', Metabolism: Clinical and Experimental, vol. 67, pp. 26 - 30, http://dx.doi.org/10.1016/j.metabol.2016.10.009
    Journal articles | 2017
    Tonks KT; White CP; Center JR; Samocha-Bonet D; Greenfield JR, 2017, 'Bone turnover is suppressed in insulin resistance, independent of adiposity', Journal of Clinical Endocrinology and Metabolism, vol. 102, pp. 1112 - 1121, http://dx.doi.org/10.1210/jc.2016-3282
    Journal articles | 2016
    Elshorbagy AK; Jernerén F; Samocha-Bonet D; Refsum H; Heilbronn LK, 2016, 'Serum S-adenosylmethionine, but not methionine, increases in response to overfeeding in humans', Nutrition and Diabetes, vol. 6, http://dx.doi.org/10.1038/nutd.2015.44
    Journal articles | 2016
    He J; Chen DL; Samocha-Bonet D; Gillinder KR; Barclay JL; Magor GW; Perkins AC; Greenfield JR; Yang G; Whitehead JP, 2016, 'Fibroblast growth factor-1 (FGF-1) promotes adipogenesis by downregulation of carboxypeptidase A4 (CPA4)–a negative regulator of adipogenesis implicated in the modulation of local and systemic insulin sensitivity', Growth Factors, vol. 34, pp. 210 - 216, http://dx.doi.org/10.1080/08977194.2017.1285764
    Journal articles | 2016
    Lee-Young RS; Hoffman NJ; Murphy KT; Henstridge DC; Samocha-Bonet D; Siebel AL; Iliades P; Zivanovic B; Hong YH; Colgan TD; Kraakman MJ; Bruce CR; Gregorevic P; McConell GK; Lynch GS; Drummond GR; Kingwell BA; Greenfield JR; Febbraio MA, 2016, 'Glucose-6-phosphate dehydrogenase contributes to the regulation of glucose uptake in skeletal muscle', Molecular Metabolism, vol. 5, pp. 1083 - 1091, http://dx.doi.org/10.1016/j.molmet.2016.09.002
    Journal articles | 2016
    Radhakutty A; Mangelsdorf BL; Drake SM; Samocha-Bonet D; Heilbronn LK; Smith MD; Thompson CH; Burt MG, 2016, 'Effects of prednisolone on energy and fat metabolism in patients with rheumatoid arthritis: tissue-specific insulin resistance with commonly used prednisolone doses', Clinical Endocrinology, vol. 85, pp. 741 - 747, http://dx.doi.org/10.1111/cen.13138
    Journal articles | 2016
    Radhakutty A; Mangelsdorf BL; Drake SM; Samocha-Bonet D; Jenkins AB; Heilbronn LK; Smith MD; Thompson CH; Burt MG, 2016, 'Effect of acute and chronic glucocorticoid therapy on insulin sensitivity and postprandial vascular function', Clinical Endocrinology, vol. 84, pp. 501 - 508, http://dx.doi.org/10.1111/cen.12966
    Journal articles | 2016
    Tonks KT; Coster AC; Christopher MJ; Chaudhuri R; Xu A; Gagnon-Bartsch J; Chisholm DJ; James DE; Meikle PJ; Greenfield JR; Samocha-Bonet D, 2016, 'Skeletal muscle and plasma lipidomic signatures of insulin resistance and overweight/obesity in humans', Obesity, vol. 24, pp. 908 - 916, http://dx.doi.org/10.1002/oby.21448
    Journal articles | 2016
    Williams RS; Kozan P; Samocha-Bonet D, 2016, 'The role of dietary acid load and mild metabolic acidosis in insulin resistance in humans', Biochimie, vol. 124, pp. 171 - 177, http://dx.doi.org/10.1016/j.biochi.2015.09.012
    Journal articles | 2015
    Chaudhuri R; Khoo PS; Tonks K; Junutula JR; Kolumam G; Modrusan Z; Samocha-Bonet D; Meoli CC; Hocking S; Fazakerley DJ; Stöckli J; Hoehn KL; Greenfield JR; Yang JYH; James DE, 2015, 'Cross-species gene expression analysis identifies a novel set of genes implicated in human insulin sensitivity', npj Systems Biology and Applications, vol. 1, http://dx.doi.org/10.1038/npjsba.2015.10
    Journal articles | 2015
    Chen DL; Liess C; Poljak A; Xu A; Zhang J; Thoma C; Trenell M; Milner B; Jenkins AB; Chisholm DJ; Samocha-Bonet D; Greenfield JR, 2015, 'Phenotypic characterization of insulin-resistant and insulin-sensitive obesity', Journal of Clinical Endocrinology and Metabolism, vol. 100, pp. 4082 - 4091, http://dx.doi.org/10.1210/jc.2015-2712
    Journal articles | 2015
    Samocha-Bonet D; Chisholm DJ; Holst JJ; Greenfield JR, 2015, 'L-glutamine and whole protein restore first-phase insulin response and increase glucagon-like peptide-1 in type 2 diabetes patients', Nutrients, vol. 7, pp. 2101 - 2108, http://dx.doi.org/10.3390/nu7042101
    Journal articles | 2015
    Williams RS; Heilbronn LK; Chen DL; Coster A; Greenfield JR; Samocha-Bonet D, 2015, 'Dietary acid load, metabolic acidosis and insulin resistance - Lessons from cross-sectional and overfeeding studies in humans', Clinical Nutrition, vol. 35, pp. 1084 - 1090, http://dx.doi.org/10.1016/j.clnu.2015.08.002
    Journal articles | 2014
    Milner KL; Jenkins AB; Trenell M; Tid-Ang J; Samocha-Bonet D; Weltman M; Xu A; George J; Chisholm DJ, 2014, 'Eradicating hepatitis C virus ameliorates insulin resistance without change in adipose depots', Journal of Viral Hepatitis, vol. 21, pp. 325 - 332, http://dx.doi.org/10.1111/jvh.12143
    Journal articles | 2014
    Samocha-Bonet D; Chisholm DJ; Gribble FM; Coster ACF; Carpenter KH; Jones GRD; Holst JJ; Greenfield JR, 2014, 'Glycemic effects and safety of L-glutamine supplementation with or without sitagliptin in type 2 diabetes patients-a randomized study', PLoS ONE, vol. 9, http://dx.doi.org/10.1371/journal.pone.0113366
    Journal articles | 2014
    Samocha-Bonet D; Dixit VD; Kahn CR; Leibel RL; Lin X; Nieuwdorp M; Pietiläinen KH; Rabasa-Lhoret R; Roden M; Scherer PE; Klein S; Ravussin E, 2014, 'Metabolically healthy and unhealthy obese - The 2013 stock conference report', Obesity Reviews, vol. 15, pp. 697 - 708, http://dx.doi.org/10.1111/obr.12199
    Journal articles | 2014
    Samocha-Bonet D; Tam CS; Campbell LV; Heilbronn LK, 2014, 'Raised circulating fetuin-a after 28-day overfeeding in healthy humans', Diabetes Care, vol. 37, http://dx.doi.org/10.2337/dc13-1728
    Journal articles | 2014
    Sato K; Samocha-Bonet D; Handelsman DJ; Fujita S; Wittert GA; Heilbronn LK, 2014, 'Serum sex steroids and steroidogenesis-related enzyme expression in skeletal muscle during experimental weight gain in men', Diabetes and Metabolism, vol. 40, pp. 439 - 444, http://dx.doi.org/10.1016/j.diabet.2014.03.006
    Journal articles | 2014
    Wu LE; Samocha-Bonet D; Whitworth PT; Fazakerley DJ; Turner N; Biden TJ; James DE; Cantley J, 2014, 'Identification of fatty acid binding protein 4 as an adipokine that regulates insulin secretion during obesity', Molecular Metabolism, vol. 3, pp. 465 - 473, http://dx.doi.org/10.1016/j.molmet.2014.02.005
    Journal articles | 2013
    Chang J; Wu T; Greenfield JR; Samocha-Bonet D; Horowitz M; Rayner CK, 2013, 'Effects of Intraduodenal Glutamine on Incretin Hormone and Insulin Release, the Glycemic Response to an Intraduodenal Glucose Infusion, and Antropyloroduodenal Motility in Health and Type 2 Diabetes', Diabetes Care, vol. 36, pp. 2262 - 2265, http://dx.doi.org/10.2337/dc12-1663
    Journal articles | 2013
    Heilbronn LK; Campbell LV; Xu A; Samocha-Bonet D, 2013, 'Metabolically Protective Cytokines Adiponectin and Fibroblast Growth Factor-21 Are Increased by Acute Overfeeding in Healthy Humans', PLoS ONE, vol. 8, http://dx.doi.org/10.1371/journal.pone.0078864
    Journal articles | 2013
    Heilbronn LK; Coster ACF; Campbell LV; Greenfield JR; Lange K; Christopher MJ; Meikle PJ; Samocha-Bonet D, 2013, 'The effect of short-term overfeeding on serum lipids in healthy humans', Obesity, vol. 21, http://dx.doi.org/10.1002/oby.20508
    Journal articles | 2013
    Hocking S; Samocha-Bonet D; Milner KL; Greenfield JR; Chisholm DJ, 2013, 'Adiposity and insulin resistance in humans: The role of the different tissue and cellular lipid depots', Endocrine Reviews, vol. 34, pp. 463 - 500, http://dx.doi.org/10.1210/er.2012-1041
    Journal articles | 2013
    Jenkins AB; Batterham M; Samocha-Bonet D; Tonks K; Greenfield JR; Campbell LV, 2013, 'Segregation of a Latent High Adiposity Phenotype in Families with a History of Type 2 Diabetes Mellitus Implicates Rare Obesity-Susceptibility Genetic Variants with Large Effects in Diabetes-Related Obesity', PLoS ONE, vol. 8, http://dx.doi.org/10.1371/journal.pone.0070435
    Journal articles | 2013
    Tonks KT; Ng Y; Miller S; Coster ACF; Samocha-Bonet D; Iseli TJ; Xu A; Patrick E; Yang JYH; Junutula JR; Modrusan Z; Kolumam G; Stöckli J; Chisholm DJ; James DE; Greenfield JR, 2013, 'Impaired Akt phosphorylation in insulin-resistant human muscle is accompanied by selective and heterogeneous downstream defects', Diabetologia, vol. 56, pp. 875 - 885, http://dx.doi.org/10.1007/s00125-012-2811-y
    Journal articles | 2012
    Gregersen S; Samocha-Bonet D; Heilbronn LK; Campbell LV, 2012, 'Inflammatory and oxidative stress responses to high-carbohydrate and high-fat meals in healthy humans', J Nutr Metab, vol. 2012, pp. 238056, http://dx.doi.org/10.1155/2012/238056
    Journal articles | 2012
    Samocha-Bonet D; Campbell LV; Mori TA; Croft KD; Greenfield JR; Turner N; Heilbronn LK, 2012, 'Overfeeding reduces insulin sensitivity and increases oxidative stress, without altering markers of mitochondrial content and function in humans', PLoS One, vol. 7, pp. e36320, http://dx.doi.org/10.1371/journal.pone.0036320
    Journal articles | 2012
    Samocha-Bonet D; Chisholm DJ; Tonks K; Campbell LV; Greenfield JR, 2012, 'Insulin-sensitive obesity in humans - a 'favorable fat' phenotype?', Trends Endocrinol Metab, vol. 23, pp. 116 - 124, http://dx.doi.org/10.1016/j.tem.2011.12.005
    Journal articles | 2012
    Viardot A; Heilbronn LK; Samocha-Bonet D; Mackay F; Campbell LV; Samaras K, 2012, 'Obesity is associated with activated and insulin resistant immune cells', Diabetes/metabolism research and reviews, vol. 28, pp. 447 - 454, http://dx.doi.org/10.1002/dmrr.2302
    Journal articles | 2011
    Samocha-Bonet D; Wong O; Synnott EL; Piyaratna N; Douglas A; Gribble FM; Holst JJ; Chisholm DJ; Greenfield JR, 2011, 'Glutamine reduces postprandial glycemia and augments the glucagon-like peptide-1 response in type 2 diabetes patients', J Nutr, vol. 141, pp. 1233 - 1238, http://dx.doi.org/10.3945/jn.111.139824
    Journal articles | 2010
    Samocha-Bonet D; Campbell LV; Viardot A; Freund J; Tam CS; Greenfield JR; Heilbronn LK, 2010, 'A family history of type 2 diabetes increases risk factors associated with overfeeding', Diabetologia, vol. 53, pp. 1700 - 1708, http://dx.doi.org/10.1007/s00125-010-1768-y
    Journal articles | 2010
    Samocha-Bonet D; Heilbronn LK; Lichtenberg D; Campbell LV, 2010, 'Does skeletal muscle oxidative stress initiate insulin resistance in genetically predisposed individuals?', Trends Endocrinol Metab, vol. 21 (2), pp. 83 - 87, http://dx.doi.org/10.1016/j.tem.2009.09.008
    Journal articles | 2010
    Tam CS; Viardot A; Clement K; Tordjman J; Tonks K; Greenfield JR; Campbell LV; Samocha-Bonet D; Heilbronn LK, 2010, 'Short-term overfeeding may induce peripheral insulin resistance without altering subcutaneous adipose tissue macrophages in humans', Diabetes, vol. 59, pp. 2164 - 2170, http://dx.doi.org/10.2337/db10-0162
    Journal articles | 2008
    Samocha-Bonet D; Justo D; Rogowski O; Saar N; Abu-Abeid S; Shenkerman G; Shapira I; Berliner S; Tomer A, 2008, 'Platelet counts and platelet activation markers in obese subjects', Mediators of Inflammation, vol. 2008, http://dx.doi.org/10.1155/2008/834153
    Journal articles | 2005
    Assayag EB; Bornstein N; Shapira I; Mardi T; Goldin Y; Tolshinski T; Vered Y; Zakuth V; Burke M; Berliner S; Bonet DS, 2005, 'Inflammation-sensitive proteins and erythrocyte aggregation in atherothrombosis', Int J Cardiol, vol. 98, pp. 271 - 276, http://dx.doi.org/10.1016/j.ijcard.2003.12.013
    Journal articles | 2004
    Samocha-Bonet D; Ben-Ami R; Shapira I; Shenkerman G; Abu-Abeid S; Stern N; Mardi T; Tulchinski T; Deutsch V; Yedgar S; Barshtein G; Berliner S, 2004, 'Flow-resistant red blood cell aggregation in morbid obesity', International Journal of Obesity, vol. 28, pp. 1528 - 1534, http://dx.doi.org/10.1038/sj.ijo.0802791
    Journal articles | 2003
    Samocha-Bonet D; Lichtenberg D; Tomer A; Deutsch V; Mardi T; Goldin Y; Abu-Abeid S; Shenkerman G; Patshomik H; Shapira I; Berliner S, 2003, 'Enhanced erythrocyte adhesiveness/aggregation in obesity corresponds to low-grade inflammation', Obesity Research, vol. 11, pp. 403 - 407, http://dx.doi.org/10.1038/oby.2003.54

Research at the Clinical Insulin Resistance Group at the Garvan is focused on uncovering the molecular pathways involved in the transition from health to insulin resistance and metabolic disease related to overweight and obesity in humans. In our clinical studies, we use gold-standard protocols to deeply phenotype individuals at risk of type 2 diabetes. Using gold-standard tools to characterise whole-body glucose regulation, abdominal fat distribution and liver fat, we find a wide range of phenotypic variation in obesity and prediabetes.

Current projects:

  1. A randomised clinical trial (https://clinicaltrials.gov/NCT03558867) to test the efficacy of an algorithm-based (personalised) diet in combination with metformin on glycaemia in individuals with prediabetes and type 2 diabetes (in collaboration with Prof Elinav and Prof Segal, The Weizmann Institute of Science).
  2. Reverse engineering insulin secretion in health and disease (in collaboration with leading obesity clinicians in hospitals across Sydney) - PhD project available in clinical study settings